Clinical Nutrition Open Science最新文献

{"title":"The relationship between prebiotic and probiotic foods consumption and the nutritional status of high school students aged 15–18: A cross- sectional study","authors":"Sayu Putu Yuni Paryati ,&nbsp;Carissa Wityadarda ,&nbsp;Nadia Amanda ,&nbsp;Mayfa Yemima S ,&nbsp;Adi Anggoro Parulian ,&nbsp;Bernadette Victoria ,&nbsp;Moch Novian Saputra ,&nbsp;Teresa Ester Sekar Kinasih ,&nbsp;Fernando Diaz Ndopo ,&nbsp;Augustinus Lahagu ,&nbsp;Lira Apriani Simbolon ,&nbsp;Nasya Salsabila Aditiyan ,&nbsp;F.X. Widiantoro","doi":"10.1016/j.nutos.2025.12.004","DOIUrl":"10.1016/j.nutos.2025.12.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Adolescence experience rapid growth and requires optimal nutrition. Prebiotics and probiotics foods contribute to gut microbiota balance, influencing digestion and nutrient absorption which manifest on the nutritional status. However, the data intake of these foods among Indonesian adolescents remains limited. This study aimed to examines the association between consumption of prebiotic and probiotic food sources and nutritional status among high school students in West java, Indonesia.</div></div><div><h3>Methods</h3><div>Design: A Cross-sectional analytic observational study.</div></div><div><h3>Setting</h3><div>SMA Negeri 2 Padalarang, West Bandung Regency, West Java, Indonesia.</div></div><div><h3>Participants</h3><div>306 students (grades X-XII) selected through stratified random sampling. All completed the study. Measurements: A food frequency questionnaire assessed intake of prebiotic and probiotic sources. Nutritional status was determined using Body mass Index (BMI) for age.</div></div><div><h3>Results</h3><div>Fermented food (<em>r</em> = −0.139, <em>p</em> = 0.015) and vegetable consumption (<em>r</em> = −0.477, <em>p</em> &lt; 0.001) were negatively associated with BMI, indicating higher intake corresponding with lower BMI. In Contrast, Cerealia (<em>r</em> = 0.165, <em>p</em> = 0.004) and chocolate products consumption (<em>r</em> = 0.388, <em>p</em> &lt; 0.001) were positively associated with BMI. Meanwhile, fruit, nut, and legumes intake showed no significant relationship. Both prebiotic and probiotic intake accounted for 35.5% of the variation in nutritional status (<em>R</em>² = 0.355).</div></div><div><h3>Conclusions</h3><div>Consumption of fermented foods and vegetables is associated with lower BMI, while cereals and chocolate products are linked to higher BMI among adolescents. Dietary patterns involving prebiotic and probiotic sources may influence adolescent nutritional status. However, other contributing factors should be considered in future interventions.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100610"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world implementation of a standardized ICU protocol for daytime-restricted enteral nutrition in critically ill adults: A retrospective quality improvement study","authors":"Kelsey Russell-Murray ,&nbsp;Hassan S. Dashti","doi":"10.1016/j.nutos.2025.100622","DOIUrl":"10.1016/j.nutos.2025.100622","url":null,"abstract":"<div><h3>Background</h3><div>Enteral nutrition (EN) delivery is often interrupted in the intensive care unit (ICU), and while continuous 24-hour feeding is standard practice, emerging evidence from circadian biology and pilot trials suggests that daytime-restricted EN may enhance nutritional adequacy and patient outcomes by aligning feeding with biological rhythms.</div></div><div><h3>Methods</h3><div>This quality improvement study describes a novel, standardized daytime-restricted EN protocol in a community hospital ICU and retrospectively evaluate its real-world implementation. The protocol involved a stepwise transition in EN delivery, beginning with continuous trophic feeding (acute/initial phase), followed by daytime-restricted 12-hour cyclic feeding (anabolic recovery phase), and advancing to intermittent daytime-restricted feeding (chronic recovery phase). A convenience sample of 22 adult ICU patients (12 received continuous 24-hour EN; 10 with the daytime-restricted EN protocol) was analyzed. Clinical data were extracted from electronic medical records, including EN infusion rates, duration, and interruptions.</div></div><div><h3>Results</h3><div>Patients in the daytime-restricted group received EN at higher infusion rates (median 87.5 vs. 40.0 mL/hr), over fewer hours per day (11.0 vs. 14.5 hours), experienced fewer interruptions (1.0 vs. 9.5 hours/day), and received a greater percentage of their prescribed nutritional volume (90.0% vs. 57.5%) compared to the continuous group (all <em>P</em> value &lt; 0.05). Vomiting was more frequently reported in the daytime-restricted group, while constipation was more common in the continuous group, though these differences were not statistically significant.</div></div><div><h3>Conclusion</h3><div>This preliminary evaluation supports the feasibility of implementing a daytime-restricted EN protocol in an adult ICU and suggests potential advantages in delivery consistency and nutritional adequacy. To support broader implementation, larger prospective studies across broader ICU populations are necessary.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100622"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145940053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel egg white-based solid oral nutritional supplement improves serum albumin and protein intake in patients on peritoneal dialysis: A prospective interventional study","authors":"Yupa Chanwikrai ,&nbsp;Kamonwan Jongsomchai ,&nbsp;Guttiga Halue ,&nbsp;Donkum Kaewboonsert ,&nbsp;Sawitree Suwannasang ,&nbsp;Wittawas Sajjapong","doi":"10.1016/j.nutos.2025.100621","DOIUrl":"10.1016/j.nutos.2025.100621","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Protein-energy wasting (PEW) is a major predictor of adverse outcomes in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Achieving the recommended dietary protein intake remains a significant clinical challenge. This study aimed to evaluate the safety and efficacy of “Egg Bite,” a novel, palatable, solid oral nutritional supplement (ONS) derived from egg white, in improving the nutritional status of CAPD patients.</div></div><div><h3>Methods</h3><div>In this prospective, single-arm interventional trial, 35 CAPD patients with serum albumin ≤ 4.0 g/dL consumed a daily supplement of “Egg Bite” (105 g/day, providing 25.7 g protein and 392 kcal) for 21 consecutive days. The primary outcome was the change in serum albumin. Secondary outcomes included changes in overall dietary intake, anthropometric measures, and key biochemical markers (renal, metabolic, and inflammatory). Assessments were performed at baseline, day 14, and day 21.</div></div><div><h3>Results</h3><div>Thirty-five of 42 enrolled patients (83%) completed the study. Daily supplementation resulted in a significant increase in mean serum albumin from 3.38 ± 0.42 g/dL at baseline to 3.48 ± 0.43 g/dL at day 21 (<em>P</em> = 0.001). Total protein intake rose significantly from 0.9 ± 0.2 g/kg/day to 1.4 ± 0.4 g/kg/day (<em>P</em> &lt; 0.001), successfully meeting guideline recommendations. Energy intake also increased significantly (<em>P</em> &lt; 0.001). No significant changes were observed in body weight or BMI. The supplement was well-tolerated, with non-significant increases in serum potassium and stable hemoglobin levels. Minor but statistically significant increases in BUN and creatinine were noted, consistent with increased protein metabolism. In patients with baseline hypoalbuminemia (n=19), hs-CRP showed a non-significant downward trend from 10.44 to 8.10 mg/dL.</div></div><div><h3>Conclusions</h3><div>Daily supplementation with “Egg Bite,” a novel egg white-based solid ONS, is a safe, well-tolerated, and effective intervention for improving protein-energy status in CAPD patients. It significantly elevates serum albumin and dietary protein intake to meet clinical targets without inducing adverse metabolic effects. “Egg Bite” represents a promising tool for managing PEW, though longer-term studies are needed to evaluate its impact on body composition and clinical outcomes.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100621"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does skeletal muscle weakness recognized early during hospitalization for acute heart failure predict short-term mortality?","authors":"Vinicius Ferigato,&nbsp;Fernanda Takeyama,&nbsp;Felipe Rocha,&nbsp;Giulio Checchinato,&nbsp;Bruna Eduarda Gandra,&nbsp;Bruno Maciel,&nbsp;Marina May Antonio,&nbsp;Beatriz Santana Silva,&nbsp;Helder Jorge A. Gomes,&nbsp;Alcides Rocha","doi":"10.1016/j.nutos.2025.12.006","DOIUrl":"10.1016/j.nutos.2025.12.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Impairment of skeletal muscle is common in heart failure (HF) but understudied in acute episodes.</div></div><div><h3>Objective</h3><div>To assess the relationship between skeletal muscle weakness identified early during hospitalization for acute HF and the risk of hospital mortality.</div></div><div><h3>Methodology</h3><div>we conducted a prospective, single center study enrolling patients ≥ 18 years old admitted from the emergency department with acute HF (March 2023–April 2024). We excluded individuals with other causes of muscle weakness, including dementia, delirium and cerebrovascular disease. In the ward, a physical educator performed handgrip tests and values &lt; 27 (men) and 16 kg (women) were used to define muscle weakness (according to EWGSOP2). In the same day, all participants underwent clinical examination by a cardiologist who assessed signs of congestion and hypoperfusion to classify patients into the 4 clinical-hemodynamic profiles established in the literature (A, B, C and L).</div></div><div><h3>Results</h3><div>The sample consisted of 37 participants, who were 68 (±15) years old (mean ± standard deviation) and predominantly men (68%). We performed the study procedures in 2 (2) days (median and interquartile range) after patients arrived at the emergency department. The handgrip tests identified 15 participants with skeletal muscle weakness (40% of the sample). This group had more severe clinical presentations of HF, with a higher proportion of participants showing both congestion and hypoperfusion signs (profile C) than the group with normal strength (47 vs 5%; <em>P</em> = 0.020). The in-hospital mortality rate was 33% in the group with muscle weakness compared to 5% in the group with normal strength (<em>P</em> = 0.031). A logistic regression model (Chi-square = 5.568; df =1; <em>P</em> = 0,018; R² = 0.238) showed muscle weakness as the only variable independently associated with hospital mortality (<em>P</em> = 0.043).</div></div><div><h3>Conclusion</h3><div>Early recognition of muscle weakness identified a group of patients with acute HF at increased risk of hospital mortality.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100612"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145814422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative validity of surrogate measures within the global leadership initiative on malnutrition (GLIM) phenotypic criteria for diagnosing adult malnutrition in resource-constrained settings","authors":"E. Van Tonder ,&nbsp;F.A.M. Wenhold ,&nbsp;T. Esterhuizen ,&nbsp;R. Blaauw","doi":"10.1016/j.nutos.2025.12.012","DOIUrl":"10.1016/j.nutos.2025.12.012","url":null,"abstract":"<div><h3>Background and aim</h3><div>Implementing the Global Leadership Initiative on Malnutrition (GLIM) diagnostic criteria may improve adult malnutrition identification. Some GLIM parameters are challenging to obtain in resource-constrained settings. We assessed the relative validity of accessible surrogates in substituting accepted phenotypic diagnostic criteria within GLIM.</div></div><div><h3>Methods</h3><div>In a prospective diagnostic accuracy study, adult ambulatory patients with diverging diagnoses from five South African hospitals were consecutively sampled. The Malnutrition Universal Screening Tool (MUST score≥1) and GLIM diagnostic criteria determined malnutrition risk and diagnosis respectively. Surrogates investigated for appendicular skeletal muscle mass index (ASMMI), measured by multifrequency bio-electrical impedance, were mid-upper arm circumference (MUAC) and body mass index-adjusted calf circumference (CC). Pearson correlation coefficients, receiver operating characteristics curve analysis, Youden's index, sensitivity (Se), specificity (Sp), and Cohen's kappa were used.</div></div><div><h3>Results</h3><div>Among 480 patients screened (51% male; mean age: 47.03 years, SD 14.87), 73% (<em>n</em> = 350) were at malnutrition risk. Of these, 54% (<em>n</em> = 189) were malnourished (GLIM criteria). MUAC and CC moderately correlated with ASMMI (<em>r</em> = 0.645; <em>P</em>&lt;0.001 and <em>r</em> = 0.515; <em>P</em>&lt;0.001 respectively). Optimal cut-offs for surrogates, with corresponding diagnostic accuracy, were: MUAC for ASMMI: 24.9 cm (area under the curve (AUC) = 0.857, Se = 85%, Sp = 74%) and CC for ASMMI: 29.1 cm (AUC = 0.819, Se = 73%, Sp = 83%). Substituting MUAC and CC for ASMMI at study-specific cut-offs - within the GLIM phenotypic criteria - was relatively valid (MUAC: kappa = 0.925, Se = 100%, Sp = 91%; CC: kappa = 0.849, Se = 100%, Sp = 91%).</div></div><div><h3>Conclusion</h3><div>Within GLIM and using the reported cut-offs, MUAC reflects ASMMI. BMI-adjusted CC can replace low skeletal muscle mass. Valid, easy-to-use surrogates may enhance the feasibility of the GLIM diagnostic framework, particularly where resources are constrained.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"65 ","pages":"Article 100618"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteral nutrition in critically ill patients with COVID-19 in mechanical ventilation and prone position: Comparison of two enteral formulas","authors":"Gómez-Alaniz Karen Ivette ,&nbsp;Pérez-Cruz Elizabeth","doi":"10.1016/j.nutos.2025.11.002","DOIUrl":"10.1016/j.nutos.2025.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Enteral nutrition in critically ill patients with SARS-Cov-2 infection and the need for mechanical ventilation in the prone position has been a challenge.</div></div><div><h3>Methods</h3><div>An ambispective cohort study. A total of 278 analyzed patients consecutively admitted to the intensive care unit (ICU) with diagnosis of SARS-COV-2 infection by RT-PCR. The patients were divided into two groups, those who received enteral formula: a) normocaloric 1 kcal/ml and b) hypercaloric 1.5 kcal/ml. The optimal nutritional intake was defined as providing &gt;70% of the total energy requirement calculated within the first 72 hours of admission to the ICU. Gastrointestinal complications were evaluated such as reflux due to aspiration, diarrhea, abdominal distension. The aim of this study was to evaluate the optimal nutritional contribution through high-caloric vs normocaloric enteral formulas.</div></div><div><h3>Results</h3><div>The energy intake was higher in the group that received hypercaloric formulas in 97.8% vs. 73.4% of the group normocaloric formulas (p &lt;0.001). Gastrointestinal complications were lower in the group that received high-calorie formulas (p &lt;0.001). Patients with &gt; 11 SOFA points had a 2.07 times greater risk of not meeting the calculated energy requirements (p &lt; 0.05). Energy requirement per kg body actual weight for each patient was 23.0 ± 3.4 kcal/Kg/d. ICU stay, and mortality were similar in both groups.</div></div><div><h3>Conclusions</h3><div>The optimal nutritional contribution was achieved with both enteral formulas. Gradually increasing from low doses to the caloric target is safe, with high-calorie formulas being better tolerated and with fewer gastrointestinal complications.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 323-331"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving aging-related frailty status among older adults: Results of a nutrition-focused program","authors":"Carlos Cano-Gutierrez ,&nbsp;Luis Carlos Venegas-Sanabria ,&nbsp;Gabriel Gomez ,&nbsp;Estephania Chacón-Valenzuela ,&nbsp;María Fernanda Dueñas ,&nbsp;Daniela Gracia ,&nbsp;Juan Diego Misas ,&nbsp;Elkin Garcia-Cifuentes ,&nbsp;Suela Sulo ,&nbsp;Leocadio Rodríguez-Mañas","doi":"10.1016/j.nutos.2025.08.010","DOIUrl":"10.1016/j.nutos.2025.08.010","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Healthcare professionals today aim to boost the years older people live in good health by reducing the impact of aging-related frailty. Toward healthier aging, our current analysis quantified frailty changes that occurred when poorly nourished, community-living, older adults received interventional nutrition care.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We recruited outpatient study participants ≥ 60 years and malnourished or at-risk on screening (Mini Nutrition Assessment-Short Form, MNA-SF). For quasi-experimental analysis, we selected those who were prefrail or frail by Fried phenotype criteria (n=524). Each followed a comprehensive nutrition-focused Quality Improvement Program (QIP)—counseling on nutrition and physical activity, daily consumption of oral nutritional supplements for 60 days (Ensure with Hydroxymethylbutyrate® and Glucerna®, Abbott, USA), with follow-up through day 90. We quantified outcomes as changes from baseline to post-intervention for (i) overall frailty status (frail, prefrail, normal) or (ii) number of positive Fried frailty criteria of five (weight loss, exhaustion, low physical activity, slow gait speed, and muscular weakness) using change categories &lt;em&gt;Worse, Same, or Better&lt;/em&gt;. We also measured baseline and post-intervention status of nutritional state (MNA-SF), mental state/cognitive status (Mini-Mental State Exam, MMSE), depression/psychological health (Geriatric Depression Scale, GDS), and disability (Barthel Index, BI). We applied logistic regression analyses to identify factors that predicted post-intervention improvement in frailty status.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;At baseline, the mean age of participants was 74.2 (±8.7) years, 71% (n=372/524) of participants were prefrail, and 29% (n=152/524) were frail; 16.2% (n=85/524) were malnourished, and 83.8% (n=439/524) were at risk. By study day 90, 34.4% (180/524) of participants had a &lt;em&gt;better&lt;/em&gt; frailty status, while 55% (n=288/524) met fewer frailty criteria. &lt;em&gt;Better&lt;/em&gt; frailty status was also associated with significantly higher MNA-SF score (12.3 vs 9.1, P &lt; 0.001), improved mental state/cognitive status as higher MMSE score (28.1 vs 27.7, P &lt; 0.05), decreased depression/improved psychological health as lower GDS score (3.3 vs 4.5, P &lt; 0.001), and greater independence as higher BI score (96.9 vs 96.1, P &lt; 0.05). Logistic regression analyses showed that MNA-SF score improvement was predictive of frailty improvement in response to the nutrition-focused QIP intervention. Specifically, individuals who experienced improvement from prefrail or frail to normal were nearly 8-times more likely than others to have a parallel increase in MNA-SF score (Odds ratio of 7.83, 95% CI 4.3–15.2, P &lt; 0.01).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Healthy aging can be supported by addressing poor nutritional status, a frailty risk contributor. We found that community-living older adults achieved a &lt;em&gt;better&lt;/em&gt; frai","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin C and L-arginine as potential synergistic adjuvants to recover intestinal mucositis induced by chemotherapy","authors":"Amanda Dias Borges ,&nbsp;Raquel Baumgratz Marques ,&nbsp;Luiz Octávio Pires ,&nbsp;Luísa Martins Trindade ,&nbsp;Nayara Salgado Vieira Sette ,&nbsp;Maria Emília Rabelo Andrade ,&nbsp;Samanta Thomas-Valdés ,&nbsp;Paola Caroline Lacerda Leocádio ,&nbsp;Jacqueline Isaura Alvarez-Leite ,&nbsp;Fernanda Rezende Souza ,&nbsp;Geovanni Dantas Cassali ,&nbsp;Ramon de Oliveira Souza ,&nbsp;Flaviano dos Santos Martins ,&nbsp;Valbert Nascimento Cardoso ,&nbsp;Simone de Vasconcelos Generoso ,&nbsp;Simone Odília Antunes Fernandes","doi":"10.1016/j.nutos.2025.10.013","DOIUrl":"10.1016/j.nutos.2025.10.013","url":null,"abstract":"<div><h3>Purpose</h3><div>Chemotherapy-induced intestinal mucositis is a debilitating condition often triggered by 5-fluorouracil (5-FU). This study investigated the effect of vitamin C alone and combined with L-arginine, in a murine model of 5-FU-induced mucositis.</div></div><div><h3>Methods</h3><div>Male BALB/c mice were divided into four groups: Control, Mucositis, Mucositis + Vitamin C, and Mucositis + Vitamin C + Arginine. Treatments were administered by gavage for 10 days, with mucositis induction on day 7. Clinical (body weight, food intake), histological, morphometric, immunological, oxidative stress, and gene expression parameters were evaluated.</div></div><div><h3>Results</h3><div>Mucositis significantly reduced weight and food intake (<em>P</em>&lt;0.05). Vitamin C alone enhanced anti-inflammatory effects more than combined with arginine, reducing lipid peroxidation and preserving intestinal structure. Both treatments maintained sIgA levels (<em>P</em>&lt;0.05). Notably, the combination with arginine had a synergistic effect on collagen synthesis (<em>P</em>&lt;0.05).</div></div><div><h3>Conclusion</h3><div>These findings suggest that vitamin C protects against mucositis, while its combination with arginine may enhance tissue regeneration via collagen production.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 377-390"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From bedside to beyond: The long-term impact of early mobilization in the ICU","authors":"Elisabetta Roberti ,&nbsp;Michele Bertoni ,&nbsp;Nicola Latronico ,&nbsp;Simone Piva","doi":"10.1016/j.nutos.2025.10.006","DOIUrl":"10.1016/j.nutos.2025.10.006","url":null,"abstract":"<div><div>Advances in critical care have substantially reduced intensive care unit (ICU) mortality; however, survivors frequently face long-lasting sequelae, including physical disability, cognitive decline, psychological disorders, and impaired health-related quality of life (HRQoL), collectively known as post-intensive care syndrome (PICS). Critical illness weakness (CIW) is a major contributor to the physical dimension of PICS and is associated with adverse short- and long-term outcomes. EM has been proposed as a key non-pharmacological intervention to mitigate CIW, preserve muscle mass and function, and improve patient recovery. Evidence consistently demonstrates that EM is feasible and generally safe in the ICU setting, and that it confers several short-term benefits, including improved functional independence, reduced duration of delirium, and fewer complications such as ventilator-associated pneumonia and venous thromboembolism. However, the impact of EM on long-term outcomes remains uncertain. Meta-analyses and smaller trials suggest that EM may improve patient-reported physical function at 6 months, but large randomized controlled trials and longer follow-up studies have not shown sustained improvements in objective measures of physical performance, cognitive outcomes, or HRQoL. Several factors may account for these discrepancies, including heterogeneity of mobilization protocols, variations in patient selection, limited continuation of rehabilitation after ICU discharge, and the complex multifactorial nature of long-term impairments. Integration of EM with optimal nutrition and multimodal rehabilitation strategies may hold greater promise, but robust evidence is lacking. Overall, while EM remains a cornerstone of ICU rehabilitation with clear short-term benefits, its long-term impact is less certain, underscoring the need for further high-quality, patient-centered research.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 170-180"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145467005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of tea in digestive tract malignancies: A two-sample Mendelian randomization study","authors":"Chen Fei Liang","doi":"10.1016/j.nutos.2025.08.012","DOIUrl":"10.1016/j.nutos.2025.08.012","url":null,"abstract":"<div><h3>Background</h3><div>There is no clear consensus on the association between tea intake and cancer, particularly its protective causal relationship with gastrointestinal tumors. This study aims to investigate this causal association using Mendelian randomization (MR) analysis to inform dietary interventions.</div></div><div><h3>Methods</h3><div>This two-sample MR study utilized summary statistics on tea consumption from genome-wide association studies (GWAS) conducted by the UK Biobank (UKB) and Biobank Japan (BBJ). Data on gastrointestinal tumors were sourced from GWAS by the FinnGen consortium and BBJ. The causal relationship was assessed using methods such as inverse variance weighted (IVW), MR-Egger, and MR-PRESSO. Horizontal pleiotropy and heterogeneity of instrumental variables (IVs) were evaluated using MR-PRESSO and Cochran's Q tests.</div></div><div><h3>Results</h3><div>IVW estimates indicated that in the Asian population, tea intake was negatively associated with colorectal cancer risk (OR=0.372, 95%CI: 0.157–0.881). In the European population, higher green tea consumption was linked to a lower risk of malignant neoplasm of the small intestine (OR=0.940, 95%CI: 0.901–0.982).</div></div><div><h3>Conclusions</h3><div>Tea intake may have a causal association with a reduced risk of colorectal cancer, offering new insights for its prevention. Further studies are needed to explore the specific protective mechanisms of tea consumption on gastrointestinal tumors.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"64 ","pages":"Pages 39-54"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}