Ultrasonics Sonochemistry最新文献

{"title":"Efficient extraction of bioactive compounds from Momordica charantia L. fruits using ultrasound-assisted extraction and response surface methodology optimization","authors":"Juthaporn Ponphaiboon ,&nbsp;Wantanwa Krongrawa ,&nbsp;Sontaya Limmatvapirat ,&nbsp;Chutima Limmatvapirat","doi":"10.1016/j.ultsonch.2025.107709","DOIUrl":"10.1016/j.ultsonch.2025.107709","url":null,"abstract":"<div><div>This study optimized ultrasound-assisted extraction (UAE) conditions to maximize bioactive compounds from <em>Momordica charantia</em> L. (Okinawan bitter melon) fruit using response surface methodology (RSM). A three-factor, three-level Box-Behnken design assessed the effects of acoustic intensity, duty cycle, and extraction time on extraction yield, total phenolic content (TPC), antioxidant activity (DPPH and FRAP assays), α-glucosidase inhibitory activity, and charantin content. Acoustic intensity had the greatest impact, followed by duty cycle and extraction time. The optimal conditions were 85 W·cm⁻² acoustic intensity, 0.83 s⁻¹ duty cycle, and 13.20 min extraction time, yielding 35.80 % extract, 847.91 mg GAE/100 g extract TPC, IC₅₀ of DPPH at 119.08 µg/mL, FRAP value of 148.76 mg AAE/g extract, α-glucosidase inhibition of 41.60 mg acarbose/g extract, and charantin content of 5.83 mg/g extract. Experimental values closely matched predictions, confirming model validity. This optimized UAE method provides an efficient approach for extracting bioactive compounds from <em>M. charantia</em> L., ensuring high yield and biological activity. The findings offer valuable insights for industrial-scale extraction and potential applications in functional foods, pharmaceuticals, and nutraceuticals.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107709"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145732608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid-gas phase-change nanoplatforms for ultrasound-mediated cancer theranostics","authors":"Jin Lei,&nbsp;Jing Lin,&nbsp;Peng Huang","doi":"10.1016/j.ultsonch.2025.107719","DOIUrl":"10.1016/j.ultsonch.2025.107719","url":null,"abstract":"<div><div>Ultrasound has emerged as a powerful modality for cancer theranostics due to its noninvasiveness, deep-tissue penetration, and real-time feedback. However, the limited stability and short circulation time of traditional microbubble contrast agents restrict their clinical potential. Liquid-gas phase-change nanoplatforms, also known as phase-change contrast agents (PCCAs), offer a promising alternative by enabling acoustic-triggered vaporization of perfluorocarbon (PFC) cores, facilitating enhanced imaging performance and spatiotemporally controlled therapeutic functions. This review introduces the fundamental mechanisms underlying the liquid–gas phase transition, including acoustic cavitation, heating, and radiation force effects. It then summarizes the design strategies for PCCAs, covering PFC core selection (from low- to high-boiling-point types), diverse carrier platforms (lipid-, polymer-, and nanoemulsion-based systems), and surface functionalization approaches for targeted delivery and stimulus responsiveness. Subsequently, the applications of PCCAs in ultrasound-guided cancer theranostics are discussed, encompassing their roles in diagnostic imaging as well as in ultrasound-mediated mono- and combination therapies, such as chemotherapy, phototherapy, and immunotherapy. Finally, the review concludes with current challenges and future perspectives on smart material integration, multimodal imaging, and precision delivery strategies, which will be key to unlocking the full potential of PCCAs in cancer diagnosis and treatment.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107719"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Assisted Deep Eutectic Solvent-Based Extraction of Polysaccharides from Okra: Optimization by Response Surface Methodology and Artificial Neural Network Modeling","authors":"Muhammad Imran ,&nbsp;Chih-Huang Weng ,&nbsp;Girma Sisay Wolde ,&nbsp;Ying-Chen Chen ,&nbsp;Yi-Jin Wu ,&nbsp;Shang-Ming Huang ,&nbsp;Yao-Tung Lin","doi":"10.1016/j.ultsonch.2025.107715","DOIUrl":"10.1016/j.ultsonch.2025.107715","url":null,"abstract":"<div><div>Plant-derived polysaccharides are critical bioactive compounds; however, conventional extraction methods are often inefficient, energy-intensive, and may compromise their bioactivity. Ultrasound-assisted deep eutectic solvent (UA-DES) extraction offers a greener alternative by integrating acoustic cavitation with tunable solvent properties; however, optimization remains complex due to the interaction of multiple processing variables. This study reports a novel application of ultrasound-assisted deep eutectic solvent (UA-DES) extraction for okra polysaccharides (OPs), with process optimization using response surface methodology (RSM) and artificial neural network (ANN) modeling to identify optimal conditions and clarify nonlinear extraction behavior. Among the tested DES systems, choline chloride–citric acid (CCA) exhibited the highest extraction performance. Single-factor experiments and RSM identified sonication time and liquid–solid ratio as key variables. The ANN model achieved higher predictive accuracy than RSM and captured nonlinear and synergistic parameter interactions that were not evident in traditional response surfaces, providing deeper insight into process behavior. Under optimized conditions (2 h, 80 °C, 190 W, 60 mL/g), UA-DES extraction produced 23.56 % OPs and 80.75 % DPPH• scavenging activity, representing 94 % higher yield and 28 % greater antioxidant activity than hot-water ultrasonic (HWU) extraction. UA-DES-derived OPs contained higher contents of uronic acids, total sugars, and glucans, and uniquely included arabinose absent in HWU extracts. Structural analyses revealed pyranose configurations, amorphous crystallinity, and porous microstructures, which collectively contribute to improved solubility and bioactivity. Overall, UA-DES extraction using CCA provides an eco-efficient strategy for producing high-value okra polysaccharides. The integrated RSM–ANN framework enables precise optimization and enhanced mechanistic understanding, supporting UA-DES as a scalable, green technology for the production of functional polysaccharides.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107715"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous ultrasound-microwave assisted deep eutectic solvent extraction of essential oil from calamansi (Citrus × microcarpa) peel: optimization, volatile profiling, and antioxidant activities","authors":"Zhiheng Zhao ,&nbsp;Yijun Liu ,&nbsp;Hua Chen ,&nbsp;Xin Jia ,&nbsp;Lijun Yin ,&nbsp;Xiaoping Hu ,&nbsp;Xue Lin","doi":"10.1016/j.ultsonch.2025.107730","DOIUrl":"10.1016/j.ultsonch.2025.107730","url":null,"abstract":"<div><div>Calamansi (<em>Citrus × microcarpa</em>) peel, a byproduct of juice processing, is often discarded, leading to resource waste and environmental issues. This study developed an eco-friendly and efficient method for extracting essential oil (EO) from calamansi peel using deep eutectic solvent (DES) combined with simultaneous ultrasound-microwave-assisted steam distillation (DES-UM-SD). Through screening ten DES formulations and eight extraction methods, choline chloride-lactic acid (ChCl-LA) was identified as the optimal solvent, and DES-UM-SD was selected as the most effective method. The optimal extraction conditions were determined as follows: DES water content of 55.4 %, solid–liquid ratio of 1:4, ultrasonic power of 432 W for 30 min, and microwave treatment at 52 °C and 300 W for 30 min. Under these conditions, the EO yield reached 1.76 % ± 0.02 %, a 120 % increase over conventional steam distillation (0.80 % ± 0.02 %). Scanning electron microscopy (SEM) revealed different effects of ultrasound, microwave and DES on the peel’s microstructure. A total of 139 volatile compounds were identified based on gas chromatography-mass spectrometry (GC–MS) analysis, with D-limonene as the most abundant. The DES-UM-SD-extracted EO exhibited the highest antioxidant activity in DPPH and FRAP assays and moderate ABTS scavenging capacity. Correlation analysis indicated that DES altered the profile of minor volatile compounds, influencing antioxidant properties. This work provides a sustainable strategy for high-value utilization of calamansi peel byproducts.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107730"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145785368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct contact ultrasound tempering of frozen pork: Effects on physicochemical properties, myofibrillar protein and microstructure","authors":"Xin You ,&nbsp;Liyun Wu ,&nbsp;Feilong Zhang ,&nbsp;Yuze Ou ,&nbsp;Juming Tang ,&nbsp;Hu Shi ,&nbsp;Fanbin Kong ,&nbsp;Feng Li ,&nbsp;Qingqing Zeng ,&nbsp;Yang Jiao","doi":"10.1016/j.ultsonch.2025.107724","DOIUrl":"10.1016/j.ultsonch.2025.107724","url":null,"abstract":"<div><div>Traditional ultrasound-assisted meat tempering usually adopts the water-immersion method, which requires water as a coupling medium and is inconvenient for application in most scenarios. Direct contact ultrasound tempering treatment was proposed to improve the tempering conveniency and retain the freshness of frozen meat products. In this study, the effects of water immersion ultrasound (WUT), direct contact ultrasound with water bag (CUTW), and direct contact ultrasound with ultrasonic couplant bag (CUTC) were compared with traditional air (AT) and water (WT) tempering on the tempering rate and quality of meat. The results demonstrated that, compared with conventional ultrasound methods, direct contact ultrasound tempering (CUTW) achieved comparable efficiency while avoiding the need for water immersion. CUTW produced the highest water-holding capacity (74.64 %) and the lowest cooking loss (25.26 %). It also reduced myofibrillar protein (MP) aggregation and oxidation during tempering, and caused less disruption to MP tertiary structures. Microstructural observations further revealed that muscle fibers in the CUTW-treated samples were denser and exhibited minimal damage. Overall, CUTW provides an effective alternative to immersion-based ultrasound tempering, offering similar or even improved quality outcomes without the inconvenience of water usage, making it more practical for household refrigerator applications.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107724"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145785409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From sonochemical synthesis to predictive modeling: Unraveling the antioxidant properties of La-doped CeO2 nanoparticles","authors":"Jorge L. Mejía-Méndez ,&nbsp;Edwin E. Reza-Zaldívar ,&nbsp;Diego E. Navarro-López ,&nbsp;A. Sanchez-Martinez ,&nbsp;O. Ceballos-Sanchez ,&nbsp;Miguel Badillo ,&nbsp;Angélica Lizeth Sánchez López ,&nbsp;Miguel José Yacaman ,&nbsp;Daniel A. Jacobo-Velázquez ,&nbsp;Edgar R. López-Mena ,&nbsp;Gildardo Sanchez-Ante","doi":"10.1016/j.ultsonch.2025.107704","DOIUrl":"10.1016/j.ultsonch.2025.107704","url":null,"abstract":"<div><div>This study introduces a novel combination of sonochemical synthesis and machine learning (ML) modeling to analyze the effect of Lanthanum (La) doping on the biological properties of cerium oxide (CeO₂) nanoparticles with various La concentrations (0, 1, 5, and 10 at.%). Ultrasonic-assisted synthesis enabled La incorporation into the CeO₂ lattice, resulting changes in crystallinity, lattice parameters, and surface features. Detailed characterization confirmed successful doping and indicated stable nanoparticle suspensions with controlled size ranges. Sonochemical synthesis promoted the oxidation of Ce³⁺ to Ce⁴⁺. Biological testing revealed low cytotoxicity across various cell lines (HepG-2, 3 T3-L1, Caco-2, and U87) and increased antioxidant activity, especially in samples with 5 and 10 at.% La, which demonstrated improved free radical scavenging of DPPH and H₂O₂ radicals. Notably, advanced ML models—including Extremely Randomized Trees, random forest, Gradient Boosting, and LightGBM—enabled the prediction of antioxidant activity based on nanoparticle features, identifying antioxidant method, concentration, and chemical composition as key factors influencing biological effects. This combined experimental and data-driven approach not only clarifies the structure–activity relationships of La-doped CeO₂ nanoparticles but also emphasizes the significant potential of ML in designing and optimizing nanomaterials for biomedical applications. The combination of sonochemical synthesis and ML modeling provides a robust framework for accelerating nanomaterial development by minimizing trial-and-error experiments and providing mechanistic insights into their biological functions.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107704"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotational cavitator: advances and applications in cavitation-enhanced technologies","authors":"Yu-Hang Zhang ,&nbsp;Zhi-Ying Zheng ,&nbsp;David Ezekoye ,&nbsp;Lu Wang ,&nbsp;Li-Ming Yao ,&nbsp;Vladimir A. Kulagin ,&nbsp;Jian Wu","doi":"10.1016/j.ultsonch.2025.107727","DOIUrl":"10.1016/j.ultsonch.2025.107727","url":null,"abstract":"<div><div>Driven by the increasing demand for efficient, energy-saving and sustainable processing technologies, rotational cavitators have shown considerable promise across a range of industrial applications. By inducing intense shear forces and turbulent flow through high-speed rotation in liquid media, rotational cavitation enables strong cavitation effects under controlled conditions, thereby intensifying transport and reaction processes under lower energy input. This review systematically examines the fundamentals, cavitation characteristics and structural evolution of rotational cavitators, with a particular focus on their applications in biofuel production, droplet emulsification, food processing, wastewater treatment and other process intensification. The review comprehensively discusses the benefits of rotational cavitation in multiple application domains, outlines current research progress and emerging trends, and provides theoretical insights and practical guidance for future research and industrial implementation.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107727"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145785369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposome-integrated ultrasound coupling subcritical water extraction for enhanced the efficiency and stability of Phyllanthus emblica polyphenols","authors":"Shuhui Liang ,&nbsp;Xinyi Luo ,&nbsp;Zexin Chen ,&nbsp;Yushi Gong ,&nbsp;Yong Hu ,&nbsp;Fenglin Song ,&nbsp;Yongguang Bi ,&nbsp;Dongmei Li ,&nbsp;Juan Guo","doi":"10.1016/j.ultsonch.2025.107717","DOIUrl":"10.1016/j.ultsonch.2025.107717","url":null,"abstract":"<div><div>Ultrasound coupling subcritical water extraction (USWE) was developed to extract polyphenols from <em>Phyllanthus emblica</em> pomace (PPEPs), and extraction parameters affecting the yield of PPEPs were systematically optimized. USWE was comprehensively evaluated in terms of extraction parameters, yield, antioxidant capacity, major bioactive components, and infrared characteristics of PPEPs, and compared with four other extraction methods. Microstructural changes in the pomace were examined using scanning electron microscopy (SEM) to elucidate the interactions between the extraction process and the plant matrix. Finally, to address the issues of the instability of PPEPs and their low bioavailability, liposomal encapsulation was performed and the physicochemical properties were evaluated. Results demonstrated that the yield of PPEPs from USWE was 1.8-fold and 1.35-fold higher than those from solvent extraction (SE) and subcritical water extraction (SWE), respectively. Furthermore, PPEPs from USWE exhibited the strongest antioxidant activity and higher levels of six major bioactive compounds. SEM analysis revealed a significant increase in porosity and enlarged pores in USWE-treated pomace. Additionally, <em>Phyllanthus emblica</em> polyphenol liposomes (PPEPL) were prepared by thin-film dispersion technique. PPEPL showed a high encapsulation efficiency of 83.07 ± 0.09 % and retained structural integrity after 4 weeks of storage at 4 °C. PPEPL exhibited enhanced antioxidant activity compared to free PPEPs. The IC₅₀ values for scavenging DPPH·, ABTS·⁺, and hydroxyl radicals were 3.2-, 3.3-, and 1.6-fold lower, respectively. In summary, integrating USWE with liposome technology provides an efficient strategy for obtaining stable, high-quality bioactive PPEPs.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107717"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ultrasound pretreatment assisted drying methods on structural and thermal properties of soy protein isolate","authors":"Naveed Mahmood ,&nbsp;Chang Zheng ,&nbsp;Xiaoyan Song ,&nbsp;Yuyang Huang ,&nbsp;Sajad Ali ,&nbsp;Zeeshan Munir ,&nbsp;Farzaneh Khorsandi ,&nbsp;Yang Li ,&nbsp;Fraz Ahmad Khan ,&nbsp;Hafiz Mutther Javed","doi":"10.1016/j.ultsonch.2025.107696","DOIUrl":"10.1016/j.ultsonch.2025.107696","url":null,"abstract":"<div><div>Soy protein isolate, a essential component in various food products, can be greatly impacted by the drying process, influencing its quality and functionality. This study evaluates the effect of ultrasound pretreatments (5, 10, and 15 min at 350 W) and different drying techniques, namely, freeze drying (FD), spray drying (SD) and oven drying (OD) on structural and functional properties of soy protein isolate (SPI) powder. Among all drying conditions, maximum peak temperature T_d (175.31 °C) was achieved with FD after 15 min of ultrasound pretreatment. Sodium dodecyl sulphate–polyacrylamide gel electrophoresis (SDS-PAGE) analysis revealed that ultrasound pretreatment significantly affected protein fragmentation in soy protein isolate (SPI), altering its molecular weight and exhibiting distinct bands compared to control (with distinct bands around 48 kDa and 75 kDa range); demonstrating the most prominent effect of ultrasonic treatment, which further enhanced functional properties. Notably, surface hydrophobicity (H₀) of SPI was significantly higher after ultrasound pretreatments compared to their control samples, suggesting that this application time effectively enhanced the exposure of hydrophobic groups. The relative crystallinity of FD-control, SD-control and OD-control samples were decreased by 6.83 % for FD, 8.14 % for SD and 5.30 % for OD after 15 min of ultrasound pretreated drying, respectively. Ultrasound pretreatment significantly reduced contents of off-flavor compounds, such as 3,5-Octadien-2-one, Decanal, (E)-2-octenal and 2-Pentylfuran in SPI. Moreover, relative content of 3,5-Octadien-2-one in the major volatile off-flavor compound of FD dried SPI reduced from 2.27 % to 1.00 %, 1.05 %, and 0.96 % at 5-, 10-, and 15-minute ultrasound (350 W) application times, respectively. These findings provided valuable insights into selecting appropriate ultrasound pretreated drying techniques to optimize the quality and performance of SPI in various applications.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107696"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between the degree of ultrasound-induced cell disintegration and the extraction efficiency of intracellular compounds from purple sweet potato","authors":"Meng Xu ,&nbsp;Wangting Zhou ,&nbsp;Yilin Li ,&nbsp;Muci Wu ,&nbsp;Rui Zhang ,&nbsp;Jingren He ,&nbsp;Chen Liu","doi":"10.1016/j.ultsonch.2025.107699","DOIUrl":"10.1016/j.ultsonch.2025.107699","url":null,"abstract":"<div><div>Ultrasound (US) is an effective intensified extraction technology for natural plant resources, but detailed microscale investigations into US-induced plant cell disintegration are lacking. This study explored the correlation between US-induced (<em>P</em> = 0–800 W, <em>t</em> = 0–40 min) cell disintegration degree and the extraction efficiency of intracellular components from purple sweet potato, also discussing extraction selectivity and visualizing the cell micro-disintegration process. Cell disintegration degree was estimated via electrical conductivity (cell permeabilization index, <em>Z_i</em>) and fractal dimension analysis of damaged cells (cell wall disintegration index, <em>Z_d</em>). Extraction efficiency was evaluated by using the extraction indexes of carbohydrate (<em>Z_c</em>), protein (<em>Z_p</em>), and total phenolic compound (<em>Z_TPC</em>). Results indicated that US markedly enhanced cell permeabilization and intracellular components release. For example, at the highest intensity (800 W, 40 min), the enhancement in carbohydrate, protein and TPC contents were approximately 2 to 7 folds, compared to untreated sample (0 W, 40 min). Extraction efficiencies depended on the applied <em>P</em> and <em>t</em>, with the extractability order was carbohydrate &gt; protein &gt; TPC at each power. Different non-linear correlations between <em>Z_d</em> with <em>Z_i</em>, <em>Z_p</em>, <em>Z_c</em>, and <em>Z_TPC</em>, reflecting the differences in the release behaviors of these water-soluble components after US treatment. Additionally, US favored carbohydrate extraction over protein, but stronger US intensity resulted in lower extraction selectivity. The visual microscale model showed that increasing <em>P</em> elevated cell surface acoustic pressure, cell stress and volume strain. Cell micro-disintegration process would initiate at the side and end faces, then gradually spread to the edges.</div></div>","PeriodicalId":442,"journal":{"name":"Ultrasonics Sonochemistry","volume":"124 ","pages":"Article 107699"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145613856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}