Sensing and Bio-Sensing Research最新文献

Development of a poly (alizarin red S)/EDTA/GCE sensor for rapid and reliable monitoring of methyl parathion pesticide 聚茜素红S /EDTA/GCE传感器快速可靠监测农药中甲基对硫磷的研制

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2025-12-05 DOI: 10.1016/j.sbsr.2025.100938

Andualem Ejigu , Molla Tefera , Adisie Kassa , Atnafu Guadie

{"title":"Development of a poly (alizarin red S)/EDTA/GCE sensor for rapid and reliable monitoring of methyl parathion pesticide","authors":"Andualem Ejigu , Molla Tefera , Adisie Kassa , Atnafu Guadie","doi":"10.1016/j.sbsr.2025.100938","DOIUrl":"10.1016/j.sbsr.2025.100938","url":null,"abstract":"<div><div>Methyl parathion (MP) is a powerful organophosphate insecticide commonly used in agriculture, but it poses serious risks to both human health and environmental safety. This study presents a highly sensitive electrochemical sensor development based on a glassy carbon electrode (GCE) that has been modified in sequence with Ethylenediaminetetraacetic acid (EDTA) and electropolymerized with poly(Alizarin Red S) (poly(ARS)) for detecting MP. The poly(ARS)/EDTA/GCE was characterized with cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The EDTA improves the surface functionality and adhesion, while the redox-active poly(ARS) film aids in electron transfer and offers selective sites for MP interaction. The sensor showed significantly better stability, catalytic performance, and electroactive surface area compared to the unmodified electrode.</div><div>Under optimized pH of 7.0, the sensor reached a limit of detection (LOD) of 0.5527 μM, a limit of quantification (LOQ) of 1.8425 μM, and a linear range from 0.05 to 140 μM, with a sensitivity of 0.1265 μA/μM. It exhibited excellent analytical capabilities, such as repeatability with a relative standard deviation (RSD) of 2.01 %, reproducibility across five independently crafted electrodes with an RSD of 3.13 %, and operational stability over five days with an RSD of 1.76 %. The practical utility of the sensor was validated through MP recovery studies on fresh vegetable samples, which achieved recoveries ranging from 98 % to 113 %.</div><div>In summary, the developed poly(ARS)/EDTA/GCE sensor provides an effective and reliable method for monitoring MP in both environmental and food safety contexts.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100938"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of light incidence angle and polarization on the refractive index sensitivity of tightly-packed ellipsoidal gold nanoparticle layers 光入射角和偏振对致密填充椭圆型金纳米颗粒层折射率灵敏度的影响

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2025-11-27 DOI: 10.1016/j.sbsr.2025.100924

Rebeka Kovács , Lóránt Tibor Csőke , Tomáš Lednický , Attila Bonyár

{"title":"Influence of light incidence angle and polarization on the refractive index sensitivity of tightly-packed ellipsoidal gold nanoparticle layers","authors":"Rebeka Kovács , Lóránt Tibor Csőke , Tomáš Lednický , Attila Bonyár","doi":"10.1016/j.sbsr.2025.100924","DOIUrl":"10.1016/j.sbsr.2025.100924","url":null,"abstract":"<div><div>The effect of excitation angle and polarization on the bulk refractive index sensitivity (<em>RIS</em>) of hexagonally-arranged gold nanoparticles is studied through numerical simulations and experiments. Analytical approximations (based on Rayleigh-Gans theory) and boundary element method (BEM) simulations proved that the <em>RIS</em> of single ellipsoidal particles depends intrinsically on the illumination angle. Compared to normal incidence with linear polarization, the <em>RIS</em> increases by 5–10 % at 70° incidence angle, depending on the particle geometry. Finite element method (FEM) simulations explored near-field coupling in tightly-packed particle assemblies and the effect of a substrate beneath the nanoparticles. The simulations showed that coupling between the particles significantly improves the sensitivity to the incidence angle, resulting in a 17–25 % increase in <em>RIS</em> at 70° illumination compared to normal incidence. Experiments performed on three realized nanoparticle arrangements with varying particle density were carried out in a transmission-based setup with linear, circular polarization, and unpolarized light. Results show significantly increased <em>RIS</em> in the 60°< <span><math><mi>θ</mi></math></span> <75° incidence angle range, namely between a 12–35 % improvement compared to normal incidence, depending on the particle density. These results underline the importance of optimizing the excitation parameters to maximize the sensitivity of nanoplasmonic sensors for localized surface plasmon resonance (LSPR) applications.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100924"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145734169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From muscle potentials to computer interfaces: A multiscale review of electromyography for clinical and computational applications 从肌肉电位到计算机接口：临床和计算应用的肌电图多尺度回顾

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/j.sbsr.2026.100969

Vibha Tiwari , Suyash Khare , Krishna Sharma , Ansh Shrivastava , Rebakah Geddam , Muhammad Awais , Muhammad Ahmed Khan , Hemant Ghayvat

{"title":"From muscle potentials to computer interfaces: A multiscale review of electromyography for clinical and computational applications","authors":"Vibha Tiwari , Suyash Khare , Krishna Sharma , Ansh Shrivastava , Rebakah Geddam , Muhammad Awais , Muhammad Ahmed Khan , Hemant Ghayvat","doi":"10.1016/j.sbsr.2026.100969","DOIUrl":"10.1016/j.sbsr.2026.100969","url":null,"abstract":"<div><div>EMG has been developed as a result of the early physiological experimentation into a primary modality of neuromuscular function characterization, clinical diagno-sis, rehabilitation planning, and human-machine interface. This Review summarizes the history, methodological basis, and computational advances, as well as biomedical applications of EMG, along the entire acquisition-to-interpretation spectrum. The discussion will follow the historical process of increasing the sophistication of early biophysical measurements through surface and intramuscular recording paradigmsthe relevant engineering optimizations, such as optimizing electrode to skin inter-face, signal conditioning, artifact reduction, sampling fidelity, and normalization processes, that cumulatively realize the modern high-quality EMG recording. The review also summarizes the wide range of clinical and biomedical areas influenced by EMG such as the electrophysiological diagnostics, motor control mea-sures, movement-disorder measurements, neuroprosthetic and exoskeletal controls, and the neurorehabilitation based on biofeedback. The advances in analytics are discussed extensively, including handcrafted temporal, spectral and time-frequency representations; hybrid feature-fusion approaches; classical machine-learning classi-fication paradigms and more recent developments in deep learning, transfer learning, through this synthesis, the Review will provide a rigorous and thorough platform of advances that can further advance EMG to highly intelligent, adaptive, and clinically embedded applications in modern biomedicine.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100969"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecularly imprinted polymer-based biosensors for tetracyclines detection: Principles, applications, and emerging trends 四环素检测分子印迹聚合物生物传感器：原理，应用和新兴趋势

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2026-02-17 DOI: 10.1016/j.sbsr.2026.100981

Chau Nguyen Minh Hoang , Son Hai Nguyen , Andrew W. Taylor-Robinson , Cuong Danh Do , Mai Thi Tran

{"title":"Molecularly imprinted polymer-based biosensors for tetracyclines detection: Principles, applications, and emerging trends","authors":"Chau Nguyen Minh Hoang , Son Hai Nguyen , Andrew W. Taylor-Robinson , Cuong Danh Do , Mai Thi Tran","doi":"10.1016/j.sbsr.2026.100981","DOIUrl":"10.1016/j.sbsr.2026.100981","url":null,"abstract":"<div><div>Tetracyclines (TCs) are a group of bacterial protein synthesis inhibitors considered as broad-spectrum antibiotics, which are widely deployed in human and veterinary medicine, aquaculture, and agriculture. Their overuse leaves residues in foods and waters and accelerates the spread of antibiotic-resistant bacteria and resistance genes. As a result, the need for sensitive and selective detection of TCs in complex matrices has become increasingly important. Molecularly imprinted polymer (MIP)-based biosensors have emerged as a promising analytical platform, known for their high specificity, cost-effectiveness, and adaptability to various transduction methods. This review synthesizes recent advancements in MIP-based biosensors for the detection of TC residues, with emphasis on applications in food safety and environmental monitoring. We examine a range of transduction strategies, including electrochemical, fluorescence, and colorimetric methods, evaluating their analytical performance, practicality, and suitability for real-world scenarios. Particular attention is placed on food matrices, such as milk and meat, as well as environmental samples, like river water and livestock waste. Our findings underscore the significant potential of MIP-based biosensors to enhance the monitoring and regulation of TC residues, thereby supporting key initiatives aimed at One Health framework and contributing to several United Nations Sustainable Development Goals (SDGs), including Good Health and Well-Being (SDG 3), Clean Water and Sanitation (SDG 6), Life Below Water (SDG 14), and Life on Land (SDG 15).</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100981"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An easy-to-use nucleic acid-based fluidic platform for the profiling of oral microbiome from swab and mouthwash that consists of functionalized microbeads and a multi-chamber aliquoting structure 一种易于使用的基于核酸的流体平台，用于从拭子和漱口水中分析口腔微生物组，该平台由功能化微珠和多室ali引述结构组成

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2025-11-27 DOI: 10.1016/j.sbsr.2025.100931

Hyejin Lee , Yun Guang Li , Jiatong Kang , Seung Won Shin , Changyoon Baek , Junhong Min

{"title":"An easy-to-use nucleic acid-based fluidic platform for the profiling of oral microbiome from swab and mouthwash that consists of functionalized microbeads and a multi-chamber aliquoting structure","authors":"Hyejin Lee , Yun Guang Li , Jiatong Kang , Seung Won Shin , Changyoon Baek , Junhong Min","doi":"10.1016/j.sbsr.2025.100931","DOIUrl":"10.1016/j.sbsr.2025.100931","url":null,"abstract":"<div><div>The oral microbiome is an important indicator of health status; however, it has the limitation of varying significantly over time and under different life conditions. Therefore, rapid and convenient analysis through automation is required. In this study, we developed an automated oral microbiome analysis platform for the rapid and convenient diagnosis of health using mouthwash as the sample. Functionalized microbeads coated with graphene oxide (GO) were employed to concentrate 5 mL of mouthwash sample into 300 μL within 3 min, achieving an eight-fold concentration. Effective adsorption of bacteria onto the functionalized microbeads was confirmed using scanning electron microscopy. Furthermore, nucleic acids were extracted from bacteria adsorbed on the functionalized microbeads via bead beating (3000 rpm) for 3 min, achieving approximately 100 % yield compared with conventional methods. The extracted nucleic acid solution was then automatically aliquoted into PCR 8-tube strips (2 μL each) with high accuracy (CV% = 2.63 %) using a simple fluidic aliquoting structure that incorporated an access channel and retention area. Oral microbiome profiling at the phylum level was compared between the developed fluidic cartridge method and commercial approaches, including next-generation sequencing (NGS) analysis. The automated platform, which integrates the developed sample pretreatment and aliquoting processes into a fluidic cartridge, successfully analyzed the oral health status of both humans and companion animals within 3 h, demonstrating analytical accuracy equivalent to that of NGS.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100931"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SPR biosensors based on low-dimensional carbon materials for trace urine glucose 基于低维碳材料的微量尿糖SPR生物传感器

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.sbsr.2025.100935

Talia Tene , Jessica Alexandra Marcatoma Tixi , Ximena Alexandra Quintana López , Lala Gahramanli , Rana Khankishiyeva , Cristian Vacacela Gomez

{"title":"SPR biosensors based on low-dimensional carbon materials for trace urine glucose","authors":"Talia Tene , Jessica Alexandra Marcatoma Tixi , Ximena Alexandra Quintana López , Lala Gahramanli , Rana Khankishiyeva , Cristian Vacacela Gomez","doi":"10.1016/j.sbsr.2025.100935","DOIUrl":"10.1016/j.sbsr.2025.100935","url":null,"abstract":"<div><div>Surface plasmon resonance (SPR) biosensors are attractive for non-invasive screening of urine glucose, but their performance depends sensitively on the choice of low-dimensional carbon overlayer and metal stack. Here we numerically compare graphene, semiconducting single-walled carbon nanotubes SWCNT (s-SWCNT), graphene oxide (GO), or reduced graphene oxide (rGO) integrated in a standardized CaF₂/Cu/Si₃N₄/(low-D)/urine stack. Using a transfer-matrix model at 633 nm, with a realistic analyte refractive index change (Δn ≈ 4.6 × 10<sup>−4</sup> RIU) corresponding to 0.015–0.225 g dL<sup>−1</sup> urine glucose, we extract angular sensitivity, linewidth, quality factor, figure of merit, a combined sensitivity factor and theoretical limits of detection. Within an effective-medium description of the carbon films, rGO delivers the highest sensitivity and lowest detection limits but broader resonance dips; GO yields the narrowest dips and the highest precision; graphene and s-SWCNTs offer intermediate responses with stable linewidths and minimal angle drift. We also identify practical thickness windows for each overlayer on Cu that balance sensitivity against spectral sharpness. Compared with prior SPR studies that focus on a single carbon coating or Au-based stacks, this work provides a unified framework and quantitative design rules to select Cu-based low-dimensional overlayers for resolving small, bulk urine-glucose-induced refractive-index changes above the clinical baseline and to guide subsequent experimental implementations.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100935"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145692329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrochemical molecularly imprinted polymer (MIP) sensor for progressive monitoring of antibody production ex vivo 电化学分子印迹聚合物（MIP）传感器用于体外抗体生产的渐进监测

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2026-03-03 DOI: 10.1016/j.sbsr.2026.100991

Kyung Eun You, Joshua Cheng, Jeong Ok Lim, James J. Yoo, Sang Jin Lee, Shay Soker

{"title":"Electrochemical molecularly imprinted polymer (MIP) sensor for progressive monitoring of antibody production ex vivo","authors":"Kyung Eun You, Joshua Cheng, Jeong Ok Lim, James J. Yoo, Sang Jin Lee, Shay Soker","doi":"10.1016/j.sbsr.2026.100991","DOIUrl":"10.1016/j.sbsr.2026.100991","url":null,"abstract":"<div><div>Dynamic monitoring of antibody production is essential for understanding immune responses. Conventional assays like ELISA offer only static measurements and lack temporal representation. To address this limitation, we developed an electrochemical biosensor using molecularly imprinted polymers (MIPs) for rapid, label-free detection of immunoglobulins (IgGs). Our platform enables progressive assessment of IgG production <em>ex vivo</em> through sequential electrochemical measurements. The MIP sensor was fabricated <em>via</em> electropolymerization of <em>o</em>-phenylenediamine and pyrrole in the presence of the Fc fragment of IgG as a template. Selective IgG recognition cavities were formed through combined chemical and electrochemical template removal. An <em>ex vivo</em> platform was established using hybridoma cells encapsulated in hydrogel beads to simulate continuous antibody production over seven days. The sensor detected mouse IgG in the range of 1.56–50 ng/mL with a strong linearity (R<sup>2</sup> = 0.956) and a limit of detection of 1.54 ng/mL, and it also demonstrated the capability to detect IgG in human serum samples. IgG production was progressively monitored in hybridoma culture medium, with temporal trends consistent with ELISA measurements. By Day 7, the ratio of IgG concentration measured by the MIP sensor to that determined by ELISA was approximately 0.95. This study demonstrates the feasibility of the MIP sensor for fast, label-free IgG detection, providing a practical and efficient platform alternative to traditional assays.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100991"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147419799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waveform-aware deep learning for quantitative agglutination on a low-cost lab-in-tubing microfluidic platform 基于低成本管内实验室微流控平台的定量凝集的波形感知深度学习

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2026-02-19 DOI: 10.1016/j.sbsr.2026.100983

Rohith Jayaraman Krishnamurthy, Justin Farrell, Abdul Basit Zia, Abbas S. Milani, Ian G. Foulds

{"title":"Waveform-aware deep learning for quantitative agglutination on a low-cost lab-in-tubing microfluidic platform","authors":"Rohith Jayaraman Krishnamurthy, Justin Farrell, Abdul Basit Zia, Abbas S. Milani, Ian G. Foulds","doi":"10.1016/j.sbsr.2026.100983","DOIUrl":"10.1016/j.sbsr.2026.100983","url":null,"abstract":"<div><h3>Objective</h3><div>To enable quantitative agglutination readout using an ultra-low-cost (parts cost < $40) lab-in-tubing optical platform.</div></div><div><h3>Methods</h3><div>Droplet waveforms were recorded with dual infrared line-break sensors from biotinylated BSA mixed with streptavidin-coated beads at nine levels (0, 0.0128–1000 μg mL-1; <em>N</em> = 223 droplets, <em>N</em> = 211 after QC). We apply waveform-aware preprocessing (i.e., preprocessing operations defined on the full time-series waveform that preserve concentration-dependent morphology rather than reducing the signal to a single scalar) (length normalization, Hampel spike suppression, offset-drift compensation, quality-control filtering, and blank (0 μg mL-1) reference subtraction) and train a one-dimensional convolutional neural network (1D-CNN) to regress log10(concentration). Results: On a stratified 80/20 validation split, the model achieved MAE = 30.49 μg mL-1 with sub-μg absolute errors at trace-to-mid concentrations and larger but scale-appropriate deviations near the apex (∼8 μg mL-1) and in the prozone. Leave-one-concentration-out (LOCO) experiments show that errors increase primarily at omitted calibration anchors, motivating a minimal three-anchor scheme (low, apex, high/prozone) for stable interpolation. Conclusion: Coupling inexpensive optics with waveform-level modeling supports quantitative agglutination estimation across nearly five orders of magnitude (0.0128–1000 μg mL-1). Multi-day, multi-device, and matrix-effect validation remain future work. LOCO is a special case of leave-group-out cross-validation, and we use it here to emulate missing calibration anchors.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100983"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental and finite element analysis of coil position effects in inductive sensors using a design of experiments approach 采用实验设计的方法对电感式传感器线圈位置效应进行了实验和有限元分析

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2026-02-19 DOI: 10.1016/j.sbsr.2026.100985

Morteza Bagheri, Amir Musa Abazari

{"title":"Experimental and finite element analysis of coil position effects in inductive sensors using a design of experiments approach","authors":"Morteza Bagheri, Amir Musa Abazari","doi":"10.1016/j.sbsr.2026.100985","DOIUrl":"10.1016/j.sbsr.2026.100985","url":null,"abstract":"<div><div>Planar coils offer advantages such as a two-dimensional structure and compact design, making them suitable for various applications. They are widely used in position sensing, proximity detection, and non-contact measurement. Planar coils rely on mutual inductance as a key parameter. The mutual inductance changes with the relative displacement between two coils. The mutual inductance variation is the basis of inductive sensors. This study includes both experimental and finite element investigations of the effect of coil displacement on mutual inductance. In the experimental setup, a special fixture was designed to enable the movement of one coil with six degrees of freedom, allowing precise control of both axial and angular displacements. First, the accuracy of the finite element model was validated by comparing its results with those from a reference study, yielding an R<sup>2</sup> score between 0.9377 and 0.9721. The mutual inductance between two coils was evaluated under different conditions using both methods. The Taguchi method was employed to reduce the number while maintaining accuracy. The signal-to-noise ratio analysis showed that minimizing the vertical gap between the coils enhances magnetic coupling, while x-axis rotation has the least effect.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100985"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147421383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-inspired linseed derived carbon quantum dots as a fluorescent probe for the fluorimetric determination of imeglimin in biological fluids and dosage forms 生物启发亚麻籽衍生的碳量子点作为荧光探针，用于荧光测定生物液体和剂型中的伊米霉素

IF 4.9

Sensing and Bio-Sensing Research Pub Date : 2026-02-01 Epub Date: 2025-12-20 DOI: 10.1016/j.sbsr.2025.100946

Aya Barseem , Reem H. Obaydo , Samar H. Elagamy

{"title":"Bio-inspired linseed derived carbon quantum dots as a fluorescent probe for the fluorimetric determination of imeglimin in biological fluids and dosage forms","authors":"Aya Barseem , Reem H. Obaydo , Samar H. Elagamy","doi":"10.1016/j.sbsr.2025.100946","DOIUrl":"10.1016/j.sbsr.2025.100946","url":null,"abstract":"<div><div>This study demonstrates the first fluorimetric method for the determination of Imeglimin IMG, a novel antidiabetic drug. Since IMG lacks native fluorescence, a novel bio-inspired linseed derived carbon quantum dots LIN-CQDs were utilized as a fluorescent probe for its determination. The LIN-CQDs exhibited strong native emission at 470 nm upon excitation at 380 nm. Comprehensive characterization of the synthesized LIN-CQDs was performed using transmission electron microscopy TEM, energy-dispersive X-ray spectroscopy EDX, and X-ray photoelectron spectroscopy XPS, which confirmed the successful formation of nitrogen-doped CQDs. The fluorescence intensity of LIN-CQDs was quenched progressively with increasing concentrations of IMG. The mechanism of quenching was studied and it was found to follow a static quenching process. The quenching response showed excellent linearity over the concentration range of 0.15–3.0 μg/mL. All experimental conditions influencing the quenching process were carefully optimized. The method was validated in compliance with ICH guidelines, demonstrating high accuracy, precision, and specificity. The results of statistical comparison with a previously reported HPLC method confirmed no evident difference between the two approaches for the assay of the drug in its dosage form. Furthermore, the developed method was successfully applied for the assay of IMG in biological fluids including spiked human plasma and urine. The sustainability of the developed method was evaluated using the Analytical Eco-Scale, AGSA, and ComplexMoGAPI, metrics. Owing to its simplicity, sensitivity, and sustainability, the proposed fluorimetric assay provides a green alternative for routine determination of IMG in pharmaceutical analysis.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"51 ","pages":"Article 100946"},"PeriodicalIF":4.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0