Sensing and Bio-Sensing Research最新文献

{"title":"Metal-organic framework-based aptamer sensors for early diagnosis of breast cancer","authors":"Xiaoxia Yao ,&nbsp;Wei Chen ,&nbsp;Chi Zhang ,&nbsp;Weixuan Shao ,&nbsp;Mohammadreza Shokouhimehr ,&nbsp;Can Guo ,&nbsp;Zhengchun Liu","doi":"10.1016/j.sbsr.2025.100855","DOIUrl":"10.1016/j.sbsr.2025.100855","url":null,"abstract":"<div><div>Breast cancer is among the most common neoplasms in women worldwide, and timely detection is important to ensure the greatest chance of survival. Metal-organic frameworks (MOFs) possess specific advantages for application in biosensors because they possess a high specific surface area, tunable pore structure, and excellent biocompatibility. This paper summarizes the research progress of MOF-based aptamer sensors for the early detection of biomarkers of breast cancer, including progress in single-biomarker and multiplex sensing and the use of various detection methods in aptamer-based sensors. Furthermore, it discusses novel component design, optimization of detection methods, and the expansion of clinical applications with MOF-based aptamer sensors. Functionalization and adjustment of MOFs through the introduction of new aptamers and techniques have improved sensor efficiency and provided new paths for early cancer diagnosis. Despite advancements, sensitivity, selectivity, and clinical feasibility concerns are areas that require more efforts.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100855"},"PeriodicalIF":5.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-enhanced terahertz plasmonic biosensor based on MXene-gold nanostructures for tuberculosis detection","authors":"Hussein A. Elsayed ,&nbsp;Jacob Wekalao ,&nbsp;Haifa A. Alqhtani ,&nbsp;May Bin-Jumah ,&nbsp;Mostafa R. Abukhadra ,&nbsp;Stefano Bellucci ,&nbsp;Amuthakkannan Rajakannu ,&nbsp;Ahmed Mehaney","doi":"10.1016/j.sbsr.2025.100852","DOIUrl":"10.1016/j.sbsr.2025.100852","url":null,"abstract":"<div><div>This study presents a terahertz hybrid plasmonic biosensor utilizing MXene‑gold nanocomposites for tuberculosis detection. COMSOL Multiphysics simulations were employed to optimize sensor performance across varying chemical potential, incident angle, and resonator dimensions. The optimized configuration achieved a sensitivity of 1000 GHzRIU⁻¹ and figure of merit of 22.22 RIU⁻¹, with a strong inverse linear relationship between resonance frequency and TB biomarker refractive indices (R² = 0.981). A machine learning framework based on decision tree regression was developed to predict sensor behavior, achieving R² values of 0.96, 0.92, and 0.88 for resonator dimensions, refractive index, and incident angle variations, respectively. The sensor platform offers significant potential for rapid, sensitive TB diagnostics in resource-limited settings.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100852"},"PeriodicalIF":5.4,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring of lipid oxidation using a fluorescent sol-gel functionalized material","authors":"Laura Carballido,&nbsp;Virginie Guerlet,&nbsp;Elias Bou-Maroun,&nbsp;Thomas Karbowiak","doi":"10.1016/j.sbsr.2025.100848","DOIUrl":"10.1016/j.sbsr.2025.100848","url":null,"abstract":"<div><div>The food industry lacks rapid, easy-to-use and non-toxic analytical methods to assess the oxidation level of lipid-rich products. A new fluorescent sol-gel sensing material was developed for the fast and simple monitoring of carbonyls secondary products of lipid oxidation. This paper defines the sensor's range of applicability, specifically examining the impact of the nature and structure of the detected carbonyl compounds, as well as the effects of pH and the nature of the food-simulating medium on its response. The material exhibited high fluorescence intensity, which was quenched upon interaction with carbonyls. The size and hydrophobicity of the analyte (propanal, hexanal, nonanal, 1-penten-3-one and 1-octen-3-one) impacted the kinetics and the percentage of fluorescence quenching as well as the limit of detection and the saturation limit of the sensor. Additionally, the solvent nature had a significant impact on fluorescence: fluorescence intensity was higher in ethanol compared to the more polar ethanol/water (10/90, <em>v</em>/v) mixture used as a food simulant. Finally, the optimal pH range to operate the sensor was determined to be from 7 to 9. This study thus validated the feasibility of using this new sensor for the fast (less than 5 min) and simple (no sample preparation) monitoring of food oxidation level without using any toxic reagent compared to conventional methods. The sensor enables global carbonyl content determination within an operative pH range and a range of detection that would cover the entire shelf-life of lipid-rich food products.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100848"},"PeriodicalIF":5.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyrotaxane-containing hydrogels for label-free detection of C-reactive protein (CRP) via diffraction gratings","authors":"Aitor Cubells-Gómez ,&nbsp;María Isabel Lucío ,&nbsp;Ángel Maquieira ,&nbsp;María-José Bañuls","doi":"10.1016/j.sbsr.2025.100849","DOIUrl":"10.1016/j.sbsr.2025.100849","url":null,"abstract":"<div><div>Hydrogels have been investigated as label-free (LF) holographic biosensors thanks to their ability to change the hydrogel structure when interacting with specific analytes. In this work, we report the development of hydrogel-based holographic diffraction gratings incorporating polyrotaxanes as crosslinkers and phosphorylcholine for the selective and label-free detection of C-reactive protein (CRP), which is a key biomarker for cardiovascular disease, sepsis, and inflammatory disorders. Phosphorylcholine-functionalized monomers were added to the hydrogel composition for specific CRP recognition, while methylated polyrotaxanes (PR-Met) were incorporated to enhance mechanical stability and elasticity. The materials were characterized via scanning electron microscopy (SEM), swelling studies, and mechanical compression tests, demonstrating improved robustness compared to conventional hydrogels. Fluorescence-based assays confirmed the specificity of CRP binding, and diffraction efficiency measurements enabled direct quantification with a limit of detection (LOD) of 0.3 mg L⁻¹. The system was successfully tested using certified human serum samples, achieving recovery rates within the clinically accepted range. This study highlights the potential of polyrotaxane-mediated mechanically enhanced hydrogels as a promising platform for biomolecular sensing, offering improved sensitivity, selectivity, and mechanical resilience for future clinical applications.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100849"},"PeriodicalIF":5.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terahertz ribbon waveguide for sensing electrolyte concentration in phosphate-buffered saline solution","authors":"Ja-Yu Lu ,&nbsp;Pin-Jung Lu ,&nbsp;Borwen You","doi":"10.1016/j.sbsr.2025.100851","DOIUrl":"10.1016/j.sbsr.2025.100851","url":null,"abstract":"<div><div>A subwavelength-thick porous ribbon waveguide (PRW) has been experimentally demonstrated for sensing biological electrolytes in the terahertz (THz) regime. The transmission loss constant of the transverse-magnetic (TM) waveguide mode propagating on a PRW is used as the THz sensing signal and found to be linearly responded to the quantity of electrolytes adsorbed in the PRW core in the measurement of THz time-domain spectroscopy. The propagation-loss change arising from the spatial confinement of the TM waveguide mode can be altered by variations in thickness and refractive-index of the electrolyte-filling PRW core. These findings were verified using the response curve of the THz sensing signal and the one-dimensional modal power distribution in both measurements and simulations. The detection sensitivity of the PRW-based sensing platform was experimentally demonstrated to achieve 0.092 cm⁻¹/(μg/mm²) with an electrolyte-field interaction length of merely 1 cm. The limit of detection for sensing molar concentration changes of electrolytes in phosphate-buffered saline solutions was 23.52 mM within the detectable concentration range of 0.15–1.52 M, corresponding to a molecular density change as low as 18.18 nmol/mm². The sensing performance significantly surpasses that of other THz sensing technologies. The simple and cost-effective PRW-based sensing approach enables efficient detection of trace analytes over a short interaction length, which is the critical feature to be well-suited for various biochemical sensing applications.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100851"},"PeriodicalIF":5.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced THz Optical Sensor for Ethanol and Benzene Detection: A Step towards Safer Industrial and Environmental Monitoring","authors":"Md. Abir Hossain,&nbsp;Md. Abir Hossain,&nbsp;Md. Anowar Kabir,&nbsp;Monir Morshed,&nbsp;Shuvo Sen","doi":"10.1016/j.sbsr.2025.100846","DOIUrl":"10.1016/j.sbsr.2025.100846","url":null,"abstract":"<div><div>Ethanol and Benzene are harmful to climate change, the human body, biodiversity, and long-term ecosystem balance. Normally, ethanol is added to gasoline, which causes climate change, and benzene is used in industries, which can cause cancer. Therefore, it is crucial to accurately identify both ethanol and benzene to ensure people's safety in the environment. This study shows a new and powerful photonic crystal fiber (PCF) sensor that uses terahertz (THz) technology. This sensor is designed to detect ethanol and benzene with high accuracy. The sensor works better because it has a special shape with a six-sided (hexahedron) center and a hexagonal outer cladding layer. According to our experiments, at 2.2 THz, the PCF sensor achieves relative sensitivities of 96.35 % for ethanol and 97.05 % for benzene. Effective Material Loss (EML), Effective Area, and Confinement Loss (CL) for ethanol and benzene are 0.0032 cm⁻¹ and 0.0024 cm⁻¹, 6.88 × 10⁻⁸ m² and 7.79 × 10⁻⁸ m² respectively, and 1.84 × 10⁻⁷ dB/m and 1.89 × 10⁻⁷ dB/m respectively, with operating frequency at 2.2 THz. There are various traditional detection techniques to detect those chemicals, but this proposed optical sensor performs better. So, the proposed PCF sensor demonstrates high sensitivity in simulation and indicates promising potential for future application in industrial safety and environmental monitoring.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100846"},"PeriodicalIF":5.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological characterization of synthesized iron nanoparticles (FeNPs) from Avicennia marina for phenol red removal","authors":"Azhagu Madhavan Sivalingam","doi":"10.1016/j.sbsr.2025.100843","DOIUrl":"10.1016/j.sbsr.2025.100843","url":null,"abstract":"<div><div>In this study, biosynthesized Iron oxide nanoparticles (FeNPs) were green-synthesized using polyphenol-rich <em>Avicennia marina</em> extract. Phytochemical screening of secondary metabolites such as flavonoids, tannins, steroids, saponins, polyphenols and GC–MS identified major twelve bioactive compounds present in (responsible for Fe³⁺ reduction and NP stabilization. The brown FeNPs were characterized by UV–Vis, FTIR, SEM, TEM, XRD, EDX, XPS, and EIS. SEM revealed microscale aggregates containing nanoscale domains (77.78–121.38 nm). XRD confirmed nanocrystalline Fe₃O₄ spinel structure [(220), (311), (400), (511), (440) planes]. EDX showed dominant Fe/O composition. FTIR indicated Fe³⁺-chelating groups (–OH, –S=O). EIS demonstrated enhanced charge transfer (C &lt; sub&gt;dl&lt;/sub≥ 0.146 vs. 0.034 for bare GCE). FeNPs exhibited significant antioxidant activity (DPPH/ABTS), with ethanol extract showing rapid scavenging (866.5 ± 3.5 at 1 min). Total polyphenols reached 212.47 ± 7.07 mg GAE/g extract. Dye adsorption peaked for phenol red (94.9 mg/g at pH 8), following spontaneous/exothermic thermodynamics. The removal efficiency of phenol red (PR) dye by <em>A. marina</em>-FeNPs decreased from 95.6 % to 54.6 % as the initial dye concentration increased from 5 mg/L to 40 mg/L. Temperature studies (25 °C, 35 °C, 45 °C) revealed that increasing temperature significantly decreased PR adsorption efficiency. Similarly, under fixed conditions (5 mg/L dye concentration, 5 g/L adsorbent dosage, pH 6.9), methylene blue (MB) removal efficiency also declined with rising temperature. Thermodynamic parameters (ΔG°, ΔH°, ΔS°) confirmed the adsorption process for both dyes was spontaneous and exothermic. EDX analysis showed the glassware contained 76.56 % iron and 17.09 % oxygen, while the synthesized iron oxide nanoparticles consisted of 46.79 % iron, 36.47 % oxygen, and 15.96 % other elements (including carbon and sulfur). These multifunctional FeNPs show promise for environmental remediation and biomedical applications.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100843"},"PeriodicalIF":5.4,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of a polarization insensitive SPR biosensor for malaria and cancer detection","authors":"Hasan Masud Khan ,&nbsp;Shah Laheen Mashahad ,&nbsp;Md. Asiful Islam ,&nbsp;M. Shah Alam","doi":"10.1016/j.sbsr.2025.100844","DOIUrl":"10.1016/j.sbsr.2025.100844","url":null,"abstract":"<div><div>A polarization-insensitive photonic crystal fiber (PI-PCF) based surface plasmon resonance (SPR) biosensor is designed and analyzed for multianalyte detection. In this work, a simple symmetrical structure is designed using only eight circular-shaped air holes, which makes it not only polarization-insensitive (PI) but also fabrication friendly and reliable. Tantalum pentaoxide (Ta₂O₅) is used with gold (Au) as the plasmonic material to increase SPR excitation, solve adhesion issues, and minimize the reliance on gold. The analytes are placed on the periphery to facilitate the operation of the sensor. The numerical investigations are conducted using the full-vector finite element method (FEM) based COMSOL Multiphysics software to obtain modal solutions (effective refractive index, field distribution) of core and plasmonic modes of the sensor structure. By optimizing its structural parameters, the sensor has demonstrated a maximum wavelength sensitivity (WS) of 65,000 nm/RIU, amplitude sensitivity (AS) of 3709.66 RIU⁻¹, and figure of merit (FOM) of 1160.71 RIU⁻¹, sensor resolution (SR) of 1.53 × 10⁻⁶ RIU, for both x and y-polarizations to detect unknown analyte refractive indices (RIs) from 1.28 to 1.42. Furthermore, the sensor can be used to detect different phases of malaria disease, including ring, schizont and trophozoite phases; it shows the WS of 10,000 nm/RIU for the ring phase and the AS of 2042.77 RIU⁻¹ for the trophozoite phase. Moreover, it can detect six distinct varieties of cancer cells, with WS of 7857.14 nm/RIU for breast (MCF-7) and AS of 5281.01 RIU⁻¹ for cervical (HeLa). The sensor's sensitivity is not significantly affected by air hole dimensions, ensuring high structural tolerance. Its exceptional performance and favorable manufacturing likelihood make it a valuable candidate for biological, biomedical, and biochemical analyte sensing application.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100844"},"PeriodicalIF":5.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary split ring resonator sensors for dielectric characterization of liquids in biosensing applications","authors":"Jonathan Farrugia,&nbsp;Joseph Caruana,&nbsp;Iman Farhat,&nbsp;Julian Bonello,&nbsp;Charles Sammut","doi":"10.1016/j.sbsr.2025.100839","DOIUrl":"10.1016/j.sbsr.2025.100839","url":null,"abstract":"<div><div>This study explores the design, optimization, and experimental validation of complementary split ring resonators (CSRR) for dielectric characterization of liquids, with a focus on biosensing applications. Six CSRR configurations featuring circular geometries with capacitance-enhancing modifications were evaluated. A particle swarm optimization algorithm was employed to maximize sensitivity, quality factor, and resonant peak magnitude. Experimental testing used saline solutions with varying bovine serum albumin concentrations, mimicking the electrical properties of blood. Among the designs, the Meandered Capacitance Single Ring (MC-SR) resonator emerged as the most effective, demonstrating high sensitivity and consistent results. Close alignment between simulations and experiments validated the sensor’s capability to detect subtle dielectric variations within the liquid under test across the 1.5–3 GHz range. Preliminary simulations indicate that the MC-SR CSRR achieves sufficient penetration depth to detect changes beneath skin and subcutaneous fat layers with a combined thickness of 1.5 mm. These findings highlight the potential of CSRR-based sensors for non-invasive biosensing applications, such as monitoring glucose levels and other blood analytes, by effectively addressing sensitivity challenges while only partially improving selectivity. Future efforts will aim to refine on-body sensing applications and enhance robustness in real-world scenarios, with a particular focus on overcoming selectivity limitations.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100839"},"PeriodicalIF":5.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptido-metal framework based electrochemical sensor for the detection of 17- β estradiol: A potential candidate for the diagnosis of ectopic pregnancy","authors":"Giriya Ponnambalam,&nbsp;Stalin Selvaraj","doi":"10.1016/j.sbsr.2025.100845","DOIUrl":"10.1016/j.sbsr.2025.100845","url":null,"abstract":"<div><div>The development and maintenance of female sexual features depend on it. Recent investigations indicate that reduced E2 levels are correlated with markedly elevated probabilities of ectopic pregnancy. Those with E2 levels ≤100 pg/mL were more likely to experience ectopic pregnancy. So, the present work aims to develop an electrochemical sensor for detecting 17 β estradiol as a potential biomarker for identifying ectopic pregnancy. In brief, the E2 sensing were carried out using glutathione copper complex as redox mediator. The glutathione copper complex has been synthesized using simple room temperature one pot procedure and characterized using UV Visible spectroscopy, FTIR for confirming coordination. Then the morphology of glutathione copper complex was analysed using Scanning electron microscopy (SEM). From that the glutathione copper complex proposed the M:L ratio is 1:2. Then, the sensing of E2 were carried out using different electrochemical techniques, including Cyclic voltammetry and Differential Pulse Voltammetry. Our results indicated that the concentrations of E2 increases, peak current gradually decreases with the strong linear negative correlation. The inverse relationship indicates that E2 is being oxidized at the electrode surface with the help of copper complex with glutathione. Based on our findings, the LOD for E2 in PBS and artificial urine sample was found to be 0.125 pg/ml and 4.99 pg/ml respectively. Whereas LOQ for E2 in PBS and artificial urine sample was found to be 5884 pg/ml and 8969 pg/ml respectively. Our developed working electrode does not show any interference with Tyrosine(Y) and Tryptophan(W) and lead for ectopic pregnancy diagnosis.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100845"},"PeriodicalIF":5.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}