Clinical Nutrition Open Science最新文献

{"title":"The dietetic practice of prescribing amino acid-based formulas in paediatrics patients without cow's milk allergy: A single centre retrospective study","authors":"Graeme O'Connor ,&nbsp;Melissa Mansell","doi":"10.1016/j.nutos.2025.02.004","DOIUrl":"10.1016/j.nutos.2025.02.004","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Although there is a comprehensive pathway for prescribing amino acid-based (elemental) formulas (AAF) in paediatric patients with cow's milk allergy (CMA), there is a paucity of evidence-based practice for prescribing AAFs in patients without CMA. Gastrointestinal symptoms are some complications that can occur in enteral tube-fed patients, to mitigate these symptoms an AAF may be prescribed. AAFs contain macronutrients that have been enzymatically hydrolysed, requiring minimal digestion and promoting optimal absorption. The primary aim of this retrospective study was to ascertain the dietetic practice of prescribing AAFs to enteral tube-fed paediatric patients without CMA. Secondary outcomes measured weight change at 1 month and 6 months after AAF was prescribed and the incidence of hypophosphatemia at 6 months.</div></div><div><h3>Methods</h3><div>This is a single-centre, retrospective review of paediatric patients prescribed an AAF at a tertiary paediatric hospital between July 2023 and July 2024. Ethical approval was granted by ANONYMISED Audit, Quality Improvement and Service Evaluation Committee: registration number GOSH2024/3834. Inclusion criteria were patients aged between 0 and 16 years old who had been prescribed an AAF as part of their enteral nutrition, providing at least 80% of their estimated energy requirements for any condition other than allergic disease. Exclusion criteria were patients with confirmed immunoglobulin (Ig)E or non-IgE mediated CMA or multiple food allergies, eosinophilic gastrointestinal disease, and Food protein-induced enterocolitis syndrome. Data were collected on demographics, anthropometrics, feed regimens, gastrointestinal symptoms, proton pump inhibitor use and serum phosphate concentration.</div></div><div><h3>Results</h3><div>203 children were prescribed an AAF during the data collection period, of these, 154 of 203 (76%) patients had no allergies. Patients with gastrointestinal symptoms were the most common reason for commencing an AAF, 76 of 154 (49%) patients. The median age of patients prescribed AAF was 5.5 (IQR 1.3–9.8) years old. Patients displaying upper or lower gastrointestinal symptoms were the most common reason dietitians prescribed an AAF, 76 of 154 (49%) patients. 44 of 154 (28%) patients prescribed an AAF had a neurological impairment as a primary diagnosis. Dietitians prescribed AAFs as a first-line formula to transition patients off parenteral nutrition in 26 of 154 (17%) patients. 23 of 154 (15%) patients were prescribed an AAF after developing mucositis post high-dose chemotherapy. AAF was also prescribed in patients post cardiac and gastrointestinal surgery, protein-losing enteropathy, and gastrointestinal dystonia. The mean weight-for-age Z-score significantly improved in patients prescribed AAF from -3.7 (1.6SD) at baseline to -2.5 (1.5SD) at 6 months (<em>P</em>-value 0.001). After 6 months of receiving an AAF, there was no increased probabili","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 101-110"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of dysgeusia on sensory perception, appetite, and texture during oral nutritional supplement consumption in head and neck cancer and multiple myeloma patients","authors":"Ghias Kulsoom ,&nbsp;Krawczyk Janusz ,&nbsp;Gupta Ananya","doi":"10.1016/j.nutos.2025.01.008","DOIUrl":"10.1016/j.nutos.2025.01.008","url":null,"abstract":"<div><div>Dysgeusia, an altered taste perception commonly experienced by cancer patients undergoing chemotherapy or radiotherapy, significantly impacts their sensory perception, appetite, and compliance with oral nutritional supplements (ONS), essential for managing malnutrition. This unique study investigates how dysgeusia affects taste and texture perceptions during ONS consumption in this cohort, employing Temporal Dominance of Sensations (TDS) and Check-All-That-Apply (CATA) methods to capture dynamic sensory responses. Sixty-one cancer patients (31 with dysgeusia, 30 without) evaluated five sequential sips of a neutral-flavoured ONS, rating taste and texture using CATA and assessing liking, thirst, hunger, and fullness on hedonic and Visual Analogue Scales.</div><div>Our findings indicate that dysgeusia patients reported heightened perceptions of sweet, caramel, vanilla, and creamy attributes, while non-dysgeusia patients favoured more fluid and neutral textures like runny and viscous. Dysgeusia patients consistently selected more intense flavours and smoother textures, correlating with reduced hunger and increased thirst across sips, suggesting a sensory-specific response to repeated ONS intake (p &lt; 0.05). Notably, dysgeusia patients demonstrated a heightened perception for creamy and silky textures, potentially alleviating sensory discomfort associated with unpleasant metallic or bitter aftertastes. Dysgeusia also influenced fullness and hunger perceptions, impacting overall appetite regulation and adherence to ONS (p &lt; 0.05).</div><div>The study underscores the importance of tailoring ONS formulations to accommodate the altered sensory profiles of cancer patients with dysgeusia, optimizing palatability to improve compliance and nutritional outcomes. Findings also highlight the utility of CATA and TDS in this cancer cohort, providing comprehensive insights into dynamic sensory perceptions and supporting the development of personalized nutritional interventions. This research contributes novel insights into the sensory experience of dysgeusia patients, emphasizing the need for enhanced ONS formulations to meet their unique nutritional requirements and improve their quality of life.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 218-235"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The consumption of fast food and obesity associated with hypertension among restaurant workers in Jordan","authors":"Shayma Taha ,&nbsp;Madi Al-Jaghbir ,&nbsp;Mahmoud Abughoush ,&nbsp;Amal Aljanada","doi":"10.1016/j.nutos.2025.02.003","DOIUrl":"10.1016/j.nutos.2025.02.003","url":null,"abstract":"<div><h3>Background</h3><div>Fast food consumption among those who work in restaurants is a regular occurrence. Frequent consumption of high-caloric foods is a leading cause of obesity which is also a modifiable factor of risk for hypertension. Studies predict that the prevalence of hypertension would rise by 7.2% by 2030 compared to 2013 projections, demonstrating the urgent need for treatments to address the etiology of hypertension.</div></div><div><h3>Objective</h3><div>This study's primary objective is to investigate how fast-food intake, portion size, obesity, and hypertension are related among Amman, Jordan, restaurant workers.</div></div><div><h3>Methods</h3><div>A descriptive quantitative cross-sectional design was applied to investigate whether or not there is an association between obesity, regular intake of fast food, and high blood pressure among employees in the food services industry. A convenience sample of 386 restaurant employees was recruited from various restaurants in Amman, Jordan. A self-administered questionnaire that asked about food products, frequency of consumption, and the portion size was used to gather the data. An electric blood pressure monitor was used to track the sample's blood pressure while anthropometric measurements were obtained to determine height and weight. Chi-square test and Spearman rank-ordered correlation approach were used for the study.</div></div><div><h3>Results</h3><div>The analysis tests indicate that there is a significant positive correlation between the frequency of fast-food consumption and hypertension (rbp = 0.513, <em>P</em> &lt;0.001). The second correlation test analysis indicates that there is a significant positive correlation between the portion size of fast food and body mass index (rs = 0.529, <em>P</em> &lt;0.001). Moreover, there's a significant positive correlation between the age groups and hypertension (X2=27.686, <em>P</em>&lt;0.001), a significant positive association between obesity and the males of the participants (X2=33.134, <em>P</em>&lt;0.001), and a significant positive association between obesity and age groups (X2=32.132, <em>P</em>&lt;0.001).</div></div><div><h3>Conclusions</h3><div>The significant association between fast food, obesity, and hypertension among restaurant workers points out that fast food consumption is related to high rates of developing obesity and hypertension among restaurant workers. Data should be used by both health experts and management in the development of workplace health interventions that put an emphasis on restaurant employees.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 141-154"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fibre intervention in Hashimoto's thyroiditis patients and its impact on the gut microbiota","authors":"Zhang Jiayin ,&nbsp;Zhang Meizhu ,&nbsp;Zhang Yi ,&nbsp;Zhang Jie","doi":"10.1016/j.nutos.2025.02.002","DOIUrl":"10.1016/j.nutos.2025.02.002","url":null,"abstract":"<div><h3>Background and objectives</h3><div>There is currently a lack of effective methods for treating Hashimoto's thyroiditis (HT) patients with normal thyroid function. The microbiota is one of the factors affecting the thyroid gland. Dietary fibre (DF) can promote intestinal health and regulate the gut microbiota. This study evaluated the clinical efficacy of DF in treating HT and further explored the impact of DF on the gut microbiota.</div></div><div><h3>Methods and study design</h3><div>To investigate the effects of DF supplementation on HT patients, we conducted a randomized controlled trial (RCT) with 70 patients and an exploratory cohort study with 45 patients (included among the 70 patients in the RCT) with HT to investigate the potential impact of DF on the gut microbiota.</div></div><div><h3>Results</h3><div>After intervention with DF supplements, the antithyroid peroxidase antibody (TPOAb), antithyroglobulin antibody (TgAb), and IL-10 levels decreased, and the thyrotropin (TSH) level increased. However, the differences in Tumor necrosis factor alpha (TNF-α) were not significant. There was no difference in α-diversity or β-diversity. However, in the DF group, the abundances of <em>Xylanophilum</em> and <em>Parabacteroides</em> increased, whereas the abundance of <em>Erysipelatoclostridium</em> decreased. The functional features differed between the two groups. In the DF group, the composition of the DF group microbiota and metabolic functions changed before and after intervention.</div></div><div><h3>Conclusions</h3><div>The gut microbiota of HT patients shares common characteristics, but DF can cause changes in some gut microbiota, which are correlated with several clinical indicators. Thyroid hormones also affect the gut microbiota of HT patients and are associated with several predicted functions.</div></div><div><h3>Trial registration</h3><div>This study was registered in the international traditional medicine clinical trial registry (ITMCTR) (registered code: ITMCTR2024000463) (time of registration: 2024/08/24).</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 250-261"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing conflict of interests/consent statements in previously published articles","authors":"","doi":"10.1016/j.nutos.2025.01.015","DOIUrl":"10.1016/j.nutos.2025.01.015","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Page 21"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy drinks exacerbate high-fat diet-induced metabolic and hepatic dysfunction in male and female Wistar rats","authors":"Worship Odosa Agbonifo ,&nbsp;Joseph Chimezie ,&nbsp;Mercy Oluwaseun Awoleye ,&nbsp;Hope Oluwabukola Francis ,&nbsp;Temitope Gabriel Adedeji","doi":"10.1016/j.nutos.2025.01.012","DOIUrl":"10.1016/j.nutos.2025.01.012","url":null,"abstract":"<div><div>The global increase in non-communicable diseases, particularly those linked to obesity and metabolic disorders, is increasingly associated with high-fat diets (HFD) and the rising consumption of energy drinks (ED). This study examines the combined effects of these dietary factors on metabolic health and liver function using male and female Wistar rats. Sixty-four rats (32 males and 32 females) were divided into four dietary groups-control, control + ED, HFD, and HFD + ED, and observed over 12 weeks. At the end of the treatment period, various parameters were assessed, including body anthroprometrics, lipid profile, antioxidant activity, liver function, glucose and insulin levels, leptin levels, intraperitoneal glucose tolerance, and liver histology.</div><div>The results indicated that female rats in the HFD + ED group experienced increased BMI and elevated leptin levels, suggesting enhanced adiposity and potential leptin resistance. Male rats showed muscle mass gains without corresponding increases in BMI, indicating a different metabolic response to caloric intake. Significant increases in serum SOD and CAT levels were observed in female rats, alongside elevated CAT levels in male rats, pointing to a compensatory response to oxidative stress. Additionally, increases in liver function parameters ALT and ALP, particularly in female rats, indicated liver damage. Total protein levels were also decreased in female Wistar rats, suggesting reduced protein synthesis. Histological analysis confirmed hepatic injury, which was exacerbated by the combined intake of HFD and ED. These findings demonstrate that the combined intake of a high-fat diet and energy drinks leads to significant metabolic disruptions and liver damage in Wistar rats.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 111-140"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A genome-wide study of the effect of alcohol consumption on the risk of type 2 diabetes","authors":"Ariane Belzile ,&nbsp;Sam Pedro Galilée Ayivi ,&nbsp;Géraldine Asselin ,&nbsp;Sylvie Provost ,&nbsp;Louis-Philippe Lemieux Perreault ,&nbsp;Marie-Christyne Cyr ,&nbsp;Marie-Pierre Dubé","doi":"10.1016/j.nutos.2025.02.001","DOIUrl":"10.1016/j.nutos.2025.02.001","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>The relationship between alcohol consumption and type 2 diabetes risk is often described as a J- or U-shaped curve, with moderate drinkers having a lower risk compared to non-drinkers and heavy drinkers. However, this protective effect appears to be more pronounced in women than in men, suggesting a potential interaction between sex-specific factors and alcohol metabolism.</div></div><div><h3>Methods</h3><div>We conducted an interaction genome-wide association study (GWAS) to identify genetic variants that modify the relationship between alcohol consumption and type 2 diabetes risk in a sex-specific manner. We utilized data from the UK Biobank in a case-control approach including 309,568 individuals to investigate the three-way interaction between genetic variants, alcohol consumption, and sex on type 2 diabetes risk.</div></div><div><h3>Results</h3><div>We identified genetic variant rs78681203, located between the <em>FOXO6</em> and <em>EDN2</em> genes, with a significant sex-specific interaction with alcohol consumption (interaction p = 2.85 × 10⁻⁸). The T allele of rs78681203 was associated with an increased risk of type 2 diabetes in women consuming 0 to &lt;4 UK units/week (OR = 1.19, 95% CI: 1.07–1.34) but had a protective effect in women consuming 4 to &lt;28 UK units/week (OR = 0.81, 95% CI: 0.69–0.95). Conversely, in men, the T allele was associated with a higher risk of type 2 diabetes in the 4 to &lt;28 UK units/week group (OR = 1.19, 95% CI: 1.08–1.32) and had a protective effect in the 0 to &lt;4 UK units/week group (OR = 0.85, 95% CI: 0.74–0.99).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that genetic variation may play a role in the differential effects of alcohol consumption on type 2 diabetes risk between men and women. Further replication and mechanistic studies are needed to confirm and clarify the role of the identified genetic variant.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 78-88"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Mediterranean diet and high-intensity interval training on inflammatory markers in obese and overweight premenopausal women: A controlled trial","authors":"Mohammadreza Rabiee ,&nbsp;Razieh Hosseini ,&nbsp;Raziye Tahmasebi ,&nbsp;Maryam Koushkie Jahromi ,&nbsp;Sasan Amanat","doi":"10.1016/j.nutos.2025.01.006","DOIUrl":"10.1016/j.nutos.2025.01.006","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to investigate the effect of eight weeks of Mediterranean Diet (MedDiet) and high-intensity interval training (HIIT) on inflammatory markers in obese and overweight premenopausal women.</div></div><div><h3>Methods</h3><div>In this trial, 47 overweight and obese women were randomly divided into 4 groups: MedDiet group without calorie restriction (n = 14), HIIT group (n = 12), MedDiet + HIIT group (n = 12), and control group (n = 9). HIIT training sessions were carried out for 8 weeks, 3 sessions per week. In HIIT group, participants were instructed to maintain their usual diet. The participants in MedDiet program and Med Diet + HIIT groups were instructed to follow the principal aspects of MedDiet without caloric restriction. The serum level of IL-6 and adiponectin were measured using ELISA kits and serum CRP concentrations were determined by Turbidometery.</div></div><div><h3>Results</h3><div>The results showed that HIIT had no effect on the studied indices. Furthermore, MedDiet and HIIT together significantly increased the serum level of interleukin-6 (<em>P</em> = 0.00). While there were no significant changes in CRP (<em>P</em> = 0.72) and adiponectin (<em>P</em> = 0.16) between the groups at the end of the study.</div></div><div><h3>Conclusion</h3><div>Taken together, the results of this study demonstrated that a combination of the MedDiet and HIIT can be associated with a significant increase in IL-6. However, the current findings did not support alteration in adiponectin and CRP.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 155-162"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-calorie low-protein dietary pattern among overweight and obese pregnant women in Tanzania","authors":"Jacktan J. Ruhighira ,&nbsp;Ikunda Dionis ,&nbsp;Mariam Munyogwa ,&nbsp;Alexander M. Tungu ,&nbsp;Fredirick L. Mashili","doi":"10.1016/j.nutos.2025.01.014","DOIUrl":"10.1016/j.nutos.2025.01.014","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Traditionally, addressing underweight during pregnancy has been a priority in low-middle-income countries, including Tanzania. However, due to ongoing lifestyle and socioeconomic transitions, increasing rates of overweight and obesity have created a double burden of malnutrition (undernutrition and overnutrition). As a result of this transition, pregnancy-related weight gain tends to be excessive among women who are overweight or obese and does not adequately reverse after childbirth. This study aimed to explore the dietary patterns and macronutrient intakes of pregnant women with pre-pregnancy overweight or obesity and compare them with their normal-weight counterparts.</div></div><div><h3>Methods</h3><div>We consecutively recruited 242 pregnant women attending antenatal clinics in Dodoma, Tanzania. Dietary intake and patterns were assessed using 179-item food frequency questionnaires (FFQ). The Tanzanian food composition tables were then used to calculate nutrient and energy intake. We used principal component analysis (PCA) to identify dietary patterns. Energy and nutrient intake comparisons were made using the Mann–Whitney U test for independent analysis of medians and the Wilcoxon matched-pairs signed-rank test. Proportions were used to categorise protein, carbohydrate, and fat intakes below, within, or beyond recommendations.</div></div><div><h3>Results</h3><div>We identified six dietary patterns that accounted for 63% of the total variance in descending order of contribution as follows: nuts-cereals-legumes (24%); roots–plantains–fruits (10%); poultry–milky–meat (9%); fats-alcohol-eggs (8%); soda–sweets–meat (7%); vegetables–fish–legumes (6%). Energy intake was higher than recommended (z = 6, <em>P</em> &lt; 0.001), with % carbohydrate contribution higher than recommended among most participants (81%, n = 197). Although patterns rich in poultry, dairy, and meat were relatively more common among overweight and obese than normal–weight women, about 28% of them had a protein intake below the recommended.</div></div><div><h3>Conclusions</h3><div>Overweight and obese participants had a higher caloric intake with a greater % of carbohydrate contribution than recommended, and others consumed alcohol during pregnancy. A substantial proportion had a protein intake below the recommended.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 89-100"},"PeriodicalIF":0.0,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143388417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a food-related quality of life questionnaire (CANUT-QVA) for cancer patients","authors":"Kenza Drareni ,&nbsp;Catherine Mercier ,&nbsp;Reisya Rizki Riantiningtyas ,&nbsp;Anestis Dougkas ,&nbsp;Benjamin Riche ,&nbsp;Pascale Roux ,&nbsp;Chantal Fingal ,&nbsp;Hélène Labrosse ,&nbsp;Fadila Farsi ,&nbsp;David Dayde ,&nbsp;Mélanie Roche ,&nbsp;Julie Anne Nazare ,&nbsp;Arnaud Fournel ,&nbsp;Delphine Maucort-Boulch ,&nbsp;Moustafa Bensafi ,&nbsp;Véronique Mourier ,&nbsp;Amandine Bruyas ,&nbsp;Agnès Giboreau","doi":"10.1016/j.nutos.2025.01.001","DOIUrl":"10.1016/j.nutos.2025.01.001","url":null,"abstract":"<div><h3>Background</h3><div>Monitoring the psychosocial, emotional, and hedonic aspects of food behaviour is important for understanding cancer patients' distress and reducing the risk of malnutrition. However, there is no specific tool to measure food-related quality of life of cancer patients. This study aimed to develop and validate a questionnaire that assesses food-related quality of life in cancer patients.</div></div><div><h3>Methods</h3><div>Relevant items from existing food-related quality of life assessment tools were selected to compose the present 46-item questionnaire. The questionnaire was validated in 276 healthy controls and 173 cancer patients. Exploratory Factor Analysis (EFA) and multiple correspondence analysis were performed for both groups to determine construct and discriminant validity. Analysis of test-retest reliability was also performed to evaluate reproducibility.</div></div><div><h3>Results</h3><div>Out of the 46 items, 39 items showed significant differences between patients and healthy controls. The EFA allowed the identification of 9 factors in the food-related quality of life: 1. Cooking enjoyment/COOK; 2. Attention to nutrition/NUTRI; 3. Attention to meal quality and variety/QUAL; 4. Adaptive dietary practices/ADAPT; 5. Hedonic appreciation/HEDO; 6. Sensory alteration/ALT-SENS; 7. Meal experience/ALT-MEAL; 8. Altered digestion/ALT-DIGE; and 9. Dining &amp; commensality/SOCIO. Four subscores (ADAPT, ALT-SENS, ALT-MEAL, ALT-DIGE) exhibited significant discriminant validity across controls and patients. ALT-SENS (<em>p=</em>0.016), ALT-MEAL (<em>p=</em>0.04), and ALT-DIGE (<em>p=</em>0.009) were higher in patients undergoing chemotherapy compared to patients not undergoing chemotherapy. The questionnaire showed good test-retest reliability.</div></div><div><h3>Conclusions</h3><div>This questionnaire offers valuable insights for clinical research on the impact of cancer on patients' relationships with food.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 143-158"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}