ROLE OF VNTR POLYMORPHIMS OF THE GENES ANTAGONIST OF RECEPTOR OF INTERLEIKINE 1 (IL1RN) AND INTERLEIKINE 4 (IL4) IN CARIES DEVELOPMENT IN CHILDREN

Institute of information technology Pub Date : 1900-01-01 DOI:10.47501/978-5-6044060-1-4.01

I. Udina, Y. Vasilyev, V. Volobuev, A. Gracheva, O. Gulenko

引用次数: 0

Abstract

Association of VNTR polymorphisms of two cytokine genes – antagonist of receptor of interleikine 1 (IL1RN) rs2234663 and interleikine 4 (IL4) rs8179190 with dental caries was studied in three groups of chidren with DFC (decompensated form of caries) with average age 10.19±0.54, with SFC (subcompensated form of caries) (11.66±0.46) and with CFC (compensated form of caries) and healthy (12.08±0.38). The genotypes with two “long” alleles L/L by IL1RN were demonstrated mediating resistance to highly active form of caries, and genotypes: A1/A2 P2/P2 and A2/A2 P2/P2 - susceptibility.

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白细胞介素1 (il1rn)和白细胞介素4 (il4)受体拮抗剂基因VNTR多态性在儿童龋齿发育中的作用

在三组平均年龄为10.19±0.54岁的DFC(失代偿型龋齿)、SFC(亚代偿型龋齿)(11.66±0.46)、CFC(代偿型龋齿)和健康(12.08±0.38)的儿童中，研究了两种细胞因子基因-白细胞介素1受体拮抗剂(IL1RN) rs2234663和interleikine 4 (IL4) rs8179190的VNTR多态性与龋病的关系。具有两个“长”等位基因L/L的IL1RN基因型可介导高活性形式的龋病抗性，基因型为A1/A2 P2/P2和A2/A2 P2/P2 -易感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Institute of information technology

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