Kartika Jurnal Ilmiah Farmasi最新文献

{"title":"The relationship between knowledge and community behavior in improving the immune system during the COVID-19 pandemic era in Barong Tongkok Village","authors":"Stevania Windi, Lucia Vita Inandha Dewi, Inaratul Rizkhy Hanifah","doi":"10.20885/jif.vol19.iss1.art6","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art6","url":null,"abstract":"Background: Within 2 years of the COVID-19 pandemic, stopping the spread of COVID-19 in the community can be done with adequate knowledge about immune system improvement behaviors and the use of health supplements to improve the body's immune system. Objective: This study aims to determine the relationship between the level of knowledge and community behavior in improving the immune system in Barong Tongkok Village in the era of the COVID-19 pandemic. Method: This study is a quantitative type with a cross-sectional method conducted in Barong Tongkok Village with a total sample of 356 respondents from 4,787 total populations. Analysis of results is carried out with univariate tests to concentrate and display data, while bivariate tests are statistical analyses of chi-square tests to see the relationship between two variables. Results: A univariate analysis revealed that the level of knowledge in the high category was 55.6% and the behavior of improving the immune system in the good category was 50.8%. The results of the bivariate test analysis with the chi-square test revealed a significant relationship between the level of knowledge and the behavior of improving the immune system (p = 0.000). Conclusion: There is a relationship between the level of knowledge and the behavior of improving the immune system in Barong Tongkok Village. Keywords: Level of knowledge, behavior, immune system, COVID-19 pandemic","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89644876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interferons and its use in children with COVID-19: A narrative review","authors":"Chairunnisa Chairunnisa, S. Suharjono","doi":"10.20885/jif.vol18.iss2.art18","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art18","url":null,"abstract":"Background: All ages, including children, are susceptible to the disease COVID-19. The severity of COVID-19 in children is mild than in adults. One of the recommended antiviral drugs for COVID-19 in children is interferon.\u0000Objective: To describe the efficacy and safety of using interferon in children with COVID-19\u0000Method: The article is a narrative study. The main databases in the article search process in this literature review are PubMed and Google Scholar.\u0000Results: The articles could potentially be involved in this study were 28 articles. A total of 13 articles included the criteria, 9 articles discussed the use of interferon against respiratory syndrome, 4 articles on interferon in children, and one reference from a literature search.\u0000Conclusion: Interferon therapy in COVID-19 in children has a high cure rate but needs to be evaluated in a larger sample of pediatric patients.","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80020693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo nephroprotective effect of herbal plants towards gentamicin-induced nephrotoxicity: A literature review","authors":"Erlyn Dwi Cahyani, R. A. Prasetya, Izzatul Ma'rifah, Deby Nanda Tri Widia, Tiara Sri Dewi, Sulfa Putri","doi":"10.20885/jif.vol18.iss2.art17","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art17","url":null,"abstract":"Latar belakang: Gentamisin berpotensi menyebabkan nefrotoksisitas karena akumulasi dalam nefron dan memicu produksi radikal bebas. Karena itu, tubuh merespon dengan memproduksi antioksidan endogen. Namun, banyaknya radikal bebas yang terbentuk membutuhkan antioksidan eksogen dari tanaman herbal untuk mengimbanginya. Hanya saja diperlukan uji preklinis dan klinis untuk membuktikan khasiat dari tanaman obat yang dapat melindungi ginjal dari nefrotoksisitas gentamisin. \u0000Tujuan: Artikel ini memberikan gambaran secara ilmiah tentang efek nefroprotektif tanaman herbal pada diinduksi gentamisin secara in vivo. \u0000Metode: Pencarian literatur melalui basis data ScienceDirect pada bulan Juli 2022 menggunakan kata kunci “kerusakan ginjal”, “tanaman herbal”, dan “gentamisin” diperoleh total 12 untuk direviu. \u0000Hasil: Didapatkan 12 tanaman herbal yang terbukti dapat mengembalikan penurunan fungsi ginjal karena kerusakan yang diinduksi gentamisin. Hal ini terlihat dari peningkatan signifikan kadar BUN dan/atau kreatinin pada hewan coba yang mendapat terapi tanaman herbal dibandingkan kelompok perlakuan gentamisin. Efek nefroprotektif pada tanaman disebabkan adanya kandungan beberapa senyawa seperti flavonoid, polifenol, dan tanin. Walaupun masing-masing tanaman memiliki kandungan senyawa yang berbeda-beda, namun semuanya memiliki aktivitas antioksidan untuk melindungi ginjal dengan mekanisme menghambat atau mencegah terjadinya oksidasi dalam sel pada ginjal karena induksi gentamisin. \u0000Kesimpulan: Kandungan antioksidan senyawa pada tanaman herbal berpotensi untuk mencegah atau mengatasi nefrotoksisitas akibat penggunaan gentamisin.","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87391199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analisis biaya pasien Severe Cutaneous Adverse Reactions (SCARs)","authors":"Qarriy Aina Urfiyya, Musa Fitri Fatkhiya, D. Perwitasari, S. Febriana, W. Supadmi","doi":"10.20885/jif.vol18.iss2.art12","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art12","url":null,"abstract":"Latar belakang: Severe Cutaneous Adverse Reactions (SCARs) termasuk Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN) dan Drug Reaction with Eosinophilia and Systemic Symptom (DRESS), merupakan reaksi idiosinkratik yang paling sering disebabkan oleh obat yang berdampak pada peningkatan beban keuangan pasien.\u0000Tujuan: Penelitian ini bertujuan untuk mengetahui komponen biaya terbesar dan biaya perawatan pada pasien yang mengalami Severe Cutaneous Adverse Reactions (SCARs).\u0000Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Pengumpulan data biaya medik langsung, biaya non medik langsung dan biaya tidak langsung pada pasien rawat inap dengan SJS, TEN dan DRESS di RSUP Dr. Sardjito Yogyakarta tahun 2014-2018, secara retrospektif. Kami menghitung komponen biaya tertinggi dan biaya perawatan pasien dengan SCARs berdasarkan perspektif masyarakat.\u0000Hasil: Komponen biaya tertinggi pada pasien SJS dan TEN adalah biaya jasa profesional kesehatan (24,1% and 25,2%), sedangkan komponen biaya tertinggi pada pasien DRESS adalah biaya obat (20,2%). Total biaya perawatan 47 pasien SCARs (22 pasien SJS, 6 pasien TEN, dan 19 pasien DRESS) adalah Rp 666.615.321, dengan biaya rata-rata tertinggi pada pasien TEN, diikuti SJS dan DRESS (Rp 16.510.595, Rp 14.205.545, and Rp 13.445.555)\u0000Kesimpulan: Komponen biaya terbesar adalah biaya jasa professional kesehatan pada pasien SJS dan TEN, serta biaya obat bagi pasien DRESS. Penatalaksanaan SCARs membutuhkan biaya yang cukup besar, dan masih menjadi beban keuangan bagi pasien.","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89348081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skrining senyawa Eurycoma longifolia terhadap siklus sel dengan metode docking melalui interaksi cylcin","authors":"Samsul Hadi, Khoerul Anwar, Noer Komari, Desiya Ramayanti Azhara, D. Rosanti","doi":"10.20885/jif.vol18.iss2.art15","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art15","url":null,"abstract":"Latar belakang: Pasak bumi telah dikenal oleh masyarakat secara turun-temurun untuk meningkatkan gairah seksual pada pria (afrodisiaka). Disamping itu dapat meningkatkan performa atlet olahraga dan sebagai antistress, menurunkan tegangan, kemarahan, dan kebingungan. \u0000Tujuan: Penggunaan yang relatif banyak ini mendorong peneliti berkeinginan melakukan skrining senyawa aktif terhadap antitumor secara in silico dengan melalui 2 tahap yaitu melalaui PASS online dan docking.  \u0000Metode: Metode docking dipakai untuk melihat interaksi stabilitas senyawa dengan cylin. Dalam pengujian ini, Pyrx digunakan sebagai alat docking dengan berbagai target yang berhubungan dengan siklus sel, yaitu cyclin D3 (PDB ID: 3G33), cyclin A (PDB ID: IJSU), cyclin C (PDB ID: 1ZP2), cyclin D (ID PDB: 2W9F), cyclin H (ID PDB: 1KXU), dan cyclin T (ID PDB: 3BLR). \u0000Hasil: Hasil docking pada masing-masing cyclin menunjukkan interaksi terbaik dengan senyawa berikut ini: cyclin A dan 9-Methoxycanthin-6-one 3-N-oxide (-8,6 Kkal/mol), cyclin H dan Niloticin (-8,0 Kkal/mol), cyclin D3 dan 9-Methoxycanthin-6-one 3-N-oxide (-7,2 Kkal/mol), cyclin D dan Eurycolactone F (-8,4 Kkal/mol), cyclin C dan Niloticin (-7,5 Kkal/mol), serta cyclin T dan Niloticin (-8,2 Kkal/mol). \u0000Kesimpulan: Berdasarkan skor docking yang diperoleh, kestabilan interaksi diprediksi akan terjadi pada cyclin A dengan 9-Methoxycanthin-6-one 3-N-oxide (delta G: -8.6 Kkal/mol).","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77687668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of single and combination chemotherapy agents in patients with metastatic breast cancer","authors":"Martanty Aditya, Godeliva Adriani Hendra, Suhul Raos Kumawula Ing Gustyas","doi":"10.20885/jif.vol18.iss2.art14","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art14","url":null,"abstract":"Background: There are several ways to treat breast cancer, one of which is administering chemotherapy agents. Chemotherapy agents have activity in inhibiting the cell cycle. That will affect the effectiveness of therapy and the side effects of chemotherapy agents.\u0000Objective: This study aimed to evaluate single and combination chemotherapy agent therapeutic efficacy and side effects\u0000Method: The design of this study used an observational cohort study with retrospective data collection from January to December 2019. Patients obtained from medical records were diagnosed with metastatic stage of breast cancer at Panti Nirmala Hospital, Malang. The effectiveness of the chemotherapy agent was seen from the carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3), which were carried out in the first and third cycles, then analyzed using the Wilcoxon and U-Mann Whitney tests. Side effects of chemotherapy agents were analyzed descriptively.\u0000Results: Analysis of the Wilcoxon test showed differences between the two groups of chemotherapeutic agents in CEA and CA15-3 (p<0.05). U-Mann Whitney test analysis showed no difference after administration of the two groups of chemotherapy agents at CEA (p>0.05). However, there was a difference in CA15-3 (p<0.05). Both chemotherapy agents showed most common side effects such as pain, nausea,  vomiting, and alopecia.\u0000Conclusion: Patients who received a combination of chemotherapy agents had lower CA15-3 levels than single chemotherapy agents.","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77066401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potensi Enzim Superoksida Dismutase dari Biji Jagung (Zea Mays L.) untuk Perbaikan Sel Fibroblas 3t3 Yang Dipaparkan Sinar Ultraviolet A","authors":"Mustika Endah Pratiwi, Jason Merari Peranginangin, Isna Jati Asiya, Ana Indrayati","doi":"10.20885/jif.vol18.iss2.art16","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art16","url":null,"abstract":"Latar belakang: Radiasi sinar UV-A memicu gangguan pada kulit yang disebut fotoaging. Fotoaging ditangani dengan zat antioksidan. SOD merupakan antioksidan enzimatis lini pertama dalam penanganan radikal bebasTujuan: Tujuan dari penelitian ini adalah untuk mengetahui aktifitas antifotoaging ekstrak SOD biji jagung pada sel fibroblas 3T3 yang dipaparkan sinar UV-A.Metode: Ekstraksi SOD biji jagung dilakukan menggunakan metode sentrifugasi, presipitasi dan dialisis. Aktivitas SOD dari ekstrak SOD biji jagung dilakukan dengan menggunakan metode WST-1. Aktivitas antifotoaging ekstrak SOD biji jagung dilakukan pada sel fibroblas 3T3 yang dipaparkan sinar UV-A dengan parameter viabilitas sel. Pengujian aktivitas antifotoaging menggunakan kontrol sel, kontrol negatif, sampel dan kontrol positif. Hasil pengukuran aktivitas antifotoaging ekstrak SOD biji jagung dianalisis menggunakan One Way ANOVA dengan uji Tukey.Hasil: Persen inhibisi aktivitas SOD tertinggi yaitu pada ekstrak SOD biji jagung presipitasi amonium sulfat konsentrasi 60-90%. Aktivitas antifotoaging ekstrak SOD biji jagung menunjukkan perbedaan bermakna pada nilai persen viabilitas sel pada sel fibroblas antara kelompok ekstrak dengan kelompok kontrol negatif dengan hasil persen viabilitas sel tertinggi yaitu pada ekstrak SOD biji jagung konsentrasi 100 mg/ml. Nilai EC90 untuk parameter viabilitas sel yaitu sebesar 12,57 mg/ml dan 69,47 mg/ml.Kesimpulan: Ekstrak SOD dari biji jagung terbukti memiliki aktivitas sebagai antioksidan yang dapat digunakan sebagai anti fotoaging melalui mekanisme perbaikan sel fibroblast.Kata kunci : Biji jagung, antifotoaging, kolagen, SOD, sel fibroblas 3T3","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80051574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REVIEW: RANDOMIZED CLINICAL TRIAL STUDY OF INFLUENZA VACCINE IN CHILDREN AGE 6-35 MONTHS","authors":"C. Suhandi, Cheryl Alodya, Abednego Kristande, R. Sinuraya","doi":"10.20885/jif.vol18.iss2.art13","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art13","url":null,"abstract":"AbstractBackground: Influenza is a contagious viral infection disease that causes acute disorders of the respiratory tract. The prevalence of infection due to influenza virus is higher in children than adults. Thus, it is very important to vaccinate children using the most effective type of vaccine.Tujuan: The purpose of this review was to investigate type of influenza vaccine with the highest effectiveness in children aged 6-35 months based on Randomized Control Trial study.Method: The review is carried out by collecting articles from Elsevier and Medline database using “Influenza Vaccine”, “Randomized Control Trial”, and “Children” as the keywords.Results: Based on the initial searching, it was found 6.261 articles and 9 articles that fulfill the review criteria. The results showed that the best vaccine efficacy has gotten by trivalent vaccines against the strains of viruses A (H1N1), A (H3N2), and B (Yamagata) with vaccine efficacy values of 94.1%; 100%; and 97.1%, respectively. While the use of quadrivalent vaccines against strain B (Victoria) virus with a vaccine efficacy value of 87.2%.Conclusion: Trivalent vaccine more effective for strain A and B (Yamagata) virus, moreover quadrivalent vaccine more effective for strain B (Victoria)Keyword: Influenza, Vaccine, Children, Trivalent, Quadrivalent AbstrakLatar Belakang: Influenza merupakan suatu penyakit infeksi virus menular yang mengakibatkan gangguan akut pada saluran pernapasan. Insidensi infeksi akibat virus influenza lebih tinggi terjadi pada anak-anak dibanding dewasa. Dengan demikian, sangat penting untuk memberikan vaksinasi pada anak-anak menggunakan jenis vaksin yang paling efektif.Tujuan: Tujuan dari review ini adalah untuk menentukan jenis vaksin influenza dengan efektivitas tertinggi terhadap anak usia 6-35 bulan berdasarkan hasil studi Randomized Control Trial.Metode: Review dilakukan dengan penelusuran pustaka pada database ELSEVIER dan MEDLINE dengan kata kunciInfluenza Vaccine Randomized Control Trial Children.Hasil: Berdasarkan hasil penelusuran, diperoleh 6.261 artikel dan 9 artikel yang memenuhi kriteria review. Hasil telaah menunjukkan efektivitas vaksin terbaik pada vaksin trivalent terhadap virus strain A (H1N1), A (H3N2), dan B (Yamagata) dengan nilai efikasi vaksin secara berurutan sebesar 94,1%; 100%; dan 97,1%. Sedangkan penggunaan vaksin quadrivalent terhadap virus strain B (Victoria) dengan nilai efikasi vaksin 87,2%.Kesimpulan: Vaksin trivalent lebih efektif pada virus strain A dan B (Yamagata), sedangkan vaksin quadrivalent lebih efektif pada strain B (Victoria)Kata kunci: Influenza, Vaksin, Anak-anak, Trivalent, Quadrivalent","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90285256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Karakterisasi dan Penetapan Kadar Flavonoid Total Ekstrak dan Fraksi Bunga Pepaya Jantan (Carica papaya L.) dengan Spektrofotometri UV-Vis","authors":"Dilla Nur Pratiwi, Nastiti Utami, Diah Pratimasari","doi":"10.20885/jif.vol18.iss2.art20","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art20","url":null,"abstract":"AbstractBackground: The potential of male papaya flowers (Carica papaya L.) as functional herbal ingredients, such as antioxidants, is influenced by the activity of secondary metabolites, one of them is flavonoid.Objective: This study to determine the content of flavonoid and characterization flavonoids in ethanol extract and fractions of male papaya flower (Carica papaya L.).Method: Male papaya flower was maceration using ethanol 70% then fractionated using multilevel fractionation. Identification flavonoid was tested by using the Taubeck, Wilstater, and TLC. Extract and fractions were determined the content of flavonoid using colorimetric method and identification of flavonoids based on the wavelength of cinnamoyl and benzoyl in the spectrum UV-Vis.Results: The results of the determination of flavonoid content showed that ethanol extract was the highest 0.6805 ± 0.0045 %QE and n-hexane fractions was the lowest 0.4178 ± 0.0058 %QE. Identification of flavonoids using UV-Vis spectroscopy method showed the absorption of substituted 3-OH flavonol and free 3-OH flavonol.Conclusion: The highest flavonoid content was found in the ethanol extract of male papaya flower. The types of flavonoids in the extract and fractions of male papaya flower indicated the type of flavonol based on the wavelength of cinnamoyl and benzoyl.Keywords: carica, flavonoid, cinnamoyl, benzoyl, UV-Vis Intisari Latar belakang: Potensi bunga pepaya jantan (Carica papaya L.) sebagai bahan fungsional herbal, seperti antioksidan dipengaruhi oleh aktivitas dari metabolit sekunder, salah satunya flavonoid.Tujuan: Penelitian ini bertujuan untuk mengetahui kadar flavonoid total serta karakterisasi flavonoid dalam ekstrak etanol dan fraksi bunga pepaya jantan (Carica papaya L.).Metode: Bunga pepaya jantan dilakukan maserasi dengan etanol 70%, dilanjutkan fraksinasi bertingkat. Identifikasi flavonoid dilakukan menggunakan metode Taubeck, Wilstater dan KLT. Kadar flavonoid ekstrak dan fraksi ditetapkan menggunakan metode kolorimetri serta identifikasi flavonoid berdasarkan pita cinnamoyl dan benzoyl pada spektrum UV-Vis.Hasil: Hasil penetapan kadar flavonoid menunjukkan bahwa ekstrak etanol memiliki kadar tertinggi sebesar 0,6805 ± 0,0045 %QE, serta kadar terendah dalam fraksi n-heksan sebesar 0,4178 ± 0,0058 %QE. Identifikasi flavonoid metode spektrofotometri UV-Vis menunjukkan penyerapan flavonol 3-OH substitusi dan flavonol 3-OH bebas.Kesimpulan: Kadar flavonoid tertinggi ditemukan dalam ekstrak etanol bunga pepaya. Jenis flavonoid dalam ekstrak dan fraksi bunga pepaya jantan mengindikasikan jenis flavonol berdasarkan panjang gelombang dari cinnamoyl dan benzoyl.Kata kunci : carica, flavonoid, cinnamoyl, benzoyl, UV-Vis","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78399956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phyllanthus niruri (Meniran) Sebagai Imunomodulator: Mekanisme aksi dan senyawa bioaktif","authors":"Uzulul Hikmah, Asih Triastuti","doi":"10.20885/jif.vol18.iss2.art19","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art19","url":null,"abstract":"Latar belakang: Phyllanthus niruri merupakan tanaman obat yang memiliki beberapa aktivitas farmakologi seperti antimikroba, antioksidan, antikanker, antiinflamasi, antiplasmodium, antivirus, diuretik, hepatoprotektif, dan sebagai imunomodulator. \u0000Tujuan: Melakukan tinjauan analisis mengenai efektivitas P. niruri) sebagai imunomodulator pada uji preklinis maupun uji klinis. \u0000Hasil: Kandungan kimia P. niruri seperti flavonoid, lignan, terpenoid, dan alkaloid berperan penting pada aktivitas farmakologi P. niruri sebagai imunomodulator.  Uji in silico menunjukkan potensi P. niruri sebagai imunomodulator pada infeksi Covid-19 dengan berikatan pada protein spike dan protease yang bertanggungjawab pada replikasi dan pematangan virus. Uji in vitro dan in vivo menunjukkan bahwa P. niruri mampu meningkatkan aktivitas fagositosis dari makrofag, meningkatkan antibodi serum total, dan mengurangi inflamasi. Pengujian klinis membuktikan bahwa P. niruri memiliki aktivitas imunomodulator baik pada subjek uji sehat maupun pada pasien. \u0000Kesimpulan: Phyllanthus niruri memiliki aktivitas sebagai imunomodulator baik pada pengujian preklinis maupun klinis. \u0000Kata kunci : Phyllanthus niruri, Imunomodulator, Imunostimulan, Metabolit sekunder","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84992597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}