Clinical Nutrition Open Science最新文献

{"title":"Effectiveness of interventions to improve breastfeeding outcomes among women from vulnerable ethnic groups: Protocol for a systematic review and meta-analysis","authors":"Paula Eugenia Barral ,&nbsp;Ana Veronica Scotta ,&nbsp;María Gema Cid Expósito ,&nbsp;Agustín Ramiro Miranda","doi":"10.1016/j.nutos.2025.03.002","DOIUrl":"10.1016/j.nutos.2025.03.002","url":null,"abstract":"<div><div>Despite the known benefits of breastfeeding (BF) on maternal and child health and environmental and economic levels, global BF rates are lower than recommended, especially in vulnerable ethnic groups. This review protocol is designed to analyze the interventions to promote BF in women from vulnerable ethnic groups considering the initiation, duration, and exclusivity of the practice.</div><div>The systematic review will adhere to the PRISMA guidelines. Searches will be conducted in March 2025 across eleven databases. Randomized controlled trials will be included, without language or year restrictions. The quality of the included studies will be assessed using the JBI Critical Appraisal Tool. Data will be extracted and synthesized systematically, considering a Social-Ecological Model and the Breastfeeding Gear Model. The meta-analysis will be carried out according to the Cochrane handbook for systematic reviews of interventions.</div><div>A multilevel perspective is essential for effectively implementing evidence-based BF support, particularly when considering vulnerable ethnic groups. This work will summarize the interventions to overcome barriers in the promotion of BF. Therefore, the findings of this review will integrate models in line with the Social Determinants of Health and the sustainable development goals.</div><div>PROSPERO: CRD42024529223.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 54-61"},"PeriodicalIF":0.0,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overweight and obesity combined with low physical function and non-communicable diseases among older adults in nursing homes represent a group with nutritional risk, malnutrition, and sarcopenia – A cross-sectional pilot study","authors":"Tenna Christoffersen ,&nbsp;Inge Tetens ,&nbsp;Anja Weirsøe Dynesen ,&nbsp;Margit Dall Aaslyng ,&nbsp;Janne Kunchel Lorenzen ,&nbsp;Anne Marie Beck","doi":"10.1016/j.nutos.2025.03.001","DOIUrl":"10.1016/j.nutos.2025.03.001","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Older adults with overweight and obesity (overnutrition) may be overlooked in terms of nutritional risk. The aim of the present study was to characterise older adults in community care with overnutrition according to a proposed screening model and to compare this group with older adults with normal weight in terms of nutritional risk, malnutrition, sarcopenia, or a combination of both.</div></div><div><h3>Methods</h3><div>This cross-sectional pilot study included residents from six nursing homes in a rural Danish municipality. From April to July 2022, we collected data on age, sex, body composition, chronic diseases, muscle strength, nutritional risk and dietary intake from medical records. Nutritional risk, malnutrition and sarcopenia assessments were based on the criteria set in the Eating Validation Scheme, the Global Leadership Initiative on Malnutrition and the European Working Group on Sarcopenia in Older People. A covariate analysis and a Fisher's exact test were used to evaluate differences in the variables and in nutritional risk, malnutrition and sarcopenia between the groups.</div></div><div><h3>Results</h3><div>A total of 116 residents were included in the study. We found that 52% had overnutrition and that 89% of these older adults experienced both low physical function and non-communicable diseases. Compared with older adults with normal weight, the group with overnutrition had a lower calf circumference adjusted for body mass index (<em>P</em>=0.008), a lower 30 second Chair Stand Test score (<em>P</em>=0.03), a higher prevalence of sarcopenia (<em>P</em>=0.02) and a statistically non-significant higher prevalence of malnutrition and sarcopenia combined (<em>P</em>=0.0002).</div></div><div><h3>Conclusion</h3><div>More than half of the older nursing home residents in this study had overnutrition, with almost 90% experiencing both NCDs and low physical function. When comparing the group with overnutrition with older adults with normal weight, the study showed that they had a similar prevalence of nutritional risk and malnutrition and that the prevalence of sarcopenia was higher in those with overnutrition.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 14-25"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal of a tool for screening the risk of cachexia in cancer patients","authors":"Thais Manfrinato Miola ,&nbsp;Liane Brescovici Nunes de Matos ,&nbsp;Susana da Rocha Dias","doi":"10.1016/j.nutos.2025.02.012","DOIUrl":"10.1016/j.nutos.2025.02.012","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Cancer cachexia is a multifaceted syndrome comprised of fatigue; progressive loss of functional capacity; increased risks of chemotherapeutic drug toxicity, postoperative complications, and hospitalization; decreased quality of life; and reduced survival. The objective of this study was to develop a screening tool to identify the risk of cachexia in outpatients with cancer.</div></div><div><h3>Methods</h3><div>The tool was developed to detect the risk of cachexia in outpatients treated at an oncology center. The proposed screening tool was based on diagnostic criteria for cachexia; functionality; and symptoms that may reduce alimentation. The self-administered tool was also posted on the hospital website to enable access by health professionals from other hospitals and clinics, as well as by patients.</div></div><div><h3>Results</h3><div>Data were collected from 275 patients receiving outpatient care. The most prevalent diagnosis was breast cancer (26.2%). The prevalence of metastatic cancer in the total sample was 25.1%. Risk of cachexia was identified in 37.8% of patients. Death within 30 days occurred in 47.1% (41 of 87) patients treated in the emergency room and was significantly associated with the risk of cachexia (n=39; 57.4%) (<em>P</em>&lt;0.001). Age, female sex, and metastatic disease were associated with the risk of cachexia (<em>P</em>&lt;0.001, <em>P</em>=0.014, <em>P</em>&lt;0.001, respectively).</div></div><div><h3>Conclusion</h3><div>Cachexia is a prevalent and underdiagnosed condition among cancer patients. The development of screening tools is extremely important to facilitate the early detection of patients at risk, with the aim of initiating proactive interventions.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 286-293"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional care for adult burn survivors during the rehabilitation phase","authors":"Alyaa M. Zagzoog","doi":"10.1016/j.nutos.2025.02.011","DOIUrl":"10.1016/j.nutos.2025.02.011","url":null,"abstract":"<div><h3>Background</h3><div>Innovations in medicine have increased the survival rate of patients with burn injuries. Adult burn survivors, however, need comprehensive care, which could promote their wellness after a burn injury. Proper nutritional care, inducing nutritional education provided by Registered Dietitians (RDs) plays a crucial role in improving the wellness of adult burn survivors in the acute and rehabilitation recovery phases. The nature of research in nutritional care during the rehabilitation phase, however, needs to be mapped to promote evidence-based practice. This review identified and mapped the nature of research in nutritional care for adult burn survivors during the rehabilitation phase.</div></div><div><h3>Methods</h3><div>A complete systematic search was conducted by one reviewer in conjunction with a medical librarian using the PubMed database. This review included all types of peer-reviewed publications, and the published dates and geographic locations were unlimited. Only articles involving adults with at least 20% of TBSA burn were included.</div></div><div><h3>Results</h3><div>Among 26 articles meeting the inclusion criteria, the identification and mapping of the included articles led to four key findings: the continuum of nutritional assessment and education, the effectiveness of specific nutrients on burn outcomes, the necessity of monitoring vitamin D levels, and the need of RDs as a member in a burn care team.</div></div><div><h3>Conclusions</h3><div>This review includes different study designs with broad published dates, locations, and sample size, and provides the needed identification and mapping of literature. Using more than one database and including more than one reviewer would increase the rigours of the methodology, therefore, the findings.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 294-310"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143577709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of flaxseed supplementation on metabolic syndrome risk factors; A comprehensive review","authors":"Elyas Nattagh-Eshtivani ,&nbsp;Hanieh Barghchi ,&nbsp;Alireza Hatami ,&nbsp;Mehdi Barati ,&nbsp;Ali Heydari ,&nbsp;Zohreh Abdi Moghaddam ,&nbsp;Mohammad Vahedi Fard ,&nbsp;Kimia Mohammadhasani ,&nbsp;Hamidreza Miri ,&nbsp;Saeedeh Talebi ,&nbsp;Naseh Pahlavani","doi":"10.1016/j.nutos.2025.02.010","DOIUrl":"10.1016/j.nutos.2025.02.010","url":null,"abstract":"<div><h3>Background</h3><div>Flax (also called Linum Usitatissimum) is a flowering plant with tiny seeds that are rich in fiber, omega-3 fatty acids, phenolic acids, and phytoestrogens. Recent studies have investigated the health benefits of flaxseed supplementation because of its components and antioxidant capacity. Metabolic syndrome (MetS) is a multi-factorial disorder associated with a wide range of chronic diseases. The present comprehensive review aims to summarize the effect of flaxseed supplementation on MetS.</div></div><div><h3>Results</h3><div>Flaxseed supplementation has positive effects on different health markers associated with MetS. It was associated with lower body mass index (BMI), visceral fat, and total body fat. Additionally, flaxseed supplementation reduces blood pressure (BP) by improving vasodilation. In terms of lipid profile, it attenuates low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG). Flaxseed supplementation can also improve glycemic indices, such as fasting blood sugar (FBS), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), and Quantitative Insulin Sensitivity Check Index (QUICKI). Furthermore, the antioxidant properties of flaxseeds improve oxidative stress and inflammatory markers, while increasing anti-inflammatory markers.</div></div><div><h3>Conclusion</h3><div>Flaxseed supplementation may improve MetS by affecting anthropometric indices, BP, lipid profile, glycemic indices, oxidative stress, and inflammatory markers.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 262-285"},"PeriodicalIF":0.0,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginger's nutritional implication on gastrointestinal health","authors":"Lemlem Gebremariam Aregawi ,&nbsp;Csiki Zoltan","doi":"10.1016/j.nutos.2025.02.008","DOIUrl":"10.1016/j.nutos.2025.02.008","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Ginger is a root that is high in nutritional and bioactive compounds that offer significant health benefits. Ginger has been used for centuries in traditional and alternative medicine to aid digestion, reduce nausea and provide other gastro-protective benefits. This review aims to summarize ginger's nutritional implications on gastrointestinal health and to update the current developments.</div></div><div><h3>Methods</h3><div>Clinical trials published in English were searched in PubMed, Scopus, EMBASE and Cochrane Central Register of Controlled Trial databases with keywords from inception to December 2023. The search protocol was performed under the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA,2009) guidelines. Due to the small sample size and the heterogeneity of studies, a narrative synthesis without meta-analysis is reported.</div></div><div><h3>Results</h3><div>In the current review, evidence of ginger's nutritional implications on gastrointestinal health is reported. A daily dose of 2000 mg of ginger is beneficial for reducing dyspepsia, colorectal cancer, bowel disorders and gastric ulceration in the digestive tract of patients with gastrointestinal disorders. Because of the heterogeneity and limited number of studies, the results may not be as powerful as finding significant results.</div></div><div><h3>Conclusions</h3><div>Despite the small number of studies and the large heterogeneity, the majority of the studies have shown ginger's nutritional implications on gastrointestinal health.</div></div><div><h3>PROSPERO registration number</h3><div>CRD42022378544.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of ultra-processed foods on obesity risk: A comprehensive bibliometric analysis","authors":"Richard Osei Agjei ,&nbsp;Oluwafemi Samson Balogun ,&nbsp;Sunday Adewale Olaleye ,&nbsp;Prince Owusu Adoma ,&nbsp;Michael Afari-Baidoo ,&nbsp;Frank Adusei-Mensah","doi":"10.1016/j.nutos.2025.02.009","DOIUrl":"10.1016/j.nutos.2025.02.009","url":null,"abstract":"<div><div>This study aims to analyze the research landscape pertaining to the impact of ultra-processed foods and their potential association with the risk of obesity. To achieve this objective, a comprehensive bibliometric analysis of the relevant literature published between 2013 and 2022 was conducted. The study primarily examined the prevailing research patterns, scholarly output, and thematic emphasis within scientific literature pertaining to processed foods and its association with the risk of obesity. A bibliometric methodology was utilized to conduct a comprehensive analysis of the data to obtain a thorough understanding of the patterns, thematic emphasis, and scholarly output pertaining to ultra-processed foods (UPFs) and its association with the risk of obesity. The findings derived from this bibliometric research demonstrate a dual contribution to the existing corpus of knowledge. This analysis encompasses several aspects such as current areas of focus, trends in vaccine development, and prospective avenues for future research. The research on ultra-processed foods (UPFs) and its association with obesity has been widely acknowledged and extensively explored, considering the findings reported in this study. The results of this study present potential avenues for further investigation in the realm of research collaboration among governmental/non-governmental organizations and scholars. Additionally, there is a need to broaden the scope of inquiry to explore the connections between ultra-processed foods (UPFs) and additional health-related consequences, such as diabetes and malnutrition.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 26-43"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategic approaches for managing heartburn symptoms in patients with superficial gastritis via a comprehensive dietary approach inspired by baby food","authors":"Dan Li ,&nbsp;Wei Wei ,&nbsp;Dandan Zheng","doi":"10.1016/j.nutos.2025.02.005","DOIUrl":"10.1016/j.nutos.2025.02.005","url":null,"abstract":"<div><div>Gastritis presents a multifaceted clinical conundrum, frequently exacerbated by adverse reactions associated with established therapeutic regimes. In an innovative leap, this research proposes a dietary regimen inspired by baby nutrition principles—emphasizing digestibility, balanced nutrient intake, and minimal food additives through predominantly steamed or boiled culinary methods. This regimen aims not just to alleviate gastric distress but also to potentially foster mucosal healing. Over the course of a one-month observational study, 24 subjects diagnosed with superficial gastritis were transitioned to this specialized diet. The program offers bespoke nutritional advice, which includes judicious food selection, regulation of meal sizes, and the adoption of cooking practices designed to mitigate acid reflux. Preliminary evidence, as suggested by salivary pH metrics, points towards a decrease in gastroesophageal acid exposure. Concurrently, patient's glycemic and lipid profiles exhibited stability throughout the intervention period. Remarkably, participants also reported a significant decline in depressive symptomatology, highlighting the far-reaching advantages of this avant-garde nutritional approach. This confluence of gastrointestinal and psychological benefits underscores the holistic potential of the dietary strategy in managing gastritis.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 163-180"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical experience with enteral tube nutrition and Nutrison® range of enteral tubes in patients with specific enteral feeding requirements in Spain: The NUTRECONSONDA study","authors":"M.D. Ballesteros-Pomar ,&nbsp;J.J. Alfaro-Martínez ,&nbsp;J.M. Guardia-Baena ,&nbsp;M. Riestra Fernández ,&nbsp;B. Vega-Piñero","doi":"10.1016/j.nutos.2025.02.007","DOIUrl":"10.1016/j.nutos.2025.02.007","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Enteral nutrition (EN) is a critical medical nutritional treatment designed to meet the specific micro- and macronutrient requirements of patients unable to achieve adequate nutrition through oral intake. The aim of this study is to review the use of EN by tube in routine clinical practice, focusing on its management in patients with specific nutritional requirements, and to evaluate the effectiveness, tolerability, and quality of life improvements associated with the Nutrison® range of enteral tube enteral formulas.</div></div><div><h3>Methods</h3><div>NUTRECONSONDA was a nationwide, multicentre, cross-sectional ecological study. Aggregated data were collected from the experience and knowledge of 142 physicians with experience treating patients with EN through an online survey.</div></div><div><h3>Results</h3><div>According to the physicians, the main indications to EN were neoplasms (43.3 %) and neuromotor disorders (36.4 %), the most common administration techniques were percutaneous endoscopic gastrostomy tube (35.6 %) and nasogastric tube (29.2 %), the most common type of feeding was bolus feeding (52.1 %), and most frequent symptoms were diarrhoea (29.2 %), nausea (21.7 %), regurgitation (21.4 %) and abdominal distension (21.1 %). Moreover, 82.8 % of patients reported good tolerance to enteral formulas and these were effective in 91.4 % of patients in terms of nutritional requirements. The most important criteria considered for the selection of an enteral formula of the Nutrison® range in patients with specific EN requirements were patient's energy and nutritional needs (score: 8.8), nutritional formula composition (score: 8.5) and tolerability of the formula (score: 8.3). Nutrison® enteral formulas were effective in terms of nutritional requirements in 92.5 % of patients, had good tolerability in 86.9 %, improved quality of life in 67.1 % and improved general health status in 75.1 %. Most patients were also satisfied with Nutrison® enteral formulas (87.2 %) and their delivery system (87.5 %). Furthermore, the most representative lipid profile benefits in patients treated with Nutrison® enteral formulas were a higher EPA and DHA intake (54.9 %) and a higher combination of medium chain triglycerides (45.5 %).</div></div><div><h3>Conclusion</h3><div>The key factors influencing formula selection were patient energy requirements, formula composition, and tolerance. Enteral formulas of the Nutrison® range were effective, safe and improved quality of life and lipid profile in most of the patients with specific nutritional requirements.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 200-217"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated factors of hyperuricemia in patients with CKD stages 3–5 and its relation with hemoglobin: A cross-sectional study from Syria","authors":"Mohammad Alsultan ,&nbsp;Jia Batha ,&nbsp;Mohamed Taher Anan ,&nbsp;Marwa Kliea ,&nbsp;Baraa Abdulkader ,&nbsp;Reem Kazkaz ,&nbsp;Nour Kasem ,&nbsp;Jood Barram ,&nbsp;Razan Khalaf ,&nbsp;Sally almattny ,&nbsp;Mohamad Al Masri ,&nbsp;Kassem Basha ,&nbsp;Qussai Hassan","doi":"10.1016/j.nutos.2025.02.006","DOIUrl":"10.1016/j.nutos.2025.02.006","url":null,"abstract":"<div><h3>Background</h3><div>Hyperuricemia and anemia are associated with several comorbidities in Chronic-Kidney-Disease (CKD) patients. This study aims to determine the factors related to uric acid (UA) and the relationship between UA and hemoglobin (Hb) in a sample of CKD stages 3–5.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 198 patients. Hyperuricemia was defined as a UA level of &gt;7 mgdL in males and &gt;6 mg/dL in females, while was anemia defined as Hb&lt; 11.5 g/dL. Data were compared between two UA groups [the normal UA group (UA1) and the hyperuricemic group (UA2)]. We used linear regression to determine the relationship between UA and variables.</div></div><div><h3>Results</h3><div>Hyperuricemia was reported in 55.5% of patients, where males and older patients demonstrated higher UA levels. UA2 group demonstrated higher levels of WBCs, Neutrophils percentage (NP), and phosphorus (phos) (<em>P</em> = 0.005, 0.03, and 0.002; respectively), while lymphocytes percentage (LP) showed a lower level (<em>P</em> = 0.04). Also, urea (Ur), creatinine (Cr), and lipid profiles showed non-significant higher levels in UA2 group. In regression analysis, UA showed positive relations with WBCs (<em>P</em> = 0.003), NP (<em>P</em> = 0.002), Ur (<em>P</em> = 0.01), Phos (<em>P</em> &lt;0.0001), TG (<em>P</em> = 0.01), and Chol (<em>P</em> = 0.02). UA showed negative relations with HDL (<em>P</em>= 0.002), and LP (<em>P</em> = 0.002). There was no correlation between UA and Hb even after subgroup analysis based on GFR and cut-off values of UA.</div></div><div><h3>Conclusion</h3><div>This study supported the inflammatory background associated with hyperuricemia. UA correlated with lipids profile in CKD-patients stages 3–5. There was no relation between UA and Hb in CKD patients in addition to previous conflicting data, future studies were required to establish this relationship.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 236-249"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}