Clinical Nutrition Open Science最新文献

{"title":"The role of bioimpedance in determining protein intake after ICU care","authors":"Cristian Deana ,&nbsp;Alessia Marin ,&nbsp;Michele Umbrello ,&nbsp;Daniele Guerino Biasucci ,&nbsp;Laura Di Meo ,&nbsp;Luigi Vetrugno","doi":"10.1016/j.nutos.2025.10.012","DOIUrl":"10.1016/j.nutos.2025.10.012","url":null,"abstract":"<div><div>Nutrition in critically ill patients after intensive care unit (ICU) discharge is frequently omitted and still poorly investigated.</div><div>Patients during ICU stay experience great muscle loss that is the main cause of ICU-acquired weakness with consequent physical disability, including difficult eating. Moreover, ICU survivors have an altered nutritional status, may present dysphagia, taste alterations and mood disorders which in turn could aggravate malnutrition.</div><div>For this purpose, body composition should be determined in critically ill patients not only during ICU stay, but also after discharge to the rehabilitation units where muscle mass could be restored with adequate nutrition and exercise.</div><div>Recent advances highlight how a personalized nutrition could optimize nutritional status in critically ill patients. Bioimpedance analysis is a useful tool to determine body composition in post-ICU period, determining lean body mass, which is the effective part of body weight metabolically active. Moreover, it could allow for a suitable protein dosage prescription optimized on lean body mass of the patient and not on a fixed amount calculated on generic formula based on body weight.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 230-240"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega-3 fatty acids in addition to standard of care in the treatment of critically ill patients with COVID-19 (The OMEGA-COVID study), a randomized controlled multicenter trial","authors":"Ahmed Abd Elaziz Bahey Abd Elbari ,&nbsp;Sandro B. Rizoli ,&nbsp;Ruben Peralta ,&nbsp;Talat Chughtai ,&nbsp;Ayman El-Menyar ,&nbsp;Hassan Ali Saoud Al Thani ,&nbsp;Saibu George ,&nbsp;Nadir Kharma ,&nbsp;Mohammed Omar Saad ,&nbsp;Hasan Mitwally ,&nbsp;Mohamed Elkhateeb ,&nbsp;Mostafa Elshafi ,&nbsp;Ignacio Miguel Gomez Macineira ,&nbsp;Anyali Bacallao ,&nbsp;Ammar Ibrahim Abed Al-Hassani ,&nbsp;Ibrahim Yassin Taha ,&nbsp;Judith Jacobi ,&nbsp;Airton Leonardo de Oliveira Manoel","doi":"10.1016/j.nutos.2025.08.011","DOIUrl":"10.1016/j.nutos.2025.08.011","url":null,"abstract":"<div><h3>Background</h3><div>The efficacy and safety of omega-3 fatty acid in the treatment of severe acute respiratory syndrome remains controversial. We assessed if the addition of omega-3 fatty acid to standard of care would improve clinical outcomes in patients with SARS-CoV-2.</div><div>Methods: double blinded randomized clinical trial of adults with PCR-confirmed severe or critical COVID-19. Patients were enrolled through block stratified randomization to omega-3 fatty acid 2g enterally twice daily for 28 days in addition to standard of care vs. standard of care alone. The primary outcome was ventilator-free days at day 28. Secondary outcomes included length of ICU and hospital stay, and in-hospital mortality.</div></div><div><h3>Results</h3><div>380 patients (211 in the intervention group and 169 patients in the standard of care group). Ventilator-free days were similar between the intervention and standard of care groups [mean 12.4 days (9.3–15.5) vs 11.1 (7.2–15.0), <em>P</em> = 0.48), respectively]. There was no difference in the length of ICU (7 days for both groups) or hospital stay (Omega-3 = 16 days vs control = 15 days). Patients who received Omega-3 fatty acid had a trend toward lower mortality (4.3% vs 7.7%, <em>P</em> = 0.15). In pre-specified exploratory subgroup of mechanically ventilated patients (89 patients), Omega-3 group was associated with a significantly lower mortality (15.1% vs 33.3%, <em>P</em> = 0.04), however, the trial was not powered to detect mortality differences in this subgroup.</div></div><div><h3>Conclusions</h3><div>In patients with severe or critical COVID-19, the addition of Omega-3 fatty acids to standard of care did not increase ventilator-free days. An exploratory analysis suggested a possible mortality benefit in patients requiring mechanical ventilation, but the study was not powered for this endpoint, and these findings require confirmation in future trials.</div></div><div><h3>Trial Registration</h3><div>ClinicalTrials.gov, NCT04836052.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 13-24"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aquatic foods in human health, nutrition, and overall welfare","authors":"Koshal Kumar","doi":"10.1016/j.nutos.2025.11.005","DOIUrl":"10.1016/j.nutos.2025.11.005","url":null,"abstract":"<div><div>This paper deals with the role of aquatic foods in human health, nutrition, welfare, etc. Earth is covered with 70% water, and approximately 30% of the human population lacks adequate nutrition. Aquatic foods are essential for improving human global health and nutrition levels. Japan consumes more aquatic plant and animal products than any other nation, reports the lowest rates of obesity and heart disease, and has one of the longest human life spans in the world. According to the FAO, over three billion people consume more than 20% of animal protein per person, and 4.3 billion people consume at least 15%. Aquatic foods play an essential role in the nutrition of humans and provide them with animal protein, vital amino acids, omega-3 fatty acids, vitamins, minerals, trace elements, etc. Aquatic foods from plant and animal sources provide vital nutrients to humans that promote health and prevent disease.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 332-342"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on factors influencing thirst perception during oral nutritional supplement intake in cancer patients","authors":"Ghias Kulsoom,&nbsp;Gupta Ananya","doi":"10.1016/j.nutos.2025.08.013","DOIUrl":"10.1016/j.nutos.2025.08.013","url":null,"abstract":"<div><div>Cancer patients undergoing treatment frequently experience malnutrition due to disease-related factors and side effects of therapies like chemotherapy and radiotherapy. Oral Nutritional Supplements (ONS) play a pivotal role in maintaining nutritional status and improving treatment outcomes. However, adherence to ONS is often poor, influenced by sensory properties such as taste, viscosity, saltiness, and protein content. Thirst perception, an underexplored factor, may also impact ONS adherence, particularly in patients managing xerostomia, dysgeusia, and other treatment-related changes in oral sensations. This cross-sectional sensory evaluation study included 56 cancer patients, of whom 29 participated in detailed sensory testing. The study systematically evaluated the effects of varying salt levels, protein concentrations, and viscosity in ONS formulations on thirst perception, mouth dryness, and sensory acceptability in cancer patients. Modified ONS formulations, including low, medium, and high levels of salt, protein, and viscosity, were compared to a control. Participants completed sensory evaluations using visual analogue scales (VAS) and hedonic scales to rate thirst, mouthfeel, taste, and overall liking. Subgroup analyses examined the influence of patient-specific factors, such as dysgeusia and hydration habits, on these responses. Results indicated that high-salt (1g) and high-protein (5.5 g protein/30ml) formulations were associated with higher thirst perception (VAS scores ≥45 mm) compared to low-salt (0.33g) and low-protein (4.7g protein/30ml) formulations (VAS scores ≤27 mm). Low-viscosity (50 cP) formulations were preferred for their smoother texture, while high-viscosity (250 cP) samples elicited greater thirst due to mouth-coating effects. Dysgeusia amplified thirst and reduced liking scores for high-salt and high-protein ONS. These findings highlight the need for patient-centred ONS formulations that minimize thirst stimulation while enhancing palatability. Optimizing ONS properties may improve adherence and nutritional outcomes for cancer patients, although further studies are needed to confirm any direct impact on quality of life or treatment outcomes.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 84-100"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional status and determinants of malnutrition among under-five children in a specialized hospital in Bangladesh during the COVID-19 pandemic","authors":"Mukta Pasha ,&nbsp;Md. Monir Hossain Shimul ,&nbsp;Roman Hossain ,&nbsp;Salamat Khandker ,&nbsp;Salim khan ,&nbsp;Nadira Mehriban","doi":"10.1016/j.nutos.2025.10.008","DOIUrl":"10.1016/j.nutos.2025.10.008","url":null,"abstract":"<div><h3>Background</h3><div>Child malnutrition remains a pressing public health issue in Bangladesh, worsened by the socioeconomic consequences of the COVID-19 pandemic. Identifying nutritional status and its associated factors among children under five is critical to guide interventions.</div></div><div><h3>Methods</h3><div>A hospital-based cross-sectional study was conducted from June to August 2021 at the Institute of Child and Mother Health (ICMH), Dhaka. A total of 543 children aged 6–59 months were selected using systematic random sampling. Data were collected via a pretested semi-structured questionnaire and anthropometric measurements following WHO standards. Nutritional outcomes (stunting, wasting, underweight, and MUAC) were analyzed using descriptive statistics, chi-square tests, and multivariate logistic regression.</div></div><div><h3>Results</h3><div>Among the 543 children studied, 37.6 % were stunted, 22.8 % were underweight, and 3.9 % were wasted, with 64.3 % experiencing at least one form of malnutrition. Malnutrition was more common among males and children aged 6–12 months. Independent predictors of malnutrition included maternal underweight (BMI &lt;18.5 kg/m²; AOR = 2.87), recent diarrheal disease exposure (AOR = 5.23), and infectious disease exposure (AOR = 2.26). Children of mothers with low education (AOR = 2.37, p &lt; 0.001) and from low-income families (AOR = 2.01, p &lt; 0.001) had higher risk. Exclusive breastfeeding was protective against malnutrition (AOR = 0.39, p = 0.022). Underweight was predicted by maternal underweight (AOR = 2.58, p = 0.004), diarrheal exposure (AOR = 4.34, p &lt; 0.001), and low maternal education (AOR = 2.37, p = 0.002). Stunting was associated with low family income (AOR = 2.01, p = 0.009), maternal underweight (AOR = 2.07, p = 0.006), and exposure to diarrheal (AOR = 2.73, p = 0.001) or infectious diseases (AOR = 3.19, p &lt; 0.001). Wasting was linked to maternal underweight (AOR = 3.13, p = 0.004) and diarrheal exposure (AOR = 4.47, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The study revealed a high burden of malnutrition among hospitalized under-five children during the COVID-19 pandemic, exceeding national averages for stunting and underweight. Maternal nutrition, education, and child health exposures were key determinants. Interventions should prioritize maternal nutrition, breastfeeding promotion, and prevention of diarrheal and infectious diseases.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 192-202"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to a Mediterranean diet and severity of pain and gastrointestinal symptoms in people with Rheumatoid Arthritis: A cross-sectional analysis","authors":"Briana Fahey ,&nbsp;Tayla White ,&nbsp;Evangeline Mantzioris ,&nbsp;Elke Sokoya ,&nbsp;Anthony Villani","doi":"10.1016/j.nutos.2025.09.005","DOIUrl":"10.1016/j.nutos.2025.09.005","url":null,"abstract":"<div><h3>Background</h3><div>Diet quality may be an important modifiable risk factor for managing the intensity of symptoms and disease progression in people with Rheumatoid Arthritis (RA). Therefore, the objective of this study was to explore the independent associations between adherence to a Mediterranean diet (MedDiet) and severity of pain and gastrointestinal (GI) symptoms in adults with RA.</div></div><div><h3>Methods</h3><div>This was a cross-sectional online survey of community-dwelling adults (≥18 years) with a confirmed medical diagnosis of RA. MedDiet adherence was assessed using the Mediterranean Diet Adherence Screener (MEDAS); the Rheumatoid Arthritis Pain Scale (RAPS) was used to assess the intensity of pain; and severity of GI symptoms was assessed using the Structured Assessment of Gastrointestinal Symptoms Scale (SAGIS).</div></div><div><h3>Results</h3><div>A total of <em>n</em> = 80 participants commenced the online questionnaire (67 female; 12 males; 1 unspecified, 54.7 ± 13.8 years; BMI 29.1 ± 7.2 kg/m2), of which <em>n</em> = 70 completed in full and were included in the final analyses. Participants reported a low-moderate MedDiet adherence (4.9 ± 2.3; range: 1–11) and reported moderate levels of pain (RAPS: 81.4 ± 3.8; range: 0–144) and a low severity of GI symptoms (SAGIS: 10 (19); range 0–51). After adjusting for age, gender, BMI, physical activity duration, years active with disease and use of antirheumatic prescription medication, we found that MedDiet adherence was not related to pain (β: -0.10; 95 % CI: -0.02, 0.01; <em>P</em> = 0.44) or severity of GI symptoms (β: -0.09; 95 % CI: 0.06, 0.03; <em>P</em> = 0.49).</div></div><div><h3>Conclusion</h3><div>Adherence to a MedDiet was not related to severity of pain or GI disturbances in this sample of RA participants. Nevertheless, further exploration of how diet and nutrition can attenuate RA progression and symptom management is important for the development of evidence-based guidelines and dietary recommendations for patients with RA.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 101-114"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A network meta-analysis of the clinical efficacy of different dietary patterns in the treatment of adult metabolic dysfunction-associated steatotic liver diseases","authors":"Diwen Yu ,&nbsp;Peipei Yu ,&nbsp;Wanting Huang ,&nbsp;Pengwei Zhang ,&nbsp;Li Li","doi":"10.1016/j.nutos.2025.11.006","DOIUrl":"10.1016/j.nutos.2025.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Deipite considerable literature supports the benefits of dietary interventions for Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), the most effective dietary approach remains unclear. We conducted a systematic review and network meta-analysis (NMA) to assess the relative efficacy of different dietary approaches on improving liver function, Controlled Attenuation Parameter (CAP), body weight and Body Mass Index (BMI) in adults with MASLD.</div></div><div><h3>Methods</h3><div>We searched PubMed, the Cochrane Library, Embase and Web of Science up to March 2025 for controlled trials of different dietary approaches in adult MASLD patients. Primary outcomes were liver function and CAP, with secondary outcomes being body weight and BMI. For each outcome, the pooled effect of each intervention compared with others was determined. Mean differences (MDs) and 95% confidence intervals (95%CI) were calculated. The surface under the cumulative ranking curve (SUCRA) was used to rank dietary approaches.</div></div><div><h3>Results</h3><div>Overall, 30 trials were included, comparing five macronutrient approaches (Moderate macronutrients, Low carbohydrate (LCD), Low fat, Dietary advice, and Usual diet) and 12 dietary interventions [Atkins, DASH, Weight Watchers, Volumetrics, Low sugar diet, Low GI diet (LGID), Calorie Restriction (CR), Portfolio, Mediterranean, Low fat diet (LFD), Dietary advice, and Usual diet], involving 2051 patients. Regarding macronutrients, Moderate macronutrients demonstrated the most effective improvement in liver function (SUCRA: 76.35%); LCD proved most effective for improving both CAP (SUCRA: 91.5%) and body weight (SUCRA: 94.35%). Among dietary patterns, Portfolio was most effective for improving liver function (SUCRA: 85%), while LGID was most effective for improving CAP (SUCRA: 74.9%); The Atkins diet demonstrated the best overall improvement in body mass and BMI (SUCRA: 76.55%).</div></div><div><h3>Conclusions</h3><div>Moderate macronutrients and Portfolio diets were most effective for improving liver function, while LGID was the most effective approach for reducing CAP. The LCD and Atkins diets were considered the most effective dietary approaches for comprehensively improving body mass and BMI.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 357-376"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145680809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The association between dietary fat intake and benign breast diseases: a systematic review” [Clin Nutr Open Sci 62 (2025) 102–113]","authors":"Amir Hossein Faghfouri ,&nbsp;Fatemeh Azizi-Soleiman ,&nbsp;Sevda Saleh-Ghadimi ,&nbsp;Hamed Jafari-Vayghan","doi":"10.1016/j.nutos.2025.09.003","DOIUrl":"10.1016/j.nutos.2025.09.003","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Page 391"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Vitamin A deficiency among children under five years attending Borama General Hospital in Borama district, awdal, Somaliland","authors":"Deka Ali Mumin ,&nbsp;Abdisamed Hashi Wais ,&nbsp;Jasiah Osiris ,&nbsp;Abdikasim Hashi Wais ,&nbsp;Shamsedin Mahdi Hassan","doi":"10.1016/j.nutos.2025.10.005","DOIUrl":"10.1016/j.nutos.2025.10.005","url":null,"abstract":"<div><div>This study investigated the determinants of vitamin A deficiency among children under five years attending Borama General Hospital in Borama District, Somaliland. Specifically, it assessed the influence of maternal knowledge, parental socio-economic status, and cultural factors on the vitamin A status of children. A cross-sectional survey was conducted with a stratified random sample of 108 mothers. Data were analysed using chi-square tests to determine associations between the selected determinants and vitamin A deficiency. The findings showed that parental socioeconomic status had a significant effect on vitamin A deficiency (χ² = 11.401, df = 4, <em>P</em> = 0.022), whereas maternal knowledge (χ² = 7.174, df = 4, <em>P</em> = 0.127) and cultural factors (χ² = 10.990, df = 2, <em>P</em> = 0.216) were not significantly associated with vitamin A status. The study concludes that household socioeconomic conditions are the primary determinants of vitamin A deficiency in children under five in Borama District. It recommends the interventions aimed at improving parental education, income, and occupation to reduce the prevalence of vitamin A deficiency and suggests further research to investigate barriers to uptake of vitamin A supplementation among mothers.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 203-211"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between frequency of seaweed intake and frailty in Japanese elderly men and women: A cross-sectional study","authors":"Han Seungah ,&nbsp;Masayoshi Ishida ,&nbsp;Yoshino Murakami ,&nbsp;Motoyuki Iemitsu ,&nbsp;Oh Taewoong ,&nbsp;Kiyoshi Sanada","doi":"10.1016/j.nutos.2025.10.003","DOIUrl":"10.1016/j.nutos.2025.10.003","url":null,"abstract":"<div><h3>Purpose</h3><div>Seaweed is rich in minerals, vitamins, fibers, and protein, suggesting that intake of high levels of seaweed might contribute to a lower prevalence of frailty. Accordingly, the present study aimed to examine the association between seaweed intake and pre-frailty in elderly Japanese men and women.</div></div><div><h3>Methods</h3><div>This cross-sectional study collected data from 109 elderly individuals aged 65–90 years living in Oga City, Japan. Seaweed intake was assessed using a brief self-administered diet history questionnaire (BDHQ), and participants were classified into two groups (i.e., High Intake (HI) group and Low Intake (LI) group) according to weekly intake frequency. A binary logistic regression model was used to examine the relationship between seaweed intake and pre-frailty.</div></div><div><h3>Results</h3><div>The HI group had a lower body weight and BMI compared to the LI group. Additionally, the HI group showed faster gait speed and Timed Up and Go (TUG) performance, as well as a greater distance in the 2-step test (<em>p</em> &lt; .01), compared to the LI group. Seaweed intake was inversely associated with physical pre-frailty and cognitive frailty, while no association was found with social pre-frailty.</div></div><div><h3>Conclusion</h3><div>Seaweed intake was significantly and inversely associated with physical pre-frailty and cognitive frailty, suggesting that high seaweed intake may be beneficial against frailty in elderly men and women.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 161-169"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}