The effects of flaxseed supplementation on metabolic syndrome risk factors; A comprehensive review

Q3 Nursing

Clinical Nutrition Open Science Pub Date : 2025-02-22 DOI:10.1016/j.nutos.2025.02.010

Elyas Nattagh-Eshtivani , Hanieh Barghchi , Alireza Hatami , Mehdi Barati , Ali Heydari , Zohreh Abdi Moghaddam , Mohammad Vahedi Fard , Kimia Mohammadhasani , Hamidreza Miri , Saeedeh Talebi , Naseh Pahlavani

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Abstract

Background

Flax (also called Linum Usitatissimum) is a flowering plant with tiny seeds that are rich in fiber, omega-3 fatty acids, phenolic acids, and phytoestrogens. Recent studies have investigated the health benefits of flaxseed supplementation because of its components and antioxidant capacity. Metabolic syndrome (MetS) is a multi-factorial disorder associated with a wide range of chronic diseases. The present comprehensive review aims to summarize the effect of flaxseed supplementation on MetS.

Results

Flaxseed supplementation has positive effects on different health markers associated with MetS. It was associated with lower body mass index (BMI), visceral fat, and total body fat. Additionally, flaxseed supplementation reduces blood pressure (BP) by improving vasodilation. In terms of lipid profile, it attenuates low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG). Flaxseed supplementation can also improve glycemic indices, such as fasting blood sugar (FBS), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), and Quantitative Insulin Sensitivity Check Index (QUICKI). Furthermore, the antioxidant properties of flaxseeds improve oxidative stress and inflammatory markers, while increasing anti-inflammatory markers.

Conclusion

Flaxseed supplementation may improve MetS by affecting anthropometric indices, BP, lipid profile, glycemic indices, oxidative stress, and inflammatory markers.

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补充亚麻籽对代谢综合征危险因素的影响全面回顾

亚麻（也被称为亚麻）是一种开花植物，其微小的种子富含纤维、omega-3脂肪酸、酚酸和植物雌激素。最近的研究调查了亚麻籽补充剂的健康益处，因为它的成分和抗氧化能力。代谢综合征（MetS）是一种与多种慢性疾病相关的多因素疾病。本文综述了补充亚麻籽对MetS的影响。结果补充亚麻籽对与MetS相关的各种健康指标均有积极影响。它与较低的身体质量指数（BMI）、内脏脂肪和全身脂肪有关。此外，亚麻籽补充剂通过改善血管舒张来降低血压。在脂质方面，它降低了低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）和甘油三酯（TG）。补充亚麻籽还可以改善血糖指标，如空腹血糖（FBS）、胰岛素抵抗稳态模型评估（HOMA-IR）和胰岛素敏感性定量检查指数（QUICKI）。此外，亚麻籽的抗氧化特性改善了氧化应激和炎症标志物，同时增加了抗炎标志物。结论补充亚麻籽可能通过影响人体测量指数、血压、血脂、血糖指数、氧化应激和炎症指标来改善代谢代谢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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