Clinical Nutrition Open Science最新文献

{"title":"The role of nutrition in various endocrine and metabolic diseases","authors":"Nanny Natalia Mulyani Soetedjo","doi":"10.1016/j.nutos.2025.05.015","DOIUrl":"10.1016/j.nutos.2025.05.015","url":null,"abstract":"<div><div>The endocrine system plays a central role in maintaining the body's homeostasis. Endocrine and metabolic disorders are complex and critical areas of healthcare, given their crucial role in regulating various body functions. The author presents nutritional therapy recommendations that can play an essential role in the management of endocrine and metabolic disorders, namely panhypopituitarism, adrenal fatigue, osteoporosis, obesity, dyslipidemia, hyperuricemia, aging, menopause and andropause, thyroid disorders, and diabetes, to provide a holistic understanding of the role of nutrition and improve the quality of life of patients with these conditions.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 164-188"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health assessment of 4–13 years students living in a rural Andean region: The EVANES study design protocol","authors":"Fátima Morales ,&nbsp;Marcela Guerendiain","doi":"10.1016/j.nutos.2025.06.003","DOIUrl":"10.1016/j.nutos.2025.06.003","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>In Ecuador, stunting and overweight are the main nutritional problems identified at school age in the indigenous population, associated with infectious diseases and diarrhoea. The Andean region has the largest indigenous population in the country, which suffers from inequality and poverty, especially those inhabiting rural areas. Clinical studies have shown a high infection vulnerability of rural populations. Therefore, we aim to evaluate nutritional status according to dietary intake, intestinal parasitic infections, household and environmental conditions, ant their relation with cognitive development of schoolchildren in rural highlands of Ecuador in order to develop prevention and health promotion programmes adapted to the needs of these children and their families.</div></div><div><h3>Methods</h3><div>The EVANES study is a multi- and interdisciplinary approach designed to evaluate the dietary intake, anthropometric parameters, intestinal parasitic infections, hygienic-sanitary and environmental conditions and cognitive development of Ecuadorian schoolchildren.</div></div><div><h3>Results</h3><div>This exhaustive assessment may be useful for: identifying nutritional issues, establishing health programmes for disease prevention and health promotion, clarifying the aetiology of stunting in the indigenous population, and defining reference patterns for the diagnosis of anaemia in the highlands in childhood.</div></div><div><h3>Conclusions</h3><div>The EVANES study could be a model protocol for other areas of Ecuador and countries, and can contribute to improving the health and development of children in Latin American and highland countries. It is expected to contribute to the scientific community with unique insights into the health status of rural indigenous schoolchildren living at high altitude, in order to develop appropriate health programmes and policies for disease prevention and health promotion in these populations.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 189-207"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional management of survivors of critical illness: The clinical pharmacists' role","authors":"Zenzi Rosseel ,&nbsp;Stephanie C.M. Wuyts ,&nbsp;Marjoleine Desmedt ,&nbsp;Sandrina von Winckelmann ,&nbsp;Elisabeth De Waele ,&nbsp;Claudine Ligneel ,&nbsp;Pieter-Jan Cortoos","doi":"10.1016/j.nutos.2025.06.002","DOIUrl":"10.1016/j.nutos.2025.06.002","url":null,"abstract":"<div><div>Critically ill patients face many challenges such as dysphagia leading to muscle loss and malnutrition. To prevent and treat malnutrition, ICU protocols from the European Society of Clinical Nutrition and Metabolism (ESPEN) and American Society of Parenteral and Enteral Nutrition (ASPEN) are established, available and implemented in ICU's, However, in the post-ICU phase, little literature is available evaluating the nutritional needs of those patients as well as the challenges they are facing. Artificial nutrition can be used to provide adequate nutrition, but in combination with various drugs such as prokinetics or analgesics drug side effects, drug-drug and drug-nutrition interactions may occur resulting in suboptimal nutritional therapy. To prevent these problems, clinical pharmacists can provide meaningful support. Clinical pharmacists are specialists in medication review and medication reconciliation guaranteeing adequate dosing, preventing side effects and checking for drug appropriateness. Through multidisciplinary collaboration, they are also often involved in nutritional support. The aim of this article was to review current literature regarding the roles of clinical pharmacists as well as providing insights in their future role in post-ICU nutritional care.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 127-138"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of lead acetate-induced testicular dysfunction in male wistar rats: A possible role for combined extracts of Syzygium aromaticum and Xylopia aethiopica seeds","authors":"Emmanuel Nnaemeka Uhuo,&nbsp;Paulinus Chinedu Nwuke,&nbsp;Chiemeziem Adnma Obike,&nbsp;Prince Ogochukwu Alaebo,&nbsp;Becky Chinyere Odili","doi":"10.1016/j.nutos.2025.06.006","DOIUrl":"10.1016/j.nutos.2025.06.006","url":null,"abstract":"<div><h3>Background</h3><div>Lead acetate poisoning induces testicular dysfunction through the enhancement of oxidative stress and morphological abnormalities in the testes. Phytoconstituents exhibit antioxidative effects that enhance sperm parameters. This study sought to evaluate the efficacy of a combination extract of <em>Syzygium aromaticum</em> and <em>Xylopia aethiopica</em> seeds (1:1 ratio) in mitigating lead-induced testicular dysfunction in Wistar rats.</div></div><div><h3>Methods</h3><div>Twenty male Wistar rats were divided into four groups (n=5): (i) Normal Control (NC), (ii) Lead Acetate Control (PbC), (iii) Lead Acetate + 200 mg/Kg (Pb-200), and (iv) Lead Acetate + 400 mg/Kg (Pb-400). Groups ii-iv received 60 mg/kg of lead acetate orally, followed by the administration of the extract after a 30-minute interval per day for 28 days. Subsequently, relative weight, testicular weight, sperm parameters, reproductive hormones, malondialdehyde, antioxidant enzymes, and lipid profile were assessed.</div></div><div><h3>Results</h3><div>Testicular and associated weight exhibited a substantial reduction (<em>P</em>&lt;0.05) in NC compared to PbC. A comparable trend was observed in Pb-200 and Pb-400 relative to NC. The percentage of aberrant morphology considerably rose (<em>P</em>&lt;0.05) in PbC and decreased in Pb-200 and Pb-400. A reduction in pH was observed in PbC compared to NC and the treatment groups. Sperm count, motility, and viability were decreased (<em>P</em>&lt;0.05) in PbC compared to Pb-200 and Pb-400.Likewise, serum testosterone, follicle-stimulating hormone, luteinizing hormone, and glutathione exhibited a similar pattern. A notable reduction (<em>P</em>&lt;0.05) in malondialdehyde, triacylglycerol, cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels was seen in PbC compared to the treatment groups and NC. A reduction in these parameters was recorded in Pb-400 compared to Pb-200. Moreover, the activities of superoxide dismutase, catalase, and glutathione peroxidase exhibited a substantial reduction (<em>P</em>&lt;0.05) in PbC compared to Pb-200, Pb-400, and NC. The activity of these enzymes was elevated in Pb-400 relative to Pb-200.</div></div><div><h3>Conclusion</h3><div>The combined extracts of S. <em>aromaticum</em> and <em>X. aethiopica</em> seeds mitigate lead acetate-induced testicular damage in Wistar rats through their antioxidant capabilities.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 246-264"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary fat intake and benign breast diseases: a systematic review","authors":"Amir Hossein Faghfouri ,&nbsp;Fatemeh Azizi-Soleiman ,&nbsp;Sevda Saleh-Ghadimi ,&nbsp;Hamed Jafari-Vayghan","doi":"10.1016/j.nutos.2025.05.014","DOIUrl":"10.1016/j.nutos.2025.05.014","url":null,"abstract":"<div><div>Benign breast diseases (BBDs) may herald breast cancer, and diet is one of the most important environmental factors associated with both conditions. Dietary fat intake has been suggested as a potential risk factor for BBDs. We performed a systematic review to comprehensively scrutinize the current knowledge regarding the relationship between dietary fat intake (DFI), the types of consumed fats, and BBDs. A deep and meticulous search was conducted to gather relevant publications until 30th December 2023. The search was conducted in the following databases: PubMed/Medline, Web of Science, Embase, and Scopus. Eligible studies included female participants with BBDs, employed cross-sectional, case-control, or cohort designs, assessed dietary fat intake using validated tools, and reported outcomes as odds ratios, relative risk, or hazard ratios. After screening, a total of nine studies were included in our final review. The data required were extracted, and the risk of bias was assessed. Our systematic review found that the consumption of vegetable fat could be protective against BBDs while the consumption of animal fat and monounsaturated fat was associated with a higher risk of BBDs. No significant relationship was found between the intake of saturated and polyunsaturated fats and BBDs. A robust relationship between the consumption of various types of dietary fats and BBDs could not be elucidated based on available evidence. Nevertheless, it is advisable for patients who are at risk of BBDs to follow healthy eating habits and be vigilant about the excessive consumption of fats and oils.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 102-113"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional interventions and barriers for patients early after burn injury: A retrospective evaluation of medical records","authors":"Josefin Dimander ,&nbsp;Agneta Andersson ,&nbsp;Fredrik Huss ,&nbsp;Catarina Lindqvist","doi":"10.1016/j.nutos.2025.06.007","DOIUrl":"10.1016/j.nutos.2025.06.007","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Inadequate intake and barriers to nutritional therapy are challenges in burn care. Post-burn injury nutritional care practices are rarely reported, particularly after minor injuries. The aim of this study was to describe nutritional interventions, identify barriers to nutritional intervention, and compare the documentation of nutrition for patients after minor and major burn injuries.</div></div><div><h3>Methods</h3><div>A retrospective single-centre medical record review was conducted on patients aged 18 and older who were admitted for more than 72 h between 2017 and 2019 at one of Sweden's two national burn centres. A content analysis and descriptive statistics were used to analyse the data, and differences were explored between patients with minor and major burn injuries.</div></div><div><h3>Results</h3><div>A total of 134 patients were included in the study: 90 patients had minor burn injuries (mean total burn surface area (TBSA) 8.1 % ± 5.0), and 44 patients had major burn injuries (mean TBSA 37.8 % ± 17.2). Nutritional supplement therapy (93 %) and nutrition prescription (91 %) were the most common interventions. Interventions targeting meals and snacks (43 %) and meal support (40 %), were documented less frequently. Fasting (93 %) and gastrointestinal symptoms (49 %) were the most common barriers.</div><div>Significantly more interventions (including enteral/parenteral nutrition, and vitamin/mineral supplementation) and barriers (primarily related to enteral nutrition and fasting) were documented for patients with major burn injuries.</div></div><div><h3>Conclusion</h3><div>This study concludes that while most patients have oral intake, vitamin and mineral supplementation and medical nutritional therapy were more frequently documented than meal/snack interventions and meal support. The lack of dietary interventions, whether unperformed or undocumented, needs further investigation. Frequent documentation of barriers to nutritional interventions suggests that patients post-burn injury are at risk of inadequate energy and protein intake. Therefore, emphasising nutritional therapy and its documentation in post-burn care is crucial, regardless of burn severity.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 218-232"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of ultra-processed foods on the gut microbiome and gastrointestinal complaints after bariatric surgery: A narrative review","authors":"Hendrika J.M. Smelt ,&nbsp;Sjaak Pouwels ,&nbsp;Christine Stier ,&nbsp;Johannes F. Smulders","doi":"10.1016/j.nutos.2025.06.005","DOIUrl":"10.1016/j.nutos.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div>Bariatric surgery (BS) leads to malabsorption trough alterations of the gastrointestinal tract, which can result in changes in the gut microbiome (GM). Disturbances in the GM are associated with disruptions in nutrient digestion and absorption, regulation of intestinal motility, and maintenance of intestinal epithelium integrity. GM diversity significantly changes after BS but is not fully restored.</div></div><div><h3>Goal of this review</h3><div>A significant number of patients also experience chronic, unexplained abdominal complaints. It is presumed that food intake may play a more substantial role than previously thought. This review provides an overview of the (nutritional) factors that may contribute to abdominal pain after bariatric surgery.</div></div><div><h3>Conclusion</h3><div>Worldwide, many ultra-processed foods are consumed, which disrupt the GM and likely contribute to gastrointestinal symptoms and exacerbate the chronic inflammatory process. However, the influence of these products on the development of gastrointestinal complaints after BS has not yet been studied. This should be the focus for future research.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 208-217"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of protein intake distribution across meals in maintenance of physical performance and muscle strength in older adults: An exploratory study based on secondary data analysis of the PRevention Of Malnutrition In Senior Subjects in the EU (PROMISS) trial","authors":"Hanneke A.H. Wijnhoven ,&nbsp;Riikka T. Niskanen ,&nbsp;Ilse Reinders ,&nbsp;Merja H. Suominen ,&nbsp;Satu K. Jyväkorpi ,&nbsp;Ingeborg A. Brouwer ,&nbsp;Margreet R. Olthof ,&nbsp;Marjolein Visser","doi":"10.1016/j.nutos.2025.05.008","DOIUrl":"10.1016/j.nutos.2025.05.008","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>There is increasing interest in the impact of protein intake distribution across meals on muscle health and physical performance in older adults, but previous studies have yielded conflicting results. This study aimed to explore the role of protein intake distribution across meals in maintenance of physical performance and muscle strength in older adults with an habitual low protein intake before and during a protein intervention trial.</div></div><div><h3>Methods</h3><div>Secondary data analysis was performed using data of the 6-month PRevention Of Malnutrition In Senior Subjects in the EU (PROMISS) trial, which focussed on increasing protein intake among community older adults (n=276) with habitual low (&lt;1.0 g/adjusted body weight/d) protein intake. Dietary intake was assessed by 3-day food diaries combined with three 24-hour dietary recalls. We examined the association between protein intake distribution and 400-m walk time and leg extension strength, including cross-sectional associations at baseline and longitudinal associations over six months. The three parameters examined included the number of meals high (≥35 g) in protein, protein distribution across meals assessed by the coefficient of variation, and the percentage of protein intake from breakfast. Additionally, we examined whether these longitudinal associations were modified by the intervention to increase protein intake.</div></div><div><h3>Results</h3><div>None of the protein intake distribution parameters were associated with 400-m walk time or leg extension strength, neither cross-sectionally nor longitudinally, except for the cross-sectional association between a higher percentage of protein intake from breakfast and slower walking pace in women only (b = 1.8 (95% CI 0.1–3.6)). Longitudinal associations were not modified by the protein intervention.</div></div><div><h3>Conclusion</h3><div>Distribution of protein intake across meals does not seem to play an important role in maintaining physical performance or muscle strength in older adults with an habitual low protein intake, even if protein intake is increased.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 89-101"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of sports and nutrition interventions on the bodyfat and BMI of primary school children (compared to the effects of a lockdown period while Covid19-pandemic)","authors":"Paula Moliterno ,&nbsp;Magdalena Heindl ,&nbsp;Hanna Rosenauer ,&nbsp;Emma Malina-Altzinger ,&nbsp;Tamara Konrad ,&nbsp;Kurt Widhalm","doi":"10.1016/j.nutos.2025.05.013","DOIUrl":"10.1016/j.nutos.2025.05.013","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>The increasing rates of overweight and obesity highlight the need for prevention. The EDDY prevention study aimed to assess whether a school-based program with sports and nutrition interventions could improve the lifestyle of elementary school children in Vienna, Austria.</div></div><div><h3>Methods</h3><div>During the school year 2018/19, 146 children (8–11 years) were assigned to an intervention group (I1, n=73) or control group (C1). In 2019/20, 130 children were included as a second control group (C2) during the COVID-19 pandemic. Only the intervention group received weekly nutrition and physical activity lessons for 5 months. Weight, height, and body fat were examined at baseline and the end of the project. Body fat was determined by bioelectric impedance analysis using a multi-frequency segmental body composition analyzer. Changes in body fat percentage and BMI after the intervention were compared between groups using Wilcoxon or Student T-Test. Additionally, comparisons were performed with the control group exposed to the first COVID-19 lockdown, where no intervention occurred.</div></div><div><h3>Results</h3><div>The baseline median BMI for the I1 was 20.3 (14.9–30.6) kg/m², while the C1 was 18.5 (14.0–26.3) kg/m². After the intervention, a significant modest reduction in body fat percentage (<em>P</em> &lt; 0.01) was achieved [−1.35 (−4.20–0.90) %], compared to C1 [0.10 (−2.90–3.00) %] and C2 [1.88 (−2.55–7.51) %]. Significant differences in BMI changes were observed only between the I1 [0.44 (−1.29–1.84) kg/m²] and the C2 [1.31 (−0.49–3.27) kg/m²] (<em>P</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>A 5-month health intervention promoting nutritional education and additional physical activity in schoolchildren from Vienna positively affected body fat percentage, highlighting the importance of adjusting the school system. The additional challenges of the COVID-19 lockdown were evident in fat mass and BMI, illustrating the dramatic consequences of a lack of daily structure and the important influence of the family environment. Differences in BMI and body fat development suggest the importance of assessing body composition to monitor children's nutritional status.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 67-78"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and coexistence of malnutrition, sarcopenia, frailty and sarcopenic obesity among older adults in the community: Results from a prospective cohort study","authors":"Zhishan Jiang,&nbsp;Adrian Slee,&nbsp;Christine Elizabeth Weekes","doi":"10.1016/j.nutos.2025.05.003","DOIUrl":"10.1016/j.nutos.2025.05.003","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background &amp; aims&lt;/h3&gt;&lt;div&gt;Advanced age is an independent risk factor for malnutrition, sarcopenia, frailty and sarcopenic obesity (MSFSO), and each condition is associated with adverse outcomes, such as higher risk of morbidity and mortality, higher incidence of hospitalization, increased risk of falls and disability, poorer quality of life (QOL), and greater use of health and social care resources. Some characteristics overlap between MSFSO, yet there is a lack of research into the coexistence of these conditions currently. Therefore, this study aimed to explore the prevalence and coexistence of MSFSO among older adults in different community settings, to identify potential associated factors, and to examine its associations with mortality, QOL and contacts with health and social care professionals (HSCPs).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Data were retrieved from a prospective cohort study, recruiting older adults (≥60 years of age) from community settings. Baseline characteristics from two settings, general practice (GP) and intermediate care (IC), were analyzed in this study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;347 participants were analyzed (57% females, mean age 77 ± 9 years, mean body mass index 25.8 ± 5.7 kg/m&lt;sup&gt;2&lt;/sup&gt;), with 52% from GP and 48% from IC. The prevalence rates were 21.6% for malnutrition, 50.1% for sarcopenia, 49.3% for frailty, and 12.1% for sarcopenic obesity. More than half of the subjects (53.8%) experienced at least one of the above conditions, with 4 participants (1.3%) suffering from all four conditions simultaneously. The IC cohort was older and had a poorer health status compared to the GP population, resulting in a significantly higher prevalence of malnutrition (41.5% vs. 7.9%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), sarcopenia (85.7% vs. 16.8%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), frailty (91.1% vs. 10.0%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), sarcopenic obesity (17.9% vs. 7.3%, &lt;em&gt;P&lt;/em&gt; = 0.006) and coexisting MSFSO (83.7% vs. 12.4%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001). In addition, strong associations were observed between higher coexistence of MSFSO conditions and participants from the IC setting (IRR 4.12, 95%CI 3.06–5.56, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) or with more comorbidities (IRR 1.55, 95%CI 1.13–2.12, &lt;em&gt;P&lt;/em&gt; = 0.007). The majority of participants (90.3%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) who subsequently died during the study had at least two conditions of MSFSO. Subjects with coexistence of MSFSO also had poorer perceived QOL (EQ-5D Visual Analogue Scale: none vs. ≥2 conditions = 85 scores vs. 56 scores, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) and generally more contacts with HSCPs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Coexistence of MSFSO was associated with a greater risk of mortality, a poorer perceived QOL and an increased contact with health and social care services. Furthermore, people in the IC setting or with more comorbidities were more likely to experience a higher coexistence of MSFSO. The differences in characteristics and MSFSO prevalence rates bet","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 26-41"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}