I. Udina, Y. Vasilyev, V. Volobuev, A. Gracheva, O. Gulenko
{"title":"白细胞介素1 (il1rn)和白细胞介素4 (il4)受体拮抗剂基因VNTR多态性在儿童龋齿发育中的作用","authors":"I. Udina, Y. Vasilyev, V. Volobuev, A. Gracheva, O. Gulenko","doi":"10.47501/978-5-6044060-1-4.01","DOIUrl":null,"url":null,"abstract":"Association of VNTR polymorphisms of two cytokine genes – antagonist of receptor of interleikine 1 (IL1RN) rs2234663 and interleikine 4 (IL4) rs8179190 with dental caries was studied in three groups of chidren with DFC (decompensated form of caries) with average age 10.19±0.54, with SFC (subcompensated form of caries) (11.66±0.46) and with CFC (compensated form of caries) and healthy (12.08±0.38). The genotypes with two “long” alleles L/L by IL1RN were demonstrated mediating resistance to highly active form of caries, and genotypes: A1/A2 P2/P2 and A2/A2 P2/P2 - susceptibility.","PeriodicalId":302576,"journal":{"name":"Institute of information technology","volume":"38 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ROLE OF VNTR POLYMORPHIMS OF THE GENES ANTAGONIST OF RECEPTOR OF INTERLEIKINE 1 (IL1RN) AND INTERLEIKINE 4 (IL4) IN CARIES DEVELOPMENT IN CHILDREN\",\"authors\":\"I. Udina, Y. Vasilyev, V. Volobuev, A. Gracheva, O. Gulenko\",\"doi\":\"10.47501/978-5-6044060-1-4.01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Association of VNTR polymorphisms of two cytokine genes – antagonist of receptor of interleikine 1 (IL1RN) rs2234663 and interleikine 4 (IL4) rs8179190 with dental caries was studied in three groups of chidren with DFC (decompensated form of caries) with average age 10.19±0.54, with SFC (subcompensated form of caries) (11.66±0.46) and with CFC (compensated form of caries) and healthy (12.08±0.38). The genotypes with two “long” alleles L/L by IL1RN were demonstrated mediating resistance to highly active form of caries, and genotypes: A1/A2 P2/P2 and A2/A2 P2/P2 - susceptibility.\",\"PeriodicalId\":302576,\"journal\":{\"name\":\"Institute of information technology\",\"volume\":\"38 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Institute of information technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47501/978-5-6044060-1-4.01\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Institute of information technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47501/978-5-6044060-1-4.01","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
ROLE OF VNTR POLYMORPHIMS OF THE GENES ANTAGONIST OF RECEPTOR OF INTERLEIKINE 1 (IL1RN) AND INTERLEIKINE 4 (IL4) IN CARIES DEVELOPMENT IN CHILDREN
Association of VNTR polymorphisms of two cytokine genes – antagonist of receptor of interleikine 1 (IL1RN) rs2234663 and interleikine 4 (IL4) rs8179190 with dental caries was studied in three groups of chidren with DFC (decompensated form of caries) with average age 10.19±0.54, with SFC (subcompensated form of caries) (11.66±0.46) and with CFC (compensated form of caries) and healthy (12.08±0.38). The genotypes with two “long” alleles L/L by IL1RN were demonstrated mediating resistance to highly active form of caries, and genotypes: A1/A2 P2/P2 and A2/A2 P2/P2 - susceptibility.
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