Clinical Nutrition Open Science最新文献

{"title":"Corrigendum to “Are ultra-processed plant-based meats better than the alternative?” [Clin Nutr Open Sci 61 (2025) 241–252]","authors":"Michael Greger","doi":"10.1016/j.nutos.2025.07.005","DOIUrl":"10.1016/j.nutos.2025.07.005","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"63 ","pages":"Page 11"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic role of malnutrition in pulmonary hypertension","authors":"Arif Albulushi ,&nbsp;Morgan Newlun ,&nbsp;Amanda Sooter ,&nbsp;Lauren Grieb ,&nbsp;Radha Kanneganti Perue","doi":"10.1016/j.nutos.2025.07.002","DOIUrl":"10.1016/j.nutos.2025.07.002","url":null,"abstract":"<div><h3>Background</h3><div>Malnutrition is a common yet underrecognized comorbidity in pulmonary hypertension (PH) and may adversely affect patient outcomes. This study evaluated the prognostic impact of malnutrition in PH patients.</div></div><div><h3>Methods</h3><div>A retrospective cohort of 350 PH patients treated at a U.S. tertiary center between January 2017 and December 2023 was analyzed. Patients were stratified into four groups based on nutritional status. Survival analysis using Kaplan-Meier estimates and multivariable Cox regression identified predictors of mortality.</div></div><div><h3>Results</h3><div>Of the 350 patients, 22.8% had severe malnutrition, which was significantly associated with lower median survival (18 vs. 36 months, <em>P</em> &lt; 0.01). In adjusted models, severe malnutrition independently predicted increased mortality (HR: 2.5; 95% CI: 1.8–3.6; <em>P</em> &lt; 0.01). Other predictors included age (HR: 1.03), NYHA class III-IV (HR: 1.8), elevated pulmonary arterial pressure (HR: 1.05), low serum albumin (HR: 0.6), and comorbidities (HR: 1.4).</div></div><div><h3>Conclusion</h3><div>Severe malnutrition is a strong, independent predictor of mortality in PH patients. Routine nutritional assessment and early intervention may improve survival and clinical outcomes in this high-risk population.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"63 ","pages":"Pages 1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of lead acetate-induced testicular dysfunction in male wistar rats: A possible role for combined extracts of Syzygium aromaticum and Xylopia aethiopica seeds","authors":"Emmanuel Nnaemeka Uhuo,&nbsp;Paulinus Chinedu Nwuke,&nbsp;Chiemeziem Adnma Obike,&nbsp;Prince Ogochukwu Alaebo,&nbsp;Becky Chinyere Odili","doi":"10.1016/j.nutos.2025.06.006","DOIUrl":"10.1016/j.nutos.2025.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Lead acetate poisoning induces testicular dysfunction through the enhancement of oxidative stress and morphological abnormalities in the testes. Phytoconstituents exhibit antioxidative effects that enhance sperm parameters. This study sought to evaluate the efficacy of a combination extract of <em>Syzygium aromaticum</em> and <em>Xylopia aethiopica</em> seeds (1:1 ratio) in mitigating lead-induced testicular dysfunction in Wistar rats.</div></div><div><h3>Methods</h3><div>Twenty male Wistar rats were divided into four groups (n=5): (i) Normal Control (NC), (ii) Lead Acetate Control (PbC), (iii) Lead Acetate + 200 mg/Kg (Pb-200), and (iv) Lead Acetate + 400 mg/Kg (Pb-400). Groups ii-iv received 60 mg/kg of lead acetate orally, followed by the administration of the extract after a 30-minute interval per day for 28 days. Subsequently, relative weight, testicular weight, sperm parameters, reproductive hormones, malondialdehyde, antioxidant enzymes, and lipid profile were assessed.</div></div><div><h3>Results</h3><div>Testicular and associated weight exhibited a substantial reduction (<em>P</em>&lt;0.05) in NC compared to PbC. A comparable trend was observed in Pb-200 and Pb-400 relative to NC. The percentage of aberrant morphology considerably rose (<em>P</em>&lt;0.05) in PbC and decreased in Pb-200 and Pb-400. A reduction in pH was observed in PbC compared to NC and the treatment groups. Sperm count, motility, and viability were decreased (<em>P</em>&lt;0.05) in PbC compared to Pb-200 and Pb-400.Likewise, serum testosterone, follicle-stimulating hormone, luteinizing hormone, and glutathione exhibited a similar pattern. A notable reduction (<em>P</em>&lt;0.05) in malondialdehyde, triacylglycerol, cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels was seen in PbC compared to the treatment groups and NC. A reduction in these parameters was recorded in Pb-400 compared to Pb-200. Moreover, the activities of superoxide dismutase, catalase, and glutathione peroxidase exhibited a substantial reduction (<em>P</em>&lt;0.05) in PbC compared to Pb-200, Pb-400, and NC. The activity of these enzymes was elevated in Pb-400 relative to Pb-200.</div></div><div><h3>Conclusion</h3><div>The combined extracts of S. <em>aromaticum</em> and <em>X. aethiopica</em> seeds mitigate lead acetate-induced testicular damage in Wistar rats through their antioxidant capabilities.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 246-264"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional interventions and barriers for patients early after burn injury: A retrospective evaluation of medical records","authors":"Josefin Dimander ,&nbsp;Agneta Andersson ,&nbsp;Fredrik Huss ,&nbsp;Catarina Lindqvist","doi":"10.1016/j.nutos.2025.06.007","DOIUrl":"10.1016/j.nutos.2025.06.007","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Inadequate intake and barriers to nutritional therapy are challenges in burn care. Post-burn injury nutritional care practices are rarely reported, particularly after minor injuries. The aim of this study was to describe nutritional interventions, identify barriers to nutritional intervention, and compare the documentation of nutrition for patients after minor and major burn injuries.</div></div><div><h3>Methods</h3><div>A retrospective single-centre medical record review was conducted on patients aged 18 and older who were admitted for more than 72 h between 2017 and 2019 at one of Sweden's two national burn centres. A content analysis and descriptive statistics were used to analyse the data, and differences were explored between patients with minor and major burn injuries.</div></div><div><h3>Results</h3><div>A total of 134 patients were included in the study: 90 patients had minor burn injuries (mean total burn surface area (TBSA) 8.1 % ± 5.0), and 44 patients had major burn injuries (mean TBSA 37.8 % ± 17.2). Nutritional supplement therapy (93 %) and nutrition prescription (91 %) were the most common interventions. Interventions targeting meals and snacks (43 %) and meal support (40 %), were documented less frequently. Fasting (93 %) and gastrointestinal symptoms (49 %) were the most common barriers.</div><div>Significantly more interventions (including enteral/parenteral nutrition, and vitamin/mineral supplementation) and barriers (primarily related to enteral nutrition and fasting) were documented for patients with major burn injuries.</div></div><div><h3>Conclusion</h3><div>This study concludes that while most patients have oral intake, vitamin and mineral supplementation and medical nutritional therapy were more frequently documented than meal/snack interventions and meal support. The lack of dietary interventions, whether unperformed or undocumented, needs further investigation. Frequent documentation of barriers to nutritional interventions suggests that patients post-burn injury are at risk of inadequate energy and protein intake. Therefore, emphasising nutritional therapy and its documentation in post-burn care is crucial, regardless of burn severity.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 218-232"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of central parenteral nutrition with a 1:1 ratio of n-3/n-6 polyunsaturated fatty acids in postsurgical gastric cancer patients: A pilot randomized controlled trial","authors":"Ju-Hee Lee ,&nbsp;Sang-Yong Son ,&nbsp;Dong-Seok Han ,&nbsp;Han Hong Lee ,&nbsp;Hoon Hur ,&nbsp;Seung Wan Ryu ,&nbsp;Do Joong Park","doi":"10.1016/j.nutos.2025.06.008","DOIUrl":"10.1016/j.nutos.2025.06.008","url":null,"abstract":"<div><h3>Background</h3><div>N-3 polyunsaturated fatty acids (PUFAs) have been reported to exert clinical benefits including anti-inflammatory effects, immune modulation, and improved postoperative recovery. This study aimed to investigate the effects of central parenteral nutrition (CPN) with a 1:1 ratio of n-3/n-6 PUFAs on postoperative morbidity and lipid profile in gastric cancer patients undergoing gastrectomy.</div></div><div><h3>Methods</h3><div>Sixty gastric cancer patients undergoing elective gastrectomy were randomly assigned to the experimental (n=31) and control (n=29) groups. The experimental group received CPN with a 1:1 ratio of n-3/n-6 PUFAs and taurine during the postoperative nil-per-os period (days 1–3), while the control group received CPN with a 1:2 ratio of n-3/n-6 PUFAs. Adverse drug reactions, overall adverse events, nitrogen balance, inflammatory indicators (C-reactive protein, interleukin-6, tumor necrosis factor-α), nutrition parameters (hemoglobin, total protein, albumin, prealbumin, transferrin), and fatty acid parameters (linoleic acid [LA, n-6], arachidonic acid [n-6], eicosapentaenoic acid [EPA, n-3], docosahexaenoic acid [DHA, n-3]) were compared.</div></div><div><h3>Results</h3><div>No adverse drug reactions were observed in either group. Overall adverse event rates were similar between the groups. No significant differences were observed between the groups in changes in nutritional indicators or inflammatory markers. While the experimental group showed a trend toward improvement in nitrogen balance compared to the control group (0.63±2.37 vs. -1.24±4.57 g/day), this difference did not remain statistically significant after adjustment for multiple comparisons. Among the measured fatty acids, only the increase in EPA levels reached statistical significance after correction (57.50±31.45 μg/mL vs. 35.79±14.94 μg/mL, <em>P</em>&lt;0.001). Increases in DHA levels and attenuation of LA increase showed favorable trends in the experimental group but were not statistically significant when accounting for multiple testing.</div></div><div><h3>Conclusion</h3><div>Parenteral nutrition with a 1:1 ratio of n-3/n-6 PUFAs appears to be safe and may help modify fatty acid profiles in postoperative gastric cancer patients. Further large-scale studies are needed to validate these findings and evaluate their clinical significance.</div></div><div><h3>Trial registration number and date</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (NCT05299099); March 28, 2022.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 233-245"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health assessment of 4–13 years students living in a rural Andean region: The EVANES study design protocol","authors":"Fátima Morales ,&nbsp;Marcela Guerendiain","doi":"10.1016/j.nutos.2025.06.003","DOIUrl":"10.1016/j.nutos.2025.06.003","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>In Ecuador, stunting and overweight are the main nutritional problems identified at school age in the indigenous population, associated with infectious diseases and diarrhoea. The Andean region has the largest indigenous population in the country, which suffers from inequality and poverty, especially those inhabiting rural areas. Clinical studies have shown a high infection vulnerability of rural populations. Therefore, we aim to evaluate nutritional status according to dietary intake, intestinal parasitic infections, household and environmental conditions, ant their relation with cognitive development of schoolchildren in rural highlands of Ecuador in order to develop prevention and health promotion programmes adapted to the needs of these children and their families.</div></div><div><h3>Methods</h3><div>The EVANES study is a multi- and interdisciplinary approach designed to evaluate the dietary intake, anthropometric parameters, intestinal parasitic infections, hygienic-sanitary and environmental conditions and cognitive development of Ecuadorian schoolchildren.</div></div><div><h3>Results</h3><div>This exhaustive assessment may be useful for: identifying nutritional issues, establishing health programmes for disease prevention and health promotion, clarifying the aetiology of stunting in the indigenous population, and defining reference patterns for the diagnosis of anaemia in the highlands in childhood.</div></div><div><h3>Conclusions</h3><div>The EVANES study could be a model protocol for other areas of Ecuador and countries, and can contribute to improving the health and development of children in Latin American and highland countries. It is expected to contribute to the scientific community with unique insights into the health status of rural indigenous schoolchildren living at high altitude, in order to develop appropriate health programmes and policies for disease prevention and health promotion in these populations.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 189-207"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of ultra-processed foods on the gut microbiome and gastrointestinal complaints after bariatric surgery: A narrative review","authors":"Hendrika J.M. Smelt ,&nbsp;Sjaak Pouwels ,&nbsp;Christine Stier ,&nbsp;Johannes F. Smulders","doi":"10.1016/j.nutos.2025.06.005","DOIUrl":"10.1016/j.nutos.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div>Bariatric surgery (BS) leads to malabsorption trough alterations of the gastrointestinal tract, which can result in changes in the gut microbiome (GM). Disturbances in the GM are associated with disruptions in nutrient digestion and absorption, regulation of intestinal motility, and maintenance of intestinal epithelium integrity. GM diversity significantly changes after BS but is not fully restored.</div></div><div><h3>Goal of this review</h3><div>A significant number of patients also experience chronic, unexplained abdominal complaints. It is presumed that food intake may play a more substantial role than previously thought. This review provides an overview of the (nutritional) factors that may contribute to abdominal pain after bariatric surgery.</div></div><div><h3>Conclusion</h3><div>Worldwide, many ultra-processed foods are consumed, which disrupt the GM and likely contribute to gastrointestinal symptoms and exacerbate the chronic inflammatory process. However, the influence of these products on the development of gastrointestinal complaints after BS has not yet been studied. This should be the focus for future research.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 208-217"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional management of survivors of critical illness: The clinical pharmacists' role","authors":"Zenzi Rosseel ,&nbsp;Stephanie C.M. Wuyts ,&nbsp;Marjoleine Desmedt ,&nbsp;Sandrina von Winckelmann ,&nbsp;Elisabeth De Waele ,&nbsp;Claudine Ligneel ,&nbsp;Pieter-Jan Cortoos","doi":"10.1016/j.nutos.2025.06.002","DOIUrl":"10.1016/j.nutos.2025.06.002","url":null,"abstract":"<div><div>Critically ill patients face many challenges such as dysphagia leading to muscle loss and malnutrition. To prevent and treat malnutrition, ICU protocols from the European Society of Clinical Nutrition and Metabolism (ESPEN) and American Society of Parenteral and Enteral Nutrition (ASPEN) are established, available and implemented in ICU's, However, in the post-ICU phase, little literature is available evaluating the nutritional needs of those patients as well as the challenges they are facing. Artificial nutrition can be used to provide adequate nutrition, but in combination with various drugs such as prokinetics or analgesics drug side effects, drug-drug and drug-nutrition interactions may occur resulting in suboptimal nutritional therapy. To prevent these problems, clinical pharmacists can provide meaningful support. Clinical pharmacists are specialists in medication review and medication reconciliation guaranteeing adequate dosing, preventing side effects and checking for drug appropriateness. Through multidisciplinary collaboration, they are also often involved in nutritional support. The aim of this article was to review current literature regarding the roles of clinical pharmacists as well as providing insights in their future role in post-ICU nutritional care.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 127-138"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary biomarkers of ultra-processed foods: A narrative review","authors":"Thomas Scott Armstrong,&nbsp;Kaitlyn Delaney Chappell,&nbsp;Lekan Ajibulu,&nbsp;Karen Wong","doi":"10.1016/j.nutos.2025.06.001","DOIUrl":"10.1016/j.nutos.2025.06.001","url":null,"abstract":"<div><div>The rapidly increasing prevalence of ultra-processed foods (UPFs) in global diets necessitates a more comprehensive understanding of this food group's effects on health and disease. Nutritional biomarkers are critical for developing this understanding, as they provide an objective assessment of the body's response to UPF intake. Here, we critically assessed the findings of five studies-all of which were identified via a systematic search of the literature using stringent criteria and were focused on the biomarkers of UPFs. Based on the data extracted, we categorized UPF biomarkers into organic acids (including amino acids), lipids/lipid-like molecules, xenobiotic food components (specifically associated with UPFs), and other molecular compounds (dietary oxysterols, nucleotides, proteins, etc). These findings emphasized the importance of future studies concerning UPF and food processing techniques, while providing a succinct summary of the current biomarkers of UPFs in relevant literature.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 156-163"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of nutrition in various endocrine and metabolic diseases","authors":"Nanny Natalia Mulyani Soetedjo","doi":"10.1016/j.nutos.2025.05.015","DOIUrl":"10.1016/j.nutos.2025.05.015","url":null,"abstract":"<div><div>The endocrine system plays a central role in maintaining the body's homeostasis. Endocrine and metabolic disorders are complex and critical areas of healthcare, given their crucial role in regulating various body functions. The author presents nutritional therapy recommendations that can play an essential role in the management of endocrine and metabolic disorders, namely panhypopituitarism, adrenal fatigue, osteoporosis, obesity, dyslipidemia, hyperuricemia, aging, menopause and andropause, thyroid disorders, and diabetes, to provide a holistic understanding of the role of nutrition and improve the quality of life of patients with these conditions.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 164-188"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}