无创颞叶干扰经颅聚焦超声微泡对小鼠运动皮层的刺激

IF 9.7 1区 化学 Q1 ACOUSTICS
Jie Jin , Xinze Liu , Zhenxiang Ji , Chenxuan Wu , Yuting Han , Quanrong Jing , Jian Zhang , Wei Li , Tianyi Yan , Hui Jing , Dingjie Suo
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引用次数: 0

摘要

经颅聚焦超声(tFUS)已经成为一种创新的脑刺激技术,它独特地集成了三个特点:(a)非侵入性能量传递,(b)亚毫米尺度的空间精度,(c)有效穿透颅骨屏障到达皮层下结构。已有研究表明,微泡可以放大超声的力学效应,利用时间干涉超声激励可以有效降低空化阈值。在本研究中,tFUS应用于正常小鼠和mb注射小鼠的运动皮层。利用肌电图(EMG)记录分析了时间干扰(TI)超声和单频超声刺激对小鼠对侧肢体运动的影响。建立了将Gilmore-Akulichev-Zener (GAZ)模型与非线性脂膜动力学相结合的混合模型,并对微泡(MB)动力学进行了数值模拟,计算了微泡对神经元的分散压力。研究表明,颞叶干涉超声联合MBs可提高运动反应的成功率。可能的机制是时间干涉超声与mb联合产生更高的散射压力。结果表明,时间干扰超声联合MBs可以增强中枢神经系统的神经元活性,使tFUS刺激效率的提高成为一种高度特异性的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The mouse motor cortex stimulation via non-invasive temporal interference transcranial focused ultrasound with microbubbles
Transcranial focused ultrasound (tFUS) has emerged as an innovative brain stimulation technology that uniquely integrates three characteristics: (a) non-invasive energy delivery, (b) submillimeter-scale spatial precision, and (c) effective penetration through cranial barriers to reach subcortical structures. Previous studies have shown that microbubbles (MBs) could amplify the mechanical effects of ultrasound, and the utilization of temporal interference ultrasound excitation effectively lowers cavitation thresholds. In this study, tFUS is applied to the motor cortex of both normal mice and MB-injected mice. Electromyography (EMG) recordings are utilized to analyze the effects of temporal interference (TI) ultrasound and single-frequency ultrasound stimulation on contralateral limb movements in mice. A hybrid model integrating the Gilmore-Akulichev-Zener (GAZ) model with nonlinear lipid membrane dynamics is developed, and numerical simulations of microbubble (MB) dynamics are performed to calculate the scattered pressure exerted by MBs on neurons. The study demonstrated that temporal interference ultrasound combined with MBs could increase the success rate of motor responses. The potential mechanism could be temporal interference ultrasound combined with MBs generate higher scattered pressures. The results demonstrated that temporal interference ultrasound combined with MBs could enhance neuronal activity in the Central Nervous System, enabling a highly specific method to increase the efficiency of tFUS stimulation.
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来源期刊
Ultrasonics Sonochemistry
Ultrasonics Sonochemistry 化学-化学综合
CiteScore
15.80
自引率
11.90%
发文量
361
审稿时长
59 days
期刊介绍: Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.
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