Sensing and Bio-Sensing Research最新文献

{"title":"Exploring the potential of Triton X-100–assisted thioridazine–rose Bengal adduct as an optical chemosensing probe for detection of thioridazine drug residues in water","authors":"T.N. Abduljabbar,&nbsp;R.Z. Alhasawi,&nbsp;M.S. El-Shahawi","doi":"10.1016/j.sbsr.2026.101056","DOIUrl":"10.1016/j.sbsr.2026.101056","url":null,"abstract":"<div><div>Precise quantification of thioridazine (TDZ) drug residues in water samples is essential due to its widespread use. Thus, this study reports low-cost optical chemosensing probe based on Triton X-100 assisted thioridazine (TDZ) -rose Bengal (RB) associate for TDZ detection in water. The planned probe was based upon liquid–liquid extraction (LLE) of the formed adduct between the ion associate [TDZ⁺·RB⁻] of the protonated TDZH⁺ and RB and Triton X-100 at pH 5 followed by extraction into dichloromethane and spectrophotometric measurement at 580 nm. Under optimized conditions, the developed probe displayed good linear range (LR) of 0.05–4.0 μg mL⁻¹ (1.34 × 10⁻¹–1.07 × 10¹ μ mol L⁻¹), with limits of detection (LOD) and quantification (LOQ) of 1.0 × 10⁻² and 3.33 × 10⁻² μg mL⁻¹, respectively. Notably, the incorporation of TX-100 significantly enhanced the sensitivity of [TDZ⁺·RB⁻] associate through formation of a surfactant-assisted adduct, [(TDZ⁺·RB⁻)·(Triton X-100)ₙ]_org, reducing the LOD and LOQ to 2.0 × 10⁻³ and 6.66 × 10⁻³ μg mL⁻¹, respectively. The extraction constants (D, K_ex, and β), along the stoichiometric, stability, and thermodynamic parameters of the developed associate were systematically evaluated. The low value of ΔH (46.03 J mol⁻¹) revealed the endothermic nature of the ion association reaction and the driving force is not electrostatic interactions but it includes an entropic component and an enthalpic component, stemming from Columbic attraction between opposite charges. The probe displayed good sensitivity and selectivity towards TDZ detection in water. <em>Student's t</em>-test and intra−/inter-day analyses confirmed precision, accuracy, and long-term stability.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101056"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148657334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel paper-based chromogenic chemosensor for the rapid detection of benzodiazepines in beverages","authors":"Jordi Roig-Rubio,&nbsp;Margarita Parra,&nbsp;Salvador Gil,&nbsp;Pau Arroyo,&nbsp;José A. Sáez,&nbsp;Pablo Gaviña","doi":"10.1016/j.sbsr.2026.101062","DOIUrl":"10.1016/j.sbsr.2026.101062","url":null,"abstract":"<div><div>Drug-facilitated sexual assaults represent a critical concern, frequently involving the surreptitious administration of benzodiazepines in beverages. Due to the limitations of traditional instrumental methods for on-site screening, there is a demand for rapid, low-cost, and reliable detection tools. Herein, we report a novel chromogenic chemosensor based on a <em>meso</em>-2,4-dinitrophenyl BODIPY derivative tailored for the specific detection of benzodiazepines. In an alkaline medium, the probe undergoes a reversible dissociation that shifts its color from pale pink to dark yellow. The subsequent addition of a benzodiazepine triggers a distinct naked-eye color transition to purple, achieving a limit of detection of 1.72 μM in solution for diazepam. This probe exhibits very good selectivity, showing no interference from common beverage components or other psychoactive substances used in drug-facilitated sexual assaults such as ketamine, scopolamine, or synthetic cathinones. To facilitate practical in situ application, a user-friendly solid-phase device was developed using cellulosic paper which enables the rapid colorimetric identification of benzodiazepines in real alcoholic and soft drinks. When coupled with smartphone-based image analysis, the device provides a limit of detection of 0.2 mM, which falls within the concentration range in adulterated beverages. These results demonstrate the potential of the proposed system as a sensitive, robust, and accessible tool for the prevention and on-site screening of chemical submission.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101062"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148657340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual CuO.Fe2O3/H-C3N4/GO nanocomposite as an electrochemical sensor for efficient sensing of nitrite","authors":"Unsa Razzaq,&nbsp;Hamna Shafaq,&nbsp;Saima Anjum,&nbsp;Muhammad Imran Khan,&nbsp;Rafael Luque","doi":"10.1016/j.sbsr.2026.101064","DOIUrl":"10.1016/j.sbsr.2026.101064","url":null,"abstract":"<div><div>A novel electrochemical sensor based on a CuO.Fe₂O₃/H-C₃N₄/GO nanocomposite was developed. Characterization of a nanocomposite CuO.Fe₂O₃/H-C₃N₄/GO was done by UV–visible spectroscopy, Fourier transform infrared, X-ray powder diffraction, EIS and DPV and CV methods were employed for electrochemical determination. Results of the voltametric measurements indicated that the oxidation of nitrite was confirmed by the increase in the oxidation peak current attributed to rapid electron transfer. CV was done for different concentrations of nitrite in the range 10–750 μM. This sensor has shown to be highly advanced in the detection of nitrite and had a remarkably low limit (1.26 μM). The results of the study showed that this nanocomposite could be regarded as prospective electric material used for the voltage detection of nitrites in environmental pollution surveillances and their usage in foods and foodstuffs. The increased selectivity and sensitivity of the sensor permit use in many situations for the monitoring of nitrites. The sensor also featured a significant detection range, low detection limit, long-term stability, minimum interference, excellent reproducibility, and consistent repeatability for precise nitrite quantification.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101064"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148737673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Real-time non-contact dielectric sensing of electrolytes and droplets using a wireless LC resonator” [Sensing and Bio-Sensing Research, Volume 53, August 2026, Article 101040]","authors":"Ya-Fu Liou,&nbsp;Hua-En Shih,&nbsp;Yu-Wei Chiang,&nbsp;Sheng-Hsun Huang,&nbsp;Jung-Cheng Liao,&nbsp;Min-Yen Hsieh,&nbsp;Chih-Ting Lin,&nbsp;Sheng-Yu Peng,&nbsp;Chii-Wann Lin","doi":"10.1016/j.sbsr.2026.101052","DOIUrl":"10.1016/j.sbsr.2026.101052","url":null,"abstract":"","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101052"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149004059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-by-cell dielectric and mechanical phenotyping of oocytes","authors":"Osama Alalul,&nbsp;Jintian Liu,&nbsp;Markus Böl,&nbsp;Ala'aldeen Al-Halhouli,&nbsp;Andreas Dietzel","doi":"10.1016/j.sbsr.2026.101079","DOIUrl":"10.1016/j.sbsr.2026.101079","url":null,"abstract":"<div><div>The biomechanics and dielectric properties of mammalian oocytes are key determinants of developmental competence. However, conventional approaches such as optical deformation cytometry are limited by their reliance on high-resolution imaging, requiring complex image analysis techniques and making them unsuitable for large, optically dense cells like oocytes. Here, we present a differential microfluidic impedance cytometry platform that integrates frequency-resolved dielectric profiling with constriction-based deformation analysis. The hybrid glass-SU-8 chip with integrated coplanar electrodes enables high-fidelity measurements up to 30 MHz. Using hydrogel microspheres for calibration, we confirmed that their impedance response was largely frequency-independent. In contrast, porcine oocytes displayed classical β-dispersion, reflecting membrane capacitance and cytoplasmic conductivity, as well as pressure-dependent impedance dynamics indicating viscoelastic resistance. Two-dimensional impedance mapping enabled robust discrimination between hydrogels and oocytes. In addition, fresh oocytes and oocytes recovered from a severe freeze–thaw injury model showed separable electrical and transit-dynamic signatures. Impedance-derived peak-to-valley transit (<em>PVT</em>) analysis notably provided a fully electrical surrogate for deformation dynamics, eliminating the need for video-based tracking. To our knowledge, this is the first application of impedance cytometry to mammalian oocytes and the first demonstration of frequency-resolved differential impedance analysis of mammalian oocytes during pressure-driven constriction transit. Compared with subjective morphological assessment and imaging-dependent deformation analysis, this approach provides objective electrical readouts of dielectric and transit-dynamic phenotypes without labelling. Uniting dielectric profiling with mechanically coupled transit metrics in a single, label-free assay enables discrimination of individual treatment-associated electromechanical phenotypes within oocyte populations. These findings establish the technical feasibility of label-free single-oocyte electromechanical phenotyping.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101079"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148843362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly sensitive CMOS compatible TiN nanorod-assisted plasmonic sensor for temperature and air pressure sensing","authors":"Masrur Ibne Ali,&nbsp;Mustafid Bin Mostafa,&nbsp;Imtiaz Tanweer Rahim,&nbsp;Farhan Ishraque Zahin,&nbsp;A.K.M Rakib,&nbsp;Rakibul Hasan Sagor","doi":"10.1016/j.sbsr.2026.101057","DOIUrl":"10.1016/j.sbsr.2026.101057","url":null,"abstract":"<div><div>This study presents a compact and highly sensitive plasmonic refractive index sensor based on a Titanium Nitride (TiN)–dielectric–TiN configuration. The proposed novel design integrates a straight waveguide with two distinct resonators — one hexagonal and the other square-shaped — forming a composite structure that enables efficient light confinement and enhanced plasmonic coupling. Numerical simulations performed using the Finite Element Method (FEM) confirm that the optimized configuration attains a maximum sensitivity of 2100 nm/RIU and a figure of merit (FOM) of 16.54 RIU⁻¹, demonstrating remarkable sensing capacity. By utilizing TiN as the plasmonic material, the sensor benefits from exceptional thermal stability, resistance to oxidation, mechanical robustness, and full compatibility with CMOS fabrication processes, advantages that conventional noble metals such as gold and silver inherently lack. The combination of structural innovation and material resilience positions the proposed sensor as a cost-effective and durable candidate for future integrated plasmonic and nanoelectronics sensing platforms.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101057"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148657336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical determination of Ticagrelor based on molecularly imprinted poly dopamine and multi-walled carbon nanotubes/ketjen black nanocomposite","authors":"Mahmoud Roushani,&nbsp;Zahra Mirzaei Karazan,&nbsp;Saif Ali Ahmed","doi":"10.1016/j.sbsr.2026.101070","DOIUrl":"10.1016/j.sbsr.2026.101070","url":null,"abstract":"<div><div>Ticagrelor (TIC) is an antiplatelet drug prescribed for patients with stroke and heart attack. In this research, a selective and novel electrochemical sensor was designed based on glassy carbon electrode modified with ketjen black-multi walled carbon nanotubes nanocomposite and molecularly imprinted polymer (MIP/KB-MWCNTs/GCE) to detect TIC. MIP has been used for the first time to assay TIC drug. The proposed sensor is fabricated through electropolymerization of dopamine (DA) as a monomer and TIC as a template on a substrate of KB-MWCNTs nanocomposite. Electrochemical data were taken on the designed sensor via cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The modified electrode obtained low limit of detection (LOD) 0.016 nM, linear range 0.05 to 2300 nM, acceptable selectivity, repeatability, reproducibility, and stability. The applicability of the sensor was investigated in the analysis of real samples such as serum and urine, with a recovery range of 98.4 to 107.0% and a relative standard deviation (RSD) of less than 2.3%. For validation, the results from the real sample were compared with the spectrophotometric reference method.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101070"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148770546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CNT–DNA metamaterial microwave biosensor for dual-parameter label-free DNA sensing: A proof-of-concept study","authors":"A. Cismaru,&nbsp;M. Dragoman,&nbsp;C. Obreja,&nbsp;B. Trica,&nbsp;C. Parvulescu,&nbsp;S. Vulpe,&nbsp;D. Mladenovic,&nbsp;M. Simion,&nbsp;M. Carp,&nbsp;O. Brincoveanu","doi":"10.1016/j.sbsr.2026.101073","DOIUrl":"10.1016/j.sbsr.2026.101073","url":null,"abstract":"<div><div>Label-free nucleic acid sensing with high sensitivity and compatibility with electronic compatibility remains a major challenge in biosensor development. This work presents a proof-of-concept microwave biosensing platform based on a complementary split-ring resonator (CSRR)-integrated metamaterial patch antenna functionalized with a single-walled carbon nanotube–single-stranded DNA (SWCNT–ssDNA) nanocomposite. The study investigates the electromagnetic sensing mechanism by correlating changes in the dielectric properties of the CNT–DNA nanocomposite with resonance-frequency and phase variations. A metamaterial patch antenna incorporating three CSRRs into the radiating patch and exhibiting X- and Ku-band resonances was fabricated, with the Ku-band resonance selected for DNA sensing. SWCNT–ssDNA nanocomposite films with different DNA concentrations were selectively deposited over the high-electric-field CSRR region to maximize electromagnetic interaction. DNA sensing was performed by simultaneously monitoring the resonance frequency and phase of the reflection coefficient, enabling dual-parameter interrogation. Compared with the CNT-coated reference device, the CNT–DNA-functionalized biosensor exhibited maximum frequency and phase shifts of approximately 1 GHz and 126°, respectively. Within the experimentally investigated DNA concentration range of 50–66.7 nM (1.98–2.64 ng/mL), frequency and phase variations of approximately 540 MHz and 33° were observed. A theoretical detection limit of 0.6 pM (24 pg/mL) was estimated from the measured sensitivity and standard deviation of repeated Vector Network Analyzer measurements using the 3σ criterion. TEM and SEM analyses confirmed DNA incorporation within the CNT nanocomposite. These results demonstrate the feasibility of CSRR-confined near-field microwave sensing and provide a foundation for future sequence-specific DNA recognition and hybridization assays.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101073"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148770542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in magnetic nanoparticle-based detection of bacteria: Strategies, challenges, and future perspectives","authors":"Rajkumar Divya,&nbsp;Pranay Tyagi,&nbsp;Ishita Ghosh,&nbsp;Arputharaj Joseph Nathanael","doi":"10.1016/j.sbsr.2026.101081","DOIUrl":"10.1016/j.sbsr.2026.101081","url":null,"abstract":"<div><div>Bacterial diseases and their different forms of severity affect millions of people worldwide at any given time. Conventional bacterial detection methods, though widely used, are limited by long processing times, reliance on skilled personnel, sophisticated equipment, and poor suitability for point-of-care use. Thus, there is a constant need for advanced bacterial detection methods and techniques that will produce rapid results so that early diagnosis of diseases can be done. It will also help in ensuring the safety of food and environmental samples, which are the most common sources of bacterial diseases. This is where magnetic nanoparticles (MNPs) prove to be valuable and effective. Their properties of superparamagnetism, high surface-to-volume ratio, biocompatibility and the convenience of functionalization make MNPs a reliable and advanced tool for rapid bacterial detection. This review provides an overview of the current bacterial detection mechanisms using MNPs and how different strategies for their compositional or surface modifications can improve sensitivity and optimize the rate of limit-of-detection (LOD). Real-time application of MNPs for bacterial detection in samples such as food, environmental sources, urine, blood, and other body fluids or cells has also been studied in this review. It also discusses the recent developments incorporating MNPs in other detection techniques, such as CRISPR, and explores how artificial intelligence (AI) can be used to build smart detection systems.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101081"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148958735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A disposable label-free MXene/graphene-based aptasensor for the electrochemical detection of Cystatin C in human sweat","authors":"Giulia Matteoli,&nbsp;Elena De Gregorio,&nbsp;Lorena Tedeschi,&nbsp;Nicola Calisi,&nbsp;Matteo Mannini,&nbsp;Claudio Evangelisti,&nbsp;Stefano Legnaioli,&nbsp;Beatrice Campanella,&nbsp;Tommaso Lomonaco,&nbsp;Silvia Ghimenti,&nbsp;Aurora Mustile,&nbsp;Denise Biagini,&nbsp;Antonio Vilasi,&nbsp;Pietro Salvo","doi":"10.1016/j.sbsr.2026.101068","DOIUrl":"10.1016/j.sbsr.2026.101068","url":null,"abstract":"<div><div>Cystatin C is a key biomarker for assessing kidney disease since its level increases in response to renal dysfunction. Current techniques detect Cystatin C in plasma, saliva, and urine, but the detection in sweat has not been explored. This paper describes a disposable label-free 2D nanomaterial-based aptasensor for assessing Cystatin C levels in human sweat. The aptasensor consisted of an aptamer immobilized on a Ti₃C₂–rGO layer for the non-invasive label-free electrochemical detection of Cystatin C. Electrochemical Impedance Spectroscopy showed that the aptasensor had a limit of detection of about 1 ng/mL (linear range 2–25 ng/mL) and can thus possibly help better discriminating among the five stages of kidney disease when combined with the measurement of creatinine. Potential sweat-specific interferents such as NaCl, urea, lactate, glucose and ascorbic acid did not affect the aptasensor response. This aptasensor proved the detection of Cystatin C in human sweat and may offer a promising alternative for the real-time monitoring of renal disease.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"53 ","pages":"Article 101068"},"PeriodicalIF":4.7,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148737677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}