Clinical Nutrition Open Science最新文献

{"title":"The potensial effects of high protein diet on renal function in body builders in Erbil city","authors":"Muhanad Salah Mawlood","doi":"10.1016/j.nutos.2025.11.001","DOIUrl":"10.1016/j.nutos.2025.11.001","url":null,"abstract":"<div><h3>Background</h3><div>The Kidneys are known for their critical role in waste filtration and urine production, an important role of the kidney in the protein metabolism including breakdown and excretion of protein, excessive protein intake can impose significant stress on the kidneys, potentially leading to various complications.</div></div><div><h3>Aim</h3><div>aim of this study is to identify any possible health risks associated with consuming high protein diet.</div></div><div><h3>Persons and methods</h3><div>This study was cross – sectional study comprised (40) healthy participants between the ages of 18 and 48 participated. The participants were classified by two types of classification: according to protein intake per day and by duration of protein intake. (10) people were assigned to the control group, (18) athletes who consumed less than 200 grams of protein per day were assigned to the low-protein diet group, and (12) athletes who consumed more than 200 grams of protein per day were assigned to the high-protein diet group. According to duration of protein intake participants were divided into three groups: seventeen (17) participants less than five years, seven (7) participants between five to ten, and (6) participants more than 10 years of duration.</div></div><div><h3>Result</h3><div>It is clearly demonstrated statistically significant differences in mean of age (<em>p</em> = 0.003), blood urea (<em>p</em> = 0.007), serum creatinine (<em>p</em> &lt; 0.001), Urinary Albumin to Creatinine Ratio (<em>p</em> &lt; 0.001) and Urinary Protein to Creatinine Ratio (<em>p</em> &lt; 0.001) between the control group and the entire athletic (&lt;200 g/day and ≥200 g/day) groups. A highly significant differences between the means of Urinary Albumin to Creatinine Ratio (ACR) and Urinary Protein to Creatinine Ratio (PCR) between the three duration of protein intake (&lt;5, 5–10 and &gt; 10 years) groups (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The findings of this study highlight the importance of moderation in protein intake to maintain optimal renal health. While protein is a vital nutrient, excessive and prolong consumption, particularly in the context of a high-protein diet, may pose risks to kidney function.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 305-312"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between muscle quality index and depression in adults: A cross-sectional study","authors":"Yuanyuan He,&nbsp;Shenshen shi,&nbsp;Zhen liang,&nbsp;Juan Wang","doi":"10.1016/j.nutos.2025.09.004","DOIUrl":"10.1016/j.nutos.2025.09.004","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>The muscle quality index (MQI) score is a new indicator of muscle quality and is closely related to physical health. This study aimed to investigate the association between the MQI score and depression in young and middle-aged people.</div></div><div><h3>Methods</h3><div>Complete MQI and depression data were obtained from the National Health and Nutrition Examination Survey (NHANES) database from 2011-2014 for 5199 subjects aged 20–60 years. An assessment of depression was conducted using the Patient Health Questionnaire (PHQ-9). Appendicular skeletal muscle mass (ASM) and handgrip strength (HGS) were measured via dual-energy X-ray absorptiometry (DXA) and a dynamometer, respectively. MQItotal, MQIapp and MQIarm were calculated by HGS sum/ASM (kg/kg), dominant HGS/ASM (kg/kg), and dominant HGS/dominant arm ASM (kg/kg), respectively. Multivariate regression analyses, subgroup analyses, trend tests, interaction tests, smooth curve fitting, and threshold effect and saturation effect analyses were performed.</div></div><div><h3>Results</h3><div>The mean age of the included population was 38.76 ± 11.57 years, of which 48.5 1% were female. Multivariate regression analyses revealed that the MQI score was negatively correlated with depression. Subgroup analyses revealed that this association was present in females but not in males. After all included confounders were adjusted, the risk of depression in women decreased by 32 %, 35 %, and 6 %, as MQItotal (OR 0.68, 95% CI 0.54–0.84), MQIapp (OR 0.65, 95% CI 0.47–0.91) and MQIarm (OR 0.94, 95% CI 0.90–0.99) increased per unit, respectively. Women in MQItotal, MQIapp, and MQIarm quartile 4 had a significantly lower incidence of depression than did those in quartile 1. In addition, smoothing curve fitting revealed that MQItotal, MQIapp, and MQIarm were not linearly correlated with the risk of depression in women but rather had a J-shaped relationship, with inflection points of 2.24, 1.01 and 8.35, respectively.</div></div><div><h3>Conclusions</h3><div>According to the results of this study, MQI scores negatively correlate with depression in women, but not in men, demonstrating a J-shaped relationship.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 73-83"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional risk and risk of dysphagia in Parkinson's disease: Insights from a rehabilitation setting","authors":"Jonas Anias Svendsen ,&nbsp;Steffen Arild Kronvold ,&nbsp;Malene Sofie Malmstrøm ,&nbsp;Anja Weirsøe Dynesen","doi":"10.1016/j.nutos.2025.08.008","DOIUrl":"10.1016/j.nutos.2025.08.008","url":null,"abstract":"<div><h3>Background and Aim</h3><div>Parkinson's disease (PD) is a progressive neurodegenerative disorder often accompanied by malnutrition and dysphagia, which significantly impact quality of life and clinical outcomes. This study aimed to evaluate the prevalence of nutritional risk, malnutrition, sarcopenia and risk of dysphagia among individuals with PD in a Danish rehabilitation setting. Additionally, it examined the prevalence and impact of nutrition impact symptoms (NIS) on dietary intake.</div></div><div><h3>Methods</h3><div>A cross-sectional pilot study was conducted at the Sano Rehabilitation Centre, Denmark, including 44 participants with PD in phases 2 and 3 of disease progression. Nutritional risk was assessed using the Nutritional Risk Screening 2002 (NRS-2002), and malnutrition was classified according to the Global Leadership Initiative on Malnutrition (GLIM) criteria. Swallowing difficulties were evaluated using the Eating Assessment Tool-10 (EAT-10), and NIS were assessed using a modified questionnaire from the Danish Health Authority. Sarcopenia was identified using handgrip strength, bioimpedance analysis and the Timed Up and Go test.</div></div><div><h3>Results</h3><div>The study found that 23% of the participants were at nutritional risk, with 7% classified with malnutrition. Risk of dysphagia was identified in 34% of the participants, whereas swallowing difficulties (34.1%), constipation (45.5%) and rapid satiety (31.8%) were the most common NIS. Notably, 90% of the participants reported experiencing at least one NIS, and 59% indicated that these symptoms affected their dietary intake. Sarcopenia was confirmed in 2.5% of the participants.</div></div><div><h3>Conclusion</h3><div>This study highlights the prevalence of nutritional risk, risk of dysphagia and NIS among individuals with PD undergoing rehabilitation.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 136-146"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat-inactivated Lactobacillus gasseri CP2305 improves bowel function and gut microbiota – A systematic literature review","authors":"Anna Chu ,&nbsp;Samir Samman ,&nbsp;Nicole C. Roy ,&nbsp;Meika Foster","doi":"10.1016/j.nutos.2025.09.001","DOIUrl":"10.1016/j.nutos.2025.09.001","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>The health benefits of probiotics have long been studied. More recently, postbiotics are recognised as suitable alternatives for delivering associated health benefits. The aim of this systematic literature review is to assess the effects of heat-inactivated <em>Lactobacillus gasseri</em> CP2305 on bowel function and gut microbiota composition in humans.</div></div><div><h3>Methods</h3><div>A literature search was conducted of peer-reviewed papers published up to 20 August 2024. Intervention trials that investigated the effects of heat-inactivated CP2305 on gut-related parameters were selected for inclusion and data extraction. Quality and risk of bias assessments of individual studies were conducted using two established tools.</div></div><div><h3>Results</h3><div>Seven trials met the inclusion criteria. CP2305 intervention resulted in improved stool properties (output, form, color, odor) in the four studies reporting these outcomes. CP2305 effects on defecation frequency were mixed; however, defecation frequency was improved in populations with constipation tendencies. CP2305 was associated with some positive changes in gut microbiota composition and associated metabolites in studies which included these outcomes.</div></div><div><h3>Conclusion</h3><div>The current systematic review illustrates that heat-inactivated CP2305 can improve bowel function and gut microbiota diversity and composition in generally healthy adults, supporting its use in food and beverage applications for maintenance of a healthy gut.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 25-38"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted literature review and assessment of evidence in microvillus inclusion disease (MVID)","authors":"Antonella Diamanti ,&nbsp;Merit Monique Tabbers ,&nbsp;Christos Tzivinikos ,&nbsp;Mohammad Saleh Miqdady ,&nbsp;Antonino Morabito ,&nbsp;Michela Pantaleoni ,&nbsp;Pravin Chaturvedi ,&nbsp;Andrea Mantovani ,&nbsp;Rithvik Badinedi ,&nbsp;Cecile Lambe","doi":"10.1016/j.nutos.2025.10.007","DOIUrl":"10.1016/j.nutos.2025.10.007","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Microvillous inclusion disease (MVID) is a rare, severe congenital disorder characterized by intractable diarrhea and life-threatening complications, including dehydration, malnutrition, intestinal failure, and eventually death. This review aims to synthesize reported evidence on MVID's clinical manifestations, treatment, and outcomes, highlighting the disease burden and identifying key gaps in current knowledge.</div></div><div><h3>Methods</h3><div>A literature review was conducted on 83 publications, including case reports and cohort studies. Studies were selected based on clinical or epidemiological data on MVID, focusing on diagnostics, treatment, and patient outcomes.</div></div><div><h3>Results</h3><div>MVID typically presents in neonates with severe diarrhea that rapidly leads to dehydration and 523 malnutrition. MVID is associated with frequent complications and high mortality (30%) reflecting the disease's severity and limitations of current treatments. Most patients remain lifelong dependent on total parenteral nutrition (TPN), increasing risks and burden. The review also revealed a lack of consistent epidemiological data and variability in clinical management.</div></div><div><h3>Discussion</h3><div>Findings underscore the need for standardized diagnostic protocols and treatment strategies. Scarcity of evidence and heterogeneity in management highlight the necessity of more comprehensive studies to improve patient outcomes.</div></div><div><h3>Conclusion</h3><div>Addressing these gaps could optimize care and reduce MVID-associated complications. Future research should focus on robust clinical guidelines and long-term data collection to improve treatment outcomes and survival rates.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 278-304"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of school meals to folate and associated nutrients intake among in-school adolescent girls in Sidama Region, Southern Ethiopia","authors":"Amelo Bolka ,&nbsp;Tafese Bosha ,&nbsp;Samson Gebremedhin","doi":"10.1016/j.nutos.2025.10.004","DOIUrl":"10.1016/j.nutos.2025.10.004","url":null,"abstract":"<div><h3>Background</h3><div>In Ethiopia limited evidence exist regarding the prevalence of inadequate dietary folate intake among adolescent girls and how the school feeding program contributes towards folate intake.</div></div><div><h3>Objective</h3><div>This study assessed contribution of school meals to folate and associated nutrients intake among in-school adolescent girls in Sidama region, Southern Ethiopia.</div></div><div><h3>Methods</h3><div>School based cross-sectional study was conducted among 700 adolescent girls. Multistage sampling method was followed to select the study participants. Multiple pass 24-hour dietary recall method was used to assess the dietary intake. Nutrient inadequacy was defined as a dietary intake below the Estimated Average Requirement (EAR). The contribution of school meals to daily nutrient intake was assessed by calculating their percentage of the Recommended Daily Allowance (RDA) for each nutrient, with an ideal target of providing two-thirds of the enrolled group's daily requirements.</div></div><div><h3>Results</h3><div>About one-fourth, 25.2% (95% CI: 21.9%, 28.4%), of the girls had inadequate folate intake. School meals contributed only 35.3% of the folate RDA for adolescent girls and 33.9% of the actual folate intake. School meals also contributed 47.3% of the iron RDA, 10% of zinc, 9.0% of vitamin C, 8.2% of vitamin A, 5.6% of calcium, and 3.7% of vitamin B-12. High prevalence of inadequacies were noted for vitamin B12 (76.7%), vitamin A (75.8%), vitamin C (66.7%), zinc (60.9%), calcium (54.7%), and iron (19%).</div></div><div><h3>Conclusion</h3><div>School meals didn't meet folate RDA. A quarter of the adolescent girls had inadequate dietary folate intake<strong>.</strong> High prevalence of dietary intake inadequacies were also found among adolescent girls. We strongly recommend revising the school meal menu and providing comprehensive nutrition education for girls and parents.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 181-191"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of physical activity and nutrition interventions on glycated haemoglobin (HbA1c) in adolescents with type 1 diabetes mellitus: A systematic review with meta-analysis","authors":"Ruth Martin ,&nbsp;Aine Cronin ,&nbsp;Alexandra Cremona","doi":"10.1016/j.nutos.2025.08.005","DOIUrl":"10.1016/j.nutos.2025.08.005","url":null,"abstract":"<div><h3>Aims</h3><div>This review investigates the effectiveness of physical activity and nutrition interventions on glycated haemoglobin (HbA1c) in adolescents with Type 1 Diabetes Mellitus (T1D).</div></div><div><h3>Methods</h3><div>This review was conducted in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Databases (PsycInfo, Medline, CINAHL complete, Embase, Cochrane Library) and trial registries were searched from 2008. Inclusion criteria included adolescents aged between 10 and 19 years with a diagnosis of T1D, interventional studies involving physical activity and/or nutrition intervention, and HbA1c included as an outcome measure. Information about the studies, participants and outcome measures were extracted from the included studies. The risk-of-bias was performed using Cochrane risk-of-bias 2 tool (ROB-2) and risk-of-bias non-randomized intervention studies (ROBINS-I) tool. The certainty of evidence was assessed using ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) guidance. A meta-analysis was carried out to evaluate the effectiveness of these interventions on HbA1c.</div></div><div><h3>Results</h3><div>The twelve eligible randomised controlled trials included 680 participants in total (of which 658 were diagnosed with T1D). HbA1c for adolescents with T1D at baseline was between 6.9-11%. There was no statistically significant evidence of effect noted for physical activity interventions (6 studies, 362 participants, mean difference -0.40, 95% confidence interval -0.88, 0.08; P = 0.11) or nutrition interventions (5 studies, 224 participants, mean difference -0.05, 95% confidence interval -0.31, 0.21; P = 0.71). Moderate heterogeneity was reported for physical activity (Chi² 10.48, P = 0.06), I²=52%) and nutrition interventions (Chi² 15.59, P = 0.004, I²=74%). There was a high risk of bias for two studies and ‘some concerns’ for six studies.</div></div><div><h3>Conclusions</h3><div>While no statistically significant pooled effects on HbA1c were observed for physical activity or nutrition interventions, most confidence intervals trended toward lower HbA1c, suggesting potential for clinically meaningful benefit. Combined interventions showed signals of HbA1c reduction in small studies, but evidence remains limited and heterogeneous. Overall certainty was low, highlighting the need for robust trials of structured, combined interventions in adolescents.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"63 ","pages":"Pages 238-276"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-restricted periodic fasting: A revolutionary approach to combat obesity by enhancing Bcl-2 pro-survival proteins","authors":"Nurma Yuliyanasari ,&nbsp;Hayuris Kinandita Setiawan ,&nbsp;Adi Pranoto ,&nbsp;Nabilah Izzatunnisa ,&nbsp;Eva Nabiha Zamri ,&nbsp;Muhammad Miftahussurur ,&nbsp;Purwo Sri Rejeki","doi":"10.1016/j.nutos.2025.08.006","DOIUrl":"10.1016/j.nutos.2025.08.006","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Obesity is a global health issue related to many physiological functions such as apoptosis and requires specific treatment approaches, especially in nutrition or diet modification. Our study aims to investigate the effects of time-restricted periodic fasting (TRPF) on the obesity phenotype and Bcl-2 pro-survival proteins in overweight or obese adults.</div></div><div><h3>Methods</h3><div>A quasi-experimental study was conducted in 38 young adult men with obesity and overweight. Participants were separated into a control group (CG) and a time-restricted periodic fasting group (PFG). Anthropometric and body composition measurements measured obesity phenotype, whereas B cell lymphoma 2 (Bcl-2) levels were measured by enzyme-linked immunosorbent assay (ELISA) test.</div></div><div><h3>Results</h3><div>A 10-day TRPF intervention could significantly reduce obesity phenotypes such as body weight (BW) (<em>P</em> = 0.00), body mass index (BMI) (<em>P</em> = 0.00), waist circumference (WC) (<em>P</em> = 0.00), waist-to-height ratio (WtHR) (<em>P</em> = 0.01), visceral fat level (VFL) (<em>P</em> = 0.01) and significantly reduced Bcl-2 levels (4.73 ± 4.96 ng/mL) compared to the pretest (5.49 ± 5.94 ng/m; <em>P</em> &lt; 0.05). There was a significant negative correlation between Δ in Bcl-2 levels with certain obesity phenotypes such as waist hip ratio (WHR) (β = -0.35; <em>P</em> &lt; 0.05), BMI (β = -0.35; <em>P</em> &lt; 0.05), body fat (BF) (β = -0.33; <em>P</em> &lt; 0.05), and visceral fat level (VFL) (β = -0.34; <em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>TRPF could reduce some parameters of obesity phenotype. These effects might be related to increased levels of Bcl-2, an anti-apoptotic parameter in young and overweight/obese adult men.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"63 ","pages":"Pages 304-314"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting energy expenditure in patients with COPD: Agreement between predicted equations and indirect calorimetry","authors":"Santi Silairatana ,&nbsp;Sirakarn Tejavanija","doi":"10.1016/j.nutos.2025.08.001","DOIUrl":"10.1016/j.nutos.2025.08.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Accurate, individualized energy and protein, as well as other nutrient components, are highly important to improve the nutritional status and increase muscle mass in COPD patients, particularly those having nutritional depletion and experiencing a loss of lean body mass. Despite having a high degree of accuracy, the determination of energy requirement using indirect calorimetry (IC) is often limited by its availability and therefore predictive equations are used as alternatives. This study aims to determine agreements between measured REE using IC and estimated REE obtained from predictive equations that are commonly used in clinical practice among COPD patients, both with and without malnutrition or sarcopenia.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A cross-sectional study was conducted among clinically- and spirometry-confirmed COPD patients from August 2022 to January 2023. IC, bioelectrical impedance analysis, anthropometry, handgrip strength measurement as well as biochemical tests (serum albumin, ESR and CRP) were performed in all participants to collect data for analysis of correlation and agreement between two methods. The predictive equations tested included the Harris-Benedict, Schofield, Institute of Medicine, Mifflin St Jeor, Westerterp, Morikawa, and Moore &amp; Angelilo equations. The differences of energy expenditure between groups with and without malnutrition or sarcopenia were tested statistically using an independent-sample t-test and Mann-Whitney U test, while correlations, as well as degree of agreement between methods were analyzed and reported using Bland-Altman plots. The significant two-tailed &lt;em&gt;P&lt;/em&gt; value was set at &lt;0.05.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 84 patients with COPD (25% women) were included in the study. the average age was 71±14 years. The average spirometric values were as follows: FEV1/FVC 61.5±9%, FEV1 64±15% of predicted, and FVC 85.52±13.9% of predicted. Among the COPD patients with sarcopenia, the average REE was significantly lower than patients without sarcopenia (1154±238 kcal/day vs 1230±234 kcal/day, &lt;em&gt;P&lt;/em&gt;=0.01). No statistically significant differences of the average measured REE between COPD patients with and without malnutrition or high inflammatory markers was observed. Bland-Altman plots demonstrated that, among the equations tested, estimated REE using Westerterp equation provided the highest accuracy rate (58.3%) followed by the Scofield equation (57.1%) with the bias and limit of agreement of 26 kcal/day and -288 to +340 kcal/day for Westerterp and +32 kcal/day and -353 to +289 kcal/day for Schofield equation, respectively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Estimation of REE using Schofield and Westerterp equation provides better accuracy rate and lower level of bias in COPD patients across various clinical conditions and may be used for estimation when IC is not available. When FFM measurement is available, Nordenson equation pro","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"63 ","pages":"Pages 226-237"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of gene methylation status RLEP, LEP, FTO, BDNF and COMT with risk factors for eating disorders in Mexican university students","authors":"R.G. Garfias-Guzmán ,&nbsp;M. de Lorena Ramos-García ,&nbsp;C. Castro-Hernández ,&nbsp;L. Casas-Ávila ,&nbsp;O.C. Martínez-Ramírez","doi":"10.1016/j.nutos.2025.06.004","DOIUrl":"10.1016/j.nutos.2025.06.004","url":null,"abstract":"<div><div>Eating Disorders are complex conditions characterized by negatively impact a person's physical and mental health. Risky eating behavior are closely related to risk factors such as BMI, sex, depression, and anxiety.</div></div><div><h3>Aim</h3><div>The objective of this study is to determine the association of gene methylation status RLEP, LEP, FTO, BDNF, and COMT with the risk factors for eating disorders in Mexican university students.</div></div><div><h3>Methods</h3><div>An analytical cross-sectional study was carried out. Data on risky eating behavior, anxiety, and depression were collected using self-applicable questionnaires EAT, BAI, and BECK, respectively. The methylation of the genes was determined by MSP-PCR.</div></div><div><h3>Results</h3><div>We included 83 individuals, 61.4% women, and 38.6% men. Our results showed an association between the risk of eating disorders and anxiety and/or depression. When we determine the interaction between genes and risk factors, we find that the greater the number of risk variables, the greater the association of presenting risky eating behavior in Mexican university students.</div></div><div><h3>Conclusion</h3><div>We found an association between risk factors, especially depression and anxiety, with risky eating behavior in Mexican university students.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"63 ","pages":"Pages 79-90"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}