Ultrasonics Sonochemistry最新文献

{"title":"Ultrasound-assisted extraction and value of active substances in Muxu","authors":"Huilin Wang,&nbsp;Laiqing Deng,&nbsp;Gangliang Huang","doi":"10.1016/j.ultsonch.2024.107220","DOIUrl":"10.1016/j.ultsonch.2024.107220","url":null,"abstract":"<div><div>This article reviews the latest research progress on ultrasound-assisted extraction of active substances from Muxu, including polysaccharides, polyphenols, leaf proteins, anthocyanins, total flavonoids, and total saponins, in order to provide theoretical references for the extraction of active substances from Muxu. At the same time, its medicinal value, feeding value, ecological value, edible value, and ornamental value were analyzed and summarized. Flavonoids, saponins, and polysaccharides in the bioactive substances of Muxu have good effects on improving animal productivity, enhancing immune function, and improving animal health. Especially when applied to broiler chickens and laying hens, it can improve the quality of meat and eggs and increase the economic benefits of breeding. In addition, there are other beneficial substances in Muxu, such as natural pigments, coumarins, leaf protein, and chlorogenic acid, which also play an important role in livestock and poultry production and health status.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"113 ","pages":"Article 107220"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerating maturation of Chinese rice wine by using a 20 L scale multi-sweeping-frequency mode ultrasonic reactor and its mechanism exploration","authors":"Zhuofan He ,&nbsp;Furong Hou ,&nbsp;Yansheng Du ,&nbsp;Chunhua Dai ,&nbsp;Ronghai He ,&nbsp;Haile Ma","doi":"10.1016/j.ultsonch.2025.107229","DOIUrl":"10.1016/j.ultsonch.2025.107229","url":null,"abstract":"<div><div>The formation of flavor in traditional Chinese rice wine requires a long aging process. To accelerate the maturation of rice wine, a 20 L scale multi-sweeping- frequency mode ultrasonic reactor was employed in this study to explore the promoting effects. Rice wines were subjected under 10 combined types of sonication treatments with 20/28/40 kHz in single/double/triple frequencies, and in fixed or sweeping modes, respectively. Then samples were aged in room temperature for up to 180 days. A 7.3 % increase of total esters content was observed in rice wine sample after treated by a fixed 40 kHz ultrasonication with 50 W/L intensity at 30 °C for 15 min, compared with the untreated sample. After sonication and stored for six months, 286.78 % increase of the volatile esters was found, compared to rice wine without ultrasoinc treatment and stored at same condition for same time. And the total volatile alcohol substances and total volatile aldehydes in rice wine decreased by 12.95 % and 67.46 %, while the total volatile acids increased by 17.11 %, respectively. The research results also demonstrated that ultrasonic induced free radicals accounted for the variations of rice wine properties. And the correlation between the acoustic cavitation and the flavor formation was also observed.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"113 ","pages":"Article 107229"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of hydrodynamic cavitation combined with snail enzyme treatment on the structure and functional properties of water-soluble dietary fiber in rice husks","authors":"Zhigang Quan ,&nbsp;Mingming Chen ,&nbsp;Dongjie Zhang","doi":"10.1016/j.ultsonch.2025.107236","DOIUrl":"10.1016/j.ultsonch.2025.107236","url":null,"abstract":"<div><div>In this study, we adopted the synergistic modification technology of hydrodynamic cavitation and snail enzyme, to improve the yield and activity of soluble dietary fibers (SDFs) of rice husk. The physicochemical properties, structural changes, and inhibition of α-glucosidase and α-amylase of SDFs were examined <em>in vitro</em>. This synergistic treatment significantly increased the yield of SDFs to 18.64 % ± 0.16 %, significantly reduced the particle size to 122.33 ± 0.26 nm, and significantly increased the specific surface area to 1.718 ± 0.002 m²/g. The absolute value of the zeta potential significantly increased to −36.39 ± 0.12 mV, indicating an excellent solution stability and gel-forming ability. At the same time, the water-holding, oil-holding, and swelling capacities were significantly enhanced, reaching 8.52 ± 0.09 g/g, 4.85 ± 0.29 g/g, and 7.29 ± 0.25 mL/g, respectively. Structural analysis showed that the synergistic treatment destroyed the fiber structure, produced a large number of small molecule fragments, and significantly changed the monosaccharide components and functional group distribution. Functional evaluation showed that the inhibitory effect of CE-SDF on α-glucosidase and α-amylase was significantly enhanced, and enzymatic reaction kinetic analysis revealed that both enzymes were competitive inhibitors, with IC₅₀ values of 2.893 and 1.727 mg/mL, respectively. In summary, the synergistic modification of hydrodynamic cavitation and snail enzyme greatly optimized the structural and functional properties of rice husk SDFs, providing a theoretical basis for its application in the field of hypoglycemic drugs and functional foods.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"113 ","pages":"Article 107236"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of power ultrasound on the quality of leafy green produce through a multifrequency, multimode, modulated system","authors":"Bin Zhou ,&nbsp;J. Atilio de Frias ,&nbsp;Yaguang Luo ,&nbsp;Jorge M. Fonseca ,&nbsp;Hao Feng","doi":"10.1016/j.ultsonch.2024.107221","DOIUrl":"10.1016/j.ultsonch.2024.107221","url":null,"abstract":"<div><div>Ultrasound technology has been increasingly explored as an eco-friendly method to improve the microbial safety of leafy greens. However, its effect on produce quality is critical, and considerable knowledge gaps remain in this area. The present study examined the response of leafy greens to ultrasound treatment as shown by tissue damage and sensory quality, using a novel multifrequency, multimode, modulated (MMM) system to address the issue of nonuniform ultrasound field distribution. Iceberg lettuce, romaine lettuce, spinach, loose leaf lettuce and Lollo Rosso were subjected to different ultrasonication durations (1–16 min) in a MMM tubular treatment unit at 34 kHz and subsequently stored at 1 °C for three weeks. Sensory evaluations by a trained panel and electro-conductivity rate measurements were conducted to assess produce quality over time. Ultrasound treatment at an acoustic power density below 80 W/L had no significant effect (P &gt; 0.05) on the overall sensory quality of leafy greens during 14 days of storage. Even though the electro-conductivity rate, an indicator of tissue damage, increased in ultrasound-treated samples compared to control, it did not result in perceptible changes in sensory attributes.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"113 ","pages":"Article 107221"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piezocatalysis-combined advanced oxidation processes for organic pollutant degradation in water system","authors":"Heejin Yang ,&nbsp;Chang-Gu Lee ,&nbsp;Jechan Lee","doi":"10.1016/j.ultsonch.2024.107219","DOIUrl":"10.1016/j.ultsonch.2024.107219","url":null,"abstract":"<div><div>The piezoelectric catalyst process has emerged as a promising technology for energy harvesting, effectively converting natural mechanical energies, such as wind, water flow, and waves, into usable electrical energy using piezoelectric materials. In recent years, there has been a growing interest in applying this technology to water treatment to address environmental challenges. Concurrently, research efforts have focused on enhancing the efficiency of piezoelectric catalysis by integrating it with advanced oxidation processes (AOPs). This combination has demonstrated significantly better performance than traditional single-process methods. This review offers a comprehensive overview of the fundamental principles of piezocatalysis and explores the evolution of research in this field. It provides a detailed analysis of how piezocatalysis has been developed and applied, particularly in water treatment. The review also includes a comparative assessment of various processes used to remove organic pollutants from water, focusing on recent advancements that combine piezocatalysis with AOPs. Furthermore, the limitations of the current research were discussed, and future research directions were suggested based on the overall findings. By summarizing the progress and challenges in this area, the review aims to provide valuable insights and guide future studies to enhance the effectiveness and application of piezoelectric catalysis in environmental remediation.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"113 ","pages":"Article 107219"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The accurate determination of Perfluorooctane sulfonic acid (PFOS) removal efficiency by integrated-sonochemical system","authors":"Debabrata Panda ,&nbsp;Maxime Cochennec ,&nbsp;Stéfan Colombano ,&nbsp;Benjamin Laulier ,&nbsp;Pascal Tierce ,&nbsp;Alexandre Baudouard ,&nbsp;Sebastian Bristeau ,&nbsp;Anne Togola ,&nbsp;Julie Lions ,&nbsp;Nicolas Devau ,&nbsp;Eric D. van Hullebusch","doi":"10.1016/j.ultsonch.2025.107222","DOIUrl":"10.1016/j.ultsonch.2025.107222","url":null,"abstract":"<div><div>Perfluorooctanesulfonic acid (PFOS) is one of the most investigated Per- and polyfluoroalkyl substances (PFAS) for being the strongest compound to eliminate and having adverse health concerns. In this work, we have conducted the sonochemical treatment of PFOS simulated water under high (500 kHz) and low (22 kHz) frequencies while monitoring the operational parameters via an integrated sonochemical system. The integrated advanced sonochemical system includes software to monitor treatment power, solution temperature and frequency while allowing distinctive control of the reaction conditions. Considering the lack of calorimetric measurements in earlier studies and the difficulty in achieving comparative outcomes, precise calorimetric measurements and determination of electrical energy per order (E_EO) were performed in this study. The complete PFOS removal was achieved under 500 kHz frequency with optimum parameters including initial pollutant concentration (5 mg/L), ultrasound power density (400 W/L) and solution temperature (25 °C) within 180 min of treatment. The removal and mineralization extents (defluorination) were determined by ultra-high performance liquid chromatography–mass spectrometry (UPLC-MS/MS) and ion-chromatography (IC) analysis. Under optimum conditions, 100 % removal and 99 % mineralization were achieved. The rate constant (k) ranged from 0.011 to 0.031 <span><math><msup><mrow><mi>m</mi><mi>i</mi><mi>n</mi></mrow><mrow><mo>-</mo><mn>1</mn></mrow></msup></math></span> (first-order reaction), which increased with the increase in the power density. While the solution temperature did not significantly affect the PFOS removal efficiency, the initial concentration was found to have a prominent effect on the reaction rate constant. However, experiments at low frequency (22 kHz) showed negligible removal efficiency. The specific energy requirement for reaching 90 % removal while considering the power consumed by the ultrasonic system from the main electrical source was determined to be 700 <span><math><mrow><mi>k</mi><mi>W</mi><mi>h</mi><mo>/</mo><msup><mrow><mi>m</mi></mrow><mn>3</mn></msup></mrow></math></span>, which is much lower than other reported work under similar conditions. This work will be useful for both laboratory and industrial upscaling while acting as a benchmark reference to follow.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"113 ","pages":"Article 107222"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing ultrasound for the extraction of polysaccharides from the tuber of Typhonium giganteum Engl.: Extraction conditions, structural characterization and bioactivities","authors":"Xi Peng ,&nbsp;Jing-Ya Wang ,&nbsp;Kui-Xu Gao,&nbsp;Zhi-Kun Wang,&nbsp;Qiao-Ling Deng,&nbsp;Yao Wang,&nbsp;Mei-Bian Hu,&nbsp;Yu-Jie Liu","doi":"10.1016/j.ultsonch.2025.107243","DOIUrl":"10.1016/j.ultsonch.2025.107243","url":null,"abstract":"<div><div>Polysaccharides from the dried tuber of <em>Typhonium giganteum</em> Engl. (TGEPs) were obtained by utilizing ultrasonic-assisted extraction (UAE) as the extraction method. The determination of optimal process parameters for the UAE of TGEPs (TGEP-U) was accomplished through the application of response surface methodology (RSM). The structural characteristics, antioxidant and hypoglycemic effects of TGEP-U and TGEPs obtained by hot water extraction (TGEP-H) were then compared. Consequently, the optimum extraction conditions predicted by RSM for TGEP-U were obtained as adding water at a ratio of 31 mL/g and extracted for 32 min under an ultrasound power of 440 W. In the verification experiment, the actual yield of TGEP-U was 7.32 ± 0.18 %. It was found that UAE could increase the yield and the total sugar content of TGEPs. Meanwhile, chemical composition analysis showed that both TGEP-U and TGEP-H were mainly composed of mannose, rhamnose, glucuronic acid, galacturonic acid, glucose, galactose, arabinose, and fucose, but the monosaccharide molar ratios were changed by UAE. Analysis of molecular weight (Mw) revealed the presence of three primary constituents within TGEP-U, and four main components in TGEP-H, and UAE reduced the average Mw of TGEPs. No obvious difference was found in the Fourier transform infrared spectroscopy analysis of TGEP-U and TGEP-H. The Congo red and Circular dichroism tests demonstrated that TGEP-U and TGEP-H had non-three helical structure. Scanning electron microscope observation further revealed that the aggregation of functional groups within TGEPs may be influenced by ultrasound, thereby affecting their powder morphology. TGEP-U has slightly poorer thermal stability than TGEP-H, which may be affected by ultrasonic cavitation effects. The results also indicated that TGEP-U had better antioxidant and hypoglycemic activity than TGEP-H. In summary, UAE is an effective method to extract and enhance the activity of TGEPs with enormous research value and potentials.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"113 ","pages":"Article 107243"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Process, dynamics and bioeffects of acoustic droplet vaporization induced by dual-frequency focused ultrasound","authors":"Yubo Zhao,&nbsp;Yi Feng,&nbsp;Liang Wu","doi":"10.1016/j.ultsonch.2025.107234","DOIUrl":"10.1016/j.ultsonch.2025.107234","url":null,"abstract":"<div><div>Acoustic droplet vaporization (ADV) plays a crucial role in ultrasound-related biomedical applications. While previous models have examined the stages of nucleation, growth, and oscillation in isolation, which may limit their ability to fully describe the entire ADV process. To address this, our study developed an integrated model that unifies these three stages of ADV, stimulated by a continuous nonlinear dual-frequency ultrasound wave. Using this integrated model, we investigated the influence of nonlinear dual-frequency ultrasound parameters on ADV dynamics and bioeffects by incorporating tissue viscoelasticity through parametric studies. Our results demonstrated that the proposed model accurately captured the entire ADV process, ensuring continuous vapor bubble formation and evolution throughout the phase transition process. Moreover, the applied unified theory for bubble dynamics can simulate intense bubble collapse with high Mach Number as a result of the nonlinear effects of dual-frequency ultrasound. In addition, cavitation-associated mechanical and thermal damage appeared to be more strongly correlated with rapid bubble collapse than with maximum bubble size. Our research also revealed that the mechanical and thermal effects could be regulated independently to some extent by adjusting dual-frequency ultrasound parameters, as they presented differing sensitivities to frequency and acoustic power. Importantly, dual-frequency combinations such as 1.5 MHz + 3 MHz (fundamental and second harmonic), which exhibit a higher Degree of Nonlinearity (DoN) can extend bubble lifespan, offering a potential pathway to the efficacy of ultrasound treatments.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"113 ","pages":"Article 107234"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional nanocrystal as effective contrast agents for dual-mode imaging: Live-cell sonoluminescence and contrast-enhanced echography","authors":"V. Vighetto ,&nbsp;E. Pascucci ,&nbsp;N.M. Percivalle ,&nbsp;A. Troia ,&nbsp;K.M. Meiburger ,&nbsp;M.R.P. van den Broek ,&nbsp;T. Segers ,&nbsp;V. Cauda","doi":"10.1016/j.ultsonch.2025.107242","DOIUrl":"10.1016/j.ultsonch.2025.107242","url":null,"abstract":"<div><div>In the context of molecular imaging, the present work explores an innovative platform made of lipid-coated nanocrystals as contrast-enhanced agent for both ultrasound imaging and sonoluminescence. At first, the dynamics of gas bubbles generation and cavitation under insonation with either pristine or lipid-coated nanocrystals (ZnO-Lip) are described, and the differences between the two colloidal systems are highlighted. These ZnO-Lip show an unprecedented ability to assist cavitation, which is reflected in enhanced sonoluminescent light emission with respect to the pristine nanocrystals or the pure water. Highly defined and sharp sonoluminescent images of cultured cells are indeed obtained, for the first time, when ZnO-Lip are used. Furthermore, ZnO-Lip were adopted as a nanosized agent for contrast-enhanced ultrasound imaging, i.e. echography, first in solutions, and then on ex-vivo tissues. A prolonged over time and bright imaging effect is observed when adopting the developed nanoparticles. Furthermore, their nanometric size and potential targeting with biomolecules would allow ease extravasation and tissue or even cell penetration, achieving enhanced-contrast imaging. Finally, the stimuli-responsive therapeutic applications of ZnO-Lip against tumors is overviewed, aiming to achieve a fully theranostic approach.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"113 ","pages":"Article 107242"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-assisted enzyme extraction of Dendrobium Officinale polysaccharides: Extraction process, characterization, immunomodulatory effects","authors":"Hengpu Zhou ,&nbsp;Yingjie Dong ,&nbsp;Zhangyun Wu ,&nbsp;Xi Peng,&nbsp;Meiqiu Yan,&nbsp;Suhong Chen,&nbsp;Guiyuan Lv","doi":"10.1016/j.ultsonch.2025.107248","DOIUrl":"10.1016/j.ultsonch.2025.107248","url":null,"abstract":"<div><div>Dendrobium Officinale is a traditional Chinese medicinal and edible herb, and polysaccharides being its principal active components. We employed ultrasonic-assisted enzymatic extraction to obtain polysaccharides from Dendrobium Officinale (DOP) and optimized the extraction process using the GA-BP method. Subsequently, DOP was characterized using HPLC, SEM, and HPGPC. Finally, an immunocompromised mouse model induced by cyclophosphamide was adopted to evaluate the immunomodulatory effects. The results showed that the optimal extraction process of ultrasound-assisted enzyme method was 102 min ultrasonic extraction time, 48 °C extraction temperature, 1:80 material-liquid ratio, and 1600 U/g enzyme additions. The predicted polysaccharide yield was 29.64 %, and the actual polysaccharide yield was 29.71 ± 0.31 %. DOP is a white powder with pore-like structure, whose polysaccharide content is 90.66 ± 2.47 %, and with a composition of D-mannose, glucose, galactose, arabinose in a molar ratio of 74.17: 47.80: 9.03: 1. DOP has demonstrated the ability to improve the general condition of mice with cyclophosphamide-induced immunosuppression. It mitigates damage to the thymus and spleen tissues, increases white blood cell counts, regulates the ratio of T lymphocytes and the levels of related factors, enhances macrophage phagocytic function to improve nonspecific immune responses, and boosts the levels of immunoglobulins IgA and IgG to enhance specific immune function. Therefore, DOP can alleviate immunosuppression induced by cyclophosphamide.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"114 ","pages":"Article 107248"},"PeriodicalIF":8.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}