Neil Limaye, Hannah Masraf, Henry Conchie, Adrian Lim
{"title":"The Diagnostic Utility of Ultrasound in Myxofibrosarcoma: Insights From a Multimodal Imaging Case Study.","authors":"Neil Limaye, Hannah Masraf, Henry Conchie, Adrian Lim","doi":"10.1055/a-2826-3276","DOIUrl":"https://doi.org/10.1055/a-2826-3276","url":null,"abstract":"","PeriodicalId":44852,"journal":{"name":"Ultrasound International Open","volume":"12 ","pages":"a28263276"},"PeriodicalIF":1.6,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contrast-enhanced Perfusion Measurements in Patients with Active Crohn's Disease Using Sonazoid.","authors":"Kim Nylund, Fredrik Sævik, Odd Helge Gilja","doi":"10.1055/a-2830-9879","DOIUrl":"https://doi.org/10.1055/a-2830-9879","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the feasibility of dynamic contrast-enhanced ultrasound with Sonazoid, its correlation with disease activity, its ability to differentiate between remission/mild activity and moderate/severe activity, and if a region of interest including the mucosa and submucosa was different compared to one encompassing the entire wall.</p><p><strong>Materials and methods: </strong>We prospectively studied 48 patients with Crohn's disease who underwent colonoscopy and dynamic contrast-enhanced ultrasound with Sonazoid from 2015 to 2019. We compared the local simple endoscopic score for Crohn's disease in the most affected area with parameters from Vuebox, including peak enhancement, wash-in and wash-out area under the curves, wash-in and wash-out rates, and wash-in perfusion index. Region of interest-1 (ROI-1) included all wall layers, and region of interest-2 (ROI-2) included the mucosa and submucosa. Linear data and normalised data were used. Technical failure or a quality of fit value of<80% was considered a failed examination.</p><p><strong>Results: </strong>The feasibility of the dynamic contrast-enhanced ultrasound examination was 73%. No significant findings were noted in the linear data ( <i>p</i> >0.05). In the normalised data in both ROI-1 and ROI-2, the local simple endoscopic score for Crohn's disease correlated significantly with peak enhancement ( <i>r</i> =0.38 and <i>r</i> =0.35), wash-in rate ( <i>r</i> =0.34 and <i>r</i> =0.34), and wash-in perfusion index ( <i>r</i> =0.40 and <i>r</i> =0.37) and with wash-in area under the curve ( <i>r</i> =0.36) in ROI-2. In patients with moderate/severe disease peak enhancement, wash-in area under the curve, wash-out area under the curve, wash-in rate, and wash-in perfusion index were significantly higher in both region of interests ( <i>p</i> <0.05). All parameters were significantly different in ROI-1 and ROI-2 ( <i>p</i> <0.05).</p><p><strong>Conclusions: </strong>Dynamic contrast-enhanced ultrasound parameters can differentiate between remission/mild and moderate/severe activity in Crohn's disease, but the method has relatively low feasibility.</p>","PeriodicalId":44852,"journal":{"name":"Ultrasound International Open","volume":"12 ","pages":"a28309879"},"PeriodicalIF":1.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13062680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiuyun Lu, Jianqing Ye, Xiuwu Pan, Shaojun Chen, Liang Zhang, Ying Wang, Juan Cheng, Jiaying Cao, Li Wei, Xingang Cui, Yi Dong
{"title":"Analysis of correlation between dynamic contrast-enhanced ultrasound and angiogenesis activity of renal cell carcinoma.","authors":"Xiuyun Lu, Jianqing Ye, Xiuwu Pan, Shaojun Chen, Liang Zhang, Ying Wang, Juan Cheng, Jiaying Cao, Li Wei, Xingang Cui, Yi Dong","doi":"10.1055/a-2513-1054","DOIUrl":"10.1055/a-2513-1054","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the potential correlation of dynamic contrast-enhanced ultrasound (DCE-US) with angiogenesis activity of renal cell carcinoma (RCC).</p><p><strong>Materials and methods: </strong>Patients with surgery resection and histopathologically proven RCC lesions were included. B-mode ultrasound (BMUS) and contrast-enhanced ultrasound (CEUS) were performed one week before surgery. SonoVue was injected as the contrast agent. VueBox (Bracco, Italy) was used for the quantitative analysis. According to the histopathological and immunohistochemical results, patients were classified into two groups: active angiogenesis and inactive angiogenesis. Time intensity curves (TICs) and quantitative parameters were compared between two groups.</p><p><strong>Results: </strong>From July 2023 to November 2023, a total of 50 patients (13 females and 37 males, mean age 61.1±11.1 years) were included. The mean size of the lesions was 39.4±2.7 mm. Patients were classified into the active angiogenesis group (n=30) and the inactive angiogenesis group (n=20). On BMUS, 68.0% (34/50) of RCCs were visualized as hypoechoic lesions with ill-defined borders and irregular shapes (P>0.05). During cortical phase of CEUS, 72.6% (23/30) of RCCs with active angiogenesis were visualized with hyperenhancement (P=0.027). Only 30.0% (9/30) of RCCs with active angiogenesis showed hypo-enhancement in the parenchymal phase (P>0.05). Compared to the inactive angiogenesis group, TICs of the active angiogenesis group revealed faster and greater enhancement in the cortical phase, slower decline during the parenchymal phase, and an increased area under the curve. Among quantitative parameters, the active angiogenesis group showed the higher ratio of wash-in rate and wash-in perfusion index (P<0.05).</p><p><strong>Conclusion: </strong>DCE-US analysis has potential value in predicting angiogenesis activity in RCC lesions.</p>","PeriodicalId":44852,"journal":{"name":"Ultrasound International Open","volume":"11 ","pages":"a25131054"},"PeriodicalIF":1.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasonographic Diagnosis of Odontogenic Cutaneous Fistula: A Case Report Demonstrating the Value of Multimodal Imaging Diagnostics.","authors":"Chengcheng Yu, Linlin Ruan, Wei Zhang, Hao Wang","doi":"10.1055/a-2618-1777","DOIUrl":"https://doi.org/10.1055/a-2618-1777","url":null,"abstract":"","PeriodicalId":44852,"journal":{"name":"Ultrasound International Open","volume":"11 ","pages":"a26181777"},"PeriodicalIF":1.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144561462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yan Zhang, Lu Liang, Huachong Ma, Jiagang Han, Xiuzhang Lv, Huiyu Ge
{"title":"Evaluating Extended Field of View Imaging for Measuring Rectal Tumor Lowest Boundary to Anal Verge Distance via Transrectal Biplane Ultrasound.","authors":"Yan Zhang, Lu Liang, Huachong Ma, Jiagang Han, Xiuzhang Lv, Huiyu Ge","doi":"10.1055/a-2569-6939","DOIUrl":"10.1055/a-2569-6939","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to measure the precise distance from the lowest boundary of a rectal tumor to the anal verge (DTAV) in patients with rectal cancer.</p><p><strong>Materials and methods: </strong>A retrospective analysis was performed on clinical data from 70 rectal cancer patients. DTAV measurements were collected using transrectal biplane ultrasound, MRI, and colonoscopy.</p><p><strong>Results: </strong>The difference in DTAV measurements between the mean DTAV value obtained by ultrasound (US <sub>mean</sub> ) and colonoscopy exhibited a difference of 0.22 cm. In contrast, the difference between US <sub>mean</sub> and MRI was 0.48 cm, while the difference between MRI and colonoscopy was -0.26 cm. The ICC for DTAV measurements demonstrated excellent agreement, with values of 0.948 between US <sub>mean</sub> and MRI, 0.942 between US <sub>mean</sub> and colonoscopy, and 0.943 between MRI and colonoscopy. The minimum DTAV value obtained by ultrasound (US <sub>min</sub> ) was 5.05 cm, the middle DTAV value obtained by ultrasound (US <sub>mid</sub> ) was 5.10 cm, and the maximum DTAV value obtained by ultrasound (US <sub>max</sub> ) was 5.30 cm. Notably, the median values of the differences in DTAV measurements between US <sub>max</sub> and US <sub>min</sub> , US <sub>max</sub> and US <sub>mid</sub> , as well as US <sub>mid</sub> and US <sub>min</sub> , were 0.2 cm, 0.1 cm, and 0.1 cm, respectively. Furthermore, the consistency of DTAV measurements between US <sub>min</sub> and US <sub>mid</sub> , US <sub>max</sub> and US <sub>mid</sub> , as well as US <sub>min</sub> and US <sub>max</sub> was excellent, with all ICC values reaching 0.999. Additionally, the radiologist's reassessment of MRI DTAV data showed excellent consistency with the original results, with an ICC value of 0.985.</p><p><strong>Conclusion: </strong>Transrectal biplane ultrasound utilizing EFOV imaging technology exhibited both accuracy and reproducibility for measuring DTAV. This approach provided a highly efficient and practical clinical tool for DTAV measurement.</p>","PeriodicalId":44852,"journal":{"name":"Ultrasound International Open","volume":"11 ","pages":"a25696939"},"PeriodicalIF":1.3,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oliver Graupner, Caroline Rath, Linda Lecker, Jochen Ritgen, Bernhard Haller, Christian Enzensberger
{"title":"Fetomaternal Doppler sonography for the prediction of perinatal outcome in term pregnancies complicated by gestational diabetes mellitus: does it have potential?","authors":"Oliver Graupner, Caroline Rath, Linda Lecker, Jochen Ritgen, Bernhard Haller, Christian Enzensberger","doi":"10.1055/a-2554-0806","DOIUrl":"https://doi.org/10.1055/a-2554-0806","url":null,"abstract":"<p><strong>Purpose: </strong>Little is known about the benefit and interpretation of fetomaternal Doppler sonography in GDM for the prediction of an adverse perinatal outcome (APO). The aim of this study was to examine the performance of fetomaternal Doppler for APO prediction in pregnancies with GDM at term.</p><p><strong>Materials and methods: </strong>This is a retrospective cohort study of singleton, non-anomalous fetuses of women with GDM, who primarily had a vaginal delivery attempt. Study inclusion also required no other major fetomaternal abnormalities that make placental dysfunction likely. Data on fetomaternal Doppler sonography including umbilical artery pulsatility index (PI), middle cerebral artery (MCA) PI, cerebroplacental ratio (CPR), mean uterine artery PI, cerebro-placental-uterine ratio (CPUR) was collected from 37+0 weeks on. Multivariate logistic regression analyses were performed using maternal characteristics, neonatal characteristics, and Doppler ultrasound parameters as independent variables with CAPO as a binary outcome.</p><p><strong>Results: </strong>A total of n=88 cases were included. Nulliparity (p=0.032) and CPUR (p=0.052) were independent predictors of CAPO. However, CPUR had borderline significance. All other Doppler indices were not independent predictors of CAPO. The ability of CPUR alone (AUC=0.65, 95% CI 0.51 to 0.80) to discriminate between GDM pregnancies with and without CAPO was poor.</p><p><strong>Conclusion: </strong>This study shows that there is no significant clinical relationship between fetomaternal Doppler indices and CAPO among pregnancies with GDM. This raises the question regarding the extent to which fetomaternal Doppler indices, which reflect placental function, can be helpful for CAPO prediction in GDM pregnancies.</p>","PeriodicalId":44852,"journal":{"name":"Ultrasound International Open","volume":"11 ","pages":"a25540806"},"PeriodicalIF":1.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christian T Schamberger, Arnold J Suda, Tobias Grossner, Gerhard Schmidmaier, Stephan Stein
{"title":"Sonography-based determination of hip joint anterior head-neck offset is reliable and reproducible for CAM deformity assessment.","authors":"Christian T Schamberger, Arnold J Suda, Tobias Grossner, Gerhard Schmidmaier, Stephan Stein","doi":"10.1055/a-2537-7181","DOIUrl":"https://doi.org/10.1055/a-2537-7181","url":null,"abstract":"<p><strong>Purpose: </strong>Native X-ray, magnetic resonance imaging (MRI), and computed tomography (CT) are standard methods for determining head-neck offset (HNO) in femoro-acetabular impingement (FAI). Our hypothesis was that sonography-assisted determination of the offset in CAM deformity of the hip is a cheap, radiation-free, and reliable alternative to conventional alpha-angle determination.</p><p><strong>Methods: </strong>Patients with hip pain and suspected CAM impingement who underwent anterior-longitudinal hip sonography according to DEGUM standard procedures and MRI were included in this single-center study between January 2015 and December 2019. Offset was determined three times on MRI and sonography by two independent investigators.</p><p><strong>Results: </strong>285 patients were screened and 110 patients (49 females, 61 males) met the inclusion criteria. The mean age at the time of investigation of 54 left and 56 right hip joints was 54.2 years. 1320 measurements were performed. No significant difference in HNO determination between MRI (6.11 mm+/-2.37) and sonography (5.93 mm+/-2.20) could be identified. The mean difference was 0.32 mm+/-0.32 mm (p>0.05) with a maximum deviation of 2.08 mm (outlier).</p><p><strong>Conclusion: </strong>Sonography-assisted determination of head-neck offset is a reliable and reproducible method and is not inferior to determination with MRI. Sonography can be used initially as an alternative or additional tool for the qualitative determination of CAM deformity of the hip joint.</p>","PeriodicalId":44852,"journal":{"name":"Ultrasound International Open","volume":"11 ","pages":"a25377181"},"PeriodicalIF":1.3,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}