The Exposome and the Kidney: A Silent Dialogue Shaping Chronic Kidney Disease.

IF 6.8 Q1 TOXICOLOGY

Journal of Xenobiotics Pub Date : 2025-05-14 DOI:10.3390/jox15030073

Livia Alvarenga, Marcia Ribeiro, Ludmila F M F Cardozo, Natália A Borges, Peter Stenvinkel, Denise Mafra

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引用次数: 0

Abstract

Genetic predisposition accounts for less than 20% of the global disease burden, highlighting the substantial role of environmental factors in health outcomes. In chronic kidney disease (CKD), a growing global prevalence, understanding the interplay between genes and the environment is crucial. Emerging research in the exposome and genome underscores how environmental exposures interact with genetic variants to influence the development and progression of CKD. The term "exposome" encompasses a variety of factors, including personal behaviors like smoking, a sedentary lifestyle, and making specific dietary choices (such as consuming ultra-processed foods, sugar, or fat). It also includes broader determinants such as pesticides, air, water, and soil pollution, nanoplastics, global warming, stressful life events, and socioeconomic status. Research on the exposome significantly increases our understanding of toxicological processes and individual variations in susceptibility to environmental stressors. This narrative review aims to explore the exposome associated with CKD, highlight key environmental exposures in its development, and discuss potential preventive and therapeutic strategies informed by these exposure-related factors.

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暴露体与肾脏：形成慢性肾脏疾病的无声对话。

遗传易感性占全球疾病负担的不到20%，突出了环境因素在健康结果中的重要作用。慢性肾脏疾病（CKD）的全球患病率日益上升，了解基因与环境之间的相互作用至关重要。暴露体和基因组的新兴研究强调了环境暴露如何与遗传变异相互作用，从而影响CKD的发生和进展。“暴露”一词包含多种因素，包括吸烟、久坐不动的生活方式等个人行为，以及特定的饮食选择（如食用超加工食品、糖或脂肪）。它还包括更广泛的决定因素，如农药、空气、水和土壤污染、纳米塑料、全球变暖、生活压力事件和社会经济地位。对暴露体的研究大大增加了我们对毒理学过程和个体对环境压力易感性变化的理解。本文旨在探讨CKD的相关暴露，强调CKD发展中的关键环境暴露，并讨论这些暴露相关因素的潜在预防和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Xenobiotics TOXICOLOGY-

CiteScore

5.30

自引率

1.70%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Xenobiotics publishes original studies concerning the beneficial (pharmacology) and detrimental effects (toxicology) of xenobiotics in all organisms. A xenobiotic (“stranger to life”) is defined as a chemical that is not usually found at significant concentrations or expected to reside for long periods in organisms. In addition to man-made chemicals, natural products could also be of interest if they have potent biological properties, special medicinal properties or that a given organism is at risk of exposure in the environment. Topics dealing with abiotic- and biotic-based transformations in various media (xenobiochemistry) and environmental toxicology are also of interest. Areas of interests include the identification of key physical and chemical properties of molecules that predict biological effects and persistence in the environment; the molecular mode of action of xenobiotics; biochemical and physiological interactions leading to change in organism health; pathophysiological interactions of natural and synthetic chemicals; development of biochemical indicators including new “-omics” approaches to identify biomarkers of exposure or effects for xenobiotics.