Ultrasonics Sonochemistry最新文献

Ultrasound-triggered piezoelectric biomaterials for enhanced cancer sonodynamic immunotherapy 超声触发压电生物材料增强癌症声动力免疫治疗

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-29 DOI: 10.1016/j.ultsonch.2025.107402

Yongke Bai , Kehua Jiang , Wen Deng , Jiaquan Mao , Jian Wu , Zichen Zhong , Xiaozhuo Ba , Yonghua Tong , Yu He , Yuan Chen , Kun Tang

{"title":"Ultrasound-triggered piezoelectric biomaterials for enhanced cancer sonodynamic immunotherapy","authors":"Yongke Bai , Kehua Jiang , Wen Deng , Jiaquan Mao , Jian Wu , Zichen Zhong , Xiaozhuo Ba , Yonghua Tong , Yu He , Yuan Chen , Kun Tang","doi":"10.1016/j.ultsonch.2025.107402","DOIUrl":"10.1016/j.ultsonch.2025.107402","url":null,"abstract":"<div><div>Compared to traditional tumor treatment modalities, such as radiotherapy, chemotherapy, and surgical intervention, tumor immunotherapy offers potential benefits by enhancing the immune system’s functionality, diminish immune evasion, and establish enduring immune memory, ultimately aiming for the destruction or eradication of tumor cells. However, the intricate tumor microenvironment (TME) poses challenges for immunotherapy due to its suppressive effects on immune cell activity, leading to issues such as low immune responsiveness and insufficient targeting. Sonodynamic immunotherapy (SDT) emerges as an innovative therapeutic approach， where sonosensitizers localize around tumor cells and, upon ultrasound (US) stimulation, generate substantial reactive oxygen species (ROS). This mechanism facilitates targeted tumor cell killing and enhances treatment specificity. ROS also induce immunogenic cell death (ICD) through various pathways, bolstering the immune response. Recent research suggests that piezoelectric biomaterials, used as sonosensitizers, can amplify the anti-tumor effects of SDT. The piezoelectric effect of these materials enhances ROS production efficiency, improves the TME, mitigates immune cell suppression, and promotes ICD. This review article provides an overview of piezoelectric biomaterials classification, introduce the piezoelectric effect, and examines the applications of piezoelectric biomaterials in sonodynamic immunotherapy. It serves as a reference for the development of piezoelectric materials and the advancement of tumor treatment strategies.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"119 ","pages":"Article 107402"},"PeriodicalIF":8.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonic pre-treatment on the replacement of high concentration of cadmium(Ⅱ) by aluminum powder: Effect and mechanism 超声波预处理对铝粉替代高浓度镉（Ⅱ）的影响及机理

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-28 DOI: 10.1016/j.ultsonch.2025.107406

Tian Wang , Yuanru Wang , Hongtu Ji , Yimin Zhang , Deyang Song , Phan Duc Lenh , Thiquynhxuan Le , Libo Zhang

{"title":"Ultrasonic pre-treatment on the replacement of high concentration of cadmium(Ⅱ) by aluminum powder: Effect and mechanism","authors":"Tian Wang , Yuanru Wang , Hongtu Ji , Yimin Zhang , Deyang Song , Phan Duc Lenh , Thiquynhxuan Le , Libo Zhang","doi":"10.1016/j.ultsonch.2025.107406","DOIUrl":"10.1016/j.ultsonch.2025.107406","url":null,"abstract":"<div><div>Cadmium (Cd) is a toxic metal with significant recycling value. Our previous work demonstrated that ultrasonic-enhanced Cd<sup>2+</sup> replacement by aluminum (Al) powder outperforms non-sonicated methods, yet challenges remain in treating high-concentration Cd<sup>2+</sup> solutions. This study introduces an ultrasonic pre-treatment for Al powder to enhance Cd<sup>2+</sup> replacement in high-concentration solutions. The effects of pre-treatment time, temperature, pH, and ultrasonic power density on the replacement efficiency were systematically investigated. Under optimized conditions, the Cd<sup>2+</sup> replacement degree increased by 20.7 % compared to non-pre-treated Al and 3.87 % compared to conventionally pre-treated Al, reaching 97.53 %. Ultrasound corrodes the Al powder’s oxide film, reducing its inhibition on electron release and creating a favorable atmosphere for enhanced replacement. The specific surface area of ultrasonically pre-treated Al powder increased by 35 % and 92 % compared to conventionally pre-treated and non-pre-treated Al, respectively, enhancing Cd<sup>2+</sup> reaction. This process enables efficient treatment of higher Cd<sup>2+</sup> concentrations (300 % increase) with lower Al powder consumption (40 % decrease), making it more suitable for industrial-scale, efficient, clean, and sustainable production.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"119 ","pages":"Article 107406"},"PeriodicalIF":8.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonication-mediated fabrication of artificial oleosomes from hemp seed oil-body proteins and rose essential oil for banana preservation 以大麻籽油体蛋白和玫瑰精油为原料制备香蕉保存用人工油质体

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-28 DOI: 10.1016/j.ultsonch.2025.107407

Haoran Zhu , Yuhan Cao , Xinyu Zhang , Qin Hu , Feng Xue

{"title":"Ultrasonication-mediated fabrication of artificial oleosomes from hemp seed oil-body proteins and rose essential oil for banana preservation","authors":"Haoran Zhu , Yuhan Cao , Xinyu Zhang , Qin Hu , Feng Xue","doi":"10.1016/j.ultsonch.2025.107407","DOIUrl":"10.1016/j.ultsonch.2025.107407","url":null,"abstract":"<div><div>This study systematically evaluates the efficacy of three emulsification strategies (ultrasonication, high-pressure homogenization, and high-speed shearing) in fabricating artificial oleosomes (AOs) stabilized by hemp seed oil body proteins (OBPs) and rose essential oil. Comparative analyses revealed that ultrasonication generated AOs with superior physicochemical attributes, including reduction in mean particle size, higher ζ-potential, and increased surface hydrophobicity compared to conventional methods. These structural enhancements correlated with improved functional performance: ultrasonicated AOs exhibited lower apparent viscosity, higher radical scavenging capacity, and reduction in light transmittance. Coatings derived from ultrasonicated AOs demonstrated exceptional barrier properties, achieving better water vapor permeability inhibition and oxygen transmission reduction relative to other coatings. Practical validation on bananas revealed that ultrasonicated AOs coatings extended shelf life through enzymatic browning suppression, moisture retention and content of soluble solids maintaining. The findings establish ultrasonication as a scalable strategy for engineering multifunctional AOs with applications in sustainable food preservation.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"119 ","pages":"Article 107407"},"PeriodicalIF":8.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical etching of metals and minerals using ultrasound in deep eutectic solvents 用超声波在深共晶溶剂中电化学蚀刻金属和矿物

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-27 DOI: 10.1016/j.ultsonch.2025.107403

Philip Hunt , Jennifer M. Hartley , Muwafaq A. Rabeea , Andrew P. Abbott , Christopher E. Elgar

{"title":"Electrochemical etching of metals and minerals using ultrasound in deep eutectic solvents","authors":"Philip Hunt , Jennifer M. Hartley , Muwafaq A. Rabeea , Andrew P. Abbott , Christopher E. Elgar","doi":"10.1016/j.ultsonch.2025.107403","DOIUrl":"10.1016/j.ultsonch.2025.107403","url":null,"abstract":"<div><div>This study compares the anodic dissolution of two iron-based alloys, mild steel and an FeNdB super magnet, with that of a mineral, chalcopyrite (CuFeS<sub>2</sub>), in a deep eutectic solvent formed from choline chloride and ethylene glycol under silent and ultrasonic conditions. These three materials have different granular morphologies and heterogeneities. The aim was to show how a combination of ultrasound and electrochemistry can lead to different etching mechanisms through increased mass transport by the mechanical action of bubbles at the electrode surface. Linear sweep and cyclic voltammetries showed that both alloys passivated on the anodic sweep. Using ultrasound significantly decreases passivation, but does not fully prevent it as was previously proposed. Partial passivation produces enhanced pitting and anisotropic etching of all grains. Where the alloy grains are heterogeneous, as is the case with FeNdB, anisotropic etching can lead to surface fragmentation under certain conditions, with partial grains being dislodged from the surface without dissolution. In this case, selective dissolution of the Nd-rich phase was observed. Cyclic voltammetry of chalcopyrite showed several anodic redox processes under silent conditions, but the use of ultrasound led to a linear current–voltage response with a roughly 15-fold increase in the current. Electrochemical etching occurs around grain boundaries, making the material more prone to further ultrasonic fragmentation. This led to a rapid separation of the copper-rich phase from the largely silica-based gangue phase. The surface was inert under just insonation, demonstrating the importance of the anisotropic electrochemical etching process. This approach could be used for the purification of minerals.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"119 ","pages":"Article 107403"},"PeriodicalIF":8.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the inhibitory mechanism of combined ultrasound and capsaicin against Listeria monocytogenes 超声联合辣椒素对单核增生李斯特菌抑制机制的研究

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-25 DOI: 10.1016/j.ultsonch.2025.107399

Ying Yang , Yuzhang Zhu , Yue Feng , Shuyao Zhao , Khalfan Khalfan Mohd , Cen Li , Jing Jin , Lincheng Zhang , Shuoqiu Tong , Yongjun Wu

{"title":"Study on the inhibitory mechanism of combined ultrasound and capsaicin against Listeria monocytogenes","authors":"Ying Yang , Yuzhang Zhu , Yue Feng , Shuyao Zhao , Khalfan Khalfan Mohd , Cen Li , Jing Jin , Lincheng Zhang , Shuoqiu Tong , Yongjun Wu","doi":"10.1016/j.ultsonch.2025.107399","DOIUrl":"10.1016/j.ultsonch.2025.107399","url":null,"abstract":"<div><div><em>Listeria monocytogenes</em> (LM) is a critical foodborne pathogen, whose exceptional environmental adaptability and biofilm-forming capacity render it resistant to effective control during food processing and storage. Sonodynamic therapy (SDT), as an emerging sterilization approach, has rapidly emerged demonstrating potent microbicidal efficacy against microorganisms. The development of novel sonosensitizers is of crucial significance for the further advancement and application of SDT. This study is the first to demonstrate that capsaicin acts as a sonosensitizer, significantly enhancing its anti-LM efficacy under ultrasound irradiation. Results demonstrate that ultrasound combined with capsaicin treatment effectively eliminates LM, suppresses its motility, and impedes biofilm formation and adhesion. This study elucidates capsaicin’s antibacterial mechanism as a sonosensitizer against LM, showing that ultrasound combined with capsaicin treatment substantially elevates bacterial oxidative stress levels, increases cell membrane permeability, disrupts cellular architecture, and induces damage to bacterial DNA and proteins, ultimately leading to bacterial death. Molecular mechanism analysis indicates that Ultrasonic-activated capsaicin treatment significantly downregulates genes associated with bacterial quorum sensing systems and motility. Through its application in milk, its potential as an effective bactericide was further demonstrated.</div><div>This study not only provides novel strategies for the prevention and control of LM and its biofilms but also offers a critical theoretical foundation and practical guidance for developing natural sonosensitizers, which paves the way for broader applications of sonodynamic technology in food safety and microbial control.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"119 ","pages":"Article 107399"},"PeriodicalIF":8.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of ultrasound treatment on physicochemical, sensory, and structural properties of cold brew coffee 超声处理对冷冲咖啡理化、感官及结构特性的影响

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-24 DOI: 10.1016/j.ultsonch.2025.107401

Youngji Lee, Kwang-Geun Lee

{"title":"Effects of ultrasound treatment on physicochemical, sensory, and structural properties of cold brew coffee","authors":"Youngji Lee, Kwang-Geun Lee","doi":"10.1016/j.ultsonch.2025.107401","DOIUrl":"10.1016/j.ultsonch.2025.107401","url":null,"abstract":"<div><div>This study investigated the effects of ultrasound treatment (UT) on the physicochemical, sensory, and structural properties of cold brew coffee. Among the examined physicochemical properties, colour changed to a light caramel shade following UT, while pH, total dissolved solids, and extraction yield increased compared to the control group. Total polyphenol content, flavonoid content, antioxidant activity, and lipid content significantly increased (<em>p</em> < 0.05) with higher UT amplitudes and longer treatment durations, with the highest values observed after 15 min of treatment at 90 % amplitude at 20 °C. Analysis of non-volatile compounds revealed that caffeine content increased by up to 54.7 %, trigonelline by 26.8 %, and chlorogenic acid by 67.4 % under UT conditions. Sensory analysis identified a total of 32 volatile compounds, with the highest levels detected in samples treated for 5 min at 30 % amplitude at 4 °C. Sensory evaluation results indicated that UT samples exhibited decreased sweetness and acidity, while burnt taste and body intensity increased. Structurally, droplet size was reduced by up to 89.4 % compared to the control group, and scanning electron microscopy images revealed numerous distinct holes and irregular pores formed during UT. These findings suggest that UT has the potential to enhance cold brew coffee manufacturing by improving efficiency in terms of both time and processing conditions.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"119 ","pages":"Article 107401"},"PeriodicalIF":8.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visibly acoustic delivery of IR808 into tumor via gas vesicles enhances photothermal therapy efficacy against tumor 可见，通过气体囊泡将IR808声学传递到肿瘤中可增强光热治疗肿瘤的疗效

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-24 DOI: 10.1016/j.ultsonch.2025.107398

Xin Meng , Yanan Feng , Yuanyuan Wang , Chen Lin , Wei Wang , Sutian Zhu , Bing Guo , Huaiyu Wang , Litao Sun , Fei Yan

{"title":"Visibly acoustic delivery of IR808 into tumor via gas vesicles enhances photothermal therapy efficacy against tumor","authors":"Xin Meng , Yanan Feng , Yuanyuan Wang , Chen Lin , Wei Wang , Sutian Zhu , Bing Guo , Huaiyu Wang , Litao Sun , Fei Yan","doi":"10.1016/j.ultsonch.2025.107398","DOIUrl":"10.1016/j.ultsonch.2025.107398","url":null,"abstract":"<div><div>Photothermal therapy (PTT) has emerged as a promising new approach in tumor treatment, with the great advantages including non-invasiveness and temporal controllability. However, the effective delivery of photothermal agents into tumor remains a significant challenge, limiting its clinical translational application. In this study, we developed a kind of photothermal agents modified with gas vesicles (GVs), greatly facilitating ultrasound/fluorescence imaging-guided delivery of photothermal agents and enhancing the efficacy of photothermal therapy. The GVs were synthesized and extracted from <em>Halobacterium NRC-1</em>, followed with modification with IR808. The resulting GVs-IR808 were able to be visually tracked by ultrasound and fluorescence imaging. Upon their arrival at the tumor area after systemic administration, ultrasound irradiation was applied to induce the cavitation of GVs-IR808, greatly promoting IR808 delivery into the tumor. The subsequent laser irradiation was applied and resulted in a significant inhibition of tumor growth. In conclusion, our study provides a novel approach for ultrasound/fluorescence dual-modal imaging-guided photothermal treatment of breast tumors.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"119 ","pages":"Article 107398"},"PeriodicalIF":8.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emulsifying properties of Maillard reaction products formed using spirulina (Arthrospira maxima) protein extract coupled with various saccharides 螺旋藻（Arthrospira maxima）蛋白提取物与各种糖类偶联形成美拉德反应产物的乳化特性

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-23 DOI: 10.1016/j.ultsonch.2025.107397

Dohyoung Lee, Kwang-Geun Lee

{"title":"Emulsifying properties of Maillard reaction products formed using spirulina (Arthrospira maxima) protein extract coupled with various saccharides","authors":"Dohyoung Lee, Kwang-Geun Lee","doi":"10.1016/j.ultsonch.2025.107397","DOIUrl":"10.1016/j.ultsonch.2025.107397","url":null,"abstract":"<div><div>This study investigated the effects of Maillard reactions using various saccharides (gum arabic, dextrin, glucose) and ultrasonication on the emulsifying and physicochemical properties of spirulina protein extract. At the same heating time, ultrasound-assisted samples exhibited higher degrees of glycation up to 87.45 % than conventional heating samples for all types of saccharides. The emulsifying activity index maximized by 45.6 % compared to the control in gum arabic-based Maillard reaction products (MRPs) under ultrasound-assisted heating for 90 min. However, the emulsion stability index minimized by 89.5 % in dextrin-based MRPs under ultrasound-assisted heating for 90 min. A total of 20 volatile compounds were identified in the MRPs. Total volatiles maximized by 58.4 % compared to the control in dextrin-based MRPs after heating without ultrasonication for 5 h. In brief, gum arabic is more suitable than other saccharides for improving the emulsifying properties of spirulina protein extract MRPs, and ultrasound-assisted heating can accelerate Maillard reaction.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"119 ","pages":"Article 107397"},"PeriodicalIF":8.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient recovery of procyanidins from grape residue by UAE-NADES and macroporous resin 用UAE-NADES和大孔树脂高效回收葡萄渣中的原花青素

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-23 DOI: 10.1016/j.ultsonch.2025.107400

Changsen Wang, Yilin You, Weidong Huang, Jicheng Zhan

引用次数: 0

Optimization of ultrasound enzyme-assisted trehalose lipid extraction of Coptis alkaloids and evaluation of its anti-inflammatory effects 超声酶辅助海藻糖脂提取黄连生物碱的工艺优化及抗炎作用评价

IF 8.7 1区化学

Ultrasonics Sonochemistry Pub Date : 2025-05-23 DOI: 10.1016/j.ultsonch.2025.107396

Huiwen Wang , Haixin Peng , Wenwen Ding , Zhiyun Zhang , Yadan Zheng , Sikai Chen , Xueying Chen , Qianwei Qu , Yanyan Liu , Yanhua Li

{"title":"Optimization of ultrasound enzyme-assisted trehalose lipid extraction of Coptis alkaloids and evaluation of its anti-inflammatory effects","authors":"Huiwen Wang , Haixin Peng , Wenwen Ding , Zhiyun Zhang , Yadan Zheng , Sikai Chen , Xueying Chen , Qianwei Qu , Yanyan Liu , Yanhua Li","doi":"10.1016/j.ultsonch.2025.107396","DOIUrl":"10.1016/j.ultsonch.2025.107396","url":null,"abstract":"<div><div>Coptidis Rhizoma (CR), a traditional Chinese medicine, has extensive pharmacological activity because it is rich in isoquinoline alkaloids. Nonetheless, the limited solubility of these alkaloids presents a significant challenge, hindering the full realization of CR’s therapeutic potential through conventional extraction methods. To address this issue and enhance the solubility of the target compounds while optimizing extraction efficiency, this study employed an environmentally sustainable extraction technique, Ultrasound-Enzyme-Trehalose Lipid (UET), to synergistically extract five key alkaloids from CR. Based on the results of single-factor experiments, Box-Behnken design (BBD) was employed to optimize the selected model variables. The optimal extraction conditions were determined: extraction pH of 4.3, extraction temperature of 40 ℃, solid–liquid ratio of 1:27 g/mL, and ultrasonication time of 48 min. UET extracts were compared with other extracts, and it was proved that UET extracts had higher alkaloid extraction rate, comprehensive evaluation value (CEV) and lower energy consumption and CO<sub>2</sub> emission. Then scanning electron microscopy (SEM), dynamic light scattering (DLS) and transmission electron microscopy (TEM) were used to explore the extraction mechanism of UET extraction. In addition, UET extraction has more excellent anti-inflammatory activity. The establishment of UET method of CR provides a method reference for green and efficient extraction of alkaloid components from natural drugs.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"119 ","pages":"Article 107396"},"PeriodicalIF":8.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0