Clinical Nutrition Open Science最新文献

{"title":"Association of gene methylation status RLEP, LEP, FTO, BDNF and COMT with risk factors for eating disorders in Mexican university students","authors":"R.G. Garfias-Guzmán ,&nbsp;M. de Lorena Ramos-García ,&nbsp;C. Castro-Hernández ,&nbsp;L. Casas-Ávila ,&nbsp;O.C. Martínez-Ramírez","doi":"10.1016/j.nutos.2025.06.004","DOIUrl":"10.1016/j.nutos.2025.06.004","url":null,"abstract":"<div><div>Eating Disorders are complex conditions characterized by negatively impact a person's physical and mental health. Risky eating behavior are closely related to risk factors such as BMI, sex, depression, and anxiety.</div></div><div><h3>Aim</h3><div>The objective of this study is to determine the association of gene methylation status RLEP, LEP, FTO, BDNF, and COMT with the risk factors for eating disorders in Mexican university students.</div></div><div><h3>Methods</h3><div>An analytical cross-sectional study was carried out. Data on risky eating behavior, anxiety, and depression were collected using self-applicable questionnaires EAT, BAI, and BECK, respectively. The methylation of the genes was determined by MSP-PCR.</div></div><div><h3>Results</h3><div>We included 83 individuals, 61.4% women, and 38.6% men. Our results showed an association between the risk of eating disorders and anxiety and/or depression. When we determine the interaction between genes and risk factors, we find that the greater the number of risk variables, the greater the association of presenting risky eating behavior in Mexican university students.</div></div><div><h3>Conclusion</h3><div>We found an association between risk factors, especially depression and anxiety, with risky eating behavior in Mexican university students.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"63 ","pages":"Pages 79-90"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health assessment of 4–13 years students living in a rural Andean region: The EVANES study design protocol","authors":"Fátima Morales ,&nbsp;Marcela Guerendiain","doi":"10.1016/j.nutos.2025.06.003","DOIUrl":"10.1016/j.nutos.2025.06.003","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>In Ecuador, stunting and overweight are the main nutritional problems identified at school age in the indigenous population, associated with infectious diseases and diarrhoea. The Andean region has the largest indigenous population in the country, which suffers from inequality and poverty, especially those inhabiting rural areas. Clinical studies have shown a high infection vulnerability of rural populations. Therefore, we aim to evaluate nutritional status according to dietary intake, intestinal parasitic infections, household and environmental conditions, ant their relation with cognitive development of schoolchildren in rural highlands of Ecuador in order to develop prevention and health promotion programmes adapted to the needs of these children and their families.</div></div><div><h3>Methods</h3><div>The EVANES study is a multi- and interdisciplinary approach designed to evaluate the dietary intake, anthropometric parameters, intestinal parasitic infections, hygienic-sanitary and environmental conditions and cognitive development of Ecuadorian schoolchildren.</div></div><div><h3>Results</h3><div>This exhaustive assessment may be useful for: identifying nutritional issues, establishing health programmes for disease prevention and health promotion, clarifying the aetiology of stunting in the indigenous population, and defining reference patterns for the diagnosis of anaemia in the highlands in childhood.</div></div><div><h3>Conclusions</h3><div>The EVANES study could be a model protocol for other areas of Ecuador and countries, and can contribute to improving the health and development of children in Latin American and highland countries. It is expected to contribute to the scientific community with unique insights into the health status of rural indigenous schoolchildren living at high altitude, in order to develop appropriate health programmes and policies for disease prevention and health promotion in these populations.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 189-207"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of ultra-processed foods on the gut microbiome and gastrointestinal complaints after bariatric surgery: A narrative review","authors":"Hendrika J.M. Smelt ,&nbsp;Sjaak Pouwels ,&nbsp;Christine Stier ,&nbsp;Johannes F. Smulders","doi":"10.1016/j.nutos.2025.06.005","DOIUrl":"10.1016/j.nutos.2025.06.005","url":null,"abstract":"<div><h3>Background</h3><div>Bariatric surgery (BS) leads to malabsorption trough alterations of the gastrointestinal tract, which can result in changes in the gut microbiome (GM). Disturbances in the GM are associated with disruptions in nutrient digestion and absorption, regulation of intestinal motility, and maintenance of intestinal epithelium integrity. GM diversity significantly changes after BS but is not fully restored.</div></div><div><h3>Goal of this review</h3><div>A significant number of patients also experience chronic, unexplained abdominal complaints. It is presumed that food intake may play a more substantial role than previously thought. This review provides an overview of the (nutritional) factors that may contribute to abdominal pain after bariatric surgery.</div></div><div><h3>Conclusion</h3><div>Worldwide, many ultra-processed foods are consumed, which disrupt the GM and likely contribute to gastrointestinal symptoms and exacerbate the chronic inflammatory process. However, the influence of these products on the development of gastrointestinal complaints after BS has not yet been studied. This should be the focus for future research.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 208-217"},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional management of survivors of critical illness: The clinical pharmacists' role","authors":"Zenzi Rosseel ,&nbsp;Stephanie C.M. Wuyts ,&nbsp;Marjoleine Desmedt ,&nbsp;Sandrina von Winckelmann ,&nbsp;Elisabeth De Waele ,&nbsp;Claudine Ligneel ,&nbsp;Pieter-Jan Cortoos","doi":"10.1016/j.nutos.2025.06.002","DOIUrl":"10.1016/j.nutos.2025.06.002","url":null,"abstract":"<div><div>Critically ill patients face many challenges such as dysphagia leading to muscle loss and malnutrition. To prevent and treat malnutrition, ICU protocols from the European Society of Clinical Nutrition and Metabolism (ESPEN) and American Society of Parenteral and Enteral Nutrition (ASPEN) are established, available and implemented in ICU's, However, in the post-ICU phase, little literature is available evaluating the nutritional needs of those patients as well as the challenges they are facing. Artificial nutrition can be used to provide adequate nutrition, but in combination with various drugs such as prokinetics or analgesics drug side effects, drug-drug and drug-nutrition interactions may occur resulting in suboptimal nutritional therapy. To prevent these problems, clinical pharmacists can provide meaningful support. Clinical pharmacists are specialists in medication review and medication reconciliation guaranteeing adequate dosing, preventing side effects and checking for drug appropriateness. Through multidisciplinary collaboration, they are also often involved in nutritional support. The aim of this article was to review current literature regarding the roles of clinical pharmacists as well as providing insights in their future role in post-ICU nutritional care.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 127-138"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144290755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary biomarkers of ultra-processed foods: A narrative review","authors":"Thomas Scott Armstrong,&nbsp;Kaitlyn Delaney Chappell,&nbsp;Lekan Ajibulu,&nbsp;Karen Wong","doi":"10.1016/j.nutos.2025.06.001","DOIUrl":"10.1016/j.nutos.2025.06.001","url":null,"abstract":"<div><div>The rapidly increasing prevalence of ultra-processed foods (UPFs) in global diets necessitates a more comprehensive understanding of this food group's effects on health and disease. Nutritional biomarkers are critical for developing this understanding, as they provide an objective assessment of the body's response to UPF intake. Here, we critically assessed the findings of five studies-all of which were identified via a systematic search of the literature using stringent criteria and were focused on the biomarkers of UPFs. Based on the data extracted, we categorized UPF biomarkers into organic acids (including amino acids), lipids/lipid-like molecules, xenobiotic food components (specifically associated with UPFs), and other molecular compounds (dietary oxysterols, nucleotides, proteins, etc). These findings emphasized the importance of future studies concerning UPF and food processing techniques, while providing a succinct summary of the current biomarkers of UPFs in relevant literature.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 156-163"},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of nutrition in various endocrine and metabolic diseases","authors":"Nanny Natalia Mulyani Soetedjo","doi":"10.1016/j.nutos.2025.05.015","DOIUrl":"10.1016/j.nutos.2025.05.015","url":null,"abstract":"<div><div>The endocrine system plays a central role in maintaining the body's homeostasis. Endocrine and metabolic disorders are complex and critical areas of healthcare, given their crucial role in regulating various body functions. The author presents nutritional therapy recommendations that can play an essential role in the management of endocrine and metabolic disorders, namely panhypopituitarism, adrenal fatigue, osteoporosis, obesity, dyslipidemia, hyperuricemia, aging, menopause and andropause, thyroid disorders, and diabetes, to provide a holistic understanding of the role of nutrition and improve the quality of life of patients with these conditions.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 164-188"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144338268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between dietary fat intake and benign breast diseases: a systematic review","authors":"Amir Hossein Faghfouri ,&nbsp;Fatemeh Azizi-Soleiman ,&nbsp;Sevda Saleh-Ghadimi ,&nbsp;Hamed Jafari-Vayghan","doi":"10.1016/j.nutos.2025.05.014","DOIUrl":"10.1016/j.nutos.2025.05.014","url":null,"abstract":"<div><div>Benign breast diseases (BBDs) may herald breast cancer, and diet is one of the most important environmental factors associated with both conditions. Dietary fat intake has been suggested as a potential risk factor for BBDs. We performed a systematic review to comprehensively scrutinize the current knowledge regarding the relationship between dietary fat intake (DFI), the types of consumed fats, and BBDs. A deep and meticulous search was conducted to gather relevant publications until 30th December 2023. The search was conducted in the following databases: PubMed/Medline, Web of Science, Embase, and Scopus. Eligible studies included female participants with BBDs, employed cross-sectional, case-control, or cohort designs, assessed dietary fat intake using validated tools, and reported outcomes as odds ratios, relative risk, or hazard ratios. After screening, a total of nine studies were included in our final review. The data required were extracted, and the risk of bias was assessed. Our systematic review found that the consumption of vegetable fat could be protective against BBDs while the consumption of animal fat and monounsaturated fat was associated with a higher risk of BBDs. No significant relationship was found between the intake of saturated and polyunsaturated fats and BBDs. A robust relationship between the consumption of various types of dietary fats and BBDs could not be elucidated based on available evidence. Nevertheless, it is advisable for patients who are at risk of BBDs to follow healthy eating habits and be vigilant about the excessive consumption of fats and oils.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 102-113"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between reduced lung function, hydration and nutritional status in patients on hemodialysis: An observational study using bioelectrical impedance vector analysis (BIVA)","authors":"Sheila Borges ,&nbsp;Angela Teodósio da Silva ,&nbsp;Taís Ferreira Martins ,&nbsp;Letícia de Araújo Morais ,&nbsp;Felipe Vilaça Cavallari Machado ,&nbsp;Gerson Cipriano Júnior ,&nbsp;Graziella França Bernardelli Cipriano","doi":"10.1016/j.nutos.2025.05.012","DOIUrl":"10.1016/j.nutos.2025.05.012","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>This study aimed to determine the lung function and to investigate the association between pulmonary parameters, hydration, and nutritional status – assessed by bioelectrical impedance vector analysis (BIVA) – in patients on HD.</div></div><div><h3>Methods</h3><div>A cross-sectional study, including patients with CKD on HD, age &gt;18 years. Laboratory data, lung function and body composition by bioimpedance were evaluated.</div></div><div><h3>Results</h3><div>The sample consisted of 42 participants, 23 (55%) male and age 54±14 years. Reduced lung function was prevalent in 30 (71%) participants, and compared to those with preserved lung function, they had higher dialysis vintage, lower body weight, body mass index, adipose tissue mass and fat tissue. Regarding hydration status and bioimpedance parameters, participants with reduced lung function had significant difference in the variable overhydration (OH) (<em>P</em> = 0.034). OH, phase angle (PhA) and reactance (Xc) correlated with forced vital capacity (FVC) and forced expiratory volume in 1^st second (FEV₁). Regarding BIVA, the mean vector of patients with reduced lung function indicated hyperhydration and malnutrition and the mean vector of preserved lung function indicated normohydration and adequate nutritional status. The multivariate logistic regression analysis to determine predictors of reduced lung function showed that OH was significantly associated with this condition.</div></div><div><h3>Conclusions</h3><div>Participants with reduced lung function had lower weight, body mass index, fat tissue and hyperhydration, consequently, bioimpedance parameters (OH, PhA and Xc) were correlated with respiratory variables. Fluid status was a predictor of reduced lung function in patients on HD.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 114-126"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative treatment with octreotide in patients with gastroesophageal cancer: An open-label phase 2 study","authors":"Anders Holmén ,&nbsp;Maria Lampi ,&nbsp;Ioannis Rouvelas ,&nbsp;Berit Sunde ,&nbsp;Thorhallur Agustsson ,&nbsp;Greger Lindberg ,&nbsp;Fredrik Klevebro","doi":"10.1016/j.nutos.2025.05.009","DOIUrl":"10.1016/j.nutos.2025.05.009","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Dietary peptides are hypothesized to contribute to persistent weight loss following gastrectomy or esophagectomy in cancer patients. Previous studies have suggested that this effect might be partially mitigated by Octreotide. This study aimed to evaluate the safety and tolerability of intramuscular Sandostatin® (Octreotide Long-Acting Release [LAR] depot 10mg) focusing on the incidence and characterization of adverse events.</div></div><div><h3>Methods</h3><div>A prospective open-label phase-2 study was conducted from September 2021 to October 2023. Twenty patients (10 undergoing gastrectomy and 10 undergoing esophagectomy) were enrolled. Each patient received three doses of intramuscular Sandostatin® LAR depot 10mg at 7 days, 1 month, and 2 months post-surgery. All patients were evaluated at 7 days and at 1-, 2-, 3-, and 6-months post-surgery.</div><div>The primary endpoint was safety, assessed by the incidence and characterization of adverse events, with no occurrence of serious adverse events defined as successful. Tolerability was defined as at the completion of the treatment protocol by at least 90% of patients.</div><div>Secondary endpoints included weight loss (percentage from baseline), Health-Related Quality of Life (assessed by the European Organisation for Research and Treatment of Cancer Core Quality of life Questionnaire [EORTC-QLQ-C30] and Quality of life Questionnaire for Oesophago-Gastric symptoms [EORTC-QLQ-OG25]) at baseline and at 1-, 2-, 3-, and 6-months post-surgery, and the proportion of patients requiring enteral nutrition via jejunostomy.</div></div><div><h3>Results</h3><div>The study was completed by 95% of participants. Serious adverse events were observed but were not attributed to the Octreotide treatment. Median weight loss at 6 months was 11% (3 months: 7%, 2 months: 4%, 1 month: 5%). Mean Global Quality of Life, as assessed by the of EORTC-QLQ-C30, declined at 1 month after surgery but promptly recovered to align with the baseline level (67.6 at baseline vs. 67.2 at 6 months). Among patients undergone esophagectomy, the percentage of patients requiring enteral nutrition was 80%, 60%, and 30% at 1-, 2-, and 3-months, respectively.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that Octreotide treatment was well tolerated and safe, with no serious adverse events attributed to the Octreotide treatment. Observed weight loss, Health-Related Quality of Life, and the proportion of patients requiring enteral nutrition aligned with expectations. Future studies should consider a double-blinded randomized controlled design preferably with a dose-response assessment to enable a more robust investigation.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"63 ","pages":"Pages 30-43"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of protein intake distribution across meals in maintenance of physical performance and muscle strength in older adults: An exploratory study based on secondary data analysis of the PRevention Of Malnutrition In Senior Subjects in the EU (PROMISS) trial","authors":"Hanneke A.H. Wijnhoven ,&nbsp;Riikka T. Niskanen ,&nbsp;Ilse Reinders ,&nbsp;Merja H. Suominen ,&nbsp;Satu K. Jyväkorpi ,&nbsp;Ingeborg A. Brouwer ,&nbsp;Margreet R. Olthof ,&nbsp;Marjolein Visser","doi":"10.1016/j.nutos.2025.05.008","DOIUrl":"10.1016/j.nutos.2025.05.008","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>There is increasing interest in the impact of protein intake distribution across meals on muscle health and physical performance in older adults, but previous studies have yielded conflicting results. This study aimed to explore the role of protein intake distribution across meals in maintenance of physical performance and muscle strength in older adults with an habitual low protein intake before and during a protein intervention trial.</div></div><div><h3>Methods</h3><div>Secondary data analysis was performed using data of the 6-month PRevention Of Malnutrition In Senior Subjects in the EU (PROMISS) trial, which focussed on increasing protein intake among community older adults (n=276) with habitual low (&lt;1.0 g/adjusted body weight/d) protein intake. Dietary intake was assessed by 3-day food diaries combined with three 24-hour dietary recalls. We examined the association between protein intake distribution and 400-m walk time and leg extension strength, including cross-sectional associations at baseline and longitudinal associations over six months. The three parameters examined included the number of meals high (≥35 g) in protein, protein distribution across meals assessed by the coefficient of variation, and the percentage of protein intake from breakfast. Additionally, we examined whether these longitudinal associations were modified by the intervention to increase protein intake.</div></div><div><h3>Results</h3><div>None of the protein intake distribution parameters were associated with 400-m walk time or leg extension strength, neither cross-sectionally nor longitudinally, except for the cross-sectional association between a higher percentage of protein intake from breakfast and slower walking pace in women only (b = 1.8 (95% CI 0.1–3.6)). Longitudinal associations were not modified by the protein intervention.</div></div><div><h3>Conclusion</h3><div>Distribution of protein intake across meals does not seem to play an important role in maintaining physical performance or muscle strength in older adults with an habitual low protein intake, even if protein intake is increased.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"62 ","pages":"Pages 89-101"},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}