妊娠- x受体在细胞抗亚硝化和氧化应激中的作用

Institute of information technology Pub Date : 1900-01-01 DOI:10.47501/978-5-6044060-1-4.47

Y. Abalenikhina, E. A. Sudakova, P. Erokhina, A. Shchulkin, E. Yakusheva

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引用次数: 0

摘要

本文讨论了妊娠X受体(PXR)在氧化和亚硝化应激条件下的新作用。结果表明，过氧化氢和高浓度的s -亚硝基谷胱甘肽对Caco-2细胞的作用导致细胞活力下降，并伴有PXR的增加。在培养基中加入酮康唑(PXR抑制剂)可抵消这些变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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ROLE OF PREGNAN-X-RECEPTOR IN CELL RESISTANCE TO NITROSATIVE AND OXIDATIVE STRESS

The article discusses the new role of pregnane X receptor (PXR) under conditions of oxidative and nitrosative stress. The results showed that the effect of hydrogen peroxide and S-nitrosoglu-tathione in high concentrations on Caco-2 cells leads to a decrease in cell viability, which is accompanied by an increase in the amount of PXR. These changes are offset by the addition of ketoconazole (inhibitor of PXR) to the medium.

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Institute of information technology

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