Kartika Jurnal Ilmiah Farmasi最新文献_第2页

Analisis determinan terhadap Length of Stay (LoS) di ruang isolasi Covid-19 RSUD Jend. A. Yani Kota Metro 在Covid-19 RSUD Jend将军的隔离室中确定停留的长度(LoS)的分析。亚尼镇地铁

Kartika Jurnal Ilmiah Farmasi Pub Date : 2023-07-31 DOI: 10.20885/jif.vol19.iss1.art7

Devina Harti Syaputri, D. Laksmitawati, P. Sarnianto, Andreas Infianto

{"title":"Analisis determinan terhadap Length of Stay (LoS) di ruang isolasi Covid-19 RSUD Jend. A. Yani Kota Metro","authors":"Devina Harti Syaputri, D. Laksmitawati, P. Sarnianto, Andreas Infianto","doi":"10.20885/jif.vol19.iss1.art7","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art7","url":null,"abstract":"Intisari Latar belakang: Angka kejadian Coronavirus Disease 2019 (COVID-19) yang mengalami peningkatan di Indonesia mempengaruhi kebutuhan layanan rawat inap rumah sakit. Salah satu parameter mutu layanan dan penggunaan sumber daya rumah sakit adalah length of stay (LOS).Tujuan: Untuk mencari determinan COVID-19 yang berpengaruh terhadap LOS di rumah sakit.Metode: Pengambilan data secara retrospektif observasional menggunakan desain studi cross sectional. Metode pengambilan sampel menggunakan total sampling selama periode rawat Januari-Agustus 2021 di Ruang Isolasi RSUD Jend. A. Yani Kota Metro. Data yang digunakan adalah data rekam medis. Analisis bivariat dengan menggunakan Chi Square, sedangkan analisis multivariat menggunakan Regresi Logistik Ganda.Hasil: Sampel berjumlah 443 pasien yang di rawat selama periode Januari-Agustus 2021 di ruang isolasi COVID-19 RSUD Jend. A. Yani Kota Metro. Median LOS adalah 6 hari. Analisis regresi logistik ganda menunjukkan bahwa determinan LOS meliputi; tingkat keparahan, diabetes mellitus, penyakit jantung, D-Dimer.Kesimpulan: Tingkat keparahan, komorbid diabetes mellitus, komorbid penyakit jantung, nilai D-Dimer merupakan determinan terhadap LOS pasien COVID-19 terkonfirmasi di ruang isolasi COVID-19 RSUD Jenderal Ahmad Yani Provinsi Lampung.Kata kunci: Determinan, Coronavirus Disease, LOS, rumah sakit","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81222973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation and development of UV-Vis spectrophotometer analysis methods for alpha-tocopherol acetate 紫外-可见分光光度法测定α -生育酚醋酸酯方法的验证与发展

Kartika Jurnal Ilmiah Farmasi Pub Date : 2023-03-03 DOI: 10.20885/jif.vol19.iss1.art8

Arif Al Iman, Winni Auli, S. Sukrasno

{"title":"Validation and development of UV-Vis spectrophotometer analysis methods for alpha-tocopherol acetate","authors":"Arif Al Iman, Winni Auli, S. Sukrasno","doi":"10.20885/jif.vol19.iss1.art8","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art8","url":null,"abstract":"Background: The COVID-19 pandemic had caused the consumption of vitamins in the community to increase with the aim of maintaining immunity in the body. Objective: This study aims to develop an analysis method with a UV-Vis spectrophotometer, which is considered an alternative analysis method that is easier, more practical, and cheaper. Method: Methods for analyzing alpha-tocopherol acetate are validated through specificity tests, linearity measurements, precision tests, accuracy tests, determination of detection limits, determination of quantitation limits, and determination of range using ethanol p.a solvent and UV-Vis Spectrophotometer instruments. Then, examine the alpha tocopherol acetate content of vitamin E dietary supplements. Results: The specificity test showed that matrix had no significant effect on the analysis, the linearity test met the requirements with a concentration range of 20–60 ug/mL (r = 0.9991), the accuracy test was 99.897-100.315%, intraday and interday precision tests were obtained with %RSD less than 2%, the LOD value was 1.859 ug/mL and the LOQ value was 5.635 ug/mL. The determination of levels of vitamin E in dietary supplements showed levels for brand A of 100.508% and brand B of 100.089%. Conclusion: The analytical method developed had met the validation requirements, and the levels of vitamin E food supplements had met the USP requirements. Keywords: method validation, UV-Vis spectrophotometer, alpha tocopherol acetate","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"76 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78139741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation of antifungal bioactive compounds from an ethanolic extract of beluntas leaves (Pluchea indica) against Microsporum canis 白桦叶乙醇提取物对犬小孢子虫抗真菌活性化合物的分离

Kartika Jurnal Ilmiah Farmasi Pub Date : 2023-03-03 DOI: 10.20885/jif.vol19.iss1.art5

Devi Safitri, M. Muhaimin, Nelson Nelson, I. L. Tarigan, L. Lizawati, M. Latief

{"title":"Isolation of antifungal bioactive compounds from an ethanolic extract of beluntas leaves (Pluchea indica) against Microsporum canis","authors":"Devi Safitri, M. Muhaimin, Nelson Nelson, I. L. Tarigan, L. Lizawati, M. Latief","doi":"10.20885/jif.vol19.iss1.art5","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art5","url":null,"abstract":"Background: Fungus prevalence in Indonesia is still relatively high. This happens because Indonesia has high temperatures and humidity. Beluntas (Pluchea indica) is a shrub native to Indonesia and widely distributed in most parts of the country. Pluchea indica is usually used by the community as a medicine for skin diseases. The bioactive content of P. indica leaves has potential as an antifungal agent. One of the fungi that is pathogenic to humans is Microsporum canis. Method: N-hexane, ethyl acetate, and ethanol served as the solvents for the graded maceration method of extraction over two 24-hour periods. Furthermore, using Vacuum Liquid Chromatography (VLC) and characterization with UV-Vis and FT-IR. Antifungal activity was performed by disc diffusion method. Results: Pluchea indica leaves have antifungal activity in the ethanol extract of 20.08 mm (very strong), the F5 fraction of 22.24 mm (very strong), and the F5 isolate of 6.3 mm (weak) at a concentration of 4%. Based on the UV-Vis and FT-IR data, the isolate had a wavelength of 267 nm with a functional group of -OH, C=C aromatic, C-H, and C-O. Conclusion: Isolate from the ethanol extract of Pluchea indica leaves has potential as an antifungal originating from the flavonoid group. Keywords: Pluchea indica, antifungal, Microsporum canis, isolation compound","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82214719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Study of Monascus sp. Pigment Derivatives as Anticardiovascular Candidate 红曲霉色素衍生物抗心血管候选物的硅研究

Kartika Jurnal Ilmiah Farmasi Pub Date : 2023-03-03 DOI: 10.20885/jif.vol19.iss1.art1

D. Zain, Anna Yuliana

{"title":"In Silico Study of Monascus sp. Pigment Derivatives as Anticardiovascular Candidate","authors":"D. Zain, Anna Yuliana","doi":"10.20885/jif.vol19.iss1.art1","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art1","url":null,"abstract":"Background: Cardiovascular disease is the leading cause of death in the world. The therapeutic activity of Monascus sp. pigment can act as an anticardiovascular agent. Research on Monascus sp. pigment is rapidly developing, including the discovery of new pigments, the methods used, and their identification. Currently, there are 57 dyestuff compounds that have been successfully isolated from Monascus molds. So, researchers conducted an in-silico study of Monascus sp. Objective: To determine whether it can have better interactions and activities as an anticardiovascular medicine candidate. Method: PAK1 is used as a receptor for anticardiovascular drugs. 57 test compounds were carried out for ligand preparation and application of Lipinski's rule of five by using MarvinSketch software, ADME prediction and toxicity testing using PreADMET, the docking process using Autodock tools, and visualization using Discovery Studio. Results: The results of the docking analysis are seen from the values of binding affinity consecutively. compound R3 (-8.74 kcal/mol), red shandong (-8.16 kcal/mol), and monaphilol (-8.14 kcal/mol) are lower than the comparison compound bisoprolol (-6.44 kcal/mol), which shows that the three compounds have better interactions than the comparison compounds. Conclusion: Derivative compounds from Monascus sp. Pigment are predicted to have better interactions and can be used as anticardiovascular medicine candidates. Keywords: Monascus sp., pigment, anticardiovascular, in silico, PAK1, ADME, and toxicity","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88599449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between knowledge and community behavior in improving the immune system during the COVID-19 pandemic era in Barong Tongkok Village 新冠肺炎大流行时期巴龙通角村知识与社区行为对免疫系统改善的关系

Kartika Jurnal Ilmiah Farmasi Pub Date : 2023-03-03 DOI: 10.20885/jif.vol19.iss1.art6

Stevania Windi, Lucia Vita Inandha Dewi, Inaratul Rizkhy Hanifah

{"title":"The relationship between knowledge and community behavior in improving the immune system during the COVID-19 pandemic era in Barong Tongkok Village","authors":"Stevania Windi, Lucia Vita Inandha Dewi, Inaratul Rizkhy Hanifah","doi":"10.20885/jif.vol19.iss1.art6","DOIUrl":"https://doi.org/10.20885/jif.vol19.iss1.art6","url":null,"abstract":"Background: Within 2 years of the COVID-19 pandemic, stopping the spread of COVID-19 in the community can be done with adequate knowledge about immune system improvement behaviors and the use of health supplements to improve the body's immune system. Objective: This study aims to determine the relationship between the level of knowledge and community behavior in improving the immune system in Barong Tongkok Village in the era of the COVID-19 pandemic. Method: This study is a quantitative type with a cross-sectional method conducted in Barong Tongkok Village with a total sample of 356 respondents from 4,787 total populations. Analysis of results is carried out with univariate tests to concentrate and display data, while bivariate tests are statistical analyses of chi-square tests to see the relationship between two variables. Results: A univariate analysis revealed that the level of knowledge in the high category was 55.6% and the behavior of improving the immune system in the good category was 50.8%. The results of the bivariate test analysis with the chi-square test revealed a significant relationship between the level of knowledge and the behavior of improving the immune system (p = 0.000). Conclusion: There is a relationship between the level of knowledge and the behavior of improving the immune system in Barong Tongkok Village. Keywords: Level of knowledge, behavior, immune system, COVID-19 pandemic","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89644876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo nephroprotective effect of herbal plants towards gentamicin-induced nephrotoxicity: A literature review 植物对庆大霉素肾毒性的体内肾保护作用:文献综述

Kartika Jurnal Ilmiah Farmasi Pub Date : 2022-12-30 DOI: 10.20885/jif.vol18.iss2.art17

Erlyn Dwi Cahyani, R. A. Prasetya, Izzatul Ma'rifah, Deby Nanda Tri Widia, Tiara Sri Dewi, Sulfa Putri

{"title":"In vivo nephroprotective effect of herbal plants towards gentamicin-induced nephrotoxicity: A literature review","authors":"Erlyn Dwi Cahyani, R. A. Prasetya, Izzatul Ma'rifah, Deby Nanda Tri Widia, Tiara Sri Dewi, Sulfa Putri","doi":"10.20885/jif.vol18.iss2.art17","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art17","url":null,"abstract":"Latar belakang: Gentamisin berpotensi menyebabkan nefrotoksisitas karena akumulasi dalam nefron dan memicu produksi radikal bebas. Karena itu, tubuh merespon dengan memproduksi antioksidan endogen. Namun, banyaknya radikal bebas yang terbentuk membutuhkan antioksidan eksogen dari tanaman herbal untuk mengimbanginya. Hanya saja diperlukan uji preklinis dan klinis untuk membuktikan khasiat dari tanaman obat yang dapat melindungi ginjal dari nefrotoksisitas gentamisin. \u0000Tujuan: Artikel ini memberikan gambaran secara ilmiah tentang efek nefroprotektif tanaman herbal pada diinduksi gentamisin secara in vivo. \u0000Metode: Pencarian literatur melalui basis data ScienceDirect pada bulan Juli 2022 menggunakan kata kunci “kerusakan ginjal”, “tanaman herbal”, dan “gentamisin” diperoleh total 12 untuk direviu. \u0000Hasil: Didapatkan 12 tanaman herbal yang terbukti dapat mengembalikan penurunan fungsi ginjal karena kerusakan yang diinduksi gentamisin. Hal ini terlihat dari peningkatan signifikan kadar BUN dan/atau kreatinin pada hewan coba yang mendapat terapi tanaman herbal dibandingkan kelompok perlakuan gentamisin. Efek nefroprotektif pada tanaman disebabkan adanya kandungan beberapa senyawa seperti flavonoid, polifenol, dan tanin. Walaupun masing-masing tanaman memiliki kandungan senyawa yang berbeda-beda, namun semuanya memiliki aktivitas antioksidan untuk melindungi ginjal dengan mekanisme menghambat atau mencegah terjadinya oksidasi dalam sel pada ginjal karena induksi gentamisin. \u0000Kesimpulan: Kandungan antioksidan senyawa pada tanaman herbal berpotensi untuk mencegah atau mengatasi nefrotoksisitas akibat penggunaan gentamisin.","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87391199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analisis biaya pasien Severe Cutaneous Adverse Reactions (SCARs) 严重皮肤不良反应(scar)分析

Kartika Jurnal Ilmiah Farmasi Pub Date : 2022-12-30 DOI: 10.20885/jif.vol18.iss2.art12

Qarriy Aina Urfiyya, Musa Fitri Fatkhiya, D. Perwitasari, S. Febriana, W. Supadmi

{"title":"Analisis biaya pasien Severe Cutaneous Adverse Reactions (SCARs)","authors":"Qarriy Aina Urfiyya, Musa Fitri Fatkhiya, D. Perwitasari, S. Febriana, W. Supadmi","doi":"10.20885/jif.vol18.iss2.art12","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art12","url":null,"abstract":"Latar belakang: Severe Cutaneous Adverse Reactions (SCARs) termasuk Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN) dan Drug Reaction with Eosinophilia and Systemic Symptom (DRESS), merupakan reaksi idiosinkratik yang paling sering disebabkan oleh obat yang berdampak pada peningkatan beban keuangan pasien.\u0000Tujuan: Penelitian ini bertujuan untuk mengetahui komponen biaya terbesar dan biaya perawatan pada pasien yang mengalami Severe Cutaneous Adverse Reactions (SCARs).\u0000Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Pengumpulan data biaya medik langsung, biaya non medik langsung dan biaya tidak langsung pada pasien rawat inap dengan SJS, TEN dan DRESS di RSUP Dr. Sardjito Yogyakarta tahun 2014-2018, secara retrospektif. Kami menghitung komponen biaya tertinggi dan biaya perawatan pasien dengan SCARs berdasarkan perspektif masyarakat.\u0000Hasil: Komponen biaya tertinggi pada pasien SJS dan TEN adalah biaya jasa profesional kesehatan (24,1% and 25,2%), sedangkan komponen biaya tertinggi pada pasien DRESS adalah biaya obat (20,2%). Total biaya perawatan 47 pasien SCARs (22 pasien SJS, 6 pasien TEN, dan 19 pasien DRESS) adalah Rp 666.615.321, dengan biaya rata-rata tertinggi pada pasien TEN, diikuti SJS dan DRESS (Rp 16.510.595, Rp 14.205.545, and Rp 13.445.555)\u0000Kesimpulan: Komponen biaya terbesar adalah biaya jasa professional kesehatan pada pasien SJS dan TEN, serta biaya obat bagi pasien DRESS. Penatalaksanaan SCARs membutuhkan biaya yang cukup besar, dan masih menjadi beban keuangan bagi pasien.","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89348081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skrining senyawa Eurycoma longifolia terhadap siklus sel dengan metode docking melalui interaksi cylcin 对细胞循环的欧氏肉瘤和细胞素相互作用的对接方法进行抽样检查

Kartika Jurnal Ilmiah Farmasi Pub Date : 2022-12-30 DOI: 10.20885/jif.vol18.iss2.art15

Samsul Hadi, Khoerul Anwar, Noer Komari, Desiya Ramayanti Azhara, D. Rosanti

{"title":"Skrining senyawa Eurycoma longifolia terhadap siklus sel dengan metode docking melalui interaksi cylcin","authors":"Samsul Hadi, Khoerul Anwar, Noer Komari, Desiya Ramayanti Azhara, D. Rosanti","doi":"10.20885/jif.vol18.iss2.art15","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art15","url":null,"abstract":"Latar belakang: Pasak bumi telah dikenal oleh masyarakat secara turun-temurun untuk meningkatkan gairah seksual pada pria (afrodisiaka). Disamping itu dapat meningkatkan performa atlet olahraga dan sebagai antistress, menurunkan tegangan, kemarahan, dan kebingungan. \u0000Tujuan: Penggunaan yang relatif banyak ini mendorong peneliti berkeinginan melakukan skrining senyawa aktif terhadap antitumor secara in silico dengan melalui 2 tahap yaitu melalaui PASS online dan docking. \u0000Metode: Metode docking dipakai untuk melihat interaksi stabilitas senyawa dengan cylin. Dalam pengujian ini, Pyrx digunakan sebagai alat docking dengan berbagai target yang berhubungan dengan siklus sel, yaitu cyclin D3 (PDB ID: 3G33), cyclin A (PDB ID: IJSU), cyclin C (PDB ID: 1ZP2), cyclin D (ID PDB: 2W9F), cyclin H (ID PDB: 1KXU), dan cyclin T (ID PDB: 3BLR). \u0000Hasil: Hasil docking pada masing-masing cyclin menunjukkan interaksi terbaik dengan senyawa berikut ini: cyclin A dan 9-Methoxycanthin-6-one 3-N-oxide (-8,6 Kkal/mol), cyclin H dan Niloticin (-8,0 Kkal/mol), cyclin D3 dan 9-Methoxycanthin-6-one 3-N-oxide (-7,2 Kkal/mol), cyclin D dan Eurycolactone F (-8,4 Kkal/mol), cyclin C dan Niloticin (-7,5 Kkal/mol), serta cyclin T dan Niloticin (-8,2 Kkal/mol). \u0000Kesimpulan: Berdasarkan skor docking yang diperoleh, kestabilan interaksi diprediksi akan terjadi pada cyclin A dengan 9-Methoxycanthin-6-one 3-N-oxide (delta G: -8.6 Kkal/mol).","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77687668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of single and combination chemotherapy agents in patients with metastatic breast cancer 转移性乳腺癌患者单一和联合化疗药物的评价

Kartika Jurnal Ilmiah Farmasi Pub Date : 2022-12-30 DOI: 10.20885/jif.vol18.iss2.art14

Martanty Aditya, Godeliva Adriani Hendra, Suhul Raos Kumawula Ing Gustyas

{"title":"Evaluation of single and combination chemotherapy agents in patients with metastatic breast cancer","authors":"Martanty Aditya, Godeliva Adriani Hendra, Suhul Raos Kumawula Ing Gustyas","doi":"10.20885/jif.vol18.iss2.art14","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art14","url":null,"abstract":"Background: There are several ways to treat breast cancer, one of which is administering chemotherapy agents. Chemotherapy agents have activity in inhibiting the cell cycle. That will affect the effectiveness of therapy and the side effects of chemotherapy agents.\u0000Objective: This study aimed to evaluate single and combination chemotherapy agent therapeutic efficacy and side effects\u0000Method: The design of this study used an observational cohort study with retrospective data collection from January to December 2019. Patients obtained from medical records were diagnosed with metastatic stage of breast cancer at Panti Nirmala Hospital, Malang. The effectiveness of the chemotherapy agent was seen from the carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3), which were carried out in the first and third cycles, then analyzed using the Wilcoxon and U-Mann Whitney tests. Side effects of chemotherapy agents were analyzed descriptively.\u0000Results: Analysis of the Wilcoxon test showed differences between the two groups of chemotherapeutic agents in CEA and CA15-3 (p<0.05). U-Mann Whitney test analysis showed no difference after administration of the two groups of chemotherapy agents at CEA (p>0.05). However, there was a difference in CA15-3 (p<0.05). Both chemotherapy agents showed most common side effects such as pain, nausea, vomiting, and alopecia.\u0000Conclusion: Patients who received a combination of chemotherapy agents had lower CA15-3 levels than single chemotherapy agents.","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77066401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potensi Enzim Superoksida Dismutase dari Biji Jagung (Zea Mays L.) untuk Perbaikan Sel Fibroblas 3t3 Yang Dipaparkan Sinar Ultraviolet A

Kartika Jurnal Ilmiah Farmasi Pub Date : 2022-12-30 DOI: 10.20885/jif.vol18.iss2.art16

Mustika Endah Pratiwi, Jason Merari Peranginangin, Isna Jati Asiya, Ana Indrayati

{"title":"Potensi Enzim Superoksida Dismutase dari Biji Jagung (Zea Mays L.) untuk Perbaikan Sel Fibroblas 3t3 Yang Dipaparkan Sinar Ultraviolet A","authors":"Mustika Endah Pratiwi, Jason Merari Peranginangin, Isna Jati Asiya, Ana Indrayati","doi":"10.20885/jif.vol18.iss2.art16","DOIUrl":"https://doi.org/10.20885/jif.vol18.iss2.art16","url":null,"abstract":"Latar belakang: Radiasi sinar UV-A memicu gangguan pada kulit yang disebut fotoaging. Fotoaging ditangani dengan zat antioksidan. SOD merupakan antioksidan enzimatis lini pertama dalam penanganan radikal bebasTujuan: Tujuan dari penelitian ini adalah untuk mengetahui aktifitas antifotoaging ekstrak SOD biji jagung pada sel fibroblas 3T3 yang dipaparkan sinar UV-A.Metode: Ekstraksi SOD biji jagung dilakukan menggunakan metode sentrifugasi, presipitasi dan dialisis. Aktivitas SOD dari ekstrak SOD biji jagung dilakukan dengan menggunakan metode WST-1. Aktivitas antifotoaging ekstrak SOD biji jagung dilakukan pada sel fibroblas 3T3 yang dipaparkan sinar UV-A dengan parameter viabilitas sel. Pengujian aktivitas antifotoaging menggunakan kontrol sel, kontrol negatif, sampel dan kontrol positif. Hasil pengukuran aktivitas antifotoaging ekstrak SOD biji jagung dianalisis menggunakan One Way ANOVA dengan uji Tukey.Hasil: Persen inhibisi aktivitas SOD tertinggi yaitu pada ekstrak SOD biji jagung presipitasi amonium sulfat konsentrasi 60-90%. Aktivitas antifotoaging ekstrak SOD biji jagung menunjukkan perbedaan bermakna pada nilai persen viabilitas sel pada sel fibroblas antara kelompok ekstrak dengan kelompok kontrol negatif dengan hasil persen viabilitas sel tertinggi yaitu pada ekstrak SOD biji jagung konsentrasi 100 mg/ml. Nilai EC90 untuk parameter viabilitas sel yaitu sebesar 12,57 mg/ml dan 69,47 mg/ml.Kesimpulan: Ekstrak SOD dari biji jagung terbukti memiliki aktivitas sebagai antioksidan yang dapat digunakan sebagai anti fotoaging melalui mekanisme perbaikan sel fibroblast.Kata kunci : Biji jagung, antifotoaging, kolagen, SOD, sel fibroblas 3T3","PeriodicalId":32369,"journal":{"name":"Kartika Jurnal Ilmiah Farmasi","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80051574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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