Clinical Nutrition Open Science最新文献

{"title":"The effect of vitamin D and vitamin A supplementation on T cell levels of patients with pneumosepsis: A double-blind, randomized clinical trial","authors":"Abolfazl Jokar ,&nbsp;Alireza Sistani ,&nbsp;Ghasem Mosayebi ,&nbsp;Atefeh Poyandeh","doi":"10.1016/j.nutos.2024.12.003","DOIUrl":"10.1016/j.nutos.2024.12.003","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Pneumosepsis is a global healthcare challenge associated with substantial morbidity and mortality rates. Its pathogenesis involves intricate interactions among host factors, pathogens, and immune dysregulation. Vitamins A and D are crucial for immune function, acting as regulators and cofactors in immune cell development and function. Given these roles, this study aimed to assess the impact of combined vitamin D and A supplementation on T cell levels in pneumosepsis patients.</div></div><div><h3>Methods</h3><div>This double-blind clinical trial enrolled 84 pneumosepsis patients who were randomly assigned to four groups after demographic data collection. Intervention: Group 1 received standard treatment plus 300,000 IU of vitamin D and 50,000 IU of vitamin A. Group 2 received standard treatment plus 300,000 IU of vitamin D. Group 3 received standard treatment plus 50,000 IU of vitamin A. Group 4 received only standard treatment. Main outcome measures: Vital signs were monitored every 6 hours, and T-cell count, ESR, CRP, creatinine, urea, and uric acid levels were assessed at 0, 24, 48, and 72 hours.</div></div><div><h3>Results</h3><div>Initially and one day post-intervention, vital signs and blood factors showed no significant differences among the groups. However, on days two and three post-intervention, the combined vitamin D and A group exhibited significantly lower levels compared to other groups. Lymphocytes expressing CD3+, CD4+, CD25+, CD3,4+, and CD3,4,25+ markers significantly differed in the combined vitamin A + D group versus the control. No significant differences were noted in lymphocyte percentages between the combined vitamin A + D group and those receiving only vitamin D or A.</div></div><div><h3>Conclusion</h3><div>This study underscores the potential benefits of concurrent vitamin D and A supplementation in reducing symptoms among pneumosepsis patients, particularly in modulating key physiological parameters and immune responses.</div></div><div><h3>Trial registration</h3><div>This study is registered on Iranian Registry of Clinical Trials (IRCT) under identifieron IRCT20130424013110N10. (The registration date: Jul 6, 2020).</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 122-133"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence and human microbiome: A brief narrative review","authors":"Danielle Cristina Fonseca ,&nbsp;Gabriel da Rocha Fernandes ,&nbsp;Dan Linetzky Waitzberg","doi":"10.1016/j.nutos.2024.12.009","DOIUrl":"10.1016/j.nutos.2024.12.009","url":null,"abstract":"<div><div>The human microbiome is a complex ecosystem that influences various functions within the human body. With technological advancements, microbiome studies have expanded, bringing forth the challenge of interpreting large volumes of data, which require robust tools based on artificial intelligence (AI). Subfields of AI, including machine learning (ML) and deep learning (DL), have been applied to analyze complex and large-scale datasets, such as microbiome data, with particular utility in identifying and predicting microorganisms in different health conditions.</div><div>In the era of Big Data, integrating AI with sequencing techniques allows for a more detailed analysis of microbial data, enabling the detection of complex patterns and prediction of health states. However, AI use in this field still faces challenges, such as data heterogeneity (e.g., different sequencing platforms produce data with varying quality and resolution) and the need for data collection and analysis standardization processes (e.g., lack of standardized protocols for sample collection and data analysis).</div><div>Despite these challenges, AI has significant potential to revolutionize microbiome research. It can assist in identifying biomarkers for diagnostics and treatments, advancing personalized nutrition and precision medicine. The future of this field will depend on the continued development of technologies and collaboration among multidisciplinary teams.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 134-142"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet management of older subjects with Oropharyngeal Dysphagia: The efficacy of ready-made texture-modified and fortified meals","authors":"Nikolina Jukic Peladic ,&nbsp;Paolo Orlandoni ,&nbsp;Laura Bartoloni ,&nbsp;Giulia Giulioni ,&nbsp;Claudia Venturini ,&nbsp;Alessia Fumagalli","doi":"10.1016/j.nutos.2024.12.008","DOIUrl":"10.1016/j.nutos.2024.12.008","url":null,"abstract":"<div><h3>Background</h3><div>In-home prepared texture-modified diets are not efficient in preventing the consequences of Oropharyngeal Dysphagia (OD); malnutrition and aspiration pneumonia. Difficulties with their preparation and administration aggravate also the burden of caregivers. This study investigated whether the ready-made texture-modified meals, fortified with amino acids and Vitamin D, may guarantee safe and efficient management of meals in older subjects with OD and facilitate patient management.</div></div><div><h3>Methods</h3><div>Patients who were assessed for dysphagia and nutritional status at the Clinical Nutrition Unit of Ancona and the <em>Pneumology Unit</em> of Casatenovo (LC) of the National Institute of Health and Science on Aging (IRCCS) INRCA and diagnosed with level 4 severity of OD according to IDDSI framework, were invited to use at lunch, for seven consecutive days, the ready-made fortified meals. Face-to-face and phone interviews were used to collect the socio-demographic data and testimonies of 30 out-hospital patients with OD and their formal and informal caregivers in order to assess the safety and liking of products. Simple descriptive statistics were used to summarize the results of the interviews.</div></div><div><h3>Results</h3><div>Out of 493 tastings, only 20 (4%) were interrupted because of an minor adverse event. Ready-made meals, and sweet desserts in particular, were appreciated by subjects with OD; 95% of dishes were consumed entirely, thus ensuring the satisfaction of the protein-calorie needs of patients. Ready-made products positively affected caregiving (75%), especially because the food administration was less time-consuming (90%).</div></div><div><h3>Conclusions</h3><div>Ready-made texture-modified fortified food seem promising in ensuring the improvement in patients' safety and easing the caregivers' tasks. The specific needs of patients with OD relative to diet consistency and protein-calorie needs should be defined by healthcare staff while the meeting between the needs of patients and the offer of ready-made products should be mediated by the mandatory use of a universal scale for the definition of diet texture.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 98-110"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of pulsative flushing on Candida albicans growth inside three-way stopcocks","authors":"Sachiko Omotani,&nbsp;Misaki Umemura,&nbsp;Marie Miki,&nbsp;Yota Taniguchi,&nbsp;Sadahito Masui,&nbsp;Shino Niki,&nbsp;Yasutoshi Hatsuda,&nbsp;Michiaki Myotoku","doi":"10.1016/j.nutos.2024.12.001","DOIUrl":"10.1016/j.nutos.2024.12.001","url":null,"abstract":"<div><h3>Background &amp; Aim</h3><div><em>Candida albicans</em> (<em>C. albicans</em>) is a common causative pathogen of catheter-related bloodstream infections, resulting in difficult-to-treat candidiasis. Moreover, fluid infusion by total parenteral nutrition (TPN) is commonly combined with lipid emulsion administration from a side tube. We evaluated the growth of <em>C. albicans</em> in closed three-way stopcocks used for simultaneous administration of TPN infusions and lipid emulsions. In addition, the effect of flushing on <em>C. albicans</em> growth was examined.</div></div><div><h3>Methods</h3><div>A TPN infusion solution and a lipid emulsion were tested using two different closed-type three-way stopcocks. The strain used was <em>C</em>. <em>albicans</em> IFM 61197. Simultaneous administration of the TPN infusion solution (2,000 mL over 24 h) and the lipid emulsion with <em>C. albicans</em> (100 mL over 4 h) were simultaneously administered using the piggyback method and an infusion pump. Flushing with physiological saline was performed via the side tube of the three-way stopcock after lipid emulsion administration. The flushing volumes were 0, 5, 10, and 20 mL. Continuous flushing (CF) and pulsative flushing (PF) were used as flushing methods. The infusion fluid remaining in the three-way stopcock was sampled immediately before completing lipid emulsion administration and 24 h after beginning administration of the TPN infusion solution. From these samples, colony-forming unit (CFU) counts were determined. In addition, after the last sampling at 24 h, the stopcock interior was washed with phosphate-buffered saline, and CFU counts determined.</div></div><div><h3>Results</h3><div>Without flushing, <em>C. albicans</em> grew in the two types of three-way stopcocks. When flushing with saline after lipid emulsion administration was performed, growth of <em>C. albicans</em> was lower than without flushing. Increasing flushing volume and using PF as the flushing method were found to decrease <em>C. albicans</em> growth in the three-way stopcocks.</div></div><div><h3>Conclusion</h3><div>As <em>C. albicans</em> growth was reduced inside the three-way stopcock by flushing after lipid emulsion administration, PF was demonstrated as effective against <em>C. albicans</em> growth within the three-way stopcocks. However, experimental results varied substantially, despite using the same experimental procedures. Therefore, proper flushing requires an appropriate level of skill and training to appropriate infusion solution management and operation to prevent microbial contamination.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 45-55"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition defined by Global Leadership Initiative on Malnutrition criteria, cachexia, and dietary intake among adult patients with cancer undergoing chemotherapy","authors":"Chipiliro Dannayo ,&nbsp;Aaron Thokozani Chikakuda ,&nbsp;Richard Nyasosela ,&nbsp;Getrude Mphwanthe","doi":"10.1016/j.nutos.2024.11.005","DOIUrl":"10.1016/j.nutos.2024.11.005","url":null,"abstract":"<div><h3>Background and aims</h3><div>Malnutrition is associated with high morbidity and mortality among patients with cancer. In Malawi, there is limited data on the prevalence of malnutrition and cachexia and associated factors among adult out-patients with cancer. We therefore assessed factors associated with malnutrition, cachexia, and dietary intake in adult outpatients with cancer undergoing chemotherapy.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted at the National Cancer Centre in Malawi, targeting adult outpatients with different types of cancer. Data collected included socio-demographic characteristics, anthropometrics, health-related information, inflammatory biomarkers, and dietary intakes. We screened for malnutrition risk using the Malnutrition Screening Tool and assessed for malnutrition and cachexia using the Global Leadership Initiative on Malnutrition and Fearon criteria, respectively. Multivariate logistic and linear regressions examined the factors associated with malnutrition, cachexia, and dietary intake at p&lt;0.05, using SPSS.</div></div><div><h3>Results</h3><div>Our study included 97 patients with a mean age of 49.24 ± 13.9 years, and 68.0% were female. The common types of cancer were cervical (47.4%) and gastrointestinal (20.6%). Approximately 51.5% of the patients were at risk of malnutrition, 33.0% were malnourished, and 24.7% had cachexia. The estimated median [Interquartile range: IQR] protein (0.99 g/kg/day [0.76; 1.42]; p=0.028) and dietary fiber (19.40 g/day [12.85; 29.50]) intakes were lower than the recommendations. The risk of malnutrition increased with anorexia (p=0.011) and reduced with normal handgrip strength (p=0.037). Gastrointestinal cancer (p=0.016) and high C-reactive protein (p=0.002) were associated with malnutrition. Having gastrointestinal cancer (p=0.040), living with HIV (p=0.030), anorexia (p=0.029), and inadequate energy intake (p=0.012) were associated with cachexia. Furthermore, gastrointestinal cancer was negatively associated with energy (p&lt;0.0001) and protein (p=0.010) intakes.</div></div><div><h3>Conclusions</h3><div>Malnutrition, cachexia, and inadequate dietary intake are of concern in Malawian patients with cancer. Therefore, tailored dietetic/nutrition interventions are urgently needed in this population.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 31-44"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decrease in phase angle after Roux-en-Y gastric bypass is related to increase of anti-inflammatory status","authors":"Amanda Cristina Araújo Gomes ,&nbsp;Amanda Machado Fiorotti ,&nbsp;Amanda Motta de Bortoli ,&nbsp;Beatriz Bobbio de Brito ,&nbsp;João Arthur Souza Fiorido ,&nbsp;Luciane Bresciani Salaroli ,&nbsp;Andressa Bolsoni Lopes ,&nbsp;Fabiano Kenji Haraguchi","doi":"10.1016/j.nutos.2025.01.002","DOIUrl":"10.1016/j.nutos.2025.01.002","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Phase angle (PhA) has been used as a prognostic indicator in various clinical conditions. However, its relationship with inflammatory state during obesity treatment is less known. This study investigated the relationship between PhA and inflammatory parameters in patients undergoing Roux-en-Y gastric bypass (RYGB).</div></div><div><h3>Methods</h3><div>This is a prospective longitudinal study with patients from the Bariatric and Metabolic Surgery Program of a university hospital. Analyses were conducted pre-RYGB and about two and six months post-RYGB. Assessments included serum levels of alpha-1-acid glycoprotein (AGP), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), adiponectin, and resistin, as well as anthropometric data and body composition. Data were analyzed using the one-way repeated measures ANOVA or Friedman's test, followed by Tukey's post hoc test. Relationship between PhA and biochemical and body parameters were assessed using the Spearman or Pearson correlation coefficient. A significance level of 5% was adopted.</div></div><div><h3>Results</h3><div>Final sample was composed of 23 subjects (87% women), aged 40.6 ± 10.7 years. A significant decrease in PhA values accompanied by an improvement in inflammatory parameters were observed post-RYGB (p&lt;0.05). PhA values was inversely correlated with serum adiponectin concentrations (r= −0.376, p&lt;0.05). In addition, BMI and fat-mass were also significantly correlated with serum adiponectin (r= −0.264 for BMI and r= −0.277 for fat-mass, p&lt;0.05) and TNF-alpha (r= 0.338 for BMI and r= 0.335 for fat-mass, p&lt;0.05), whereas serum resistin was correlated only with fat-mass (r= 0.245, p&lt;0.05).</div></div><div><h3>Conclusions</h3><div>Data suggest that the decrease in PhA values during six months post-RYGB may indicate a concomitant improvement of anti-inflammatory state.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 159-170"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Traffic Light Diet System via food analysis in Android app for adolescent nutrition education: A strategy to reduce sugar, salt, and fat consumption","authors":"Trias Mahmudiono ,&nbsp;Alinda Rahmani ,&nbsp;Nur Alifia Hera ,&nbsp;Erwanda Anugrah Permatasari ,&nbsp;Nadia Syfa Zainurrahmah ,&nbsp;Ni Made Ayu Rachel Rasheeta Nuka ,&nbsp;Theresa Winona Wijaya ,&nbsp;Wanda Nurul Asifah","doi":"10.1016/j.nutos.2024.10.014","DOIUrl":"10.1016/j.nutos.2024.10.014","url":null,"abstract":"<div><h3>Introduction</h3><div>In today's global food consumption trend, high sugar, salt, and fat dominate diets, especially among adolescents who frequently utilize online food ordering systems. Monitoring nutritional intake has thus become increasingly crucial. The Traffic Light Diet application serves as a tool to help track the nutritional content of online food purchases. This study aimed to enhance adolescent knowledge and attitudes towards healthier food choices.</div></div><div><h3>Method</h3><div>Adopting a quasi-experimental research design, the study employed a pre-test and posttest approach for both control and intervention groups. The sample comprised 110 participants from Airlangga University, aged 18–25 years, possessing Android devices capable of downloading the application. Participants were recruited and randomly allocated, with data collected through self-reported questionnaires and analyzed using independent and dependent t-tests through the SPSS application.</div></div><div><h3>Results</h3><div>Significant effects were observed in knowledge levels following nutritional education provision in both groups. However, no significant difference was found in attitudes posteducation. Specifically, the control group showed no significant difference in attitudes, whereas the intervention group did.</div></div><div><h3>Discussion</h3><div>While both groups demonstrated improvements in knowledge and attitude posteducation, the control group exhibited higher scores. Although there was a significant effect between nutrition education and knowledge, the impact on attitudes was insignificant in the control group. This fact maybe due to the differences between participant baseline characteristic such an educational background.</div></div><div><h3>Conclusion</h3><div>These findings suggest the Traffic Light Diet app is useful but has room for improvement to better influence attitudes towards nutrition among participants. Although there was a significant effect between nutrition education and knowledge, the impact on attitudes was insignificant in the control group. This fact maybe due to the differences between participant baseline characteristic such an educational background.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 206-215"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuum of Care - Building bridges between different phases of the patient's pathway","authors":"Michael Adolph ,&nbsp;Marek Lichota","doi":"10.1016/j.nutos.2024.12.007","DOIUrl":"10.1016/j.nutos.2024.12.007","url":null,"abstract":"<div><div>The presented Continuum of Care concept refers to a patient-oriented care system describing a modern nutrition management workflow avoiding malnourished patients. For long time, nutrition has had low priority compared to resuscitation and other immediate therapies but does play an important role as malnutrition is associated with increased complications and delayed postoperative recovery. For optimal clinical outcomes, it is important to immediately start targeted nutritional therapy during severe illness. Continuum of care in a modern nutrition management starts with a diagnosis and the decision for surgery. It is an interdisciplinary approach involving different medical specialists. Ahead of surgical procedures, the patient´s condition is improved in the best possible way by means of a multimodal prehabilitation approach combining different interventions, e.g., exercise, patient education, psychologic support, and nutrition. This approach aims at strengthening the nutritional, physical as well as the psychological status of the patient. Addressing pre-operative risk factors significantly impacts the postoperative period. Patients actively participate in this process and receive supervision both before and during their hospital stay, as well as during discharge and the subsequent recovery and rehabilitation phase. Healthcare professionals should prioritize nutritional requirements. While guidelines on nutritional care exist, translating these guidelines into individualized nutritional plans is essential for providing optimal patient care. Thus, the presented Continuum of Care concept reflects an efficient, adapted nutritional therapy for patients throughout the whole course of their illness to fight malnutrition.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 111-121"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cinnamon treatment shows promise for glycemic control but may cause adverse effects in some people","authors":"Laura del Bosque-Plata ,&nbsp;Claudia Gragnoli","doi":"10.1016/j.nutos.2025.01.003","DOIUrl":"10.1016/j.nutos.2025.01.003","url":null,"abstract":"<div><div>Cinnamon has a long history as a treatment for a range of health conditions, and recent studies have provided evidence for its beneficial effects, particularly for hyperglycemia and type 2 diabetes (T2D). However, cinnamon can contain high amounts of naturally occurring coumarin, a blood thinner. So, its use as a treatment needs to be balanced with its potential anticoagulant effects.</div><div>We hypothesize that cinnamon treatment may pose a risk for some patients, depending on the dose and duration of treatment and individual characteristics, including age, sex, and use of other medications.</div><div>In this short article, we provide an overview and discussion of the published literature, as well as our own experiences in the clinic, which raise potential concerns about the safety of cinnamon treatment. In particular, there are concerns about the dose, especially when used in the context of anticoagulant or antiplatelet therapies.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"59 ","pages":"Pages 184-188"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143095344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superior liver protection in mice fed total parenteral nutrition containing the novel lipid emulsion Vegaven as compared to a mixed-oil lipid emulsion containing fish oil","authors":"Eliana Lucchinetti ,&nbsp;Phing-How Lou ,&nbsp;Alessandro Quaranta ,&nbsp;Craig E. Wheelock ,&nbsp;Akash Chakravarty ,&nbsp;Martin Hersberger ,&nbsp;Stefanie D. Krämer ,&nbsp;Michael Zaugg","doi":"10.1016/j.nutos.2025.01.009","DOIUrl":"10.1016/j.nutos.2025.01.009","url":null,"abstract":"<div><h3>Background</h3><div>Mixed-oil lipid emulsion with plant-based 18-carbon <em>n-3</em> fatty acids (Vegaven) elicits superior liver protection in total parenteral nutrition (TPN) compared with soybean oil-based or fish oil-based lipid emulsions.</div></div><div><h3>Objective</h3><div>However, it is not known whether Vegaven is also superior to mixed-oil lipid emulsions containing longer-chain 20/22-carbon <em>n-3</em> fatty acids derived from fish oil (SMOFlipid).</div></div><div><h3>Methods</h3><div>Instrumented male C57BL/6NCrl mice (N=5) were subjected to a 7-day TPN with Vegaven (VEGA) or SMOFlipid (SMOF). Mice infused with 0.9% saline and free access to water and rodent diet served as controls. Tissue concentration of cytokines, indices of whole-body and hepatic glucose metabolism, markers of liver injury, and hepatic lipid mediators were measured.</div></div><div><h3>Results</h3><div>Whole-body insulin resistance as measured by HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) values was lower in VEGA compared with SMOF and accompanied by higher glucagon and lower insulin plasma levels. The abundances of hepatic insulin receptor (IR), insulin receptor substrate 2 (IRS2) as well as the tyrosine phosphorylated IRS2 were higher in VEGA when compared with SMOF, fostering higher hepatic glycogen content. Tumor necrosis factor alpha and interleukin-6 (IL6) tissue concentrations were increased in livers of mice in the SMOF group and interleukin-6 (IL6) to interleukin-10 (IL10) ratios were lower in livers and epididymal white adipose tissue of mice in the VEGA group. Direct bilirubin plasma levels were elevated in SMOF, while ALT plasma levels were similar in all groups. Profiling of hepatic lipid mediators revealed the presence of α-linolenic acid-derived hydroxy-octadecatrienoic acid species exclusively in VEGA.</div></div><div><h3>Conclusions</h3><div>TPN with Vegaven provides superior liver protection and whole-body blood glucose control than TPN with mixed-oil lipid emulsion containing fish oil in mice.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"60 ","pages":"Pages 22-37"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}