Clinical Nutrition Open Science最新文献

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A randomized controlled trial of fruit meal sequence with low, moderate, and high glycemic indexes among type 2 diabetes mellitus patients 2 型糖尿病患者低、中、高血糖指数水果餐顺序随机对照试验
Clinical Nutrition Open Science Pub Date : 2024-09-23 DOI: 10.1016/j.nutos.2024.09.005
Dono Indarto , Nuraini Fitri , Fitria Umagapi , Sudrajah Warajati Kisnawaty , Yohanes Cakrapradipta Wibowo , Melani Ratih Mahanani
{"title":"A randomized controlled trial of fruit meal sequence with low, moderate, and high glycemic indexes among type 2 diabetes mellitus patients","authors":"Dono Indarto ,&nbsp;Nuraini Fitri ,&nbsp;Fitria Umagapi ,&nbsp;Sudrajah Warajati Kisnawaty ,&nbsp;Yohanes Cakrapradipta Wibowo ,&nbsp;Melani Ratih Mahanani","doi":"10.1016/j.nutos.2024.09.005","DOIUrl":"10.1016/j.nutos.2024.09.005","url":null,"abstract":"<div><h3>Aim</h3><div>We aimed to study the low, moderate, and high glycemic indexes of fruit meal sequence among T2DM patients in Indonesia by measuring Fasting Blood Glucose (FBG) and insulin levels, Homeostasis model assessment of β-cell function (HOMA-β), and Dipeptidyl peptidase-4 (DPP4) activity.</div></div><div><h3>Methods</h3><div>A randomized controlled trial (RCT), which included 48 participants, was conducted from November 2018 to March 2019. The meal sequence treatments were done in two intervals: 1–7 days fruit last meal (FL) and 14–21 days fruit first meal (FF).</div></div><div><h3>Results</h3><div>Significant differences in insulin and HOMA-β between control and low GI were observed in both intervals. However, no significant changes in Insulin level (5.16±3.47 vs. 5.51±6.16 μIU/ml, p=0.819) and HOMA-β (17.61±11.33 vs. 20.65±17.88, p=0.465) were observed from low GI in two different intervals.</div></div><div><h3>Conclusions</h3><div>Our study clearly uncovered that low GI fruit consumption is beneficial in increasing insulin levels and HOMA-β but is independent of fruit meal sequence. Moderate and high GI fruits showed beneficial effects on insulin levels and HOMA-β only if consumed after the main meal. Although a significant decrease in FBG levels after 7 and 21 days was observed, the analysis on intervals (day 7-1 and 21-14) showed no changes in FBG levels after fruit sequence after or before meal. Further studies are needed to investigate the long-term effects of fruit meal sequence on glycemic parameters.</div><div>This study provides evidence on how fruit meal sequence can directly affect the FBG level, insulin level, and HOMA-β. Given the essential effects of fruit meal sequence, this study gives insight into the integration of optimization of fiber intake from fruits and the meal sequence in T2DM management.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 69-79"},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consumption patterns of grains/cereals, vegetables and fruits and its association with glycemic control among patients with type 2 diabetes mellitus; A cross sectional study 2 型糖尿病患者的谷物、蔬菜和水果消费模式及其与血糖控制的关系;一项横断面研究
Clinical Nutrition Open Science Pub Date : 2024-09-23 DOI: 10.1016/j.nutos.2024.09.008
Mariam John Munyogwa , Festo Phineas Maregesi
{"title":"Consumption patterns of grains/cereals, vegetables and fruits and its association with glycemic control among patients with type 2 diabetes mellitus; A cross sectional study","authors":"Mariam John Munyogwa ,&nbsp;Festo Phineas Maregesi","doi":"10.1016/j.nutos.2024.09.008","DOIUrl":"10.1016/j.nutos.2024.09.008","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>The world is experiencing steady increasing in both number of cases and prevalence of diabetes with urban settings being more affected areas. Good adherence to dietary management is a key non-pharmacological management for effective management of blood glucose for people living with type 2 diabetes. For effective glycemic control, people with diabetes are recommended to eat less carbohydrates (quarter plate size), more fruits and vegetables (half plate size) and more lean protein (quarter plate size). This study aims to assess the consumption patterns of grains/cereals, vegetable and fruits and its association with glycemic control among people living with diabetes.</div></div><div><h3>Materials &amp; Methods</h3><div>The study design was a cross sectional among outpatients attending routine diabetic clinics. Structured questionnaire was used to collect information from the patient through face to face interview. Demographic information, dietary history and selected medical history were collected from patients. Data analysis was done by running the frequencies, percentages, chi-square test and logistics regression at 95% confidence interval.</div></div><div><h3>Results</h3><div>About 109 (33.1%) of respondents were aged less than 40 years. One hundred and fifty-two respondents had been living with diabetes for less than past 5 years 152 (46.2%). More than 80% of the respondents had uncontrolled glycemic. Daily consumption patterns of grains/cereals food were (90.0%), vegetables (97.3%) and fruits (33.4%). Plate portion size consumed were; ≤¼ for grains/cereals (50.5%), ≥¼ for vegetables (96.4%) and ≥¼ for fruits (30.7%). The most types of food consumed were legumes (85.1%), whole grains/cereals (57.1%), leafy green vegetables (70.2%) and low GI fruits (59.9%). The odds of having hyperglycaemia were; increasing with increase in portion size of grains/cereals food (ref: one fifth; one quarter, AOR = 10.22; one third, AOR = 47.19; one half or more, AOR = 42.91); increasing with consumption of high GI fruits (AOR = 2.40) and decreasing with increase in portion size of fruits (AOR = 3.13).</div></div><div><h3>Conclusion</h3><div>Grains/cereals, vegetables and fruits consumption pattern among patient with type 2 diabetes need to improve to achieve optimal blood glucose. Reducing staples portion sizes (grains/cereals), increases portion size for mixed fruits, eating whole grains/cereals and choosing of low GI fruits may help to curb the severity of hyperglycemia among patients with T2DM.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 43-53"},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring trends of macronutrients in Danish human donor milk 探索丹麦人体捐献乳汁中宏量营养素的趋势
Clinical Nutrition Open Science Pub Date : 2024-09-21 DOI: 10.1016/j.nutos.2024.09.009
Lea Holritz , Anne B. Olin , Beate R. Knudsen , Winnie E. Svendsen , Maria Dimaki
{"title":"Exploring trends of macronutrients in Danish human donor milk","authors":"Lea Holritz ,&nbsp;Anne B. Olin ,&nbsp;Beate R. Knudsen ,&nbsp;Winnie E. Svendsen ,&nbsp;Maria Dimaki","doi":"10.1016/j.nutos.2024.09.009","DOIUrl":"10.1016/j.nutos.2024.09.009","url":null,"abstract":"<div><div>Donor milk obtained from milk banks is a source of infant nutrition for mothers that cannot produce their own milk. Milk banks quality control the milk when donated, testing for the presence of pathogenic bacteria, protein and fat concentrations and total energy content. The macronutrient analysis allows the milk bank to decide if they need to add fortifiers to the milk and whether to continue accepting milk from a specific donor. The data registered is a large knowledge base for understanding how the macronutrient content in human milk changes with e.g. time, maternal health and gestational age. Using information from 331 donated milk samples from 74 different donors, all from Denmark, this paper looks at trends in macronutrient content relative to several parameters. Our results show that there is a statistically significant change in content over time and gestational age, but also that other parameters, not covered by the available data, can have an effect on the quality of donated human milk.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 54-68"},"PeriodicalIF":0.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of nutrition adequacy on inflammation, respiratory improvement, and success of weaning from mechanical ventilation in critically ill patients: A single-blind randomized controlled clinical trial 营养充足对重症患者炎症、呼吸系统改善和机械通气断流成功率的影响:单盲随机对照临床试验
Clinical Nutrition Open Science Pub Date : 2024-09-21 DOI: 10.1016/j.nutos.2024.09.006
Hamideh mohammadi , Nafiseh Shokri-Mashhadi , Saeed Abbasi , Hossein Mahjobipoor , Maryam Eghbali Babadi
{"title":"Effect of nutrition adequacy on inflammation, respiratory improvement, and success of weaning from mechanical ventilation in critically ill patients: A single-blind randomized controlled clinical trial","authors":"Hamideh mohammadi ,&nbsp;Nafiseh Shokri-Mashhadi ,&nbsp;Saeed Abbasi ,&nbsp;Hossein Mahjobipoor ,&nbsp;Maryam Eghbali Babadi","doi":"10.1016/j.nutos.2024.09.006","DOIUrl":"10.1016/j.nutos.2024.09.006","url":null,"abstract":"<div><h3>Background</h3><div>This prospective interventional study aimed to investigate the effect of nutritional adequacy through a multidisciplinary approach on the success of ventilator weaning in patients admitted to ICU considering patients' nutritional status at baseline and monitoring nutritional measurements during the study.</div></div><div><h3>Materials and methods</h3><div>In this randomized, single-blind, two-arm clinical trial (IRCT20201229049876N1, Registration date: 2021-01-06), subjects were selected from patients undergoing mechanical ventilation and admitted to the intensive care unit (ICU) of three medical centers between January 2021 and June 2022. The intervention group received multidisciplinary nutritional support rounds twice weekly, while the control group received the usual nutrition therapy (physician-centered NS).</div></div><div><h3>Results</h3><div>Our results showed that 92% of patients in the intervention group had a higher daily energy intake (≥80% of goal Kcal) compared with the control group, 62% of patients (<em>P</em>≤ 0.05). There were no significant differences in terms of BMI, and values of respiratory function parameters between the two groups (all <em>P</em>&gt; 0.1) at the end of the study. However, the mean score of the Burns Wean Assessment Program (BWAP), and circulating levels of C-reactive protein were significantly changed in the interventional group than in the control group.</div></div><div><h3>Conclusion</h3><div>Applying a multidisciplinary nutrition support program could improve nutrition adequacy, CRP levels, and the BWAP score in ventilated ICU patients.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 227-238"},"PeriodicalIF":0.0,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalized approaches to the prescription of protein-based oral nutritional supplements in older adults: A scoping review 老年人蛋白质口服营养补充剂处方的个性化方法:范围综述
Clinical Nutrition Open Science Pub Date : 2024-09-20 DOI: 10.1016/j.nutos.2024.09.007
Catherine M. Fallon , Clare A. Corish , Katy Horner , Caitriona Cunningham
{"title":"Personalized approaches to the prescription of protein-based oral nutritional supplements in older adults: A scoping review","authors":"Catherine M. Fallon ,&nbsp;Clare A. Corish ,&nbsp;Katy Horner ,&nbsp;Caitriona Cunningham","doi":"10.1016/j.nutos.2024.09.007","DOIUrl":"10.1016/j.nutos.2024.09.007","url":null,"abstract":"<div><h3>Background and aims</h3><div>Oral nutritional supplements (ONS) are prescribed for older adults with malnutrition and sarcopenia to prevent nutritional and functional deterioration. Studies investigating ONS effectiveness commonly provide the same ONS prescription for participants. This scoping review aimed to provide an overview of studies that have personalized ONS prescription in older adults with malnutrition or sarcopenia.</div></div><div><h3>Methods</h3><div>In July 2023, PubMed, CINAHL, SCOPUS and EMBASE were searched for studies wherein older adults with malnutrition, risk of malnutrition or sarcopenia received personalized ONS. Data extracted were synthesized into tables and descriptively summarized.</div></div><div><h3>Results</h3><div>Fifteen studies met the inclusion criteria, all in developed countries: 10 randomized controlled, 3 cross-over, 1 non-randomized and 1 single-arm trials. Fourteen studies included older adults at risk of malnutrition/malnourished. One study included older adults with sarcopenia. Studies included between 34 and 671 participants aged 70–88 years. Dietitians (10 studies) or trained nutritionists (5 studies) personalized the ONS prescription. Personalization included: (i) providing ONS for protein requirements based on weight (11 studies) or (ii) current dietary intake (2 studies), or (iii) offering ONS flavors based on personal preference (2 studies). Outcome measures included nutritional status, change in body weight/composition and quality of life. Definition and methods of assessing adherence varied. Seven studies showed a significant improvement in primary outcomes when personalized ONS were prescribed.</div></div><div><h3>Conclusion</h3><div>15 studies which personalized ONS for older adults with malnutrition/sarcopenia were identified. Further research on optimizing personalized approaches with standardized outcome measures is warranted.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 80-103"},"PeriodicalIF":0.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular mechanisms and therapeutic effects of natural products in inflammatory bowel disease 天然产品在炎症性肠病中的分子机制和治疗效果
Clinical Nutrition Open Science Pub Date : 2024-09-17 DOI: 10.1016/j.nutos.2024.09.004
Azadeh Aghamohammadi Sendani , Maryam Farmani , Nesa Kazemifard , Shaghayegh Baradaran Ghavami , Amir Sadeghi
{"title":"Molecular mechanisms and therapeutic effects of natural products in inflammatory bowel disease","authors":"Azadeh Aghamohammadi Sendani ,&nbsp;Maryam Farmani ,&nbsp;Nesa Kazemifard ,&nbsp;Shaghayegh Baradaran Ghavami ,&nbsp;Amir Sadeghi","doi":"10.1016/j.nutos.2024.09.004","DOIUrl":"10.1016/j.nutos.2024.09.004","url":null,"abstract":"<div><div>The etiology of inflammatory bowel disease (IBD) is intricately influenced by the complex interplay of environmental factors, alterations in gut flora, genetic predisposition, and modifications in the immune system. The global incidence of IBD has surged significantly in recent decades, with reports of nutritional deficiencies among affected individuals. Nutritional factors can exacerbate intestinal inflammation by disrupting immune responses, modifying gut barrier integrity, impacting the mucosal layer and fostering microbial imbalances. As a result, modifications to dietary intake and nutritional supplementation are regarded as additional components of common IBD treatment strategies. This review delves into the properties, cellular pathways and the research outcomes examining the efficacy of dietary nutritional supplements like curcumin, resveratrol, selenium, quercetin, and vitamin D as supportive therapy for IBD patients.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 21-42"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142318840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial special section “Advancing the understanding of sensory and nutritional health through multidisciplinary research” 编辑专栏 "通过多学科研究促进对感官和营养健康的了解"
Clinical Nutrition Open Science Pub Date : 2024-09-11 DOI: 10.1016/j.nutos.2024.09.003
A. Giboreau, F. Carrouel
{"title":"Editorial special section “Advancing the understanding of sensory and nutritional health through multidisciplinary research”","authors":"A. Giboreau,&nbsp;F. Carrouel","doi":"10.1016/j.nutos.2024.09.003","DOIUrl":"10.1016/j.nutos.2024.09.003","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 10-12"},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667268524000858/pdfft?md5=c4744d5fa57e484a8220d4b7295b795f&pid=1-s2.0-S2667268524000858-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malnutrition and other factors associated with hospitalization in older adults treated at the naval medical center of Callao - Peru 在秘鲁卡亚俄海军医疗中心接受治疗的老年人的营养不良及其他住院相关因素
Clinical Nutrition Open Science Pub Date : 2024-09-06 DOI: 10.1016/j.nutos.2024.09.002
Karla M. Joo , Hellen L. La Torre , Alvaro Bendezú , Ericson L. Gutierrez , Willy Ramos , Jhony A. De La Cruz-Vargas , José F. Parodi , Fernando M. Runzer-Colmenares
{"title":"Malnutrition and other factors associated with hospitalization in older adults treated at the naval medical center of Callao - Peru","authors":"Karla M. Joo ,&nbsp;Hellen L. La Torre ,&nbsp;Alvaro Bendezú ,&nbsp;Ericson L. Gutierrez ,&nbsp;Willy Ramos ,&nbsp;Jhony A. De La Cruz-Vargas ,&nbsp;José F. Parodi ,&nbsp;Fernando M. Runzer-Colmenares","doi":"10.1016/j.nutos.2024.09.002","DOIUrl":"10.1016/j.nutos.2024.09.002","url":null,"abstract":"<div><h3>Purpose</h3><p>Older adults have a higher risk of malnutrition and hospitalization and, likewise, malnutrition can be a risk factor for hospitalization. The purpose of the present study was to determine the possible association between malnutrition and hospitalization in older adults at the Naval Medical Center “Cirujano Mayor Santiago Távara\" in Peru.</p></div><div><h3>Patients and Methods</h3><p>A cross-sectional analytical study was conducted in older adults over 60 years of age attended by the outpatient and Day Clinic during the period 2010–2015. Malnutrition was assessed using the Mini Nutritional Assessment scale. Multivariate analysis of the association between malnutrition and hospitalization with control of confounding variables was performed using a Poisson regression model with robust variance, obtaining an adjusted prevalence ratio (aPR).</p></div><div><h3>Results</h3><p>The study included 1865 older adults. 58.7% were male, and 46% were between 70 and 80 years of age. 16.3% had malnutrition, 80.6% had at least one emergency department visit, and 35.6% were hospitalized at least once. Multivariate analysis showed a statistically significant association between malnutrition and hospitalization (aPR = 3.22; 95% confidence interval [CI]: 2.56–4.03), as well as between depressive symptoms and hospitalization (aPR = 1.54; 95% CI: 1.23–1.93). On the other hand, emergency department visits were associated with a lower frequency of hospitalization (aPR = 0.70; 95% CI: 0.54–0.90).</p></div><div><h3>Conclusion</h3><p>Malnutrition and depressive symptoms were associated with hospitalization in retired naval personnel and their families at the Naval Medical Center, while emergency department visits constituted a protective factor.</p></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667268524000846/pdfft?md5=72a9f62a40f13fbe1c5c27e1782eb012&pid=1-s2.0-S2667268524000846-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trajectory of bodyweight and skeletal muscle mass in patients treated with nintedanib for idiopathic pulmonary fibrosis 接受宁替达尼治疗的特发性肺纤维化患者体重和骨骼肌质量的变化轨迹
Clinical Nutrition Open Science Pub Date : 2024-09-05 DOI: 10.1016/j.nutos.2024.09.001
Hiromi Tomioka , Takashi Fujikawa
{"title":"Trajectory of bodyweight and skeletal muscle mass in patients treated with nintedanib for idiopathic pulmonary fibrosis","authors":"Hiromi Tomioka ,&nbsp;Takashi Fujikawa","doi":"10.1016/j.nutos.2024.09.001","DOIUrl":"10.1016/j.nutos.2024.09.001","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Nintedanib is currently a therapeutic option for idiopathic pulmonary fibrosis (IPF). Weight loss is a common complication of IPF and a side effect of nintedanib, inducing loss of skeletal muscle mass and musculoskeletal dysfunction. Thus far, few clinical studies have investigated the relationship between skeletal muscle mass and bodyweight in patients with IPF receiving nintedanib.</div></div><div><h3>Methods</h3><div>In this analysis, we evaluated pooled data obtained from a retrospective investigation of treatment with nintedanib for &gt;6 months in patients with IPF. We assessed changes in bodyweight and skeletal muscle mass by determining the pectoralis major and minor muscle cross-sectional areas (PMcsa) by chest computed tomography before and after nintedanib therapy.</div></div><div><h3>Results</h3><div>In the cross-sectional study (n=55), PMcsa at baseline was 13.0±3.0 cm<sup>2</sup> and significantly correlated with age (r=−0.31, <em>P</em>=0.023), bodyweight (r=0.63, <em>P</em>&lt;0.0001), and 6-min-walk distance (r=0.31, <em>P</em>=0.037). In the longitudinal study (n=33), significant PMcsa loss subsequent to the administration of nintedanib was observed (−1.1±1.4 cm<sup>2</sup>, 95% confidence interval: -1.6, -0.6, <em>P</em>=0.0001), and this effect was significantly related to weight loss (r=0.44, <em>P</em>=0.010). PMcsa loss was not significant during 6 months prior to nintedanib administration (−0.2±2.0 cm<sup>2</sup>, 95% confidence interval: -0.9, 0.5, <em>P</em>=0.60), and the observed changes were not significantly related to changes in bodyweight (r=-0.0347, <em>P</em>=0.848).</div></div><div><h3>Conclusions</h3><div>Following treatment with nintedanib, significant skeletal muscle mass loss was recorded, and this effect was significantly associated with bodyweight loss. Monitoring of bodyweight is important during nintedanib therapy.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 13-20"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667268524000834/pdfft?md5=ca441765653387dac356aeb830ad75b2&pid=1-s2.0-S2667268524000834-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional diagnoses and interventions in people with metabolic dysfunction-associated fatty liver disease:Cross-sectional study 代谢功能障碍相关性脂肪肝患者的营养诊断和干预:横断面研究
Clinical Nutrition Open Science Pub Date : 2024-08-28 DOI: 10.1016/j.nutos.2024.08.009
Silvia Moro Conque Spinelli, Maria de Fátima Mantovani, Maria Eliana Madalozzo Schieferdecker, Robson Giovani Paes
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