Ultrasonics Sonochemistry最新文献

{"title":"Comprehensive analysis of ultrasound-assisted electrohydrodynamic technology on drying characteristics, quality attributes, and volatile profiles of yam (Dioscorea opposita)","authors":"Wurile Bai ,&nbsp;Changjiang Ding ,&nbsp;Jingli Lu ,&nbsp;Chunxu Qin ,&nbsp;Junyi Wang ,&nbsp;Zhiqing Song ,&nbsp;Chuanqiang Che ,&nbsp;Hao Chen","doi":"10.1016/j.ultsonch.2025.107548","DOIUrl":"10.1016/j.ultsonch.2025.107548","url":null,"abstract":"<div><div>In this study, the systematic investigation focused on how varying power levels of ultrasonic (US) pretreatment, when integrated with electrohydrodynamic (EHD) drying, influence the physicochemical properties of yam. Yam samples were subjected to ultrasonic pretreatment at 30 °C for 30 min using power levels of 0 W (Control), 150 W, 180 W, 210 W, 240 W, and 270 W, respectively, followed by drying in an EHD system. During the drying process, a range of metrics were measured, including moisture content, average drying rate, color change, as well as rehydration capacity. Additionally, microstructure was analyzed using infrared spectroscopy while volatile component analysis was conducted. The findings indicated that the amalgamation of ultrasonic pretreatment with EHD drying exhibited statistically significant variations in efficacy across a range of ultrasonic power levels, accompanied by discernible distinctions in comparison to the control group. At 210 W, the sample demonstrated not only a minimal moisture content and the most rapid average drying rate, but also a considerable augmentation in both the effective water diffusion coefficient (1.35-fold in comparison with the control) and the rehydration rate (1.43-fold in comparison with the control), accompanied by statistically significant color differences. This research has revealed for the first time through data analysis on drying characteristics, quality parameters, and volatile components intrinsic quality changes in yam while laying a foundation for food-medicine dual-use materials represented by yam.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"121 ","pages":"Article 107548"},"PeriodicalIF":9.7,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the integration of ultrasonication in hybrid systems for enhanced hydrogen yield","authors":"Slimane Merouani ,&nbsp;Aissa Dehane ,&nbsp;Oualid Hamdaoui","doi":"10.1016/j.ultsonch.2025.107552","DOIUrl":"10.1016/j.ultsonch.2025.107552","url":null,"abstract":"<div><div>This review synthesizes recent developments in ultrasonication (US)/assisted and US/hybrid processes for hydrogen generation, with a focus on US/electrochemical techniques. It summarizes recent findings, discusses existing constraints, and suggests promising routes for further advancement. US/hybrid processes, including US/electrocatalytic techniques and other US-assisted methods, show great promise in improving efficiency and reducing the energy needed for hydrogen generation. The paper emphasizes how ultrasonication can accelerate electrochemical processes, improve mass transfer, and reduce overpotentials. Ultrasonication enhances the physical and chemical parameters of US/electrocatalytic processes by decreasing cell voltage and overpotentials while boosting overall energy efficiency. Other ultrasonication hybrid processes, such as sonocatalysis and US/photocatalysis, have demonstrated the potential to use ultrasonication to activate catalysts and increase hydrogen yields. Notwithstanding these progresses, difficulties remain, such as improving the understanding of the mechanisms underlying US-enhanced hydrogen generation; optimizing operating conditions (e.g., frequency, acoustic power, electrode materials, and solution temperature); and studying hydrogen production from non-aqueous solutions. This review provides a comprehensive framework for future investigation in this evolving field.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"121 ","pages":"Article 107552"},"PeriodicalIF":9.7,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biohybrid Chlorella-HSA with Self-Oxygenation and Dual-Modal activation for synergistic Photo-Sonodynamic immunotherapy","authors":"Chaoli Xu ,&nbsp;Meng Chen ,&nbsp;Yiman Zheng ,&nbsp;Ning Wang ,&nbsp;Wei Lu ,&nbsp;Jinhao Dong ,&nbsp;Aihua Zhang ,&nbsp;Xinhua Ye ,&nbsp;Shouju Wang ,&nbsp;Zhaogang Teng","doi":"10.1016/j.ultsonch.2025.107550","DOIUrl":"10.1016/j.ultsonch.2025.107550","url":null,"abstract":"<div><div>Multimodal dynamic therapies enhance precision oncology by synergistically harnessing reactive oxygen species (ROS)-mediated cytotoxicity, as exemplified in photodynamic and sonodynamic modalities. However, it faces key challenges including hypoxic tumors, low ROS yields, poor deep-tissue penetration, and immunosuppressive niches. To address these challenges, we engineered <em>Chlorella vulgaris</em> (Chl) into a biohybrid platform through sequential integration with 5,10,15,20-tetrakis(4-pyridyl)-21H,23H-porphine tetraiodide (TPP) and human serum albumin (HSA) (termed Chl@TPP/HSA) for synergistic photo-sonodynamic immunotherapy. This system integrates the photosynthetic oxygenation capacity of Chl with the dual photo-sonosensitizing properties of TPP, thereby overcoming hypoxia and amplifying cytotoxic effects. Due to surface functionalization with HSA, tumor-targeted accumulation was improved by 6.4-fold compared with that of unmodified Chl. <em>In vitro</em> and <em>in vivo</em> studies demonstrated that Chl@TPP/HSA under laser and ultrasound (US) irradiation effectively induced immunogenic cell death (ICD), which was marked by high mobility group box 1 (HMGB1) translocation, ATP release, and calreticulin (CRT) exposure. These effects synergistically activated dendritic cell (DC) maturation (42.5 % CD80 + CD86 + increase), enhanced natural killer (NK) cell cytotoxicity (59.5 % upregulation of CD107a + ), promoted cytotoxic CD8 + T-cell infiltration (32.5 % increase), and polarized macrophages toward the M1 phenotype (30.7 % reduction in CD206 + cells). Systemic administration of Chl@TPP/HSA achieved a 91.7 % reduction in tumor volume in the 4 T1 breast cancer model <em>via</em> synergistic photo-sonodynamic immunotherapy. These results establish Chl@TPP/HSA as a multifunctional platform that integrates self-oxygenation, dual-modal ROS generation, and immunomodulation, offering an effective strategy for precision oncology.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"121 ","pages":"Article 107550"},"PeriodicalIF":9.7,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New strategies for tumor diagnosis and therapy with ultrasound assisted by nanomaterials","authors":"Wei Sang ,&nbsp;Haoliang Fan ,&nbsp;Yijun Huang ,&nbsp;Junfeng Zhang ,&nbsp;Weiqi Gao ,&nbsp;Chaoran Zhao ,&nbsp;Xiaoyao Liu ,&nbsp;Linmei Zhao ,&nbsp;Yulong Liu ,&nbsp;Yunlu Dai ,&nbsp;Ruiping Zhang","doi":"10.1016/j.ultsonch.2025.107542","DOIUrl":"10.1016/j.ultsonch.2025.107542","url":null,"abstract":"<div><div>With the development of nanomedicine and ultrasound technology, ultrasound-enhanced contrast agents and treatment platforms based on nanomaterials have become important tools for tumor diagnosis and treatment, owing to their high safety profile, low cost and excellent biocompatibility. This review comprehensively discusses the classification and mechanism of nanomaterials in enhancing ultrasound imaging and treatment. It encompasses organic nanomaterials, including nanobubbles and polymer nanoparticles, and as well as inorganic nanomaterials, such as metal nanoparticles and metal oxide nanoparticles. The application strategies and typical examples of combining nanomaterials with ultrasound technology for different tumors are elaborated, including brain tumors, breast cancer, lung cancer, liver cancer and pancreatic cancer. Numerous studies have demonstrated that integrating ultrasound technology with nano-delivery systems can improve drug delivery efficiency and overcome physiological barriers. This integration can also enhance anti-tumor effects by modulating the tumor immune microenvironment. Despite the significant progress in this field, challenges regarding the biosafety and clinical translation of nanomaterials remain. Future research should concentrate on optimizing the design of nanomaterials and strengthening clinical studies. This will promote the widespread application of ultrasound and nanotechnology in tumor treatment.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"121 ","pages":"Article 107542"},"PeriodicalIF":9.7,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic-assisted separation and extraction of submicron and nano-sized straw particles: Reconstruction of physicochemical characteristics and a promising breakthrough in overcoming technical bottlenecks of straw return to the field","authors":"Xuanming Wang ,&nbsp;Xu Su ,&nbsp;Yanqi Li ,&nbsp;Yu Guan ,&nbsp;Bingchun Yan ,&nbsp;Yuqi Liu ,&nbsp;Jiping Gao ,&nbsp;Qi Wu ,&nbsp;Wenzhong Zhang","doi":"10.1016/j.ultsonch.2025.107538","DOIUrl":"10.1016/j.ultsonch.2025.107538","url":null,"abstract":"<div><div>Addressing the issues of slow decomposition and low nutrient release efficiency associated with traditional straw returning, this study innovatively applied ultrasound-assisted centrifugal separation technology to prepare submicron/nano-straw particles and systematically conducted a multi-scale investigation from microscopic to macroscopic levels. The core finding reveals that when the particle size reaches the 1 μm threshold, ultrasonic cavitation vigorously disrupts the straw structure, leading to efficient lignin removal (77.45 %) and a significant reduction in cellulose crystallinity, thereby fundamentally enhancing the degradation rate. Concurrently, the cavitation effect optimizes elemental ratios (e.g., C, N, and K elemental proportions increasing by 1.05 to 8.50 times) and exposes active functional groups such as C–N and N–H bonds, effectively overcoming the bottleneck in nutrient release. Furthermore, cavitation increases the abundance of hydrophilic groups on the straw surface, enhancing its water-holding capacity by 13.84–18.52 %. Soil columns experiment and pot trials confirmed that the nano-straw prepared by this technology substantially reduces nutrient loss, significantly increases soil available potassium content, ultimately synergistically increasing rice yield by 25.27 %. In summary, by simultaneously optimizing the straw’s degradability, fast-acting nutrient release capacity, and water retention, ultrasonic technology solves the core challenges of traditional straw returning and provides a novel strategy for developing new fast-acting straw fertilizers.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"121 ","pages":"Article 107538"},"PeriodicalIF":9.7,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ultrasonic pretreatment on physicochemical properties and drying behavior of Cunninghamia lanceolata and Eucalyptus grandis × urophylla","authors":"Jing Qian ,&nbsp;Taoyu Han ,&nbsp;Taorong Cheng ,&nbsp;Pengfei Xia ,&nbsp;Zekai Sun ,&nbsp;Chunping Dai ,&nbsp;Jiejie Sun","doi":"10.1016/j.ultsonch.2025.107549","DOIUrl":"10.1016/j.ultsonch.2025.107549","url":null,"abstract":"<div><div>Ultrasonic treatment offers promising potential for improving wood drying efficiency and permeability, yet its effects on the coordinated structural and drying responses of different species remain underexplored. This study assessed the impact of 1–5 h ultrasonic treatments (320 W, 40 kHz) on the physicochemical properties, pore structure, permeability, and drying behavior of <em>Cunninghamia lanceolata</em> and <em>Eucalyptus grandis × urophylla</em>. Results showed that ultrasonic pretreatment did not alter cellulose crystallinity type but reduced crystallinity and free hydroxyl content, while increasing mass loss, microfibril angle, and hygroscopic dimensional stability. With increasing treatment time, cell double wall thickness initially decreased and then stabilized, and Shore hardness declined across all three sections. SEM and MIP analyses revealed that ultrasound gradually disrupted pit membranes, increased the proportion of macro- and mesopores, total pore volume, and porosity, thereby enhancing gas permeability. Treatments of 1–4 h showed the most significant improvements, while excessive treatment (5 h) led to structural collapse or pore closure. Permeability was enhanced by up to about 63 % and 60 % in radial and tangential directions of <em>C. lanceolata</em>, and by about 42 % and 33 % in <em>E. grandis</em>, respectively. Drying time was shortened, and drying rate and diffusion coefficient were increased, while volumetric shrinkage was reduced. Drying rates were raised by about 10 % and 13 % after 2 h (<em>C. lanceolata</em>) and 4 h (<em>E. grandis</em>) treatments, respectively. However, bound water was found to be less responsive to ultrasonic stimulation than free water. These findings provide a theoretical and practical basis for optimizing ultrasonic parameters to improve the drying performance and permeability modification of fast-growing plantation wood.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"121 ","pages":"Article 107549"},"PeriodicalIF":9.7,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel ternary deep eutectic solvent coupled with in-situ-ultrasound synergistic extraction of flavonoids from Epimedium wushanense: machine learning, mechanistic investigation, and antioxidant activity","authors":"Cheng Liu ,&nbsp;Jie Lei ,&nbsp;Xinyu Liu ,&nbsp;Zhaolin Huang ,&nbsp;Ying Zhao","doi":"10.1016/j.ultsonch.2025.107547","DOIUrl":"10.1016/j.ultsonch.2025.107547","url":null,"abstract":"<div><div>This study innovatively developed a novel ternary deep eutectic solvent coupled with in-situ-ultrasound synergistic extraction (TDES-ISUSE)<!--> <!-->method for efficient extraction of total flavonoids (TF) from<!--> <em>Epimedium wushanense</em>. Among 20 prepared DESs, the ternary system composed of choline bitartrate, urea, and glycerol (Chb:Ure:Gly) exhibited the highest extraction efficiency. Response surface methodology-artificial neural network-genetic algorithm (RSM-ANN-GA) optimization identified the optimal extraction parameters: water content of 32 %, vortex time of 10 min, liquid/solid ratio of 34:1 mL/g, ultrasound time of 30 min, and ultrasound power of 270 W. Under these conditions, the TF yield reached<!--> <!-->26.39 ± 0.61 mg/g, which was significantly higher than that of conventional extraction methods. Phytochemical profiling of<!--> <em>E. wushanense</em> <!-->via UHPLC-Q-TOF-MS (positive/negative ion modes) unambiguously annotated 15 compounds, including 9 flavonoids; concurrently, an HPLC method was established for quantitative determination of 4 key flavonoids. FT-IR spectroscopy and nuclear magnetic resonance (NMR)<!--> <!-->confirmed the successful prepared of the novel TDES, while scanning electron microscopy (SEM) and molecular dynamics (MD) simulations elucidated the underlying extraction mechanism, revealing enhanced cell wall disruption and improved solubility of flavonoids in TDES-ISUSE. Antioxidant assays further demonstrated the potential bioactivity of the TF extract. Overall, this work provides an<!--> <!-->eco-friendly, efficient, and reproducible approach<!--> <!-->for extracting bioactive flavonoids from<!--> <em>E. wushanense</em>, with implications for sustainable utilization of medicinal plant resources and advancement of green extraction technologies.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"121 ","pages":"Article 107547"},"PeriodicalIF":9.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Synergistic catalytic effect between ultrasound waves and pyrimidine-2,4-diamine-functionalized magnetic nanoparticles: Applied for synthesis of 1,4-dihydropyridine pharmaceutical derivatives” [Ultrason. Sonochem. 59 (2019) 104737]","authors":"Reza Taheri-Ledari,&nbsp;Jamal Rahimi,&nbsp;Ali Maleki","doi":"10.1016/j.ultsonch.2025.107478","DOIUrl":"10.1016/j.ultsonch.2025.107478","url":null,"abstract":"","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"120 ","pages":"Article 107478"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advantages of ultrasonic-assisted extraction over hot water extraction for polysaccharides from waste stems of Rubia cordifolia L.: A comprehensive comparison of efficiency, structure, and bioactivity.","authors":"Guanjun Ye, Jiangfei Li, Jiayu Wang, Ting Ju, Zhilong Zhou, Jianlong Wang, Haitian Zhao, Yingyu Zhou, Weihong Lu","doi":"10.1016/j.ultsonch.2025.107502","DOIUrl":"10.1016/j.ultsonch.2025.107502","url":null,"abstract":"<p><p>Rubia cordifolia L. (RCL) is a plant with both commercial and medicinal values, widely distributed worldwide. Its roots have been used to treat various diseases, including abnormal uterine bleeding, arthritis, and kidney stones. However, its stems are often overlooked and regarded as waste. This study employed response surface methodology to optimize the ultrasonic-assisted extraction (UAE) process for polysaccharides from RCL waste stems (RCLP), and compared energy consumption and carbon emissions with hot water extraction (HWE). The underlying mechanism of UAE for polysaccharide extraction was further explored. Additionally, the physicochemical properties and in vitro activities of RCLP extracted by UAE (UAE-P) and HWE (HWE-P) were evaluated and compared. The results showed that the optimal UAE conditions were as follows: temperature of 52.5 °C, extraction time of 43 min, power of 310 W, and liquid-to-solid ratio of 32 mL/g, yielding 5.97 ± 0.34 % of RCLP. Compared with HWE, UAE significantly improved extraction efficiency, with a 640.18 % increase in production rate and a 93.23 % reduction in specific energy. UAE promoted the exposure of cell wall functional groups (e.g., C=O, C-O-C) and disintegration of the crystalline structure, thereby enhancing extraction efficiency. UAE-P exhibited higher uronic acid content, smaller and more uniform particle size, and better stability than HWE-P. These structural characteristics were significantly correlated with superior in vitro antioxidant and hypoglycemic activities, as well as stronger bile salt binding capacity. In conclusion, this study highlights that UAE is a feasible method for efficiently extracting high-value polysaccharides from RCL waste stems.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"120 ","pages":"107502"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing phenolic and flavonoid recovery from Vietnamese balm using green solvent-based ultrasonic-enzymatic-assisted extraction","authors":"Tan Phat Vo ,&nbsp;Thi Hoang Trang Nguyen ,&nbsp;Ha Bao Tran Nguyen ,&nbsp;Hoang Nhan Nguyen ,&nbsp;Nguyen Van Nhi Le ,&nbsp;Minh Hoa Ha ,&nbsp;Gia Bao Pham ,&nbsp;Dinh Quan Nguyen","doi":"10.1016/j.ultsonch.2025.107546","DOIUrl":"10.1016/j.ultsonch.2025.107546","url":null,"abstract":"<div><div>The research explored the extraction of phenolic and flavonoids from <em>Elsholtzia ciliata</em> (Vietnamese balm) using a natural deep eutectic solvent (NADES)-based ultrasonic-enzymatic-assisted extraction (UAE-EAE) technique. A range of NADESs was evaluated to investigate the most suitable solvent system. The NADES synthesized from lactic acid and choline chloride provided the highest recovery of phenolics and flavonoids. Single-factor experiments were conducted to assess how individual process variables influence the recovery of phenolics and flavonoids. Key factors affecting extraction performance were assessed using the Plackett-Burman approach. Optimal conditions were established through the Box-Behnken Design model. The optimal extraction parameters for TPhC were determined as a solid-to-liquid ratio (SLR) of 1:59 g/mL, water content (WC) of 12 %, ultrasonic temperature of 43 °C, ultrasonic time of 6.88 min, and incubation time of 6.33 min. For TFlC, the optimal conditions were established at SLR of 1:67 g/mL, WC of 14 %, and enzyme activity of 1.28 U/g. Under these optimized conditions, UAE-EAE achieved the maximum recovery of total phenolic content (36.41 ± 2.50 mg GAE/g) and total flavonoid content (18.74 ± 1.28 mg QE/g). A second-order kinetic model was adopted to analyze the extraction mechanism. Structural and surface changes in the plant matrix before and after extraction were further investigated using scanning electron microscopy (SEM) and X-ray diffraction (XRD). This method demonstrates high efficiency and eco-friendliness in extracting plant-derived bioactive compounds using NADES-based UAE-EAE.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"121 ","pages":"Article 107546"},"PeriodicalIF":9.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}