AME Case ReportsPub Date : 2024-11-21eCollection Date: 2025-01-01DOI: 10.21037/acr-24-138
Yanan Li, Kefeng Wu, Huiying Li, Chun Wu
{"title":"HER2 positive primary breast squamous cell carcinoma with good prognosis: a case report.","authors":"Yanan Li, Kefeng Wu, Huiying Li, Chun Wu","doi":"10.21037/acr-24-138","DOIUrl":"10.21037/acr-24-138","url":null,"abstract":"<p><strong>Background: </strong>Primary breast squamous cell carcinoma (PBSCC) is a unique histopathological type of breast cancer. The majority of current case reports of PBSCC are triple-negative tumors with poor prognosis. Due to its heterogeneous clinical course, no unified management is achieved. Here, we report a human epidermal growth factor receptor 2 (HER2) positive case with good clinical outcome, which may contribute to the development of appropriate guidelines and imprecise management of PBSCC.</p><p><strong>Case description: </strong>A 45-year-old female presented with a painless mass in the medial-upper quadrants of right breast and the imaging examination suggested a malignant tumor. She received modified radical mastectomy and axillary sentinel lymph node dissection of the right breast, and the pathological diagnosis was squamous cell carcinoma with HER2 over-expression. Subsequently, she underwent post-operative chemotherapy regimen of doxorubicin, cyclophosphamide, T-docetaxel and trastuzumab (AC-TH) and then received maintenance treatment with trastuzumab and pertuzumab. Clinical follow-up suggests that she had achieved clinical complete remission and has survived for over 4 years.</p><p><strong>Conclusions: </strong>The diagnosis of PBSCC relies on histomorphology, due to non-specific imaging manifestations. Immunohistochemical (IHC) staining helps to clarify the pathological type, hormone receptor status, HER2 amplification and programmed cell death ligand 1 (PD-L1) expression, which is essential for clinical decision-making. HER2-positive PBSCC patients can benefit from AC-TH chemotherapy and 1-year anti-HER2 therapy is necessary to good prognosis. If possible, dual anti-HER2 therapy combined with trastuzumab and pertuzumab is recommended. Finally, positive clinical prognosis of PBSCC may be attributed to early detection, immediate surgery, precise diagnosis and proper adjuvant treatment strategy.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"20"},"PeriodicalIF":0.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AME Case ReportsPub Date : 2024-11-18eCollection Date: 2025-01-01DOI: 10.21037/acr-24-93
Vraj Patel, Mina Rismani, Fakhra Sultan, Amr Essa, Pascha Schafer
{"title":"Electrical storm caused by sertraline overdose: case report.","authors":"Vraj Patel, Mina Rismani, Fakhra Sultan, Amr Essa, Pascha Schafer","doi":"10.21037/acr-24-93","DOIUrl":"10.21037/acr-24-93","url":null,"abstract":"<p><strong>Background: </strong>In cases of electrical storm, identifying the etiology is essential, as patients with reversible causes do not benefit from implantable cardioverter defibrillator (ICD). Given the diversity of pharmacologic and nonpharmacologic management tools available for hemodynamically unstable patients in electrical storm, all must be considered and tailored to each individual patient.</p><p><strong>Case description: </strong>This report describes a 36-year-old female without prior cardiac history who presented in ventricular fibrillation (VF) electrical storm. While she lacked significant electrolyte abnormalities or ischemia to explain etiology of electrical storm, she incidentally had variant coronary anatomy noted on angiography. After thorough consideration of possible etiologies of storm, selective serotonin reuptake inhibitor (SSRI) intoxication was the most highly suspected etiology. Regarding management of her hemodynamically unstable electrical storm, she was treated with lidocaine, amiodarone, as well as mechanical circulatory support devices including extracorporeal membrane oxygenation (ECMO) and intra-aortic balloon pump (IABP). The patient ultimately was decannulated from ECMO, had IABP removal, and achieved recovery of ejection fraction (EF) to baseline. She was not offered ICD as the etiology of her cardiac arrest was reversable. She was discharged with recommendation to discontinue SSRI and follow up with psychiatry regarding SSRI overdose.</p><p><strong>Conclusions: </strong>Identification of electrical storm etiology is crucial as reversible causes do not warrant ICD placement. Selection of appropriate pharmacologic and nonpharmacologic management in the hemodynamically unstable electrical storm patient is important given the wide range of available options.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"22"},"PeriodicalIF":0.7,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AME Case ReportsPub Date : 2024-11-14eCollection Date: 2025-01-01DOI: 10.21037/acr-24-119
Rongwei Xu, Linna Tang, Minghai Wang, Shiyong Qin, Shuguang Zhang
{"title":"Fluoroscopy-guided guidewire-assisted technique for difficult removal of a peripherally inserted central venous catheter (PICC) in children: a report of three cases and literature review.","authors":"Rongwei Xu, Linna Tang, Minghai Wang, Shiyong Qin, Shuguang Zhang","doi":"10.21037/acr-24-119","DOIUrl":"10.21037/acr-24-119","url":null,"abstract":"<p><strong>Background: </strong>In general, it is relatively easy to remove peripherally inserted central venous catheter (PICC) by gentle traction without any complications. However, the removal of PICC can be challenging occasionally. If the standard interventions fail to remove the catheter, there are no clear recommendations about what to do. We presented three cases to explore fluoroscopy-guided guidewire-assisted technique for removal of the firmly adherent PICC.</p><p><strong>Case description: </strong>Three cases of difficult PICC removal were all children with acute lymphoblastic leukemia (ALL). All cases were male, range 3-6 years, mean 5.00±1.73 years, catheter indwelling time 289-433 days, mean 367.33±72.83 days. All three cases underwent PICC intubation via the basilic vein approach and all catheters were 3.0 French (Fr), silicone, single-lumen PICCs (Bard Access Systems, Inc., Salt Lake City, UT, USA). Removal of the PICC at the end of the treatment course was difficult. The pullback of the catheter went smoothly for the first few centimeters, but then resistance was encountered. The catheter did not move backward at that point, although we applied strong continuous traction. Several noninvasive approaches to remove the catheter (e.g., repositioning of the extremity, application of hot compress, and vascular massage) were all with no success. Eventually, the firmly adherent PICC was removed using fluoroscopy-guided guidewire-assisted technique in hybrid operating room safely and successfully.</p><p><strong>Conclusions: </strong>Difficult PICC removal can result after prolonged dwell times. When conventional noninvasive interventions are unsuccessful, fluoroscopy-guided guidewire-assisted technique is a safe and effective method for the removal of adherent PICC.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"21"},"PeriodicalIF":0.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AME Case ReportsPub Date : 2024-11-13eCollection Date: 2025-01-01DOI: 10.21037/acr-24-81
Qinguo Liu, Deshou Ma, Yufei Wang, Xiaofeng Zhou, Lei Shen, Zhijun Ma
{"title":"Is classic papillary thyroid carcinoma definitely an \"indolent cancer\"?-a case of locally advanced classic occult papillary thyroid carcinoma: a case report.","authors":"Qinguo Liu, Deshou Ma, Yufei Wang, Xiaofeng Zhou, Lei Shen, Zhijun Ma","doi":"10.21037/acr-24-81","DOIUrl":"10.21037/acr-24-81","url":null,"abstract":"<p><strong>Background: </strong>Occult papillary thyroid carcinoma (PTC) refers to the PTC accidentally found due to its occult lesions. Classic, as the most common subtype of PTC, is usually considered to have a low degree of malignancy and a favorable prognosis. Currently, the American Thyroid Association Management Guidelines adopted active surveillance (AS) as an alternative to immediate surgery in some low-risk PTC patients with less than 1 cm in diameter.</p><p><strong>Case description: </strong>The patient was admitted to the clinic because of an incidentally detected right neck mass, and neck ultrasonography (US) and computed tomography (CT) showed an enlarged lymph node in right neck, which had an unclear border with the right internal jugular vein and the sternocleidomastoid muscle, whereas no abnormality was detected in thyroid glands; fine-needle aspiration biopsy (FNAB) of the enlarged lymph node showed metastatic carcinoma, and the possibility of follicular epithelial origin from the thyroid was highly considered; then the enlarged lymph node resection + right thyroid lobectomy + freezing + left thyroid lobectomy and isthmus resection + lymph nodes and adipose tissue dissection in II-VI regions in right neck + complete resection of the invaded right sternocleidomastoid muscle and right internal jugular vein were performed; postoperative pathology was classic PTC and lymph node metastasis with blood vessels and striated muscle tissues involved.</p><p><strong>Conclusions: </strong>In this case, lateral cervical lymph node metastasis had already occurred without the preoperative detection of a primary thyroid focus, suggesting that the potential risk of classic PTC <1 cm cannot be ignored. Besides, how to accurately identify the malignant degree of low-risk PTC <1 cm preoperatively is worthy of further study.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"10"},"PeriodicalIF":0.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AME Case ReportsPub Date : 2024-11-13eCollection Date: 2025-01-01DOI: 10.21037/acr-24-123
Waseem Jerjes, Rachel Kopunova
{"title":"Evaluating the risk of mild serotonin syndrome in primary care: a retrospective case series of patients with treatment-resistant depression.","authors":"Waseem Jerjes, Rachel Kopunova","doi":"10.21037/acr-24-123","DOIUrl":"10.21037/acr-24-123","url":null,"abstract":"<p><strong>Background: </strong>Serotonin syndrome is an adverse drug reaction characterised by the excess of serotonin activity in the central nervous system. It is a condition of great concern in primary care where some patients, usually with treatment-resistant depression, get treatment with multiple serotonergic agents.</p><p><strong>Case description: </strong>This retrospective case series looked at 20 primary care patients with treatment-resistant depression who developed mild serotonin syndrome after starting a second antidepressant. The patients were, on average, 40.4 years old, with 55% being female, and had been in treatment for about 5.3 years. The study also considered other health conditions and medications the patients were using. Interventions included stopping or reducing the dose of the second antidepressant, adjusting medications, and educating the patients. Symptoms occurred 1 to 4 weeks after introduction of the second antidepressant, with duration before presentation to the primary care physician ranging from 2 to 11 weeks. Symptoms resolved between 7-21 days after interventions for all patients, and 85% of cases were resolved in under 2 weeks. The most common intervention was stopping or reducing the dose of serotonergic medications in 70% of cases. All patients had improved, with an excellent response to well-targeted interventions in the primary care setting.</p><p><strong>Conclusions: </strong>This study highlights the need for careful monitoring of serotonin syndrome in patients with treatment-resistant depression, especially in the case of polypharmacy. Early recognition of symptoms by primary care providers and close management ensure patient safety through proper medication management and education.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"34"},"PeriodicalIF":0.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AME Case ReportsPub Date : 2024-11-13eCollection Date: 2025-01-01DOI: 10.21037/acr-24-110
Alexis M Dunn, Laura E Coats, Tulip A Jhaveri, Kamir Boodoo, Samantha Williams, Elizabeth A Lutz, Sarah Araji
{"title":"Brucellosis in pregnancy: a case report.","authors":"Alexis M Dunn, Laura E Coats, Tulip A Jhaveri, Kamir Boodoo, Samantha Williams, Elizabeth A Lutz, Sarah Araji","doi":"10.21037/acr-24-110","DOIUrl":"10.21037/acr-24-110","url":null,"abstract":"<p><strong>Background: </strong><i>Brucella</i> spp., a gram-negative bacterium, is one of the most prevalent zoonotic illnesses worldwide and is more commonly seen in animals; however, the disease may be present in humans. Clinical manifestations of brucellosis are variable and can range from asymptomatic to severe disease. In women who are pregnant, potential obstetrics complications are possible. The purpose of this report is to present a case of brucellosis in a pregnant patient and discuss the potential complications and treatment recommendations.</p><p><strong>Case description: </strong>We present a case of a 17-year-old gravida 2, parity 1 (G2P1) at 35 weeks and 2 days (35w2d) with brucellosis after she assisted in the delivery of puppies. All puppies were stillborn and the dog was confirmed positive for <i>B. canis</i> on serological testing. Our patient was also found to have <i>B. canis</i>, which is a particularly rare cause of human brucellosis. She was treated with ceftriaxone, rifampin, and gentamicin before delivery and switched to doxycycline and ceftriaxone postpartum until negative. The patient was instructed not to breastfeed. After treatment, the patient felt well and the baby was healthy.</p><p><strong>Conclusions: </strong>When evaluating patients, it is necessary to obtain a social history including animal exposures to rule in or rule out zoonotic infections such as brucellosis. It is important to establish a suspected brucellosis infection in pregnancy and begin antibiotic treatment as soon as possible to prevent maternal and fetal complications. The treatment regimen we administered was an effective strategy, particularly for pregnancy, when typical treatments are contraindicated.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"9"},"PeriodicalIF":0.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AME Case ReportsPub Date : 2024-11-13eCollection Date: 2025-01-01DOI: 10.21037/acr-24-97
Andrey Valerievich Ushakov
{"title":"A case report of unilateral development of painful thyroiditis used as a hallmark of the nervous nature of its pathogenesis.","authors":"Andrey Valerievich Ushakov","doi":"10.21037/acr-24-97","DOIUrl":"10.21037/acr-24-97","url":null,"abstract":"<p><strong>Background: </strong>Painful thyroiditis (PT) combines several variants of pathology. The most common is subacute thyroiditis (ST). Despite the prevailing view that the factors underlying the development of ST have an infectious origin, its viral and bacterial pathogeneses remain unclear. Moreover, the hypothesis of genetic predisposition to ST is non-absolute. In previous studies, approximately 24-40% patients with ST manifested unilateral thyroid disease; however, the assessment of the pathogenesis of ST did not consider this fact.</p><p><strong>Case description: </strong>This case of unilateral PT in a pregnant woman has become an illustrative example for revising the idea of its pathogenesis. Laboratory data did not show obvious signs of inflammation, which is typical for pregnant women and does not exclude ST. At the same time, rare in the literature illustrations of the ultrasound picture of unilateral PT are shown. Pathological parallels with other unilateral thyropathies have been drawn. A possible source of unilateral thyroid changes may be the nerve-conducting mechanism.</p><p><strong>Conclusions: </strong>The involvement of the nervous system in the inflammatory process and the possibility that unilateral nerve conduction affects only one of the thyroid lobes, as demonstrated in the present case, indicate that the autonomic nervous system (ANS) plays a leading role in PT development.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"13"},"PeriodicalIF":0.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AME Case ReportsPub Date : 2024-11-07eCollection Date: 2025-01-01DOI: 10.21037/acr-24-131
Jing Lin, Qingwei Ji, Ling Liu, Zongyan Huang, Yingxia Yang, Jie Shen
{"title":"Syncope secondary to arrhythmogenic left ventricular cardiomyopathy: a case report.","authors":"Jing Lin, Qingwei Ji, Ling Liu, Zongyan Huang, Yingxia Yang, Jie Shen","doi":"10.21037/acr-24-131","DOIUrl":"10.21037/acr-24-131","url":null,"abstract":"<p><strong>Background: </strong>Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disease characterized by fibrofatty replacement of ventricular myocardium. Ventricular arrhythmia and sudden cardiac death (SCD) are the main clinical manifestations. ACM was previously called arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). However, recent studies have shown that this disease is not limited to the right ventricle; biventricular involvement occurs in 50% of ACM patients. The left-dominant subtype was subsequently identified, which supported the adoption of the broader term \"ACM\". The clinical literature includes more extensive reports on ARVC, but reports on arrhythmogenic left ventricular cardiomyopathy (ALVC), which is likely to be underrecognized, are limited.</p><p><strong>Case description: </strong>In this report, we describe a case of secondary syncope in a patient with ALVC who developed right bundle branch block with ventricular tachycardia (RBBB-VT), with VT originating in the left ventricle (LV). Cardiac magnetic resonance (CMR) revealed significant enlargement of the LV, with LV dysfunction. Late gadolinium enhancement (LGE) and fat sequencing revealed that most of the free wall of the LV was replaced by fibrofatty tissue.</p><p><strong>Conclusions: </strong>This report could help improve the understanding of this rare disease, and its management. CMR plays a key role in the diagnosis of ACM.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"15"},"PeriodicalIF":0.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AME Case ReportsPub Date : 2024-11-07eCollection Date: 2025-01-01DOI: 10.21037/acr-23-115
Gabriel de Azambuja Beigin, Joao Henrique Godoy Rodrigues, Murillo de Souza Tuckumantel, Waldomiro Camargo, Ana Beatriz Souza de Oliveira, Abel Guilherme Rosa, Luis Cesar Fava Spessoto, Fernando Nestor Facio Júnior, Carlos Abib Cury
{"title":"Giant prostatic calculus in patient treated with perineal prostatotomy: case report.","authors":"Gabriel de Azambuja Beigin, Joao Henrique Godoy Rodrigues, Murillo de Souza Tuckumantel, Waldomiro Camargo, Ana Beatriz Souza de Oliveira, Abel Guilherme Rosa, Luis Cesar Fava Spessoto, Fernando Nestor Facio Júnior, Carlos Abib Cury","doi":"10.21037/acr-23-115","DOIUrl":"10.21037/acr-23-115","url":null,"abstract":"<p><strong>Background: </strong>Urolithiasis (kidney stone) is a common condition that often leads patients to urgent or emergency care services. Urinary calculi are generally found in the kidneys, ureters, or bladder. Urethral calculi are uncommon and can result from the migration of a calculus in the upper urinary tract or vesicle or may be primary of the urethra. Prostatic calculi are a rarity.</p><p><strong>Case description: </strong>A 34-year-old male was admitted to the emergency service of a university hospital reporting dysuria and pain in the hypogastrium with a 4-day history. The patient reported that the pain sometimes irradiated to the left flank, accompanied by micturition effort, a weak urinary stream, pollakiuria, and urine output with a crystal appearance. The clinical history revealed urinary difficulty since 10 years of age. The patient was submitted to radiological investigation. Pelvic computed tomography revealed a voluminous calculus with slightly lobulated contours in the intravesical topography in the interior of the prostatic urethra. Urethrocystography revealed a prostatic calculus and the tapered passage of contrast through the prostatic urethra. After the diagnosis, the rectal examination confirmed the presence of a hardened calculous mass in the prostatic topography. Considering the complementary evaluation of the patient, perineal prostatotomy was planned. Prostatotomy was performed longitudinally in the prostatic capsule for the removal of the calculus after its release by dissection.</p><p><strong>Conclusions: </strong>In cases of patients with urinary retention treated at an emergency service, the following diagnostic hypotheses should be investigated: benign hyperplasia of the prostate, urethral stenosis, prostatic urethral calculus, and prostatic calculus. In prostatic calculus, regarding access for definitive surgery, in this case, the perineal route proved to be the best therapeutic option.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"12"},"PeriodicalIF":0.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AME Case ReportsPub Date : 2024-11-06eCollection Date: 2025-01-01DOI: 10.21037/acr-24-8
Daniele S C Ramsay, Harvey Stevenson, Waseem Jerjes
{"title":"Auditory hallucinations induced by atorvastatin and exacerbated by cefalexin: a rare case report.","authors":"Daniele S C Ramsay, Harvey Stevenson, Waseem Jerjes","doi":"10.21037/acr-24-8","DOIUrl":"10.21037/acr-24-8","url":null,"abstract":"<p><strong>Background: </strong>Auditory hallucinations, commonly associated with psychiatric conditions such as schizophrenia, can arise as side effects to certain medications. Several drug classes are commonly implicated in the causation of hallucinations, such as anticholinergics. Medication associated with disruption of steroid production may lead to neuropsychiatric disruption. One such drug class, statins, may also have psychiatric sequelae. Wide prescribing of common medication such as atorvastatin, allows the unveiling of uncommon medication-related adverse events.</p><p><strong>Case description: </strong>We detail a unique case-report of a 60-year-old man experiencing auditory hallucinations post-initiation of atorvastatin. The content of the hallucinations consisted of voices of deceased family members. These were frequently accompanied by predominantly frontal headaches. Subsequently, during the treatment of a chest infection utilizing cefalexin, the auditory hallucinations intensified in clarity and increased in frequency. Despite initial concerns related to a family history of meningiomas, magnetic resonance imaging ruled out structural abnormalities. Comprehensive viral screening excluded infectious as the causative factor and there were no signs of concurrent delirium. Following termination of the course of cefalexin, the hallucinations reduced in intensity. The cessation of atorvastatin led to the resolution of hallucinations.</p><p><strong>Conclusions: </strong>This case emphasizes the importance of drug history evaluation in neuropsychiatric presentations and prompts further exploration into the neuropsychiatric effects of commonly prescribed drugs.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"11"},"PeriodicalIF":0.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}