Ultrasonics Sonochemistry最新文献

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Construction of nanodelivery system based on the interaction mechanism between ultrasound–treated soybean whey protein and quercetin: structure, physicochemical stability and bioaccessibility
IF 8.4 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-12-10 DOI: 10.1016/j.ultsonch.2024.107195
Xinru Cao, Jia Cao, Tianhe Xu, Lexi Zheng, Jingyi Dai, Xiaokun Zhang, Tian Tian, Kunyu Ren, Xiaohong Tong, Huan Wang, Lianzhou Jiang
{"title":"Construction of nanodelivery system based on the interaction mechanism between ultrasound–treated soybean whey protein and quercetin: structure, physicochemical stability and bioaccessibility","authors":"Xinru Cao, Jia Cao, Tianhe Xu, Lexi Zheng, Jingyi Dai, Xiaokun Zhang, Tian Tian, Kunyu Ren, Xiaohong Tong, Huan Wang, Lianzhou Jiang","doi":"10.1016/j.ultsonch.2024.107195","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107195","url":null,"abstract":"In this study, soybean whey protein (SWP) nanodelivery system was constructed through ultrasound treatment and quercetin (Que) modification. The effect of ultrasound power on the interaction mode between SWP and Que, and the formation and stability of SWP–Que nanodelivery system were investigated. Optimal ultrasound treatment (300–500 W) produced SWP–Que nanoparticles with smaller particle size, higher ζ–potential values, and more uniform dispersion. Fluorescence spectroscopy and FTIR analyses revealed that SWP primarily binds to Que through hydrophobic interactions. Ultrasound treatment induced the unfolding of the SWP structure, thereby increasing its binding affinity to Que. After 400 W sonication, the encapsulation efficiency can reach 95.63 ± 0.60 %. The SWP–Que nanoparticles protected Que from degradation under environmental stresses (heat, UV, and storage) and improved its bioaccessibility during digestion as the ultrasonic power of 400 W. This study highlights the potential of ultrasound–modified SWP nanoparticles for effective nutrient delivery.","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"142 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of ultrasound assisted pretreatment and drying methods on quality characteristics of underutilized vegetable purslane.
IF 8.7 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-12-09 DOI: 10.1016/j.ultsonch.2024.107194
Tajali Assad, Zahida Naseem, Sajad Mohd Wani, Aisha Sultana, Iqra Bashir, Tawheed Amin, Fauzia Shafi, B S Dhekale, Imtiyaz Tahir Nazki, Imtiyaz Zargar, A Raouf Malik, Tawfiq Alsulami, Robert Mugabi, Gulzar Ahmad Nayik
{"title":"Impact of ultrasound assisted pretreatment and drying methods on quality characteristics of underutilized vegetable purslane.","authors":"Tajali Assad, Zahida Naseem, Sajad Mohd Wani, Aisha Sultana, Iqra Bashir, Tawheed Amin, Fauzia Shafi, B S Dhekale, Imtiyaz Tahir Nazki, Imtiyaz Zargar, A Raouf Malik, Tawfiq Alsulami, Robert Mugabi, Gulzar Ahmad Nayik","doi":"10.1016/j.ultsonch.2024.107194","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107194","url":null,"abstract":"<p><p>The present study was aimed to determine the effect of ultrasound pretreatment and different drying methods viz sun drying, solar drying, cabinet drying, vacuum drying, microwave assisted drying and freeze drying on physicochemical, phytochemical activity, rehydration ratio and drying time of the purslane. The purslane was ultrasonicated for 15, 30, 45 and 60 min following by drying. The ultrasound pretreatment (60 min) combined with freeze drying retained the highest antioxidants (95.59 %), phenolic content (7.85 mgGAE/100 g), total carotenoid content (99.74 mg/100 g), ascorbic acid (399.94 mg/100 g) and rehydration ratio (6.80). Moreover, the same combination revealed higher L and a* values when compared with other drying methods. However, the purslane pretreated with ultrasonication for 60 min and then dried via microwave took less time for drying. This study suggests that Ultrasound pretreatment (60 min) followed by freeze drying is recommended for preserving the nutritional and functional properties of purslane. It could be scaled up for commercial applications in the functional food and nutraceutical industries, where high-quality preservation is crucial.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"112 ","pages":"107194"},"PeriodicalIF":8.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extraction of tiger nut oil using ultrasound-assisted immiscible binary solvents and its effect on the quality of extracted oil and starch.
IF 8.7 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-12-09 DOI: 10.1016/j.ultsonch.2024.107191
Zhi-Cheng Li, Zhen-Shan Zhang, Ying Xia, Jin-Tao Han, Hua-Zhang Chang, Hui-Min Wang
{"title":"Extraction of tiger nut oil using ultrasound-assisted immiscible binary solvents and its effect on the quality of extracted oil and starch.","authors":"Zhi-Cheng Li, Zhen-Shan Zhang, Ying Xia, Jin-Tao Han, Hua-Zhang Chang, Hui-Min Wang","doi":"10.1016/j.ultsonch.2024.107191","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107191","url":null,"abstract":"<p><p>Tiger nuts are rich in both oil and starch. In this paper, an immiscible binary solvent consisted of water and hexane was used to separate oil and starch from tiger nut with the assistance of ultrasound. The effects of various factors including ultrasonic power, ultrasonic time, extraction temperature, water-hexane ratio and solid-liquid ratio on the oil yield were examined. The oil and starch obtained were characterized and compared with those obtained through conventional methods, such as mechanical pressing (MP) and solvent extraction (SE). The results indicated that all examined factors, especially water-hexane ratio significantly affected the oil yield. Under the optimum conditions, ultrasound-assisted immiscible binary solvent extraction (UASE) yielded more oil than SE and MP. The quality analysis revealed that the acid value and iodine value of UASE oil were comparable to those extracted using the MP and SE methods, but the peroxide value was lower, and the vitamin E content was higher. In addition, the starch from tiger nut after UASE exhibited lower viscosity, greater solubility and swelling power, and better thermal and freeze-thaw stability. This study demonstrated that the UASE method is an efficient and environmentally friendly technique for simultaneously extracting oil and starch from tiger nuts.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"112 ","pages":"107191"},"PeriodicalIF":8.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring ultrasound-induced free radical formation: A comparative study in water and sour cherry juice using glutathione and terephthalic acid indicators.
IF 8.7 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-12-09 DOI: 10.1016/j.ultsonch.2024.107193
Nursena Aktı, Semanur Yildiz
{"title":"Exploring ultrasound-induced free radical formation: A comparative study in water and sour cherry juice using glutathione and terephthalic acid indicators.","authors":"Nursena Aktı, Semanur Yildiz","doi":"10.1016/j.ultsonch.2024.107193","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107193","url":null,"abstract":"<p><p>This study aims to assess free radical (FR) generation potential of ultrasound in water and sour cherry juice (SCJ) model systems using an indirect method with specific indicators including glutathione (GSH), a well-known antioxidant, and terephthalic acid (TPA), which fluoresces upon oxidation. Initially, aqueous GSH solutions were subjected to ultrasound at varying amplitudes (60 % and 80 %) for up to 30 min using probes of different diameters (13 mm and 19 mm) to identify maximal oxidation conditions. FR formation was monitored using UPLC equipped with diode array detector and fluorescence spectrophotometer for GSH and TPA oxidation, respectively. Increasing sonication time decreased GSH and increased oxidized glutathione (GSSG) in water for both probes; however, the 19 mm probe generated five times more GSSG than the 13 mm, implying a substantially higher rate of FR formation. Subsequently, ultrasound was applied to aqueous TPA solution using the 19 mm probe-representing the more challenging conditions-at a previously optimized amplitude (67 %) during 30 min. Time-course water samples showed a steady increase in TPA fluorescence intensity with longer sonication durations, suggesting that oxidation reactions driven by FRs were progressing over time in water. Following sonication of GSH- and TPA-added SCJ under the same conditions, analysis by LC-QTOF-MS and fluorescence spectrophotometry revealed no GSSG or fluorescence formation, confirming the absence of notable oxidation of both indicators, likely due to the juice's complex composition (e.g., presence of antioxidant compounds). This study offers key insights into how ultrasound conditions affect FR formation in water and SCJ media by stabilizing them in detectable forms.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"112 ","pages":"107193"},"PeriodicalIF":8.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Micro-jet formation induced by the interaction of a spherical and toroidal cavitation bubble.
IF 8.7 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-12-06 DOI: 10.1016/j.ultsonch.2024.107185
Jaka Mur, Alexander Bußmann, Thomas Paula, Stefan Adami, Nikolaus A Adams, Rok Petkovsek, Claus-Dieter Ohl
{"title":"Micro-jet formation induced by the interaction of a spherical and toroidal cavitation bubble.","authors":"Jaka Mur, Alexander Bußmann, Thomas Paula, Stefan Adami, Nikolaus A Adams, Rok Petkovsek, Claus-Dieter Ohl","doi":"10.1016/j.ultsonch.2024.107185","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107185","url":null,"abstract":"<p><p>We investigate experimentally and numerically the interaction between a spherical cavitation bubble and a wall-bounded toroidal cavitation bubble. We demonstrate that shock wave focusing following toroidal bubble initiation induces the formation of micro-jets that pierce the spherical bubble in the torus-axis direction away from the surface, strongest in the anti-phase scenario. The velocity of micro-jets is determined by the initial standoff distance of the spherical bubble from the wall and thus from the toroidal bubble, with peak jet velocities approaching 1000m/s. The micro-jets are triggered by the complex interaction between the torus shock wave and the surface of the spherical bubble. Additionally, the formation of secondary cavitation appears to significantly enhance the micro-jets compared to scenarios without secondary cavitation. Following the formation of micro-jets, a subsequent broad jet pierces the spherical bubble, marking the onset of its collapse. After the collapse, we observe an amplified rebound phase resulting in a more than twofold increase of the bubble volume compared to the initial bubble.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"112 ","pages":"107185"},"PeriodicalIF":8.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental investigation on the effect of concentration on the resonance frequency of lipid coated ultrasonically excited microbubbles. 浓度对脂质包覆超声激发微气泡共振频率影响的实验研究。
IF 8.7 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-12-05 DOI: 10.1016/j.ultsonch.2024.107170
Hossein Haghi, Mahshid Yaali, Agata A Exner, Michael C Kolios
{"title":"Experimental investigation on the effect of concentration on the resonance frequency of lipid coated ultrasonically excited microbubbles.","authors":"Hossein Haghi, Mahshid Yaali, Agata A Exner, Michael C Kolios","doi":"10.1016/j.ultsonch.2024.107170","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107170","url":null,"abstract":"<p><p>This study presents an experimental investigation of the influence of MB concentration on the resonance frequency of lipid-coated microbubbles (MBs). Expanding on theoretical models and numerical simulations from previous research, this work experimentally investigates the effect of MB size on the rate of resonance frequency increase with concentration, a phenomenon observed across MBs with two different lipid compositions: propylene glycol (PG) and propylene glycol and glycerol (PGG). Employing a custom-designed ultrasound attenuation measurement setup, we measured the frequency-dependent attenuation of MBs, isolating MBs based on size to generate distinct monodisperse sub-populations for analysis. The resonance frequency of MBs was determined by identifying the attenuation peak in the broadband attenuation ultrasound attenuation measurements. Our experimental findings confirm that larger MBs (≈2.1μm) demonstrate a more significant shift in resonance frequency (≈ 5 MHz, ≈ 40%) as a function of MB concentration. In contrast, smaller MBs (≈1.3μm) show a minor shift in the resonant frequency (≈ 1.8 MHz, ≈ 8%), underlining the importance of size in determining acoustic behavior compared to changes in the lipid shell properties. Additionally, we observed that resonance frequency increase with concentration reaching a saturation point at higher concentrations. This plateau occurs at higher concentrations for larger MBs (≈2.1μm), while smaller MBs (≈1.6μm and ≈1.3μm) reach this saturation point at lower concentrations. Furthermore, the study highlights the small effect of bubble-bubble interactions on the resonance frequency of MB populations, particularly at lower MB concentrations and for smaller MBs. This insight is important for applications utilizing MB clusters, such as contrast-enhanced ultrasound imaging and MB-mediated therapies. While both size and lipid shell composition influence resonance frequency, MB size has a more significant effect. In conclusion, our findings affirm the need to consider both MB size and concentration when utilizing MBs for clinical and industrial ultrasonic applications.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"112 ","pages":"107170"},"PeriodicalIF":8.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasonic treatment-assisted reductive deposition of Cu and Pd nanoparticles on ultrathin 2D Bi2S3 nanosheets for selective electrochemical reduction of CO2 into C2 compounds.
IF 8.7 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-12-05 DOI: 10.1016/j.ultsonch.2024.107189
Bilal Masood Pirzada, Faisal AlMarzooqi, Ahsanulhaq Qurashi
{"title":"Ultrasonic treatment-assisted reductive deposition of Cu and Pd nanoparticles on ultrathin 2D Bi<sub>2</sub>S<sub>3</sub> nanosheets for selective electrochemical reduction of CO<sub>2</sub> into C<sub>2</sub> compounds.","authors":"Bilal Masood Pirzada, Faisal AlMarzooqi, Ahsanulhaq Qurashi","doi":"10.1016/j.ultsonch.2024.107189","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107189","url":null,"abstract":"<p><p>In this work, we have ultrasonically deposited Cu and Pd nanoparticles on Bi<sub>2</sub>S<sub>3</sub> nanoparticles, prepared using an ultrasonication assisted hydrothermal method. We implemented intense ultrasonic waves bearing frequency of 20 kHz and power of 750 W at the acoustic wavelength of 100 mm to reduce Cu and Pd nanoparticles on the Bi<sub>2</sub>S<sub>3</sub> surface. The XRD confirmed the formation of highly crystalline Bi<sub>2</sub>S<sub>3</sub> nanoparticles with a pure orthorhombic phase and the deposition of copper (Cu<sup>o</sup>) and palladium (Pd<sup>o</sup>) nanoparticles was indicated by the strengthening and broadening of the peaks. XPS also confirmed the formation of Cu<sup>o</sup> and Pd<sup>o</sup> nanoparticles on Bi<sub>2</sub>S<sub>3</sub>. The Transmission Electron Microscopy (TEM) also exhibited the deposition of Cu and Pd nanoparticles on the Bi<sub>2</sub>S<sub>3</sub> nanosheets which was further confirmed using high resolution TEM analysis. The electrochemical CO<sub>2</sub> reduction by Cu-Pd/Bi<sub>2</sub>S<sub>3</sub> electrocatalyst using Cu foam as the conducting support led to the formation of acetaldehyde and ethylene as the major products. The rate of formation of ethylene was found to be 488.5 μ mol g<sup>-1</sup>h<sup>-1</sup> at an applied potential of -0.6 V (vs. RHE), with the best Faradaic efficiency of 57.09 % at -0.4 V (vs. RHE). Among the liquid phase products, acetaldehyde was the major product showing the maximum Faradaic efficiency of 6.473 % at -0.2 V (vs. RHE), with a total formation rate of 64.27 μ mol g<sup>-1</sup>h<sup>-1</sup>. The results revealed that the Cu-Pd/Bi<sub>2</sub>S<sub>3</sub> electrocatalyst was more selective to C<sub>2</sub> products while the pure Bi<sub>2</sub>S<sub>3</sub> nanoparticles majorly produced C<sub>1</sub> compounds.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"112 ","pages":"107189"},"PeriodicalIF":8.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reversible Ca2+ signaling and enhanced paracellular transport in endothelial monolayer induced by acoustic bubbles and targeted microbeads
IF 8.4 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-12-02 DOI: 10.1016/j.ultsonch.2024.107181
Jiawei Lin, Chaofeng Qiao, Hao Jiang, Zhihui Liu, Yaxin Hu, Wei Liu, Yu Yong, Fenfang Li
{"title":"Reversible Ca2+ signaling and enhanced paracellular transport in endothelial monolayer induced by acoustic bubbles and targeted microbeads","authors":"Jiawei Lin, Chaofeng Qiao, Hao Jiang, Zhihui Liu, Yaxin Hu, Wei Liu, Yu Yong, Fenfang Li","doi":"10.1016/j.ultsonch.2024.107181","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107181","url":null,"abstract":"Ultrasound and microbubble mediated blood brain barrier opening is a non-invasive and effective technique for drug delivery to targeted brain region. However, the exact mechanisms are not fully resolved. The influences of Ca<ce:sup loc=\"post\">2+</ce:sup> signaling on sonoporation and endothelial tight junctional regulation affect the efficiency and biosafety of the technique. Therefore, an improved understanding of how ultrasound evokes Ca<ce:sup loc=\"post\">2+</ce:sup> signaling in the brain endothelial monolayer, and its correlation to endothelial permeability change is necessary. Here, we examined the effects of SonoVue microbubbles or integrin-targeted microbeads on ultrasound induced bioeffects in brain microvascular endothelial monolayer using an acoustically-coupled microscopy system, where focused ultrasound exposure and real-time recording of Ca<ce:sup loc=\"post\">2+</ce:sup> signaling and membrane perforation were performed. Microbubbles induced robust Ca<ce:sup loc=\"post\">2+</ce:sup> responses, often accompanied by cell poration, while ultrasound with microbeads elicited reversible Ca<ce:sup loc=\"post\">2+</ce:sup> response without membrane poration. At the conditions evoking reversible Ca<ce:sup loc=\"post\">2+</ce:sup> signaling, intracellular Ca<ce:sup loc=\"post\">2+</ce:sup> release and reactive oxygen species played key roles for microbubbles induced Ca<ce:sup loc=\"post\">2+</ce:sup> signaling while activation of mechanosensitive ion channels was essential for the case of microbeads. Trans-well diffusion analysis revealed significantly higher <ce:italic>trans</ce:italic>-endothelial transport of 70 kDa FITC-dextran for both integrin-targeted microbeads and microbubbles compared to the control group. Further immunofluorescence staining showed disruption of cell junctions with microbubble stimulation and reversible remodeling of many cell junctions by ultrasound with integrin-targeted microbeads. This investigation provides new insights for ultrasound induced Ca<ce:sup loc=\"post\">2+</ce:sup> signaling and its influence on endothelial permeability, which may help develop new strategies for safe and efficient drug/gene delivery in the vascular system.","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"37 1","pages":""},"PeriodicalIF":8.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasound-triggered drug release and cytotoxicity of microbubbles with diverse drug attributes.
IF 8.7 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-12-01 DOI: 10.1016/j.ultsonch.2024.107182
Chi-Fen Chuang, Chia-Wei Lin, Chih-Kuang Yeh
{"title":"Ultrasound-triggered drug release and cytotoxicity of microbubbles with diverse drug attributes.","authors":"Chi-Fen Chuang, Chia-Wei Lin, Chih-Kuang Yeh","doi":"10.1016/j.ultsonch.2024.107182","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107182","url":null,"abstract":"<p><p>Ultrasound (US)-triggered cavitation of drug-loaded microbubbles (MBs) represents a promising approach for targeted drug delivery, with substantial benefits attainable through precise control over drug release dosage and form. This study investigates Camptothecin-loaded MBs (CPT-MBs) and Doxorubicin-loaded MBs (DOX-MBs), focusing on how properties such as hydrophilicity, hydrophobicity, and charged functional groups affect their interaction with the lipid surfaces of MBs, thereby influencing the fundamental characteristics and acoustic properties of the drug-loaded MBs. In comparison to DOX-MBs, CPT-MBs showed larger MB size (2.2 ± 0.3 and 1.4 ± 0.1 μm, respectively), a 2-fold increase in drug loading, and an 18 % reduction in leakage after 2 h at 37℃. Under 1 MHz US with a 100 ms pulse repetition interval (PRI), 1000 cycles, 5-minute duration, and 550 kPa acoustic pressure, CPT-MBs undergo inertial cavitation, while DOX-MBs undergo stable cavitation. Drug particles released from these MBs under US-induced cavitation were analyzed using dynamic light scattering, NanoSight, cryo-electron microscopy, and density gradient ultracentrifugation. Results showed that CPT-MBs mainly release free CPT, while DOX-MBs release multilayered DOX-lipid aggregates. The cytotoxicity to C6 cells induced by US-triggered cavitation of these two types of MBs also differed. DOX-lipid aggregates delayed initial uptake, leading to less pronounced short-term (2 h) effects compared to the rapid release of free CPT from CPT-MBs. These findings underscore the need to optimize drug delivery strategies by fine-tuning MB composition and US parameters to control drug release kinetics and achieve the best tumoricidal outcomes.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"112 ","pages":"107182"},"PeriodicalIF":8.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasonic-assisted MoS2/GO/TiO2 ceramic coatings: Enhancing anti-friction performance through dual-interface optimization.
IF 8.7 1区 化学
Ultrasonics Sonochemistry Pub Date : 2024-11-30 DOI: 10.1016/j.ultsonch.2024.107180
Ziwei Guo, Yongnan Chen, Nan Wang, Yiku Xu, Qinyang Zhao, Zhimin Hou, Guangrui Gao, Yan Kang, Haifei Zhan
{"title":"Ultrasonic-assisted MoS<sub>2</sub>/GO/TiO<sub>2</sub> ceramic coatings: Enhancing anti-friction performance through dual-interface optimization.","authors":"Ziwei Guo, Yongnan Chen, Nan Wang, Yiku Xu, Qinyang Zhao, Zhimin Hou, Guangrui Gao, Yan Kang, Haifei Zhan","doi":"10.1016/j.ultsonch.2024.107180","DOIUrl":"https://doi.org/10.1016/j.ultsonch.2024.107180","url":null,"abstract":"<p><p>Ceramic coatings containing two-dimensional materials (2D materials) provide effective protection for light alloys during wear, significantly improving their anti-friction performance. MoS<sub>2</sub> has proven highly effective in enhancing the anti-friction performance of ceramic coatings, particularly when synthesized via plasma electrolytic oxidation (PEO). However, dislocation pinning due to the incoherent interfaces in MoS<sub>2</sub>/TiO<sub>2</sub> coatings tends to cause localized stress concentrations and brittle fracture, requiring effectively improve nanomechanical properties by optimizing interface design. To address these issues, this study used ultrasonic-assisted PEO to disperse graphene oxide (GO), which provided more possibility for in-situ synthesis MoS<sub>2</sub>, ultimately resulting in MoS<sub>2</sub> with modified interlayer spacing. The change in interlayer spacing induced dislocation evolution at incoherent interface, leading to dual interface formation. At MoS<sub>2</sub> (0.534 nm)/TiO<sub>2</sub> interface: dislocation dipoles evolve to create considerable distortion, facilitating releasing shear stresses and inhibiting crack propagations. This process is followed by dislocation annihilation, keeping to stable interfacial bonding. Additionally, the others form strong dislocation pinning to obstruct dislocation slip and enhancing deformation resistance at MoS<sub>2</sub> (0.227 nm)/TiO<sub>2</sub> interface. The combined effects of dual interfacial enhancements resulted in a 90.0 % reduction in friction coefficients of the MoS<sub>2</sub>/GO/TiO<sub>2</sub> coating compared to the traditional ceramic coating. This facile technique provides a new strategy to fabricate self-lubricating ceramic coatings on light alloys, while the introduction of ultrasound during PEO offers valuable guidance for applying ultrasound in the synthesis of 2D materials.</p>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"112 ","pages":"107180"},"PeriodicalIF":8.7,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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