Clinical Nutrition Open Science最新文献

{"title":"Peripheral parenteral nutrition in hospitalized patients: Insights from an expert opinion","authors":"Alessandro Laviano ,&nbsp;Paolo Pasquero ,&nbsp;Emanuele Rinninella ,&nbsp;Lidia Santarpia","doi":"10.1016/j.nutos.2025.09.006","DOIUrl":"10.1016/j.nutos.2025.09.006","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Peripheral parenteral nutrition (PPN) is considered a viable alternative to central parenteral nutrition (CPN) for patients requiring short-term nutritional support or presenting contraindications to CPN, but may also be an independent nutritional therapy with specific indications. Furthermore, supplemental PPN may represent a valuable approach for patients unable to meet their nutritional needs through oral or enteral nutrition alone. Frequently, complex situations may prevent physicians from fully adhering to the recommendations of the ESPEN (European Society for Clinical Nutrition and Metabolism) Guidelines. Therefore, a panel of experts convened to identify the appropriate PPN use in surgery and internal medicine departments, aiming to highlight the patient populations suitable for PPN within these hospital settings.</div></div><div><h3>Methods</h3><div>The panel examined the literature and the main recommendations from the ESPEN Guidelines on PPN for adult patients within surgical and medical settings. They subsequently shared their clinical insights and experiences, ultimately describing the clinical scenarios which could potentially benefit from PPN use.</div></div><div><h3>Results</h3><div>PPN use may benefit perioperative care and the management of inflammatory bowel disease, hepatic cirrhosis, acute pancreatitis, oncology, dementia or chronic neurodegenerative diseases, anorexia nervosa, chronic obstructive pulmonary disease, chronic intestinal failure dependent on parenteral nutrition and prolonged fasting in malnourished patients admitted to emergency departments.</div></div><div><h3>Conclusions</h3><div>PPN may facilitate the timely implementation of nutritional support and effectively manage malnutrition. Prompt initiation of PPN may act as a bridge to long-term nutritional strategies, avoiding harmful delays. Further investigations are warranted to assess non-nutritional markers for short-term PPN effects.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 115-135"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of oxalate content in commercial cranberry supplements","authors":"Christina A. Ackerman,&nbsp;Madison B. Brock,&nbsp;Paulina Rivera,&nbsp;Matthew J. Fhaner,&nbsp;Jessica L. Kelts","doi":"10.1016/j.nutos.2025.10.014","DOIUrl":"10.1016/j.nutos.2025.10.014","url":null,"abstract":"<div><div>Kidney stones are a common ailment that is painful to individuals and costly to the US healthcare system. The vast majority of those kidney stones are composed of calcium oxalate, with or without calcium phosphate. Individuals prone to kidney stones follow dietary guidelines to reduce the chance of recurrence. These guidelines focus on lowering the amount of calcium and/or oxalate in the urine to prevent formation of new stones. Many vegetables and some fruits have sizable oxalate content and could contribute to stone formation. It is also known that supplementation with vitamin C is associated with higher oxalate excretion as oxalate is a metabolite of vitamin C metabolism. However, oxalate content of other types of supplements has not been quantified. In this study, we examine several cranberry supplements for their soluble oxalate content. Cranberry supplements are often recommended to patients with recurrent urinary tract infections and/or overactive bladder and are touted by advertisers as supportive of urinary tract health. The level of oxalate found in these supplements was low enough that their consumption would not be contraindicated for most kidney stone patients.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 313-320"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating phase angle in malnutrition risk assessment using nutritional screening tools","authors":"Damla Zeynep Bayraktar ,&nbsp;Serap Andac ,&nbsp;Negin Elmas","doi":"10.1016/j.nutos.2025.10.002","DOIUrl":"10.1016/j.nutos.2025.10.002","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Malnutrition is a common complication in patients with breast cancer and is associated with adverse clinical outcomes. Phase angle (PhA), a parameter derived from bioelectrical impedance analysis (BIA) may reflect nutritional status, but its value versus standard tools remains unclear. This study aims to evaluate the utility of PhA in detecting malnutrition risk in breast cancer patients, compared with four validated screening tools.</div></div><div><h3>Methods</h3><div>This cross-sectional observational study included 98 female patients with breast cancer. Nutritional status was assessed using the Nutritional Risk Screening 2002 (NRS-2002), Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF), Malnutrition Universal Screening Tool (MUST), and Malnutrition Screening Tool (MST). PhA was measured using single-frequency (50 kHz) BIA. Receiver Operating Characteristic (ROC) analysis was used to determine the optimal PhA cut-off for malnutrition risk. Associations between PhA and malnutrition risk were examined univariate and multivariate logistic regression analyses.</div></div><div><h3>Results</h3><div>PhA was significantly associated with nutritional risk across all four screening tools. The optimal PhA cut-off for malnutrition risk based on NRS-2002 was 5.04 degrees (AUC = 0.83), with 73% sensitivity and 87% specificity. In crude logistic regression, a PhA &lt;5.04 degrees significantly increased malnutrition risk across all screening tools: NRS-2002 (OR = 0.178, p &lt; 0.001), MUST (OR = 0.338, p = 0.005), MST (OR = 0.308, p &lt; 0.001), and PG-SGA SF (OR = 0.481, p = 0.037). These associations remained statistically significant after adjustment for age and fat mass index in three models (excluding PG-SGA SF).</div></div><div><h3>Conclusion</h3><div>PhA, appears to be a practical and supportive indicator for identifying malnutrition risk in breast cancer patients, particularly when used alongside validated screening tools. The identified cut-off value (5.04 degrees) may serve as a useful threshold in clinical practice.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 147-160"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional treatment after discharge of older patients at nutritional risk: A single-arm feasibility study","authors":"Martine Kjærsgaard Nielsen ,&nbsp;Tina Munk ,&nbsp;Anne Marie Beck ,&nbsp;Jacob Rosenberg ,&nbsp;Jesper Ryg","doi":"10.1016/j.nutos.2025.10.009","DOIUrl":"10.1016/j.nutos.2025.10.009","url":null,"abstract":"<div><h3>Background</h3><div>Malnutrition is common among older hospitalized patients and is linked to poor outcomes. While the transition between healthcare sectors is important for ensuring adequate nutrition, nutritional interventions have not been effectively implemented. This study aimed to evaluate the feasibility of the study design in older patients at nutritional risk following hospital discharge, focusing on eligibility, recruitment, retention, and data collection.</div></div><div><h3>Methods</h3><div>This feasibility study was conducted at Copenhagen University Hospital Herlev and Gentofte for a period of three months. Older patients at nutritional risk who were discharged with the liaison team received a food package that covered their nutritional requirements for 24 hours, along with individualized nutritional counselling provided at 2–4 days and 30 days post-discharge. The primary outcome was feasibility, assessed as eligibility, recruitment, retention, feasibility of data collection, and overall study design. The secondary outcome was compliance with nutritional counselling.</div></div><div><h3>Results</h3><div>Of 76 screened patients, 100% were eligible for participation. A total of 62 (82%) patients met the inclusion criteria and none of the exclusion criteria. During the study period, 31 (79%) accepted to participate, reflecting an inclusion rate of 1.8 patients/week. Retention in the study was 73%. Overall, data collection completeness at baseline exceeded 80%, except for three measures: nutritional risk screening by hospital staff, clinical frailty scale, and performance of 30-second chair stand test. From day 2–4 to day 30, there was an increase in the proportion of patients achieving ≥75% of their estimated requirement for energy (<em>P</em>=0.008) and protein (<em>P</em>=0.014).</div></div><div><h3>Conclusion</h3><div>Overall, the study design demonstrated that the intervention was feasible. We found high eligibility, data completeness, and compliance with the nutritional counselling in relation to energy and protein intake. However, the recruitment rate and retention in the study was lower than expected. Recruiting and retaining this nutritionally vulnerable group of older patients was challenging, and efforts must be made to secure higher retention as well as an improved recruitment strategy.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 241-254"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-ICU nutrition challenge","authors":"Antonella Cotoia,&nbsp;Pierre Singer","doi":"10.1016/j.nutos.2025.11.004","DOIUrl":"10.1016/j.nutos.2025.11.004","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 321-322"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary inflammatory index and serum hs-CRP: A systematic review and meta-analysis","authors":"Sarah Al-Fayez ,&nbsp;Fatmah Othman ,&nbsp;Hadeel Al Bedewi ,&nbsp;Aiman El-Saed","doi":"10.1016/j.nutos.2025.11.003","DOIUrl":"10.1016/j.nutos.2025.11.003","url":null,"abstract":"<div><h3>Aim</h3><div>Chronic inflammation is a significant risk factor for the development of chronic diseases, including cardiovascular disease and diabetes. Increasing evidence explores the connection between the Dietary Inflammatory Index (DII) and inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP). However, results from individual studies are inconsistent; therefore, this study aims to assess the overall strength of the association between the DII and (hs-CRP) levels.</div></div><div><h3>Methods</h3><div>A systematic review was conducted following the PRISMA guidelines. Published observational studies investigating the relationship between DII and (hs-CRP) levels were sourced from MEDLINE and Web of Science. The primary outcome was the effectiveness of DII in predicting (hs-CRP) levels.</div></div><div><h3>Results</h3><div>The review included 19 observational studies with 65,929 participants from diverse populations. Seven studies qualified for meta-analysis. The pooled data demonstrated a significant positive association between DII scores and (hs-CRP) levels, suggesting that individuals with higher DII scores have an increased risk of elevated (hs-CRP), with a pooled OR of 1.42 [95% CI 1.31, 1.54, p &lt; 0.001, I2 = 0%]. Sensitivity analysis verified the stability of these findings.</div></div><div><h3>Conclusion</h3><div>Observational evidence indicates that DII could serve as a predictor for (hs-CRP) levels. Employing DII to assess the inflammatory potential of diets may assist in managing inflammation-related diseases through dietary modifications. Further research is recommended to identify optimal methods for evaluating DII and its links with health outcomes.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 343-356"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educational impact of a tablet application on nutrition in maintenance hemodialysis patients: A clinical pilot study","authors":"Rolf Pachlatko ,&nbsp;Patrice M. Ambühl ,&nbsp;Andreas Schleich","doi":"10.1016/j.nutos.2025.10.015","DOIUrl":"10.1016/j.nutos.2025.10.015","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate whether a novel, image-based quiz application used during dialysis sessions can improve electrolyte control and fluid balance in hemodialysis patients by enhancing dietary knowledge.</div></div><div><h3>Methods</h3><div>In this single-center, non-randomized, open-label study, 49 maintenance hemodialysis patients of our dialysis center in Zurich (Switzerland) used a tablet-based quiz application during dialysis sessions over a four-week period. Dialysis was performed three times a week with a mean duration of 230 min. The app presented visual comparisons of food items regarding sodium, potassium, and phosphate content. Primary outcomes were changes in serum potassium and phosphate; ultrafiltration volume was a secondary outcome. Learning activity was assessed based on the number and accuracy of answers. All laboratory values were collected at the beginning of the week (Monday or Tuesday) after the long interval before dialysis began. The laboratory analyses were done in the hospital laboratory.</div></div><div><h3>Results</h3><div>No statistically significant changes were observed in serum potassium (−0.038 mmol/L, <em>P</em>=0.542), phosphate (+0.083 mmol/L, <em>P</em>=0.115), or ultrafiltration volume (+67 mL, <em>P</em>=0.128). However, an increase in the proportion of correct answers (from 67.2% to 73.5%) indicated improved dietary knowledge.</div></div><div><h3>Conclusion</h3><div>Although the digital intervention led to detectable effects in training intensity and knowledge, it did not translate into improvements in electrolyte levels or fluid balance. Patient motivation and engagement intensity may influence outcomes.</div></div><div><h3>Clinical trial registration number</h3><div>NCT05111184 (<span><span>Clinicaltrials.gov</span><svg><path></path></svg></span>).</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 266-277"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145568313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility of mid-arm muscle circumference cut-offs for detecting protein-energy wasting in Malaysian hemodialysis patients","authors":"Qian-Qian Hoong ,&nbsp;Jun-Hao Lim ,&nbsp;Lee-Fang Teong ,&nbsp;Nurul Iman Hafizah Adanan ,&nbsp;Ban-Hock Khor ,&nbsp;Sharmela Sahathevan ,&nbsp;Pramod Khosla ,&nbsp;Tilakavati Karupaiah ,&nbsp;Zulfitri Azuan Mat Daud","doi":"10.1016/j.nutos.2025.09.002","DOIUrl":"10.1016/j.nutos.2025.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>Protein energy wasting (PEW) is a severe form of malnutrition prevalent among hemodialysis (HD) patients. A key diagnostic criterion outlined by the International Society of Renal Nutrition and Metabolism (ISRNM) for PEW is a reduction in mid-arm muscle circumference (MAMC) below the 50th percentile (P₅₀) of the reference population by more than 10%. However, the absence of population-specific MAMC cut-offs makes diagnosing PEW challenging. This study aimed to establish, validate and evaluate MAMC cut-offs for diagnosing PEW in Malaysian HD patients.</div></div><div><h3>Methods</h3><div>A three-phase cross-sectional study was conducted with training, validation and testing phases using a five-fold cross-validation approach against Frisancho reference. A total of 953 Malaysian HD patients were included in the analysis. Secondary data from previous Malaysian HD studies were utilized for both the training and validation phases, accounting for about 85% of the dataset. The remaining 15% of the dataset, used for the testing phase, comprised newly collected data. Data collection involved face-to-face interviews, anthropometric measurements, biochemical results, clinical data, and dietary assessments. PEW was diagnosed using the ISRNM criteria. Descriptive analysis was used to establish Malaysians HD MAMC cut-offs at P₅₀ for PEW diagnosis, as per ISRNM criteria. The area under the curve (AUC) of the receiver operating characteristics curve assessed and compared the validity of these new cut-offs against the Frisancho reference.</div></div><div><h3>Results</h3><div>The P₅₀ MAMC for Malaysian HD males was markedly lower than the Frisancho reference (24.29 cm <em>vs</em> 28.08 cm), whereas for females, it was slightly higher (23.14 cm <em>vs</em> 22.17 cm). The newly established Malaysian HD-specific MAMC cut-offs demonstrated excellent discrimination ability, outperforming Frisancho cut-offs for both validation (AUC_Malaysian = 0.904 <em>vs</em> AUC_Frisancho = 0.812) and evaluation (AUC_Malaysia = 0.871 <em>vs</em> AUC_Frisancho = 0.749).</div></div><div><h3>Conclusion</h3><div>These MAMC cut-offs serve as the first Malaysian HD-specific references, enhancing PEW diagnosis for clinical practice and future research.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 55-72"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening for malnutrition in people living with cancer and overweight or obesity: A scoping review","authors":"S. Coe ,&nbsp;T. Mitaras ,&nbsp;V. Iatridi ,&nbsp;F. Tabacchi ,&nbsp;J. Tammam ,&nbsp;E. Watson ,&nbsp;S. Wootton ,&nbsp;L. Gillespie ,&nbsp;D. Provan ,&nbsp;A. Brown ,&nbsp;N. Bibby ,&nbsp;Y.M. Goh ,&nbsp;L.J. Miller","doi":"10.1016/j.nutos.2025.10.001","DOIUrl":"10.1016/j.nutos.2025.10.001","url":null,"abstract":"<div><h3>Background</h3><div>Current approaches to malnutrition screening in cancer pathways may not identify malnutrition in people living with overweight or obesity. The review aims to identify current screening techniques and their potential validity in people living overweight or obesity and cancer.</div></div><div><h3>Methods</h3><div>PubMed, Medline and CINAHL were searched for English-language publications reporting data from malnutrition screening tools in adults with cancer living with overweight or obesity. These included 1) diagnostic accuracy studies with validity analysis against a reference, 2) comparative studies, without validity analysis, and 3) monomethod studies of single malnutrition screening tools. Registered in Open Science Framework. (<span><span>https://doi.org/10.17605/OSF.IO/ZWFBM</span><svg><path></path></svg></span>).</div></div><div><h3>Results</h3><div>3705 records were identified with 16 full-text papers included. Eleven tools and measures were used to screen for malnutrition in people living with overweight or obesity and cancer. These included questionnaires (Malnutrition Universal Screening Tool; Malnutrition Screening Tool; Patient Generated Subjective Global Assessment (original/Short Form); Nutrition Risk Screening-2002; Short Nutritional Assessment Questionnaire and its variations; Mini Nutrition Assessment-Short Form), an algorithm-based tool (Nutrition Risk Index), and handgrip strength measures.</div></div><div><h3>Discussion</h3><div>There is a lack of consensus on the most appropriate tool, though combining subjective and objective measures may improve malnutrition screening in people with cancer and overweight or obesity.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 212-229"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of omega-3 supplementation in reducing the degree of steatotic liver disease associated with metabolic dysfunction in adults","authors":"María Dolores Mondéjar Barrios ,&nbsp;Karem Justhin Rodas Trujillo ,&nbsp;Juana Olga Espíritu Aguirre ,&nbsp;Matilde Anais Matos Inga ,&nbsp;Sandra Lisseth Mori Díaz ,&nbsp;Luis Alberto Cabanillas Chirinos","doi":"10.1016/j.nutos.2025.10.011","DOIUrl":"10.1016/j.nutos.2025.10.011","url":null,"abstract":"<div><h3>Background</h3><div>Steatotic liver disease associated with metabolic dysfunction is the most common liver disease worldwide <strong>.</strong> Currently, there are no specific medications for its treatment, so it is necessary to seek options that contribute to slowing its progression and reversing it in its early stages <strong>.</strong> The objective The objective of this study was to determine the effectiveness of omega-3 supplementation in reducing the degree of steatotic liver disease associated with metabolic dysfunction in adults.</div></div><div><h3>Methods</h3><div>A quasi-experimental study with 40 participants aged 25 years and older was conducted from August 2024 to April 2025, in Trujillo, Peru. Data were collected through an interview and medical evaluation. An abdominal ultrasound was performed to confirm the diagnosis of liver disease, as well as blood transaminase tests, among others. Descriptive and inferential statistics were applied in the statistical analysis. The experimental group received omega-3 supplementation for two months; the control group was recommended a low-carbohydrate and low-fat diet. Both groups were evaluated with abdominal ultrasound at the third month.</div></div><div><h3>Results</h3><div>The relevant anthropometric parameters were abdominal obesity (95%) and overweight (55%). Statistical significance was found after supplementation (p = 0.005 &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Omega-3 supplementation at a dose of 1000 mg every 12 hours for 2 months was effective in significantly reducing the degree of steatotic liver disease associated with metabolic dysfunction in adults, showing that it is possible to obtain a favorable effect in the short term and with a lower probability of adverse effects.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 255-265"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145520153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}