Clinical Nutrition Open Science最新文献

{"title":"Mediterranean diet components and dry eye disease: Current evidence and mechanistic insights","authors":"Oveis Ahmadzadeh ,&nbsp;Dorsa Ghafouri ,&nbsp;Mahdi Shadnoush ,&nbsp;Pegah Samani ,&nbsp;Abasat Mirzaei ,&nbsp;Zeinab Javid ,&nbsp;Elham Ghorbani ,&nbsp;Mohammad Moradiani Moradabadi ,&nbsp;Ghazal Zolfaghari ,&nbsp;Shamimeh Arabgol ,&nbsp;Ronak Borzooei ,&nbsp;Parichehr Darvish ,&nbsp;Sahar Jafari Karegar","doi":"10.1016/j.nutos.2026.100625","DOIUrl":"10.1016/j.nutos.2026.100625","url":null,"abstract":"<div><h3>Background</h3><div>Dry eye disease (DED) is multifactorial-disorder characterized by tear film instability, ocular surface inflammation, and bothersome symptoms that impair quality of life. Diet-based strategies are increasingly explored as adjuncts to standard care.</div></div><div><h3>Methods</h3><div>We performed a narrative synthesis of clinical and pre-clinical studies evaluating MedDiet components or patterns in relation to DED outcomes.</div></div><div><h3>Results</h3><div>Multiple clinical studies suggest that omega-3 intake can improve tear break-up time (TBUT), Schirmer wetting, and Ocular Surface Disease Index (OSDI) scores in subsets of patients; however, some major trials, particularly those using active placebos such as olive oil, have reported no significant benefit of omega-3 supplementation over control. Components of olive oil or other aspects of the MedDiet can exhibit anti-inflammatory effects, neutralize free radicals, and stabilize the tear film. Antioxidant vitamins, carotenoids, and other components of the MedDiet can help preserve the integrity of the epithelial layer and reduce oxidative stress in tears. Vitamin D can support barrier layer proteins and maintain the balance between T helper 17 cells (Th17) and regulatory T cells (Treg), with rapid associations observed between vitamin D levels and dry eye disease (DED) symptoms, as well as some early outcome studies. Evidence for the MedDiet as a whole is weak, while stronger evidence exists for its individual components, although this varies by concentration, duration of administration, patient population, and control group.</div></div><div><h3>Conclusion</h3><div>Components of the MedDiet show promise in managing DED, particularly in specific DED phenotypes, but further trials with standardized outcomes are needed to confirm these findings.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenteral nutrition in the ICU","authors":"Annika Reintam Blaser ,&nbsp;Ronan Thibault ,&nbsp;Kaspar F. Bachmann","doi":"10.1016/j.nutos.2026.100635","DOIUrl":"10.1016/j.nutos.2026.100635","url":null,"abstract":"<div><div>This review was undertaken to summarize the current understanding of parenteral nutrition (PN) use in intensive care units (ICUs).</div><div>Based on available literature, roughly 15% of patients receive PN in the ICU. However, PN is not uniformly defined regarding its composition, leading to variable definitions used in clinical practice and studies.</div><div>There seems to be consensus on the absolute contraindications for enteral nutrition, which can then be seen as indications for parenteral nutrition. However, guidelines provide variable recommendations on the dosage and timing for initiating PN with entirely different recommendations regarding supplemental PN.</div><div>PN is associated with complications that must be prevented by following Good Clinical Practices, including considerations of the indications and ongoing monitoring.</div><div>A consensus on the definition of PN should be established to unify future studies. Development of tools for monitoring of metabolic processes and gastrointestinal function is warranted to better design future studies using different routes of nutrition.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100635"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ubiquinol on metabolic profile in prediabetic patients: A randomized, double-blinded, placebo-controlled pilot study","authors":"Pasita Palakornkitti ,&nbsp;Romun Leaovitavat ,&nbsp;Paphitchaya Thetsana ,&nbsp;Patana Teng-umnuay","doi":"10.1016/j.nutos.2026.100627","DOIUrl":"10.1016/j.nutos.2026.100627","url":null,"abstract":"<div><h3>Background/objectives</h3><div>Prediabetes not only increase the risk of developing diabetes, but it is also associated with the development of cardiovascular disease, chronic kidney disease, neuropathy, and retinopathy. Oxidative stress is a well-known contributor to its pathogenesis. This study aimed to examine the potential benefit effect of ubiquinol supplementation, a lipophilic antioxidant, on metabolic profile in prediabetic patients.</div></div><div><h3>Methods</h3><div>This prospective, randomized, double-blind, placebo-controlled pilot study enrolled 20 adults with impaired fasting plasma glucose (FPG), who were randomly assigned to receive ubiquinol (100 mg per day) or placebo. Metabolic profile including FPG, hemoglobin A1C (HbA1C), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) was assessed after 12-week treatment period. Between-group differences were analyzed according to the intention-to-treat principle, with effect sizes calculated to estimate the magnitude of observed effects.</div></div><div><h3>Results</h3><div>HOMA-IR was significantly lower in ubiquinol group compared to placebo group at week 12 (<em>P</em> = 0.028), with a moderate effect size (r =0.490). Median (range) HOMA-IR reduced from 2.23 (0.97) to 1.66 (0.39) for ubiquinol group while increased from 2.20 (0.90) to 2.35 (1.90) for placebo group. No significant difference in other outcome was reported. However, moderate-to-large effect sizes were observed for FPG, HbA1C, and fasting insulin.</div></div><div><h3>Conclusions</h3><div>Daily supplementation of 100-mg ubiquinol for 12 weeks improves insulin sensitivity for prediabetic patients with a favorable safety profile. The observed effect sizes support further investigation in larger, adequately powered trials to confirm the metabolic effects of ubiquinol.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100627"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146070926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary randomized controlled trial of a ginger-containing, clear, fat-free oral nutritional Supplement for chemotherapy-induced nausea and nutritional outcomes","authors":"Rie Tsutsumi ,&nbsp;Soshi Narasaki ,&nbsp;Yousuke T. Horikawa ,&nbsp;Yuna Izumi-Mishima ,&nbsp;Sonoko Yasui-Yamada ,&nbsp;Kazuhiro Nomura ,&nbsp;Hiroshi Sakaue ,&nbsp;Yasuo M. Tsutsumi","doi":"10.1016/j.nutos.2025.12.011","DOIUrl":"10.1016/j.nutos.2025.12.011","url":null,"abstract":"<div><h3>Purpose</h3><div>Chemotherapy-induced nausea and vomiting (CINV) is a serious side effect, affecting approximately 40% of cancer patients and often hindering their ability to continue treatment. In this study, we evaluated the efficacy of an oral nutrition supplement (ONS) designed to decrease patients experiencing CINV.</div></div><div><h3>Methods</h3><div>A total of 98 patients were assessed for eligibility, and 75 patients were prospectively and randomly assigned to one of three groups: the control group without ONS (Control; n = 25), a fat-free clear ONS including ginger extract group (Ginger ONS; n = 25), or the Conventional ONS group (Conv ONS; n = 25). Data collection included Numerical Rating Scale (NRS) for nausea, number of vomiting episodes, use of antiemetic drugs, blood biochemical tests, serum substance P levels, Quality of Life (QOL) Assessment, and dietary intake.</div></div><div><h3>Results</h3><div>NRS for nausea scores after the second cycle of chemotherapy were 7.8 ± 1.8 in the Control group, 3.5 ± 1.4 in the Ginger ONS group, and 5.7 ± 1.9 in the Conv ONS group. Substance P levels decreased significantly in the Ginger ONS group compared to the Conv ONS and Control groups. In addition, the Ginger ONS group showed a significant improvement in energy and protein intake. Body weight and lean body mass were also improved. Finally, QOL was significantly improved in the Ginger ONS group following the second cycle of chemotherapy (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Taken together, these data suggest that Ginger ONS is associated with improvements in nausea and energy/protein intake following chemotherapy. It is possible that comprehensive differences in nutritional composition—including the ginger extract, the amount and quality of protein, absence of fat, palatability, etc.—may have contributed to the observed outcomes.</div></div><div><h3>Trial Registry</h3><div><span><span>https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000060201</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100617"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146070927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of animal source foods (ASFs) consumption among Somali children aged 6–23 months; evidence from the 2020 Somalia demographic and health survey; a multilevel mixed effect model analysis","authors":"Abdifatah Ibrahim Mouse ,&nbsp;Abdisalam Hassan Muse","doi":"10.1016/j.nutos.2026.100631","DOIUrl":"10.1016/j.nutos.2026.100631","url":null,"abstract":"<div><h3>Background</h3><div>Animal Source Foods (ASFs) provide high-quality protein and essential micronutrients critical for physical growth and cognitive development in young children. Inadequate consumption of ASFs during the complementary feeding period (6–23 months) contributes significantly to stunting and micronutrient deficiencies in developing regions. Despite the high burden of malnutrition in Somalia, there is a paucity of nationally representative data regarding ASF consumption patterns and their determinants among Somali children.</div></div><div><h3>Aims</h3><div>This study aimed to determine the magnitude of ASF consumption and identify individual and community-level determinants among children aged 6–23 months in Somalia.</div></div><div><h3>Methods and Materials</h3><div>A secondary analysis was conducted using data from the 2020 Somalia Demographic and Health Survey (SDHS). The study included a sample of 2,097 children aged 6–23 months. The outcome variable was the consumption of any ASF (meat, eggs, fish, organ meat, or dairy) in the 24 hours preceding the survey. A multilevel mixed-effects logistic regression model was fitted to identify significant predictors, reporting Adjusted Odds Ratios (AOR) with 95% Confidence Intervals (CI).</div></div><div><h3>Results</h3><div>The overall prevalence of ASF consumption was 64.9% (95% CI: 62.8–66.9%). However, consumption was heavily skewed towards fresh milk (45.5%), while intake of meat (11.2%), eggs (7%), and fish (4.7%) was low. Multivariable analysis revealed that children with media exposure (AOR = 1.60; 95% CI: 1.03–2.50) and those not currently breastfeeding (AOR = 1.75; 95% CI: 1.41–2.17) had higher odds of ASF consumption. Conversely, lack of maternal mobile phone ownership (AOR = 0.76; 95% CI: 0.58–0.99) and husband unemployment (AOR = 0.69; 95% CI: 0.55–0.86) were associated with lower consumption. Paradoxically, children from wealthier households (fourth quintile) had lower odds of consuming ASFs compared to the poorest households (AOR = 0.60; 95% CI: 0.43–0.85).</div></div><div><h3>Conclusion</h3><div>While the prevalence of ASF consumption appears moderately high, it is qualitatively limited by a heavy reliance on milk and a lack of solid animal proteins like meat and eggs. Socioeconomic factors, media access, and breastfeeding status significantly influence consumption patterns. Interventions should focus on promoting dietary diversification beyond milk through mass media campaigns and economic empowerment initiatives.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100631"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of zinc supplementation on serum concentration of lipid profile among children and adolescents: A systematic review on randomized controlled trials","authors":"Ali Gholami ,&nbsp;Fatemeh Azizi-Soleiman ,&nbsp;Mitra Hariri","doi":"10.1016/j.nutos.2026.100629","DOIUrl":"10.1016/j.nutos.2026.100629","url":null,"abstract":"<div><h3>Background</h3><div>New evidence suggests that zinc supplementation may significantly influence serum lipid profile levels and vascular health in children and adolescents. Therefore, this systematic review aims to investigate and summarize published data regarding the effects of zinc supplementation on lipid profiles in children and adolescents.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across multiple databases, including the Cochrane Library, <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, ISI Web of Science, Scopus, and PubMed, up to May 2025. Search terms related to zinc, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG), children, adolescents, and clinical trials were identified using both Medical Subject Headings (MeSH) and non-MeSH terms. The search strategy employed asterisks, parentheses, quotation marks, and Boolean operators (AND/OR) to optimize retrieval of relevant studies.</div></div><div><h3>Results</h3><div>A total of five studies were included in this systematic review. Serum TG, LDL-C, and HDL-C levels were assessed in four studies, and TC levels in five studies. TC decreased in one study. TG and LDL-C levels showed significant reductions compared with placebo in two studies. A significant increase in HDL-C levels was observed in one study.</div></div><div><h3>Conclusion</h3><div>Zinc supplementation may be effective in improving lipid profiles among children and adolescents. However, further well-designed randomized clinical trials involving children and adolescents with varying health conditions, larger sample sizes, different zinc dosages, and longer follow-up periods are strongly recommended to confirm the effectiveness of zinc supplementation in this population.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100629"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting energy expenditure is not defined by bowel function among patients with intestinal failure","authors":"Caroline Amalie Krag ,&nbsp;Signe Amalie Schaaning Heuckendorff ,&nbsp;Alberte Schneevoigt Højrup ,&nbsp;Caroline Bang Pedersen ,&nbsp;Sabina Mikkelsen ,&nbsp;Marianne Køhler ,&nbsp;Henrik Højgaard Rasmussen ,&nbsp;Mette Holst","doi":"10.1016/j.nutos.2026.100630","DOIUrl":"10.1016/j.nutos.2026.100630","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Resting energy expenditure (REE) is a critical parameter for assessing energy requirements in patients with chronic intestinal failure (CIF). This study aimed to investigate the influence of intestinal functionality, defined by the need for parenteral nutrition (PN), on REE and to evaluate the accuracy of Harris-Benedict equation (HB-equation) used to estimate REE (eREE) in individuals with CIF.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted among patients diagnosed with CIF. Data collected was demographic information, body composition measured by bioelectric impedance analysis, measured REE (mREE) by indirect calorimetry and data from the patients’ medical records like pathophysiological mechanisms, underlying diseases, receiving PN or not, information related to nutritional risk and blood samples (CRP and albumin). Furthermore, eREE was calculated by the HB-equation.</div></div><div><h3>Results</h3><div>Overall, 201 patients were included (mean age: 61.8±14.8 years, sex: 65.0% female). There was a significant difference between patients with short bowel syndrome, other underlying pathophysiological mechanisms and other diseases <em>P</em>&lt;0.001. No significant difference was observed in overall mREE between patients receiving PN and those not receiving PN. However, significant differences were observed for REE/kg body weight, REE/kg muscle mass, and REE/kg fat free mass between patients receiving PN and those not receiving PN. REE was lower, when estimated compared to measured (<em>P</em>=0.003), and the group with SBS, cancer and those not receiving PN, had lower REE when estimated compared to measured (<em>P</em>&lt;0.05).</div></div><div><h3>Conclusion</h3><div>Intestinal functionality had no influence on REE, however REE/kg mass was higher in the PN-group for body weight, muscle mass and fat free mass. When comparing the HB-equation with IC, eREE was overall lower compared to mREE. This study emphasizes the need for more accurate equations to estimate REE in CIF patients, highlighting that IC is essential for precise measurement at present time.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100630"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thigh ultrasound is a valid measurement for sarcopenia and fat mass analysis in patients with cirrhosis","authors":"Reza Saeidi ,&nbsp;Neasa Mc Gettigan ,&nbsp;Marian Hanley ,&nbsp;Martina Morrin ,&nbsp;John Ryan ,&nbsp;Karen Boland","doi":"10.1016/j.nutos.2026.100628","DOIUrl":"10.1016/j.nutos.2026.100628","url":null,"abstract":"<div><h3>Aim and background</h3><div>Sarcopenia, defined as reduced muscle mass and strength, is associated with poor outcomes in cirrhosis. Severe sarcopenia includes low performance status. While CT imaging is the standard for assessing muscle mass, anterior thigh ultrasound (TUS) may offer a low-cost, bedside alternative. This study aimed to validate TUS—measuring total muscle thickness (TMT) and superficial fat (SF)—against bioelectrical impedance analysis (BIA), and to explore its relationship with the Liver Frailty Index (LFI).</div></div><div><h3>Method</h3><div>In this cross-sectional study, patients with cirrhosis were recruited from hepatology clinic and compared to healthy controls. TMT was measured at the midpoint between the patella and anterior superior iliac spine using B-mode ultrasound with minimal probe pressure. BIA (SECA mBCA 525) was the reference standard. Sarcopenia was diagnosed using the Sergi equation. Functional metrics (handgrip, sit-to-stand), LFI, and body fat percentage were also assessed.</div></div><div><h3>Results</h3><div>A total of 124 participants were included (87 cirrhotic, 37 controls). TMT ≤ 3.47 cm in men and ≤ 2.94 cm in women predicted sarcopenia with AUCs of 0.90 and 0.83, respectively. SF correlated with fat mass index in both sexes (rho = 0.61 in males and rho = 0.57 in females, <em>P</em> &lt; 0.001). LFI negatively correlated with TMT (rho = - 0.32, <em>P</em> = 0.002). No correlation was found between TMT or LFI and MELD or Child-Pugh scores.</div></div><div><h3>Conclusion</h3><div>TUS is a valid, bedside tool to detect sarcopenia and frailty in cirrhosis. TMT correlates with reduced muscle function, supporting its clinical utility in identifying high-risk patients.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100628"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of antioxidant supplementation containing selenium and vitamin E on male infertility: A systematic review and meta-analysis","authors":"Behnaz Sadeghzadeh Oskouei ,&nbsp;Parnian Rahimi ,&nbsp;Niusha Azimzadeh ,&nbsp;Azizeh Farshbaf-Khalili ,&nbsp;Soraya Babaie ,&nbsp;Aliasghar Khakpaki","doi":"10.1016/j.nutos.2026.100632","DOIUrl":"10.1016/j.nutos.2026.100632","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies highlight the impact of oxidative stress on sperm quality and male fertility. Given the potential antioxidant effects of selenium and vitamin E, this systematic review and meta-analysis assessed the impact of antioxidant supplementation containing selenium and vitamin E (Se+Vit E) on male infertility.</div></div><div><h3>Methods</h3><div>A systematic search (Web of Science, Medline, Embase, Scopus, ProQuest, Cochrane Library through April 2025) identified 19 studies (11 single-arm, 7 randomized controlled trials (RCTs), 1 non-randomized) evaluating sperm quality, oxidative stress, and pregnancy rates. Methodological quality was assessed using Cochrane guidelines.</div></div><div><h3>Results</h3><div>Meta-analysis of data from 8 studies (736 participants) revealed that dual Se+Vit E supplementation enhanced motility (mean difference [MD]: 13.56%, 95%CI: 0.16–0.81; <em>P</em>=0.001; I²=41%), normal morphology (MD: 0.69%, 95%CI: 0.27–1.11; <em>P</em>=0.001; I²=0%), and vitality (MD: 23.24%, 95%CI: 16.66–29.82; <em>P</em>&lt;0.00001; I²=41%). The sperm motility also increased in total (dual Se+Vit E in addition to antioxidants containing Se+Vit E) (13.56%, 95%CI: 0.16–0.81; <em>P</em>=0.001; I²=41%). No significant effects were observed on semen volume, sperm count, sperm concentration, or DNA fragmentation index (DFI) following dual Se+Vit E supplementation or antioxidants containing Se+Vit E (<em>P</em>&gt;0.05). Single-arm studies reported some benefits in motility, morphology, concentration, and DFI. Antioxidant regimens including Se+Vit E reduced seminal reactive oxygen species (ROS) and apoptotic markers. Pregnancy data were limited and inconclusive.</div></div><div><h3>Conclusion</h3><div>Antioxidants containing Se+Vit E may improve sperm motility. Moreover, supplementation with dual Se+Vit E can enhance sperm motility, normal morphology, and vitality. Due to the heterogeneity of studies, further large and high-quality trials with standardized protocols and critical endpoints like pregnancy rates are required.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100632"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-erythrocyte creatine, plasma creatine and long-term outcomes in stable kidney transplant recipients: Results from the TransplantLines Biobank and Cohort study","authors":"Caecilia S.E. Doorenbos ,&nbsp;Adrian Post ,&nbsp;Yvonne van der Veen ,&nbsp;Casper F.M. Franssen ,&nbsp;Michele F. Eisenga ,&nbsp;Robin P.F. Dullaart ,&nbsp;Gerjan Navis ,&nbsp;Qinglin Wu ,&nbsp;Jessica M. Gonzalez-Delgado ,&nbsp;Margery A. Connelly ,&nbsp;Stephan J.L. Bakker","doi":"10.1016/j.nutos.2025.11.013","DOIUrl":"10.1016/j.nutos.2025.11.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Kidney transplant recipients (KTR) have excess mortality compared to the general population and show altered creatine homeostasis. Creatine, an endogenous nitrogenous compound, is essential for energy metabolism. We investigated determinants of circulating creatine and their sex-specific associations with mortality in KTR.</div></div><div><h3>Methods</h3><div>Intra-erythrocyte and plasma creatine were quantified by nuclear magnetic resonance in samples from KTR and living kidney donors (healthy controls) from the TransplantLines Biobank and Cohort study (ClinicalTrials.gov: NCT03272841). Determinants of intra-erythrocyte and plasma creatine were assessed using linear regression; associations with mortality were evaluated with Cox regression.</div></div><div><h3>Results</h3><div>815 KTR and 53 healthy controls were included. Compared with controls, KTR had higher intra-erythrocyte but lower plasma creatine, with women having higher concentrations of each in both groups. In KTR, plasma creatine, BMI, erythrocyte count, reticulocyte count, lactate dehydrogenase, and erythropoietin use were positively associated with intra-erythrocyte creatine, whereas hemoglobin, haptoglobin, ferritin, transferrin saturation, proliferation inhibitor use were negatively associated. In univariable analyses, higher intra-erythrocyte creatine was associated with higher risk of mortality in male KTR (HR: 2.30 (1.50; 3.54), <em>P</em>&lt;0.001), with a weaker, nonsignificant trend in female KTR (HR: 1.51 (0.76; 3.02), <em>P</em>=0.23). Furthermore, higher plasma creatine was associated with higher risk of mortality in male KTR (HR: 1.36 (1.07; 1.73), <em>P</em>=0.01), but not in female KTR (HR: 0.94 (0.68; 1.28), <em>P</em>=0.68). These associations persisted after adjustment for potential confounders.</div></div><div><h3>Conclusion</h3><div>KTR have increased intra-erythrocyte and decreased plasma creatine compared with healthy controls. Intra-erythrocyte creatine was linked to markers of erythrocyte turnover, suggesting potential mechanisms. Elevated intra-erythrocyte and plasma creatine were associated with higher mortality in male, but not female, KTR. These findings highlight the need to further explore sex-specific mechanisms underlying creatine metabolism and clinical outcomes in KTR.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100606"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}