Clinical Nutrition Open Science最新文献

{"title":"Nutritional assessment in patients with chronic liver disease – Current accessibility and implementation","authors":"Daphne Bot ,&nbsp;Maarten E. Tushuizen ,&nbsp;Bart van Hoek","doi":"10.1016/j.nutos.2024.10.008","DOIUrl":"10.1016/j.nutos.2024.10.008","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Poor body composition is associated with impaired outcomes in patients with chronic liver disease (CLD), and various assessment tools are used. The aim of this study is to gain insight into the clinical practice of nutritional assessment in patients with CLD.</div></div><div><h3>Methods</h3><div>A semi-structured online survey on nutritional assessment tools for measuring body composition in patients with CLD was conducted among hepatologists and dietitians, mainly from hospitals between April 2023 and May 2023.</div></div><div><h3>Results</h3><div>A total of 45 eligible surveys were included in this study (dieticians N=35, hepatologists N=10). All dieticians had at least one nutritional assessment tool available. Bio-electrical impedance and hand-grip strength were the most available and used. The most important reasons for assessment were diagnosis of nutritional status, evaluation of nutritional intervention and for assessing risk of mortality. A proportion of 49% of the dieticians and 60% of the hepatologists respectively were familiar with the ‘European society of parenteral and enteral nutrition Guideline Clinical Nutrition in Liver disease’. Only 13% of dieticians and 60% of the hepatologists knew the ‘European Association for the Study of the Liver Clinical Practice Guidelines on nutrition in chronic liver disease’ and only eight dieticians and one hepatologist used a protocol for nutritional assessment in patients with CLD.</div></div><div><h3>Conclusion</h3><div>The importance of measuring body composition in patients with CLD for diagnosing and monitoring nutritional status and for assessing risk of mortality is well-known by dieticians and most hepatologists. However, implementation of the current guidelines is substandard and should be improved.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 206-214"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 infection induces human milk antibodies capable of mediating multiple functional activities","authors":"Jared Sheehan ,&nbsp;Aline Andres ,&nbsp;Laxmi Yeruva ,&nbsp;Alistair J. Ramsay","doi":"10.1016/j.nutos.2024.10.009","DOIUrl":"10.1016/j.nutos.2024.10.009","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Passive transfer of antibodies through breastfeeding is a potential mode of protection for newborns and infants following maternal SARS-CoV-2 infection. The primary goal of this study was to evaluate and characterize SARS-CoV-2 Spike (S)-specific antibodies in human milk samples collected longitudinally from a cohort of convalescent mothers.</div></div><div><h3>Methods</h3><div>SARS-CoV-2 infected participants enrolled in this study were lactating women aged 29–36 years with a confirmed COVID-19 diagnosis who donated milk samples at intervals over the six-month study period. Samples were evaluated for antibody subclass SARS-Cov-2 S glycoprotein binding activity by ELISA, and for the capacity of antibodies purified from these samples to mediate neutralizing antibody (nAb) activity in S pseudovirus inhibition assays and phagocytic activity in an antibody-dependent phagocytosis assay.</div></div><div><h3>Results</h3><div>Robust S-reactive IgM, IgG and IgA ELISA titers were found at day 7 after enrollment, with IgG and IgA levels persisting through 6 months. The majority of S-reactive IgA in milk was secretory in nature. Strong IgG (mean IC₅₀ value 29.19μg/ml) and IgA (mean IC₅₀ value 10.17μg/ml) nAb activity was found in all convalescent samples at 14 days with a decline by 3 months after the onset of symptoms but was not seen in pre-pandemic controls. Both IgG and IgA antibodies mediated phagocytic activity in samples from all subjects by day 14 after the onset of symptoms.</div></div><div><h3>Conclusions</h3><div>Our findings indicate that human milk from SARS-CoV-2 infected mothers have the capacity to transfer SARS-CoV-2-specific antibodies capable of mediating multiple functional activities to newborns via breastfeeding.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 215-226"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamin D levels in older adults with and without dyslipidemia: A comparison using baseline data from the Birjand Longitudinal Aging Study (BLAS)","authors":"Fatemeh Alizadeh ,&nbsp;Fatemeh Salmani ,&nbsp;Farshad Sharifi ,&nbsp;Mitra Moodi ,&nbsp;Masomeh Khorashadizadeh ,&nbsp;Zoya Tahergorabi","doi":"10.1016/j.nutos.2024.10.004","DOIUrl":"10.1016/j.nutos.2024.10.004","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Nowadays, research on extraskeletal effects of Vitamin D on human health is growing This study aimed to Serum vitamin D levels measurement in older adults with and without dyslipidemia: a comparison using baseline data from the Birjand Longitudinal Aging Study (BLAS).</div></div><div><h3>Methods</h3><div>This cross-sectional study included 420 elderly people over 60 years old divided into in two equal groups with and without dyslipidemia. Data were drawn from the first phase of Birjand Longitudinal Aging Study (BLAS). A questionnaire containing demographic information and Mini nutritional assessment (MNA) was completed through interviews. Body mass index (BMI) was calculated, and after 12 hours of fasting, 5 mL of venous blood was taken to measure the serum levels of 25(OH) D and lipid profile.</div></div><div><h3>Results</h3><div>Among the elderly, 37.3%, 33.3% and 29.3% had sufficient, insufficient and deficient Vitamin D levels, respectively. A significant difference in triglyceride levels was observed between the two groups of elderly individuals with insufficient and deficient Vitamin D levels (<em>P</em>=0.011). Multiple logistic regression showed that an increase in the atherogenic index of plasma (AIP) (<em>P</em> = 0.005, OR = 18.46) and BMI (<em>P</em> = 0.001, OR = 18.46) significantly increased the odds of dyslipidemia.</div></div><div><h3>Conclusions</h3><div>Vitamin D deficiency or insufficient was common among the elderly and was associated with elevated serum triglyceride levels.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 155-162"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of resting energy expenditure predictive equations in coronavirus disease 2019 (COVID-19) survivors","authors":"Montserrat Montes-Ibarra ,&nbsp;Camila L.P. Oliveira ,&nbsp;Taiwo Olobatuyi ,&nbsp;Maria Cristina Gonzalez ,&nbsp;Richard Thompson ,&nbsp;D. Ian Paterson ,&nbsp;Carla M. Prado","doi":"10.1016/j.nutos.2024.10.007","DOIUrl":"10.1016/j.nutos.2024.10.007","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Coronavirus disease 2019 (COVID-19) may be associated with abnormal energy metabolism and lead to inaccurate resting energy expenditure (REE) estimations by predictive equations. Here, we report measured REE (mREE) of a group of COVID-19 survivors and compared its accuracy against predicted REE (pREE).</div></div><div><h3>Methods</h3><div>This was a cross-sectional analysis of patients who survived COVID-19 prior to July 2021. An indirect calorimeter was used for mREE and compared against 21 pREE equations, 10 of which used a measure of body composition. Paired t-tests and Bland-Altman analysis were used to evaluate agreement and relative accuracy or bias for percentage error between pREE and mREE; measurements within ±10% were considered accurate.</div></div><div><h3>Results</h3><div>We assessed 38 COVID-19 survivors; age: 48.5y (interquartile range: 40.2, 60.0), body mass index: 29.3±5.6 kg/m², mREE: 1520± 275 kcal/d, time since COVID-19: 183.2 ±34.4 days. Ten (47.6%) pREE equations were significantly different from mREE (<em>P</em> &lt;0.05). Harris-Benedict equation had the smallest limits of agreement, ranging from -14.3% to 25.8% (or -249 to 393 kcal/d). Mifflin St-Jeor was the most accurate equation (within 10% of mREE). The best performing equation (Mifflin St-Jeor) still over or under-estimated pREE in ∼37% of the patients.</div></div><div><h3>Conclusion</h3><div>A large variability in mREE versus pREE was observed in COVID-19 survivors. Even the most accurate equation (Mifflin St-Jeor) exhibited higher inaccuracies compared to mREE. We need to explore better methods to estimate energy requirements during the COVID-19 recovery period, until more accurate predictive equations are developed this population.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 175-182"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediabetes detection in unconstrained conditions using wearable sensors","authors":"Dimitra Tatli ,&nbsp;Vasileios Papapanagiotou ,&nbsp;Aris Liakos ,&nbsp;Apostolos Tsapas ,&nbsp;Anastasios Delopoulos","doi":"10.1016/j.nutos.2024.09.013","DOIUrl":"10.1016/j.nutos.2024.09.013","url":null,"abstract":"<div><div>Prediabetes is a common health condition that often goes undetected until it progresses to type 2 diabetes. Early identification of prediabetes is essential for timely intervention and prevention of complications. This research explores the feasibility of using wearable continuous glucose monitoring along with smartwatches with embedded inertial sensors to collect glucose measurements and acceleration signals respectively, for the early detection of prediabetes. We propose a methodology based on signal processing and machine learning techniques. Two feature sets are extracted from the collected signals, based both on a dynamic modeling of the human glucose-homeostasis system and on the Glucose curve, inspired by three major glucose related blood tests. Features are aggregated per individual using bootstrap. Support Vector Machines are used to classify normoglycemic vs. prediabetic individuals. We collected data from 22 participants for evaluation. The results are highly encouraging, demonstrating high sensitivity and precision. This work is a proof of concept, highlighting the potential of wearable devices in prediabetes assessment. Future directions involve expanding the study to a larger, more diverse population and exploring the integration of CGM and smartwatch functionalities into a unified device. Automated eating detecting algorithms can also be used.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 163-174"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intervention of roasted cashew nut supplement against endothelial renal vasoconstriction disease in hypertensive rats exposed to mixed-fractionated petroleum products","authors":"J.K. Akintunde ,&nbsp;A.O. Okunubi ,&nbsp;O.A. Dosumu ,&nbsp;A.T. Omidiran ,&nbsp;A.D. Folayan ,&nbsp;S.O. Salami","doi":"10.1016/j.nutos.2024.10.005","DOIUrl":"10.1016/j.nutos.2024.10.005","url":null,"abstract":"<div><div>There have been increasing concerns about the great risks posed by petroleum products which contribute to the progression endothelial renal vasoconstriction and hypertension. This study aims to investigate the modulatory effects of Roasted cashew nut on rats induced with endothelial renal vasoconstriction syndrome upon exposure to mixed fractionated petroleum products (MFPP). Seventy male albino rats were randomized into seven (n=10) groups. Group I (normal control) was given distilled water. Group II was administered with MFPP (20 %/day). Group III was administered with MFPP (20 %/day) + atenolol (50 mg/kg). Group IV was administered with MFPP (20 %/day) + 10 % roasted cashew nut (10 %RCN). Group V was administered with MFPP (20 %/day) + (20 %RCN). Group VI was treated with 10 %RCN while Group VII was treated with 20 %RCN. Data were analyzed using one-way analysis of variance (ANOVA) and Duncan's multiple range test with <em>P</em>&lt;0.05 considered significant. Oral RCN intervention prohibited endothelial renal vasoconstriction syndrome and hypertension by down-regulating the pro-inflammatory cytokines including IL-10, TNF-α, HIF-1, MCP-1 and p53 with a concomitant inhibition of the activities of arginase, phosphodiesterase-5¹ (PDE-5¹) and angiotensin converting enzyme (ACE). Furthermore, endothelial renal vasoconstriction syndrome was pointedly abrogated by treatment with RCN as depicted by the reduced activities of the enzymes of ATP hydrolysis (ATPase, ADPase, AMPase and ADA), AChE and MAO-A with a subsequent upsurge in the level of NO while the histological derangements caused by MFPP were completely abated. This study thus authenticates the proposition that RCN may be a valuable therapy in ameliorating apoptosis, renal pro-inflammatory cytokines and enzymes of ATP-hydrolysis in endothelial renal vasoconstriction syndrome and hypertensive rat model on exposure to MFPP.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 183-205"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between early postoperative food intake and postoperative hospital length of stay in patients undergoing cardiac surgery: A retrospective observational single-center study","authors":"Eri Natsuhori ,&nbsp;Takeshi Unoki","doi":"10.1016/j.nutos.2024.10.003","DOIUrl":"10.1016/j.nutos.2024.10.003","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Perioperative nutritional status is critical during the postoperative recovery process in patients undergoing cardiac surgery. Several studies on patients undergoing cardiac surgery have reported low energy intake in early postoperative food intake via oral nutrition; however, no study has shown an association of low energy intake with postoperative hospital length of stay (LOS). This study aimed to determine whether early postoperative low food intake was associated with prolonged postoperative hospital LOS in patients undergoing cardiac surgery.</div></div><div><h3>Methods</h3><div>This was a retrospective, observational, singlecenter study conducted in patients aged ≥18 years undergoing elective cardiac surgery from January 1, 2020, to May 31, 2023. Patients were categorized by food intake as food intake &lt; 50% (low food intake group) and ≥ 50% (adequate food intake group) at lunch on postoperative day (POD) 3. The primary outcome of this study was the postoperative hospital LOS. A generalized linear model was used to examine the association between food intake and postoperative hospital LOS using the following explanatory variables: age, European System for Cardiac Operative Risk Evaluation (EuroSCORE) II value, preoperative risk of malnutrition, activities of daily living status, Sequential Organ Failure Assessment score, and C-reactive protein level.</div></div><div><h3>Results</h3><div>Of the 315 patients, 104 (33.0%) had a food intake of &lt;50% on POD3. There were no significant differences in age, sex, EuroSCORE II value, and comorbidities between the two groups. Patients in the low-food intake group had a significantly lower Barthel Index (6.7% vs. 1.4%, p = 0.017) and a higher malnutrition risk according to the Mini Nutritional Assessment Short Form score (40.4% vs. 28.2%, p = 0.043). Food intake of &lt;50% on POD3 was associated with prolonged postoperative hospital LOS (β = 1.135 [95% confidence interval: 1.004–1.262], p = 0.018).</div></div><div><h3>Conclusions</h3><div>Low food intake on POD3 is associated with prolonged postoperative hospital LOS in patients undergoing elective cardiac surgery. Early postoperative food intake should be closely monitored in patients after elective cardiac surgery.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 146-154"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer predictive model derived from bioimpedance measurements using machine learning methods","authors":"José Luis García Bello ,&nbsp;Taira Batista Luna ,&nbsp;Agustín Garzón Carbonell ,&nbsp;Ana de la Caridad Román Montoya ,&nbsp;Alcibíades Lara Lafargue ,&nbsp;Héctor Manuel Camué Ciria ,&nbsp;Yohandys A. Zulueta","doi":"10.1016/j.nutos.2024.10.006","DOIUrl":"10.1016/j.nutos.2024.10.006","url":null,"abstract":"<div><h3>Objective</h3><div>This work is aimed to develop a machine learning predictions of health status derived from bioimpedance measurements of adult healthy and cancer individuals.</div></div><div><h3>Methods</h3><div>We conducted a pilot random study containing 2881 female (1220) and male (1661) patients ranging in age between 19 to 96 years old are studied. Among of them, 33 are diagnosed with cancer disease, the rest are healthy. After balancing the initial data, the data of interest contains 1.460 individuals ranging in age between 19 and 93 years old (734 female and 726 male), with 704 diagnosed with cancer and 756 healthy, respectively. The bioimpedance parameters are obtained by measuring standard tetrapolar whole-body configuration. The bioimpedance analyser (BioScan98®) is used, collecting fundamental bioelectrical and other parameters of interest. A classification model are performed, followed by a prediction of phase angle and body mass index.</div></div><div><h3>Results</h3><div>The classification model reveal two robust parameters for predicting the health status, namely the impedance, the total body water and the phase angle with a 97%, 34% and 30 % of significance (respectively), with an area under the receiver operating characteristic curve of AUC = 1.00. The phase angle predictions agrees with previous reports of other type of pathologies, where higher phase angle values is ascribed to better health status and male have larger values than female. Recommendations regarding the capacitive reactance as a robust parameter to inferring health status is discussed. The cubic support vector machine model shows great accuracy predicting the nutritional status based on body mass index of both healthy and cancer patients.</div></div><div><h3>Conclusion</h3><div>The classification, phase angle and body mass index predictive models developed in this work are of the great importance to assist the diagnosis, differentiating between healthy and cancer individual with great accuracy. Despite the moderate lack of body mass index association with cancer, this model can be used for prompt diagnosis.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 131-145"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longer sitting times and bulk amounts of rice intake are associated with the increased risks of metabolic dysfunction-associated fatty liver diseases (MAFLD): A case-control study","authors":"Shahinul Alam ,&nbsp;Mahbuba Kawser ,&nbsp;Saif Uddin Nisar Ahmed ,&nbsp;Md Mahabubul Alam ,&nbsp;Md Saiful Islam ,&nbsp;Shayla Nasrin","doi":"10.1016/j.nutos.2024.10.002","DOIUrl":"10.1016/j.nutos.2024.10.002","url":null,"abstract":"<div><h3>Background and aims</h3><div>One-third of the country suffers from metabolic dysfunction-associated fatty liver disease (MAFLD) due to unhealthy, improper dietary habits and sedentary lifestyles. This study aimed to explore the specific diet and lifestyle factors responsible for MAFLD.</div></div><div><h3>Methods</h3><div>This case-control study was conducted among the source population (n=200 diagnosed with MAFLD criteria; n=100 healthy controls). Quantitative approaches, such as interviews, were applied to measure dietary practices and physical activity levels.</div></div><div><h3>Results</h3><div>Most (89.5%) of the MAFLD patients were obese, used to sedentary lifestyles (56.0%), and took outside foods (58.5%) than their counterparts (P&lt;0.001). Moreover, nutrient intake analysis/day depicted that MAFLD patients consumed significantly higher amounts of total energy (2288.8 vs. 1570.8 kcal/day), calories from rice (1003.6 vs.795.2 Kcal/day), carbs (335.2 vs. 198.8 g/day), protein (97.9 vs. 85.9 g/day), fat (61.8 vs. 48.0 g/day) than controls. Nevertheless, 86.5% of MAFLD patients consumed a surplus of +268.6 kcal/day, indicating energy was not burnt through physical activities, while 89.0% of controls have negative energy balance (-360.4 kcal/day). Multivariable analyses revealed that &gt;300 minutes sitting times (aOR=8.6), &gt;300 g/day carbohydrate consumption (aOR=6.9), &gt;950 kcal/day from rice (aOR=2.2), &gt;50 g/day fat (aOR=2.9), ≤2000 Kcal/day energy-expenditure (aOR=2.9), BMI &gt;25 kg/m² (Adjusted odds ratio=aOR=16.1)<strong>,</strong> eating outside (aOR=7.4), being housewives (aOR=4.89), service-holders (aOR=4.12), &gt;31 age group (aOR=2.9), are significant risk factors for MAFLD.</div></div><div><h3>Conclusion</h3><div>Longer sitting times, outside eating habits, more energy from carbohydrates, especially rice, and a daily positive energy balance lead to obesity and, consequently, an increased risk of MAFLD.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 275-288"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-caffeine green tea supplementation reduced lithium serum levels and the relative abundance of microbiota in women with obesity: A case study","authors":"Natália Yumi Noronha ,&nbsp;Guilherme da Silva Rodrigues ,&nbsp;Vanessa Fernandes Rodrigues ,&nbsp;Carolina Ferreira Nicoletti ,&nbsp;Luzânia dos Santos Martins ,&nbsp;Luísa Maria Diani ,&nbsp;Heitor Bernardes Pereira Delfino ,&nbsp;Marcela Augusta de Souza Pinhel ,&nbsp;Lígia Moriguchi Watanabe ,&nbsp;Wellington Tavares de Sousa Júnior ,&nbsp;Déborah Araújo Morais ,&nbsp;Fernando Barbosa Júnior ,&nbsp;Fabiani Gai Frantz ,&nbsp;Daniela Carlos ,&nbsp;Carla Barbosa Nonino","doi":"10.1016/j.nutos.2024.09.012","DOIUrl":"10.1016/j.nutos.2024.09.012","url":null,"abstract":"<div><h3>Background</h3><div>Green tea (GT) polyphenols play an important and known role in the oxidative and inflammatory response due to their antioxidant, anti-inflammatory, anti-hyperglycemic, and anti-obesity properties. However, its relation to the detoxification of toxic metals and its possible effect remains unknown.</div></div><div><h3>Purpose</h3><div>The present study investigated the relationship between GT intake, toxic metals detoxification, and gut microbiota in obesity.</div></div><div><h3>Methods</h3><div>Each participant in the group initially received 56 capsules of low-caffeine GT from the Solaray® brand. After four weeks of supplementation, another 56 capsules were given, totaling 112. All assessments were performed pre- and post-GT intervention. Serum metal levels were determined using an inductively coupled plasma mass spectrometer (PerkinElmer, NexION 2000 B, Waltham, MA, EUA, EUA). Fecal DNA was extracted using the QIAmp® Fast DNA Stool MiniKit (QIAGEN).</div></div><div><h3>Results</h3><div>Intervention with GT did not promote changes in the clinical or metabolic data evaluated. However, GT supplementation led to a significant decrease of 48% in Lithium concentration in the post-intervention period compared to the pre-intervention period. This study also observes the prebiotic effect of green tea in modulating <em>Bacteroidetes</em> and <em>Firmicutes</em>.</div></div><div><h3>Conclusions</h3><div>The GT effect of Lithium reduction is a new finding in the literature. There is a lack of investigation to address the effects of the components of the GT in lithium excretion, and we attribute this effect to the trace amount of caffeine.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 252-264"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}