Journal of Agricultural and Food Chemistry最新文献_第7页

A Paeoniae RadixAlba Polysaccharide Fraction BP-1Restores Intestinal Barrier Function and Gut Microbiota–MetabolicHomeostasis in Collagen-Induced Arthritis Rats 白芍多糖bp -1对胶原诱导关节炎大鼠肠道屏障功能和肠道微生物代谢稳态的恢复作用

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-15 DOI: 10.1021/acs.jafc.6c06645

Yongchun Wang,Yongxi Wu,Yuhan Xie,Qiulu Zhao,Jianing Liu,Meihua Jiang,Yinlu Zhang,Songyang Xia,Wenshuo Zhang,Hao Yue,Zifeng Pi

{"title":"A Paeoniae Radix\u0000Alba Polysaccharide Fraction BP-1\u0000Restores Intestinal Barrier Function and Gut Microbiota–Metabolic\u0000Homeostasis in Collagen-Induced Arthritis Rats","authors":"Yongchun Wang,Yongxi Wu,Yuhan Xie,Qiulu Zhao,Jianing Liu,Meihua Jiang,Yinlu Zhang,Songyang Xia,Wenshuo Zhang,Hao Yue,Zifeng Pi","doi":"10.1021/acs.jafc.6c06645","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c06645","url":null,"abstract":"Abstract Paeoniae Radix Alba (PRA) polysaccharides are promising food-derived bioactives, yet their gut-mediated effects on rheumatoid arthritis (RA) remain unclear. Here, BP-1 was purified, structurally characterized, and evaluated in collagen-induced arthritis (CIA) rats and lipopolysaccharide (LPS)-injured Caco-2 cells. BP-1 was a 14.124 kDa neutral polysaccharide mainly composed of glucose and mannose. NMR analysis identified →4)-α-D-Glcp-(1→, →4,6)-α-D-Glcp-(1→, α-T-D-Glcp-(1→, →4,6)-β-D-Manp-(1→, and α-T-D-Galp-(1→ residues. BP-1 alleviated arthritis severity, joint pathology, systemic inflammation, and colonic injury, while improving intestinal barrier integrity in vivo and in vitro. These effects were potentially associated with suppression of TLR4/MyD88/NF-κB signaling, restoration of immune homeostasis, and modulation of gut microbiota and fecal metabolites. These findings support BP-1 as a potential functional food ingredient for inflammation-associated intestinal and immune disorders.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"20 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Rhizobial TypeIII Effector NopD Regulates the GmPP2C-ENOD93 Axisto Control Symbiotic Nodulation and Yieldin Soybean 根瘤菌iii型效应物NopD调控GmPP2C-ENOD93轴对称调控大豆共生结瘤和产量

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-15 DOI: 10.1021/acs.jafc.6c07326

Liang Mi,Liying Lu,Jiake Sun,Yansong Li,Chao Ma,Shengnan Ma,Mingliang Yang,Siyan Hong,Miao Wang,Lin Chen,Chunyan Liu,Dawei Xin,Qingshan Chen,Jinhui Wang

{"title":"The Rhizobial Type\u0000III Effector NopD Regulates the\u0000 GmPP2C-ENOD93\u0000 Axis\u0000to Control Symbiotic Nodulation and Yield\u0000in Soybean","authors":"Liang Mi,Liying Lu,Jiake Sun,Yansong Li,Chao Ma,Shengnan Ma,Mingliang Yang,Siyan Hong,Miao Wang,Lin Chen,Chunyan Liu,Dawei Xin,Qingshan Chen,Jinhui Wang","doi":"10.1021/acs.jafc.6c07326","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c07326","url":null,"abstract":"Abstract Type III effector proteins (T3Es) are pivotal orchestrators of host–microbe interactions and essential for establishing symbiosis, thereby influencing soybean growth and productivity through modulation of symbiotic nitrogen fixation (SNF). While the central role of the T3E NopD in soybean SNF is recognized, its mechanistic underpinnings have remained elusive. In this study, we determined that GmPP2C, whose expression is regulated by NopD, serves as a regulator of nodulation. Overexpression of GmPP2C suppressed infection-thread formation and markedly reduced nodule number, whereas CRISPR/Cas9-mediated disruption enhanced infection events and partially rescued nodulation defects of NopD deficiency. Transcriptome profiling and complementation assays indicate GmPP2C inhibits nodulation by repressing ENOD93. Loss of GmPP2C increased per-plant yield without altering plant architecture or seed quality. These findings delineate the NopD–GmPP2C–ENOD93 regulatory module governing soybean nodulation and pinpoint GmPP2C as a compelling target for molecular breeding to enhance nitrogen-fixation efficiency and bolster crop yields.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"68 1 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ ActiveSite-Engineered Z-Scheme CMCN/Co3O4-ZIF-8Heterostructure for EfficientTetracycline Degradation CMCN/ co3o4 - zif -8异质结构对四环素的有效降解

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-15 DOI: 10.1021/acs.jafc.6c09760

Wen Hao,Xueyan Cui,Lin Cai,Yichuan Cao,Guozhen Fang,Shuo Wang

{"title":"In Situ Active\u0000Site-Engineered Z-Scheme CMCN/Co3O4-ZIF-8\u0000Heterostructure for Efficient\u0000Tetracycline Degradation","authors":"Wen Hao,Xueyan Cui,Lin Cai,Yichuan Cao,Guozhen Fang,Shuo Wang","doi":"10.1021/acs.jafc.6c09760","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c09760","url":null,"abstract":"Abstract Antibiotic contamination poses environmental risks and requires efficient degradation technologies. Herein, a Z-scheme heterostructured photocatalyst (CMCN/Co3O4-ZIF-8) was constructed by thermally coupling precursor-modified graphitic carbon nitride (CMCN) with metal–organic framework (MOF) derivative (Co3O4-ZIF-8) for tetracycline degradation. Temperature-regulated pyrolysis of ZnCo-MOF afforded Co3O4-ZIF-8 with in situ-formed Co3O4 active sites and a porous framework. CMCN/Co3O4-ZIF-8 heterointerface promoted charge separation and migration via interfacial electric field and energy gradient, enabling Z-scheme charge-transfer pathway that retained highly reductive electrons on Co3O4-ZIF-8 and strongly oxidative holes on CMCN. The Co2+/Co3+ redox cycle in Co3O4-ZIF-8 further facilitated interfacial electron transfer and O2 activation. Superoxide radicals and oxidative holes participated in tetracycline degradation, achieving a degradation efficiency of 86.88%. LC-MS analysis revealed major tetracycline degradation pathways, and toxicity evaluation indicated reduced toxicity of most intermediates. This study guided catalyst design by integrating in situ active site formation and Z-scheme charge-transfer pathway for antibiotic removal.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"482 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic EngineeringStrategies for Rare d -Allulose Production from d -Glucose– d -Xylose Mixtures Using Escherichia coli 利用大肠杆菌从d -葡萄糖- d -木糖混合物中生产稀有丙烯醛的代谢工程策略

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-15 DOI: 10.1021/acs.jafc.6c01629

Zheng-Sheng Shi,Ling Shi,Ling-Jie Zheng,Huidong Zheng,Qiang Guo,Li-Hai Fan

{"title":"Metabolic Engineering\u0000Strategies for Rare\u0000 d\u0000 -Allulose Production from\u0000 d\u0000 -Glucose–\u0000 d\u0000 -Xylose Mixtures Using\u0000 Escherichia coli","authors":"Zheng-Sheng Shi,Ling Shi,Ling-Jie Zheng,Huidong Zheng,Qiang Guo,Li-Hai Fan","doi":"10.1021/acs.jafc.6c01629","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c01629","url":null,"abstract":"Abstract d-Allulose is a functional sweetener with tremendous potential in food and health industries. Recent studies of its biosynthesis have mainly focused on enzyme catalysis or microbial fermentation using single-sugar substrates. Herein, we constructed a cell factory that coutilizes d-glucose and d-xylose for the efficient biosynthesis of d-allulose. Specifically, the expression of key enzymes in the synthesis pathway, along with the knockout of PtsG, ensured the simultaneous conversion of both sugars to d-allulose. By inactivating PfkA and PfkB and inhibiting Zwf expression, carbon flux from the Embden–Meyerhof–Parnas and pentose phosphate pathways was redirected toward the synthesis pathway. A transhydrogenase cycle was introduced to optimize the cofactor supply, while byproduct pathways were blocked to prevent product loss. Finally, the functionality of the engineered Escherichia coli was confirmed through shake-flask fermentation using wheat straw hydrolysate as the substrate, achieving a titer of 3.33 g/L and a yield of 0.226 g/g.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"16 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel ModificationsΔI127/L85R in FsSdhD AreInvolved in Differential Resistance to Pydiflumetofen in Fusarium solani 新基因ModificationsΔI127/L85R参与了茄枯菌对嘧螨醚的抗性差异

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-15 DOI: 10.1021/acs.jafc.6c08392

Lingling Wei,Liguo Tan,Weimeng Huang,Yinhong Liu,Lu Ren,Xiaojun Zhao

引用次数: 0

Transcriptomicand Metabolomic Analyses Provide Insightsinto the Effects of Dietary Nanoselenium on Translucent Egg Formationin Laying Hens 转录组学和代谢组学分析揭示了饲粮中纳米硒对蛋鸡半透明蛋形成的影响

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-15 DOI: 10.1021/acs.jafc.6c07804

Haojie Gong,Xuemei Ding,Shiping Bai,Keying Zhang,Qiufeng Zeng,Yan Liu,Xiangbing Mao,Jianping Wang

{"title":"Transcriptomic\u0000and Metabolomic Analyses Provide Insights\u0000into the Effects of Dietary Nanoselenium on Translucent Egg Formation\u0000in Laying Hens","authors":"Haojie Gong,Xuemei Ding,Shiping Bai,Keying Zhang,Qiufeng Zeng,Yan Liu,Xiangbing Mao,Jianping Wang","doi":"10.1021/acs.jafc.6c07804","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c07804","url":null,"abstract":"Abstract Eggshell translucency is a common eggshell defect characterized by water-mark-like spots visible to the naked eye under natural light, which can negatively affect consumer acceptance and the market value of eggs. Nanoselenium (Nano-Se) is a novel selenium form with the potential to improve egg quality. In this study, the translucent egg formation and the effects of nano-Se supplementation were investigated using transcriptomic and metabolomic analyses. Translucent eggs showed a higher moisture content and lower eggshell calcium content, along with a thicker and looser mammillary layer and reduced eggshell membrane crude protein and essential amino acid (EAA) contents. Dietary nano-Se reduced translucent egg formation and eggshell moisture, improved egg freshness and mammillary ultrastructure, and altered eggshell membrane amino acid profiles. Transcriptomic analysis revealed the enrichment of calcium signaling- and oxidative phosphorylation-related pathways, while metabolomic analysis highlighted alterations in amino acid biosynthesis and metabolism. Overall, dietary Nano-Se reduced translucent egg formation, accompanied by improved eggshell ultrastructure, reduced eggshell moisture accumulation, and altered eggshell membrane amino acid profiles, which were associated with changes in uterine calcium transport, antioxidant capacity, and amino acid metabolism.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"40 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149209859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Hydrophobic StructureAssembled Based on Zein Inhibitsthe Occurrence of Wheat Preharvest Sprouting 基于玉米蛋白组装的疏水结构抑制小麦收获前发芽的发生

IF 6.1 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-15 DOI: 10.1021/acs.jafc.6c11204

Huilan Zhang,Wenke Wang,Caiguo Tang,He Meng,Qianyi Li,Yan Duan,Lifang Wu

{"title":"A Hydrophobic Structure\u0000Assembled Based on Zein Inhibits\u0000the Occurrence of Wheat Preharvest Sprouting","authors":"Huilan Zhang,Wenke Wang,Caiguo Tang,He Meng,Qianyi Li,Yan Duan,Lifang Wu","doi":"10.1021/acs.jafc.6c11204","DOIUrl":"https://doi.org/10.1021/acs.jafc.6c11204","url":null,"abstract":"Abstract Global climate-related disasters have made preharvest sprouting (PHS), a critical constraint on improving wheat yield and quality. Current prevention strategies primarily rely on breeding new varieties, which face challenges such as prolonged breeding cycles and the difficulty of balancing high yield/quality with sprouting resistance. Meanwhile, existing chemical control agents suffer from inconsistent efficacy, instability, and risks of nonpoint source pollution. In this study, an eco-friendly silicon dioxide nanoparticle/chitosan/zein composite (SCZ) was developed using zein as the natural hydrophobic agent, chitosan (CS) as a base membrane-forming polysaccharide, and silicon dioxide nanoparticles (SiO2 NPs) as filler, each at a final concentration of 1% (w/v). Through optimized ingredient ratios and application methods, field trials demonstrated that SCZ spray achieved over 40% control efficacy against wheat PHS. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) characterization indicated that SCZ formed a compact composite structure with hydrophobic characteristics on the wheat grain surface. This structure blocked water infiltration and thereby inhibited preharvest sprouting. Physiologically, SCZ treatment reduced malondialdehyde (MDA) accumulation and suppressed peroxidase (POD) and alpha-amylase (α-amylase) activation during germination, indicating that SCZ inhibits preharvest sprouting by alleviating oxidative damage and limiting starch mobilization. This research provides theoretical insights into PHS control mechanisms and proposes a novel approach for developing green antisprouting agents, offering significant economic benefits and promising application prospects for sustainable wheat production.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"89 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlorantraniliprole Suppresses the Humoral Immunity in Spodoptera frugiperda Larvae by Downregulating Peptidoglycan Recognition Protein Gene SfPGRP-S5 氯虫腈通过下调肽聚糖识别蛋白基因SfPGRP-S5抑制夜蛾幼虫体液免疫

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-10-01 DOI: 10.1021/acs.jafc.6c08585

Qingyan Liu, Wenqi Xie, Jiaxin Liu, Shuhua Liu, Xiaoyue Deng, Qing Li, Yanli Yue, Huabao Chen, Qunfang Yang, Chunxian Jiang

{"title":"Chlorantraniliprole Suppresses the Humoral Immunity in Spodoptera frugiperda Larvae by Downregulating Peptidoglycan Recognition Protein Gene SfPGRP-S5","authors":"Qingyan Liu, Wenqi Xie, Jiaxin Liu, Shuhua Liu, Xiaoyue Deng, Qing Li, Yanli Yue, Huabao Chen, Qunfang Yang, Chunxian Jiang","doi":"10.1021/acs.jafc.6c08585","DOIUrl":"10.1021/acs.jafc.6c08585","url":null,"abstract":"Previous studies have demonstrated that chlorantraniliproleenhancescellular immunity in Spodoptera frugiperda larvae, but its effects on humoral immunity remain unclear. Thus,we investigated the role of this insecticide in modulating humoralresponses, focusing on peptidoglycan recognition proteins (PGRPs)as key mediators. PGRPs are important pattern recognition receptorsthat activate insect innate immunity against microbes. Our findingsrevealed that chlorantraniliprole inhibited humoral immunity in larvae,with the expression of SfPGRP-S5 being significantlyaffected. Functional studies revealed that SfPGRP-S5 knockdown under chlorantraniliprole exposure decreased larval survivalfollowing bacterial infection and downregulated antimicrobial peptide(AMP) genes, while recombinant SfPGRP-S5 activated AMP and prophenoloxidase(PPO) expression. Additionally, the transgenic Drosophila bioassay indicated that SfPGRP-S5 overexpressionenhanced chlorantraniliprole tolerance and reduced bacterial susceptibility.In summary, SfPGRP-S5 plays a critical role in mediatingchlorantraniliprole-induced suppression of humoral immunity in S. frugiperda larvae. This study reveals the differentialimmune regulation by insecticides and provides new insights for understandingtheir sublethal effects.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31478–31490"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the Impacts of a Biopesticide and a Synthetic Pesticide on Potato Production: A Multi-Omics Analysis of Carvacrol and Dimethomorph 生物农药与合成农药对马铃薯生产的影响比较：马铃薯地霉霉多组学分析

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-09-30 DOI: 10.1021/acs.jafc.6c09742

Weitao Wang, Wenyuan Huang, Sarah J. Knight, Karin Müller, Long Cheng, Fan Xiang, Jiahuan Long, Melanie Kah

{"title":"Comparing the Impacts of a Biopesticide and a Synthetic Pesticide on Potato Production: A Multi-Omics Analysis of Carvacrol and Dimethomorph","authors":"Weitao Wang, Wenyuan Huang, Sarah J. Knight, Karin Müller, Long Cheng, Fan Xiang, Jiahuan Long, Melanie Kah","doi":"10.1021/acs.jafc.6c09742","DOIUrl":"10.1021/acs.jafc.6c09742","url":null,"abstract":"Long-term application of synthetic pesticides for potatolate blightcontrol has raised many ecological concerns, while broader impactsof biopesticides on production systems remain unclear. Field trialscompared the effects of pesticides dimethomorph (synthetic) and carvacrol(biological) against an untreated control in a potato production system,integrating untargeted metabolomics, metabarcoding and quality traitanalyses. Compared with the control group, both pesticide treatmentsupregulated tuber lipid metabolism but downregulated leaf defense-associatedmetabolism. For rhizosphere communities, while both treatments reducedbeneficial bacterial taxa, carvacrol exerted less suppressive effectsthan dimethomorph and resulted in superior pathogen suppression. Thesechanges were associated with enhanced potato quality under carvacroltreatment, with starch, flavonoid, and vitamin C contents each morethan 10% higher than under dimethomorph. This study highlights theimportance of evaluating both productivity end points and soil ecologicalconsequences in field conditions, providing novel insights into theintegration of biopesticides in sustainable crop production.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31951–31962"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperoside Derived from Actinidia arguta Bee Pollen Alleviates Zearalenone-Induced Hepatotoxicity and Oxidative Stress in Piglets via the PI3K/AKT Signaling Pathway 猕猴桃花粉提取的金丝桃苷通过PI3K/AKT信号通路减轻玉米赤霉烯酮诱导的仔猪肝毒性和氧化应激

IF 6.7 1区农林科学

Journal of Agricultural and Food Chemistry Pub Date : 2026-10-14 Epub Date: 2026-10-02 DOI: 10.1021/acs.jafc.6c05739

Nannan Liu, Dongfei You, Yunfei Jiang, Tianyu Han, Guangliang Shi

{"title":"Hyperoside Derived from Actinidia arguta Bee Pollen Alleviates Zearalenone-Induced Hepatotoxicity and Oxidative Stress in Piglets via the PI3K/AKT Signaling Pathway","authors":"Nannan Liu, Dongfei You, Yunfei Jiang, Tianyu Han, Guangliang Shi","doi":"10.1021/acs.jafc.6c05739","DOIUrl":"10.1021/acs.jafc.6c05739","url":null,"abstract":"Zearalenone (ZEA) is a prevalent mycotoxin inducing hepatotoxiceffects. Hyperoside (HYP), a flavonoid derived from Actinidia arguta bee pollen, exhibits hepatoprotectiveproperties against ZEA; however, the molecular mechanisms underlyingthis protection remain incompletely characterized. This study integratedin vivo piglet models, in vitro porcine hepatocytes, network pharmacology,and molecular docking to characterize the molecular targets of HYP.The results demonstrated that HYP significantly attenuated ZEA-inducedhepatic lesions and oxidative stress. Computational analyses pinpointedthe PI3K/AKT signaling pathway as the core target of HYP. In vitrovalidation revealed that HYP phenocopied the AKT activator SC79 insuppressing ZEA-induced hepatocyte apoptosis, an efficacy partiallyabrogated by the PI3K inhibitor LY294002. Conclusively, HYP amelioratesZEA-induced hepatotoxicity by activating the PI3K/AKT axis to mitigateoxidative stress and apoptosis, underscoring its translational potentialas a functional detoxifying additive for food and feed applications.","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"74 40","pages":"31810–31823"},"PeriodicalIF":6.7,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149091157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0