Associated factors of hyperuricemia in patients with CKD stages 3–5 and its relation with hemoglobin: A cross-sectional study from Syria

Q3 Nursing

Clinical Nutrition Open Science Pub Date : 2025-02-12 DOI:10.1016/j.nutos.2025.02.006

Mohammad Alsultan , Jia Batha , Mohamed Taher Anan , Marwa Kliea , Baraa Abdulkader , Reem Kazkaz , Nour Kasem , Jood Barram , Razan Khalaf , Sally almattny , Mohamad Al Masri , Kassem Basha , Qussai Hassan

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Abstract

Background

Hyperuricemia and anemia are associated with several comorbidities in Chronic-Kidney-Disease (CKD) patients. This study aims to determine the factors related to uric acid (UA) and the relationship between UA and hemoglobin (Hb) in a sample of CKD stages 3–5.

Methods

This cross-sectional study included 198 patients. Hyperuricemia was defined as a UA level of >7 mg\dL in males and >6 mg/dL in females, while was anemia defined as Hb< 11.5 g/dL. Data were compared between two UA groups [the normal UA group (UA1) and the hyperuricemic group (UA2)]. We used linear regression to determine the relationship between UA and variables.

Results

Hyperuricemia was reported in 55.5% of patients, where males and older patients demonstrated higher UA levels. UA2 group demonstrated higher levels of WBCs, Neutrophils percentage (NP), and phosphorus (phos) (P = 0.005, 0.03, and 0.002; respectively), while lymphocytes percentage (LP) showed a lower level (P = 0.04). Also, urea (Ur), creatinine (Cr), and lipid profiles showed non-significant higher levels in UA2 group. In regression analysis, UA showed positive relations with WBCs (P = 0.003), NP (P = 0.002), Ur (P = 0.01), Phos (P <0.0001), TG (P = 0.01), and Chol (P = 0.02). UA showed negative relations with HDL (P= 0.002), and LP (P = 0.002). There was no correlation between UA and Hb even after subgroup analysis based on GFR and cut-off values of UA.

Conclusion

This study supported the inflammatory background associated with hyperuricemia. UA correlated with lipids profile in CKD-patients stages 3–5. There was no relation between UA and Hb in CKD patients in addition to previous conflicting data, future studies were required to establish this relationship.

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CKD 3-5期患者高尿酸血症的相关因素及其与血红蛋白的关系：来自叙利亚的横断面研究

背景：高尿酸血症和贫血与慢性肾脏疾病（CKD）患者的几种合并症有关。本研究旨在确定3-5期CKD样本中尿酸（UA）的相关因素以及UA与血红蛋白（Hb）的关系。方法横断面研究纳入198例患者。高尿酸血症定义为男性UA水平为7mg /dL，女性UA水平为6mg /dL，而贫血定义为Hb<；11.5 g / dL。比较两个UA组[正常UA组（UA1）和高尿酸血症组（UA2）]的数据。我们使用线性回归来确定UA与变量之间的关系。结果55.5%的患者报告高尿酸血症，其中男性和老年患者UA水平较高。UA2组白细胞、中性粒细胞百分比（NP）和磷（phos）水平较高(P = 0.005、0.03和0.002；淋巴细胞百分比（LP）较低（P = 0.04）。此外，UA2组尿素（Ur）、肌酐（Cr）和血脂水平均无显著升高。在回归分析中，UA与wbc （P = 0.003）、NP （P = 0.002）、Ur （P = 0.01）、Phos （P <0.0001）、TG （P = 0.01）、Chol （P = 0.02）呈正相关。UA与HDL （P= 0.002）、LP （P= 0.002）呈负相关。即使基于GFR和UA的临界值进行亚组分析，UA和Hb之间也没有相关性。结论本研究支持炎症背景与高尿酸血症相关。UA与ckd患者3-5期的脂质谱相关。在CKD患者中UA和Hb之间没有相关性，除了之前的数据冲突，需要未来的研究来建立这种关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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