Nano-Structures & Nano-Objects最新文献

{"title":"The past to the current advances in the synthesis and applications of silica nanoparticles","authors":"Abdullah Al Ragib ,&nbsp;Rupesh Chakma ,&nbsp;Junzheng Wang ,&nbsp;Yousef Mohammed Alanazi ,&nbsp;Mohanad El-Harbawi ,&nbsp;Gulshan Akter Arish ,&nbsp;Tariqul Islam ,&nbsp;Md. Abu Bakar Siddique ,&nbsp;Abu Reza Md. Towfiqul Islam ,&nbsp;Tapos Kormoker","doi":"10.1016/j.nanoso.2024.101395","DOIUrl":"10.1016/j.nanoso.2024.101395","url":null,"abstract":"<div><div>To deal with different important and updated applications like biomedical, pharmaceutical, industrial, agricultural, environmental, food, cosmetics, and even water purification, the synthetic approaches of solid silica nanoparticles (SSiNPs) and its porous variant mesoporous silica nanoparticles (MSiNPs) become a matter of attention. The outstanding non-toxic nature and exceptional properties like bio-mobilizability, easy surface modifiability, stability, micro or meso pore structure, volume, and high surface area make them versatile contributors and potential candidates in human civilization. This review article comprises a brief summarization of the synthesis of SiNPs chemically as well as through a green approach along with its noteworthy characteristics in which it is clearly shown how the functional molecules change the particle size and shape for multiple purposes. This article mainly focuses greatly effective all conventional chemical and green approaches of both silica nanoparticles (SiNPs) and MSiNPs (a total of 21 synthesis techniques). Also, the newly modified methods are cited in this review paper along with challenges and prospects. One of the most important discussions regarding sustainable, reliable, and eco-friendly (green) synthesis techniques and their available sources, advantages, and principles are mentioned in this paper. Finally, several relevant recent applications by many researchers are also noted with possible research in the industrial, chemical, agricultural, and biomedical life-related sectors. This review will help the researchers to gain the necessary information in perfect order which can be applied in the near future to invent and modify new methods on a bigger scale.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101395"},"PeriodicalIF":5.45,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication and characterization of Carbon Dot-induced Fe MOF for the detection and destruction of cancer cell","authors":"Sayani Maiti ,&nbsp;Suvendu Nandi ,&nbsp;Swarup Krishna Bhattacharyya ,&nbsp;Aparajita Pal ,&nbsp;Baidyanath Roy ,&nbsp;Samit Kumar Ray ,&nbsp;Mahitosh Mandal ,&nbsp;Narayan Ch. Das ,&nbsp;Susanta Banerjee","doi":"10.1016/j.nanoso.2024.101401","DOIUrl":"10.1016/j.nanoso.2024.101401","url":null,"abstract":"<div><div>Developing an effective drug delivery system that targets cancer cells while minimizing the side effects of chemotherapy continues to be a significant challenge in the field of cancer therapy. This work introduces a bio-degradable metal organic framework (MOF) scaffold system that is enhanced with carbon dots (CDs) to facilitate the precise delivery of drugs and tracing of their pathways within cancer cells. We synthesized and reduced an iron based MOF (rMOF) to enable Fenton reactions in cancer cells. The carbon dots derived from folic acid were crosslinked with the rMOF using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide <strong>(</strong>EDC-NHS) crosslinking chemistry to provide bio-sensing capabilities and subsequent incorporation of the anticancer drug 5 fluorouracil (5 FU) into this system for targeted anticancer activity. The rMOF-CD linkage is disrupted in acidic environments because of amine group protonation, which results in disintegration of the MOF structure and release of Fe²⁺ ions. These ions are capable of destroying cancer cells by engaging in Fenton reactions with the presence of H₂O₂ in the cells. Simultaneously, the release of CDs initiates fluorescence, which has been previously suppressed by the molecular structure. 5 FU exhibits substantial anticancer activity, as evidenced by its favourable release profile under acidic conditions (60.42 %). Cellular uptake and viability assessments of HeLa (cervical cancer) and MCF-7 (breast cancer) cell lines, as well as non-cancerous L929 cells, have produced promising results, particularly for folate rich HeLa cells. This study illustrates a novel method of bio-sensing by fluorescent CDs and targeted drug delivery, which is combined with MOF mediated destruction of cancer cells and Fenton reactions.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101401"},"PeriodicalIF":5.45,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142571346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QbD decorated ellagic acid loaded polymeric nanoparticles: Factors influencing desolvation method and preliminary evaluations","authors":"Priya Patel ,&nbsp;Ashish Thanki ,&nbsp;Devesh U. Kapoor ,&nbsp;Bhupendra G. Prajapati","doi":"10.1016/j.nanoso.2024.101378","DOIUrl":"10.1016/j.nanoso.2024.101378","url":null,"abstract":"<div><div>Polymeric nanoparticles are one of the emerging drug delivery systems in the field of oncology. Ellagic acid is a polyphenolic compound with vast effects like anti-cancer, anti-viral, and anti-oxidant. The ellagic acid nanoparticles was prepared by desolvation method. Formulating ellagic acid NPs using BSA enhances the stability and solubility of ellagic acid. Quality by design (QbD) based approach was adopted to improve the final quality and effectiveness of the formulation. The Critical quality attribute (CQAs) was defined and risk assessment was performed with the help of the Ishikawa fishbone diagram. Solubility analysis was done for the drug with methanol, ethanol, water, and acetone. Preliminary studies were performed to study the effect of type of desolvating agent, the concentration of polymer the pH of the polymer solution, amount of desolvating agent on the particle size and entrapment efficiency of the nanoparticles. A greater quantity of desolvating agent results in a narrower particle size because of thorough desolvation, and the increased encapsulation efficiency is linked to reduced protein-protein interactions. Desolvation process can cause the protein to gradually change structure, form clumps, and eventually form nanoparticles, so might be its shows increase in entrapment efficiency. A desolvating agent volume of 4 ml resulted in a particle size of 1724 ± 1.27 nm. When the amount of desolvating agent was increased to 6 ml and 8 ml, the particle size decreased to 160 ± 0.66 nm and 218 ± 0.47 nm, respectively. Fourier Transform Infrared Spectroscopy (FTIR) data showed no incompatibilities were observed between drug and polymer. <em>In-vitro</em> dissolution showed the nanoparticles may follow the control release pattern over 24 hours. All the formulated batches of zeta potential were found to be in the range −30 mV to +30 mV which indicated good colloidal stability of the NPs and the PDI value ranging from 0.18 to 2.8. The higher drug encapsulation of the drug was more than 50 % which gives higher drug release at a site of action and <em>in-vitro drug</em> release of more than 80 % may improve the dosage frequency. The in vitro drug release data was also studied by various kinetic models. The in vitro drug release analysis shows sustained release of drug from nanoparticles and follow Korsmeyer-Peppas model. All these findings were in good agreement which may open a new gateway for future research in the field of oral oncology.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101378"},"PeriodicalIF":5.45,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of marine collagen on nanocosmetics: A comprehensive review","authors":"Geeta Patel,&nbsp;Heema Chokshi,&nbsp;Bhupendra Prajapati","doi":"10.1016/j.nanoso.2024.101394","DOIUrl":"10.1016/j.nanoso.2024.101394","url":null,"abstract":"<div><div>Collagen, a fundamental protein in the extracellular matrix, plays a pivotal role in maintaining skin health, elasticity, and overall appearance. In recent years, marine-derived collagen has gained significant attention due to its unique properties, sustainable sourcing, and potential applications in pharmaceuticals, drug delivery systems, food industry, biomedical and cosmetic industry. Marine collagen, derived from marine organisms, has emerged as a valuable ingredient in cosmetic formulations due to its superior biocompatibility, biodegradability, and high tensile strength. In nanocosmetics, marine collagen is often incorporated into nanoparticles to improve its delivery and efficacy. The incorporation of marine collagen in nanocosmetics not only leverages its anti-aging benefits but also enhances the stability and bioavailability of other active ingredients in the formulation. This review summarizes various properties, extraction methods, processing, purification, applications and regulatory requirements of marine collagen. Additionally, potential benefits challenges, and future directions of marine collagen nanoparticles discussed in this article would be beneficial for researchers for developing newer formulations.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101394"},"PeriodicalIF":5.45,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced photocatalytic performance of magnetically reclaimable N-doped g-C3N4/Fe3O4 nanocomposites for efficient tetracycline degradation","authors":"Paramasivam Shanmugam ,&nbsp;Mohan Gopalakrishnan ,&nbsp;Siwaporn Meejoo Smith ,&nbsp;Apanee Luengnaruemitchai ,&nbsp;Soorathep Kheawhom ,&nbsp;Supakorn Boonyuen","doi":"10.1016/j.nanoso.2024.101392","DOIUrl":"10.1016/j.nanoso.2024.101392","url":null,"abstract":"<div><div>The growing environmental challenge posed by the persistence of tetracycline (TC) antibiotics in natural waters is of increasing concern. To address this, there is an imperative need for advanced methods to mitigate TC residues. Herein, we demonstrate the preparation of nitrogen-doped graphitic carbon nitride integrated with magnetic Fe₃O₄ (N-g-CN/Fe₃O₄) composites, showcasing narrow band gaps optimized for TC degradation. These advanced materials, conceived through a thermal poly-condensation approach, utilize citric acid and melamine as precursors for nitrogen and g-CN, respectively. These composites exhibit a face-centered cubic architecture, with particle dimensions between 8 to 12 nm and encompassing both meso and microporous structure. The results of the Brunauer–Emmett–Teller analysis indicated specific surface areas of 6.73 m²/g for g-CN, 69.80 m²/g for N-g-CN, 62.55 m²/g for Fe₃O₄, and 148.32 m²/g for N-g-CN/Fe₃O₄. These values demonstrate an increase in surface area upon the incorporation of heteroatom of nitrogen and Fe₃O₄, into the g-CN matrix, thus influence the photocatalytic performance. Under solar light exposure, the synthesized photocatalysts demonstrated photocatalytic activity with a degradation efficiency of 94.16 % within 120 min. Specifically, the N-g-CN/Fe₃O₄ (22.5 %) composites exhibited remarkable photocatalytic efficiency due to the narrow band gap energy between N-g-CN and Fe₃O₄, enhanced light absorption in the visible range, and effective charge carrier separation and transportation to the pollutants. N-g-CN/Fe3O4 (22.5 %) composites demonstrated good recyclability (five cycles), magnetic sustainability, and stability for the degradation of TC and emerging pollutants from wastewater using photocatalysts. Similarly, FGCN composites exhibited good recyclability (five cycles), magnetic retrievability, and stability for degrading organic and emerging pollutants from wastewater through photocatalysis. This efficiency can be attributed to the harmonious combination of nitrogen doping, refined surface area, and the natural heterojunction between N-g-CN and Fe₃O₄.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101392"},"PeriodicalIF":5.45,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of external force on the crack propagation of aluminum nanoplate using molecular dynamics approach: Insights into the fracture mechanisms of metallic nanomaterials under external loading condition","authors":"Shaymaa Abed Hussein ,&nbsp;Rassol Hamed Rasheed ,&nbsp;Murtadha M. Al-Zahiwat ,&nbsp;Abrar A. Mohammed ,&nbsp;Soheil Salahshour ,&nbsp;Sh. Baghaei","doi":"10.1016/j.nanoso.2024.101397","DOIUrl":"10.1016/j.nanoso.2024.101397","url":null,"abstract":"<div><div>It is crucial to comprehend how external forces (EFs) affect crack propagation (CP) in aluminum (Al) nanoplates to develop and create nanomaterials with enhanced mechanical characteristics. The creation of novel materials for a variety of uses, such as the aerospace, electronics, and energy sectors, may benefit from this expertise. Additionally, insights into the fracture mechanisms of nanomaterials can aid in designing more reliable and durable structures at the nanoscale. This study utilized computer models to investigate the effect of EFs on fractures in Al nanoplates. The results suggest that an EF can significantly alter CP within nanoplates. The findings provide insights into the fracture mechanisms of metallic nanomaterials under external loading conditions. Simulation results in current research showed the physical stability of modeled Al nanoplates at T=300 K as the initial temperature. Numerically, the total energy (TE) of pristine nanoplate converged to −34762.953 eV after thermodynamic equilibrium detection inside the computational box. Furthermore, the simulation results show that EF caused the crack growth procedure intensity to increase. In the present study, the crack length value increased to 33.902 Å between our modeled samples. This result led to the conclusion that in real-world applications, it is important to consider the effect of EFs on the development of cracks within Al nanoplates.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101397"},"PeriodicalIF":5.45,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive evaluation of TiO2 nanofluid stability: Insights from pH, EC measurements, and UV-Vis spectroscopy","authors":"Chakar Khadija ,&nbsp;Asdiou Nouhaila ,&nbsp;Salhi Anas ,&nbsp;Salhi Imane ,&nbsp;El Mouden Mahmoud ,&nbsp;Hajjaji Abdelowahed ,&nbsp;Muthanna H. Al-Dahhan","doi":"10.1016/j.nanoso.2024.101387","DOIUrl":"10.1016/j.nanoso.2024.101387","url":null,"abstract":"<div><div>This study delves into assessing the stability of different nanofluids containing TiO₂ nanoparticles, employing either ethylene glycol (EG) or water as the base fluid. The results obtained will be applied to photovoltaic panels in future work, in particular to solve the cooling problems facing these systems, in order to improve their efficiency and durability. The nanoparticles, approximately 75 nm in size as determined by the Debye-Scherrer equation and X-ray diffraction (XRD), were utilized to formulate nanofluids at concentrations of 0.1 %, 0.3 %, and 0.5 % using a two-step method. To gauge the stability of these prepared nanofluids, practical investigations were conducted involving pH and electrical conductivity (EC) measurements, along with UV-Vis spectroscopy spanning the wavelength range of 200–800 nm. The findings reveal that nanofluids with 0.1 % and 0.5 % TiO₂ in water demonstrated promising stability. Moreover, the absorbance levels of nanofluids containing 0.1 %, 0.3 %, and 0.5 % TiO₂ in EG, as well as 0.3 % TiO₂ in water, decreased with increasing settling time, as observed through UV-Vis spectroscopy analysis, consistent with prior research. Additionally, the study of pH and EC stability for 0.5 % TiO₂ in water indicated satisfactory results.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101387"},"PeriodicalIF":5.45,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of silver doping on structural, optical and antifungal properties of copper oxide nanoparticles prepared using Colocasia esculenta leaf extract","authors":"P. Kiran Kumar ,&nbsp;Bharathipriya Rajasekaran ,&nbsp;Vaidyanathan Vinoth Kumar ,&nbsp;Vahulabaranan Rajagopalan ,&nbsp;P. Karthik","doi":"10.1016/j.nanoso.2024.101385","DOIUrl":"10.1016/j.nanoso.2024.101385","url":null,"abstract":"<div><div>Copper oxide (CuO) nanoparticles have attracted significant interest for their diverse applications. This study focused on the eco-friendly synthesis of undoped and silver (Ag) doped CuO nanoparticles using <em>Colocasia esculenta</em> leaf extract. XRD analysis revealed a cubic crystal structure in Ag doped nanoparticles with reduced crystallinity compared to undoped counterpart. FTIR spectra confirmed the efficient encapsulation of plant extracts and significant microstructural modification due to doping. Both undoped and Ag-doped CuO nanoparticles exhibited distinct optical property, characterized by a consistent direct band gap energy of 5.3 eV. Ag-doped CuO nanoparticles demonstrated a higher negative zeta potential (-29 mV) and smaller particle size (98.5 nm), resulting in a stable colloidal dispersion with lower polydispersity index. Morphology revealed reduced agglomeration and smaller grain size in doped CuO nanoparticles, leading to more uniform, spherical particles as confirmed by EDX, which indicated the successful inclusion of Ag ions in the CuO lattice. Furthermore, Ag doping significantly enhanced antifungal activities of CuO nanoparticles (p&lt;0.01). The increased generation of reactive oxygen species led to greater microbial cell damage and higher inhibition zones, with a maximum inhibition of 28 nm and 27 nm against <em>Botrytis cinerea</em> and <em>Phoma medicaginis</em>, respectively at a concentration of 250 µg/ml. Hence, the study highlights the potential of green synthesized CuO nanoparticles, especially Ag-doped variants, as effective antifungal agents. Their versatile properties make CuO nanoparticles as a promising candidate for a wide range of applications in biomedicine and agriculture.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101385"},"PeriodicalIF":5.45,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of corrosion resistance in steel alloys with MOF-embedded coatings","authors":"Arash Fattah-alhosseini,&nbsp;Shiva Zaheri,&nbsp;Minoo Karbasi","doi":"10.1016/j.nanoso.2024.101384","DOIUrl":"10.1016/j.nanoso.2024.101384","url":null,"abstract":"<div><div>Steel is widely used due to its strength, cost-effectiveness, availability, ease of fabrication, ductility, and design flexibility. However, corrosion is a significant challenge, especially in outdoor environments, leading to gradual degradation. Applying coatings to steel and its alloys is an effective way to protect them from corrosive media. Recently, researchers have explored using metal-organic frameworks (MOFs) in protective coatings for various metal alloys. MOFs, hybrid crystalline materials made of metal ions (or clusters) bonded to organic ligands, have gained substantial interest in both organic and inorganic chemistry. They exhibit remarkable characteristics, such as high specific surface area, tunable structure and functionality, well-organized pore arrangement, and abundant active sites, making them promising anticorrosion materials. This review paper focuses on recent research developments in MOF-based corrosion protection materials and assesses their effectiveness in preventing corrosion.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101384"},"PeriodicalIF":5.45,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale modeling-driven synthesis of Cu40Zn24Ni24Ag8Hg4 high entropy alloy with antibacterial properties","authors":"Prince Sharma ,&nbsp;Sahil Rohila ,&nbsp;Uzma Hasan ,&nbsp;P. Hari Krishna ,&nbsp;Chima Ugwuegbu ,&nbsp;Abhishek Tiwari ,&nbsp;Manish Joshi","doi":"10.1016/j.nanoso.2024.101391","DOIUrl":"10.1016/j.nanoso.2024.101391","url":null,"abstract":"<div><div>High-entropy alloys (HEAs) are promising materials across various sectors, yet their potential as antibacterial powders remain underexplored. In this study, we synthesized a novel Cu-Zn-Ni-Ag-Hg-based HEA using CALPHAD and DFT methods coupled with mechanical alloying. The HEA's antibacterial efficacy against <em>Staphylococcus aureus</em> (<em>S. aureus)</em> and <em>Escherichia coli</em> (<em>E. Coli)</em> was systematically evaluated. Computational and experimental analyses confirmed the HEA's single-phase FCC structure. Mechanical alloying for 8 h facilitated the formation of the single-phase HEA, with Ni and Cu initially dissolving into each other, followed by Zn, Ag, and Hg. Antibacterial testing demonstrated minimum inhibitory concentrations of 400 µg/mL for <em>S. aureus</em> and 600 µg/mL for <em>E. coli</em>, highlighting the broad-spectrum antibacterial properties of the synthesized HEA. These results underscore the potential of HEAs in advancing antibacterial materials for biomedical applications.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"40 ","pages":"Article 101391"},"PeriodicalIF":5.45,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}