REVIEW: RANDOMIZED CLINICAL TRIAL STUDY OF INFLUENZA VACCINE IN CHILDREN AGE 6-35 MONTHS

Abstract

AbstractBackground: Influenza is a contagious viral infection disease that causes acute disorders of the respiratory tract. The prevalence of infection due to influenza virus is higher in children than adults. Thus, it is very important to vaccinate children using the most effective type of vaccine.Tujuan: The purpose of this review was to investigate type of influenza vaccine with the highest effectiveness in children aged 6-35 months based on Randomized Control Trial study.Method: The review is carried out by collecting articles from Elsevier and Medline database using “Influenza Vaccine”, “Randomized Control Trial”, and “Children” as the keywords.Results: Based on the initial searching, it was found 6.261 articles and 9 articles that fulfill the review criteria. The results showed that the best vaccine efficacy has gotten by trivalent vaccines against the strains of viruses A (H1N1), A (H3N2), and B (Yamagata) with vaccine efficacy values of 94.1%; 100%; and 97.1%, respectively. While the use of quadrivalent vaccines against strain B (Victoria) virus with a vaccine efficacy value of 87.2%.Conclusion: Trivalent vaccine more effective for strain A and B (Yamagata) virus, moreover quadrivalent vaccine more effective for strain B (Victoria)Keyword: Influenza, Vaccine, Children, Trivalent, Quadrivalent AbstrakLatar Belakang: Influenza merupakan suatu penyakit infeksi virus menular yang mengakibatkan gangguan akut pada saluran pernapasan. Insidensi infeksi akibat virus influenza lebih tinggi terjadi pada anak-anak dibanding dewasa. Dengan demikian, sangat penting untuk memberikan vaksinasi pada anak-anak menggunakan jenis vaksin yang paling efektif.Tujuan: Tujuan dari review ini adalah untuk menentukan jenis vaksin influenza dengan efektivitas tertinggi terhadap anak usia 6-35 bulan berdasarkan hasil studi Randomized Control Trial.Metode: Review dilakukan dengan penelusuran pustaka pada database ELSEVIER dan MEDLINE dengan kata kunciInfluenza Vaccine Randomized Control Trial Children.Hasil: Berdasarkan hasil penelusuran, diperoleh 6.261 artikel dan 9 artikel yang memenuhi kriteria review. Hasil telaah menunjukkan efektivitas vaksin terbaik pada vaksin trivalent terhadap virus strain A (H1N1), A (H3N2), dan B (Yamagata) dengan nilai efikasi vaksin secara berurutan sebesar 94,1%; 100%; dan 97,1%. Sedangkan penggunaan vaksin quadrivalent terhadap virus strain B (Victoria) dengan nilai efikasi vaksin 87,2%.Kesimpulan: Vaksin trivalent lebih efektif pada virus strain A dan B (Yamagata), sedangkan vaksin quadrivalent lebih efektif pada strain B (Victoria)Kata kunci: Influenza, Vaksin, Anak-anak, Trivalent, Quadrivalent