Nano-Structures & Nano-Objects最新文献

{"title":"Enhanced electrochemical properties for better stability of supercapacitance and electronic structure characteristics of Ag-doped CeO2 nanoparticles","authors":"M. Kiran ,&nbsp;N.S. Leel ,&nbsp;P.A. Alvi ,&nbsp;B. Dalela ,&nbsp;Shalendra Kumar ,&nbsp;N. Jakhar ,&nbsp;A. Sharma ,&nbsp;S. Dalela","doi":"10.1016/j.nanoso.2024.101418","DOIUrl":"10.1016/j.nanoso.2024.101418","url":null,"abstract":"<div><div>The structure and functional properties of materials can be significantly influenced by the synthesis of nanoparticles. This manuscript presents undoped CeO₂ and Ag doped CeO₂ nanoparticles (NPs) with different concentration of Ag (x = 0.03, 0.05 and 0.07), prepared using a simple coprecipitation route of synthesis. The prepared NPs have been characterized via X-ray diffraction (XRD), UV-Vis NIR spectroscopy, photoluminescence (PL), X-ray photoelectron spectroscopy (XPS) and electrochemical analysis. The XRD measurement infers the improvement in the crystalline nature with Ag-doping and crystallite size between 13 and 9 nm. The absorption spectra reflect the red shifting of the absorption peaks along with the narrowing of band gap with rise in the Ag concentration. To ascertain the defects and excitation wavelength, PL measurement has been performed. High color rendering index (CRI) of the prepared samples showed good luminescence with white light emission. The development of oxygen vacancies (V_o) upon Ag doping is further confirmed by XPS measurement. In addition, the XPS measurements revealed the charged oxygen vacancies as well as the valence states of Ce with 3+ and 4+ , Ag with 1+ , and O with 2–. The CV test verified that in 2 M KOH electrolyte solution, the 5 % Ag-doped CeO₂ NPs had the maximum specific capacitance (C_SP) value of 363.44 F/g at scan rate of 10 mV/s the best cycle stability (retaining 93.90 % after 2100 cycles). It was discovered that the 5 % Ag-doped CeO₂ NPs had an energy density of 125.08 Wh/kg and a power density of 652.48 W/kg. An excellent super capacitive performance of Ag doping in CeO₂ could be used as a unique electrode material to develop high-efficiency and durable energy storage devices and resulted in the enrichment of electrochemical properties of these nanomaterials. Cyclic voltammetry (CV) results are consistent with electrochemical impedance spectroscopy, indicating good voltammetry and impedance spectroscopy performance of Ag-doped CeO₂ NPs. These nano-materials are also better alternatives for solid state electrolyte for fuel cells, UV blockers, photo-catalyst and many other applications.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101418"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143157562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioswitchable Polyurethane Implants: Enhancing Performance with 2D Nano Additives","authors":"Anushka Grace Binod ,&nbsp;Payal Varma ,&nbsp;Balasubramanian Kandasubramanian","doi":"10.1016/j.nanoso.2025.101454","DOIUrl":"10.1016/j.nanoso.2025.101454","url":null,"abstract":"<div><div>Implants that can modify biological signals or environmental factors are now a focal point in the realm of biomedical applications. These groundbreaking devices hold immense potential to transform medical procedures and tools. Integrating 2D nano additives such as graphene, graphene oxide, and Mxene into Polyurethane (PU), due to their bioswitchability, durability, and shape memory capabilities make it an attractive material for bioswitchable implants. Although these materials have immense potential, they still face complications regarding their compatibility with living beings, capacity to bear mechanical stress, and regulated degradation rate. This can be improved by compiling them with biocompatible materials that enhance their properties. Various processing methods are explored for integrating nano additives into PU matrices, like electrospinning, 3D printing, solvent casting and particulate leaching, thermoplastic molding, and melt blending has been encompassed in this article. This review highlights PU-based bioswitchable implants’ advancements in dentistry, bone implants, drug delivery, tissue regeneration, and cancer therapy. Integrating nanomaterials enhances the implants' physical, biological, cytotoxic, and long-term monitoring profiles. The main focus is on employing robotic touch to interact with biological systems and operate implants dynamically. This research reveals that PU-based bioswitchable implants and robotic fingertips might revolutionize regenerative medicine by increasing patient outcomes.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101454"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short and long wavelength laser pulse-dependent physicochemical properties of plasmonic metal nanocomposites: A comparative assessment","authors":"Hanan Alenzi ,&nbsp;Mahmood Alhajj ,&nbsp;S.K. Ghoshal ,&nbsp;Muhammad Safwan ,&nbsp;Hana Abdullah Alluhaybi","doi":"10.1016/j.nanoso.2025.101451","DOIUrl":"10.1016/j.nanoso.2025.101451","url":null,"abstract":"<div><div>Repeated studies revealed that various nanostructures with tailored physicochemical properties are highly desirable for biomedical and engineering applications. Hence, this study investigates the systematic synthesis and characterizations of gold/copper nanocomposites (Au-CuNCs) prepared via the pulsed laser ablation in liquid (PLAL) approach. In this process, solid Au and Cu targets were ablated in deionized water (DIW) using a nanosecond pulsed laser at two different wavelengths (1064 nm and 532 nm). The primary objective is to evaluate the impact of laser wavelength variation on the structural, optical, and morphological properties of the resulting NCs. All NCs were analysed to evaluate the effect of varying wavelengths on their fluorescence, absorbance, morphology, and structure. TEM, HRTEM, and STEM images confirmed the nucleation of Au-CuNCs with the corresponding mean diameters of 7.88 ± 3.97 and 6.39 ± 4.07 nm of 1064 and 532 nm, respectively. ATR-IR and XRD analysis affirmed the high purity and strong nanocrystallinity of all specimens, respectively. EDX maps and spectra of the obtained NCs disclosed the distributions and compositions of constituent chemical elements. The lifetime decay analyses of the NCs exhibited an appreciably low fluorescence lifetime of 2.83 µs and 2.74 µs of the donor, ascribed to radiative energy transfer and photon emission. Optical band gap energy of the NCs made at 1064 nm 532 nm corresponded to 3.90 eV and 4.03 eV. It is established that via the change of the ablating laser wavelength, the physical characteristics of these NCs can be tailored, contributing to sustainable growth with diverse applications.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101451"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydromagnetic micropolar nanofluid heat and mass transfer in a porous channel with thermophoresis, brownian motion and non-uniform heat source","authors":"E.O. Fatunmbi,&nbsp;O.L. Aako","doi":"10.1016/j.nanoso.2025.101456","DOIUrl":"10.1016/j.nanoso.2025.101456","url":null,"abstract":"<div><div>Understanding heat and mass transfer in the flow dynamics of nanofluids within a porous channel has significant applications in various engineering fields, such as groundwater remediation in environmental engineering, enhanced oil recovery in petroleum engineering, and heat exchanger design in system cooling engineering, among others. In light of these applications, the current research focuses on the hydromagnetic flow and heat transfer mechanisms of a non-Newtonian micropolar nanofluid through a porous channel. A mathematical model incorporating the influence of a magnetic field, thermal radiative flux, temperature-dependent thermal conductivity, and a non-uniform heat source is developed with engineered colloidal nanoparticles using the Buongiorno model. The model is transformed into an ordinary differential equation from the initial partial differential equations using appropriate transformations. The resulting model is solved numerically to obtain the solution for the transport phenomena. Several tables are compiled, and graphs are plotted to illustrate the influence of key parameters with real engineering relevance. The investigation revealed that the skin friction coefficient significantly decreased due to the micropolar fluid parameter, while the vortex viscosity term amplified the couple stress profile. Furthermore, the systems thermal energy increased with higher thermophoresis, Brownian motion, and Peclet numbers for heat and mass diffusion. In contrast, the hydrodynamic boundary layer thickness decreased as the strength of the porosity and magnetic field terms increased.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101456"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fixed-bed-column study on arsenic removal from water using an in situ-synthesized nanocomposite of magnetite and reduced graphene oxide","authors":"Maria R. Galstenkova ,&nbsp;Yulia R. Mukhortova ,&nbsp;Artyom S. Pryadko ,&nbsp;Vladimir V. Botvin ,&nbsp;Dmitry V. Wagner ,&nbsp;Anna A. Sharonova ,&nbsp;Maria A. Surmeneva ,&nbsp;Roman A. Surmenev","doi":"10.1016/j.nanoso.2025.101431","DOIUrl":"10.1016/j.nanoso.2025.101431","url":null,"abstract":"<div><div>This study presents <em>in situ</em> synthesis of a nanocomposite of Fe₃O₄ nanoparticles directly grown on the surface of two-dimensional (2D) reduced-graphene-oxide nanosheets. The morphology, structure, chemical and phase composition, and magnetic properties of the developed nanocomposite were investigated. The nanocomposite, when mixed with sand, effectively addressed the challenge of arsenic removal from water on a fixed-bed column with sorption capacity 8.40 and 8.96 mg/g for arsenic concentrations 0.1 and 10 mg/L, respectively. This performance is superior to that reported in the literature for alternative iron-containing arsenic sorbents. The sorption isotherms were modelled using the Thomas model and the R-square value was around 0.9, reflecting good correlation between the experimental data and isotherm model. The As³⁺ sorption process caused no significant changes in structure, phase composition, and magnetic properties of the nanocomposite, implying its good potential for reuse and its economic viability for applications related to arsenic removal from contaminated water.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101431"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer/POSS based robust and emerging flame retardant nanocomposites: A comprehensive review","authors":"Ayesha Sattar ,&nbsp;Shahzar Hafeez ,&nbsp;Mateen Hedar ,&nbsp;Muhammad Saeed ,&nbsp;Tajamal Hussain ,&nbsp;Azeem Intisar","doi":"10.1016/j.nanoso.2024.101427","DOIUrl":"10.1016/j.nanoso.2024.101427","url":null,"abstract":"<div><div>Synthetic polymers are extensively utilized in electronics, automobiles, building materials and numerous other commercial items where different types of flame retardants are employed to develop safety among these polymers. Higher safety requirements include efficient flame-retardancy, great persistence, low release of heat, smoke and toxic gases and no considerable change in the overall properties of these polymers. Polyhedral oligomeric silsesquioxane (POSS) are three dimensional architectures that can be effectively introduced in almost all existing polymers to attain desired properties. This review focuses on their thermal, mechanical and flame retardant characteristics with commonly used polymer/POSS nanocomposites using epoxy resins, cellulose, silicone rubber, polyamide, polyimide, polyurethanes, polypropylene etc. owing to their remarkable structural and functional characteristics i.e., thermal stability, low toxicity, environmental neutrality and biocompatibility. The goal of this study is to provide an overview of the most significant and state-of-the-art developments in polymer/POSS nanocomposites and their variants. Owing to their great potential towards fire retardancy and excellent physical properties, various robust materials have been mentioned and critically discussed. General properties, methods of preparation, mechanism and modes of action of polymer / POSS nanocomposites have also been presented. Furthermore, challenges and possible future prospects have also been discussed.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101427"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Larvicidal effects of biofabricated iron nanoparticles made from the aqueous extracts of Eupatorium adenophorum and Artocarpus hirsutus, with their effect on the predatory efficiency of mosquito fish","authors":"C.T. Sunila ,&nbsp;V.P. Sylas ,&nbsp;Neethu Cyril ,&nbsp;Raisa Kabeer ,&nbsp;Jerry Mechery ,&nbsp;B.N. Anila ,&nbsp;Smitha Knox","doi":"10.1016/j.nanoso.2024.101430","DOIUrl":"10.1016/j.nanoso.2024.101430","url":null,"abstract":"<div><div>The present study investigated the larvicidal effect of bio-synthesized iron nanoparticles (FeNPs) using two tropical plant species, <em>Artocarpus hirsutus</em> and <em>Eupatorium adenophorum</em> against <em>Culex quinquefasciatus</em> mosquito larvae. The synthesized nanoparticles, AH-FeNP and EA-FeNP were characterized by UV–vis spectroscopy, XRD analysis, AFM, HR-TEM, and EDX. Preliminary phytochemical studies and FTIR confirmed the presence of secondary metabolites with hydroxyl, amine, and carbonyl as reducing/ capping agents. Results of the characterization indicated that the plant-mediated Fe-NPs have the size of 29–36 nm and had high crystalline nature. As synthesized nanoparticles have shown considerable larvicidal activity against <em>C. quinquefasciatus</em> with LC₅₀ and LC₉₀ values of 3.316 mg/L and 6.558 mg/L for AH-FeNP, 3.296 mg/L and 7.529 mg/L for EA-FeNP respectively. Furthermore, the result revealed that both FeNPs have distinct concentration-dependent larval mortality. They were toxic at higher concentrations (35 mg/L) and showed 76.66 % mortality of mosquito larvae for AH-FeNP and 73 % for EA-FeNP. The in-situ experiment with both FeNPs and their effect on the mosquito fish <em>Gambusia affinis</em> have shown an improved efficiency of predation and the fishes have no ill effects after being susceptible to both FeNPs for a week. Overall, the result depicts that both AH-FeNP and EA-FeNP have mosquito larvicidal activity especially against larvae of <em>C. quinquefasciatus</em> and the in-vitro exposure study showed that they are less toxic to fishes like <em>G.affinis.</em> The present work also suggests bioaugmented iron nanoparticles can be contemplated as a futuristic, efficacious and environmentally safe pesticide.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101430"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charge-specific and hesperidin loaded mesoporous silica nanoparticles: Enhanced antimicrobial activity against pathogenic bacteria","authors":"Divya Sree H.R.,&nbsp;Satyanarayana Swamy Vyshnava,&nbsp;Muralidhara Rao Dowlathabad","doi":"10.1016/j.nanoso.2025.101441","DOIUrl":"10.1016/j.nanoso.2025.101441","url":null,"abstract":"<div><div>This study successfully synthesized and evaluated mesoporous silica nanoparticles (MSNs) for charge-based antimicrobial delivery systems. The presence and development of MSN particles were verified by UV-Visible spectroscopy, which exhibited distinct peaks that corresponded with prior research. The MSNs, which were examined using HR-TEM (high-resolution transmission electron microscopy) and FE-SEM (field emission scanning electron microscopy), had a spherical shape with an average diameter of 65.0 ± 2.0 nm. They were found to be amorphous, as confirmed by XRD (X-ray diffraction) and SAED (selected area electron diffraction) patterns. The presence of amino, carboxyl, and PEG groups on the surface was confirmed by FTIR, suggesting that the modification was successful. The modified MSNs exhibited differences in hydrodynamic size and surface charge, as evidenced by dynamic light scattering (DLS) and zeta potential tests. The most efficient loading of hesperidin (Hes) was attained when the ratio of MSN to Hes was 1:10, as determined by UV-Visible spectra. The MSN-Hesperidin with a positive charge displayed the most potent antibacterial action against E. coli and Pseudomonas aeruginosa. It showed greater effectiveness compared to MSNs with a negative charge, MSNs with no charge, and free Hesperidin. The improved antibacterial efficacy can be ascribed to the efficient interaction between positively charged MSNs and bacterial cell membranes, along with the regulated release characteristics of the MSNs.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101441"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confined selenium chains in one-dimensional mordenite nanochannels: A TEM and Raman spectroscopy study","authors":"Edgar Mosquera-Vargas ,&nbsp;Mario A. Millan-Franco ,&nbsp;Carlos Marín","doi":"10.1016/j.nanoso.2025.101448","DOIUrl":"10.1016/j.nanoso.2025.101448","url":null,"abstract":"<div><div>This study investigates the incorporation of selenium chains into the nanochannels of hydrated mordenite (MOR) using high-resolution TEM imaging, Raman spectroscopy, and computational simulations. The results reveal that selenium chains are successfully incorporated within the mordenite framework, with changes in image contrast confirming its presence. Raman spectroscopy was employed to identify the selenium species in Se-MOR, revealing characteristic vibrational modes associated with trigonal selenium structures. Raman spectrum for Se-MOR displayed peaks at 250 cm^–1, attributed to symmetric bond-stretching, and at 265 cm^–1, linked to antisymmetric bond-stretching, confirming the presence of selenium chains within the nanochannels of the mordenite structure. Crystallographic modeling and TEM analysis show that these selenium chains are integrated into specific nanochannels, influencing the Se-MOR growth directions. TEM imaging and SimulaTEM simulations at 300 and 400 keV in bright field mode show no changes in pure mordenite but reveal darker regions in Se-MOR corresponding to selenium chains. STEM_CELL simulations in dark field mode confirm increased intensity in selenium-rich regions, consistent with conventional TEM mode observation. Comparisons between simulated and experimental Raman spectrum show good agreement, suggesting that selenium chains primarily occupy small nanochannels in hydrated mordenite, while larger nanochannels in dehydrated mordenite may accommodate a range of selenium species. Additionally, the study explores the impact of water molecules on selenium incorporation, showing that only selenium chains are formed in the small channels in the presence of water.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101448"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colloidal formulations of etoposide based on self-assembling oleyl-hyaluronan-based structures: Optimization of technology and in vitro analysis","authors":"M.M. Antonova ,&nbsp;S.Sh. Karshieva ,&nbsp;A.A. Nikitin ,&nbsp;Yu.A. Malinovskaya ,&nbsp;D.V. Ermolin ,&nbsp;A.S. Novikov ,&nbsp;E.V. Skorb ,&nbsp;D.V. Beigulenko ,&nbsp;T.S. Kovshova ,&nbsp;E.A. Kalacheva ,&nbsp;A.A. Filin ,&nbsp;S.E. Gelperina ,&nbsp;Yu.V. Ermolenko","doi":"10.1016/j.nanoso.2025.101443","DOIUrl":"10.1016/j.nanoso.2025.101443","url":null,"abstract":"<div><div>The ability of the conjugate of hyaluronic acid and oleic acid (oleyl hyaluronan — HA-C18:1) to form self-assembling micellar structures was utilized to enhance the water solubility of the anticancer drug etoposide (ETP) and its prodrug, 4-O′-benzyloxycarbonyl derivative (ETP-Cbz). Using density functional theory (DFT), it was established that the ETP-Cbz associate with HA-C18:1 had greater thermodynamic stability compared to the ETP associate, which was confirmed experimentally. The micelles loaded with ETP-Cbz were smaller (268 nm compared to 407 nm), more stable (with the critical micelle concentration (CMC) decreasing from 0.07 to 0.025 mg/mL), and had the higher drug loading efficiency (82 %) as compared to HA-C18:1/ETP micelles. In vitro experiments showed that both micellar formulations exhibited low hemolytic activity and delayed drug release profiles during the first hours. In vitro cytotoxicity against MCF-7 and MDA-MB-231 cell lines showed the dose-dependent decrease in cell viability whereas the toxic effect against normal human dermal fibroblasts (NHDF) was significantly lower and exceeded the concentration of HA-C18:1 in the micellar formulations. Confocal microscopy was used to confirm the active uptake of micellar formulations by MDA-MB-231 cells. These findings, therefore, suggest that HA-C18:1 may be a promising solubilizing agent for etoposide and its prodrug.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":"41 ","pages":"Article 101443"},"PeriodicalIF":5.45,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143100515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}