Clinical Nutrition Open Science最新文献

{"title":"The effect of resveratrol on the viability of rat bone marrow mesenchymal stem cells","authors":"Fatemeh Ghasemi ,&nbsp;RozaSadat RezaTofighi ,&nbsp;Mohammad Moradiani Moradabadi ,&nbsp;Mona Zamanpour ,&nbsp;Michael Aghcheli ,&nbsp;Mohammad Amin Ebrahimi ,&nbsp;Ali Khatib ,&nbsp;Fatemeh Ashabi","doi":"10.1016/j.nutos.2024.10.017","DOIUrl":"10.1016/j.nutos.2024.10.017","url":null,"abstract":"<div><h3>Background and aim</h3><div>Resveratrol is a plant polyphenol that has antioxidant properties. In this research, in order to better understand the role of resveratrol on bone, the effect of different doses of resveratrol on the viability, proliferation, differentiation and biochemical factors of rat bone marrow mesenchyme stem cells (MSCs) was investigated.</div></div><div><h3>Methods</h3><div>To evaluate the ability of proliferation and differentiation, the MSCs were cultured up to three passages and were placed in culture media without osteogenic stimulation. At first to investigation the proliferation ability, the viability was evaluated by MTT test and trypan blue staining with 7.5, 15 and 30 mg/L treatment doses after 12, 24 and 36 hours. Then, to investigation the differentiation ability, the effect of 7.5, 15, and 30 mg/L treatment doses was assessed on the viability, electrolyte levels, and the activity of LDH, AST, ALP and ALT enzymes in differentiated cells after 5, 10, 15, and 21 days. To investigation the differentiation ability, the effect of 7.5, 15, and 30 mg/L treatment doses was assessed on the viability, electrolyte levels, and the activity of Lactate dehydrogenase (LDH), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP) and alanine aminotransferase (ALT) enzymes in differentiated cells after 5, 10, 15, and 21 days. The data were analyzed by ANOVA and Tukey's test, and p&lt;0.05 was considered as a significant level.</div></div><div><h3>Results</h3><div>The obtained results showed that in mesenchyme cells, the level of viability does not change in low dose of resveratrol, however increase in the time followed by decrease in the activity of metabolic enzymes (ALP, ALT and AST P&lt;0.5) and subsequently viability (p&lt;0.05), and this trend was reversed with increasing resveratrol concentration (significant differences among 5 days and others).</div></div><div><h3>Conclusion</h3><div>The effect of resveratrol depends on the type of cell and the treatment conditions, so it was shown in this study that the sensitivity of mesenchymal cells is higher than that of osteoblast cells. In addition, high doses of resveratrol had a positive effect on bone differentiation, so high doses of resveratrol can have a beneficial role on the health of mesenchymal cells and their differentiation into osteoblasts.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 337-347"},"PeriodicalIF":0.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling mortality predictors: Exploring phase angle as a prognostic indicator in adult and elderly patients on home enteral nutrition in curitiba","authors":"Paola Pasini Vicenski ,&nbsp;Janaina Bach Naslowski ,&nbsp;Estela Iraci Rabito ,&nbsp;Maria Cristina Gonzalez ,&nbsp;Maria Eliana Madalozzo Schieferdecker","doi":"10.1016/j.nutos.2024.10.012","DOIUrl":"10.1016/j.nutos.2024.10.012","url":null,"abstract":"<div><h3>Background and Aims</h3><div>This study investigated the Standardized Phase Angle (SPA) as a prognostic indicator of mortality among individuals undergoing Home Enteral Nutrition (HEN).</div></div><div><h3>Methods</h3><div>We conducted an observational, analytical, longitudinal study involving 108 HEN participants. Body composition was assessed using bioelectrical impedance analysis, with reactance and resistance values utilized to estimate PA. Following adjustments for age and sex, SPA was derived. Clinical outcomes such as recurrence or death were ascertained by contacting patients or caregivers via telephone 90 days post initial home visit. We examined the association between SPA, disease, and mortality outcome.</div></div><div><h3>Results</h3><div>The majority of patients were elderly, with a mean age of 68.8 years, predominantly male (56.5%), and afflicted with neurological diseases (70.4%). SPA yielded a negative value in 88.9% of the sample. A high SPA value indicated greater protection (OR 0.50, CI 0.28–0.89, <em>P</em> = 0.0181). Males exhibited lower SPA values compared to females (-2.9 vs. -1.8, <em>P</em> &lt; 0.0001). Patients with cancer had a 492% higher likelihood of mortality compared to those with neurological diseases (OR 5.92, CI 1.23–28.46, <em>P</em> = 0.0263). The ROC curve demonstrated that the optimal SPA cutoff for identifying mortality risk was -2.6°.</div></div><div><h3>Conclusions</h3><div>SPA has emerged as a predictive tool for mortality in patients with HEN. SPA can be used as a complementary tool in the general nutritional assessment of this population.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 326-336"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and feasibility of an exclusive enteral formula unprocessed and minimally processed foods added with yam flour (Dioscorea cayenensis)","authors":"Sandy Ferreira Martins ,&nbsp;Maria Tatiana Ferreira dos Santos ,&nbsp;Talita Silveira Queiroga ,&nbsp;Andrei Felipe Loureiro do Monte Guedes ,&nbsp;Ana Luiza Mattos Braga ,&nbsp;Cinthia Karla Rodrigues do Monte Guedes ,&nbsp;Maria da Conceição Rodrigues Gonçalves","doi":"10.1016/j.nutos.2024.10.016","DOIUrl":"10.1016/j.nutos.2024.10.016","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background and Aims&lt;/h3&gt;&lt;div&gt;Homemade enteral formulas have been resurfacing with a view to offering a diet free of additives and composed of fresh foods for therapeutic use for the population using enteral diets. Prioritizing healthy food groups and including natural complements, such as yam flour, is a strategy that aims to guarantee nutritional support while preserving the particular technological properties of foods delivered via probe. Therefore, this study aimed to develop an exclusive homemade enteral formula with fresh and minimally processed foods, added with yam flour (&lt;em&gt;Dioscorea cayenensis&lt;/em&gt;), according to the NOVA classification system; evaluate its nutritional, physicochemical, microbiological, rheological and osmolar characteristics, in addition to the production feasibility study.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;All raw materials used for the homemade enteral formula belong to group 1 or 2 of the NOVA classification system. An energy value of 1550 kcal/day was defined for the diet formula, with a distribution of 45% carbohydrate, 20% protein, 35% lipids and 30g fiber. Analyzes were carried out in triplicate for osmolarity, water activity, viscosity, physical stability observed after 24 hours under refrigeration, fluidity along the probe path and drip verification using the gravitational method (mL/minute). Energy density was calculated according to the calories provided by the diet and expressed in Kcal/mL. Microbiological analyzes were performed in accordance with American Public Health Association standards and formula cost was obtained.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The formula had a density of 0.64kcal/mL and osmolality of 248.92 mOsm/kg, being hypocaloric, hyperproteic and normolipidic. There was no microbial growth during the 24 hours of analysis. It showed pseudoplastic behavior (n=0.5), being approximately five times more viscous at rest (1543.3 mPa∗s) than in probe flow (30.1 mPa∗s). For thixotropy, a value (119 mPa∗s) was obtained. It is considered stable and homogeneous after refrigeration for 24 hours, with adequate fluidity and an average drip of 86±3.05 drops/min. The rheological characteristics were enhanced due to the presence of yam nutrients, including starch, non-starchy polysaccharides, glycoproteins, and dietary fiber, which provide the formula with an optimal consistency for enteral administration. It presented reduced cost (77.09%, 79.57% and 80.87%) when compared to three standard commercial formulas.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;The NIEF proposal in this study is unprecedented in that it favors a healthier dietary pattern, according to the NOVA food classification system, for the vulnerable population that needs to use enteral nutrition. The formula presented adequate nutritional, physicochemical, microbiological and rheological parameters, in addition to its low cost, which makes the use of the proposed formula viable in patients undergoing enteral nutritional therapy.","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 316-325"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142652875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicological and histopathological effects of sodium benzoate used in commercially available fruit juice on liver and kidney tissue in mice model","authors":"Dina Akter ,&nbsp;Md Meskatul Islam ,&nbsp;Md Imam Hossain ,&nbsp;Md Esrafil ,&nbsp;Bishnu Pada Dey ,&nbsp;Luthfunnesa Bari ,&nbsp;Md Abu Zubair","doi":"10.1016/j.nutos.2024.10.015","DOIUrl":"10.1016/j.nutos.2024.10.015","url":null,"abstract":"<div><h3>Aim</h3><div>This study was designed to explore the toxic effects of SB overuse on blood biochemical and histopathological changes in mice.</div></div><div><h3>Methods</h3><div>A total of sixty four (64) male swiss albino mice were divided into 08 (eight) groups. Group-1 was control that caring with normal standard diet and water, whereas mice in group-2, 3 and 4 were treated with market juice-1, 2, and 3. Group-5, 6 and 7 were treated with lab made juice-1, 2, and 3. Group-8 was treated just with SB and water.</div></div><div><h3>Results</h3><div>Higher level of glucose was found mainly in the market juice in Group-4 and Group-2. ALT, AST and ALP also the showed higher level of activity, which indicates generally in liver dysfunction. In case of AST activity, in the market treated juice group as group-2, 3, and 4 showed the higher level as compared to control group. However in the lab juice, elevated level of AST also estimated in the group-5, 6, and 7 respectively. ALP, another important enzyme in biochemical study, showed significant alterations in activity level in the treatment groups. Highest ALP level was found in group-6 and group-4. Level of creatinine was measured to observe change in the kidney. When studying this parameter, it was noted that, mice in group-8 showed highest levels of serum creatinine, which was also followed by group-4. Another biochemical parameter, bilirubin showed variations in the level in different treatment groups in this study. Bilirubin level was increased remarkably in the market juice treated group-3 and in the lab juice treated group-7. The groups showed significant alteration in histopathology of liver and kidney.</div></div><div><h3>Conclusion</h3><div>It can be concluded from the study that, excessive consumption of the market juices can have adverse effects on mice blood serum activity and organ function.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 302-315"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding previously published article","authors":"","doi":"10.1016/j.nutos.2024.08.005","DOIUrl":"10.1016/j.nutos.2024.08.005","url":null,"abstract":"","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Page 239"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of bioelectrical impedance phase angle in mice: Comparison between young and old mice","authors":"Nobuto Nakanishi,&nbsp;Nagato Katsura,&nbsp;Jun Sugiyama,&nbsp;Joji Kotani","doi":"10.1016/j.nutos.2024.10.011","DOIUrl":"10.1016/j.nutos.2024.10.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Phase angle is an important parameter for assessing tissue quality. Bioelectrical impedance analysis (BIA) is used to assess phase angle in human subjects, but its application in mice is scarcely reported.</div></div><div><h3>Methods</h3><div>A commercially available BIA device (InBody M20, InBody, Korea) was used in this study. Needles were inserted subcutaneously for measurements under inhaled anesthesia. The phase angle at 50 kH was used for comparison. First, the measurements were conducted in different electrode positions (proximal or distal) and different time series during anesthesia or after euthanasia. Second, we compared the phase angle, body weight, grip strength, and tibialis anterior muscle cross-sectional area between young (12 weeks) and old (approximately 2 years) male C57BL/6J mice.</div></div><div><h3>Result</h3><div>The phase angle was different in the proximal or distal position of the electrode (<em>p</em> = 0.02). Although the phase angle changed after euthanasia, it was not different during anesthesia (<em>p</em> = 0.39–84). Under distal electrode position and anesthesia, the body weight and cross-sectional area of the right anterior muscle were higher in old mice than in young mice (young vs. old, body weight: 24.4 ± 1.0 g vs. 33.2 ± 3.4 g, <em>p</em> &lt; 0.01; cross-sectional area: 723 ± 365 μm² vs. 977 ± 398 μm², <em>p</em> &lt; 0.01), but grip strength was lower in old mice (14.6 ± 1.3 g vs. 12.7 ± 1.8 g, <em>p</em> = 0.02). The phase angle was lower in old mice than in young mice (11.5 ± 0.9 vs. 10.2 ± 1.2, <em>p</em> &lt; 0.02).</div></div><div><h3>Conclusion</h3><div>BIA measurement in mice was feasible and reproducible, and the low phase angle was associated with reduced muscle strength.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 265-274"},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of a chest radiograph-based deep learning model to identify an imaging biomarker for malnutrition in older adults","authors":"Ryo Sasaki ,&nbsp;Yasuhiko Nakao ,&nbsp;Fumihiro Mawatari ,&nbsp;Takahito Nishihara ,&nbsp;Masafumi Haraguchi ,&nbsp;Masanori Fukushima ,&nbsp;Ryu Sasaki ,&nbsp;Satoshi Miuma ,&nbsp;Hisamitsu Miyaaki ,&nbsp;Kazuhiko Nakao","doi":"10.1016/j.nutos.2024.10.010","DOIUrl":"10.1016/j.nutos.2024.10.010","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>In recent years, artificial intelligence (AI) models based on chest radiography have gained attention in various fields, including cardiac function, age estimation, and clinical assessment during hospitalization. The Global Leadership Initiative on Malnutrition (GLIM) criteria are widely used in malnutrition diagnosis. The objective of this study is to examine the predictive ability of chest radiographs using deep learning techniques in relation to hematological parameters that are already known to be associated with malnutrition, as well as malnutrition scores, including GLIM criteria.</div></div><div><h3>Methods</h3><div>A total of 3701 older patients (age ≥65 years) were admitted to our hospital from January 2021 to January 2022, and after excluding those with missing data, participants (N=2862) were enrolled. Chest Radiographs, Basic information (height, weight, age, and sex), hematological parameters (albumin, hemoglobin, lymphocyte count, and C-reactive protein), malnutritional assessments: GLIM severity, Geriatric Nutritional Risk Index (GNRI), modified Controlling Nutritional status (mCONUT), and Subjective Global Assessment (SGA), and Nutritional Support Team (NST) intervention were extracted and utilized as training and validation data. We used chest radiographic image's matrix as explanatory variables for numerical (hematological parameters) or categorical (scoring) nutritional data as objective variables. A previously reported deep learning model helped construct a chest radiography-based prediction model from the training data. The predicted data were evaluated by computing the correlation coefficients and area under the curve (AUC).</div></div><div><h3>Results</h3><div>As a numerical variables analysis, albumin and hemoglobin predictions were relatively accurate (R=0.71, 0.74). As a categorical malnutritional prediction, chest radiograph-based AI effectively aided nutritional decisions based on GNRI (AUC: 0.88, 0.83, 0.88, and 0.90), SGA (0.75, 0.71, and 0.88), mCONUT (0.84, 0.88, 0.90, and 0.88), and GLIM severity (0.88, 0.82, and 0.85) class indices. The Class activation maps (CAM) analysis identified variation in the X-ray sites for each malnutritional AI prediction, with some sites in agreement and others in disagreement.</div></div><div><h3>Conclusion</h3><div>Deep learning-based chest radiographic AI has the potential to more accurately reflect malnutrition scoring than hematologic parameters. Furthermore, it can predict outcomes and assess malnutrition, including GLIM criteria. It is anticipated that AI will be integrated into the NST workflow in the future.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 240-251"},"PeriodicalIF":0.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional assessment in patients with chronic liver disease – Current accessibility and implementation","authors":"Daphne Bot ,&nbsp;Maarten E. Tushuizen ,&nbsp;Bart van Hoek","doi":"10.1016/j.nutos.2024.10.008","DOIUrl":"10.1016/j.nutos.2024.10.008","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Poor body composition is associated with impaired outcomes in patients with chronic liver disease (CLD), and various assessment tools are used. The aim of this study is to gain insight into the clinical practice of nutritional assessment in patients with CLD.</div></div><div><h3>Methods</h3><div>A semi-structured online survey on nutritional assessment tools for measuring body composition in patients with CLD was conducted among hepatologists and dietitians, mainly from hospitals between April 2023 and May 2023.</div></div><div><h3>Results</h3><div>A total of 45 eligible surveys were included in this study (dieticians N=35, hepatologists N=10). All dieticians had at least one nutritional assessment tool available. Bio-electrical impedance and hand-grip strength were the most available and used. The most important reasons for assessment were diagnosis of nutritional status, evaluation of nutritional intervention and for assessing risk of mortality. A proportion of 49% of the dieticians and 60% of the hepatologists respectively were familiar with the ‘European society of parenteral and enteral nutrition Guideline Clinical Nutrition in Liver disease’. Only 13% of dieticians and 60% of the hepatologists knew the ‘European Association for the Study of the Liver Clinical Practice Guidelines on nutrition in chronic liver disease’ and only eight dieticians and one hepatologist used a protocol for nutritional assessment in patients with CLD.</div></div><div><h3>Conclusion</h3><div>The importance of measuring body composition in patients with CLD for diagnosing and monitoring nutritional status and for assessing risk of mortality is well-known by dieticians and most hepatologists. However, implementation of the current guidelines is substandard and should be improved.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 206-214"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 infection induces human milk antibodies capable of mediating multiple functional activities","authors":"Jared Sheehan ,&nbsp;Aline Andres ,&nbsp;Laxmi Yeruva ,&nbsp;Alistair J. Ramsay","doi":"10.1016/j.nutos.2024.10.009","DOIUrl":"10.1016/j.nutos.2024.10.009","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Passive transfer of antibodies through breastfeeding is a potential mode of protection for newborns and infants following maternal SARS-CoV-2 infection. The primary goal of this study was to evaluate and characterize SARS-CoV-2 Spike (S)-specific antibodies in human milk samples collected longitudinally from a cohort of convalescent mothers.</div></div><div><h3>Methods</h3><div>SARS-CoV-2 infected participants enrolled in this study were lactating women aged 29–36 years with a confirmed COVID-19 diagnosis who donated milk samples at intervals over the six-month study period. Samples were evaluated for antibody subclass SARS-Cov-2 S glycoprotein binding activity by ELISA, and for the capacity of antibodies purified from these samples to mediate neutralizing antibody (nAb) activity in S pseudovirus inhibition assays and phagocytic activity in an antibody-dependent phagocytosis assay.</div></div><div><h3>Results</h3><div>Robust S-reactive IgM, IgG and IgA ELISA titers were found at day 7 after enrollment, with IgG and IgA levels persisting through 6 months. The majority of S-reactive IgA in milk was secretory in nature. Strong IgG (mean IC₅₀ value 29.19μg/ml) and IgA (mean IC₅₀ value 10.17μg/ml) nAb activity was found in all convalescent samples at 14 days with a decline by 3 months after the onset of symptoms but was not seen in pre-pandemic controls. Both IgG and IgA antibodies mediated phagocytic activity in samples from all subjects by day 14 after the onset of symptoms.</div></div><div><h3>Conclusions</h3><div>Our findings indicate that human milk from SARS-CoV-2 infected mothers have the capacity to transfer SARS-CoV-2-specific antibodies capable of mediating multiple functional activities to newborns via breastfeeding.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 215-226"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamin D levels in older adults with and without dyslipidemia: A comparison using baseline data from the Birjand Longitudinal Aging Study (BLAS)","authors":"Fatemeh Alizadeh ,&nbsp;Fatemeh Salmani ,&nbsp;Farshad Sharifi ,&nbsp;Mitra Moodi ,&nbsp;Masomeh Khorashadizadeh ,&nbsp;Zoya Tahergorabi","doi":"10.1016/j.nutos.2024.10.004","DOIUrl":"10.1016/j.nutos.2024.10.004","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Nowadays, research on extraskeletal effects of Vitamin D on human health is growing This study aimed to Serum vitamin D levels measurement in older adults with and without dyslipidemia: a comparison using baseline data from the Birjand Longitudinal Aging Study (BLAS).</div></div><div><h3>Methods</h3><div>This cross-sectional study included 420 elderly people over 60 years old divided into in two equal groups with and without dyslipidemia. Data were drawn from the first phase of Birjand Longitudinal Aging Study (BLAS). A questionnaire containing demographic information and Mini nutritional assessment (MNA) was completed through interviews. Body mass index (BMI) was calculated, and after 12 hours of fasting, 5 mL of venous blood was taken to measure the serum levels of 25(OH) D and lipid profile.</div></div><div><h3>Results</h3><div>Among the elderly, 37.3%, 33.3% and 29.3% had sufficient, insufficient and deficient Vitamin D levels, respectively. A significant difference in triglyceride levels was observed between the two groups of elderly individuals with insufficient and deficient Vitamin D levels (<em>P</em>=0.011). Multiple logistic regression showed that an increase in the atherogenic index of plasma (AIP) (<em>P</em> = 0.005, OR = 18.46) and BMI (<em>P</em> = 0.001, OR = 18.46) significantly increased the odds of dyslipidemia.</div></div><div><h3>Conclusions</h3><div>Vitamin D deficiency or insufficient was common among the elderly and was associated with elevated serum triglyceride levels.</div></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"58 ","pages":"Pages 155-162"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}