Nano-Structures & Nano-Objects最新文献

{"title":"Transethosomes: A novel lipid nanocarrier for enhanced skin penetration in drug delivery systems","authors":"Vishakha Desai,&nbsp;Suma Naduvinamai,&nbsp;Sanket Gawade,&nbsp;Nagesh C","doi":"10.1016/j.nanoso.2026.101671","DOIUrl":"10.1016/j.nanoso.2026.101671","url":null,"abstract":"<div><div>The search for the best drug delivery systems has driven the development of lipid-based vesicular carriers, which are biodegradable, biocompatible, and highly adaptable in encapsulating hydrophilic and lipophilic drugs. Among these, transethosomes, a recently emerging new generation ultra-deformable lipid vesicles, represent a new vehicle in breaking the conventional delivery pathway limitation. Joining the structural characteristics of ethosomes with the flexibility characteristics of transfersomes, transethosomes have also emerged as a system of increased skin penetration and controlled drug delivery. Since its discovery in 2012, this novel nanocarrier system has been formulated with an objective of overcoming the shortfalls of traditional modes of drug delivery in order to reach maximum therapeutic effect without side effects. This work talks about how transethosomes hold the key to revolutionizing the field, providing an era of effective and efficient drug delivery systems.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101671"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green-synthesised Cu-doped cobalt ferrite nanoparticles using Azadirachta indica leaf extract for photocatalytic and antibacterial applications","authors":"Arti Rao ,&nbsp;Preeti Thakur ,&nbsp;Atul Thakur","doi":"10.1016/j.nanoso.2026.101662","DOIUrl":"10.1016/j.nanoso.2026.101662","url":null,"abstract":"<div><div>Copper-doped cobalt ferrite nanoparticles, Co_(1-x)Cu_xFe₂O₄ (x = 0.0–0.9), were successfully synthesised via a green sol-gel technique using <em>Azadirachta indica</em> leaf extract. The X-ray diffraction (XRD) analysis confirmed the formation of a single-phase cubic spinel structure, with crystallite sizes ranging from 12 to 31 nm. Structural and physicochemical properties were analysed using XRD, SEM, FTIR, Raman spectroscopy, DLS and VSM. The incorporation of copper significantly impacted the structural, magnetic, and catalytic properties. Among the various compositions, the sample with x = 0.5 exhibited enhanced photocatalytic performance with faster reaction kinetics, 97% degradation of Eosin Y (EY) under visible light irradiation. Antibacterial studies revealed enhanced activity against Escherichia coli and Staphylococcus aureus, with compositions in the range of x = 0.3–0.5 showing the highest inhibition efficiency. The improved performance is attributed to effective charge separation, increased defect density, and enhanced generation of reactive oxygen species (ROS). These findings highlight the potential of green-synthesised Cu-doped CoFe₂O₄ nanoparticles as efficient multifunctional materials for environmental remediation and antimicrobial applications.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101662"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient fluoride capture by Mg–Zr–Al trimetallic oxide nanocomposites: Synthesis, calcination effects, and performance","authors":"Supriya Mandal,&nbsp;Bholanath Panda,&nbsp;Debasish Mondal,&nbsp;Julekha Khatun,&nbsp;Satyan Karmakar,&nbsp;Debasis Dhak","doi":"10.1016/j.nanoso.2026.101692","DOIUrl":"10.1016/j.nanoso.2026.101692","url":null,"abstract":"<div><div>Trimetallic magnesium–zirconium–aluminium mixed metal oxide (MZAO) nanocomposites were synthesised via a solution combustion route and calcined at 500 °C, 600 °C, and 700 °C to elucidate the influence of thermal treatment on fluoride adsorption. The samples were abbreviated as MZAO-500, MZAO-600, and MZAO-700 respectively. Calcination temperature played a decisive role in regulating surface hydroxyl density, surface charge, and the combined interaction among Mg, Zr, and Al active sites. Lower calcination temperature (MZAO-500) preserved a higher density of surface hydroxyl groups and a more favourable positive surface charge, as evidenced by zeta potential analysis, thereby enhancing electrostatic attraction and ion-exchange interactions with fluoride ions. Consequently, MZAO-500 exhibited superior adsorption performance. As estimated from the Langmuir model the maximum fluoride uptake capacities of MZAO-500, MZAO-600, and MZAO-700 58.37, 36.27, and 24.11 mg/g respectively. Equilibrium data were better described by the Freundlich isotherm, indicating heterogeneous adsorption arising from likely distributed surface sites. Adsorption kinetics followed a pseudo-second-order model, suggesting chemisorption-dominated fluoride capture. Thermogravimetric analysis confirmed excellent thermal stability of the nanocomposites above 800 °C. Efficient fluoride removal was achieved within a pH range of 5–8, with high selectivity retained in the presence of competing anions such as chloride, sulphate, and nitrate. X-ray photoelectron spectroscopy supporting the adsorption mechanism governed by surface hydroxyl group and electrostatic effects. These findings demonstrate that calcination-driven tuning of surface chemistry is critical for maximizing the fluoride adsorption efficiency of trimetallic oxide nanocomposites.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101692"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing visible-light photoactivity of TiO₂ by bio-inspired cerium incorporation into the crystal lattice","authors":"Parmeshwar Lal Meena ,&nbsp;Ajay Kumar Surela ,&nbsp;Manisha Kumhar ,&nbsp;Reena Yadav ,&nbsp;Hari Ram Dhanetia","doi":"10.1016/j.nanoso.2026.101696","DOIUrl":"10.1016/j.nanoso.2026.101696","url":null,"abstract":"<div><div>Ce-doped TiO₂ nanophotocatalysts were successfully synthesized via a green route using <em>Leucaena leucocephala</em> leaf extract to enhance visible-light photocatalytic activity. XRD analysis confirmed the anatase phase of TiO₂, while peak shifts toward higher 2θ values and peak broadening after Ce incorporation indicated lattice distortion, microstrain, and suppressed crystallite growth. Crystallite size calculated using the Scherrer and Williamson–Hall methods showed a significant reduction for Ce-doped TiO₂, confirming dopant-induced lattice perturbation. FTIR spectra revealed characteristic Ti–O–Ti vibrations along with Ce–O-related bands, broad O–H stretching, and phytochemical-derived functional groups, demonstrating the role of the leaf extract as a natural capping and stabilizing agent. UV–Vis studies showed enhanced visible-light absorption and band-gap narrowing from 3.32 eV for pristine TiO₂ to 3.17 eV for Ce-doped TiO₂ due to Ce-induced defect states and improved charge separation. Under visible-light irradiation, Ce-doped TiO₂ exhibited superior photocatalytic performance, achieving 93.42% degradation of methylene blue within 160 min, compared to 40.82% for pure TiO₂. The pseudo-first-order rate constant increased to 0.01579 min⁻¹ . These findings demonstrate that green-synthesized Ce-doped TiO₂ possesses enhanced light-harvesting ability, efficient charge separation, and improved surface reactivity, making it a sustainable and efficient photocatalyst for visible-light-driven dye degradation.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101696"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic genomic effects of zinc oxide and copper oxide nanoparticles conjugated with nisin on Staphylococcus aureus","authors":"Parisa Hosseini,&nbsp;Simin Rashidi,&nbsp;Bahram Golestani Eimani","doi":"10.1016/j.nanoso.2026.101661","DOIUrl":"10.1016/j.nanoso.2026.101661","url":null,"abstract":"<div><div>The global escalation of antimicrobial resistance has significantly compromised the effectiveness of traditional antibiotics, creating an urgent need for innovative and reliable antimicrobial strategies. Advances in nanobiotechnology have highlighted metal oxide nanoparticles, particularly zinc oxide (ZnO) and copper oxide nanoparticles (CuO NPs), as economically viable materials with notable antibacterial activity. In this work, the antimicrobial efficacy of ZnO NPs, CuO NPs, nisin, and zinc oxide and copper oxide nanoparticles conjugated with nisin was assessed against <em>Staphylococcus aureus (S. aureus)</em>. Bacterial cultures were exposed to varying concentrations (25, 50, 100, and <span><math><mrow><mn>150</mn><mspace></mspace><mi>μ</mi><mi>g</mi></mrow></math></span>/mL) across multiple incubation periods (2, 4, 6, 8, and 24 h). Genetic responses were evaluated using RAPD–PCR analysis, and the resulting banding patterns were quantified through Dice similarity coefficients followed by UPGMA clustering using NTSYS–PC software. The results demonstrated that CuO, ZnO NPs, and nisin individually inhibited bacterial growth; however, zinc oxide nanoparticles conjugated with nisin (ZnO–nisin) and copper oxide nanoparticles conjugated with nisin (CuO–nisin) exhibited substantially enhanced antibacterial performance. Notably, ZnO–nisin and CuO–nisin induced fewer detectable genomic alterations in <em>S. aureus</em>, suggesting a lower mutagenic impact while maintaining strong antimicrobial activity. Overall, these findings indicate that nisin-functionalized metal oxide nanoparticles combine high antibacterial efficacy with improved biocompatibility, positioning them as promising candidates for next-generation antimicrobial applications aimed at combating antibiotic-resistant pathogens.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101661"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147850273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocomposite biosensors for cancer biomarker detection: From sensing mechanisms to prognostic applications","authors":"Begüm Sarac ,&nbsp;Burhan Adıgüzel ,&nbsp;Seydanur Yücer ,&nbsp;Dilara Gülsüm Ozdemir Karabag ,&nbsp;Berfin Gürbüz Sahin ,&nbsp;Fatih Ciftci","doi":"10.1016/j.nanoso.2026.101657","DOIUrl":"10.1016/j.nanoso.2026.101657","url":null,"abstract":"<div><div>Nanocomposite biosensors have emerged as promising tools in the field of cancer detection and prognosis due to their enhanced sensitivity, selectivity, and rapid response times. These biosensors integrate nanomaterials such as graphene, carbon nanotubes, and metal nanoparticles within polymer matrices, resulting in hybrid materials that exhibit superior electrical, mechanical, and chemical properties. The design and working principles of nanocomposite biosensors rely on the synergistic interactions between the nanomaterials and biological recognition elements, such as antibodies, DNA probes, or aptamers, enabling highly specific detection of cancer biomarkers at low concentrations. In cancer diagnosis and prognosis, nanocomposite biosensors have demonstrated considerable potential by facilitating early and accurate detection of tumor-associated markers, which is crucial for improving patient outcomes. These biosensors are applied in various formats including electrochemical, optical, and piezoelectric platforms, each offering distinct advantages for monitoring cancer progression and response to treatment. The incorporation of nanocomposites enhances signal transduction and stability, thereby improving the reliability and reproducibility of measurements. Recent studies have highlighted their use in detecting biomarkers such as circulating tumor DNA, proteins, and microRNAs, which are pivotal in understanding cancer aggressiveness and patient prognosis. Looking forward, the development of nanocomposite biosensors is expected to advance further through integration with microfluidic systems and wearable devices, enabling real-time, point-of-care cancer monitoring. Challenges such as large-scale production, biocompatibility, and long-term stability remain, but ongoing research aims to address these barriers. This review uniquely provides a comparative evaluation of nanocomposite biosensors based on sensing mechanisms, analytical performance, and clinical applicability, offering a new classification framework for next-generation cancer biomarker detection technologies. Overall, nanocomposite biosensors represent a transformative approach in oncology, offering precise, non-invasive, and cost-effective solutions for cancer detection and prognosis, ultimately contributing to personalized medicine and improved clinical outcomes.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101657"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147798011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bandgap engineering and defect suppression in Cd–Al co-doped ZnO thin films composed of QDs","authors":"Md. Tanweer Ashraf ,&nbsp;Sameen Ahmad Khan ,&nbsp;Azhar Mazid Siddiqui ,&nbsp;Md. Naiyar Perwez ,&nbsp;Santosh Kumar","doi":"10.1016/j.nanoso.2026.101668","DOIUrl":"10.1016/j.nanoso.2026.101668","url":null,"abstract":"<div><div>Co-doped ZnO thin films with composition Cd_xAl_6-x(ZnO)₉₄; X = 0, 2, 4, &amp; 6 were synthesized via the sol-gel dip-coating method to modulate optoelectronic properties through cationic substitutions. X-ray diffraction analysis suggested a predominant wurtzite ZnO lattice. At higher Cd concentrations, additional CdO peaks appear, which reveal limited solubility and lattice perturbation due to ionic radii mismatch. The average particle size was found to decrease from 13.5 nm to 11.05 nm with increasing Cd concentration, accompanied by a significant broadening of the diffraction peaks. This is due to strain effects within the crystal lattice, which indicates a microstructural refinement in the as-synthesized samples. Electron microscopy analysis revealed strong progress from densely packed grains to a porous interconnected quantum-dot network with increasing X-values. Energy dispersive X-ray spectroscopy confirmed the stoichiometrically controlled addition of Cd-Al within the ZnO matrix. Optical absorption analysis exhibited a systematic blue shift of the band edges along with bandgap widening from 3.365 to 3.435 eV. This effect is governed by the Burstein–Moss effect and Fermi-level upshift due to increased carrier density. The simultaneous reduction in Urbach energy validated the suppression of localized defect states and enhanced optical behavior. These results determine that Cd-Al co-doping effectively modulates the electronic band structure and defect chemistry of ZnO, placing the as-deposited thin films as promising candidates for transparent electrodes and next-generation optoelectronic devices.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101668"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147798015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A DFT study of dibenzothiophene adsorption on Fe-S-, Mo-S-, and Nb-S-doped fullerene surfaces for extractive desulfurization","authors":"Eban L. Kechi ,&nbsp;Lubem Aondoakaa ,&nbsp;Okpanachi N. Oyibo ,&nbsp;Opeyemi M. Oyebanji ,&nbsp;Ekpenyong Uduak Ime ,&nbsp;Dorcas A. Oke ,&nbsp;Abdulmuiz A. Owolabi","doi":"10.1016/j.nanoso.2026.101664","DOIUrl":"10.1016/j.nanoso.2026.101664","url":null,"abstract":"<div><div>This study investigates the extractive desulfurization potential of transition metal-sulfur-doped C₇₈ fullerenes (Fe-S@C₇₈, Mo-S@C₇₈, and Nb-S@C₇₈) toward dibenzothiophene (DBT) using density functional theory. Structural analysis confirms that DBT adsorption does not significantly distort the fullerene framework, indicating good stability of all systems. The calculated HOMO-LUMO energy gaps for the pristine adsorbents range from 1.078 to 1.245 eV, with Mo-S@C₇₈ exhibiting the lowest gap. Upon adsorption, the gaps decrease to 0.931–1.142 eV, with DBT-Fe-S@C₇₈ showing the smallest value, suggesting enhanced reactivity and charge transfer. Adsorption energies reveal strong chemisorption across all systems, with values of −1.605 eV (Fe), −1.387 eV (Mo), and −2.911 eV (Nb). Maximum stabilization energies of 973.88 kcal/mol for Fe, 233.98 kcal/mol for Mo, and 1131.42 kcal/mol for Nb are found in natural bond orbital analysis results, suggesting greater charge delocalization in the Nb system. Density of states (DOS) analysis highlights significant orbital hybridization and electron redistribution upon adsorption. Noncovalent interaction analysis reveals strong attractive interactions near the metal centers, complemented by weak dispersive forces that enhance adsorption stability. Therefore, Nb-S@C₇₈ shows the better combination of adsorption strength, electronic properties, and interaction stability, making it a promising candidate for efficient removal of refractory sulfur compounds in extractive desulfurization processes. These findings provide insights for designing advanced nanostructured adsorbents with improved selectivity and efficiency for petroleum purification applications.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101664"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147798536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, optimization, and characterization of an ivermectin-loaded nanoemulsion using a quality by design approach","authors":"Ashutosh Jamloki ,&nbsp;Monika Dua ,&nbsp;Ujashkumar Shah","doi":"10.1016/j.nanoso.2026.101690","DOIUrl":"10.1016/j.nanoso.2026.101690","url":null,"abstract":"<div><div>Ivermectin is a BCS Class II drug with aqueous solubility below 0.005 mg/mL and log P of 5.83. Its topical delivery from conventional cream-based systems remains limited due to poor dermal bioavailability. The present study was carried out to develop and optimize an ivermectin-loaded topical nanoemulsion using a Quality by Design approach. QTPP definition, FMEA-based risk assessment, and 3² full factorial design were the key steps followed. From solubility screening, oleic acid, Tween 80, and propylene glycol were found to be the most suitable excipients. Among five Smix ratios evaluated through pseudoternary phase diagrams, Smix 4:1 showed the widest nanoemulsion existence zone and was hence selected. FMEA identified oil concentration (RPN = 448) and Smix concentration (RPN = 392) as critical process parameters. These were investigated across nine factorial batches and significant linear models were confirmed for all three responses. Checkpoint validation identified F10 as the optimized formulation at oil 5.83% and Smix 53.83%. It showed droplet size of 57.18 ± 2.36 nm, PDI of 0.251, transmittance of 99.8%, viscosity of 135.4 cps, and 1.43-fold higher drug release at 1 h in comparison to plain drug solution. Thermodynamic stability testing confirmed the physical robustness of the developed nanoemulsion under all stress conditions evaluated. The systematic QbD-driven optimization successfully established a robust design space for the formulation. Collectively, these findings demonstrated the potential of the optimized nanoemulsion as a promising platform for enhancing topical dermal delivery of ivermectin.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101690"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147991675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable transport in carbyne-alkyne molecular wires: Length dependence, parity effects and resonant tunneling","authors":"Iurbson Sales Costa ,&nbsp;Sara Carvalho da Luz ,&nbsp;Antonio Maia de Jesus Chaves Neto ,&nbsp;Jonas Marinho Duarte ,&nbsp;Jordan Del Nero","doi":"10.1016/j.nanoso.2026.101712","DOIUrl":"10.1016/j.nanoso.2026.101712","url":null,"abstract":"<div><div>We investigated coherent electronic transport in all-carbon two-terminal junctions formed by semi-infinite carbyne electrodes bridged by phenyl-terminated alkyne oligomers (n = 1–10 repeat units). Using self-consistent DFT (GGA-PBE) and NEGF as implemented in SIESTA/TranSIESTA (DZP-like localized basis, real-space mesh ≈200–300 Ry and dense k-sampling along the transport axis), we computed zero-bias transmission, I–V and G–V curves, projected DOS and full T(E,V) landscapes up to 1.0. V. At low bias all devices lie in an off-resonant tunneling regime: zero-bias conductance decreases strongly with bridge length, from conductances on the order of ∼20 μS for the ^{shortest bridges to below ∼0.3 μS for the longest, corresponding to transmission at E}F ^{that falls from ∼0.26 G}0 ^{to ∼4×10−3 G}0 ^{(with G}0^{= 2e2/h). At 1.0 V the current similarly} spans microampere to sub-microampere ranges (≈22 μA → ≲0.3 μA) across the series. Superposed on this dominant exponential attenuation we find reproducible odd-even (parity) modulations of conductance (tens-of-percent scale) that reflect orbital- symmetry changes when a single repeat unit is added. Finite-bias behavior is governed by discrete resonant channels: T(E,V) maps show HOMO/LUMO-derived bands entering the bias window and producing pronounced nonlinearity and conductance peaks; resonance widths decrease and spacing narrows with increasing chain length, consistent with reduced level broadening and smaller HOMO-LUMO gaps. Taken together, these results demonstrate clear design knobs, bridge length, parity, and contact matching, that tune transport from deep tunneling to resonance-dominated regimes, suggesting applications in nanoscale interconnects, bias-triggered switches and chemically sensitive molecular sensors.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"46 ","pages":"Article 101712"},"PeriodicalIF":5.45,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}