Nano-Structures & Nano-Objects最新文献

{"title":"Microwave-assisted synthesis of copper oxide nanoparticles using an Andrographis paniculata leaf extract: Characterization and multifunctional biological activities","authors":"Mahalakshmi Devaraji,&nbsp;Punniyakoti V Thanikachalam,&nbsp;Rajalakshmi AS,&nbsp;Rohan S,&nbsp;Bhagyalakshmi J","doi":"10.1016/j.nanoso.2024.101376","DOIUrl":"10.1016/j.nanoso.2024.101376","url":null,"abstract":"<div><div>This research delves into the environmentally friendly production of copper nanoparticles (CuNPs) using <em>Andrographis paniculata</em> leaf extract (Ap-CuNPs) and their thorough assessment for possible biological purposes. CuNPs were synthesised through a microwave-assisted method using <em>Andrographis paniculata</em> leaf extract. Characterization techniques included ultraviolet spectroscopy (UV<img>Vis), FT-IR spectroscopy, SEM, EDAX, XRD, particle size analysis, and zeta potential measurement. Biological activities were assessed through antioxidant (DPPH and H₂O₂ assays), anti-inflammatory (BSA and egg albumin denaturation assays), antimicrobial, cytotoxic (brine shrimp lethality and MTT assays), and wound healing (scratch assay) tests. Characterization confirmed the formation of Ap-CuNPs with a plasmon resonance peak at 550 nm, the presence of phytochemical capping agents, and high crystallinity. The average particle size was 69.1 nm, with a zeta potential of −12.1 mV. Ap-CuNPs exhibited significant antioxidant activity, with 88.62 % inhibition in the DPPH assay, in the H₂O₂ assay, which assesses the capacity to scavenge hydrogen peroxide, the Ap-CuNPs achieved 86.3 % inhibition at the same concentration. and anti-inflammatory activity, with 80 % inhibition in the BSA assay. Antimicrobial tests revealed strong activity against gram-negative bacteria in the 22 mm inhibition zone for <em>Pseudomonas sp</em>., for <em>S. aureus</em>, the inhibition zones were 9 mm. Cytotoxicity assessments revealed minimal effects at low concentrations, with 200 μg/ml identified as the optimal dose for wound healing. In vitro wound scratch assays demonstrated enhanced fibroblast migration and wound closure at this concentration.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101376"},"PeriodicalIF":5.45,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of self-assembling properties of paclitaxel-biotin conjugates","authors":"Dmitry V. Beigulenko ,&nbsp;Anna Yu. Belyaeva ,&nbsp;Ekaterina S. Kazakova ,&nbsp;Maria M. Antonova ,&nbsp;Aleksander S. Peregudov ,&nbsp;Aleksey A. Nikitin ,&nbsp;Tatyana S. Kovshova ,&nbsp;Yulia V. Ermolenko ,&nbsp;Konstantin A. Kochetkov","doi":"10.1016/j.nanoso.2024.101375","DOIUrl":"10.1016/j.nanoso.2024.101375","url":null,"abstract":"<div><div>Among many approaches to the creation of targeted chemotherapeutic agents, one relies on the attachment of biotin to the drug molecule. The prospect of such hybrid compounds has been demonstrated by the example of biotinylated taxane derivatives, in particular paclitaxel, which is widely used in clinical practice. However, the ability of paclitaxel-biotin conjugates to form self-assembled nanocomposites stable in aqueous media has not been revealed yet. Such a promising drug formulation would avoid the use of solubilizers often applied in conventional paclitaxel dosage forms and lead to side effects. In the present study the synthesis of paclitaxel-biotin conjugates differing in spacer chain length and hydrophobicity is described. It has been established that direct biotinylation of paclitaxel allows the resulting compound to form spherical nanoparticles. At the same time, the introduction of a hydrophilic spacer into the conjugate did not favor its ability to self-organize into such structures. It was demonstrated that the direct biotin-paclitaxel conjugate assembles into narrow-dispersed nanoparticles, which also have an optimal size (120–130 nm) for such drug delivery systems. Moreover, in the presence of non-toxic polyvinyl alcohol the nanoparticles were stable during storage. Taking into account also the ease of preparation, all these results make paclitaxel-biotin conjugate nanoparticles promising dosage forms based on paclitaxel derivatives.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101375"},"PeriodicalIF":5.45,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive models for properties of hybrid blended modified sustainable concrete incorporating nano-silica, basalt fibers, and recycled aggregates: Application of advanced artificial intelligence techniques","authors":"Boskey V. Bahoria ,&nbsp;Prashant B. Pande ,&nbsp;Sagar W. Dhengare ,&nbsp;Jayant M. Raut ,&nbsp;Rajesh M. Bhagat ,&nbsp;Nilesh M. Shelke ,&nbsp;Satyajit S. Uparkar ,&nbsp;Vikrant S. Vairagade","doi":"10.1016/j.nanoso.2024.101373","DOIUrl":"10.1016/j.nanoso.2024.101373","url":null,"abstract":"<div><div>The main objective of this work is to improve the compressive strength of concrete, specially in sustainable construction is to develop more precise predictive modeling techniques. The compressive strength prediction of basalt fiber reinforced concrete filled with nano-silica and recycled aggregates can be done using a hybrid deep learning model suggesting the use of the combination of Convolutional Neural Networks and Long Short-Term Memory networks. The CNN captures microstructural features from SEM images, while the LSTM models temporal dependencies from sequential curing data samples. To enhance the prediction accuracy, PCA was performed on feature dimensionality reduction and GA optimized hyperparameters both for the model as well as the concrete mix design for improved strength with cost effectiveness. With an R² value of 0.92–0.95, the performance results of the presented model came out better than the baseline models, as well as reducing the MAE by 20 %. Besides, there existed a 5–8 % better compressive strength in GA-optimized mix designs. Robustness comes into play with the model that shows steady strength predictions, regardless of conditions of curing under multiple conditions and at different material composition levels. Furthermore, the reutilization of recycled aggregates and nano-silica gives a real environmental benefit as less waste is produced but the material performance is maximized. This kind of outcome indicates how the proposed model can be practically applied in optimizing concrete design in terms of strength and sustainability features, thus providing an accessible instrument for decision-making in the construction field. It is an effective tool to improve the performance of concrete while minimizing environmental and material wastes.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101373"},"PeriodicalIF":5.45,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized conducting polymers in photocatalysis and opportunities for artificial intelligence applications","authors":"Hisham Kazim ,&nbsp;Moin Sabri ,&nbsp;Amani Al-Othman ,&nbsp;Muhammad Tawalbeh","doi":"10.1016/j.nanoso.2024.101371","DOIUrl":"10.1016/j.nanoso.2024.101371","url":null,"abstract":"<div><div>Water systems are being polluted by emerging contaminants at a staggering rate of 500 million tons annually. Various techniques have approached the treatment of pollutants, with photocatalysis being a viable method. Current research delved into the functionalization and nanohybridization of conducting polymers through photocatalysis in the degradation of dyes, heavy metals, and other pollutants. This review investigated the recent advancements in using functionalized conducting polymers and their composites in removing contaminants and highlights their various environmental benefits. Conducting polymers integrate dopants and heterojunctions to optimize the performance, which can, in turn, reduce wastewater pollution. Conducting polymers play a role in hydrogen production and carbon dioxide (CO₂) reduction. This review presented the role of artificial intelligence models in the optimization and prediction of degradation rates in photocatalytic processes. This review concludes that amongst the models reviewed, artificial neural networks and genetic algorithms appeared to achieve the most accurate results with an R-squared and error value of 0.998 and 1.83×10⁻⁴, respectively. Despite the progress achieved in this direction, various issues pertaining to the generalization of the experimental data to a larger scale persist. This exposes the challenges in designing well-optimized photocatalytic-membrane systems.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101371"},"PeriodicalIF":5.45,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of prescribed surface temperature and heat flux with electrical conductivity via microbial chemotaxis to enhance nanoparticle","authors":"Nahid Fatima ,&nbsp;Aaqib Majeed ,&nbsp;Nouman Ijaz","doi":"10.1016/j.nanoso.2024.101374","DOIUrl":"10.1016/j.nanoso.2024.101374","url":null,"abstract":"<div><div>The purpose of the current investigations in to explore the three-dimensional magnetohydrodynamic (MHD) Oldroyd-B nanofluid flow over an exponential stretchable surface with variable thermal conductivity. Impact of thermal radiation and gyrotactic motile organism also incorporated in the present study. A fluid that has tiny particles, also referred to as nanoparticles, scattered throughout a base fluid is called a nanofluid. These nanoparticles can be formed from metals, oxides, carbon-based compounds, or other nanomaterials, and their usual sizes range from 1 to 100 nanometers. Water, oil, ethylene glycol, or other common liquids can be used as the foundation fluid. Because of their improved physical qualities, greater heat transfer, and thermal conductivity, nanofluids have many uses in a variety of sectors. Two type of boundary conditions are associated here like prescribed surface temperature (PST) and prescribed heat flux (PHF). Exploring nanoparticles influence on a fluid viscoelasticity, and vice versa, advanced understanding of three-dimensional nanofluid flow over a porous, stretchable surface. The research also probed microorganisms' and reactions' impact on heat/mass transfer. Employing MATLAB and a similarity approach converted Navier-Stokes equations into ordinary differential equations. Outcomes included velocity profile, temperature profiles, concentration profiles, and microbe behavior. Thus, this significantly contributed to modelling collectors and thermal storage. The concentration profile flattens when the Schmidt number <span><math><mrow><mo>(</mo><mi>Sc</mi><mo>)</mo></mrow></math></span> is increased, indicating that the fluid flow behavior is clearly influenced. Moreover, these findings established ways to improve energy systems' efficiency by elucidating heat transport and fluid flow parameters. This enables sustainable energy solutions to tackle global challenges. The influence of various convergence parameters is illustrated through graphically and in the form of table. Also, our results are validated with the previously published data and found tremendous agreement.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101374"},"PeriodicalIF":5.45,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical synthesis of NiO nanoparticles from Solanum trilobatum leaf extract for antibacterial and cytotoxic properties","authors":"V. Prabha ,&nbsp;T. Janisubha ,&nbsp;S.R. Gibin ,&nbsp;P. Pandi ,&nbsp;A. Mariappan ,&nbsp;M. Tamilelakkiya ,&nbsp;P. Velusamy","doi":"10.1016/j.nanoso.2024.101337","DOIUrl":"10.1016/j.nanoso.2024.101337","url":null,"abstract":"<div><div>The chemical precipitation approach was employed to synthesize Nickel oxide nanoparticles (NiONPs) using Solanum trilobatum leaf extract as the stimulant and Nickel nitrate as the precursor. The Nickel oxide is examined using a range of characterization methods including X-ray diffraction, Fourier Transform Infrared spectroscopy, High-Resolution Transmission Electron Microscopy, High-Resolution Scanning Electron Microscopy, X-ray photoelectron spectroscopy, Thermo gravimetric Analysis/Derivative Thermo gravimetric Analysis, Diffuse Reflectance Spectroscopy, cytotoxicity and antimicrobial investigations The X-ray diffraction examination determined that the average size of the crystals increases as the quantities of leaf extract in the NiO₂ composites rise. The decrease in line broadening (β) value and the increase in leaf extract concentrations may be the cause of this phenomenon. The FTIR spectrum confirms that the as-synthesized NiO-NPs are of great purity and match well with the XRD pattern. The thermal stability of the synthesized samples was determined using TGA/DTG analysis. The analysis was conducted in an air atmosphere, with the temperature increasing at a rate of 10°C per minute. The temperature range for the analysis was from room temperature to 750°C. The optical properties are determined by the use of Diffuse Reflectance Spectroscopy, which examines the coordinated movement of electrons in the conduction band when exposed to electromagnetic waves. Rat skeletal muscle cell line and SKMEL cancer cells were cultured on 96-well plates and incubated at 37°C and 5 % CO₂ for 24 hours to allow them to adapt to the culture conditions. An investigation was conducted to assess the antibacterial properties of synthesized nanocomposites against two types of bacteria: gram-positive <em>Staphylococcus aureus</em> (MTCC No: 87) and gram-negative <em>Escherichia coli</em> (MTCC No: 443), in order to explore their potential for biological applications.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101337"},"PeriodicalIF":5.45,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing the impact of group 7 transition metals (TM: Mn, Tc, Re) encapsulated Ge-doped graphitic carbon nitrides (TM_Ge@g-C3N4) nanostructure as sensors for fenitrothion; an organophosphate insecticide","authors":"Daniel G. Malu ,&nbsp;Abo I. Nta ,&nbsp;Ita I. Oyosukhu ,&nbsp;Terkumbur E. Gber ,&nbsp;Favour A. Nelson ,&nbsp;Abasifreke U. Johnson","doi":"10.1016/j.nanoso.2024.101367","DOIUrl":"10.1016/j.nanoso.2024.101367","url":null,"abstract":"<div><div>The prevalence and detrimental effect of insecticides on the environment and human health highlights the necessity for developing effective sensing and adsorbing materials. Among these, organophosphate insecticides have garnered significant attention due to their widespread use, and potential adverse effects. Herein, the electronic properties of graphitic carbon nitride (g-C3N4) were engineered by doping with Ge-atom (Ge@C3N4) which was further enhanced by encapsulating the surface with manganese (Mn), technetium (Tc), and rhenium (Re) atom using density functional theory (DFT) at the GD3BJ-B3LYP/def2svp level of theory. The obtained results unveiled that the incorporation of Mn, Tc, and Re metals into the Ge@C3N4 framework significantly altered the electronic structure of the composite materials and enhanced the adsorption of Fenitrothion (FTT). After interaction of fenitrothion unto the engineered surfaces, a decrease in the energy gap was observed following a trends; Mn_Ge@C3N4 &gt; Re_Ge@C3N4 &gt; Tc_Ge@C3N4 with their respective energy from 1.972 eV to 1.892 eV, 1.333 eV to 1.172 eV, and 1.129 eV to 1.094 eV. And, Ge@C3N4 demonstrating a slight increase in the energy gap delineating the effectiveness of the modified compounds in sensing and adsorbing FTT. Interestingly, the adsorption studies proved to be chemisorption with the observed energies following the pattern base on their sensing capabilities Ge@C3N4 &lt; Mn&lt; Tc&lt; Re corresponding to the energies as thus: −1.533 eV, −1.602 eV, −1.622 eV, −1.653 eV depicting Rhenium-encapsulated Ge@C3N4 doped surface the more favorable for the adsorption of FTT molecule followed by technetium-encapsulated Ge@C3N4. It was further observed that all the mechanistic adsorption studies and visual studies analyses presented Re_Ge@C3N4 as the most efficient surface for adsorption and detection of FTT_.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101367"},"PeriodicalIF":5.45,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure patterns of one-step synthesis of CuNi nanopowders in air environment: Experiment and atomistic simulations","authors":"Valentin Romanovski ,&nbsp;Nickolay Sdobnyakov ,&nbsp;Andrey Kolosov ,&nbsp;Kseniya Savina ,&nbsp;Nikita Nepsha ,&nbsp;Dmitry Moskovskikh ,&nbsp;Illia Dobryden ,&nbsp;Zhaowei Zhang ,&nbsp;Evgenii Beletskii ,&nbsp;Elena Romanovskaia","doi":"10.1016/j.nanoso.2024.101377","DOIUrl":"10.1016/j.nanoso.2024.101377","url":null,"abstract":"<div><div>A possibility for one-step synthesis of bimetallic CuNi nanopowders in a different ratio of Ni to Cu by solution combustion synthesis technique under normal air atmosphere without any post reduction is reported. The effect of different types of fuels like citric acid and glycine on the combustion process and characteristics of resultant solid products were investigated. XRD results showed the existing of CuNi as a main phase and small amounts of CuO and (Ni,Cu)₄N. Determined CuNi particle sizes were in the range of up to 50 nm. Computer simulation was performed using the molecular dynamics method for similar concentration compositions, but in size range of 4.5–5.5 nm, as a result of cooling the system from 1700 K to 300 K. In addition, two types of melting scenario of binary CuNi NPs were studied: 1) heterogeneous melting of monocrystalline Cu and Ni NPs; 2) melting of the crystallization products of binary NPs. Melting temperatures weakly depend on the choice of the above-mentioned melting scenario. However, the nature of subsequent crystallization can be influenced by the initial energy of the system, which is higher for case 1. The characteristic temperatures of phase transitions of melting and crystallization are determined based on the analysis of hysteresis loops of the specific potential part of the internal energy of NPs. The patterns of atomic and structural segregation in binary CuNi NPs were studied.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101377"},"PeriodicalIF":5.45,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of filler loading on the frictional, thermal and mechanical properties of ABS/boron nitride (h-BN) nanocomposites","authors":"Elssa George ,&nbsp;Jomon Joy ,&nbsp;Poornima Vijayan P ,&nbsp;Henri Vahabi ,&nbsp;Soney C. George ,&nbsp;Saithalavi Anas","doi":"10.1016/j.nanoso.2024.101372","DOIUrl":"10.1016/j.nanoso.2024.101372","url":null,"abstract":"<div><div>The effect of hexagonal boron nitride (h-BN) nanoparticles in acrylonitrile butadiene styrene (ABS) polymer matrix is investigated. ABS/h-BN nanocomposites were prepared with h-BN content ranging from 0.5 to 5 wt% and their frictional, thermal and mechanical properties were evaluated. XRD analysis showed that the 'd' spacing in h-BN stacks increased in the ABS nanocomposite due to the interpenetration of ABS polymer chains. The tensile properties and thermal stability of ABS matrix showed better improvement with 0.5 wt% addition of h-BN nanoparticles. The tensile fracture mechanism in ABS/h-BN nanocomposites was predicted using tensile fracture surface analysis. Coats-Redfern approach was applied to support the thermal stability analysis results. Significant enhancement (28 %) in frictional property of ABS was observed in the nanocomposite with h-BN. Wettability and flame retardancy of the ABS/h-BN nanocomposites were also investigated.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101372"},"PeriodicalIF":5.45,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the versatility of copper-based nanoparticles as contrast agents in various imaging modalities","authors":"Tochukwu Perpetua Okonkwo ,&nbsp;Osemudiamhen D. Amienghemhen ,&nbsp;Adachukwu N. Nkwor ,&nbsp;Ikhazuagbe Hilary Ifijen","doi":"10.1016/j.nanoso.2024.101370","DOIUrl":"10.1016/j.nanoso.2024.101370","url":null,"abstract":"<div><div>The utilization of copper-based nanoparticles (NPs) for biomedical imaging has garnered significant attention in recent years, offering promising avenues for enhanced diagnostic and therapeutic applications. This comprehensive review synthesizes insights from a plethora of studies spanning various imaging modalities, including magnetic resonance imaging (MRI), positron emission tomography (PET), ultrasound, and photoacoustic imaging. Key advancements in nanoparticle synthesis methods, contrast agent design, and multimodal imaging approaches are highlighted, showcasing the transformative potential of copper-based NPs in biomedical imaging. Several studies have focused on optimizing the synthesis of copper-based NPs to achieve precise control over size, shape, and surface properties, thereby enhancing their imaging performance and biocompatibility. Strategies such as encapsulation within polymeric nanocarriers and functionalization with biocompatible coatings have been explored to mitigate toxicity concerns and improve stability in physiological environments. Moreover, the integration of copper ions with other imaging agents, such as gadolinium in layered double hydroxide (LDH) nanoparticles, has led to synergistic effects and enhanced contrast enhancement in MRI applications. Targeted delivery strategies have emerged as a key area of research, aiming to achieve precise localization of NPs within specific tissues or biomarkers for improved diagnostic accuracy and therapeutic efficacy. Multimodal imaging agents, combining copper NPs with complementary imaging modalities, offer synergistic advantages and comprehensive diagnostic information. Furthermore, the development of theranostic nanoparticle platforms holds promise for personalized medicine approaches, enabling simultaneous imaging and therapy within a single nanoparticle system. Despite these advancements, numerous challenges persist, including concerns regarding biocompatibility, toxicity, stability, and scalability. Addressing these challenges requires interdisciplinary efforts and collaboration between academia, industry, and regulatory agencies. Moreover, navigating regulatory hurdles and conducting rigorous preclinical and clinical studies are essential steps towards clinical translation. In conclusion, the utilization of copper-based NPs in biomedical imaging represents a burgeoning field with immense potential for revolutionizing healthcare.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101370"},"PeriodicalIF":5.45,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}