Sensing and Bio-Sensing Research最新文献_第3页

A perspective on the selection and design of antimicrobial peptides for bacteria detection 细菌检测用抗菌肽的选择与设计

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-18 DOI: 10.1016/j.sbsr.2025.100794

Miral O. Sabry , Dan Li , Leon C.Z. Chan

{"title":"A perspective on the selection and design of antimicrobial peptides for bacteria detection","authors":"Miral O. Sabry , Dan Li , Leon C.Z. Chan","doi":"10.1016/j.sbsr.2025.100794","DOIUrl":"10.1016/j.sbsr.2025.100794","url":null,"abstract":"<div><div>Antimicrobial peptides (AMPs) are versatile biomolecules with unique properties, including specificity, stability, and ease of synthesis, making them promising candidates for bacteria detection in biosensors. This review explores the potential of AMPs as biorecognition elements, emphasizing their structural properties, interaction mechanisms with bacterial membranes, and their application in biosensing. AMPs offer advantages such as being less prone to bacterial resistance mechanisms and compatibility with various biosensor platforms, including optical and electrochemical sensors. Recent advancements in AMP design strategies, such as in-silico modeling and structural tailoring, in addition to immobilization techniques, are discussed, highlighting their role in enhancing AMP properties. Challenges and current research gaps affecting AMP efficacy in biosensors are critically examined and possible solutions are suggested and discussed. Future directions include the development of multiplexed AMP-based biosensors and integration into smart food packaging for real-time pathogen monitoring. By addressing current research gaps, AMPs could revolutionize bacterial detection methodologies across multiple fields, including medicine, food safety, and environmental monitoring.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"48 ","pages":"Article 100794"},"PeriodicalIF":5.4,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green voltammetric strategy for sensitive determination of paracetamol in pharmaceuticals and serum using alizarin red S-modified glassy carbon electrodes 用茜素红s修饰玻碳电极测定药物和血清中扑热息痛的绿色伏安策略

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-17 DOI: 10.1016/j.sbsr.2025.100792

Wudneh Girum, Adane Kassa

{"title":"Green voltammetric strategy for sensitive determination of paracetamol in pharmaceuticals and serum using alizarin red S-modified glassy carbon electrodes","authors":"Wudneh Girum, Adane Kassa","doi":"10.1016/j.sbsr.2025.100792","DOIUrl":"10.1016/j.sbsr.2025.100792","url":null,"abstract":"<div><div>This study introduces a highly sensitive electrochemical method for detecting paracetamol (PCT) in pharmaceutical tablets and human serum samples, utilizing a glassy carbon electrode modified with alizarin red S (poly (ARS)/GCE). PCT is one of the most widely used analgesic and antipyretic drugs; however, its overdose or prolonged use can lead to severe liver and kidney damage. Therefore, the development of sensitive and reliable methods for monitoring PCT levels in pharmaceutical formulations and biological fluids is crucial for ensuring drug safety and effective therapeutic monitoring. Characterization of the electrode confirmed that the surface modification with a conductive and electroactive polymer film (poly(ARS)) significantly enhanced the effective electrode surface area and reduced charge transfer resistance. Compared to the unmodified electrode, the modified electrode exhibited a well-resolved, irreversible redox peak at a significantly lower potential with a sixfold increase in current, highlighting the catalytic efficiency of the modifier toward PCT. The electrochemical behavior of PCT was analyzed via cyclic voltammetry and square wave voltammetry, revealing significantly enhanced sensitivity and selectivity due to the conductive polymer coating. Under optimized electrode condition square wave voltammetric current response of poly(ARS)/GCE showed linear dependence on concentration of 0.01–250.0 μM and an ultralow detection limit of 1.0 nM in phosphate buffer solution (pH 7.0). Analytical application on real samples confirmed the method's accuracy, achieving recovery rates of 98.8–100.3 % for pharmaceutical tablets and human blood serum, even in the presence of potential interferents. The developed method provides a cost-effective and robust alternative for PCT quantification, with superior performance compared to previously report electrochemical approaches.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"48 ","pages":"Article 100792"},"PeriodicalIF":5.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telluride quantum dot-amplified immunosensor for interferon gamma – A TB antigen test biomarker 干扰素γ - A结核抗原检测生物标志物的碲化物量子点扩增免疫传感器

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-15 DOI: 10.1016/j.sbsr.2025.100788

Sixolile Mini , Kaylin Cleo Januarie , Marlon Oranzie , Candice Cupido , Kefilwe Vanessa Mokwebo , Usisipho Feleni , Emmanuel Iwuoha

{"title":"Telluride quantum dot-amplified immunosensor for interferon gamma – A TB antigen test biomarker","authors":"Sixolile Mini , Kaylin Cleo Januarie , Marlon Oranzie , Candice Cupido , Kefilwe Vanessa Mokwebo , Usisipho Feleni , Emmanuel Iwuoha","doi":"10.1016/j.sbsr.2025.100788","DOIUrl":"10.1016/j.sbsr.2025.100788","url":null,"abstract":"<div><div>Interferon-gamma (IFN-γ) is a cytokine (i.e. a microprotein involved in cell signaling and immunomodulation) which is known to be expressed in response to <em>Mycobacterium tuberculosis</em> (Mtb) infections. For this reason, IFN-γ has gained prominence as a diagnostic biomarker for TB antigen tests, such as Interferon-Gamma Release Assays (IGRAs). Recent research efforts have focused on improving the sensitivity of TB tests based on IFN-γ. In this study, a new and sensitive chalcogenide-based electrochemical IFN-γ immunosensor was developed. The chalcogenide is a 9.30 nm average diameter bimetallic copper zinc telluride (CuZnTe) quantum dot (QD) particles, which were stabilised by sequential triple-capping with thioglycolic acid (TGA), (3-mercaptopropyl)trimethoxysilane (MPS) and tetraethylorthosilicate (TEOS) (i.e. CuZnTe-TGA-MPS-TEOS QD). The morphologies of the quantum dots were determined by X-ray transmission electron microscopy (TEM) and small angle X-ray scattering spectroscopy (SAXS); while their structural characteristics were ascertained with Raman and X-ray diffraction (XRD) spectroscopic analyses. A gold disk electrode (AuE) surface was functionalized with CuZnTe-TGA-MPS-TEOS QD, anti-interferon-gamma antibody (Anti) and bovine serum albumin (BSA) to create a BSA/Anti/CuZnTe-TGA-MPS-TEOS QD/AuE amperometric immunosensor bioelectrode. The immunosensor exhibited a linear detection range (LDR) value of 2–20 pg/mL IFN-γ, a limit of detection (LOD) value of 0.82 pg/mL IFN-γ and was highly sensitive in human serum samples with recovery rates of 97–99 %.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"48 ","pages":"Article 100788"},"PeriodicalIF":5.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive resolution in speckle displacement measurement using optimized grid-based phase correlation and statistical refinement 基于优化网格相位相关和统计细化的散斑位移测量自适应分辨率

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-15 DOI: 10.1016/j.sbsr.2025.100790

Hamed Sabahno , Satyam Paul , Davood Khodadad

{"title":"Adaptive resolution in speckle displacement measurement using optimized grid-based phase correlation and statistical refinement","authors":"Hamed Sabahno , Satyam Paul , Davood Khodadad","doi":"10.1016/j.sbsr.2025.100790","DOIUrl":"10.1016/j.sbsr.2025.100790","url":null,"abstract":"<div><div>Speckle metrology is a powerful optical sensing tool for non-destructive testing (NDT) and advanced surface characterization, enabling ultra-precise measurements of surface deformations and displacements. These capabilities are critical for material analysis and surface assessment in sensing-driven applications. However, traditional correlation methods often struggle to balance resolution and robustness, particularly when simultaneously measuring both small- and large-scale deformations in noisy, high-frequency data environments. In this paper, we present an adaptive resolution approach for speckle displacement measurement that combines grid-based phase correlation with statistical refinement for enhanced accuracy and resolution.</div><div>Unlike traditional phase correlation techniques that rely on global correlation, our method introduces a flexible grid-based framework with localized correlation and dynamic overlap adjustments. To improve measurement performance, we developed an optimization technique that uses the median absolute deviation of residuals between reference and deformed images, enabling the algorithm to automatically adapt grid sizes based on local deformation characteristics. This allows it to handle both small- and large-scale deformations simultaneously and effectively. The approach resulted in a relative error reduction of up to 14 % compared to the best of the results obtained using a manually fixed grid size.</div><div>The proposed sensing methodology is validated through a series of numerical simulations and experimental studies, including controlled deformations with a micrometer translation stage and random speckle displacements on water-sprayed surfaces. Results demonstrate that our method can accurately detect both known and unknown deformations with high accuracy and precision, outperforming traditional techniques in terms of adaptability and robustness, particularly for surface deformation analysis.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"48 ","pages":"Article 100790"},"PeriodicalIF":5.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermal reduction synthesis approach of reduced graphene oxide for the preparation of a label-free and prompt immuno sensing of Salmonella enterica via electrochemical techniques 还原氧化石墨烯的热还原合成方法，用于制备通过电化学技术对肠炎沙门氏菌进行无标记和快速免疫传感的方法

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-12 DOI: 10.1016/j.sbsr.2025.100789

Nahid Rehman , Ashutosh Pandey , Anjana Pandey

引用次数: 0

Ultrasensitive label-free ratiometric colorimetric sensor for free chlorine detection in tap water based on a novel brilliant blue-Au NCs 基于新型亮蓝-金 NCs 的超灵敏无标记比率比色传感器，用于检测自来水中的游离氯

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-08 DOI: 10.1016/j.sbsr.2025.100785

Dongning Li , Yanli Liu , Xin Xu , Wenfang Sun , Haiping Ni , Xiangping Liu

引用次数: 0

Multiphysical model of CMUT array based on modal decomposition and the Rayleigh integral 基于模态分解和瑞利积分的CMUT阵列多物理模型

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-08 DOI: 10.1016/j.sbsr.2025.100784

A.E. Biriukov, A.M. Korsunsky

{"title":"Multiphysical model of CMUT array based on modal decomposition and the Rayleigh integral","authors":"A.E. Biriukov, A.M. Korsunsky","doi":"10.1016/j.sbsr.2025.100784","DOIUrl":"10.1016/j.sbsr.2025.100784","url":null,"abstract":"<div><div>There is a high number of modeling techniques for calculation of characteristics of capacitive micromachined ultrasound transducers. Very few of them are capable of calculation of the acoustic field, especially when the number of cells in the array is huge. Implementation of an approach based on superposition of modes and the Rayleigh integral is suggested. A computer model, utilizing this approach, also includes other methods for calculation of related parameters. A mass-spring-damper model is used to determine the lumped parameters and influence of the softening effect. Solution to a thin plate equation gives eigenfrequencies and eigenmodes used to find the membrane's response to an arbitrary excitation. For accurate evaluation of an acoustic field, the model discretizes normal velocity on a surface of the array. The array supports simple generation with individual phase shifts between the cells. The model is parametrized and adapted for an interface with user. An example object with specified physical and geometrical parameters is given. The key mechanical and acoustical characteristics are presented for the provided example object with a detailed description for their calculation. The model is verified by comparison to FEM within these characteristics. An acoustical study is conducted for an array with 4 example cells for two cases of phase shifts. The effectiveness of the proposed method in comparison with FEA is provided: in terms of time for following studies: lumped parameters, eigenvalues, frequency response (mechanical and acoustical) and radiation pattern; in terms of accuracy for a parametric lumped parameters study.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"48 ","pages":"Article 100784"},"PeriodicalIF":5.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and electrocatalytic performance of CoW11CpFe@Cu-BTC/MWCNTs-COOH modified glassy carbon electrode for simultaneous detection of dopamine and uric acid CoW11CpFe@Cu-BTC/MWCNTs-COOH修饰玻碳电极同时检测多巴胺和尿酸的制备及其电催化性能

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-08 DOI: 10.1016/j.sbsr.2025.100786

Somayeh Kochebaghi , Somayeh Dianat

{"title":"Fabrication and electrocatalytic performance of CoW11CpFe@Cu-BTC/MWCNTs-COOH modified glassy carbon electrode for simultaneous detection of dopamine and uric acid","authors":"Somayeh Kochebaghi , Somayeh Dianat","doi":"10.1016/j.sbsr.2025.100786","DOIUrl":"10.1016/j.sbsr.2025.100786","url":null,"abstract":"<div><div>Simultaneous detection of dopamine (DA) and uric acid (UA) is clinically important but challenging due to their similar properties, which often lead to poor sensitivity and specificity in traditional diagnostic methods.</div><div>To address this, the study presents a novel hybrid nanocomposite-POM@MOF/MWCNTs-COOH-engineered for the selective and sensitive detection of both biomarkers. The material was thoroughly characterized using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction analysis (XRD), transmission electron microscopy (TEM), inductively coupled plasma-optical emission spectrometry (ICP-OES), Brunauer-Emmett-Teller (BET) analysis, x-ray photoelectron spectroscopy (XPS), and field-emission scanning electron microscopy (FE-SEM). Electrochemical profiling was conducted using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and amperometry. Under optimal conditions, the sensor demonstrated linear detection ranges of 5–100 μM and 100–550 μM for DA, with a limit of detection (LOD) of 0.16 μM, and 200–950 μM and 950–4450 μM for UA, with an LOD of 0.82 μM, as determined by DPV. These findings highlight the potential of our novel hybrid nanocomposite as a promising tool for clinical diagnostics. This innovative hybrid nanocomposite offers significant advantages over existing sensing platforms for DA and UA detection. Its unique combination of high acidity, oxygen-rich surface, and robust redox capabilities enables simultaneous detection of both analytes with enhanced sensitivity and specificity. The sensor's exceptional electrocatalytic performance positions it as a promising tool for clinical diagnostics, potentially improving healthcare outcomes through accurate biomarker detection at clinically relevant concentrations.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"48 ","pages":"Article 100786"},"PeriodicalIF":5.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143833783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and fabrication of multiplex microfluidic LAMP PCR for simultaneous detection of opportunistic protozoa 同时检测机会性原生动物的多重微流控LAMP PCR设计与制备

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-08 DOI: 10.1016/j.sbsr.2025.100787

Fatemeh Mahdavi , Maryam Niyyati , Amir Shamloo , Rasool Dezhkam , Seyed Mohammadali Hoseinian , Seyyed Javad Seyyedtabaei , Hamed Mirjalali

{"title":"Design and fabrication of multiplex microfluidic LAMP PCR for simultaneous detection of opportunistic protozoa","authors":"Fatemeh Mahdavi , Maryam Niyyati , Amir Shamloo , Rasool Dezhkam , Seyed Mohammadali Hoseinian , Seyyed Javad Seyyedtabaei , Hamed Mirjalali","doi":"10.1016/j.sbsr.2025.100787","DOIUrl":"10.1016/j.sbsr.2025.100787","url":null,"abstract":"<div><div>Intestinal parasites are a health problem in many regions, especially in developing countries. <em>Giardia lamblia</em>, <em>Cryptosporidium</em> spp., and <em>Enterocytozoon bieneusi</em> are of great diagnostic importance, particularly in immunocompromised patients and children. This study aimed to develop a multiplex microfluidic LAMP (MμLAMP) PCR for rapid detection of three protozoa. The LAMP primers were designed for the parasites. The microfluidic disk with different compartments was designed using AutoCAD software and fabricated by laser beam. After DNA extraction, the amplifications were performed for all positive samples using MμLAMP PCR. Sensitivity and specificity of tests were calculated and the results were compared to the real-time PCR. The LAMP analysis revealed that 29/30 (96.7 %), 12/19 (63.2 %), and 25/30 (83.3 %) samples were positive for <em>G. lamblia</em>, <em>Cryptosporidium</em> spp., and <em>E. bieneusi</em>, respectively. The specificity results of the LAMP method were high and the sensitivity test results indicated that the LAMP method has the ability to detect 180 ag/μL of <em>G. lamblia</em> DNA, 2.5 fg/μL of <em>Cryptosporidium</em> spp. DNA, and 34 ag/μL of <em>E. bieneusi</em> DNA. The multiplex accuracy results of microfluidic disk showed that none of two-parasite DNA mixes with their non-specific primers cause false positive results. The present study simultaneously detects <em>G. lamblia</em>, <em>Cryptosporidium</em> spp., and <em>E. bieneusi</em>. The current results indicate that the MμLAMP PCR method is a rapid, sensitive, and highly specific method for simultaneous detection of <em>G. lamblia</em>, <em>Cryptosporidium</em> spp., and <em>E. bieneusi</em> in clinical studies, making it a suitable tool for screening and point of care (PoC) testing.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"48 ","pages":"Article 100787"},"PeriodicalIF":5.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of eco-friendly and cost-effective electrochemical sensor for the simultaneous detection of 4-aminophenol and paracetamol in water 同时检测水中4-氨基酚和扑热息痛的环保、高性价比电化学传感器的研制

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2025-04-02 DOI: 10.1016/j.sbsr.2025.100782

Antía Fdez-Sanromán , Najib Ben Messaoud , Marta Pazos , Emilio Rosales , Raquel Barbosa Queirós

{"title":"Development of eco-friendly and cost-effective electrochemical sensor for the simultaneous detection of 4-aminophenol and paracetamol in water","authors":"Antía Fdez-Sanromán , Najib Ben Messaoud , Marta Pazos , Emilio Rosales , Raquel Barbosa Queirós","doi":"10.1016/j.sbsr.2025.100782","DOIUrl":"10.1016/j.sbsr.2025.100782","url":null,"abstract":"<div><div>Pharmaceutical waste contamination is an increasing environmental concern due to its persistence and potential adverse impact on aquatic ecosystems. Among these contaminants, paracetamol (PA) and 4-aminophenol (4-AP) are prevalent in urban wastewater due to their widespread use. Accurate detection of these compounds is essential for environmental risk assessment and mitigation strategies. In this study, an electrochemical sensor based on carbon screen-printed electrodes (C-SPEs) modified with functionalized carbon nanofibers (CNF-COOH) was developed for the simultaneous detection of PA and 4-AP. The electrochemical performance of commercially available gold and carbon-based SPEs was evaluated, demonstrating superior sensitivity for PA and 4-AP with C-SPEs. The incorporation of CNF-COOH improved electron transfer and increased surface area, enhancing both sensitivity and selectivity by facilitating stronger interactions with the target analytes. The novel C-SPE/CNF-COOH sensor achieved detection limits of 0.002 mM for PA and 0.007 mM for 4-AP. It was successfully tested in real freshwater samples, demonstrating high accuracy even in complex matrices. This innovative methodology provides a rapid, cost-effective, and portable analytical tool for routine monitoring of pharmaceutical contaminants, enabling more accurate environmental risk assessments and supporting the implementation of more efficient management strategies.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"48 ","pages":"Article 100782"},"PeriodicalIF":5.4,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0