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THE EFFECT OF YB-1 PROTEIN IN СHIMERIC MODEL OF ALZHEIMER’S DISEASE yb-1蛋白在老年痴呆症Сhimeric模型中的作用
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.10
N. V. Bobkova, R. Poltavtseva, Daria Zhdanova, V. Kovalev, A. Chaplygina
{"title":"THE EFFECT OF YB-1 PROTEIN IN СHIMERIC MODEL OF ALZHEIMER’S DISEASE","authors":"N. V. Bobkova, R. Poltavtseva, Daria Zhdanova, V. Kovalev, A. Chaplygina","doi":"10.47501/978-5-6044060-1-4.10","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.10","url":null,"abstract":"The paper focuses on the molecular cell interaction of human mesenchymal stromal cells with the hippocampal primary culture of transgenic XFAD mice and the effect of multifunctional YB-1 protein on the memory and state of adult neurogenesis niches in animals with a chi-meric model of Alzheimer's disease. The results suggest the usefulness of a comprehensive use of cell therapy in combination with YB-1 to activate compensatory mechanisms in patients with Alzheimer's disease.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"2017 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127540877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STUDY OF THE TRANSFORMATION OF NITROSYL IRON COMPLEX WITH N-ETHYLTHIOUREA LIGANDS IN MODEL BIOLOGICAL SYSTEMS 亚硝基铁配合物与n -乙基硫脲配体在模式生物系统中的转化研究
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.52
O. Pokidova, N. Emel'yanova, A. Kulikov, A. Kotelnikov, N. Sanina
{"title":"STUDY OF THE TRANSFORMATION OF NITROSYL IRON COMPLEX WITH N-ETHYLTHIOUREA LIGANDS IN MODEL BIOLOGICAL SYSTEMS","authors":"O. Pokidova, N. Emel'yanova, A. Kulikov, A. Kotelnikov, N. Sanina","doi":"10.47501/978-5-6044060-1-4.52","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.52","url":null,"abstract":"The process of transformation of a mononuclear cationic complex with N-ethylthiourea ligands in Tris-HCl buffer, as well as in a reaction mixture with reduced glutathione and bovine serum albumin, has been studied. It was found that in the presence of glutathione, the complex dimer-izes, while its initial ligands are replaced by glutathione. In the presence of albumin, the decay product of the complex is coordinated with amino acid residues (Cys34 and His39) to form a protein-bound complex.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121571424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SPECIALIZED FOOD PRODUCT WITH HYPOCHOLESTEROLEMIC AND HYPOGLYCEMIC EFFECT: TECHNOLOGY AND COMPOSITION CHARACTERIZATION 具有降胆固醇降血糖作用的专用食品:工艺及成分表征
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.27
A. Kochetkova, N. Petrov, Valentina Matveevna Vorobyеva, Irina Sergeevna Vorobyеva, N. Biryulina, S. Zorin, V. Mazo
{"title":"SPECIALIZED FOOD PRODUCT WITH HYPOCHOLESTEROLEMIC AND HYPOGLYCEMIC EFFECT: TECHNOLOGY AND COMPOSITION CHARACTERIZATION","authors":"A. Kochetkova, N. Petrov, Valentina Matveevna Vorobyеva, Irina Sergeevna Vorobyеva, N. Biryulina, S. Zorin, V. Mazo","doi":"10.47501/978-5-6044060-1-4.27","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.27","url":null,"abstract":"The paper presents the technology and composition of a specialized food product for persons with disorders of carbohydrate and lipid metabolism with the inclusion of a functional food ingredient of hypoglycemic and hypocholesterolemic action - a complex of bilberry polyphenols sorbed on buckwheat flour.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130431598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DYNAMIC MORPHOLOGICAL CHANGES IN THE THYROID GLAND ASSOCIATED WITH DEPLETION OF DEUTERIUM BODY CONTENT 甲状腺的动态形态学改变与氘体含量的消耗有关
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.18
E. Timokhina, N. Yaglova, S. Obernikhin, V. Yaglov
{"title":"DYNAMIC MORPHOLOGICAL CHANGES IN THE THYROID GLAND ASSOCIATED WITH DEPLETION OF DEUTERIUM BODY CONTENT","authors":"E. Timokhina, N. Yaglova, S. Obernikhin, V. Yaglov","doi":"10.47501/978-5-6044060-1-4.18","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.18","url":null,"abstract":"Dynamics of morphological changes in the thyroid gland of mice, consuming water with lower deuterium content, was studied. Primary changes in structure were indicative of more active hormone secretion. Later morphological signs of inhibited hormone secretion were found. The findings demonstrate sensitivity of thyroid cells to shifts in deuterium body con-tent.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114219048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
APPLICATION OF INFORMATION TECHNOLOGIES IN THE WORK OF THE CENTER FOR PROMOTING EMPLOYMENT OF GRADUATES OF THE FSBEI VO KUBSMU OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION 信息技术在促进俄罗斯联邦卫生部联邦大学毕业生就业中心工作中的应用
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.41
Sergei Nikolaevich Alekseenko, T. Gaivoronskaya, Saida Kazbekovna Aкhedzhak-Naguze
{"title":"APPLICATION OF INFORMATION TECHNOLOGIES IN THE WORK OF THE CENTER FOR PROMOTING EMPLOYMENT OF GRADUATES OF THE FSBEI VO KUBSMU OF THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION","authors":"Sergei Nikolaevich Alekseenko, T. Gaivoronskaya, Saida Kazbekovna Aкhedzhak-Naguze","doi":"10.47501/978-5-6044060-1-4.41","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.41","url":null,"abstract":"The use of modern information technologies in the work of the Center for Assisting the Em-ployment of Graduates of the FSBEI HE KubSMU of the Ministry of Health of Russia pro-motes active interaction with local authorities, enterprises and organizations to achieve effective assistance in the employment of students and graduates, residents and graduate students.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"188 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116528147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INTEGRATED USE OF NATURAL INSECT RAW MATERIALS I'M IN. 综合利用天然昆虫原料。
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.35
Y. Savanina
{"title":"INTEGRATED USE OF NATURAL INSECT RAW MATERIALS I'M IN.","authors":"Y. Savanina","doi":"10.47501/978-5-6044060-1-4.35","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.35","url":null,"abstract":"The article discusses the possibility of using migratory locust as a resource - a seasonal, but abundant and predictable, possible source of fodder protein, as well as chitin and its deriva-tives. Comparison with traditional resources of such raw materials.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124014299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ROLE OF VNTR POLYMORPHIMS OF THE GENES ANTAGONIST OF RECEPTOR OF INTERLEIKINE 1 (IL1RN) AND INTERLEIKINE 4 (IL4) IN CARIES DEVELOPMENT IN CHILDREN 白细胞介素1 (il1rn)和白细胞介素4 (il4)受体拮抗剂基因VNTR多态性在儿童龋齿发育中的作用
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.01
I. Udina, Y. Vasilyev, V. Volobuev, A. Gracheva, O. Gulenko
{"title":"ROLE OF VNTR POLYMORPHIMS OF THE GENES ANTAGONIST OF RECEPTOR OF INTERLEIKINE 1 (IL1RN) AND INTERLEIKINE 4 (IL4) IN CARIES DEVELOPMENT IN CHILDREN","authors":"I. Udina, Y. Vasilyev, V. Volobuev, A. Gracheva, O. Gulenko","doi":"10.47501/978-5-6044060-1-4.01","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.01","url":null,"abstract":"Association of VNTR polymorphisms of two cytokine genes – antagonist of receptor of interleikine 1 (IL1RN) rs2234663 and interleikine 4 (IL4) rs8179190 with dental caries was studied in three groups of chidren with DFC (decompensated form of caries) with average age 10.19±0.54, with SFC (subcompensated form of caries) (11.66±0.46) and with CFC (compensated form of caries) and healthy (12.08±0.38). The genotypes with two “long” alleles L/L by IL1RN were demonstrated mediating resistance to highly active form of caries, and genotypes: A1/A2 P2/P2 and A2/A2 P2/P2 - susceptibility.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122879945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
METAL BINDING BY HEMOGLOBIN AT DIFFERENT CONDITIONS 血红蛋白在不同条件下的金属结合
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.45
A. Topunov, O. Kosmachevskaya, N. Novikova
{"title":"METAL BINDING BY HEMOGLOBIN AT DIFFERENT CONDITIONS","authors":"A. Topunov, O. Kosmachevskaya, N. Novikova","doi":"10.47501/978-5-6044060-1-4.45","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.45","url":null,"abstract":"The fact of the formation of additional binding centers of transition metal ions (Zn and Fe) in hemoglobin under conditions simulating endogenous intoxication was revealed. A mechanism for the emergence of such additional centers was proposed.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"187 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127355633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ROLE OF PREGNAN-X-RECEPTOR IN CELL RESISTANCE TO NITROSATIVE AND OXIDATIVE STRESS 妊娠- x受体在细胞抗亚硝化和氧化应激中的作用
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.47
Y. Abalenikhina, E. A. Sudakova, P. Erokhina, A. Shchulkin, E. Yakusheva
{"title":"ROLE OF PREGNAN-X-RECEPTOR IN CELL RESISTANCE TO NITROSATIVE AND OXIDATIVE STRESS","authors":"Y. Abalenikhina, E. A. Sudakova, P. Erokhina, A. Shchulkin, E. Yakusheva","doi":"10.47501/978-5-6044060-1-4.47","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.47","url":null,"abstract":"The article discusses the new role of pregnane X receptor (PXR) under conditions of oxidative and nitrosative stress. The results showed that the effect of hydrogen peroxide and S-nitrosoglu-tathione in high concentrations on Caco-2 cells leads to a decrease in cell viability, which is accompanied by an increase in the amount of PXR. These changes are offset by the addition of ketoconazole (inhibitor of PXR) to the medium.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116421874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FORMATION OF ORGANIZATIONAL AND MANAGEMENT ACTIVITIES OF GRADUATES OF A MEDICAL UNIVERSITY 医科大学毕业生组织管理活动的形成
Institute of information technology Pub Date : 1900-01-01 DOI: 10.47501/978-5-6044060-1-4.40
S. Akhedzhak-Naguze
{"title":"FORMATION OF ORGANIZATIONAL AND MANAGEMENT ACTIVITIES OF GRADUATES OF A MEDICAL UNIVERSITY","authors":"S. Akhedzhak-Naguze","doi":"10.47501/978-5-6044060-1-4.40","DOIUrl":"https://doi.org/10.47501/978-5-6044060-1-4.40","url":null,"abstract":"The use of modern innovative approaches to the formation of organizational and managerial activities of graduates of a medical university, based on the introduction of new achievements in science and technology, aimed at the formation of competencies in demand by society, increases the quality of graduate training.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129082956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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