Jie Jin , Xinze Liu , Zhenxiang Ji , Chenxuan Wu , Yuting Han , Quanrong Jing , Jian Zhang , Wei Li , Tianyi Yan , Hui Jing , Dingjie Suo
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引用次数: 0
Abstract
Transcranial focused ultrasound (tFUS) has emerged as an innovative brain stimulation technology that uniquely integrates three characteristics: (a) non-invasive energy delivery, (b) submillimeter-scale spatial precision, and (c) effective penetration through cranial barriers to reach subcortical structures. Previous studies have shown that microbubbles (MBs) could amplify the mechanical effects of ultrasound, and the utilization of temporal interference ultrasound excitation effectively lowers cavitation thresholds. In this study, tFUS is applied to the motor cortex of both normal mice and MB-injected mice. Electromyography (EMG) recordings are utilized to analyze the effects of temporal interference (TI) ultrasound and single-frequency ultrasound stimulation on contralateral limb movements in mice. A hybrid model integrating the Gilmore-Akulichev-Zener (GAZ) model with nonlinear lipid membrane dynamics is developed, and numerical simulations of microbubble (MB) dynamics are performed to calculate the scattered pressure exerted by MBs on neurons. The study demonstrated that temporal interference ultrasound combined with MBs could increase the success rate of motor responses. The potential mechanism could be temporal interference ultrasound combined with MBs generate higher scattered pressures. The results demonstrated that temporal interference ultrasound combined with MBs could enhance neuronal activity in the Central Nervous System, enabling a highly specific method to increase the efficiency of tFUS stimulation.
期刊介绍:
Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels.
Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.