Advances in Neurodevelopmental Disorders最新文献_第4页

Macro- and Microstates of Resting-State EEG in Children with Low-Functioning Autism 低功能自闭症儿童静息脑电图的宏观和微观状态

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-11-21 DOI: 10.1007/s41252-023-00374-x

Galina Portnova, Olga Martynova

{"title":"Macro- and Microstates of Resting-State EEG in Children with Low-Functioning Autism","authors":"Galina Portnova, Olga Martynova","doi":"10.1007/s41252-023-00374-x","DOIUrl":"10.1007/s41252-023-00374-x","url":null,"abstract":"<div><h3>Objectives</h3><p>Resting-state EEG (rsEEG) offers unique advantages for examining brain activity in children with autism spectrum disorder (ASD) due to their challenges in following instructions and heightened sensory hypersensitivity. To investigate functional brain states, it is essential to focus on the temporal dynamics of rsEEG.</p><h3>Methods</h3><p>We applied two methods with different time resolutions (macrostate or <i>k</i>-means clustering of the continuous rsEEG segment and microstate analysis of shorter temporal EEG epochs) to study the transient states of brain electrical activity in several age groups of children. A total of 158 children with low-functioning ASD and 177 typically developing (TD) children aged 2 to 14 years participated in the study. The groups were matched for age, gender, and IQ.</p><h3>Results</h3><p>The results indicated that in the control group, micro- and macrostates exhibited increased age-related dynamics during maturation. We identified micro- and macrostates with similar topographies related to salience, sensory processing, and the default mode network (DMN). The coverage of macro- and microstates associated with sensory processing and DMN was significantly higher in children with ASD. Children with ASD displayed a shorter coverage of macro- and microstates with interhemispheric asymmetry compared to the TD group.</p><h3>Conclusions</h3><p>The obtained results support previous findings regarding atypical resting-state EEG microstate patterns in ASD when compared to TD children. Additionally, EEG microstates and macrostates exhibit age-related changes that differ between ASD and TD individuals. The findings related to EEG micro- and macrostates have promising implications for the diagnosis and rehabilitation of children with low-functioning autism.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 4","pages":"559 - 573"},"PeriodicalIF":1.3,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139253464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accessing Community Settings by Creating Safe Practice Contexts: An Ecologically Valid Applied Behavior Analytic Understanding 通过创造安全的实践环境进入社区环境：生态学上有效的应用行为分析理解

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-11-16 DOI: 10.1007/s41252-023-00369-8

Jennifer Quigley, Art Dowdy, Lauren Palmieri Haneman

{"title":"Accessing Community Settings by Creating Safe Practice Contexts: An Ecologically Valid Applied Behavior Analytic Understanding","authors":"Jennifer Quigley, Art Dowdy, Lauren Palmieri Haneman","doi":"10.1007/s41252-023-00369-8","DOIUrl":"10.1007/s41252-023-00369-8","url":null,"abstract":"<div><h3>Objectives</h3><p>Individuals diagnosed with intellectual and/or developmental disabilities (IDDs) are often excluded from community-based activities. One common reason for exclusion is the occurrence of severe challenging behavior in the community. The objective of this study was to support this population’s inclusion in community-based activities.</p><h3>Methods</h3><p>We evaluated the effectiveness and ecological validity of two multicomponent behavior interventions aimed to reduce challenging behavior in community-based contexts using a single-case experimental design for two participants. Prior to intervention, both youths with IDD were restricted from community outings due to challenging behavior in those settings and challenging behavior previously resulted in police intervention.</p><h3>Results</h3><p>For both individuals and based upon visual analysis, multicomponent behavior intervention resulted in successful community outings when progressing from a practice context to a community-based context. Furthermore, multicomponent intervention gains were identified across a variety of local community stores when parents implemented intervention.</p><h3>Conclusions</h3><p>These findings (a) highlight the importance of ecologically valid research in behavior analysis and (b) support the use of multicomponent behavior intervention implemented by parents in community-based contexts.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 4","pages":"524 - 535"},"PeriodicalIF":1.3,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139267534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances and Challenges in the Assessment of Executive Functions in Under 36 Months: a Scoping Review 36 个月以下儿童执行功能评估的进展与挑战：范围界定综述

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-11-13 DOI: 10.1007/s41252-023-00366-x

Valeria Escobar-Ruiz, Pedro I. Arias-Vázquez, Carlos A. Tovilla-Zárate, Eduardo Doval, Maria C. Jané-Ballabriga

{"title":"Advances and Challenges in the Assessment of Executive Functions in Under 36 Months: a Scoping Review","authors":"Valeria Escobar-Ruiz, Pedro I. Arias-Vázquez, Carlos A. Tovilla-Zárate, Eduardo Doval, Maria C. Jané-Ballabriga","doi":"10.1007/s41252-023-00366-x","DOIUrl":"10.1007/s41252-023-00366-x","url":null,"abstract":"<div><h3>Objectives</h3><p>Neurodevelopmental disorders present deficits in executive functions (EFs). Before 36 months old, EFs act as basic abilities that allow adequate executive functioning at later ages. Three basic EFs are assessable before the child reaches 36 months old: working memory, inhibition, and cognitive flexibility. This review aims to provide an overview of the progress and difficulties in assessing these three basic executive functions before children reach 36 months old.</p><h3>Methods</h3><p>Four databases were systematically searched without time or language limitations. The selection process was done using a PRISMA flowchart for scoping reviews. Sixteen studies were included, all in English and published between 2004 and 2021.</p><h3>Results</h3><p>Out of 277 studies, 16 met the inclusion criteria. The general data of the studies were summarized, such as sample age, type of study, measurement features, types of EFs assessed, task names, internal structure, reliability, and main contributions. The findings on available tasks and scales, factor structure, biological and environmental factors, and the variables influencing EFs before 36 months old are described.</p><h3>Conclusions</h3><p>Multiple factors influenced the evolution of EFs. The unidimensional model seems to better explain EFs before 36 months old. Expanding psychometric research with large samples and studying samples of children with symptoms at risk for neurodevelopmental disorders may help to improve the measurement of EFs before 36 months old.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 3","pages":"365 - 383"},"PeriodicalIF":1.3,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41252-023-00366-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136346524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self- and Informant Report in a First-Time Diagnosis of Autism Spectrum Disorder in Adulthood: the Role of Females 成年期自闭症谱系障碍首次诊断中的自我报告和线人报告：女性的作用

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-11-10 DOI: 10.1007/s41252-023-00371-0

Antonio F. Pagán, Amy K. Izuno-Garcia, Killian R. Hughes, Katherine S. Chapman, Katherine A. Loveland

{"title":"Self- and Informant Report in a First-Time Diagnosis of Autism Spectrum Disorder in Adulthood: the Role of Females","authors":"Antonio F. Pagán, Amy K. Izuno-Garcia, Killian R. Hughes, Katherine S. Chapman, Katherine A. Loveland","doi":"10.1007/s41252-023-00371-0","DOIUrl":"10.1007/s41252-023-00371-0","url":null,"abstract":"<div><h3>Objectives</h3><p>The diagnosis of autism spectrum disorder (ASD) in adulthood is a growing area of research and practice as the number of adults seeking a first-time diagnosis has increased. Informants are often utilized to aid in the evaluation of ASD in childhood. Little is known regarding the convergence of self- and informant-report measures of ASD in adults and whether gender differences exist. We explored the convergence of self-report and informant ratings on two commonly used rating scales and a clinician observation measure for the diagnosis of ASD.</p><h3>Methods</h3><p>The present study explored the convergence of two commonly used measures (SRS-2 & AQ) and a clinician observation measure for the diagnosis of ASD in adulthood 155 pairs of adults (41.3% female; mean age = 33.19, <i>SD</i> = 11.46) and their informants (total sample, <i>n</i> = 310).</p><h3>Results</h3><p>Overall, self-report AQ and SRS-2 scores were significantly higher than informants. Gender was the most important predictor of poor convergence on AQ and SRS-2, with informants of females reporting significantly fewer ASD symptoms compared to males with a first-time diagnosis of ASD in adulthood. Informant report also did not significantly predict key functional outcomes (i.e., employment, living situation) over and above self-report alone. The present study also found no significant differences in measures regardless of the informant utilized (e.g., parents, spouses).</p><h3>Conclusions</h3><p>Gender is an important factor in the assessment of ASD in adulthood. Thus, practitioners assessing female adults ought to interpret discrepant informant-report results with caution. Researchers ought to continue to examine how ASD measures perform for females and ensure they are normed appropriately with females and males. A wider variety of informants such as a sibling or a friend may be appropriate if a parent or spouse is unavailable.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 4","pages":"536 - 546"},"PeriodicalIF":1.3,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135137227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social Impairment in the Autistic Spectrum: Real-Life Versus Online Perceived Social Skills 自闭症谱系中的社交障碍：现实生活中与网络上的社交技能对比

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-11-02 DOI: 10.1007/s41252-023-00368-9

Rachel Poulain, Céline Cappe, Magali Batty

{"title":"Social Impairment in the Autistic Spectrum: Real-Life Versus Online Perceived Social Skills","authors":"Rachel Poulain, Céline Cappe, Magali Batty","doi":"10.1007/s41252-023-00368-9","DOIUrl":"10.1007/s41252-023-00368-9","url":null,"abstract":"<div><h3>Objectives</h3><p>While socio-communicative difficulties are identified as a core diagnostic criterion for autism spectrum disorder (ASD), there is growing evidence that social difficulties could be context-dependent and could be overcome by the use of online communication. Beyond the spectrum, the symptoms of ASD can be met in the general population at a milder scale, leading researchers to extend their work to subjects with high autistic traits, also called the broader autism phenotype. The present study explored online versus real life social skills in the general population according to the level of autistic traits.</p><h3>Method</h3><p>Seventy-one adults without ASD (from 18 to 55 years old) reporting using social networks completed a questionnaire assessing their real-life and online social skills. Their autistic traits were assessed using the autistic quotient (AQ).</p><h3>Results</h3><p>Results showed a direct influence of the level of autistic traits on real-life and online social skills: Participants having high autistic traits demonstrated a lower level of real-life social skills <i>(r = − 0.26, p < 0.05</i>) and conversely higher online social skills <i>(r = 0.28, p < 0.05</i>), suggesting that social difficulties might be context-dependent.</p><h3>Conclusions</h3><p>While further studies are needed in a population with ASD, our results report preliminary evidence of the potential benefit of online social interactions within the autistic spectrum. Further studies in ASD could consider the potential for using an electronic mediator within social remediations.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 3","pages":"499 - 508"},"PeriodicalIF":1.3,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135934538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Restrictive Practice Use in People with Neurodevelopmental Disorders: A Systematic Review 神经发育障碍患者限制性练习的使用：系统回顾

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-10-19 DOI: 10.1007/s41252-023-00367-w

Ben Younan, Mikaela Jorgensen, Jeffrey Chan, Teresa Winata, Donna Gillies

{"title":"Restrictive Practice Use in People with Neurodevelopmental Disorders: A Systematic Review","authors":"Ben Younan, Mikaela Jorgensen, Jeffrey Chan, Teresa Winata, Donna Gillies","doi":"10.1007/s41252-023-00367-w","DOIUrl":"10.1007/s41252-023-00367-w","url":null,"abstract":"<div><h3>Objectives</h3><p>Restrictive practices (RP) include any practice or intervention that infringes on the rights and freedom of movement of people with disability, including those with neurodevelopmental disorders (NDD). The use of RP is inconsistent with the United Nations Convention on the Rights of Persons with Disabilities (CRPD). The objective of this systematic review was to estimate the use of RP internationally and identify factors associated with RP use.</p><h3>Methods</h3><p>Six electronic databases alongside a comprehensive online search were conducted for literature up to 12th December 2022. This systematic review included any publication published within the past 18 years that reported the rate of RP in at least 250 people in residential, community, and hospital settings who had a NDD.</p><h3>Results</h3><p>Twenty publications reporting thirty datasets were included in this review. Sample sizes ranged from 268 to 107,392. Overall rates of RP ranged from 6% to 78% across different timeframes and populations. Chemical restraint was the most commonly reported RP, with 12 of 20 publications (60%) reporting rates across one or more timeframes. Higher prevalence of RP were found in populations with higher reported mental illness and behaviors of concern.</p><h3>Conclusion</h3><p>The very considerable differences between publications and limited data means that the rates of RP are variable. The high variability appears to be attributable to methodological differences. Requiring the reporting of RP through legislation is one mechanism that can support better monitoring of RP and ultimately ensure progress is being made towards CRPD obligations to uphold human rights.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 1","pages":"122 - 140"},"PeriodicalIF":1.3,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135778405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical Prescribing of Psychotropic Medications for People with Neurodevelopmental Disorders 为神经发育障碍患者开具精神药物处方的伦理问题

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-10-12 DOI: 10.1007/s41252-023-00365-y

Shoumitro Deb, Bharati Limbu, Annamaria Bianco, Marco Bertelli

{"title":"Ethical Prescribing of Psychotropic Medications for People with Neurodevelopmental Disorders","authors":"Shoumitro Deb, Bharati Limbu, Annamaria Bianco, Marco Bertelli","doi":"10.1007/s41252-023-00365-y","DOIUrl":"10.1007/s41252-023-00365-y","url":null,"abstract":"<div><h3>Objectives</h3><p>People with neurodevelopmental disorders (NDDs) such as intellectual and developmental disabilities (IDD) and autism are subjected to restrictive practices like physical restraint and the overuse of psychotropic medications for challenging behaviour in the absence of a psychiatric disorder. This practice may lead to human rights violations. Rational and evidence-based shared decision-making for person-centred planning will help reduce this practice.</p><h3>Methods</h3><p>We have discussed in this paper the issue of the overmedication of people with NDD, explaining how this practice may violate the United Nations (UN) Convention on the Rights of Persons with Disabilities (CRPD).</p><h3>Results</h3><p>We have discussed how the following UN CRPD Articles may be affected by overmedication, including Article 15 (degrading treatment or punishment), 16 (abuse), 17 (the integrity of the person), and 25 (health). The other Articles that may be indirectly affected by this practice are 5 (equality and non-discrimination), 9 (accessibility), 19 (independent living and community inclusion), 21 (access to information), 24 (education), 26 (rehabilitation), 27 (work and employment), 28 (adequate living standard), and 30 (participation in recreation and leisure).</p><h3>Conclusions</h3><p>Overmedication of people with NDD, particularly the off-licence use of psychotropics for challenging behaviour, the side effects of these medications impacting the person’s quality of life are likely to violet several UN Articles on Rights of Persons with Disabilities. Following the right guidelines may help reduce these human rights violations.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 1","pages":"198 - 207"},"PeriodicalIF":1.3,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41252-023-00365-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135969323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evaluation of a Family-Based Judo Program for Youth with Autism Spectrum Disorder 自闭症谱系障碍青少年家庭柔道项目评估

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-10-10 DOI: 10.1007/s41252-023-00363-0

Jeanette M. Garcia, Caitlyn Perry, Michelle Murray, Riley Shurack, Keith Brazendale, David H. Fukuda

{"title":"The Evaluation of a Family-Based Judo Program for Youth with Autism Spectrum Disorder","authors":"Jeanette M. Garcia, Caitlyn Perry, Michelle Murray, Riley Shurack, Keith Brazendale, David H. Fukuda","doi":"10.1007/s41252-023-00363-0","DOIUrl":"10.1007/s41252-023-00363-0","url":null,"abstract":"<div><h3>Objectives</h3><p>Martial arts, such as judo, may improve health outcomes in youth with autism spectrum disorder (ASD); however, the inclusion of parents in this activity may offer additional benefits. The purpose of this study was to examine the feasibility and acceptability of a 15-week family judo program for autistic youth.</p><h3>Methods</h3><p>Nine children and their parents participated in the family class, and eight children participated in a child-only class as a comparison group. Judo sessions were held weekly for 45 min. Seven areas of feasibility (acceptability, demand, implementation, practicality, adaptation, expansion, preliminary efficacy) were assessed using attendance records, retention and recruitment rates, observation notes, and parent/instructor open-ended surveys. The Autism Behavior Inventory Short-Form (ABI-SF) was administered at baseline and post-judo to assess changes in ASD-related behaviors.</p><h3>Results</h3><p>The family class had a significantly higher attendance rate (13.22 ± .44 classes) compared to the child-only class (9.9 ± 2.5 classes, <i>p</i> = 0.007), with 100% of the family class attending at least 80% of the sessions, compared to 38% of the child-only class (<i>p</i> = 0.005). There was a significant improvement in social communication and self-regulation subscales from the ABI-SF post-judo in the family class, but no changes were observed in the child-only class. Parent open-ended survey responses indicated an observed increase in child physical activity and self-confidence post program in the family class.</p><h3>Conclusions</h3><p>The family judo class appeared both feasible and acceptable to participating families. Future studies should examine the physical and psychosocial benefits of a family program using larger samples.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 3","pages":"488 - 498"},"PeriodicalIF":1.3,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136294049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Ethical, Legal, and Social Implications of Genomics and Disability: Findings from a Scoping Review and Their Human Rights Implications 基因组学与残疾的伦理、法律和社会影响：范围界定审查结果及其对人权的影响

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-09-28 DOI: 10.1007/s41252-023-00362-1

Maria Vassos, Rhonda Faragher, Karen Nankervis, Radostina Breedt, Fran Boyle, Simon Smith, Jo Kelly

{"title":"The Ethical, Legal, and Social Implications of Genomics and Disability: Findings from a Scoping Review and Their Human Rights Implications","authors":"Maria Vassos, Rhonda Faragher, Karen Nankervis, Radostina Breedt, Fran Boyle, Simon Smith, Jo Kelly","doi":"10.1007/s41252-023-00362-1","DOIUrl":"10.1007/s41252-023-00362-1","url":null,"abstract":"<div><h3>Objectives</h3><p>Genomic advancements affect people with disabilities. This paper presents the findings of a scoping literature review on the ethical, legal, and social implications (ELSI) of genomic technologies for people with disability. The human rights implications of the ELSI findings are then discussed briefly with reference to the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD).</p><h3>Methods</h3><p>A systematic search of the ELSI literature was conducted. Via a process of abstract screening and full-text review, 288 sources of evidence were included in the review. Data extraction involved identifying the ELSI discussed in each source, which were thematically analysed to generate ELSI themes and to identify relevant linkages to the UNCRPD.</p><h3>Results</h3><p>Ten ELSI themes were identified as having relevant UNCRPD linkages including reproductive autonomy, issues related to cost and access, the downside of knowing about one’s genetic makeup, lagging legislation in light of the rapid advancement of genomic technologies, genetic discrimination, the stigmatisation and devaluation of people with disabilities, the potential resurgence of eugenics and the medical model of disability, and the involvement of people with disabilities in conversations about genomic technologies. These themes have relevant and direct linkages to several UNCRPD rights including equality, non-discrimination, diversity, accessibility, full participation, identity, and freedom of expression.</p><h3>Conclusions</h3><p>The review findings highlight that there is scope for the development of a charter on human rights specific to genomic technologies in the context of disability, which could guide ethical and socially appropriate developments in the field of genomic technologies in future.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 1","pages":"151 - 166"},"PeriodicalIF":1.3,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41252-023-00362-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135385204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Status of Psychopharmacological, Neuromodulation, and Oxytocin Treatments for Autism: Implications for Clinical Practice 自闭症的精神药物、神经调节和催产素治疗现状：对临床实践的启示

IF 1.3

Advances in Neurodevelopmental Disorders Pub Date : 2023-09-26 DOI: 10.1007/s41252-023-00364-z

Vicki Bitsika, Christopher F. Sharpley

{"title":"Current Status of Psychopharmacological, Neuromodulation, and Oxytocin Treatments for Autism: Implications for Clinical Practice","authors":"Vicki Bitsika, Christopher F. Sharpley","doi":"10.1007/s41252-023-00364-z","DOIUrl":"10.1007/s41252-023-00364-z","url":null,"abstract":"<div><h3>Objectives</h3><p>To provide an overview of the current literature regarding the neurobiological treatments of psychopharmacology, neuromodulation, oxytocin therapy, and psychological resilience, as treatments for autism-related difficulties, and to distil the research findings from those treatments for everyday clinical application.</p><h3>Methods</h3><p>Instead of producing another specific systematic summary of the efficacy of these treatments, this review took an overview of each field of research, identified its key research findings, and evaluated the treatment-ready status of each of them in terms of their evidence base. From this information, a set of recommendations were derived for their clinical applications, so as to inform practice in the field.</p><h3>Results</h3><p>These treatments represent relatively recent and neurobiologically based approaches to the challenges of autism, and are in the development stage. Each treatment is promising, and has some evidential basis for its success, but all need further research to establish their evidence-based validity for everyday clinical usage.</p><h3>Conclusions</h3><p>While most of these treatments can be applied with caution, clinicians should acknowledge their restrictive benefits and costs, that are described herein. Within those caveats, each of these treatments should be considered as an emerging therapy that clinicians should consider utilising in appropriate settings and with specific cases.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 3","pages":"355 - 364"},"PeriodicalIF":1.3,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s41252-023-00364-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134885032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0