Oxford Medical Case Reports最新文献_第3页

Semaglutide-associated drug-induced liver injury: a case report and review of the literature. 西马格鲁肽相关药物性肝损伤1例报告及文献复习。

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Oxford Medical Case Reports Pub Date : 2025-09-28 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf177

Ian Kempster, Darren Fernandes, Mohammed S Saeed, Caroline Sharratt, Sara Benfield

{"title":"Semaglutide-associated drug-induced liver injury: a case report and review of the literature.","authors":"Ian Kempster, Darren Fernandes, Mohammed S Saeed, Caroline Sharratt, Sara Benfield","doi":"10.1093/omcr/omaf177","DOIUrl":"10.1093/omcr/omaf177","url":null,"abstract":"Semaglutide is a glucagon-like peptide-1 receptor agonist (GLP-1RA) used to manage type 2 diabetes and, since 2021, for weight loss in individuals with obesity or weight-related comorbidities. It works by enhancing insulin secretion, delaying gastric emptying and reducing appetite. Common side effects include hypoglycaemia, gastrointestinal disturbances, nausea, weight loss and cholelithiasis. While some studies have noted an association with acute kidney injury, reports of liver injury are rare. We present a rare case of drug-induced liver injury in a middle-aged female, associated with transient liver failure after semaglutide use. She presented one month after starting the medication with rapidly worsening liver function tests. Investigations, including a non-invasive liver screen, viral studies, ultrasound and CT imaging, revealed no clear cause. A liver biopsy supported the diagnosis of drug-induced liver injury. The patient improved with supportive treatment and withdrawal of semaglutide. This case underscores the importance of clinician awareness given its increasing, and often unregulated, use for weight loss.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 9","pages":"omaf177"},"PeriodicalIF":0.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145193507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lerich syndrome revealed by renal failure: a case report. 肾衰表现为利希综合征1例。

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Oxford Medical Case Reports Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf159

Sara Anibar, Mohammed Elalami, Mounir Salek, Mohammed Bouchoual, Soukaina Wakrim, Marouane Jabrane, Mohamed Arrayhani

引用次数: 0

A rare case of Langerhans cell histiocytosis with unexplained endocrine dysfunction and extensive skeletal involvement in a Pediatric patient. 一例罕见的朗格汉斯细胞组织细胞增多症伴不明原因的内分泌功能障碍和广泛的骨骼受累。

IF 0.4

Oxford Medical Case Reports Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf155

Carlos Díaz Q, Marcos Orellana, Rolando Chajon, José Valenzuela, Pedro Chajon

引用次数: 0

Local mushroom poisoning: a case report study. 当地蘑菇中毒1例报告研究。

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Oxford Medical Case Reports Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf121

Mahsa Rizebandi, Faezeh Sehtpour, Farhad Mohammadi

{"title":"Local mushroom poisoning: a case report study.","authors":"Mahsa Rizebandi, Faezeh Sehtpour, Farhad Mohammadi","doi":"10.1093/omcr/omaf121","DOIUrl":"10.1093/omcr/omaf121","url":null,"abstract":"Introduction: Poisoning by poisonous local mushrooms that resemble edible mushrooms is a serious health hazard with severe consequences. Wild and unidentified mushrooms are the main cause of these poisonings. Successful treatment requires prompt medical intervention, and if delayed, a liver transplant may be necessary.Case report: A 26-year-old woman with postpartum cardiomyopathy was admitted to Razi Hospital with abdominal pain, dizziness, nausea, and vomiting. She was diagnosed with poisoning from local mountain mushrooms and transferred to the ICU due to low blood pressure, elevated enzymes, and tachycardia. Echocardiography showed severe cardiac dysfunction (EF = 25%), and she developed severe tachycardia, decreased consciousness, and metabolic-respiratory acidosis. After dialysis and treatment with NAC infusion for 7 days, her consciousness improved, she was extubated, and EF increased to 40%.Conclusion: The patient gradually improved after 6 days in ICU, with pancreatitis resolving and bilateral lower extremity paresthesia diagnosed and subsequently improved.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 9","pages":"omaf121"},"PeriodicalIF":0.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivalvular infective endocarditis due to streptococcus pluranimalium in a young patient with bicuspid aortic valve. 多动物链球菌所致多瓣感染性心内膜炎1例年轻二尖瓣主动脉瓣患者。

IF 0.4

Oxford Medical Case Reports Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf156

José Emmanuel Zúñiga-Espinosa, Ana Lilia Peralta-Amaro, Melina Ivone Tejada-Ruíz, José Alfredo Delgado-Cruz, Mariel Ivonne García-Santiago

引用次数: 0

New-onset seizure In Peripartum period: a case of Sjögren's syndrome with renal artery stenosis. 围产期新发癫痫：Sjögren综合征合并肾动脉狭窄1例。

IF 0.4

Oxford Medical Case Reports Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf199

Rahul Parajuli, Santosh Basyal, Agnimshwor Dahal, Rebicca Pradhan

引用次数: 0

Acute liver injury as a manifestation of granulomatous hepatitis: diagnostic challenges. 急性肝损伤作为肉芽肿性肝炎的表现：诊断挑战。

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Oxford Medical Case Reports Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf160

Melissa N Martinez-Marquez, Sandra M Feria-Agudelo, Lumi G Alfonso-Zapata, German Barrientos-Cabrera, Jesús Ruiz-Manríquez, Froylan D Martínez-Sánchez

{"title":"Acute liver injury as a manifestation of granulomatous hepatitis: diagnostic challenges.","authors":"Melissa N Martinez-Marquez, Sandra M Feria-Agudelo, Lumi G Alfonso-Zapata, German Barrientos-Cabrera, Jesús Ruiz-Manríquez, Froylan D Martínez-Sánchez","doi":"10.1093/omcr/omaf160","DOIUrl":"10.1093/omcr/omaf160","url":null,"abstract":"Granulomatous hepatitis is a rare clinical entity characterized by granuloma formation in the liver, with a diverse etiology that includes infectious, autoimmune, and malignant causes. This case report details a 35-year-old male presenting with jaundice, abdominal pain, and malaise. Laboratory findings showed features of acute liver injury, with elevated liver enzymes and bilirubin, while imaging studies revealed hepatomegaly and lymphadenopathy. A liver biopsy confirmed non-caseating granulomas, with negative results for infectious and autoimmune etiologies. Further investigations, including a bone marrow biopsy, identified Hodgkin's lymphoma, establishing the diagnosis of granulomatous hepatitis as a paraneoplastic manifestation. The patient was referred for oncological treatment, underscoring the critical role of liver biopsy and histopathological evaluation in diagnosing granulomatous hepatitis of unclear origin. This case highlights the diagnostic complexities and the need for a multidisciplinary approach in identifying systemic malignancies presenting with hepatic manifestations.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 9","pages":"omaf160"},"PeriodicalIF":0.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hidden clue behind angioedema in an elderly patient. 老年患者血管性水肿背后的隐藏线索。

IF 0.4

Oxford Medical Case Reports Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf157

Okan Cetin, Ilkim Deniz Toprak, Gamze Kemec, Simge Erdem, Gulcin Yegen, Semra Demir

引用次数: 0

A rare case of McCune-Albright syndrome in a young male with hyperthyroidism and hypertrophic scars. 一例罕见的麦丘内-奥尔布赖特综合征的年轻男性甲状腺机能亢进和增生性疤痕。

IF 0.4

Oxford Medical Case Reports Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf158

Bayar A Qasim, Rende S A Kochary, Halder J Abozait, Omed O Ismail

引用次数: 0

Infantile systemic Hyalinosis in a 6-month-old male: identification of homozygous ANTXR2 gene mutation. 6个月大男性婴儿系统性透明质病：纯合子ANTXR2基因突变的鉴定

IF 0.4

Oxford Medical Case Reports Pub Date : 2025-09-15 eCollection Date: 2025-09-01 DOI: 10.1093/omcr/omaf091

Fereshteh Moshfegh, Zahra Hosseinzade, Mohammad Javanbakht, Asma Javid, Mahsa Mozaffari

{"title":"Infantile systemic Hyalinosis in a 6-month-old male: identification of homozygous ANTXR2 gene mutation.","authors":"Fereshteh Moshfegh, Zahra Hosseinzade, Mohammad Javanbakht, Asma Javid, Mahsa Mozaffari","doi":"10.1093/omcr/omaf091","DOIUrl":"10.1093/omcr/omaf091","url":null,"abstract":"This case report presents a 6-month-old male infant with a diagnosis of infantile systemic hyalinosis (ISH) and describes the diagnostic difficulties and findings of clinical examinations, laboratory analyses, and imaging studies. A 6-month-old male infant was admitted with abdominal distension, persistent diarrhea, and joint tenderness. His history included profuse watery diarrhea and a hospitalization for hypoalbuminemia. Upon arrival, he presented with multiple episodes of non-bloody diarrhea, oxygen desaturation, and signs of failure to thrive. Physical examination revealed joint swelling, spasticity, failure to thrive, short stature and developmental delays. Imaging studies including abdominal and pelvic ultrasound showed free fluid, intestinal distension, and renal microlithiasis. Imaging results included a chest X-ray showing mild interstitial markings and a brain MRI showing dilatation of subarachnoid space. Laboratory studies demonstrated an elevated white blood cell count (13 300 cells/mm3), high levels of ammonia, and relatively low hemoglobin. Ultimately, the diagnosis of ISH was confirmed by a homozygous ANTXR2 gene mutation. This case accentuates the need for an integrated approach to the diagnosis of nonspecific infant symptoms. Diagnosis should be made early and accurately with a high index of suspicion; it forms the cornerstone for any treatment or prevention of complications. Furthermore, the early recognition of ISH is important in effective management and family counseling with the aid of genetic analysis. The findings add to the knowledge about ISH and its clinical implications, pointing to the need for continued research into rare genetic disorders.","PeriodicalId":45318,"journal":{"name":"Oxford Medical Case Reports","volume":"2025 9","pages":"omaf091"},"PeriodicalIF":0.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0