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Benefit of vutrisiran in transthyretin amyloidosis with cardiomyopathy 经甲状腺素淀粉样变性伴心肌病患者服用武曲地兰的益处
IF 41.7 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-19 DOI: 10.1038/s41569-024-01086-y
Gregory B. Lim
{"title":"Benefit of vutrisiran in transthyretin amyloidosis with cardiomyopathy","authors":"Gregory B. Lim","doi":"10.1038/s41569-024-01086-y","DOIUrl":"10.1038/s41569-024-01086-y","url":null,"abstract":"Data from the HELIOS-B trial show that RNA interference with vutrisiran reduces the risk of death and recurrent cardiovascular events in patients with transthyretin amyloidosis with cardiomyopathy.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 11","pages":"740-740"},"PeriodicalIF":41.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women 综合衡量炎症、胆固醇和脂蛋白（a）可预测女性 30 年的心血管风险
IF 41.7 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01082-2
Karina Huynh
{"title":"Combined measure of inflammation, cholesterol and lipoprotein(a) predicts 30-year cardiovascular risk in women","authors":"Karina Huynh","doi":"10.1038/s41569-024-01082-2","DOIUrl":"10.1038/s41569-024-01082-2","url":null,"abstract":"A single combined measurement of high-sensitivity C-reactive protein, LDL-cholesterol and lipoprotein(a) levels in plasma predicts incident cardiovascular events among women over a 30-year follow-up period, according to a new study.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 11","pages":"741-741"},"PeriodicalIF":41.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reproductive options and genetic testing for patients with an inherited cardiac disease 遗传性心脏病患者的生殖选择和基因检测
IF 49.6 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01073-3
Job A. J. Verdonschot, Aimee D. C. Paulussen, Neal K. Lakdawala, Christine E. M. de Die-Smulders, James S. Ware, Jodie Ingles
{"title":"Reproductive options and genetic testing for patients with an inherited cardiac disease","authors":"Job A. J. Verdonschot, Aimee D. C. Paulussen, Neal K. Lakdawala, Christine E. M. de Die-Smulders, James S. Ware, Jodie Ingles","doi":"10.1038/s41569-024-01073-3","DOIUrl":"https://doi.org/10.1038/s41569-024-01073-3","url":null,"abstract":"<p>In the past decade, genetic testing for cardiac disease has become part of routine clinical care. A genetic diagnosis provides the possibility to clarify risk for relatives. For family planning, a genetic diagnosis provides reproductive options, including prenatal diagnosis and preimplantation genetic testing, that can prevent an affected parent from having a child with the genetic predisposition. Owing to the complex genetic architecture of cardiac diseases, characterized by incomplete disease penetrance and the interplay between monogenic and polygenic variants, the risk reduction that can be achieved using reproductive genetic testing varies among individuals. Globally, disparities, including regulatory and financial barriers, in access to reproductive genetic tests exist. Although reproductive options are gaining a prominent position in the management of patients with inherited cardiac diseases, specific policies and guidance are lacking. Guidelines recommend that prenatal diagnosis and preimplantation genetic testing are options that should be discussed with families. Health-care professionals should, therefore, be aware of the possibilities and feel confident to discuss the benefits and challenges. In this Review, we provide an overview of the reproductive options in the context of inherited cardiac diseases, covering the genetic, technical, psychosocial and equity considerations, to prepare health-care professionals for discussions with their patients.</p>","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"53 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal haematopoiesis: an emerging causal risk factor for atherosclerotic CVD 克隆性造血：动脉粥样硬化性心血管疾病的新致病风险因素
IF 41.7 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01081-3
Jennifer Harman
{"title":"Clonal haematopoiesis: an emerging causal risk factor for atherosclerotic CVD","authors":"Jennifer Harman","doi":"10.1038/s41569-024-01081-3","DOIUrl":"10.1038/s41569-024-01081-3","url":null,"abstract":"New research suggests that the presence of clonal haematopoiesis is unidirectionally associated with the development of atherosclerosis and that colchicine holds potential therapeutic value.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 11","pages":"741-741"},"PeriodicalIF":41.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gut microbiota in thrombosis 血栓形成中的肠道微生物群
IF 49.6 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01070-6
My Phung Khuu, Nadja Paeslack, Olga Dremova, Corinne Benakis, Klytaimnistra Kiouptsi, Christoph Reinhardt
{"title":"The gut microbiota in thrombosis","authors":"My Phung Khuu, Nadja Paeslack, Olga Dremova, Corinne Benakis, Klytaimnistra Kiouptsi, Christoph Reinhardt","doi":"10.1038/s41569-024-01070-6","DOIUrl":"https://doi.org/10.1038/s41569-024-01070-6","url":null,"abstract":"<p>The gut microbiota has emerged as an environmental risk factor that affects thrombotic phenotypes in several cardiovascular diseases. Evidence includes the identification of marker species by sequencing studies of the gut microbiomes of patients with thrombotic disease, the influence of antithrombotic therapies on gut microbial diversity, and preclinical studies in mouse models of thrombosis that have demonstrated the functional effects of the gut microbiota on vascular inflammatory phenotypes and thrombus formation. In addition to impaired gut barrier function promoting low-grade inflammation, gut microbiota-derived metabolites have been shown to act on vascular cell types and promote thrombus formation. Therefore, these meta-organismal pathways that link the metabolic capacities of gut microorganisms with host immune functions have emerged as potential diagnostic markers and novel drug targets. In this Review, we discuss the link between the gut microbiota, its metabolites and thromboembolic diseases.</p>","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"36 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interferon response at the border zone of the infarcted heart 梗死心脏边界区的干扰素反应
IF 41.7 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-17 DOI: 10.1038/s41569-024-01078-y
Karina Huynh
{"title":"Interferon response at the border zone of the infarcted heart","authors":"Karina Huynh","doi":"10.1038/s41569-024-01078-y","DOIUrl":"10.1038/s41569-024-01078-y","url":null,"abstract":"Cardiomyocytes can activate the type I interferon response in the infarct border zone after myocardial infarction, indicating that the type I interferon pathway, in addition to its well-established role in antiviral responses, is also involved in cardiac injury.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 11","pages":"740-740"},"PeriodicalIF":41.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential roles of eosinophils in cardiovascular disease 嗜酸性粒细胞在心血管疾病中的不同作用
IF 49.6 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-16 DOI: 10.1038/s41569-024-01071-5
Junyan Xu, Junli Guo, Tianxiao Liu, Chongzhe Yang, Zhaojie Meng, Peter Libby, Jinying Zhang, Guo-Ping Shi
{"title":"Differential roles of eosinophils in cardiovascular disease","authors":"Junyan Xu, Junli Guo, Tianxiao Liu, Chongzhe Yang, Zhaojie Meng, Peter Libby, Jinying Zhang, Guo-Ping Shi","doi":"10.1038/s41569-024-01071-5","DOIUrl":"https://doi.org/10.1038/s41569-024-01071-5","url":null,"abstract":"<p>Eosinophils are essential innate immune cells in allergic responses. Accumulating evidence indicates that eosinophils also participate in the pathogenesis of cardiovascular diseases (CVDs). In clinical studies, high blood eosinophil counts and eosinophil cationic protein levels have been associated with an increased risk of CVD, including myocardial infarction (MI), cardiac hypertrophy, atrial fibrillation, abdominal aortic aneurysm (AAA) and atherosclerosis. However, low blood eosinophil counts have also been reported to be a risk factor for MI, heart failure, aortic dissection, AAA, deep vein thrombosis, pulmonary embolism and ischaemic stroke. Although these conflicting clinical observations remain unexplained, CVD status, timing of eosinophil data collection, and tissue eosinophil phenotypic and functional heterogeneities might account for these discrepancies. Preclinical studies suggest that eosinophils have protective actions in MI, cardiac hypertrophy, heart failure and AAA. By contrast, cationic proteins and platelet-activating factor from eosinophils have been shown to promote vascular smooth muscle cell proliferation, vascular calcification, thrombomodulin inactivation and platelet activation and aggregation, thereby exacerbating atherosclerosis, atrial fibrillation, thrombosis and associated complications. Therefore, eosinophils seem to promote calcification and thrombosis in chronic CVD but are protective in acute cardiovascular settings. In this Review, we summarize the available clinical and preclinical data on the different roles of eosinophils in CVD.</p>","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"5 1","pages":""},"PeriodicalIF":49.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142235051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atheroimmunology: keeping the immune system in atherosclerosis in check 动脉粥样硬化免疫学：控制动脉粥样硬化的免疫系统
IF 41.7 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-11 DOI: 10.1038/s41569-024-01075-1
Claudia Monaco, Lea Dib
{"title":"Atheroimmunology: keeping the immune system in atherosclerosis in check","authors":"Claudia Monaco,&nbsp;Lea Dib","doi":"10.1038/s41569-024-01075-1","DOIUrl":"10.1038/s41569-024-01075-1","url":null,"abstract":"The immune response is not unlike a game of chess, with white and black pieces playing opposing roles and orchestrating an opening, a middle and an endgame of innate immunity, adaptive immunity and resolution, respectively. After decades of research, the study of atheroimmunology has brought the first therapeutics to the clinic. Can we resynchronize the immune system in atherosclerosis and save the king?","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"21 11","pages":"737-738"},"PeriodicalIF":41.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Over US$100 million pledged to improve cancer care across Africa. 认捐 1 亿多美元，用于改善非洲各地的癌症治疗。
IF 41.6 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-01 Epub Date: 2024-07-25 DOI: 10.1016/S1470-2045(24)00433-9
Paul Adepoju
{"title":"Over US$100 million pledged to improve cancer care across Africa.","authors":"Paul Adepoju","doi":"10.1016/S1470-2045(24)00433-9","DOIUrl":"10.1016/S1470-2045(24)00433-9","url":null,"abstract":"","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":" ","pages":"1119"},"PeriodicalIF":41.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of PROMISE criteria on PSMA-PET for prediction of overall survival in prostate cancer. 使用 PSMA-PET 的 PROMISE 标准预测前列腺癌患者的总生存期。
IF 41.6 1区 农林科学
Journal of Agricultural and Food Chemistry Pub Date : 2024-09-01 Epub Date: 2024-07-29 DOI: 10.1016/S1470-2045(24)00339-5
Kirsten Bouchelouche, Peter L Choyke
{"title":"Use of PROMISE criteria on PSMA-PET for prediction of overall survival in prostate cancer.","authors":"Kirsten Bouchelouche, Peter L Choyke","doi":"10.1016/S1470-2045(24)00339-5","DOIUrl":"10.1016/S1470-2045(24)00339-5","url":null,"abstract":"","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":" ","pages":"1107-1108"},"PeriodicalIF":41.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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