Cost-effective and novel Fe3O4-IL/CPE nanosensor for simultaneous electrochemical detection of theophylline and methyldopa drugs

IF 4.9 Q1 CHEMISTRY, ANALYTICAL

Sensing and Bio-Sensing Research Pub Date : 2025-09-30 DOI:10.1016/j.sbsr.2025.100889

Seyed Karim Hassaninejad-Darzi, Ali Ahangar-Samakosh, Fatemeh Aran-Dinaki, Mohammad Asadollahi-Baboli

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Abstract

Simultaneous determination of methyldopa (MD), and theophylline (THEO) drugs was developed by a modified carbon paste electrode (CPE) with magnetite iron oxide nanostructure and imidazolium ionic liquid (IL). The obtained results displayed that the Fe₃O₄-IL/CPE showed higher oxidation currents versus bare CPE and other modified electrodes. The pH 3.0 for PBS, temperature 34 °C, IL 5.0 %, and Fe₃O₄ 9.0 % in the fabricated sensor were developed as the maximum anodic currents. In the above optimal conditions, the linear responses with the DPV technique were attained in the 2.72–180.32 μM and 7.64–137.93 μM for MD and THEO, respectively. Also, the LOD of 0.90 and 2.52 μM were obtained for MD and THEO, respectively. We, also considered measurement of MD and THEO drugs in human plasma and mixtures of tablets as a real sample and the results show a good recovery percentage.

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同时电化学检测茶碱和甲基多巴药物的新型Fe3O4-IL/CPE纳米传感器

采用磁性氧化铁纳米结构和咪唑离子液体修饰碳糊电极（CPE），建立了同时测定甲基多巴（MD）和茶碱（THEO）药物的方法。结果表明，Fe3O4-IL/CPE比裸CPE和其他修饰电极具有更高的氧化电流。在PBS溶液pH 3.0，温度34℃，IL 5.0 %, Fe3O4 9.0 %的条件下，传感器的最大阳极电流为。在此优化条件下，DPV技术对MD和THEO的线性响应范围分别为2.72 ~ 180.32 μM和7.64 ~ 137.93 μM。MD和THEO的LOD分别为0.90 μM和2.52 μM。我们还考虑了在人血浆和片剂混合物中测定MD和THEO药物作为真实样品，结果显示出良好的回收率。

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来源期刊

Sensing and Bio-Sensing Research Engineering-Electrical and Electronic Engineering

CiteScore

10.70

自引率

3.80%

发文量

审稿时长

87 days

期刊介绍： Sensing and Bio-Sensing Research is an open access journal dedicated to the research, design, development, and application of bio-sensing and sensing technologies. The editors will accept research papers, reviews, field trials, and validation studies that are of significant relevance. These submissions should describe new concepts, enhance understanding of the field, or offer insights into the practical application, manufacturing, and commercialization of bio-sensing and sensing technologies. The journal covers a wide range of topics, including sensing principles and mechanisms, new materials development for transducers and recognition components, fabrication technology, and various types of sensors such as optical, electrochemical, mass-sensitive, gas, biosensors, and more. It also includes environmental, process control, and biomedical applications, signal processing, chemometrics, optoelectronic, mechanical, thermal, and magnetic sensors, as well as interface electronics. Additionally, it covers sensor systems and applications, µTAS (Micro Total Analysis Systems), development of solid-state devices for transducing physical signals, and analytical devices incorporating biological materials.