Association of gene methylation status RLEP, LEP, FTO, BDNF and COMT with risk factors for eating disorders in Mexican university students

Q3 Nursing

Clinical Nutrition Open Science Pub Date : 2025-06-25 DOI:10.1016/j.nutos.2025.06.004

R.G. Garfias-Guzmán , M. de Lorena Ramos-García , C. Castro-Hernández , L. Casas-Ávila , O.C. Martínez-Ramírez

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Abstract

Eating Disorders are complex conditions characterized by negatively impact a person's physical and mental health. Risky eating behavior are closely related to risk factors such as BMI, sex, depression, and anxiety.

Aim

The objective of this study is to determine the association of gene methylation status RLEP, LEP, FTO, BDNF, and COMT with the risk factors for eating disorders in Mexican university students.

Methods

An analytical cross-sectional study was carried out. Data on risky eating behavior, anxiety, and depression were collected using self-applicable questionnaires EAT, BAI, and BECK, respectively. The methylation of the genes was determined by MSP-PCR.

Results

We included 83 individuals, 61.4% women, and 38.6% men. Our results showed an association between the risk of eating disorders and anxiety and/or depression. When we determine the interaction between genes and risk factors, we find that the greater the number of risk variables, the greater the association of presenting risky eating behavior in Mexican university students.

Conclusion

We found an association between risk factors, especially depression and anxiety, with risky eating behavior in Mexican university students.

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基因甲基化状态RLEP、LEP、FTO、BDNF和COMT与墨西哥大学生饮食失调危险因素的关系

饮食失调是一种复杂的疾病，其特征是对人的身心健康产生负面影响。危险饮食行为与身体质量指数、性别、抑郁和焦虑等风险因素密切相关。目的本研究的目的是确定基因甲基化状态RLEP、LEP、FTO、BDNF和COMT与墨西哥大学生饮食失调危险因素的关系。方法采用分析性横断面研究。分别使用自适用的EAT、BAI和BECK问卷收集风险饮食行为、焦虑和抑郁的数据。MSP-PCR检测基因的甲基化程度。结果纳入83例，女性61.4%，男性38.6%。我们的研究结果表明，饮食失调的风险与焦虑和/或抑郁之间存在关联。当我们确定基因和风险因素之间的相互作用时，我们发现风险变量的数量越多，墨西哥大学生出现危险饮食行为的关联就越大。结论：我们发现墨西哥大学生的危险因素，尤其是抑郁和焦虑，与危险饮食行为之间存在关联。

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