Clinical Nutrition Open Science最新文献

{"title":"Corrigendum to “Is the acid load of the diet related to esophageal cancer? A case-control study” [Clin Nutr Open Sci 61 (2025) 190–199]","authors":"Omid Nikpayam, Parmis Mirzaei, Golbon Sohrab, Amirmahdi Najafi, Reza Eghdam Zamiri, Alireza Ostadrahimi","doi":"10.1016/j.nutos.2026.100694","DOIUrl":"10.1016/j.nutos.2026.100694","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"68 ","pages":"Article 100694"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing immunonutrition evidence in clinical practice: A call for standardised mechanistic and outcome measures","authors":"Lusyana Gloria Doloksaribu, Jenni Lilis Siagian","doi":"10.1016/j.nutos.2026.100677","DOIUrl":"10.1016/j.nutos.2026.100677","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"68 ","pages":"Article 100677"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A preliminary randomized controlled trial of a ginger-containing, clear, fat-free oral nutritional supplement for chemotherapy-induced nausea and nutritional outcomes” [Clin Nutr Open Sci 66 (2026) 100617]","authors":"Rie Tsutsumi, Soshi Narasaki, Yousuke T. Horikawa, Yuna Izumi-Mishima, Sonoko Yasui-Yamada, Kazuhiro Nomura, Hiroshi Sakaue, Yasuo M. Tsutsumi","doi":"10.1016/j.nutos.2026.100693","DOIUrl":"10.1016/j.nutos.2026.100693","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"68 ","pages":"Article 100693"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional intake and physical status in older adults with obesity and probable sarcopenic obesity prior to hip and knee arthroplasty","authors":"Ellen Oosting ,&nbsp;Mirjam Holverda ,&nbsp;Jordi Elings ,&nbsp;Wouter van Helden ,&nbsp;Marco Mensink ,&nbsp;Johannes Zwerver","doi":"10.1016/j.nutos.2026.100680","DOIUrl":"10.1016/j.nutos.2026.100680","url":null,"abstract":"<div><h3>Background</h3><div>Malnutrition and sarcopenia are often overlooked in obese patients, despite their impact on surgical outcomes. In orthopedic care, nutritional risk is typically assessed using BMI or limited biomarkers, which may fail to appraise important deficits in diet, body composition and physical function.</div></div><div><h3>Objective</h3><div>To assess preoperative nutritional intake, body composition, and physical function in older adults with obesity and probable sarcopenic obesity awaiting hip or knee arthroplasty.</div></div><div><h3>Methods</h3><div>Obese patients (BMI ≥30 kg/m²) scheduled for total hip or knee arthroplasty (TKA, THA) were included. Nutritional intake was evaluated through three-day food diaries, body composition via DEXA, and physical function using standardized functional tests. Nutrient intake was compared with Dutch Recommended Daily Allowances and national references.</div></div><div><h3>Results</h3><div>The study population consisted of 21 women and 8 men (mean age 64 ±10, BMI 35 ±3, 69% TKA). Despite obesity, significant variation was observed in muscle mass, strength, physical performance, and dietary intake. Energy intake was below recommended levels for both men and women. Several key micronutrients (e.g., calcium, magnesium, vitamin B6) were frequently consumed at suboptimal levels. A case series of four representative patients (two women, two men) with BMI 30–35 kg/m² demonstrated substantial individual diversity in body composition and physical function.</div></div><div><h3>Conclusion</h3><div>Obese older patients awaiting arthroplasty show considerable heterogeneity in nutritional intake, body composition, and physical function. They cannot be considered as one homogeneous group. Comprehensive assessments beyond BMI and standard screening are needed to identify at-risk patients for developing surgical complications and guide targeted prehabilitation strategies.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"67 ","pages":"Article 100680"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth faltering and associated factors among pediatric cancer patients treated in Jimma Medical Center, Jimma, South West Ethiopia","authors":"Asfaw Gerbi ,&nbsp;Tefera Belachew ,&nbsp;Diriba Fufa ,&nbsp;Dessalegn Tamiru ,&nbsp;Urge Gerema ,&nbsp;Rabuma Sorsa ,&nbsp;Milkessa Tareke","doi":"10.1016/j.nutos.2026.100681","DOIUrl":"10.1016/j.nutos.2026.100681","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Malnutrition is an enormously common comorbidity among pediatric cancer patients. However, little is known about changes in the growth pattern and factors affecting the growth status in pediatric cancer patients. The purpose of this study was to retrospectively evaluate changes in the height-for-age Z-score (HAZ) and body mass index (BMI)-for-age Z-score (BAZ) between the time of cancer diagnosis and six months after treatment initiation among pediatric cancer patients treated in the Jimma Medical Center Pediatric Hematology and Oncology Unit (JMC-PHOU) over the period of January 1, 2017, to December 31, 2024.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A retrospective study on growth faltering, incidence of growth faltering and associated factors among childhood cancer patients who were diagnosed cancer positive and treated in JMC-PHOU from January 2017 to December 2024. The weight and height data were transformed into height-for-age z-score (HAZ) and body mass index (BMI)-for-age-z-score (BAZ), respectively, by using WHO AnthroPlus software. Child was defined as in growth faltering state when HAZ and BAZ scores were less than -2 SD. The changes in z-scores were computed using IBM SPSS statistical software, version 25. Descriptive statistics for continuous variables were reported as mean ± SD.For categorical variables they were reported in frequencies/proportions. Logistic regression analysis in IBM SPSS statistical software, version 25 was used to determine the association, reported in odds ratios, of predictor variables with growth status of pediatric cancer patients. Statistical significance was set at 0.05 at 95% confidence interval (95% CI)&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Result&lt;/h3&gt;&lt;div&gt;The prevalence of stunting (height faltering) and thinness (weight faltering) before initiation of cancer treatment were 46.4% and 31.7%, respectively. Over six months after initiation of cancer treatment both height and weight faltering prevalences had increased significantly to 54.9% and 56.5%, respectively. On average, the HAZ and BAZ z-score points declined by about -0.390 [ 95% CI: - 0.440, -0.340; &lt;em&gt;P&lt;/em&gt;&lt; 0.003) and -0.930 [95% CI; -1.050,-0.810; &lt;em&gt;P&lt;/em&gt;&lt; 0.003], respectively over the treatment period. After controlling for other variables in multivariable logistic regression analysis; age at time of diagnosis (AOR=0.983; 95% CI; (0.977, 0.988, &lt;em&gt;P&lt;/em&gt;=0.000), combination therapy (AOR=1.44; 95% CI; 0.432, 4.800; &lt;em&gt;P&lt;/em&gt;=0.015) and the last stage of cancer during treatment initiation (AOR=3.323; 95%CI; 1.308, 8.448; &lt;em&gt;P&lt;/em&gt;=0.012) were found statistically significantly associated with childhood cancer patients stunting. However, regarding thinness only age at time of diagnosis (AOR=1.013; 95%CI; 1.007, 1.018; &lt;em&gt;P&lt;/em&gt;=0.000) was found significantly associated The crude incidence of height faltering was 52.7% while weight faltering was 57.4 % (n=72). The relative incidence of stunting and wasting were 1.06 and 1.17, r","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"67 ","pages":"Article 100681"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Anthropometric and Lifestyle Factors with Cardiovascular Disease Risk: A Case–Control Study in South India Amid Rising CVD Burden","authors":"Prasad Undrajavarapu (Research Scholar) ,&nbsp;Santosh Kumar B (Scientist-E) ,&nbsp;Sai Santhosh Vadakattu (Technical Officer) ,&nbsp;Santhi B (Project coordinator) ,&nbsp;D.Srinivasa Rao (Assistant Professor)","doi":"10.1016/j.nutos.2026.100679","DOIUrl":"10.1016/j.nutos.2026.100679","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular diseases (CVDs) remain the leading cause of mortality globally, with a rapidly increasing burden in low- and middle-income countries, including India. Understanding anthropometric, behavioral, and lifestyle determinants of CVD risk in regional populations is essential for targeted prevention. This study aimed to identify independent predictors of CVD among adults in South India using a multivariable modelling approach.</div></div><div><h3>Methods</h3><div>A clinic-based case–control study was conducted among 100 adults (50 cases, 50 controls) aged 30–80 years. Data on socio-demographic, anthropometric, and lifestyle variables were collected using a structured questionnaire and physical measurements. Bivariate associations were tested using <em>t-tests</em> and <em>χ</em>^<em>2</em> analyses. Variables with <em>p</em>&lt; 0.20 entered a multivariable binary logistic regression model to estimate adjusted odds ratios (AOR) with 95% confidence intervals (CI). Model discrimination was evaluated using the Receiver Operating Characteristic (ROC) curve, and dimensional reduction was explored via Principal Component Analysis (PCA).</div></div><div><h3>Results</h3><div>Mean BMI was significantly higher among CVD cases (27.3 ± 3.4 kg/m²) than controls (23.6 ± 2.9 kg/m²; <em>p</em>&lt; 0.001). Physical inactivity was more prevalent in cases (68%) than controls (36%; <em>p</em> = 0.002), while current alcohol consumption (54% vs. 28%, <em>p</em> = 0.01) and smoking (48% vs. 24%, <em>p</em> = 0.03) were also significantly associated. Multivariable analysis revealed that BMI ≥ 25 kg/m² (AOR = 3.42; 95% CI 1.45–8.09; p = 0.005) and physical inactivity (AOR = 2.97; 95% CI 1.21–7.27; p = 0.018) independently predicted CVD. Vegetarian diet (AOR = 0.49; 95% CI 0.22–0.89; p = 0.041) was protective. The final model demonstrated good fit (Hosmer–Lemeshow p = 0.64) and excellent discrimination (AUC = 0.85; 95% CI 0.78–0.92). PCA explained 72% of total variance, with BMI, age, and inactivity loading most strongly on the first component.</div></div><div><h3>Conclusion</h3><div>Elevated BMI and sedentary lifestyle significantly increased the odds of CVD among South Indian adults, while vegetarian dietary patterns appeared protective. The model’s strong discriminatory power (AUC = 0.85) underscores the potential of combining anthropometric and behavioral indicators for early CVD risk screening. Region-specific prevention strategies emphasizing weight control and physical activity are warranted.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"68 ","pages":"Article 100679"},"PeriodicalIF":0.0,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148141437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean diet components and dry eye disease: Current evidence and mechanistic insights","authors":"Oveis Ahmadzadeh ,&nbsp;Dorsa Ghafouri ,&nbsp;Mahdi Shadnoush ,&nbsp;Pegah Samani ,&nbsp;Abasat Mirzaei ,&nbsp;Zeinab Javid ,&nbsp;Elham Ghorbani ,&nbsp;Mohammad Moradiani Moradabadi ,&nbsp;Ghazal Zolfaghari ,&nbsp;Shamimeh Arabgol ,&nbsp;Ronak Borzooei ,&nbsp;Parichehr Darvish ,&nbsp;Sahar Jafari Karegar","doi":"10.1016/j.nutos.2026.100625","DOIUrl":"10.1016/j.nutos.2026.100625","url":null,"abstract":"<div><h3>Background</h3><div>Dry eye disease (DED) is multifactorial-disorder characterized by tear film instability, ocular surface inflammation, and bothersome symptoms that impair quality of life. Diet-based strategies are increasingly explored as adjuncts to standard care.</div></div><div><h3>Methods</h3><div>We performed a narrative synthesis of clinical and pre-clinical studies evaluating MedDiet components or patterns in relation to DED outcomes.</div></div><div><h3>Results</h3><div>Multiple clinical studies suggest that omega-3 intake can improve tear break-up time (TBUT), Schirmer wetting, and Ocular Surface Disease Index (OSDI) scores in subsets of patients; however, some major trials, particularly those using active placebos such as olive oil, have reported no significant benefit of omega-3 supplementation over control. Components of olive oil or other aspects of the MedDiet can exhibit anti-inflammatory effects, neutralize free radicals, and stabilize the tear film. Antioxidant vitamins, carotenoids, and other components of the MedDiet can help preserve the integrity of the epithelial layer and reduce oxidative stress in tears. Vitamin D can support barrier layer proteins and maintain the balance between T helper 17 cells (Th17) and regulatory T cells (Treg), with rapid associations observed between vitamin D levels and dry eye disease (DED) symptoms, as well as some early outcome studies. Evidence for the MedDiet as a whole is weak, while stronger evidence exists for its individual components, although this varies by concentration, duration of administration, patient population, and control group.</div></div><div><h3>Conclusion</h3><div>Components of the MedDiet show promise in managing DED, particularly in specific DED phenotypes, but further trials with standardized outcomes are needed to confirm these findings.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parenteral nutrition in the ICU","authors":"Annika Reintam Blaser ,&nbsp;Ronan Thibault ,&nbsp;Kaspar F. Bachmann","doi":"10.1016/j.nutos.2026.100635","DOIUrl":"10.1016/j.nutos.2026.100635","url":null,"abstract":"<div><div>This review was undertaken to summarize the current understanding of parenteral nutrition (PN) use in intensive care units (ICUs).</div><div>Based on available literature, roughly 15% of patients receive PN in the ICU. However, PN is not uniformly defined regarding its composition, leading to variable definitions used in clinical practice and studies.</div><div>There seems to be consensus on the absolute contraindications for enteral nutrition, which can then be seen as indications for parenteral nutrition. However, guidelines provide variable recommendations on the dosage and timing for initiating PN with entirely different recommendations regarding supplemental PN.</div><div>PN is associated with complications that must be prevented by following Good Clinical Practices, including considerations of the indications and ongoing monitoring.</div><div>A consensus on the definition of PN should be established to unify future studies. Development of tools for monitoring of metabolic processes and gastrointestinal function is warranted to better design future studies using different routes of nutrition.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100635"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ubiquinol on metabolic profile in prediabetic patients: A randomized, double-blinded, placebo-controlled pilot study","authors":"Pasita Palakornkitti ,&nbsp;Romun Leaovitavat ,&nbsp;Paphitchaya Thetsana ,&nbsp;Patana Teng-umnuay","doi":"10.1016/j.nutos.2026.100627","DOIUrl":"10.1016/j.nutos.2026.100627","url":null,"abstract":"<div><h3>Background/objectives</h3><div>Prediabetes not only increase the risk of developing diabetes, but it is also associated with the development of cardiovascular disease, chronic kidney disease, neuropathy, and retinopathy. Oxidative stress is a well-known contributor to its pathogenesis. This study aimed to examine the potential benefit effect of ubiquinol supplementation, a lipophilic antioxidant, on metabolic profile in prediabetic patients.</div></div><div><h3>Methods</h3><div>This prospective, randomized, double-blind, placebo-controlled pilot study enrolled 20 adults with impaired fasting plasma glucose (FPG), who were randomly assigned to receive ubiquinol (100 mg per day) or placebo. Metabolic profile including FPG, hemoglobin A1C (HbA1C), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) was assessed after 12-week treatment period. Between-group differences were analyzed according to the intention-to-treat principle, with effect sizes calculated to estimate the magnitude of observed effects.</div></div><div><h3>Results</h3><div>HOMA-IR was significantly lower in ubiquinol group compared to placebo group at week 12 (<em>P</em> = 0.028), with a moderate effect size (r =0.490). Median (range) HOMA-IR reduced from 2.23 (0.97) to 1.66 (0.39) for ubiquinol group while increased from 2.20 (0.90) to 2.35 (1.90) for placebo group. No significant difference in other outcome was reported. However, moderate-to-large effect sizes were observed for FPG, HbA1C, and fasting insulin.</div></div><div><h3>Conclusions</h3><div>Daily supplementation of 100-mg ubiquinol for 12 weeks improves insulin sensitivity for prediabetic patients with a favorable safety profile. The observed effect sizes support further investigation in larger, adequately powered trials to confirm the metabolic effects of ubiquinol.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100627"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146070926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary randomized controlled trial of a ginger-containing, clear, fat-free oral nutritional Supplement for chemotherapy-induced nausea and nutritional outcomes","authors":"Rie Tsutsumi ,&nbsp;Soshi Narasaki ,&nbsp;Yousuke T. Horikawa ,&nbsp;Yuna Izumi-Mishima ,&nbsp;Sonoko Yasui-Yamada ,&nbsp;Kazuhiro Nomura ,&nbsp;Hiroshi Sakaue ,&nbsp;Yasuo M. Tsutsumi","doi":"10.1016/j.nutos.2025.12.011","DOIUrl":"10.1016/j.nutos.2025.12.011","url":null,"abstract":"<div><h3>Purpose</h3><div>Chemotherapy-induced nausea and vomiting (CINV) is a serious side effect, affecting approximately 40% of cancer patients and often hindering their ability to continue treatment. In this study, we evaluated the efficacy of an oral nutrition supplement (ONS) designed to decrease patients experiencing CINV.</div></div><div><h3>Methods</h3><div>A total of 98 patients were assessed for eligibility, and 75 patients were prospectively and randomly assigned to one of three groups: the control group without ONS (Control; n = 25), a fat-free clear ONS including ginger extract group (Ginger ONS; n = 25), or the Conventional ONS group (Conv ONS; n = 25). Data collection included Numerical Rating Scale (NRS) for nausea, number of vomiting episodes, use of antiemetic drugs, blood biochemical tests, serum substance P levels, Quality of Life (QOL) Assessment, and dietary intake.</div></div><div><h3>Results</h3><div>NRS for nausea scores after the second cycle of chemotherapy were 7.8 ± 1.8 in the Control group, 3.5 ± 1.4 in the Ginger ONS group, and 5.7 ± 1.9 in the Conv ONS group. Substance P levels decreased significantly in the Ginger ONS group compared to the Conv ONS and Control groups. In addition, the Ginger ONS group showed a significant improvement in energy and protein intake. Body weight and lean body mass were also improved. Finally, QOL was significantly improved in the Ginger ONS group following the second cycle of chemotherapy (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Taken together, these data suggest that Ginger ONS is associated with improvements in nausea and energy/protein intake following chemotherapy. It is possible that comprehensive differences in nutritional composition—including the ginger extract, the amount and quality of protein, absence of fat, palatability, etc.—may have contributed to the observed outcomes.</div></div><div><h3>Trial Registry</h3><div><span><span>https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000060201</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100617"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146070927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}