Sensing and Bio-Sensing Research最新文献

{"title":"Currently available technologies for continuous sodium monitoring in plasma or interstitial fluid: A scoping review","authors":"Yu Zhang ,&nbsp;Hanneke M. van Santen ,&nbsp;Ruben E.A. Musson ,&nbsp;Panos Markopoulos ,&nbsp;Yuan Lu","doi":"10.1016/j.sbsr.2025.100850","DOIUrl":"10.1016/j.sbsr.2025.100850","url":null,"abstract":"<div><div>The human body maintains plasma sodium concentration within a narrow range of 135 to 145 mmol/L to ensure homeostasis. Being outside this range denotes hyponatremia (below 135 mmol/L) or hypernatremia (above 145 mmol/L), which can cause serious health problems. Current sodium monitoring is performed using point-of-care devices, which require blood sampling every time. It is cumbersome and uncomfortable for patients who require frequent sodium measurements daily. It would be ideal to continuously monitor plasma sodium concentration to reduce burden and detect abnormalities earlier. The sodium concentration in interstitial fluid is close to plasma sodium. Thus, this scoping review presents the current technological developments for continuous sodium monitoring (CSM) in plasma or interstitial fluid. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis extension for Scoping Reviews (PRISMA-ScR) checklist. 11 articles that presented technologies for the continuous monitoring of sodium concentrations in plasma or interstitial fluid with at least a technology readiness level of four were included for review. Seven of them presented microneedle(MN)-based solutions for CSM, and the remaining four were fluorescence(FS)-based. MN-based sodium sensors are all-solid-state sodium ion-selective electrodes designed as MN arrays or standalone MNs. FS-based CSM technologies inject sodium-sensitive fluorophores into the bloodstream or subcutaneously to reflect local sodium concentrations. Comparison of these two technological paths based on expected patient experience revealed that MN-based technologies appear more feasible for daily use and promising for further development due to their minimal invasiveness and compact wearability.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100850"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability insights into synthetic biology enabled biosensors: A case study with SARS-CoV2 toehold-based colorimetric sensor","authors":"Swetha Mariam Stanley,&nbsp;Harvinder Khera","doi":"10.1016/j.sbsr.2025.100775","DOIUrl":"10.1016/j.sbsr.2025.100775","url":null,"abstract":"<div><div>Improving medical and environmental diagnostics has become a pressing need. Synthetic biologists are steering biomolecular engineering efforts toward this objective, promising novel, cost-effective diagnostic solutions. While conventional antibody-based diagnostics are sensitive, they are slow, costly, and struggle with emerging pathogens or rare diseases. Synthetic biology's rapid design-to-production cycles offer a solution, introducing engineered gene circuits that diversify molecular detection, create dynamic sensors, and enable portable diagnostic tools. Toehold switch-based diagnostics emerge as a promising, inexpensive, rapid, and highly sensitive alternative to RT-qPCR, especially beneficial in resource-limited regions. These devices, adaptable to paper-based platforms, offer potential for widespread use in low-resource settings. Ensuring stability and functionality under varying environmental factors poses a challenge in their practical implementation for diagnostic purposes. To address this, our study focuses on preserving cell fee expression systems under extended temperature stress through lyophilization. Lyophilization emerges as a crucial method, potentially ensuring prolonged stability and convenient transportation of diagnostic components. We emphasize the significance of choosing the appropriate lyoprotectant, underscoring the necessity of exploring various lyoprotectants to ensure scalability and cost-effectiveness in these molecular tools. Our demonstration of dextran's practical utility in enhancing the stability of lyophilized cell-free expression system for colorimetric diagnostics, especially in detecting synthetic triggers for SARS-CoV-2, signifies a promising advancement in molecular diagnostics for resource-limited settings.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100775"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molybdenum diselenide-based optical fiber biosensors for targeted detection of lung cancer-associated DNA","authors":"Hamed Taheri ,&nbsp;Maryam Nayeri ,&nbsp;Navid Nasirizadeh ,&nbsp;Seyed Morteza Seifati ,&nbsp;Fatemeh Ostovari","doi":"10.1016/j.sbsr.2025.100859","DOIUrl":"10.1016/j.sbsr.2025.100859","url":null,"abstract":"<div><div>The emergence of molybdenum diselenide as a nanomaterial with unique electronic, mechanical, chemical, and optical properties has significantly advanced research in various biomedical sciences and the development of biosensors for biomolecule analysis. This research introduces a molybdenum diselenide-based biosensor to identify DNA molecules related to lung cancer. To stabilize single-stranded DNA containing a thiol group on the optical fiber surface, key parameters in the biosensor, such as stability time, solution concentration, and input power for single-stranded DNA molecules, were optimized. The hybridization process and the time required for it were evaluated, and the effect of the target molecule quantity on the limit of detection was analyzed. The results from the biosensor showed a significant increase in the optical refractive index in the optical fiber with two complementary strands compared to a single strand. In contrast, the hybridization process with non-complementary strands indicated minimal effect. The sensor demonstrated high effectiveness and selectivity in identifying single strands of DNA. Analytical properties such as linearity, detection limit, and repeatability were assessed for the designed sensor. The results indicate that it can detect concentrations from 1000 nM to 0.07 nM, with a detection limit of 88.58 pM. Its response speed is just one second, and it outperforms other sensors. Identification, early diagnosis, advanced awareness, and follow-up of lung cancer are crucial factors that can significantly facilitate treatment.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100859"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable electric split-ring resonator with multi-functional modulation characteristics","authors":"Wenqing Zheng,&nbsp;Daoye Zheng,&nbsp;Yunche Zhu,&nbsp;Tingwei Wang,&nbsp;Yu-Sheng Lin","doi":"10.1016/j.sbsr.2025.100857","DOIUrl":"10.1016/j.sbsr.2025.100857","url":null,"abstract":"<div><div>This study presents an electrostatically tunable electric split-ring resonator (eSRR) design to investigate its applications in optical modulations and environmental monitors. The eSRR consists of four meta-atoms (MAs) that are centrally symmetric and free to move horizontally and vertically. Each MA is composed of a L-shaped metal structure on silicon nitride (Si₃N₄) layer. By changing the gap between MAs in <em>x</em>-axis (<em>d</em>_<em>x</em>) and <em>y</em>-axis directions (<em>d</em>_<em>y</em>), and height (<em>h</em>) of MAs, the active switching and dynamic modulating behaviors of seven distinct resonance modes are achieved in the eSRR design. The MAs exhibit translational displacement along individual <em>x</em>- and <em>y</em>-axes, as well as <em>x-y</em> planar motion simultaneously. The eSRR demonstrates broadband frequency tuning with 0.41 THz spectral shift via <em>x</em>-axis displacement in TE mode, while <em>y</em>-axis displacement enables dual-band optical switching at 0.54 THz and 0.88 THz in TM mode. Along the vertical direction, the optical properties of the eSRR are systematically investigated by lifting a single MA, two diagonally arranged MAs, and two adjacent MAs. Through changing the <em>h</em> value, eSRR exhibits the switching of single-, dual-, and tri-band resonance characteristics, and reaches the 0.69 resonant intensity in different resonant modes. As the environmental refractive index varies from 1.0 to 2.0, the eSRR demonstrates distinct electromagnetic responses depending on its geometrical parameters. When <em>d</em>_<em>x</em> = 20 μm, <em>d</em>_<em>y</em> = 36 μm, and <em>h</em> = 0 μm, the eSRR shows the maximum sensitivity of 126 GHz/RIU. These results indicate that the proposed eSRR configuration is promising for applications in optical filtering, switching, modulating, biosensing, and environmental monitoring fields.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100857"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Graphene based Mo6 cluster hybrid for detecting simulant nerve agent DMMP” [Sensing and Bio-Sensing Research, Volume 43, February 2024, 100603]","authors":"Juan Casanova-Chafer ,&nbsp;Xavier Blanch ,&nbsp;Ana Moreno ,&nbsp;Rocio Garcia-Aboal ,&nbsp;Pedro Atienzar ,&nbsp;Eduard Llobet ,&nbsp;Marta Feliz","doi":"10.1016/j.sbsr.2025.100863","DOIUrl":"10.1016/j.sbsr.2025.100863","url":null,"abstract":"","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100863"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Surface acoustic waves (SAW) sensor for the active detection of Microcystin-LR (Cyanobacteria)” [Sensing and Bio-Sensing Research, Volume 47, February 2025, 100724]","authors":"Debdyuti Mandal ,&nbsp;Tally Bovender ,&nbsp;Robert D. Geil ,&nbsp;Debabrata Sahoo ,&nbsp;Sourav Banerjee","doi":"10.1016/j.sbsr.2025.100868","DOIUrl":"10.1016/j.sbsr.2025.100868","url":null,"abstract":"","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100868"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Electrochemical modulation of tau protein phosphorylation levels with biomimetic polyaniline membranes” [Sensing and Bio-Sensing Research, Volume 48, June 2025, 100805]","authors":"Shang-Chi Chien ,&nbsp;Chia-Hsuan Chang ,&nbsp;Hung-Ju Wang ,&nbsp;Chien-Chih Hsu ,&nbsp;Yu-Lin Wang ,&nbsp;Ching-Cheng Chuang ,&nbsp;Jung-Chih Chen","doi":"10.1016/j.sbsr.2025.100832","DOIUrl":"10.1016/j.sbsr.2025.100832","url":null,"abstract":"","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100832"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward the development of a square wave voltammetry technique for in situ soil organic carbon quantification","authors":"Matthew Myers ,&nbsp;Praveen ,&nbsp;Stuart Watt ,&nbsp;Wesley Moss ,&nbsp;Joanne Wisdom","doi":"10.1016/j.sbsr.2025.100856","DOIUrl":"10.1016/j.sbsr.2025.100856","url":null,"abstract":"<div><div>Many strategies are being developed and implemented to increase the soil carbon stock; however, demonstrating efficacy is often limited by the time and costs associated with soil sampling/analysis and a lack of real-time data to understand soil carbon spatiotemporal dynamics. As such, the development of real time in-ground sensors for monitoring changes in soil organic carbon over time is necessary to validate (or invalidate) these strategies in the real world. In situ near-IR spectroscopic techniques have been developed for quantifying and characterizing organic carbon in soil. This strategy is strongly affected by soil moisture content, relies on complex statistical and machine learning techniques and is relatively expensive. In this work, we examine the feasibility of developing a low-cost electrochemical technique for the quantification of soluble soil carbon species in soil. Given that these species are very diverse, commercially available fulvic/humic acid is used as a pathway for sensor development. Using a composite film consisting of a poly(methyl methacrylate) resin (to attract fulvic/humic acid to the electrode surface) and a hydrogel material (to bring moisture to the electrode surface), a linear response over a fulvic acid concentration range 0 to 0.05 wt% has been demonstrated. Multi-day measurements in a varying temperature environment have shown that there is a strong correlation between response and temperature. By implementing these correlations and optimizing the coating characteristics, we show that the sensor has a lifetime of over one month in aqueous solution.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100856"},"PeriodicalIF":4.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of copper ions at the sediment-seawater interface through ion-selective microelectrode based on current pulse","authors":"Jiali Zhai ,&nbsp;Yixin Hu ,&nbsp;Mingkang Li ,&nbsp;Hongwei Liu ,&nbsp;Xin Liang ,&nbsp;Jie Rong ,&nbsp;Guangtao Zhao","doi":"10.1016/j.sbsr.2025.100858","DOIUrl":"10.1016/j.sbsr.2025.100858","url":null,"abstract":"<div><div>The chronopotentiometric measurements based on ion-selective microelectrode (ISμE) could be a promising tool for the detection of free copper ion in seawater at the sediment-water interface with high sensitivity. In this work, an all-solid-contact copper ion-selective microelectrode (Cu²⁺-ISμE) based on platinum wire was designed for chronopotentiometric determination of copper in seawater at the sediment-water interface. The lipophilic salt ETH 500 was added into the Cu²⁺-selective membrane instead of traditional ion-exchanger, and the extraction of copper could be galvanostatically controlled. The present chronopotentiometric method shows a linear activity range of 2.5 × 10⁻⁴ - 2.5 × 10⁻⁸ M with a slope of 34.75 ± 0.5 mV/decade under the optimized conditions, and the detection limit is 5.8 × 10⁻⁹ M. Moreover, the chronopotentiometric method has a good selectivity and reproductivity. Additionally, the feasibility of the Cu²⁺-ISμE has been investigated for the measurement of the content of Cu²⁺ in the seawater samples at the sediment-water interface with a small volume (e.g., 1 mL) without any pretreatment, and the spike recovery for this method is from 92.24 % to 106.51 %. Herein, the detection of copper through the pulse current based Cu²⁺-ISμE has satisfactory results. The galvanostatic controlled technique based on ISμE has potential application in the in-situ determination of trace heavy metals in seawater.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100858"},"PeriodicalIF":4.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple-synergistic Mn-MOF electrochemical sensor for multiplex antibiotic detection: A robust and stable platform for food safety monitoring","authors":"Sumei Li ,&nbsp;Bo Yan ,&nbsp;Lulu Liu ,&nbsp;Haiying Yang ,&nbsp;Chengyu Zhang ,&nbsp;Jianli Shi ,&nbsp;Jing Su ,&nbsp;Wenjuan Ji","doi":"10.1016/j.sbsr.2025.100854","DOIUrl":"10.1016/j.sbsr.2025.100854","url":null,"abstract":"<div><div>The excessive use of nitrofurantoin (NFT), nitrofurazone (NFZ), tetracycline hydrochloride (TC), and chloramphenicol (CAP) poses significant health risks due to their toxicity. Existing detection methods are limited in sensitivity and portability, which hinders rapid on-site monitoring of antibiotic residues contemporary livestock production. This study introduces an electrochemical sensor based on {[Mn₂(BPTC)(DMA)₂(H₂O)₂]·DMA}_n (SXNU-2-Mn) (H₄BPTC = biphenyl-3,3′,5,5′-tetracarboxylic acid, DMA = <em>N</em>, <em>N</em>-Dimethylacetamide, SXNU = Shanxi Normal University). The Metal-organic frameworks (MOFs) SXNU-2-Mn features a three-dimensional PtS topology with a unique pore microenvironment containing hydroxyl oxygen groups and DMA molecules, along with its manganese (Mn) catalytic center. The rod-shaped nanometer array of pristine SXNU-2-Mn/GCE sensor demonstrates exceptional performance in detecting and differentiating multiple antibiotics, including NFT, NFZ, TC, and CAP, each with distinct redox potential. Notably, for CAP, the sensor exhibits an extensive linear range from 0.07 to 900.00 μM and an exceptionally much lower limit of detection (LOD) of 19.45 nM. Stability assessments indicate that the sensor retains over 94.6 % of its initial performance after seven days, with a variation of less than 2.4 % for CAP detection. The pore environment facilitates a triple-synergistic smart recognition mechanism for CAP, involving π-π stacking, hydrogen bonding, and Mn(II)-mediated catalytic interactions. The practical applicability of the SXNU-2-Mn/GCE sensor was validated through real-world food samples such as chicken and milk, achieving recovery rates ranging from 95.45 % to 108.10 %. This research presents a pristine MOF platform that integrates molecular recognition and redox catalysis, offering a portable solution for simultaneous antibiotic residue detection and advancing food safety monitoring technologies.</div></div>","PeriodicalId":424,"journal":{"name":"Sensing and Bio-Sensing Research","volume":"49 ","pages":"Article 100854"},"PeriodicalIF":4.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}