Sensing and Bio-Sensing Research最新文献

{"title":"Machine learning-driven terahertz graphene-MXene-gold metasurface biosensor for dual COVID-19 and cervical cancer biomarker detection","authors":"Jacob Wekalao ,&nbsp;Hussein A. Elsayed ,&nbsp;Haifa A. Alqhtani ,&nbsp;Mostafa R. Abukhadra ,&nbsp;Ahmed Mehaney ,&nbsp;Amuthakkannan Rajakannu","doi":"10.1016/j.sbsr.2025.100920","DOIUrl":"10.1016/j.sbsr.2025.100920","url":null,"abstract":"<div><div>This study introduces a terahertz (THz) biosensor designed for rapid and precise detection of COVID-19 viral proteins and cervical cancer biomarkers. The device uses a metasurface structure composed of U-shaped MXene-coated resonators and L-shaped gold-coated elements on a graphene-functionalized circular platform built on a silicon dioxide substrate. It operates across 0.308–0.312 THz for COVID-19 detection and 0.799–0.809 THz for cervical cancer screening, achieving sensitivities of 200 GHz/RIU and 300 GHz/RIU. The corresponding figures of merit range from 2.222 to 2.667 RIU⁻¹ for COVID-19 and 4.848–5.455 RIU⁻¹ for cervical cancer, with quality factors above 14 for the latter. A one-dimensional convolutional neural network model optimized the sensor's response, reaching up to 95 % prediction accuracy and showing a strong linear correlation between resonance frequency and refractive index (R² &gt; 0.99). The architecture can be produced using standard lithography and thin-film deposition methods compatible with existing microelectronic processes. The design allows biofunctionalization with target proteins such as SARS-CoV-2 spike antigens and HPV-related biomarkers. Simulation results align with recent experimental findings in THz biosensing, supporting the feasibility of laboratory testing and clinical application.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100920"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145620293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nanobiosensor integrating FRET and MEF processes for fluorescence-based detection of Chlorpyrifos pesticide through AuNPs@ZIF-8 nanocomposite platform","authors":"Zahra Jomeh Ghasem Abadi ,&nbsp;Salehe Ganjali ,&nbsp;Mehdi Dadmehr ,&nbsp;Ziba Souri Nezami","doi":"10.1016/j.sbsr.2025.100916","DOIUrl":"10.1016/j.sbsr.2025.100916","url":null,"abstract":"<div><div>Pesticide residues in agricultural products are considered as one of the most important health and economic challenges. Chlorpyrifos (CPF), as a widely used organophosphate pesticide in many developing countries, requires precise monitoring due to its adverse effects on human health and the environment. In this study, a novel nanobiosensor was designed and developed for the rapid and sensitive detection of CPF. The system was based on an AuNPs@ZIF-8 nanocomposite as a detection platform which coupled with fluorescence resonance energy transfer (FRET) and metal enhanced fluorescence mechanisms (MEF) processes, in which a CPF-specific aptamer was employed as the recognition element. FRET was occurred after oligonucleotides hybridization and following MEF process was observed after conjugation with nanocomposite. Subsequently, by addition of CPF target the fluorescence intensity of both applied released fluorophores was enhanced. The results demonstrated that the proposed sensor exhibited linear range between of 0.75–5.22 pM with very low detection limit (0.0817 pM). Moreover, performance evaluation in real pistachio samples showed satisfactory recovery (83–95 %) and good reproducibility (RSD: 5.3–6.4 %). Overall, this nanobiosensor can serve as an efficient and reliable tool for the rapid monitoring of chlorpyrifos in agricultural products and for improving quality control in the food industry.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100916"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A robust and highly sensitive electrochemical probe for detection of trace levels of NH3/NH4+ in water based on Berthelot's reaction” [Sensing and Bio-Sensing Research 47 (2025) 100760].","authors":"H. Alwael ,&nbsp;A.S. Alharthi ,&nbsp;A. Alsolami ,&nbsp;M. Oubaha ,&nbsp;B. Duffy ,&nbsp;R.M. Elshafey ,&nbsp;M.S. El-Shahawi","doi":"10.1016/j.sbsr.2025.100905","DOIUrl":"10.1016/j.sbsr.2025.100905","url":null,"abstract":"","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100905"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and application of poly [Cu(Chr)2Cl]Cl/PGE based electrochemical sensor for the determination of Norfloxacin in pharmaceuticals and Milk samples","authors":"Abebaw Shitahun Ayicheh ,&nbsp;Minaleshewa Atlabachew ,&nbsp;Belete Asefa Aragaw ,&nbsp;Amare Benor ,&nbsp;Adane Kassa ,&nbsp;Atakilt Abebe","doi":"10.1016/j.sbsr.2025.100904","DOIUrl":"10.1016/j.sbsr.2025.100904","url":null,"abstract":"<div><div>Norfloxacin (Nor) is a drug belonging to the fluoroquinolones class, commonly used to treat bacterial infections of humans and animals. However, improper use, unmetabolized excretion, and overuse of Nor can lead to bacterial resistance. To mitigate this risk, sensitive, selective, and alternative analytical techniques are required. In this work, a Cu(II)-chrysine complex was synthesized, characterized and applied to modify pencil graphite electrode for electrochemical determination of Nor in pharmaceuticals and milk samples. The tip of the PGE electrode has been modified using the potentiodynamic electropolymerization method and a monomer modifier of [Cu(Chr)₂Cl]Cl using the optimized potential window and film thickness. The modified electrode was characterized using EIS, UV–Vis, CV, digital optical microscopy, and contact angle. Both the developed electrochemical method and UV–Vis spectroscopic method were calibrated and used for the determination of concentration of Nor in two brands of pharmaceuticals, in milk samples, and in the presence of different potential interferences. The percent recoveries of Nor in Nofxin and Gyrablock were in the range of 93.7–99.3 % and 96.6–109.9 %, respectively, and in milk samples, recoveries ranged from 81.80 % to 91.13 %. The developed method exhibited a slope of −0.511 μA/μM, a detection limit (LoD) of 0.096 μM, and a linear dynamic range of 1–100 μM. The developed method was selective towards Nor in the presence of caffeine and paracetamol, making it a promising alternative for the determination of Nor in different matrices.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100904"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A high-performance yet cost-effective Cu/Ag bimetallic SPR biosensor augmented by halide perovskite integration: Unlocking ultra sensitivity and affordable urine-glucose sensing","authors":"M. Mishra ,&nbsp;A. Yadav ,&nbsp;S. Senapati ,&nbsp;S.K. Tripathy","doi":"10.1016/j.sbsr.2025.100884","DOIUrl":"10.1016/j.sbsr.2025.100884","url":null,"abstract":"<div><div>Metal Halide Perovskite (MHP) is introduced into Surface Plasmon Resonance (SPR) biosensor with a bimetallic Cu<img>Ag configuration and urine as the biosample. The Cu/Ag pairing, prior to the application of perovskite, achieves zero reflectivity at 67.8° with a sensitivity of 147°/RIU, exhibiting improvements of 130.8 % over Ag/Cu, 267.5 % over Cu alone, and 390 %, over Ag alone. The study decisively investigates four different halide perovskites—Cesium tin iodide (CsSnI₃), Formamidinium tin iodide (FASnI₃), Potassium tin iodide (KSnI₃), and Cesium lead iodide (CsPbI₃)—integrated into the Cu/Ag structure and optimizes their thicknesses as 8 nm, 10 nm, 12 nm, and 16 nm, respectively. These materials, known for their excellent optical properties and tunability, enhance light-matter interactions, leading to significant gains in SPR sensitivity and detection accuracy. The measured sensitivity values for these perovskites are 460, 406, 352, and 399°/RIU, respectively, with corresponding detection accuracies of 0.238, 0.294, 0.312, and 0.303 RIU⁻¹ with respective quality factors of 109.48, 119, 109.89, and 120. Evidently, CsSnI₃ is found to exhibit the highest sensitivity, supported by fair amount of detection accuracy and quality factor along with an estimated penetration depth of 150 nm, making it the most promising candidate for SPR performance enhancement in this study. Further, a layer of glucose oxidase enzyme is introduced over the halide layers which ensures the high selectivity of the proposed sensor.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100884"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nickel monoligand-MOF modified electrochemical sensor for the detection of neuroblastoma biomarker homovanillic acid","authors":"Shymaa S. Soliman ,&nbsp;Amr M. Mahmoud ,&nbsp;Dina A. El Mously","doi":"10.1016/j.sbsr.2025.100909","DOIUrl":"10.1016/j.sbsr.2025.100909","url":null,"abstract":"<div><h3>Background</h3><div>Early cancer detection is vital for successful clinical outcomes and for advancing public health. It is crucial to detect cancer early for prevention and better treatment. Electrochemical sensors have been developed for disease detection, especially cancer-based on biomarkers, due to their sensitivity, selectivity, affordability, and rapid response. Neuroblastoma is a pediatric cancer originating from neural crest stem cells and is the most prevalent extracranial tumour in infants.</div></div><div><h3>Method</h3><div>The current study discusses the development of an electrochemical sensor for the detection of homovanillic acid (HVA), a tumour biomarker for neuroblastoma and other dopamine-related disorders. The electrochemical oxidation of HVA was investigated utilizing a carbon paste electrode modified with a nickel-based monoligand complex (ML/Ni–MOFs/CPE).</div></div><div><h3>Results</h3><div>This modification significantly improved the electrode's sensitivity and electrocatalytic efficiency. Under optimized conditions, the sensor displayed a linear DPV response within the concentration range of 0.1 μM to 70.0 μM and achieved a low detection limit of 0.08 μM. Morphological and elemental analyses were carried out using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray Diffraction (XRD), and infrared spectroscopy (FT-IR). These characterizations confirmed the uniform dispersion of nickel anchored onto the MOF sheets. Electrochemical performance was further evaluated using electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The ML/Ni–MOFs/CPE electrode exhibited a markedly enhanced HVA oxidation peak current compared with the bare CPE, indicating improved electron transfer kinetics. The electrode demonstrated high reproducibility (RSD &lt; 2 %) and stability, along with good selectivity against common interferents such as creatinine, ascorbic acid, uric acid, and glucose. Application to spiked human urine samples yielded recovery values between 93.25 % and 97.60 %, confirming its analytical accuracy and reliability in biological matrices. The modified electrode retained over 90 % of its initial response after 60 days of storage under ambient conditions, demonstrating outstanding stability and durability.</div></div><div><h3>Significance</h3><div>These findings highlight the potential of the proposed ML/Ni–MOFs/CPE sensor as a rapid, cost-effective, and reliable platform for HVA detection. Its robustness and successful application to urine samples highlight its potential for clinical diagnostics and early neuroblastoma diagnosis, supporting future integration into portable and point-of-care testing systems.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100909"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145516656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimetallic core-shell nano-architecture of Au@Pt as an effective electrochemical mediator for ultrasensitive detection of Listeria monocytogenes in cerebrospinal fluid","authors":"Leila Mehrannia ,&nbsp;Morteza Milani ,&nbsp;Balal Khalilzadeh ,&nbsp;Abolfazl Barzegari ,&nbsp;Solmaz Sadi ,&nbsp;Mohammad Reza Rashidi","doi":"10.1016/j.sbsr.2025.100873","DOIUrl":"10.1016/j.sbsr.2025.100873","url":null,"abstract":"<div><div>Bacterial infections related to <em>Listeria monocytogenes</em> can lead to serious pathological conditions such as meningitis and meningoencephalitis in humans. Therefore, the detection of <em>Listeria</em> particles and byproducts is a very important issue in clinical settings. Nanostructures have been broadly utilized in different areas because of their unique physicochemical properties. Specifically, bimetallic nanostructures have been employed in the development of smart biosensor types. In the study, a simple and efficient platform utilizing bimetallic nanostructures was developed to create a diagnostic system for <em>Listeria monocytogenes</em>. The Au@Pt core-shell structure was synthesized and electrodeposited the glassy carbon electrode (GCE). A 24-mer thiolated single-strand probe, targeting the hly gene, was immobilized on the Au@Pt modified GCE to hybridize with the target sequence. Then, the electrochemical measurement with square wave voltammetry (SWV) technique was done to ensure the hybridization reaction. The biosensor's efficiency was validated using standard addition in real cerebrospinal fluid (CSF) samples, to assess biosensor specificity in the detection of bacterial genomics in biofluids. The obtained results indicate that the designed biosensor was able to detect the target genomic sequences. This platform was capable of detecting targets in 5 to 60 attomolar and was proved as a practical detection limit. It is suggested that the designed platform with high sensitivity and specificity for the detection of target gene sequences in biofluids.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100873"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144989834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manganese-doped g-C3N4 nanozyme-based smartphone platform for rapid L-DOPA detection in clinical samples","authors":"Jianjun Kang ,&nbsp;Xue Lin ,&nbsp;Chen Lin ,&nbsp;Wuyuan Pan ,&nbsp;Jian Wang ,&nbsp;Fang Ke","doi":"10.1016/j.sbsr.2025.100895","DOIUrl":"10.1016/j.sbsr.2025.100895","url":null,"abstract":"<div><div>Levodopa (L-DOPA) is a crucial neurotransmitter utilized in the treatment of neurological disorders, particularly in Parkinson's disease, where its concentration in biological fluids serves as a key diagnostic marker. Despite its significance, current methods for L-DOPA detection often suffer from limitations such as prolonged detection times, low sensitivity and weak anti-interference. This study addresses these challenges by introducing a highly efficient and colorimetric sensor for the rapid detection of L-DOPA, utilizing manganese-doped graphitic carbon nitride (Mn-g-C₃N₄) as a peroxidase-mimetic catalyst. The sensor employs 3,3′,5,5′-tetramethylbenzidine as a substrate and achieves detection within 20 s, with a linear response over the concentration ranges of 1–10 μM and 20–90 μM, and the detection limits were 0.049 μM and 0.51 μM, respectively. The method has good specificity for L-DOPA and has been successfully applied to human serum even in the presence of interference from dopamine and other amino acids. In addition, the sensor exhibits satisfactory performance in smartphone-based L-DOPA detection. The novel sensor platform offers a simple, cost-effective, and scalable solution for real-time L-DOPA monitoring, with significant potential for applications in both clinical and environmental contexts.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100895"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative aptasensor design for chlorpyrifos detection: Combining carbon nanofibers, doped carbon dots, and gold nanoparticles","authors":"Haniyeh Shantiaei,&nbsp;Mahmoud Roushani,&nbsp;Farzaneh Mohammadi","doi":"10.1016/j.sbsr.2025.100922","DOIUrl":"10.1016/j.sbsr.2025.100922","url":null,"abstract":"<div><div>Chlorpyrifos (CPF) is an organophosphate pesticide that is essential for controlling agricultural pests. Nevertheless, residues of this compound, even at low concentrations, raise substantial concerns regarding the environment and human health, including neurotoxic, genotoxic, and reproductive effects. This study aimed to design and fabricate a highly sensitive aptamer-based electrochemical biosensor utilizing P@N, S-CDs/CNFs with gold nanoparticles (AuNPs) for the detection of CPF in fruit and vegetable samples. Initially, nitrogen- and sulfur-co-doped carbon dots (N, S-CDs) were incorporated into polyacrylonitrile (PAN) polymer, resulting in the formation of N, S-CDs/CNFs via electrospinning. Subsequently, P@N, S-CDs/CNFs were produced during the heat treatment process. The hybrid material (P@N, S-CDs/CNFs) was used to modify the surface of the glassy carbon electrode (GCE), followed by the placement of AuNPs on the GCE modified with P@N, S-CDs/CNFs using the drop casting method. The successful synthesis of the nanomaterials was confirmed through XRD, FTIR, and SEM analyses. Under optimal conditions, the aptasensor demonstrated an extensive linear range from 0.1 fg mL⁻¹ to 800 pg mL⁻¹, with a calculated limit of detection as low as 0.033 fg mL⁻¹. The capability of the aptasensor to detect CPF in real samples was assessed by testing extracts of cucumber, tomato, and lettuce.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100922"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual emissive carbon dots as Ratiometric fluorescence sensors: A comprehensive review","authors":"Samar H. Elagamy ,&nbsp;Reem Hasan Obaydo ,&nbsp;Aya Barseem ,&nbsp;Hayam Lotfy","doi":"10.1016/j.sbsr.2025.100930","DOIUrl":"10.1016/j.sbsr.2025.100930","url":null,"abstract":"<div><div>Ratiometric fluorescence sensing offers significant advantages over traditional fluorescence techniques due to its inherent self-referencing nature, enabling robust and accurate measurements. This review focuses on the utilization of Carbon Dots (CDs) as promising platforms for developing ratiometric fluorescence sensors RFS. It outlines the fundamental principles of ratiometric sensing, highlighting its advantages over traditional fluorescence methods. The sensing mechanisms employed in ratiometric sensors are discussed, including intramolecular charge transfer (ICT), fluorescence resonance energy transfer (FRET), chelation-enhanced fluorescence (CHEF), photoinduced electron transfer (PET), excited-state intramolecular proton transfer (ESIPT), aggregation-induced emission (AIE), static quenching effect (SQE), dynamic quenching (DQE) and internal filtration effect (IFE). Furthermore, various methods for constructing CD-based RFS are investigated in this review, including surface functionalization, doping, mixing strategy, hybridization/compositing, and synthesis of intrinsic dual-emissive CDs. In addition, the diverse applications of CD-based RFS in key areas are discussed, such as environmental monitoring, food safety analysis, pharmaceutical analysis, bioanalysis, and bioimaging. Finally, this review highlights the challenges associated with CD-based RFS and outlines potential directions for future research.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"50 ","pages":"Article 100930"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145620289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}