Journal of Agricultural and Food Chemistry最新文献_第10页

Quercetin Ameliorates Cognitive Impairment in Obese Mice by Activating the PI3K/AKT/GSK3β Signaling Pathway via the Microbiota–Gut–Brain Axis 槲皮素通过微生物-肠-脑轴激活PI3K/AKT/GSK3β信号通路改善肥胖认知障碍

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-10-02 DOI: 10.1021/acs.jafc.6c04686

Wenxuan Li, Yanping Pei, Junteng Wang, Jiayi Zhang, Wenyuan Zhang, Xiaoyu Jiang, Qingxu Zhao, Hui Liu, Hang Xiao, Dapeng Li

{"title":"Quercetin Ameliorates Cognitive Impairment in Obese Mice by Activating the PI3K/AKT/GSK3β Signaling Pathway via the Microbiota–Gut–Brain Axis","authors":"Wenxuan Li, Yanping Pei, Junteng Wang, Jiayi Zhang, Wenyuan Zhang, Xiaoyu Jiang, Qingxu Zhao, Hui Liu, Hang Xiao, Dapeng Li","doi":"10.1021/acs.jafc.6c04686","DOIUrl":"10.1021/acs.jafc.6c04686","url":null,"abstract":"Obesity and its associated insulin resistance are importantriskfactors for cognitive impairment. In this study, a 10-week C57BL/6mouse model was established to investigate the effects of dietaryquercetin supplementation at 0.05% (w/w) on HFFD-induced obesity-relatedcognitive impairment. The results showed that quercetin significantlyreduced HFFD-induced body weight gain (P < 0.05)and improved serum lipid abnormalities and cognitive performance.Integrated multi-omics analysis further revealed that quercetin reshapedthe gut microbiota composition, notably increasing Akkermansia muciniphila, restored intestinal barrierfunction, and regulated serum metabolite profiles. These alterationssubsequently suppressed neuroinflammation, activated the hippocampalPI3K/AKT/GSK3β signaling pathway (with increases of 46%, 49%,and 50% in p-PI3K, p-Akt, and p-GSK-3β expression, respectively), and inhibitedabnormal tau phosphorylation and neuronal apoptosis. The novelty ofthis study lies in constructing an integrated regulatory axis linkingdietary quercetin, gut microbiota, serum metabolites, and hippocampalinsulin signaling, providing novel mechanistic insights into quercetinin neuro-metabolic diseases.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31601–31615"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The FgSdhAF2–FgSdhA Interface asa Potential Novel Antifungal Target in Fusarium graminearum : Genetic Characterization and Structure-Based Inhibitor Discovery fgshaf2 - fgsdha界面是谷草镰刀菌潜在的新型抗真菌靶点：遗传表征和基于结构的抑制剂发现

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 DOI: 10.1021/acs.jafc.6c11869

XiuJuan Li,Bin Chen,Wenchan Chen,Wei Wang,Siqi Yao,Hao hu,Shuzhou Liu,Guo Li,Jiawei Li,Xiushi Song,Wenyong Shao,Changjun Chen

{"title":"The FgSdhAF2–FgSdhA Interface as\u0000a Potential Novel Antifungal Target in\u0000 Fusarium graminearum\u0000 : Genetic Characterization and Structure-Based Inhibitor Discovery","authors":"XiuJuan Li,Bin Chen,Wenchan Chen,Wei Wang,Siqi Yao,Hao hu,Shuzhou Liu,Guo Li,Jiawei Li,Xiushi Song,Wenyong Shao,Changjun Chen","doi":"10.1021/acs.jafc.6c11869","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c11869","url":null,"abstract":"Abstract Fusarium graminearum causes Fusarium head blight and threatens cereal production through deoxynivalenol (DON) contamination. The biological role of FgSdhAF2 was characterized, and a potential antifungal pocket adjacent to the FgSdhAF2–FgSdhA interface was identified. Deletion of FgSdhAF2 markedly reduced mycelial growth, conidiation, virulence, DON production, and FgTri5 expression in SDHI-sensitive PH-1 and intrinsically resistant G1. The FgSdhAF2 E159Y substitution similarly reduced mycelial growth, conidiation, and virulence. Using this predicted pocket for structure-based virtual screening, approximately 1.6 million compounds were screened, yielding ten candidates. Compound 156758 inhibited PH-1, G1, and the highly pydiflumetofen-resistant FgSdhC1A83 V mutant, with EC50 values of 3.33–3.59 μg/mL, and reduced DON accumulation by 53.9–55.4%. It also showed broad-spectrum activity against eight additional phytopathogenic fungi. Collectively, these findings support this predicted interface as a potential antifungal target and 156758 as a lead compound for developing fungicides to manage SDHI-resistant F. graminearum populations.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"32 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Bioinspired, Photostable, Rain-Resilient Zein-Polyphenol-Based Nanocomposite with Enhanced Pesticidal Activity for Sustainable Agrochemical Delivery 一种生物启发的、光稳定的、耐雨的玉米多酚基纳米复合材料，具有增强的农药活性，用于可持续的农用化学品输送

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-09-23 DOI: 10.1021/acs.jafc.6c07146

Nikita Shraogi, Joel Saji, Chitrita Chakraborty, Amrita Singh, Saurabh Singh, Kavita Krishna, Shriza Rai, Sadasivam Anbumani, Geetanjali Mishra, Praveen Chandra Verma, Debabrata Ghosh, Satyakam Patnaik

{"title":"A Bioinspired, Photostable, Rain-Resilient Zein-Polyphenol-Based Nanocomposite with Enhanced Pesticidal Activity for Sustainable Agrochemical Delivery","authors":"Nikita Shraogi, Joel Saji, Chitrita Chakraborty, Amrita Singh, Saurabh Singh, Kavita Krishna, Shriza Rai, Sadasivam Anbumani, Geetanjali Mishra, Praveen Chandra Verma, Debabrata Ghosh, Satyakam Patnaik","doi":"10.1021/acs.jafc.6c07146","DOIUrl":"10.1021/acs.jafc.6c07146","url":null,"abstract":"Conventionalpesticide formulations suffer from poor foliage retention,rapid photodegradation, and the need for repeated applications, therebyreducing field efficacy and increasing environmental burden. Herein,we designed a water-dispersible, bioinspired nanopesticide (IND@PLA@PZTA)by coating indoxacarb-loaded poly(lactic acid) nanoparticles witha phosphorylated zein–tannic acid coating. The formulationachieved 96.3% encapsulation efficacy and sustained pesticide releasefor 96 h while exhibiting improved wettability, foliage retention,and enhanced UV protection, retaining 72% of the pesticide after 3h of UV exposure. Against Spodoptera litura, the nanopesticides produced 96.7% larval mortality after 56 h,representing a 2.6-fold improvement over the commercial formulation,and effectively suppressed larval development. A greenhouse studyfurther validated these results. Moreover, the nanoformulation alsoshowed reduced toxicity toward nontarget organisms, including ladybirds,soil bacteria, Daphnia magna, Vigna radiata and human keratinocytes. Constructedentirely from Generally Recognized as Safe (GRAS) materials, thismultifunctional nanopesticide represents a sustainable strategy forpesticide delivery.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31429–31443"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of the Biosynthesis of Phenolic Compounds in Vaccinium Berries 枸杞酚类化合物生物合成的调控

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-09-25 DOI: 10.1021/acs.jafc.6c08282

Laura Jaakola

引用次数: 0

Food-Specific Challenges and Stabilization Strategies for Replacing Synthetic Pigments with Natural Pigments 用天然色素替代合成色素的食品特异性挑战和稳定策略

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-10-03 DOI: 10.1021/acs.jafc.6c07521

Kefan Ouyang, Yanyan Zhang, Shuangjian Li, Saiya Li, Yapeng Fang, Yiping Cao

{"title":"Food-Specific Challenges and Stabilization Strategies for Replacing Synthetic Pigments with Natural Pigments","authors":"Kefan Ouyang, Yanyan Zhang, Shuangjian Li, Saiya Li, Yapeng Fang, Yiping Cao","doi":"10.1021/acs.jafc.6c07521","DOIUrl":"10.1021/acs.jafc.6c07521","url":null,"abstract":"Driven by regulatory restrictions,clean-label trends,and healthconcerns, the food industry is transitioning from synthetic to naturalcolorants. This review analyzes this transformation, first outliningkey drivers reshaping the food coloring landscape. It then evaluatespigment applications across major food categories (soft drinks, confectionery,bakery, dairy, and meat/analogues), highlighting food-specific technicalchallenges rooted in the inherent instability of natural pigments.Central to this review is an in-depth examination of the mechanismsunderlying pigment degradation under environmental stresses (heat,light, pH, oxygen, metal ions, and enzymatic reactions). In response,we critically evaluate emerging strategies to enhance pigment stability,spanning improved encapsulation techniques to AI-assisted formulationdesign, alongside alternative coloring pathways such as structuralcolor. Advancing synthetic pigment replacement demands shifting fromgeneric approaches to food-specific customization, simplified testingto high-fidelity evaluation, and isolated development to integratedassessments of safety, sensory quality, and economic viability.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31305–31320"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Scanning Calorimetry Quantification of Folded Whey Proteins in Infant Formula 差示扫描量热法定量测定婴儿配方奶粉中折叠乳清蛋白

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-10-02 DOI: 10.1021/acs.jafc.6c11376

Joy C. Devenport, Jackson Tower, Charity C. Jennings, Grace H. Davis, Jason D. Kenealey

引用次数: 0

Tungsten in Agricultural Soil Triggers Coordinated Bioenergetic Responses and Gut Microbiome Dysbiosis in Earthworms: Implications for Agricultural Soil Health 农业土壤中的钨触发协调的生物能量反应和蚯蚓肠道微生物群失调：对农业土壤健康的影响

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-10-01 DOI: 10.1021/acs.jafc.6c10283

Shuai Li, Chunyu Yang, Aohan Dai, Xiao Yang, Zhongkun Du, Yaoyu Zhou, Ming Lei, Huihui Du

{"title":"Tungsten in Agricultural Soil Triggers Coordinated Bioenergetic Responses and Gut Microbiome Dysbiosis in Earthworms: Implications for Agricultural Soil Health","authors":"Shuai Li, Chunyu Yang, Aohan Dai, Xiao Yang, Zhongkun Du, Yaoyu Zhou, Ming Lei, Huihui Du","doi":"10.1021/acs.jafc.6c10283","DOIUrl":"10.1021/acs.jafc.6c10283","url":null,"abstract":"Tungsten (W) can accumulate in agriculturalsoils nearmining,smelting, industrial, and waste-disposal sites, yet its chronic effectson beneficial soil fauna remain poorly understood. Eisenia fetida were exposed for 28 d to soil W concentrations selectedwith reference to agricultural contamination and toxicity assessment.Despite minimal mortality, W caused concentration-dependent growthinhibition and pronounced reproductive toxicity, with cocoon productiondeclining by 76.4% at 700 mg kg–1 and being completelyinhibited at 1500 mg kg–1. Integrated biochemical,histopathological, transcriptomic, metabolomic, and gut microbiomeanalyses revealed coordinated responses centered on bioenergetic constraint.Internal W accumulation disrupted redox homeostasis, glutathione-dependentdetoxification, mitochondrial energy metabolism, and sulfur metabolism,resulting in ATP depletion, Ca2+ dysregulation, acetylcholinesteraseinhibition, and tissue injury. W also induced marked gut microbiomedysbiosis. Procrustes and DIABLO analyses supported coordinated responsesacross omics layers. These findings support a proposed mechanisticframework in which bioenergetic constraint represents an importantcomponent of W-associated physiological dysfunction and reproductiveimpairment in earthworms.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31527–31540"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of a trans-Configured Monofluoroalkene as a Potent Succinate Dehydrogenase Inhibitor against Phakopsora pachyrhizi 一种反式构型单氟烯酮是一种有效的琥珀酸脱氢酶抑制剂

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-09-29 DOI: 10.1021/acs.jafc.6c02371

Letian Zhang, Yuchen Li, Wende Wu, Zhong Li, Xiaoyong Xu

{"title":"Discovery of a trans-Configured Monofluoroalkene as a Potent Succinate Dehydrogenase Inhibitor against Phakopsora pachyrhizi","authors":"Letian Zhang, Yuchen Li, Wende Wu, Zhong Li, Xiaoyong Xu","doi":"10.1021/acs.jafc.6c02371","DOIUrl":"10.1021/acs.jafc.6c02371","url":null,"abstract":"A series of monofluoroalkene derivatives were designedand synthesizedas succinate dehydrogenase inhibitors (SDHIs). Most compounds showedhigh in vitro activity against Rhizoctonia solani, with EC50 values below 0.01 mg/L.Compound V-17b (4-OPh) was the most potent (EC50 = 0.0029 mg/L), surpassing boscalid and fluxapyroxad by over 10-fold.Several compounds retained >50% inhibition in vivo at 200 mg/L against Rhizoctonia solani. Compound V-6b exhibited 100% efficacy against Phakopsora pachyrhizi at 1 mg/L, and V-9b showed 77.8% and 96.3% efficacy against Puccinia glumarum and Puccinia sorghi at 10 mg/L, respectively. Enzyme assays revealed that V-9b inhibited porcine SDH (IC50 = 1.87 μM) more effectivelythan fluxapyroxad (IC50 = 8.13 μM), with the trans isomer superior to the cis. Moleculardocking indicated that the trans configuration enablesadditional π–π stacking with Trp_B173. These resultsdemonstrate that the monofluoroalkene scaffold, combined with appropriatesubstitution patterns and configuration, can generate potent SDHIswith promising fungicidal profiles.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31329–31342"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Vitamin K2 Isoforms Restore Redox Balance, Organelle Integrity, and Genomic Stability under Streptozotocin-Induced Oxidative Stress in Differentiated SH-SY5Y Cells 膳食维生素ink2异构体在链脲佐菌素诱导的氧化应激下恢复SH-SY5Y细胞氧化还原平衡、细胞器完整性和基因组稳定性

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-10-05 DOI: 10.1021/acs.jafc.6c03233

Shruti Shandilya, Janne Ruokolainen

{"title":"Dietary Vitamin K2 Isoforms Restore Redox Balance, Organelle Integrity, and Genomic Stability under Streptozotocin-Induced Oxidative Stress in Differentiated SH-SY5Y Cells","authors":"Shruti Shandilya, Janne Ruokolainen","doi":"10.1021/acs.jafc.6c03233","DOIUrl":"10.1021/acs.jafc.6c03233","url":null,"abstract":"Among the two dietary vitamin K2 isoforms, MK-4 is abundantlyfoundin the brain, and MK-7 is well absorbed and has a longer half-life.Beyond canonical functions, these dietary vitamin K2 vitamers haveemerged as bioactive nutrients with potential cytoprotective properties.However, their presence in the brain and their functional relevancein modulating oxidative-stress-associated organelle damage, genomicinstability, and neurite integrity remain insufficiently characterized.Streptozotocin led to impaired cellular bioenergetics, followed byorganelle damage and genotoxicity. Post-treatment with MK-4 and MK-7significantly attenuated ROS accumulation, enhanced antioxidant capacity,and preserved mitochondrial functional integrity, as evidenced byimproved mitochondrial footprint, reduced mitochondrial ROS, restoredATP levels, and regulated mitophagy. Furthermore, vitamin K2 isoformsmitigated endoplasmic reticulum/Golgi stress, significantly reducedDNA damage, and improved neurite growth. Thus, vitamin K2 isoformsfunction as multifunctional dietary bioactive compounds with potentialrelevance for maintaining cell homeostasis during oxidative-stress-associatedneuronal dysfunction.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31583–31600"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Comparative Genomics and Structuromics Uncover Functional Adaptations and Conserved Autophagy in Three Pleurotus Species 综合比较基因组学和结构组学研究：三种侧耳菌的功能适应和保守自噬

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-10-02 DOI: 10.1021/acs.jafc.6c05445

Peng Wang, Linhai Hong, Xumin Li, Shuhong Li, Qinghong Liu

{"title":"Integrated Comparative Genomics and Structuromics Uncover Functional Adaptations and Conserved Autophagy in Three Pleurotus Species","authors":"Peng Wang, Linhai Hong, Xumin Li, Shuhong Li, Qinghong Liu","doi":"10.1021/acs.jafc.6c05445","DOIUrl":"10.1021/acs.jafc.6c05445","url":null,"abstract":"Thegenus Pleurotus comprises economically importantedible fungi with diverse ecological adaptations, yet the molecularbasis of their functional diversity remains unclear. Comparative genomicsof three Pleurotus species (Pleurotus ostreatus, Pleurotus citrinopileatus, Pleurotus salmoneostramineus) revealedspecies-specific gene expansions: reproduction/cell cycle in P. ostreatus, secondary metabolism in P. citrinopileatus, and amino acid/protein metabolismin P. salmoneostramineus. Laccase genesvaried markedly in number and sequence, whereas chitin synthases weremore conserved. Autophagy-related genes (17, 16, and 15, respectively)were identified. Structuromics uncovered species-specific secondarystructures of laccases and chitin synthase dimer interfaces, whichmay reflect structural variations potentially linked to their distinctthermal niches. Remarkably, core ATG protein complexes exhibited highlyconserved tertiary structures and interaction interfaces, with subtlemodifications in ATG9 trimers. Comparative structuromics thus complementsgenomics by showing how structural variation in growth-related genesmay underlie environmental plasticity, while also speculating thedeep functional conservation of core machineries.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31916–31950"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0