Journal of Xenobiotics最新文献_第9页

The Extracellular Vesicles Containing Inorganic Polyphosphate of Candida Yeast upon Growth on Hexadecane. 酵母在十六烷上生长时含有无机多磷酸盐的胞外小泡。

IF 6

Journal of Xenobiotics Pub Date : 2023-09-23 DOI: 10.3390/jox13040034

Anton N Zvonarev, Ludmila V Trilisenko, Vasilina V Farofonova, Ekaterina V Kulakovskaya, Tatiana N Abashina, Vladimir V Dmitriev, Tatiana Kulakovskaya

{"title":"The Extracellular Vesicles Containing Inorganic Polyphosphate of Candida Yeast upon Growth on Hexadecane.","authors":"Anton N Zvonarev, Ludmila V Trilisenko, Vasilina V Farofonova, Ekaterina V Kulakovskaya, Tatiana N Abashina, Vladimir V Dmitriev, Tatiana Kulakovskaya","doi":"10.3390/jox13040034","DOIUrl":"10.3390/jox13040034","url":null,"abstract":"The cell wall of Candida yeast grown on presence of hexadecane as a sole carbon source undergoes structural and functional changes including the formation of specific supramolecular complexes-canals. The canals contain specific polysaccharides and enzymes that provide primary oxidization of alkanes. In addition, inorganic polyphosphate (polyP) was identified in Candida maltosa canals. The aim of the work was a comparative study of the features of cell walls and extracellular structures in yeast C. maltosa, C. albicans and C. tropicalis with special attention to inorganic polyphosphates as possible part of these structures when grown on the widely used xenobiotic hexadecane (diesel fuel). Fluorescence microscopy with DAPI has shown an unusual localization of polyP on the cell surface and in the exovesicles in the three yeast species, when growing on hexadecane. Electron-scanning microscopy showed that the exovesicles were associated with the cell wall and also presented in the external environment probably as biofilm components. Treatment of hexadecane-grown cells with purified Ppx1 polyphosphatase led to the release of phosphate into the incubation medium and the disappearance of polyP in vesicles and cell wall observed using microscopic methods. The results indicate the important role of polyP in the formation of extracellular structures in the Candida yeast when consuming hexadecane and are important for the design of xenobiotic destructors based on yeast or mixed cultures.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"13 4","pages":"529-543"},"PeriodicalIF":6.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49692901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indigo Carmine: Between Necessity and Concern. 靛蓝胭脂红：在需要和关注之间。

IF 6

Journal of Xenobiotics Pub Date : 2023-09-20 DOI: 10.3390/jox13030033

Madalina-Elena Ristea, Otilia Zarnescu

{"title":"Indigo Carmine: Between Necessity and Concern.","authors":"Madalina-Elena Ristea, Otilia Zarnescu","doi":"10.3390/jox13030033","DOIUrl":"https://doi.org/10.3390/jox13030033","url":null,"abstract":"Dyes, such as indigo carmine, have become indispensable to modern life, being widely used in the food, textile, pharmaceutical, medicine, and cosmetic industry. Although indigo carmine is considered toxic and has many adverse effects, it is found in many foods, and the maximum permitted level is 500 mg/kg. Indigo carmine is one of the most used dyes in the textile industry, especially for dyeing denim, and it is also used in medicine due to its impressive applicability in diagnostic methods and surgical procedures, such as in gynecological and urological surgeries and microsurgery. It is reported that indigo carmine is toxic for humans and can cause various pathologies, such as hypertension, hypotension, skin irritations, or gastrointestinal disorders. In this review, we discuss the structure and properties of indigo carmine; its use in various industries and medicine; the adverse effects of its ingestion, injection, or skin contact; the effects on environmental pollution; and its toxicity testing. For this review, 147 studies were considered relevant. Most of the cited articles were those about environmental pollution with indigo carmine (51), uses of indigo carmine in medicine (45), and indigo carmine as a food additive (17).","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"13 3","pages":"509-528"},"PeriodicalIF":6.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Chronic Roundup Exposure on Medaka Larvae. 长期接触农达对Medaka幼虫的影响。

IF 6

Journal of Xenobiotics Pub Date : 2023-09-14 DOI: 10.3390/jox13030032

Deborah Killian, Mehwish Faheem, Beh Reh, Xuegeng Wang, Ramji Kumar Bhandari

{"title":"Effects of Chronic Roundup Exposure on Medaka Larvae.","authors":"Deborah Killian, Mehwish Faheem, Beh Reh, Xuegeng Wang, Ramji Kumar Bhandari","doi":"10.3390/jox13030032","DOIUrl":"https://doi.org/10.3390/jox13030032","url":null,"abstract":"The use of glyphosate-based herbicides is increasing yearly to keep up with the growing demands of the agriculture world. Although glyphosate-based herbicides target the enzymatic pathway in plants, the effects on the endocrine systems of vertebrate organisms, mainly fish, are widely unknown. Many studies with glyphosate used high-exposure concentrations (mg/L), and the effect of environmentally relevant or lower concentrations has not been clearly understood. Therefore, the present study examined the effects of very low, environmentally relevant, and high concentrations of glyphosate exposure on embryo development and the thyroid system of Japanese medaka (Oryzias latipes). The Hd-rR medaka embryos were exposed to Roundup containing 0.05, 0.5, 5, 10, and 20 mg/L glyphosate (glyphosate acid equivalent) from the 8 h post-fertilization stage through the 14-day post-fertilization stage. Phenotypes observed include delayed hatching, increased developmental deformities, abnormal growth, and embryo mortality. The lowest concentration of glyphosate (0.05 mg/L) and the highest concentration (20 mg/L) induced similar phenotypes in embryos and fry. A significant decrease in mRNA levels for acetylcholinesterase (ache) and thyroid hormone receptor alpha (thrα) was found in the fry exposed to 0.05 mg/L and 20 mg/L glyphosate. The present results demonstrated that exposure to glyphosate formulation, at a concentration of 0.05 mg/L, can affect the early development of medaka larvae and the thyroid pathway, suggesting a link between thyroid functional changes and developmental alteration; they also showed that glyphosate can be toxic to fish at this concentration.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"13 3","pages":"500-508"},"PeriodicalIF":6.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41151678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Becoming aWARE: The Development of a Web-Based Tool for Autism Research and the Environment. 成为一个软件：开发一个基于网络的自闭症研究和环境工具。

IF 6.8

Journal of Xenobiotics Pub Date : 2023-09-13 DOI: 10.3390/jox13030031

Anisha Singh, Cindy P Lawler, Vickie R Walker, Katherine E Pelch, Amanda E Garton, Andrew A Rooney, Astrid C Haugen

{"title":"Becoming aWARE: The Development of a Web-Based Tool for Autism Research and the Environment.","authors":"Anisha Singh, Cindy P Lawler, Vickie R Walker, Katherine E Pelch, Amanda E Garton, Andrew A Rooney, Astrid C Haugen","doi":"10.3390/jox13030031","DOIUrl":"10.3390/jox13030031","url":null,"abstract":"A sharp rise in autism spectrum disorder (ASD) prevalence estimates, beginning in the 1990s, suggested factors additional to genetics were at play. This stimulated increased research investment in nongenetic factors, including the study of environmental chemical exposures, diet, nutrition, lifestyle, social factors, and maternal medical conditions. Consequently, both peer- and non-peer-reviewed bodies of evidence investigating environmental contributors to ASD etiology have grown significantly. The heterogeneity in the design and conduct of this research results in an inconclusive and unwieldy 'virtual stack' of publications. We propose to develop a Web-based tool for Autism Research and the Environment (aWARE) to comprehensively aggregate and assess these highly variable and often conflicting data. The interactive aWARE tool will use an approach for the development of systematic evidence maps (SEMs) to identify and display all available relevant published evidence, enabling users to explore multiple research questions within the scope of the SEM. Throughout tool development, listening sessions and workshops will be used to seek perspectives from the broader autism community. New evidence will be indexed in the tool annually, which will serve as a living resource to investigate the association between environmental factors and ASD.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"13 3","pages":"492-499"},"PeriodicalIF":6.8,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41172993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can BPA Analogs Affect Cellular and Biochemical Responses in the Microalga Phaeodactylum tricornutum Bohlin? BPA类似物能影响三角藻Bohlin的细胞和生化反应吗？

IF 6

Journal of Xenobiotics Pub Date : 2023-09-08 DOI: 10.3390/jox13030030

Jacopo Fabrello, Maria Ciscato, Emanuela Moschin, Francesca Dalla Vecchia, Isabella Moro, Valerio Matozzo

引用次数: 0

Mercury Content in Impacted Wisdom Teeth from Patients of the Legnica-Głogów Copper Area-An In Vitro Pilot Study. Legnica-Głogów铜区患者患智齿中汞含量的体外初步研究。

IF 6

Journal of Xenobiotics Pub Date : 2023-08-27 DOI: 10.3390/jox13030029

Sadri Rayad, Maciej Dobrzyński, Amadeusz Kuźniarski, Marzena Styczyńska, Dorota Diakowska, Tomasz Gedrange, Sylwia Klimas, Tomasz Gębarowski, Marzena Dominiak

{"title":"Mercury Content in Impacted Wisdom Teeth from Patients of the Legnica-Głogów Copper Area-An In Vitro Pilot Study.","authors":"Sadri Rayad, Maciej Dobrzyński, Amadeusz Kuźniarski, Marzena Styczyńska, Dorota Diakowska, Tomasz Gedrange, Sylwia Klimas, Tomasz Gębarowski, Marzena Dominiak","doi":"10.3390/jox13030029","DOIUrl":"https://doi.org/10.3390/jox13030029","url":null,"abstract":"The aim of this study was to determine the content of mercury in impacted third molars from Legnica-Głogów Copper Area residents to emphasize the effects of environmental pollution on the human body. A group of 72 patients with an average age of 27.3 ± 6.9 years participated in the study. Within this study, the research group (Legnica-Głogów Copper Area residents) comprised 51 individuals, while the control group (residents of Wrocław) consisted of 21 participants. A higher number of female individuals participated in the research (55). The amount of mercury present in the samples was determined through atomic absorption spectrometry with the use of a SpectraAA atomic absorption spectrometer and a V2 AA240FS flame attachment that utilized an air-acetylene flame. The accumulation of Hg in the teeth of members of the control group residing in Wrocław was studied, with a focus on identifying the risk factors that contribute to this phenomenon. The final model analyzed the presence of various factors, including thyroid and parathyroid gland diseases, cardiac diseases, and interval-scale Vit. D3 concentration. Among these factors, the presence of cardiac diseases was deemed statistically significant in relation to an increase in Hg concentration in third molars (rate ratio = 2.27, p < 0.0001). The concentration of mercury increased with the age and time of residence in the L-G Copper District.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"13 3","pages":"463-478"},"PeriodicalIF":6.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10532917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41153311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organochlorine Compounds in the Amur (Heilong) River Basin (2000-2020): A Review. 阿穆尔河(黑龙江)流域有机氯化合物(2000-2020)研究进展

IF 6

Journal of Xenobiotics Pub Date : 2023-08-20 DOI: 10.3390/jox13030028

Maksim M Donets, Vasiliy Yu Tsygankov

引用次数: 0

The Microbiome and Antibiotic Resistome in Soil under Biodegradable Composite Carbon Source Amendment. 可生物降解复合碳源改良下土壤微生物组和抗生素抗性组的研究

IF 6

Journal of Xenobiotics Pub Date : 2023-08-15 DOI: 10.3390/jox13030027

Zhongchen Yang, Yanhong Lou, Xianghui Yan, Hong Pan, Hui Wang, Quangang Yang, Yajie Sun, Yuping Zhuge

{"title":"The Microbiome and Antibiotic Resistome in Soil under Biodegradable Composite Carbon Source Amendment.","authors":"Zhongchen Yang, Yanhong Lou, Xianghui Yan, Hong Pan, Hui Wang, Quangang Yang, Yajie Sun, Yuping Zhuge","doi":"10.3390/jox13030027","DOIUrl":"https://doi.org/10.3390/jox13030027","url":null,"abstract":"The decomposition of biodegradable composite carbon sources generates a large amount of biodegradable microplastics, which may not only furnish microbial denitrification, but might also pose potential environmental risks. In the present study, the effects of different dosages of a biodegradable composite carbon source on the microbial communities, the nitrogen metabolic pathways and the antibiotic resistome were explored through Illumina MiSeq sequencing analysis and metagenomic analysis. The results of partial least-square discriminant analysis (PLS-DA) and analysis of similarity (ANOSIM) demonstrated that the response of the bacterial community to a biodegradable composite carbon source was more obvious than the fungal community. The application of biodegradable microplastics diminished the complexity of the microbial communities to some extent and obviously stimulated denitrification. Antibiotics resistance gene (ARG) dispersal was not evidently accelerated after the addition of biodegradable composite carbon source. Lysobacter, Methylobacillus, Phyllobacterium, Sinorhizobium, Sphingomonas from Proteobacteria and Actinomadura, Agromyces, Gaiella and Micromonospora from Actinobacteria were the major ARG hosts. Overall, the addition of a biodegradable composite carbon source shaped microbial communities and their antibiotic resistance profiles in this study.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"13 3","pages":"424-438"},"PeriodicalIF":6.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10055242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytochrome P450 Gene Families: Role in Plant Secondary Metabolites Production and Plant Defense. 细胞色素P450基因家族:在植物次生代谢产物产生和植物防御中的作用。

IF 6

Journal of Xenobiotics Pub Date : 2023-07-25 DOI: 10.3390/jox13030026

Panchali Chakraborty, Ashok Biswas, Susmita Dey, Tuli Bhattacharjee, Swapan Chakrabarty

{"title":"Cytochrome P450 Gene Families: Role in Plant Secondary Metabolites Production and Plant Defense.","authors":"Panchali Chakraborty, Ashok Biswas, Susmita Dey, Tuli Bhattacharjee, Swapan Chakrabarty","doi":"10.3390/jox13030026","DOIUrl":"https://doi.org/10.3390/jox13030026","url":null,"abstract":"Cytochrome P450s (CYPs) are the most prominent family of enzymes involved in NADPH- and O2-dependent hydroxylation processes throughout all spheres of life. CYPs are crucial for the detoxification of xenobiotics in plants, insects, and other organisms. In addition to performing this function, CYPs serve as flexible catalysts and are essential for producing secondary metabolites, antioxidants, and phytohormones in higher plants. Numerous biotic and abiotic stresses frequently affect the growth and development of plants. They cause a dramatic decrease in crop yield and a deterioration in crop quality. Plants protect themselves against these stresses through different mechanisms, which are accomplished by the active participation of CYPs in several biosynthetic and detoxifying pathways. There are immense potentialities for using CYPs as a candidate for developing agricultural crop species resistant to biotic and abiotic stressors. This review provides an overview of the plant CYP families and their functions to plant secondary metabolite production and defense against different biotic and abiotic stresses.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"13 3","pages":"402-423"},"PeriodicalIF":6.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10055246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbiome: The Next Frontier in Psychedelic Renaissance. 微生物组：迷幻文艺复兴的下一个前沿。

IF 6

Journal of Xenobiotics Pub Date : 2023-07-25 DOI: 10.3390/jox13030025

Robert B Kargbo

{"title":"Microbiome: The Next Frontier in Psychedelic Renaissance.","authors":"Robert B Kargbo","doi":"10.3390/jox13030025","DOIUrl":"10.3390/jox13030025","url":null,"abstract":"The psychedelic renaissance has reignited interest in the therapeutic potential of psychedelics for mental health and well-being. An emerging area of interest is the potential modulation of psychedelic effects by the gut microbiome-the ecosystem of microorganisms in our digestive tract. This review explores the intersection of the gut microbiome and psychedelic therapy, underlining potential implications for personalized medicine and mental health. We delve into the current understanding of the gut-brain axis, its influence on mood, cognition, and behavior, and how the microbiome may affect the metabolism and bioavailability of psychedelic substances. We also discuss the role of microbiome variations in shaping individual responses to psychedelics, along with potential risks and benefits. Moreover, we consider the prospect of microbiome-targeted interventions as a fresh approach to boost or modulate psychedelic therapy's effectiveness. By integrating insights from the fields of psychopharmacology, microbiology, and neuroscience, our objective is to advance knowledge about the intricate relationship between the microbiome and psychedelic substances, thereby paving the way for novel strategies to optimize mental health outcomes amid the ongoing psychedelic renaissance.","PeriodicalId":42356,"journal":{"name":"Journal of Xenobiotics","volume":"13 3","pages":"386-401"},"PeriodicalIF":6.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10060882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0