Clinical Nutrition Open Science最新文献

{"title":"Determinants of animal source foods (ASFs) consumption among Somali children aged 6–23 months; evidence from the 2020 Somalia demographic and health survey; a multilevel mixed effect model analysis","authors":"Abdifatah Ibrahim Mouse ,&nbsp;Abdisalam Hassan Muse","doi":"10.1016/j.nutos.2026.100631","DOIUrl":"10.1016/j.nutos.2026.100631","url":null,"abstract":"<div><h3>Background</h3><div>Animal Source Foods (ASFs) provide high-quality protein and essential micronutrients critical for physical growth and cognitive development in young children. Inadequate consumption of ASFs during the complementary feeding period (6–23 months) contributes significantly to stunting and micronutrient deficiencies in developing regions. Despite the high burden of malnutrition in Somalia, there is a paucity of nationally representative data regarding ASF consumption patterns and their determinants among Somali children.</div></div><div><h3>Aims</h3><div>This study aimed to determine the magnitude of ASF consumption and identify individual and community-level determinants among children aged 6–23 months in Somalia.</div></div><div><h3>Methods and Materials</h3><div>A secondary analysis was conducted using data from the 2020 Somalia Demographic and Health Survey (SDHS). The study included a sample of 2,097 children aged 6–23 months. The outcome variable was the consumption of any ASF (meat, eggs, fish, organ meat, or dairy) in the 24 hours preceding the survey. A multilevel mixed-effects logistic regression model was fitted to identify significant predictors, reporting Adjusted Odds Ratios (AOR) with 95% Confidence Intervals (CI).</div></div><div><h3>Results</h3><div>The overall prevalence of ASF consumption was 64.9% (95% CI: 62.8–66.9%). However, consumption was heavily skewed towards fresh milk (45.5%), while intake of meat (11.2%), eggs (7%), and fish (4.7%) was low. Multivariable analysis revealed that children with media exposure (AOR = 1.60; 95% CI: 1.03–2.50) and those not currently breastfeeding (AOR = 1.75; 95% CI: 1.41–2.17) had higher odds of ASF consumption. Conversely, lack of maternal mobile phone ownership (AOR = 0.76; 95% CI: 0.58–0.99) and husband unemployment (AOR = 0.69; 95% CI: 0.55–0.86) were associated with lower consumption. Paradoxically, children from wealthier households (fourth quintile) had lower odds of consuming ASFs compared to the poorest households (AOR = 0.60; 95% CI: 0.43–0.85).</div></div><div><h3>Conclusion</h3><div>While the prevalence of ASF consumption appears moderately high, it is qualitatively limited by a heavy reliance on milk and a lack of solid animal proteins like meat and eggs. Socioeconomic factors, media access, and breastfeeding status significantly influence consumption patterns. Interventions should focus on promoting dietary diversification beyond milk through mass media campaigns and economic empowerment initiatives.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100631"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of zinc supplementation on serum concentration of lipid profile among children and adolescents: A systematic review on randomized controlled trials","authors":"Ali Gholami ,&nbsp;Fatemeh Azizi-Soleiman ,&nbsp;Mitra Hariri","doi":"10.1016/j.nutos.2026.100629","DOIUrl":"10.1016/j.nutos.2026.100629","url":null,"abstract":"<div><h3>Background</h3><div>New evidence suggests that zinc supplementation may significantly influence serum lipid profile levels and vascular health in children and adolescents. Therefore, this systematic review aims to investigate and summarize published data regarding the effects of zinc supplementation on lipid profiles in children and adolescents.</div></div><div><h3>Methods</h3><div>A systematic search was conducted across multiple databases, including the Cochrane Library, <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, ISI Web of Science, Scopus, and PubMed, up to May 2025. Search terms related to zinc, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG), children, adolescents, and clinical trials were identified using both Medical Subject Headings (MeSH) and non-MeSH terms. The search strategy employed asterisks, parentheses, quotation marks, and Boolean operators (AND/OR) to optimize retrieval of relevant studies.</div></div><div><h3>Results</h3><div>A total of five studies were included in this systematic review. Serum TG, LDL-C, and HDL-C levels were assessed in four studies, and TC levels in five studies. TC decreased in one study. TG and LDL-C levels showed significant reductions compared with placebo in two studies. A significant increase in HDL-C levels was observed in one study.</div></div><div><h3>Conclusion</h3><div>Zinc supplementation may be effective in improving lipid profiles among children and adolescents. However, further well-designed randomized clinical trials involving children and adolescents with varying health conditions, larger sample sizes, different zinc dosages, and longer follow-up periods are strongly recommended to confirm the effectiveness of zinc supplementation in this population.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100629"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting energy expenditure is not defined by bowel function among patients with intestinal failure","authors":"Caroline Amalie Krag ,&nbsp;Signe Amalie Schaaning Heuckendorff ,&nbsp;Alberte Schneevoigt Højrup ,&nbsp;Caroline Bang Pedersen ,&nbsp;Sabina Mikkelsen ,&nbsp;Marianne Køhler ,&nbsp;Henrik Højgaard Rasmussen ,&nbsp;Mette Holst","doi":"10.1016/j.nutos.2026.100630","DOIUrl":"10.1016/j.nutos.2026.100630","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Resting energy expenditure (REE) is a critical parameter for assessing energy requirements in patients with chronic intestinal failure (CIF). This study aimed to investigate the influence of intestinal functionality, defined by the need for parenteral nutrition (PN), on REE and to evaluate the accuracy of Harris-Benedict equation (HB-equation) used to estimate REE (eREE) in individuals with CIF.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted among patients diagnosed with CIF. Data collected was demographic information, body composition measured by bioelectric impedance analysis, measured REE (mREE) by indirect calorimetry and data from the patients’ medical records like pathophysiological mechanisms, underlying diseases, receiving PN or not, information related to nutritional risk and blood samples (CRP and albumin). Furthermore, eREE was calculated by the HB-equation.</div></div><div><h3>Results</h3><div>Overall, 201 patients were included (mean age: 61.8±14.8 years, sex: 65.0% female). There was a significant difference between patients with short bowel syndrome, other underlying pathophysiological mechanisms and other diseases <em>P</em>&lt;0.001. No significant difference was observed in overall mREE between patients receiving PN and those not receiving PN. However, significant differences were observed for REE/kg body weight, REE/kg muscle mass, and REE/kg fat free mass between patients receiving PN and those not receiving PN. REE was lower, when estimated compared to measured (<em>P</em>=0.003), and the group with SBS, cancer and those not receiving PN, had lower REE when estimated compared to measured (<em>P</em>&lt;0.05).</div></div><div><h3>Conclusion</h3><div>Intestinal functionality had no influence on REE, however REE/kg mass was higher in the PN-group for body weight, muscle mass and fat free mass. When comparing the HB-equation with IC, eREE was overall lower compared to mREE. This study emphasizes the need for more accurate equations to estimate REE in CIF patients, highlighting that IC is essential for precise measurement at present time.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100630"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thigh ultrasound is a valid measurement for sarcopenia and fat mass analysis in patients with cirrhosis","authors":"Reza Saeidi ,&nbsp;Neasa Mc Gettigan ,&nbsp;Marian Hanley ,&nbsp;Martina Morrin ,&nbsp;John Ryan ,&nbsp;Karen Boland","doi":"10.1016/j.nutos.2026.100628","DOIUrl":"10.1016/j.nutos.2026.100628","url":null,"abstract":"<div><h3>Aim and background</h3><div>Sarcopenia, defined as reduced muscle mass and strength, is associated with poor outcomes in cirrhosis. Severe sarcopenia includes low performance status. While CT imaging is the standard for assessing muscle mass, anterior thigh ultrasound (TUS) may offer a low-cost, bedside alternative. This study aimed to validate TUS—measuring total muscle thickness (TMT) and superficial fat (SF)—against bioelectrical impedance analysis (BIA), and to explore its relationship with the Liver Frailty Index (LFI).</div></div><div><h3>Method</h3><div>In this cross-sectional study, patients with cirrhosis were recruited from hepatology clinic and compared to healthy controls. TMT was measured at the midpoint between the patella and anterior superior iliac spine using B-mode ultrasound with minimal probe pressure. BIA (SECA mBCA 525) was the reference standard. Sarcopenia was diagnosed using the Sergi equation. Functional metrics (handgrip, sit-to-stand), LFI, and body fat percentage were also assessed.</div></div><div><h3>Results</h3><div>A total of 124 participants were included (87 cirrhotic, 37 controls). TMT ≤ 3.47 cm in men and ≤ 2.94 cm in women predicted sarcopenia with AUCs of 0.90 and 0.83, respectively. SF correlated with fat mass index in both sexes (rho = 0.61 in males and rho = 0.57 in females, <em>P</em> &lt; 0.001). LFI negatively correlated with TMT (rho = - 0.32, <em>P</em> = 0.002). No correlation was found between TMT or LFI and MELD or Child-Pugh scores.</div></div><div><h3>Conclusion</h3><div>TUS is a valid, bedside tool to detect sarcopenia and frailty in cirrhosis. TMT correlates with reduced muscle function, supporting its clinical utility in identifying high-risk patients.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100628"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of antioxidant supplementation containing selenium and vitamin E on male infertility: A systematic review and meta-analysis","authors":"Behnaz Sadeghzadeh Oskouei ,&nbsp;Parnian Rahimi ,&nbsp;Niusha Azimzadeh ,&nbsp;Azizeh Farshbaf-Khalili ,&nbsp;Soraya Babaie ,&nbsp;Aliasghar Khakpaki","doi":"10.1016/j.nutos.2026.100632","DOIUrl":"10.1016/j.nutos.2026.100632","url":null,"abstract":"<div><h3>Background</h3><div>Recent studies highlight the impact of oxidative stress on sperm quality and male fertility. Given the potential antioxidant effects of selenium and vitamin E, this systematic review and meta-analysis assessed the impact of antioxidant supplementation containing selenium and vitamin E (Se+Vit E) on male infertility.</div></div><div><h3>Methods</h3><div>A systematic search (Web of Science, Medline, Embase, Scopus, ProQuest, Cochrane Library through April 2025) identified 19 studies (11 single-arm, 7 randomized controlled trials (RCTs), 1 non-randomized) evaluating sperm quality, oxidative stress, and pregnancy rates. Methodological quality was assessed using Cochrane guidelines.</div></div><div><h3>Results</h3><div>Meta-analysis of data from 8 studies (736 participants) revealed that dual Se+Vit E supplementation enhanced motility (mean difference [MD]: 13.56%, 95%CI: 0.16–0.81; <em>P</em>=0.001; I²=41%), normal morphology (MD: 0.69%, 95%CI: 0.27–1.11; <em>P</em>=0.001; I²=0%), and vitality (MD: 23.24%, 95%CI: 16.66–29.82; <em>P</em>&lt;0.00001; I²=41%). The sperm motility also increased in total (dual Se+Vit E in addition to antioxidants containing Se+Vit E) (13.56%, 95%CI: 0.16–0.81; <em>P</em>=0.001; I²=41%). No significant effects were observed on semen volume, sperm count, sperm concentration, or DNA fragmentation index (DFI) following dual Se+Vit E supplementation or antioxidants containing Se+Vit E (<em>P</em>&gt;0.05). Single-arm studies reported some benefits in motility, morphology, concentration, and DFI. Antioxidant regimens including Se+Vit E reduced seminal reactive oxygen species (ROS) and apoptotic markers. Pregnancy data were limited and inconclusive.</div></div><div><h3>Conclusion</h3><div>Antioxidants containing Se+Vit E may improve sperm motility. Moreover, supplementation with dual Se+Vit E can enhance sperm motility, normal morphology, and vitality. Due to the heterogeneity of studies, further large and high-quality trials with standardized protocols and critical endpoints like pregnancy rates are required.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"66 ","pages":"Article 100632"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-erythrocyte creatine, plasma creatine and long-term outcomes in stable kidney transplant recipients: Results from the TransplantLines Biobank and Cohort study","authors":"Caecilia S.E. Doorenbos ,&nbsp;Adrian Post ,&nbsp;Yvonne van der Veen ,&nbsp;Casper F.M. Franssen ,&nbsp;Michele F. Eisenga ,&nbsp;Robin P.F. Dullaart ,&nbsp;Gerjan Navis ,&nbsp;Qinglin Wu ,&nbsp;Jessica M. Gonzalez-Delgado ,&nbsp;Margery A. Connelly ,&nbsp;Stephan J.L. Bakker","doi":"10.1016/j.nutos.2025.11.013","DOIUrl":"10.1016/j.nutos.2025.11.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Kidney transplant recipients (KTR) have excess mortality compared to the general population and show altered creatine homeostasis. Creatine, an endogenous nitrogenous compound, is essential for energy metabolism. We investigated determinants of circulating creatine and their sex-specific associations with mortality in KTR.</div></div><div><h3>Methods</h3><div>Intra-erythrocyte and plasma creatine were quantified by nuclear magnetic resonance in samples from KTR and living kidney donors (healthy controls) from the TransplantLines Biobank and Cohort study (ClinicalTrials.gov: NCT03272841). Determinants of intra-erythrocyte and plasma creatine were assessed using linear regression; associations with mortality were evaluated with Cox regression.</div></div><div><h3>Results</h3><div>815 KTR and 53 healthy controls were included. Compared with controls, KTR had higher intra-erythrocyte but lower plasma creatine, with women having higher concentrations of each in both groups. In KTR, plasma creatine, BMI, erythrocyte count, reticulocyte count, lactate dehydrogenase, and erythropoietin use were positively associated with intra-erythrocyte creatine, whereas hemoglobin, haptoglobin, ferritin, transferrin saturation, proliferation inhibitor use were negatively associated. In univariable analyses, higher intra-erythrocyte creatine was associated with higher risk of mortality in male KTR (HR: 2.30 (1.50; 3.54), <em>P</em>&lt;0.001), with a weaker, nonsignificant trend in female KTR (HR: 1.51 (0.76; 3.02), <em>P</em>=0.23). Furthermore, higher plasma creatine was associated with higher risk of mortality in male KTR (HR: 1.36 (1.07; 1.73), <em>P</em>=0.01), but not in female KTR (HR: 0.94 (0.68; 1.28), <em>P</em>=0.68). These associations persisted after adjustment for potential confounders.</div></div><div><h3>Conclusion</h3><div>KTR have increased intra-erythrocyte and decreased plasma creatine compared with healthy controls. Intra-erythrocyte creatine was linked to markers of erythrocyte turnover, suggesting potential mechanisms. Elevated intra-erythrocyte and plasma creatine were associated with higher mortality in male, but not female, KTR. These findings highlight the need to further explore sex-specific mechanisms underlying creatine metabolism and clinical outcomes in KTR.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100606"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric nutritional risk index predicted survival time in multiple myeloma","authors":"Kazuhito Suzuki ,&nbsp;Tadahiro Gunji ,&nbsp;Riku Nagao ,&nbsp;Masaharu Kawashima ,&nbsp;Hideki Uryu ,&nbsp;Mamiko Momoki ,&nbsp;Hiroto Ishii ,&nbsp;Ryoko Fukushima ,&nbsp;Mitsuji Katori ,&nbsp;Hiroki Yokoyama ,&nbsp;Atsushi Katsube ,&nbsp;Takeshi Saito ,&nbsp;Kaichi Nishiwaki ,&nbsp;Shingo Yano","doi":"10.1016/j.nutos.2025.12.003","DOIUrl":"10.1016/j.nutos.2025.12.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Geriatric nutritional risk index (GNRI), an indicator of nutritional status, has been shown to predict overall survival (OS) in patients with hematological malignancies. However, GNRI has never been investigated in myeloma patients. This retrospective study aimed to investigate the clinical significance of GNRI in myeloma patients.</div></div><div><h3>Materials and Methods</h3><div>We reviewed the medical records of patients with newly diagnosed multiple myeloma, who had received proteasome inhibitor and/or immunomodulatory drug as initial chemotherapy from 2009 to 2022, with follow-up until December 2023. GNRI is calculated as [(14.89 × serum albumin level) + (41.7 × current body weight/ideal body weight)]. Based on previous reports, the GNRI cut-off for high-risk patients is 92.</div></div><div><h3>Results</h3><div>Three hundred and fifty-seven patients were included in this study. The median age was 71 years. The median and mean values of GNRI were 93.2 and 92.4 (±13.8), respectively. Using receiver operator characteristics (ROC) curves, a cutoff of 91.4 yielded the highest area under the curve (AUC). The proportion of patients classified as high GNRI risk was 46.8 %. In a median followed-up time of 37.8 months, OS in the high GNRI risk group was significantly shorter than that in the low GNRI risk group (3 year-OS: 66.7 % and 83.1 %; <em>P</em> &gt; 0.001). In multivariate analysis, high GNRI risk was independently associated with poorer OS (HR 1.716, <em>P</em> = 0.016), whereas PS and simplified frailty score were not. The GNRI risk was improved during treatment overtime; the frequencies of GNRI risk at 3, 6, and 12 months after treatment was initiated was 40.0 %, 32.3 %, and 29.9 %, respectively. The GNRI risk assessed at 12 months predicted subsequent OS more accurately than the baseline GNRI, as demonstrated by ROC analysis (AUC, 0.690 <em>vs</em>. 0.582; <em>P</em> = 0.009). Patients whose GNRI improved from high risk at diagnosis to low risk at 12 months had OS comparable with those with low risk at diagnosis, suggesting that improved GNRI risk predicted good prognosis.</div></div><div><h3>Conclusion</h3><div>High GNRI risk at diagnosis predicted short OS in myeloma patients. The GNRI risk changed overtime during treatment, and a dynamic GNRI model predicted OS in myeloma patients.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100609"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145814421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linguistic and content validation of the patient-generated subjective global assessment (PG-SGA) in Indonesian for use by cancer patients and healthcare professionals","authors":"Annela Manurung ,&nbsp;Marcellus Simadibrata ,&nbsp;Andri Sanityoso S ,&nbsp;Ikhwan Rinaldi ,&nbsp;Faith D. Ottery","doi":"10.1016/j.nutos.2025.12.013","DOIUrl":"10.1016/j.nutos.2025.12.013","url":null,"abstract":"<div><h3>Background</h3><div>Assessment of malnutrition is important in cancer patients, especially in gastrointestinal cancer in Indonesia. The Scored Patient-Generated Subjective Global Assessment (PG-SGA), an instrument that allows interdisciplinary assessment of malnutrition and its risk factors, has yet to be available in the Indonesian version.</div></div><div><h3>Object</h3><div>To produce a valid and reliable PG-SGA questionnaire in Indonesian while maintaining the English version’s form, purpose, and meaning.</div></div><div><h3>Methods</h3><div>The PG-SGA questionnaire was translated, culturally and linguistically adapted, following the International Society for Pharmacoeconomics (ISPOR) principles. Each question item in the questionnaire will be assessed based on content validity, comprehensibility, and difficulty, operationalized by calculating item and scale indices. A scaled score of 0.80–0.90 is considered acceptable, while a score of more than 0.90 is considered excellent.</div></div><div><h3>Results</h3><div>The content validity of the entire PG-SGA questionnaire obtained an S-CVI of 0.92. The content validity score of the PG-SGA questionnaire on professional participants was S-CVI 0.91. The comprehensibility score of professional and general public participants was S–CI 0.89. The score for the difficulty of question items on the PG-SGA questionnaire with professional and general public participants obtained the results of S-DI 0.86 and 0.88.</div></div><div><h3>Conclusion</h3><div>The translation and cultural adaptation of the PG-SGA questionnaire according to the ISPOR principles of successfully maintaining the format, purpose, and meaning of the Indonesian version of the PG-SGA questionnaire. The PG-SGA questionnaire’s Indonesian version is now comprehensible and relevant for patients, the general public, and professionals. However, there are components of the professional questions that are considered difficult, so additional descriptions or brief explanations and training are needed, especially for physical examinations.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100619"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145940055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Double burden of malnutrition in women of reproductive age in Morocco: A household-based survey","authors":"Fall Abdourahmane ,&nbsp;Lazrak Meryem ,&nbsp;El Ammari Laila ,&nbsp;Benjeddou Kaoutar ,&nbsp;Gamih Hasnae ,&nbsp;Yahyane Abdelhakim ,&nbsp;Baha Rabi ,&nbsp;Benjouad Abdelaziz ,&nbsp;Heikel Jaafar ,&nbsp;Barkat Amina ,&nbsp;Aguenaou Hassan ,&nbsp;El Kari Khalid ,&nbsp;El Hsaini Houda","doi":"10.1016/j.nutos.2025.12.002","DOIUrl":"10.1016/j.nutos.2025.12.002","url":null,"abstract":"<div><h3>Introduction</h3><div>The double burden of malnutrition (DBM) is a major challenge for developing countries. In Morocco, overall understanding of this phenomenon remains limited. National data indicate that women of reproductive age (WRA) are particularly affected: 61.3 % are overweight/obese, 34.4 % are anemic, 30.3 % suffer from iron deficiency (ID) and 49.7 % iron deficiency anemia (IDA).</div></div><div><h3>Objective</h3><div>The current study was conducted to determine the prevalence of DBM in Morocco, defined as coexistence of iron deficiency and overweight/obesity among women of reproductive age.</div></div><div><h3>Methods</h3><div>We conducted a nationally representative cross-sectional survey with a total of 2090 WRA focusing on both iron status and overweight/obesity. Data collection included blood sampling, socio-economic and anthropometric parameters. Biological analyses measured hemoglobin, ferritin and C-reactive protein (CRP).</div></div><div><h3>Results</h3><div>The results obtained revealed that 60.2 % of WRA were overweight/obese, with 30.7% having ID, 34.5% having anaemia and 50.0% having IDA. Overweight/obesity was associated with anemia in 19.4% of 2086 WRA (p &lt; 0.05), 30.7% classified as mild, 23.7% as moderate and 2.0% as severe (p &gt; 0.05). In addition, 17% of participants were diagnosed with iron deficiency, whereas iron deficiency anaemia was detected in 29.9% of participants. <u>(</u>With ID in 17.0% of 1987 WRA) (p &lt; 0.05) and with IDA in 29.9% of 1983 WRA (p &lt; 0.05). on the other hand, 32.3% of the 1254 overweight/obese WRA had anaemia, which was classified as mild in 54.5%, moderate in 42.0%, and severe in 3.5%. Iron deficiency was detected in 28.4% of 1189 WRA and iron deficiency anaemia in 54.3% of 1185 (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>DBM among WRA highlights emerging reality of interconnected and simultaneous coexistence of undernutrition and overnutrition at individual level. This phenomenon, observed on a global scale and affecting millions of individuals, has significant implications for households and population.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100608"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145814423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cachexia, sarcopenia, malnutrition and their impact on survival, treatment toxicities, and quality of life in locally advanced cervical cancer patients undergoing concomitant chemoradiotherapy: A scoping review","authors":"Canio Martinelli ,&nbsp;Alfredo Ercoli ,&nbsp;Luigi Alfano ,&nbsp;Francesca Pentimalli ,&nbsp;Giulio Mazzarotti ,&nbsp;Giacomo Ferrantelli ,&nbsp;Antonino De Lorenzo ,&nbsp;Teresa Esposito ,&nbsp;Antonio Giordano ,&nbsp;Salvatore Cortellino","doi":"10.1016/j.nutos.2025.100620","DOIUrl":"10.1016/j.nutos.2025.100620","url":null,"abstract":"<div><h3>Background</h3><div>Concurrent chemoradiotherapy for locally advanced cervical cancer (LACC) must be completed within 56 days, with each added day increasing recurrence risk by 1%. Sarcopenia, malnutrition, and cachexia affect 20–60% of patients, yet guidelines do not recommend routine screening, and their independent associations with outcomes remain unmapped.</div></div><div><h3>Methods</h3><div>We searched MEDLINE, Scopus, Web of Science, and Cochrane (1995–2025) for studies reporting cachexia, malnutrition, or sarcopenia with survival, toxicity, treatment completion, or quality of life in LACC patients receiving chemoradiotherapy. Two reviewers screened records, extracted data, and assessed bias using QUIPS.</div></div><div><h3>Results</h3><div>Twenty-three studies (4,352 women; cohorts 41–391) used heterogeneous definitions. Malnutrition was assessed in 17 studies, sarcopenia in 15, and cachexia in 2. Malnutrition showed 1.5- to 3.7-fold higher mortality. Chemotherapy-defined sarcopenia predicted survival in 5 of 11 assessments (HR 1.75–3.60); sarcopenic obesity carried HR 2.65. On-treatment body-composition loss showed strongest effects: ≥7–10% skeletal-muscle decline (HR 6.02) and ≥15% intermuscular fat loss (HR 8.52) predicted higher mortality. Grade ≥3 toxicity and treatment interruption were 1.2- to 2.5-fold more frequent in malnourished or sarcopenic women, increasing to 3–5-fold with multiple unfavorable body-composition features. Quality-of-life scores declined 11% during treatment. Seventeen studies had high bias risk from attrition and inadequate confounder control.</div></div><div><h3>Conclusions</h3><div>Malnutrition, sarcopenia, and cachexia correlate with poor survival and treatment tolerance in LACC chemoradiotherapy; on-treatment muscle loss shows strongest prognostic value. Screening at baseline and muscle quantification on chemotherapy can identify high-risk patients. Consensus definitions, prospective validation, and multimodal prehabilitation trials are needed before implementation.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100620"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145940054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}