Clinical Nutrition Open Science最新文献

{"title":"Nutritional status and associated factors among adolescent girls attending high schools in Jigjiga, Ethiopia","authors":"Mahamed Abdulahi Ahmed ,&nbsp;Abdulkarim Mohamed Ali ,&nbsp;Shamsedin Mahdi Hassan ,&nbsp;Hassen Mahamed Jerar","doi":"10.1016/j.nutos.2025.05.005","DOIUrl":"10.1016/j.nutos.2025.05.005","url":null,"abstract":"<div><div>Adolescent schoolgirls' nutritional status and dietary habits are crucial indicators of their current and future health outcomes. This study assessed the sociodemographic, socio-economic, nutritional status, dietary patterns, physical activity, lifestyle, and health conditions of 148 schoolgirls in the Somali Region, Ethiopia. A structured questionnaire and anthropometric measurements were used to collect data. Descriptive statistics were applied for data analysis. The study found that 14.9% of the schoolgirls were undernourished based on their Body Mass Index (BMI), indicating a significant public health concern. Furthermore, 58.8% of respondents reported experiencing significant weight fluctuations in the past year, and only 52% consumed three meals per day, while 35.1% skipped breakfast. Fruit and vegetable consumption was low, with only 32.4% consuming them daily. Fast food consumption was high (69.6%), with sanbusa being the most common. Physical inactivity was prevalent, with 50% of respondents reporting no engagement in physical activity during the week, and 78.4% not participating in organized sports. About 31.1% consumed carbonated and energy drinks daily, while 66.2% reported experiencing pre-menstrual syndrome. Knowledge, attitude, and practices around nutrition were mixed: only 15.5% claimed to have a lot of knowledge about the nutritional value of food, and while 93.2% recognized nutrition's importance for health, 39.2% felt they lacked adequate information about healthy eating. The findings reveal critical nutritional and lifestyle challenges among schoolgirls, including undernutrition, low dietary diversity, high fast-food and sugary drink consumption, limited physical activity, and insufficient dietary knowledge. These results underscore the need for targeted interventions to promote healthier eating habits, increase nutrition education, and encourage physical activity among adolescent girls to improve their overall health and well-being.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 11-25"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144194716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing nutritional support: A quality improvement project for cancer patients undergoing anti-cancer treatment at the National Center for Cancer Care and Research, Qatar","authors":"Shaikhah Al-Keldi ,&nbsp;Zainab Tayyem ,&nbsp;Azar Naveen ,&nbsp;Ayman Allam ,&nbsp;Hodan Abdullah ,&nbsp;Zeinab Idris ,&nbsp;Hiba Eltahir ,&nbsp;Rumana Khanum ,&nbsp;Lamiaa Saleh ,&nbsp;Azza Hassan","doi":"10.1016/j.nutos.2025.05.006","DOIUrl":"10.1016/j.nutos.2025.05.006","url":null,"abstract":"<div><h3>Background</h3><div>Cancer patients often suffer from malnutrition related symptoms which can greatly affect their health and treatment outcomes. A screening pilot study was conducted, involving the random selection of 100 patients with specific cancer types at Day Care Unit (DCU). Risk of malnutrition was evaluated using the Malnutrition Screening Tool (MST), with scores of 2 and above indicating risk of malnutrition. The study found that over 85% of the patients were at high risk of malnutrition, emphasizing the necessity for intervention. To tackle this problem, a quality improvement was launched at DCU at National Center for Cancer Care and Research (NCCCR) in Qatar.</div></div><div><h3>Aim</h3><div>The aim of this project is to optimize the nutritional status of patients at risk of malnutrition who are receiving anti-cancer treatment at DCU by appropriate screening, assessment and interventions using the standardized MST by the end of June 2023.</div></div><div><h3>Methods</h3><div>A quality project was launched and 102 patients diagnosed with specific types of cancer and MST scores of 2 and higher were enrolled. These patients underwent personalized dietary assessments, received nutritional counselling and were provided with customized dietary plans and supplements tailored to their requirements. The effectiveness of these interventions was evaluated at 3 points: baseline, the 4^th week, and 8^th week.</div></div><div><h3>Results</h3><div>The outcomes of this project were encouraging. Out of 102 patients, 68% displayed notable enhancement in nutrition (<em>P</em>=0.001), evidenced by MST scores below 2 during the 4^th week follow-up assessment. This improvement persisted into the 8^th week, with 67% of patients still showing progress (<em>P</em>=0.001) indicated by MST scores below 2. Importantly, there were no significant differences in outcomes based on age or gender.</div></div><div><h3>Conclusion</h3><div>The project shows the impact of interventions on enhancing the nutritional well-being of cancer patients. It stresses the significance of nutrition screening and timely intervention, and the necessity for proper referral procedures to connect patients with dietitians within the DCU.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-hospital parenteral nutrition use: A cohort study of administrative and computational challenges","authors":"Marc Romain ,&nbsp;Charles Weissman ,&nbsp;Khuloud Abu-Tair ,&nbsp;Abdallah Alaaldein ,&nbsp;Rivki Harari ,&nbsp;Orit Bitner ,&nbsp;Alexander Furmanov ,&nbsp;Shaul Yaari","doi":"10.1016/j.nutos.2025.05.004","DOIUrl":"10.1016/j.nutos.2025.05.004","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Parenteral nutrition is a vital modality administered to patients with gastrointestinal tracts unable to support sufficient nutritional intake. We explored whether administrative and computational challenges encountered when analyzing in-patient parenteral nutrition use are similar to those found when analyzing critically ill patient activities.</div></div><div><h3>Methods</h3><div>A dataset containing 9 years of routinely collected administrative data from a healthcare system comprising tertiary care and community hospitals, was analyzed.</div></div><div><h3>Results</h3><div>Computational and administrative issues found when analyzing in-patient parenteral nutrition data were similar to those found when analyzing critical care data. Some patients had multiple hospital admissions so both the number of individual patients and admissions were quantified. In the tertiary facility 2,984 patients, admitted on 4,121 occasions, received parenteral nutrition for a total of 68,047 days; admission to patient ratio of 1.4. The ratio was 1.2 in the community hospital. Administrative challenges included changes in patient case-mix and medical staff. Computations showed the importance of carefully examining frequency distributions. Age distributions were bimodal, adult body-mass index distributions had Gaussian characteristics and parenteral nutrition administration duration distributions were rightward skewed because some patients received parenteral nutrition for extended periods. Therefore, median rather than mean durations represented central tendency. In the tertiary care institution, mean duration was 17.6 ± 26.1(SD) days but median was 12 days.</div></div><div><h3>Conclusion</h3><div>Parenteral nutrition is administered to heterogenous groups of patients hospitalized in different settings, suffering from various diseases and spanning all ages. Such heterogeneity requires paying attention to data characteristics and administrative issues when examining its in-hospital use.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 329-339"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional analysis of access to resources and its relationship with food security in vulnerable populations","authors":"Vilma Raffo-Babici ,&nbsp;Juan Calderon-Cisneros ,&nbsp;Dennis Peralta-Gamboa ,&nbsp;Arianna Coloma-Casanova","doi":"10.1016/j.nutos.2025.05.001","DOIUrl":"10.1016/j.nutos.2025.05.001","url":null,"abstract":"<div><div>The study addresses a multidimensional analysis of access to resources and its impact on food security in vulnerable populations.</div></div><div><h3>Method</h3><div>Advanced statistical methods are used to examine how different socioeconomic, geographic, and demographic factors influence food availability and quality in disadvantaged communities<strong>.</strong></div></div><div><h3>Background</h3><div>The research highlights the importance of variables such as household income, education, access to health services, and local infrastructure. In addition, environmental aspects that can affect food production and distribution are considered.</div></div><div><h3>Aim</h3><div>The aim is to identify patterns and relationships that can inform more effective public policies and intervention strategies to improve food security.</div></div><div><h3>Results</h3><div>The results suggest that unequal access to critical resources is a determining factor in food insecurity and that addressing these disparities can lead to significant improvements in the quality of life of vulnerable populations.</div></div><div><h3>Conclusion and policy implications</h3><div>This analysis provides a solid foundation for future research and actions aimed at ensuring equitable access to essential resources, thereby promoting greater resilience and sustainability in these communities. By integrating education, infrastructure, and cultural preservation into food security programs, policymakers can create sustainable and impactful solutions.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 317-328"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and coexistence of malnutrition, sarcopenia, frailty and sarcopenic obesity among older adults in the community: Results from a prospective cohort study","authors":"Zhishan Jiang,&nbsp;Adrian Slee,&nbsp;Christine Elizabeth Weekes","doi":"10.1016/j.nutos.2025.05.003","DOIUrl":"10.1016/j.nutos.2025.05.003","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background &amp; aims&lt;/h3&gt;&lt;div&gt;Advanced age is an independent risk factor for malnutrition, sarcopenia, frailty and sarcopenic obesity (MSFSO), and each condition is associated with adverse outcomes, such as higher risk of morbidity and mortality, higher incidence of hospitalization, increased risk of falls and disability, poorer quality of life (QOL), and greater use of health and social care resources. Some characteristics overlap between MSFSO, yet there is a lack of research into the coexistence of these conditions currently. Therefore, this study aimed to explore the prevalence and coexistence of MSFSO among older adults in different community settings, to identify potential associated factors, and to examine its associations with mortality, QOL and contacts with health and social care professionals (HSCPs).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Data were retrieved from a prospective cohort study, recruiting older adults (≥60 years of age) from community settings. Baseline characteristics from two settings, general practice (GP) and intermediate care (IC), were analyzed in this study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;347 participants were analyzed (57% females, mean age 77 ± 9 years, mean body mass index 25.8 ± 5.7 kg/m&lt;sup&gt;2&lt;/sup&gt;), with 52% from GP and 48% from IC. The prevalence rates were 21.6% for malnutrition, 50.1% for sarcopenia, 49.3% for frailty, and 12.1% for sarcopenic obesity. More than half of the subjects (53.8%) experienced at least one of the above conditions, with 4 participants (1.3%) suffering from all four conditions simultaneously. The IC cohort was older and had a poorer health status compared to the GP population, resulting in a significantly higher prevalence of malnutrition (41.5% vs. 7.9%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), sarcopenia (85.7% vs. 16.8%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), frailty (91.1% vs. 10.0%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001), sarcopenic obesity (17.9% vs. 7.3%, &lt;em&gt;P&lt;/em&gt; = 0.006) and coexisting MSFSO (83.7% vs. 12.4%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001). In addition, strong associations were observed between higher coexistence of MSFSO conditions and participants from the IC setting (IRR 4.12, 95%CI 3.06–5.56, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) or with more comorbidities (IRR 1.55, 95%CI 1.13–2.12, &lt;em&gt;P&lt;/em&gt; = 0.007). The majority of participants (90.3%, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) who subsequently died during the study had at least two conditions of MSFSO. Subjects with coexistence of MSFSO also had poorer perceived QOL (EQ-5D Visual Analogue Scale: none vs. ≥2 conditions = 85 scores vs. 56 scores, &lt;em&gt;P&lt;/em&gt; &lt; 0.001) and generally more contacts with HSCPs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Coexistence of MSFSO was associated with a greater risk of mortality, a poorer perceived QOL and an increased contact with health and social care services. Furthermore, people in the IC setting or with more comorbidities were more likely to experience a higher coexistence of MSFSO. The differences in characteristics and MSFSO prevalence rates bet","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 26-41"},"PeriodicalIF":0.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trial","authors":"Shaista Jabeen ,&nbsp;Azmat Ullah Khan","doi":"10.1016/j.nutos.2025.04.010","DOIUrl":"10.1016/j.nutos.2025.04.010","url":null,"abstract":"<div><div>Fundamental adherence to gluten-free diet can improve gastrointestinal symptoms. Substitution of wheat should be done in order to fulfil gluten-free criteria and nutrient density.</div></div><div><h3>Objective</h3><div>This study was conducted to assess the efficacy of gluten free cupcakes formulated by substitution of low FODMAP foods.</div></div><div><h3>Design</h3><div>Random parallel assignment was adopted (1b).</div></div><div><h3>Methods</h3><div>A 12 weeks efficacy trial was conducted on children of age 3–8 years, and were randomly allocated into two groups (n = 35 in each group). Gluten free cupcakes group was provided with gluten-free flour blend cupcakes (35 g), while placebo group was provided with rice flour-based cupcakes.</div></div><div><h3>Results</h3><div>Weight was significantly increased in both placebo (13.7 ± 4.8 to 14.5 ± 4.4) and gluten free (13.6 ± 4.6 to 15.4 ± 4.6) groups. Mid upper arm circumference was significantly increased in gluten free group only (15.3 ± 3 to 15.5 ± 3). Abdominal pain was reduced to 38.7% from 6.5% (absent) in the placebo group compared to gluten free group 15.2%–33.3% (absent), while diarrhea was reduced to 33.3% from 27.3%. Serum platelets were significantly reduced in gluten free cupcake group (GFC) from 308.4 ± 39.5 to 300.3 ± 38.7 (<em>P</em> &lt; 0.05). Tissue trans-glutaminase antibody (tTg-IgA) was significantly reduced from 148 ± 51 to 127 ± 31.</div></div><div><h3>Conclusion</h3><div>Formulated gluten-free cupcakes are found to be effective in improving gastrointestinal symptoms and anthropometrics in patients with celiac disease.</div></div><div><h3>ClinicalTrials.gov PRS</h3><div>Record Summary NCT06359613.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 307-316"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of age on change in intramuscular adipose tissue of the quadriceps is remarkable in older inpatients aged 85 and over","authors":"Naoki Akazawa ,&nbsp;Keita Funai ,&nbsp;Toshikazu Hino ,&nbsp;Wataru Tamura ,&nbsp;Kimiyuki Tamura ,&nbsp;Akemi Hioka ,&nbsp;Yasushi Uchiyama","doi":"10.1016/j.nutos.2025.05.002","DOIUrl":"10.1016/j.nutos.2025.05.002","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to examine the influence of age on change in intramuscular adipose tissue of the quadriceps in older inpatients.</div></div><div><h3>Methods</h3><div>This prospective study included 191 older inpatients (aged ≥65 years). We divided the participants into the following three age groups: 65–74 years (n = 29), 75–84 years (n = 80), and ≥85-years (n = 82). Intramuscular adipose tissue of the quadriceps was assessed based on quadriceps echo intensity. Greater intramuscular adipose tissue was indicated by higher echo intensity. The change in quadriceps echo intensity was calculated by subtracting this baseline value from the value at discharge. For comparing the changes in quadriceps echo intensity among the three groups, analysis of covariance adjusted for confounding factors was conducted. Multiple linear regression analysis was used to determine whether age was independently and significantly related to changes in quadriceps echo intensity.</div></div><div><h3>Results</h3><div>Change in quadriceps echo intensity of the aged ≥85-year group (−0.4 ± 12.1 [a.u.]) was significantly higher than that of the 65–74-year group (−6.4 ± 15.0 [a.u.]). Age was significantly and independently related to change in quadriceps echo intensity (β = 0.148, <em>P</em> = 0.036).</div></div><div><h3>Conclusions</h3><div>The results of this study indicate that higher age in older inpatients may negatively affect the decrease of intramuscular adipose tissue of the quadriceps. Especially, this trend is observed in older inpatients aged 85 and over.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 271-281"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could micronutrients influence levels of TNF-α expression? A nutrigenomics study through 8-WEEK dietary intervention","authors":"Isabelle Mello Schineider ,&nbsp;Natália Yumi Noronha ,&nbsp;Luzânia dos Santos Martins ,&nbsp;Vanessa Aparecida Batista Pereira ,&nbsp;Heitor Bernardes Pereira Delfino ,&nbsp;Rafael Fernandes Ferreira ,&nbsp;Lígia Moriguchi Watanabe ,&nbsp;Marcela Augusta de Souza Pinhel ,&nbsp;Guilherme da Silva Rodrigues ,&nbsp;Carla Barbosa Nonino","doi":"10.1016/j.nutos.2025.04.006","DOIUrl":"10.1016/j.nutos.2025.04.006","url":null,"abstract":"<div><h3>Background</h3><div>Obesity is associated with low-grade inflammation, which contributes to the pathogenesis of comorbidities such as diabetes mellitus, arterial hypertension, and dyslipidemia. Nutrient intake can increase anti-inflammatory mechanisms by modulation of immune response.</div></div><div><h3>Objectives</h3><div>To assess the impact of a hypocaloric diet on the gene expression of inflammatory markers and correlate it with nutritional variables to identify important factors in the modulation of inflammation.</div></div><div><h3>Methods</h3><div>20 women were evaluated and divided into 2 groups: Intervention Group IG (n=10), with women with grade III obesity. They received a hypocaloric diet for 8 weeks. The Total Energy Intake (TEI) was determined by subtracting 30% of the participants' Resting Energy Expenditure (REE) calculated through inderect calorimetry for each patient. The distribution of macronutrients was 55%–60% of the TEI of carbohydrates, 20%–25% of the TEI of total fat, and 15%–20% of the TEI of proteins. The micronutrients intake was determined by the Dietary Reference Intake (DRIs) according to age and sex. Control Group CG (n=10), with non-obese women. Nutritional assessment consisted of anthropometric parameters, body composition measurements, biochemical markers, and food intake. Gene expression analysis was performed.</div></div><div><h3>Results</h3><div>After the diet, the following variables decreased in IG: weight, BMI, fat mass, HDL-c, triglycerides, and <em>TNF-α</em> gene expression. Also, <em>TNF-α</em> gene expression was negatively correlated with omega-3, omega-6, iron, vitamin B1, vitamin B6, and vitamin B12 intake.</div></div><div><h3>Conclusion</h3><div>The hypocaloric diet over 8 weeks had a positive impact on anthropometric, biochemical, body composition, and gene expression parameters. Furthermore, the evaluated nutrients were correlated with the expression of <em>TNF-α</em>, showing the importance of diet in obesity treatment.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 297-306"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Nutrition in critical illness survivors: Why gaining a grip matters”","authors":"Elisabeth De Waele ,&nbsp;Zenzi Rosseel","doi":"10.1016/j.nutos.2025.04.008","DOIUrl":"10.1016/j.nutos.2025.04.008","url":null,"abstract":"<div><div>In this viewpoint, we explore the challenges and opportunities in nutritional therapy for patients in the post-ICU recovery phase. The complexity of metabolic alterations and organ dysfunction in critical illness highlights the need for individualized nutritional strategies. Current approaches to protein and energy dosing remain generalized, indicating a lack of phenotyping and endotyping. The transition from critical illness to recovery is a gradual process, with patients often spending extended periods in hospital wards after ICU discharge. We identify this post-ICU period as a crucial anabolic window for muscle regeneration and rehabilitation. However, there is a lack of clear guidance and strong evidence for nutritional therapy in post-ICU patients. Large studies and RCT's that investigate nutritional adequacy and the necessary follow-up are lacking. We call for dedicated research to develop intelligent approaches to post-ICU nutrition, leveraging new technologies including artificial intelligence, wearables and collaborative tools. Multidisciplinary teams are a key component in the post ICU recovery while the importance of interdisciplinary collaboration in addressing these challenges is clear. The incorporation of economic considerations in developing nutritional care strategies is important, as is the need for smart implementation strategies to improve nutritional care for ICU survivors. Enhanced care for ICU survivors could improve nutrition adequacy and with that decrease the incidence of malnutrition with lower readmissions and infections rates resulting in a lower economic burden. The focus in this article is the post ICU period but the rehabilitation period after discharge should not be overlooked. Finally, we conclude that through these efforts, we can significantly enhance the recovery and outcomes of patients transitioning from critical illness to rehabilitation.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 42-47"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An open-label clinical trial to investigate the safety and efficacy of a bone broth diet on weight loss in adults with obesity","authors":"Katarina M. Doma,&nbsp;Marc Moulin,&nbsp;Huda Al-Wahsh,&nbsp;Najla Guthrie,&nbsp;David C. Crowley,&nbsp;Erin D. Lewis","doi":"10.1016/j.nutos.2025.04.009","DOIUrl":"10.1016/j.nutos.2025.04.009","url":null,"abstract":"<div><h3>Background and aims</h3><div>Over 40% of North American adults are obese and with rates increasing, an already significant public health concern is expected to get worse. Modifiable risk factors such as poor dietary habits represent an opportunity for targeted change. The Bone Broth Diet (BBD) combines the consumption of bone broth, portion-controlled, low carbohydrate and high protein meals, intermittent fasting, and exercise.</div></div><div><h3>Methods</h3><div>This open-label, single-arm clinical trial investigated the safety and efficacy of the BBD on weight loss in adults with obesity between 35–65 years old. Participants (n = 100) completed two, 3-week periods of 5:2 intermittent fasting (BBD 1 and 2), while consuming bone broth, for which each period was followed by a one-week maintenance period. Body weight, body composition, anthropometrics, metabolic blood markers, satiety and hunger, quality of life, and safety were assessed over the study period.</div></div><div><h3>Results</h3><div>There were respective decreases of 4.8 kg and 2.6 kg in body weight after BBD 1 and 2 which corresponded to 5.0% and 2.7% (<em>P</em> &lt; 0.001), respectively. Both BBD phases were followed by periods of weight maintenance. These improvements corresponded with decreases in fasting blood glucose, waist circumference, and sagittal abdominal diameter (<em>P</em> ≤ 0.005). There were decreases in hunger and cravings (<em>P</em> &lt; 0.05) with no reduction in satisfaction after eating over the study period (<em>P</em> &gt; 0.05). The BBD was safe and tolerated in the studied population.</div></div><div><h3>Conclusion</h3><div>The BBD showed safe, statistically significant and clinically relevant weight loss with corresponding improvements in cardiometabolic and psychological health outcomes in a population of adults with obesity who were otherwise healthy. Findings suggest this lifestyle program may aid in addressing an important public health concern. However, future randomized controlled trials of longer duration are recommended to verify and understand the sustainability of results.</div></div><div><h3>Clinical trial registration</h3><div>This study is registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> (NCT05740670).</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"61 ","pages":"Pages 282-296"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}