{"title":"低功能自闭症儿童静息脑电图的宏观和微观状态","authors":"Galina Portnova, Olga Martynova","doi":"10.1007/s41252-023-00374-x","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>Resting-state EEG (rsEEG) offers unique advantages for examining brain activity in children with autism spectrum disorder (ASD) due to their challenges in following instructions and heightened sensory hypersensitivity. To investigate functional brain states, it is essential to focus on the temporal dynamics of rsEEG.</p><h3>Methods</h3><p>We applied two methods with different time resolutions (macrostate or <i>k</i>-means clustering of the continuous rsEEG segment and microstate analysis of shorter temporal EEG epochs) to study the transient states of brain electrical activity in several age groups of children. A total of 158 children with low-functioning ASD and 177 typically developing (TD) children aged 2 to 14 years participated in the study. The groups were matched for age, gender, and IQ.</p><h3>Results</h3><p>The results indicated that in the control group, micro- and macrostates exhibited increased age-related dynamics during maturation. We identified micro- and macrostates with similar topographies related to salience, sensory processing, and the default mode network (DMN). The coverage of macro- and microstates associated with sensory processing and DMN was significantly higher in children with ASD. Children with ASD displayed a shorter coverage of macro- and microstates with interhemispheric asymmetry compared to the TD group.</p><h3>Conclusions</h3><p>The obtained results support previous findings regarding atypical resting-state EEG microstate patterns in ASD when compared to TD children. Additionally, EEG microstates and macrostates exhibit age-related changes that differ between ASD and TD individuals. The findings related to EEG micro- and macrostates have promising implications for the diagnosis and rehabilitation of children with low-functioning autism.</p></div>","PeriodicalId":36163,"journal":{"name":"Advances in Neurodevelopmental Disorders","volume":"8 4","pages":"559 - 573"},"PeriodicalIF":1.3000,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Macro- and Microstates of Resting-State EEG in Children with Low-Functioning Autism\",\"authors\":\"Galina Portnova, Olga Martynova\",\"doi\":\"10.1007/s41252-023-00374-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>Resting-state EEG (rsEEG) offers unique advantages for examining brain activity in children with autism spectrum disorder (ASD) due to their challenges in following instructions and heightened sensory hypersensitivity. To investigate functional brain states, it is essential to focus on the temporal dynamics of rsEEG.</p><h3>Methods</h3><p>We applied two methods with different time resolutions (macrostate or <i>k</i>-means clustering of the continuous rsEEG segment and microstate analysis of shorter temporal EEG epochs) to study the transient states of brain electrical activity in several age groups of children. A total of 158 children with low-functioning ASD and 177 typically developing (TD) children aged 2 to 14 years participated in the study. The groups were matched for age, gender, and IQ.</p><h3>Results</h3><p>The results indicated that in the control group, micro- and macrostates exhibited increased age-related dynamics during maturation. We identified micro- and macrostates with similar topographies related to salience, sensory processing, and the default mode network (DMN). The coverage of macro- and microstates associated with sensory processing and DMN was significantly higher in children with ASD. Children with ASD displayed a shorter coverage of macro- and microstates with interhemispheric asymmetry compared to the TD group.</p><h3>Conclusions</h3><p>The obtained results support previous findings regarding atypical resting-state EEG microstate patterns in ASD when compared to TD children. Additionally, EEG microstates and macrostates exhibit age-related changes that differ between ASD and TD individuals. The findings related to EEG micro- and macrostates have promising implications for the diagnosis and rehabilitation of children with low-functioning autism.</p></div>\",\"PeriodicalId\":36163,\"journal\":{\"name\":\"Advances in Neurodevelopmental Disorders\",\"volume\":\"8 4\",\"pages\":\"559 - 573\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Neurodevelopmental Disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s41252-023-00374-x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"EDUCATION, SPECIAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Neurodevelopmental Disorders","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1007/s41252-023-00374-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"EDUCATION, SPECIAL","Score":null,"Total":0}
Macro- and Microstates of Resting-State EEG in Children with Low-Functioning Autism
Objectives
Resting-state EEG (rsEEG) offers unique advantages for examining brain activity in children with autism spectrum disorder (ASD) due to their challenges in following instructions and heightened sensory hypersensitivity. To investigate functional brain states, it is essential to focus on the temporal dynamics of rsEEG.
Methods
We applied two methods with different time resolutions (macrostate or k-means clustering of the continuous rsEEG segment and microstate analysis of shorter temporal EEG epochs) to study the transient states of brain electrical activity in several age groups of children. A total of 158 children with low-functioning ASD and 177 typically developing (TD) children aged 2 to 14 years participated in the study. The groups were matched for age, gender, and IQ.
Results
The results indicated that in the control group, micro- and macrostates exhibited increased age-related dynamics during maturation. We identified micro- and macrostates with similar topographies related to salience, sensory processing, and the default mode network (DMN). The coverage of macro- and microstates associated with sensory processing and DMN was significantly higher in children with ASD. Children with ASD displayed a shorter coverage of macro- and microstates with interhemispheric asymmetry compared to the TD group.
Conclusions
The obtained results support previous findings regarding atypical resting-state EEG microstate patterns in ASD when compared to TD children. Additionally, EEG microstates and macrostates exhibit age-related changes that differ between ASD and TD individuals. The findings related to EEG micro- and macrostates have promising implications for the diagnosis and rehabilitation of children with low-functioning autism.
期刊介绍：
Advances in Neurodevelopmental Disorders publishes high-quality research in the broad area of neurodevelopmental disorders across the lifespan. Study participants may include individuals with:Intellectual and developmental disabilitiesGlobal developmental delayCommunication disordersLanguage disordersSpeech sound disordersChildhood-onset fluency disorders (e.g., stuttering)Social (e.g., pragmatic) communication disordersUnspecified communication disordersAutism spectrum disorder (ASD)Attention-deficit/hyperactivity disorder (ADHD), specified and unspecifiedSpecific learning disordersMotor disordersDevelopmental coordination disordersStereotypic movement disorderTic disorders, specified and unspecifiedOther neurodevelopmental disorders, specified and unspecifiedPapers may also include studies of participants with neurodegenerative disorders that lead to a decline in intellectual functioning, including Alzheimer’s disease, amyotrophic lateral sclerosis, Creutzfeldt-Jakob disease, vascular dementia, Lewy body dementia, frontotemporal dementia, corticobasal degeneration, Huntington’s disease, and progressive supranuclear palsy. The journal includes empirical, theoretical and review papers on a large variety of issues, populations, and domains, including but not limited to: diagnosis; incidence and prevalence; and educational, pharmacological, behavioral and cognitive behavioral, mindfulness, and psychosocial interventions across the life span. Animal models of basic research that inform the understanding and treatment of neurodevelopmental disorders are also welcomed. The journal is multidisciplinary and multi-theoretical, and encourages research from multiple specialties in the social sciences using quantitative and mixed-method research methodologies.
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