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Phyto-mediated biosynthesis of silver nanoparticles using Aloe barbadensis Miller leaves gel with improved antibacterial, anti-fungal, antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer activities 利用米勒芦荟叶凝胶进行植物介导的银纳米粒子生物合成,提高抗菌、抗真菌、抗氧化、抗炎、抗糖尿病和抗癌活性
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-10-03 DOI: 10.1016/j.nanoso.2024.101368
Pooja V. Nagime , Dwi Marlina Syukri , Tessa Sjahriani , Dessy Hermawan , Nishat M. Shaikh , Sheeba Shafi , Vijay R. Chidrawar , Sudarshan Singh , Naheed Kausar , Aliya Elamin
{"title":"Phyto-mediated biosynthesis of silver nanoparticles using Aloe barbadensis Miller leaves gel with improved antibacterial, anti-fungal, antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer activities","authors":"Pooja V. Nagime ,&nbsp;Dwi Marlina Syukri ,&nbsp;Tessa Sjahriani ,&nbsp;Dessy Hermawan ,&nbsp;Nishat M. Shaikh ,&nbsp;Sheeba Shafi ,&nbsp;Vijay R. Chidrawar ,&nbsp;Sudarshan Singh ,&nbsp;Naheed Kausar ,&nbsp;Aliya Elamin","doi":"10.1016/j.nanoso.2024.101368","DOIUrl":"10.1016/j.nanoso.2024.101368","url":null,"abstract":"<div><div>An effective topical therapeutic agent requires a multifunctional attribute such as antibacterial, antioxidant, and anti-inflammatory efficacy. The green-synthesized metallic and metallic oxide nanoparticles have shown significant applicability in this regard. Hence a biosynthesis of silver nanoparticles (AgNPs) using <em>Aloe barbadensis</em> miller leaf gel was fabricated and evaluated for effect of imperative influences such as temperature, time, and concentration of reactant on AgNPs synthesis. Furthermore, the biomimetic qualities were assessed to ensure the safety and efficacy. The synthesis of stabilized and capped AgNPs presented a UV–vis–based plasmonic resonance at ∼ 400 nm. The reduction of silver nitrate was further confirmed by the shift in FTIR spectra for -OH around 2870 cm<sup>−1</sup>. SEM and TEM images revealed cubic shape of the AgNPs. Whereas X-ray diffraction pattern indicated crystalline structure (crystallite size of ∼ 31.14 nm) with an inter-planar spacing value of 2.77, 1.96, and 1.67 Å for (200), (220), and (311) planes, respectively. In addition, AgNPs indicated a steady dispersion, homogeneity, and strong anionic zeta potential (∼ 35.4 mV). The results of antibacterial and antifungal activity demonstrated the potential of phyto-synthesized AgNPs in mitigation of infection associated with tested bacterial strain <em>Bacillus subtilis, Bacillus megaterium, Shigella flexneri, Trichoderma viride, Aspergillus niger,</em> and <em>Penicillium crysogenum</em>. Moreover, the results of hydrogen peroxide-based scavenging, anti-inflammatory, and anti-diabetic study revealed that the biosynthesized AgNPs exhibit an improved biomimetic attribute. Additionally, the biocompatibility assay demonstrated &gt; 80 % of CaCO-2 and L-929 cells viability at 1.67 μg/mL and 3.35 μg/mL, respectively. The anticancer activity of synthesized AgNPs against epithelium-like phenotype oral squamous carcinoma cells (CLS-354/WT) displayed IC<sub>50</sub> of 11.58 μg/mL. The results indicate that biogenic produced AgNPs may find suitable use as a potential therapeutic agent due to multifunctional attribute.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101368"},"PeriodicalIF":5.45,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategic insights of imparting flame retardancy into nano-cellulosic materials: A review 在纳米纤维素材料中添加阻燃剂的战略见解:综述
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-10-03 DOI: 10.1016/j.nanoso.2024.101369
Shakshi Bhardwaj, Shiva Singh, Dakuri Ramakanth, Vinay Kumar Gupta, Pradip K. Maji
{"title":"Strategic insights of imparting flame retardancy into nano-cellulosic materials: A review","authors":"Shakshi Bhardwaj,&nbsp;Shiva Singh,&nbsp;Dakuri Ramakanth,&nbsp;Vinay Kumar Gupta,&nbsp;Pradip K. Maji","doi":"10.1016/j.nanoso.2024.101369","DOIUrl":"10.1016/j.nanoso.2024.101369","url":null,"abstract":"<div><div>Nanocellulose (NC) is a biomaterial with prospective use as a futuristic material. NC-based materials have several diverse uses, and their demand is growing every year. However, because of their highly flammable nature, the use of NC in harsh settings is greatly restricted. Hence, it is crucial to minimize the risk of fire caused by NC-based materials to maintain a superior level of performance. To diminish the inherent flammability of these substances, flame-retardant elements are often added as additives to produce flame-retardant nanocomposites. Hence, in this review, we have provided a comprehensive summary of the characteristics of NC and the principles and categorization of flame retardants. Subsequently, we have discussed the methods used for the synthesis and characterization of NC-based flame-retardant materials. It also delves into the historical progressions in these materials, intending to enhance the ability to resist flames. The article investigates the fire resistance properties of several materials based on NC, including aerogels, coatings, films, and textiles. The objective of this review is to provide a comprehensive analysis of the future directions and advancements in multi-functional flame-retardant NC materials, with a focus on their potential applications in harsh situations.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101369"},"PeriodicalIF":5.45,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mixed-ligand strategy for structural modification of MOF materials to enhance the photocatalytic degradation and adsorption of organic pollutants: A review 采用混合配体策略对 MOF 材料进行结构修饰,以增强其对有机污染物的光催化降解和吸附能力:综述
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-10-03 DOI: 10.1016/j.nanoso.2024.101366
Nuhaa Faaizatunnisa , Ratna Ediati , Enis Nadia MD Yusof , Arif Fadlan , Karelius Karelius , Ummu Kulsum , Muhammad Naufal Ariesta
{"title":"The mixed-ligand strategy for structural modification of MOF materials to enhance the photocatalytic degradation and adsorption of organic pollutants: A review","authors":"Nuhaa Faaizatunnisa ,&nbsp;Ratna Ediati ,&nbsp;Enis Nadia MD Yusof ,&nbsp;Arif Fadlan ,&nbsp;Karelius Karelius ,&nbsp;Ummu Kulsum ,&nbsp;Muhammad Naufal Ariesta","doi":"10.1016/j.nanoso.2024.101366","DOIUrl":"10.1016/j.nanoso.2024.101366","url":null,"abstract":"<div><div>Pollution of water raises many concerns for the community because these substances are considered hazardous and can be detrimental to the environment. Waste such as dyes and pesticide residues are the most significant contributors to organic pollution. These hazardous and toxic materials must be properly removed from the environment to ensure and protect human health, safety, and the environment. Adsorption and photodegradation are two effective water purification techniques with high efficiency, economy, and ease of operation, promising environmental remediation through efficient energy use. Metal-organic frameworks (MOFs) that combine metal ions with organic ligands have diverse physical and chemical properties, making them excellent materials for removing toxic pollutants. MOFs possess unique structural properties and are utilized in the latest technological advancements for removing pesticides, heavy metal ions, pharmaceutical waste, and dyes. The functionalization, modification, defects, and deformations of adsorbents can improve the adsorption and photocatalytic performance of MOFs. Several essential factors related to MOF synthesis have been studied concerning structural properties, the basis of linker functionalization, the synthetic strategy of MIX-MOF assembly, mixed ligands, and framework defects, which can improve MOF performance in certain areas. Several topics will be discussed in this review, including MOFs, the strategy of using mixed ligands in MOF synthesis, and their application for treating environmental pollution.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101366"},"PeriodicalIF":5.45,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eco-friendly approach for carboxymethyl cellulose isolation from durian peel waste and aerogel scaffold preparation 从榴莲皮废弃物中分离羧甲基纤维素并制备气凝胶支架的生态友好型方法
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-10-02 DOI: 10.1016/j.nanoso.2024.101345
Kanchan Jha , Esam Bashir Yahya , Rahul Dev Bairwan , Mustafa Sabri , H.P.S. Abdul Khalil , Mardiana Idayu Ahmad , Indra Surya
{"title":"Eco-friendly approach for carboxymethyl cellulose isolation from durian peel waste and aerogel scaffold preparation","authors":"Kanchan Jha ,&nbsp;Esam Bashir Yahya ,&nbsp;Rahul Dev Bairwan ,&nbsp;Mustafa Sabri ,&nbsp;H.P.S. Abdul Khalil ,&nbsp;Mardiana Idayu Ahmad ,&nbsp;Indra Surya","doi":"10.1016/j.nanoso.2024.101345","DOIUrl":"10.1016/j.nanoso.2024.101345","url":null,"abstract":"<div><div>This research introduces a sustainable method for extracting carboxymethyl cellulose (CMC) from durian peel waste via supercritical carbon dioxide (Sc.CO<sub>2</sub>) processing, leading to the development of advanced aerogel scaffolds. The study evaluates the influence of Sc.CO<sub>2</sub> treatment times (60, 90, and 120 min) on the properties of the produced CMC, investigating enhancements in terms of thermal stability, crystallinity, and mechanical attributes through thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), and mechanical strength assessments. It was discovered that a 90-minute treatment duration yielded CMC aerogels with notable improvements in porosity, structural robustness, and mechanical resilience. This innovative approach not only proposes a viable strategy for repurposing agricultural by-products but also significantly augments the functional qualities of CMC aerogels, rendering them highly applicable in diverse fields. The outcomes underscore the efficiency of Sc.CO<sub>2</sub> treatment in refining the mechanical and thermal characteristics of CMC derived from durian peel waste, facilitating the creation of aerogel scaffolds poised for use in various sectors including drug delivery, water purification, and eco-friendly packaging, thereby contributing to the global initiatives for sustainability and efficient waste management.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101345"},"PeriodicalIF":5.45,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Poole-Frenkel conduction in CdS single-layered and CdS/SnS2 heterojunction electrode system CdS 单层和 CdS/SnS2 异质结电极系统中的 Poole-Frenkel 传导
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-10-02 DOI: 10.1016/j.nanoso.2024.101359
Yowa Nanung , Lohnye Tangjang , Hirendra Das , P.K. Kalita
{"title":"Poole-Frenkel conduction in CdS single-layered and CdS/SnS2 heterojunction electrode system","authors":"Yowa Nanung ,&nbsp;Lohnye Tangjang ,&nbsp;Hirendra Das ,&nbsp;P.K. Kalita","doi":"10.1016/j.nanoso.2024.101359","DOIUrl":"10.1016/j.nanoso.2024.101359","url":null,"abstract":"<div><div>In this communication, the prevalence of Poole-Frenkel conduction mechanism in two distinct semiconductor systems, CdS single-layered and CdS/SnS<sub>2</sub> heterojunction electrode systems, is reported. X-ray diffraction (XRD) exhibits the formation of CdS quantum dots (QDs). A High resolution transmission electron microscopy (HRTEM) shows a discrete particle distribution of SnS<sub>2</sub>, tends to assemble into nanosheets. Poole-Frenkel conduction arises due to the trap distribution of CdS dots, modified by SnS<sub>2</sub> sheets. Furthermore, the formation of heterojunctions with SnS<sub>2</sub> shows promising enhancement in charge transport, characterized by reduced trap density and improved conductivity compared pristine CdS. The findings provide valuable insights into the fundamental charge transport processes in CdS/SnS<sub>2</sub> system and offer potential avenues for optimizing the performance of electronic devices.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101359"},"PeriodicalIF":5.45,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D carbon sponge-derived from red onion skin for solid-state supercapacitor 用于固态超级电容器的红洋葱皮三维碳海绵
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-10-01 DOI: 10.1016/j.nanoso.2024.101355
Pitchaimani Veerakumar , Arun Prakash Periasamy , Arumugam Sangili , Chih-Ching Huang , Huan-Tsung Chang
{"title":"3D carbon sponge-derived from red onion skin for solid-state supercapacitor","authors":"Pitchaimani Veerakumar ,&nbsp;Arun Prakash Periasamy ,&nbsp;Arumugam Sangili ,&nbsp;Chih-Ching Huang ,&nbsp;Huan-Tsung Chang","doi":"10.1016/j.nanoso.2024.101355","DOIUrl":"10.1016/j.nanoso.2024.101355","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Hierarchical pore development has been widely explored with various biomass precursors using one or more surface activating agents and porogens to prepare three-dimensional (3D) carbon materials such as activated carbons (ACs) with high specific surface areas (SSA) for the fabrication of electrical double layer (EDLC) supercapacitor (SC) for efficient charge storage. However, purity, quality and performance of biomass derived ACs are usually concerned as toxic gases are produced from activating agents and porogens. In further connection with an effective pore structure control in such ACs, selection of the activating agent and the carbonization conditions is highly crucial. We noted that zinc chloride (ZnCl&lt;sub&gt;2&lt;/sub&gt;) activation has not been attempted with red onion (&lt;em&gt;Allium cepa. L&lt;/em&gt;) skins for energy storage applications. This motivated us to have a detailed investigation of the ZnCl&lt;sub&gt;2&lt;/sub&gt; effect on red onion skins at different temperatures. In this study to see if we can correlate the activation process to be investigated with the pore structure management in the ACs derived, mainly to see if we can deduce some meaningful relationship with the energy storage performance of the resulting 3D carbon structures. We found that 3D carbon sponges can be derived from red onion skins at 900 °C for 3 h under inert atmosphere due to the inherent assembly of quercetin molecules and anthocyanins via hydrogen bonding and π–π stacking interactions assisted surface activation, carbonization, and aromatization processes. Surface porosity measurements using BET method revealed that the SSA (∼2398 m&lt;sup&gt;2&lt;/sup&gt; g&lt;sup&gt;−1&lt;/sup&gt;) of 3D porous carbon sponges is comparable or higher than the most other biomass derived ACs. High resolution transmission electron microscopic (HRTEM) results confirmed that around each micropore and mesopore, five to ten graphitic nanolayers were created, which further interacted to form conducting networks on the 3D sponge surface. Such conducting networks stabilized the hierarchical pores and circulated the electrolyte in and around the micro/-nano cavity via controlled diffusion process which promoted an efficient charge storage at the electrochemical interface. As a result, the 3D carbon material provided a specific capacitance (&lt;em&gt;C&lt;/em&gt;&lt;sub&gt;sp&lt;/sub&gt;) value of 265 F g&lt;sup&gt;−1&lt;/sup&gt; at a current density (CD) of 1.0 Ag&lt;sup&gt;−1&lt;/sup&gt;, with two-fold higher than that provided by commercial AC materials. The all-solid-state SC fabricated with 3D carbon sponge provided a high energy density (ED) of 19.9 Wh kg&lt;sup&gt;−1&lt;/sup&gt; at a power density (PD) of 12.5 KW kg&lt;sup&gt;−1&lt;/sup&gt; with minimum IR drop (∼0.05 V), which is comparable to the ED and PD values for biomass-derived ACs reported in the literature. This work provides new insights into the preparation of 3D nanostructured ACs with sponge-like texture from a biomass precursor with good control over 3D structure, graphitic networks, and porosity development for improved e","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101355"},"PeriodicalIF":5.45,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxide-coated Al-Cu-based nanoparticles for enhanced solar water heating 用于增强太阳能热水器的氧化物涂层铝铜纳米粒子
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-10-01 DOI: 10.1016/j.nanoso.2024.101361
Sai Teja Banala, Adithyan TR, Saisupriyalakshmi Saravanan, Shyam V.S., Sreeram K. Kalpathy, Tiju Thomas
{"title":"Oxide-coated Al-Cu-based nanoparticles for enhanced solar water heating","authors":"Sai Teja Banala,&nbsp;Adithyan TR,&nbsp;Saisupriyalakshmi Saravanan,&nbsp;Shyam V.S.,&nbsp;Sreeram K. Kalpathy,&nbsp;Tiju Thomas","doi":"10.1016/j.nanoso.2024.101361","DOIUrl":"10.1016/j.nanoso.2024.101361","url":null,"abstract":"<div><div>We report the use of oxide-coated Al-Cu nanoparticles for enhanced solar water heating purposes. Both Al and Cu are earth-abundant metals, so they are chosen in this work. Furthermore, Al- and Cu-based nanoparticles have substantial absorption cross-sections in UV, visible, and some parts of the near-infrared region (∼300–1100 nm). This makes these nanoparticles useful in solar water heating applications. An aqueous synthesis approach, which yields oxide-coated Al-Cu-based nanoparticles, is used since it is scalable and eco-friendly. The effects of particle loading between 0.025–0.1 wt% in water, for use as a nanofluid, are tested under an infrared source. The oxide-coated Al-Cu nanoparticles are mostly cubic in morphology. The particles are stable in the nanofluid with zeta potential values &gt;30 mV. On dispersing 0.075 wt% of these nanoparticles in water, a 14–16 % enhancement in the saturation temperature is obtained. This implies that the heating kinetic constants are increased by ∼15 % upon addition of these nanoparticles to water. The scattering and absorption cross-sections for the Al-Cu-oxide based nanoparticle system were determined computationally by solving the Maxwell’s equations. The peak scattering cross-section was found to occur at a wavelength of 728 nm for a particle size of 50 nm. The values obtained computationally were used as inputs to solve the energy balance equations for simulating a water heating setup. A maximum temperature of 347.5 K is predicted for a volume of 500 ml water over a 12-hour solar heating time period, with an initial ambient temperature of 305 K. These values are commensurate with the experimental data, thus validating the model’s accuracy. These results suggest that Al-Cu-based nanoparticles would be promising candidates for use in solar water heating and thermal nanofluid applications.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101361"},"PeriodicalIF":5.45,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing Mitracarpus scaber extracts for green synthesis of silver nanoparticles: Exploring physicochemical properties and potential chemopreventive activity against N-methyl-nitrosourea- induced prostate carcinoma in rats 利用糙米提取物绿色合成银纳米粒子:探索N-甲基亚硝基脲诱导的大鼠前列腺癌的理化性质和潜在化学预防活性
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-10-01 DOI: 10.1016/j.nanoso.2024.101363
Temitayo I. Adesipe , Emeka J. Iweala , Ismail O. Ishola , Omotayo A. Arotiba , Abiodun H. Adebayo
{"title":"Utilizing Mitracarpus scaber extracts for green synthesis of silver nanoparticles: Exploring physicochemical properties and potential chemopreventive activity against N-methyl-nitrosourea- induced prostate carcinoma in rats","authors":"Temitayo I. Adesipe ,&nbsp;Emeka J. Iweala ,&nbsp;Ismail O. Ishola ,&nbsp;Omotayo A. Arotiba ,&nbsp;Abiodun H. Adebayo","doi":"10.1016/j.nanoso.2024.101363","DOIUrl":"10.1016/j.nanoso.2024.101363","url":null,"abstract":"<div><div>This study evaluated the influence of silver nanoparticles (AgNPs) biosynthesized using <em>Mitracarpus scaber</em> (<em>M. scaber</em>) extracts on testosterone and n-methyl-nitrosourea (MNU)-induced prostate carcinoma in rat. AgNPs were synthesized from 0.1 M AgNO<sub>3</sub> solution using the aqueous and ethanol extracts of <em>M. scaber</em> (AMS and EMS) as reducing as well as capping agents. The AgNPs produced using AMS (ANP) and EMS (ENP) were then analyzed via various spectroscopic experiments. Later on, the biological effects of ANP and ENP were evaluated on testosterone and n-methyl-nitrosourea (MNU)-induced prostate carcinoma in rat. The study found that ANP and ENP have characteristic crystalline structures, with particle sizes ranging from ∼5–20 nm and prominent absorbance peak at 425 nm was observed for ANP while absorption peaks at 410 and 675 nm were observed for ENP indicating that ANP is isotropic in nature while ENP is anisotropic in nature. The findings regarding chemopreventive effects on prostate carcinogenesis revealed that ANP caused a significant (p &lt; 0.05) reduction in prostate weight. However, both ANP and ENP, ameliorated prostatic hypertrophy (i.e., decreased prostate enlargement and acini proliferation) in rats induced with high-grade prostatic intraepithelial neoplasia. In comparison to the PCa group as well as other groups, ENP significantly (p &lt; 0.05) decreased the mean concentrations of prostate-specific antigen (PSA), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-). Also, ENP significantly restored depleted activities levels of superoxide dismutase (SOD) and catalase caused by prostate carcinogenesis. Furthermore, ENP caused a significant (p &lt; 0.05) reduction in glutathione (GSH) levels, an upregulation of DNA methyltransferase (DNMT1 and DNMT3b) expression, and activation of caspase 7. The results of the present study showed the potential anti-inflammatory, antioxidant and anti-neoplastic effects of AgNPs of <em>M. scaber</em> ethanol extract which implies that it could be used as an adjunct in the treatment of prostate cancer.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101363"},"PeriodicalIF":5.45,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in nanoparticles-based therapies for biomedical applications 基于纳米粒子的生物医学应用疗法的进展
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-10-01 DOI: 10.1016/j.nanoso.2024.101365
VijayaDurga V. V Lekkala , Madhava C. Reddy , Vajra C. Reddy , Swarna Kumari Kanthirigala , Sriram Chitta , Kakarla Raghava Reddy , Dakshayani Lomada
{"title":"Advancements in nanoparticles-based therapies for biomedical applications","authors":"VijayaDurga V. V Lekkala ,&nbsp;Madhava C. Reddy ,&nbsp;Vajra C. Reddy ,&nbsp;Swarna Kumari Kanthirigala ,&nbsp;Sriram Chitta ,&nbsp;Kakarla Raghava Reddy ,&nbsp;Dakshayani Lomada","doi":"10.1016/j.nanoso.2024.101365","DOIUrl":"10.1016/j.nanoso.2024.101365","url":null,"abstract":"<div><div>Nanoparticles present innovative approaches to enhance the treatment of various health disorders. Within a biological setting, they can penetrate cell membranes and interact with key biological molecules like nucleic acids, proteins, and lipids. Researchers have developed both inorganic and organic nanoparticles as high-quality nanocarriers for diverse biomedical purposes, including cell imaging, drug delivery, biosensors, and therapies targeting microbial infections, cancer, inflammation, and autoimmune diseases. Specifically, nanoparticles loaded with anti-inflammatory medications have shown potential in targeting specific organs, thereby improving drug effectiveness in diseases like multiple sclerosis. The immune system, a complex network of cells, organs, and tissues, defends the body against infections and diseases. Autoimmune diseases occur when immune cells become overactive within their tissues, often influenced by breakdowns in self-tolerance mechanisms and various sex-related and environmental factors. These diseases affect roughly 10 % of the global population, predominantly women. Traditional immune therapies, such as monoclonal antibodies and tumor necrosis factor inhibitors, can inadvertently suppress healthy immune cells, leading to adverse reactions. Consequently, nanoparticle-based therapies are gaining attention for their ability to target specific immune cells and enhance treatment efficacy while minimizing toxicity to non-target cells. This review provides updates on the types of nanoparticles used for treating various autoimmune disorders, focusing on strategies to limit toxicity to healthy cells.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101365"},"PeriodicalIF":5.45,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of hybrid nanofluid flow in a porous medium over an exponentially stretching sheet under Joule heating and thermal radiation: Finite difference 焦耳加热和热辐射条件下多孔介质在指数拉伸薄片上的混合纳米流体流动研究:有限差分
IF 5.45
Nano-Structures & Nano-Objects Pub Date : 2024-09-30 DOI: 10.1016/j.nanoso.2024.101350
Salma Khalil , Tasawar Abbas , R. Nawaz
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