人参皂苷Rk2通过改善肠道屏障功能，重塑肠道微生物群，调节Th17/Treg平衡，提供溃疡性结肠炎的多维缓解

IF 6.2 1区农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY

Journal of Agricultural and Food Chemistry Pub Date : 2025-09-24 DOI:10.1021/acs.jafc.5c04210

Luying Tan, Zhuoqiao Li, Junzhe Wu, Hanlin Liu, Ting Yang, Jia Wang, Linxuan Liu, Xiaoyu Geng, Jinping Liu

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引用次数: 0

摘要

溃疡性结肠炎（UC）是一种多因素炎症性肠病，与肠屏障完整性、肠道微生物群和免疫稳态有关。根据以往的研究，人参皂苷Rk2 （Rk2）在Caco-2和THP-1细胞共培养中表现出抗炎活性。这项研究首次证明了Rk2通过调节“屏障-微生物-免疫”轴对UC产生积极影响。Rk2不仅可以改善炎症因子水平和结肠炎症状，还可以通过增加经上皮电阻（TEER）值和提高紧密连接蛋白的表达来增强肠上皮屏障功能，通过丰富肠道微生物群的多样性和组成、增加短链脂肪酸（SCFAs）水平来重塑肠道微生物群，通过恢复Th17/Treg平衡来维持肠道内稳态。此外，Rk2对UC的影响可能通过TNFSF14/LTβR/NIK途径介导。综上所述，Rk2通过多维调控对UC发挥有益作用，是UC潜在的天然治疗剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ginsenoside Rk2 Provides Multidimensional Relief for Ulcerative Colitis by Improving Intestinal Barrier Function, Reshaping Gut Microbiota, and Regulating Th17/Treg Balance

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Ginsenoside Rk2 Provides Multidimensional Relief for Ulcerative Colitis by Improving Intestinal Barrier Function, Reshaping Gut Microbiota, and Regulating Th17/Treg Balance

Ulcerative colitis (UC) is a multifactorial inflammatory bowel disease associated with intestinal barrier integrity, gut microbiota, and immune homeostasis. According to previous studies, ginsenoside Rk2 (Rk2) demonstrated anti-inflammatory activity in cocultures of Caco-2 and THP-1 cells. This study was the first to demonstrate that Rk2 positively impacted UC by regulating the “barrier-microbiota-immune” axis. Rk2 not only improved inflammatory factor levels and colitis symptoms but also enhanced intestinal epithelial barrier function via increased transepithelial electrical resistance (TEER) values and elevated expressions of tight junction proteins, remodeled gut microbiota via enriching its diversity and composition and increasing short-chain fatty acids (SCFAs) levels, and maintained intestinal homeostasis via restoring Th17/Treg balance. Moreover, the influence of Rk2 on UC might be mediated via the TNFSF14/LTβR/NIK pathway. In summary, Rk2 exerted a beneficial effect on UC by providing multidimensional regulation and was a potential natural therapeutic agent for UC.

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来源期刊

Journal of Agricultural and Food Chemistry 农林科学-农业综合

CiteScore

9.90

自引率

8.20%

发文量

1375

审稿时长

2.3 months

期刊介绍： The Journal of Agricultural and Food Chemistry publishes high-quality, cutting edge original research representing complete studies and research advances dealing with the chemistry and biochemistry of agriculture and food. The Journal also encourages papers with chemistry and/or biochemistry as a major component combined with biological/sensory/nutritional/toxicological evaluation related to agriculture and/or food.