Sensing and Bio-Sensing Research最新文献_第3页

Universal strategy for rapid design and analysis of gas detection peptide chips with positional preference 快速设计和分析具有位置偏好的气体检测肽芯片的通用策略

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-09-19 DOI: 10.1016/j.sbsr.2024.100697

Honghao Zhang , Xi Zhang , Yingjun Si , Hui Li , Jiyang Han , Chuan Yang , Hui Yang

{"title":"Universal strategy for rapid design and analysis of gas detection peptide chips with positional preference","authors":"Honghao Zhang , Xi Zhang , Yingjun Si , Hui Li , Jiyang Han , Chuan Yang , Hui Yang","doi":"10.1016/j.sbsr.2024.100697","DOIUrl":"10.1016/j.sbsr.2024.100697","url":null,"abstract":"<div><p>The design and analysis of gas detection chips directly affect their detection efficiency and applicability. Detection devices are currently restricted by detection principles, facing drawbacks like intricate structural design, limited applicability, and low detection efficiency. We have designed a complete set of design and analysis scheme for a peptide gas detection chip. First, we selected specific and high-affinity peptide combinations from existing peptide-gas affinity datasets. Then, the peptide chip's arrangement was grouped according to the variations in peptides' affinity towards different gases. Peptides were arranged based on their affinity levels within each group, striking a balance between discrimination and flexibility in the design of the chip. Finally, we evaluated the analysis methods by generating simulated data based on a reference affinity matrix constructed from actual data. Due to the preprocessing role of chip design on affinity data, all methods can effectively accomplish gas classification. In gas concentration prediction tasks, our method reduced mean square error to 0.41, significantly outperforming other methods. This gas detection scheme shortens the development cycle of chip design and analysis methods, fully utilizing the specificity of peptides, enhancing gas analysis effectiveness, and demonstrating the agile development of gas detection chips.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"46 ","pages":"Article 100697"},"PeriodicalIF":5.4,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000795/pdfft?md5=6be00bfaca83ebb566970c279bc5c166&pid=1-s2.0-S2214180424000795-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sediment microbial fuel cells capable of powering outdoor environmental monitoring sensors 能够为室外环境监测传感器供电的沉积物微生物燃料电池

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-09-17 DOI: 10.1016/j.sbsr.2024.100695

Yolina Hubenova , Ivo Bardarov , Eleonora Hubenova , Evelina Slavcheva

{"title":"Sediment microbial fuel cells capable of powering outdoor environmental monitoring sensors","authors":"Yolina Hubenova , Ivo Bardarov , Eleonora Hubenova , Evelina Slavcheva","doi":"10.1016/j.sbsr.2024.100695","DOIUrl":"10.1016/j.sbsr.2024.100695","url":null,"abstract":"<div><p>In this study, Sediment Microbial Fuel Cells (SMFCs) prototypes have been developed to operate under open-air conditions and power sensors for environmental monitoring. Two SMFCs with a volume of 50 l each, consisting of two types of anodic materials – graphite and coke, were operated on-field for over a year. The electrical outputs have been recorded and compared with the measured environmental parameters such as temperature, light illumination, atmospheric pressure, humidity, etc. The statistical analysis of the obtained data shows that temperature changes between 0 and 14 °C do not affect the power achieved. On the contrary, the sunlight irradiation showed a second-order polynomial correlation with the current generated by the SMFCs, increasing the latter during the days. The cathode reactions significantly impacted the power density achieved by both explored SMFCs and the system's sustainability. The metallurgical coke is suggested to be used as an inexpensive and convenient anode material for SMFCs giving compatible results to the widely used graphite.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"46 ","pages":"Article 100695"},"PeriodicalIF":5.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000771/pdfft?md5=3a17b815f27cdcfc792216ddf48478e1&pid=1-s2.0-S2214180424000771-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in biosensors for analysis of DNA/RNA methylation 用于分析 DNA/RNA 甲基化的生物传感器的最新进展

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-09-17 DOI: 10.1016/j.sbsr.2024.100690

Zhensheng Ma , Yue Hu , Lina Wang , Mimi Li , Chenghong Li , Lulu Li , Hui Huang , Lichao Fang , Xiaolong Wang , Huamin Liu , Junsong Zheng

{"title":"Recent advances in biosensors for analysis of DNA/RNA methylation","authors":"Zhensheng Ma , Yue Hu , Lina Wang , Mimi Li , Chenghong Li , Lulu Li , Hui Huang , Lichao Fang , Xiaolong Wang , Huamin Liu , Junsong Zheng","doi":"10.1016/j.sbsr.2024.100690","DOIUrl":"10.1016/j.sbsr.2024.100690","url":null,"abstract":"<div><div>DNA and RNA methylation are essential epigenetic modifications that play a pivotal role in various physiological processes by modulating gene expression at the post-transcriptional level. Abnormal DNA/RNA methylation is closely linked to a range of human diseases, including cancer and neurological disorders. Therefore, the accurate and sensitive detection of DNA/RNA methylation is of great importance in both epigenetic biology research and disease diagnosis. Technological advancements have led to the comprehensive development of methylation detection methods. Among these, electrochemical techniques have garnered significant attention owing to their simplicity and effectiveness in detection. This review provides an overview of methylation detection technologies based on electrochemical principles developed over the past five years, including electrochemical, photoelectrochemical, electrochemiluminescence, and fluorescence methodologies. Additionally, it discusses the advantages and disadvantages of these approaches, challenges and advancements in methylation detection.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"46 ","pages":"Article 100690"},"PeriodicalIF":5.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000722/pdfft?md5=013c91cfee8b15ef060b7e5f97b61ae8&pid=1-s2.0-S2214180424000722-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical biosensor based on the dual-functional gold nanoparticles for rapid and accurate multiplex detection of influenza A and B viruses 基于双功能金纳米粒子的光学生物传感器，用于快速准确地多重检测甲型和乙型流感病毒

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-09-17 DOI: 10.1016/j.sbsr.2024.100689

Yuhan Zhang , Shixi Zhang , Huiyi Wang , Mathias Charconnet , Jiaye Jiang , Yuan Peng , Lei Zhang , Charles H. Lawrie

{"title":"Optical biosensor based on the dual-functional gold nanoparticles for rapid and accurate multiplex detection of influenza A and B viruses","authors":"Yuhan Zhang , Shixi Zhang , Huiyi Wang , Mathias Charconnet , Jiaye Jiang , Yuan Peng , Lei Zhang , Charles H. Lawrie","doi":"10.1016/j.sbsr.2024.100689","DOIUrl":"10.1016/j.sbsr.2024.100689","url":null,"abstract":"<div><p>Due to the global pandemic of influenza and related respiratory diseases, rapid and accurate detection is in high demand to control virus spread and facilitate early treatment. However, most current molecular detection methods either require long turnaround times, suffer from low sensitivity and/or can only detect single pathogens. To overcome these challenges, we constructed a novel colorimetric gold nanoparticle (AuNPs) biosensor containing functionalized probes to detect multiple targets simultaneously. Utilizing the salt aging method, AuNPs were functionalized by the designed oligonucleotides to fabricate biosensors. This biosensor can show visible color change within 20 min, and could minimally detect the target influenza viruses at 10 nM. This detection technique presents high sensitivity in a short time, meanwhile identifying two different influenza viruses simultaneously. It opens a window to a multiplex-in-one strategy for a clinical viral diagnostic.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"46 ","pages":"Article 100689"},"PeriodicalIF":5.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000710/pdfft?md5=864f9623a0c5976f614318c306195d1c&pid=1-s2.0-S2214180424000710-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green and real-time detection of GHB in soft drinks and alcoholic beverages using an eco-friendly cellulose paper-based fluorescent probe 使用环保型纤维素纸基荧光探针对软饮料和酒精饮料中的伽马--羟丁酸进行绿色实时检测

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-09-17 DOI: 10.1016/j.sbsr.2024.100691

Jordi Hernández-Contreras , Jordi Roig-Rubio , Margarita Parra , Salvador Gil , Pau Arroyo , José A. Sáez , Carlos Lodeiro , Pablo Gaviña

{"title":"Green and real-time detection of GHB in soft drinks and alcoholic beverages using an eco-friendly cellulose paper-based fluorescent probe","authors":"Jordi Hernández-Contreras , Jordi Roig-Rubio , Margarita Parra , Salvador Gil , Pau Arroyo , José A. Sáez , Carlos Lodeiro , Pablo Gaviña","doi":"10.1016/j.sbsr.2024.100691","DOIUrl":"10.1016/j.sbsr.2024.100691","url":null,"abstract":"<div><p>Chemical submission, a nefarious tactic increasingly employed in criminal activities, has spurred urgent calls for innovative countermeasures. GHB, often dubbed “liquid ecstasy,” stands out as a favoured agent for its surreptitious nature and seamless solubility in water and alcoholic beverages. Addressing this menace head-on, a groundbreaking study delves into the development of advanced chemosensors, leveraging 2-aminonaphtoxazole- and benzoxazole-based compounds adorned with fluorescein, to construct a cellulose paper-based detection system. This ingenious setup not only detects GHB in water but extends its vigilance to real alcoholic and non-alcoholic beverages, illuminating a pathway to thwart potential assailants. With a fluorescence enhancement mechanism at play, the system boasts a dynamic range from 0 to 125 mM GHB in water, exhibiting a commendable limit of detection (LOD) at 7.3 mM. Crucially, its eco-friendly nature, devoid of solvent residuals, underscores its suitability as a proactive shield against chemical submission, embodying a beacon of hope in the fight against such insidious threats to public safety.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"46 ","pages":"Article 100691"},"PeriodicalIF":5.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000734/pdfft?md5=e389b99fa02c13e205c630790ec87504&pid=1-s2.0-S2214180424000734-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic nanoparticles and quantum dots coupled immuno nano fluorescence assay for visual detection of HPV16-induced cervical cancer cells from cytology/biopsy samples 磁性纳米粒子和量子点耦合免疫纳米荧光检测法，用于从细胞学/活检样本中直观检测 HPV16 诱导的宫颈癌细胞

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-09-17 DOI: 10.1016/j.sbsr.2024.100693

Srishty Raman , Pranay Tanwar , Jyoti Meena , Neerja Bhatla , Subhash C. Yadav

{"title":"Magnetic nanoparticles and quantum dots coupled immuno nano fluorescence assay for visual detection of HPV16-induced cervical cancer cells from cytology/biopsy samples","authors":"Srishty Raman , Pranay Tanwar , Jyoti Meena , Neerja Bhatla , Subhash C. Yadav","doi":"10.1016/j.sbsr.2024.100693","DOIUrl":"10.1016/j.sbsr.2024.100693","url":null,"abstract":"<div><p>Biopsy-based histopathology and immunohistochemistry for cervical cancer detection are costly, time-consuming, and require expert personnel for data interpretation. We developed a simple magnetic nanoparticle (MNPs) and quantum dots (QD) coupled immuno nano fluorescence assay (MNPQDCINFA) for visual detection of HPV16-induced cervical cancer cells under UV light from cytology/biopsy samples exploiting host cancer cells expressing viral E7 protein as a biomarker. The E7 domain-specific polyclonal antibodies were generated against the 1–44 amino acid N-terminal (anti-domainN antibody) and 48–98 amino acid C-terminal domain (anti-domainC antibody). These antibodies were bioconjugated with nonfluorescent MNPs (60 % efficiency) and fluorescent QDs (66 % efficiency) to generate capturing (MNPs-anti-domainN antibody) and detecting (QDs-anti-domainC antibody) nano-complex, respectively. Assay conditions, such as concentration of capturing (20 μM) and detecting (50 nM) antibody nano-complexes and incubation duration (30 min), were standardized. The analytical sensitivity using pure HPV16 E7 protein was recorded up to 200 ng with very high specificity to differentiate from other HPV strains E7 proteins. The diagnostic performance characteristics with cytology samples showed 100 % sensitivity and specificity compared to immunofluorescence and biopsy-based histopathology analysis. The present invention can be effectively used for a quick, disposable, rapid cervical cancer cell detection system as an alternate test for immunofluorescence and histopathology.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"46 ","pages":"Article 100693"},"PeriodicalIF":5.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000758/pdfft?md5=74149227605c0a3b27f9a96f66efbae5&pid=1-s2.0-S2214180424000758-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CO2 sensing via periodic Array of graphene disks 通过石墨烯圆盘的周期性阵列实现二氧化碳传感

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-09-17 DOI: 10.1016/j.sbsr.2024.100696

Mansour Rezapour Gatabi , Seyed Saleh Ghoreishi Amiri , Reza Yousefi , Hadi Dehbovid , Amard Afzalian

引用次数: 0

A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillary 基于毛细管纵向导波的小体积样品粘度快速非浸没测量法

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-09-17 DOI: 10.1016/j.sbsr.2024.100692

Shaohong Qu , Songli Hu , Ting Li , Chaomin Wu , Yuexiu Chen , Linqian Zhao , Lihang Zhu , Jianjun Wu , Zhifeng Tang , Peifang Dong , Fengjiang Zhang

{"title":"A rapid and non-immersed method of viscosity measurement with small-volume samples based on longitudinal guided waves in capillary","authors":"Shaohong Qu , Songli Hu , Ting Li , Chaomin Wu , Yuexiu Chen , Linqian Zhao , Lihang Zhu , Jianjun Wu , Zhifeng Tang , Peifang Dong , Fengjiang Zhang","doi":"10.1016/j.sbsr.2024.100692","DOIUrl":"10.1016/j.sbsr.2024.100692","url":null,"abstract":"<div><div>Viscosity measurement is crucial in medical diagnostics, pharmaceuticals, and analytical chemistry, where samples are frequently in small volumes and measurements are supposed to be conducted in a short time with convenient approaches. In this study, we propose a viscosity measurement approach based on longitudinal guided waves with a dominant in-plane displacement. The viscosity is determined using the attenuation of longitudinal guided waves in a liquid-filled capillary. The use of guided waves accelerates the measurement while the application of a capillary reduces the sample volume. Additionally, the approach is nondestructive and repeatable since the liquid sample is injected into the capillary instead of immersing the probe into the liquid; the sample is located in a relatively closed tube, reducing the interferences of outside factors. In our propomsed method, the sample volume is only 176.6 μL and the measurement time of one sample is only 5.6 ms. The effectiveness and practicability of the proposed approach is confirmed by measuring silicon oils with viscosities from 9.01 mPa·s to 532 mPa·s and a limit of detection (LOD) of 0.97 mPa·s. The minimum error is about 5 % at 442 mPa·s and the maximum error is about 18 % at 9.01 mPa·s Besides, the approach was employed for detection of viscosity in artificial tear samples, which indicated that satisfactory applicability was achieved. This work not only demonstrates the judicious design of a rapid and non-immersed method for viscosity measurement, but also a promising scheme for point-of-care analysis of tear viscosity, thus offering great potential for at-home diagnosis and personalized healthcare of various ocular diseases.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"46 ","pages":"Article 100692"},"PeriodicalIF":5.4,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142327762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosensing in the optical switch configuration on strong plasmonic gratings enabling differential referenced detection 在强等离子光栅的光学开关配置中进行生物传感，实现差分参考检测

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-08-01 DOI: 10.1016/j.sbsr.2024.100681

Emilie Laffont , Arnaud Valour , Nicolas Crespo-Monteiro , Pierre Berini , Yves Jourlin

{"title":"Biosensing in the optical switch configuration on strong plasmonic gratings enabling differential referenced detection","authors":"Emilie Laffont , Arnaud Valour , Nicolas Crespo-Monteiro , Pierre Berini , Yves Jourlin","doi":"10.1016/j.sbsr.2024.100681","DOIUrl":"10.1016/j.sbsr.2024.100681","url":null,"abstract":"<div><p>A deep gold-coated sinusoidal grating is proposed as a transducer for label-free real-time biosensing, operating in a new configuration based on the optical switch effect, which produces complementary optical outputs enabling differential and referenced detection. Biosensing experiments are reported for the first time on this platform, using immunoassays involving biospecific pairs consisting of bovine serum albumin and its antibody, and human serum albumin and its antibody. Direct and sandwich immunoassays are demonstrated along with negative controls. A limit of detection of 6 pg/mm<sup>2</sup> was obtained. A theoretical model correlating the variation in the differential referenced output optical signal with adlayer growth is presented and supports the experimental results. The proposed detection device operating in the optical switch configuration makes a promising case for point-of-care detection applications because the differential detection of two diffracted orders enables common noise suppression and robust interrogation.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"45 ","pages":"Article 100681"},"PeriodicalIF":5.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000631/pdfft?md5=82c8610a8f58931ded96d3a1afb0d26f&pid=1-s2.0-S2214180424000631-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142041129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of hexagonal shaped spectroscopy based biosensor for the detection of tuberculosis 设计基于六角形光谱的结核病检测生物传感器

IF 5.4

Sensing and Bio-Sensing Research Pub Date : 2024-08-01 DOI: 10.1016/j.sbsr.2024.100682

Rakib Hossen , Md. Selim Hossain , Sadia Afrin Mim , Md. Al-Amin , Sabbir Ahmed , Md. Ashrafuzzaman , Md. Ashiq Salahin , Shuvo Sen

{"title":"Design of hexagonal shaped spectroscopy based biosensor for the detection of tuberculosis","authors":"Rakib Hossen , Md. Selim Hossain , Sadia Afrin Mim , Md. Al-Amin , Sabbir Ahmed , Md. Ashrafuzzaman , Md. Ashiq Salahin , Shuvo Sen","doi":"10.1016/j.sbsr.2024.100682","DOIUrl":"10.1016/j.sbsr.2024.100682","url":null,"abstract":"<div><p>A proposal has been made to identify tuberculosis cells using a novel compact sensor based on photonic crystal fiber: PCF in accordance with hexagonal spectroscopy. This proposed structure, which consists of a closely packed hexagonal air hole in the cladding region and a hollow-core area, possesses a very low loss of 6.30 × 10<sup>−8</sup> dB/m and an exceptionally high sensitivity of up to 91.75 % (tuberculosis cell for 1.345). Numerous optical parameters have been identified and assessed, comprised of the numerical aperture, the V-parameter, or normalized frequency (V<sub>eff</sub>), and the effective area (A<sub>eff</sub>). The operational wavelength range is defined as 0.80–3.0 THz. The numerical investigation of the properties of the proposed TB sensors is performed within the environment of COMSOL Multiphysics (Version 5.3) using FV-FEM stands for the full vector finite element method. PCF sensors composed of hexagonal lattice in a circular form with ZEONEX as the backdrop material is intended to boost the sensitivity response in comparison to the earlier works. Additionally, the sensor that is being displayed achieves a single modality throughout its whole operational wavelength range. This proposed sensor may play a significant role in identifying tuberculosis thanks to its superior sensitivity response and extremely minimal confinement loss. So, it is clearly seen that this sensor could be used to bio-medical sectors with process of terahertz (THz) wave pulse.</p></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"45 ","pages":"Article 100682"},"PeriodicalIF":5.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214180424000643/pdfft?md5=7c54a42c5e807d84b2c1af5ebcafa53e&pid=1-s2.0-S2214180424000643-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142136697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0