AME Case Reports最新文献

{"title":"A rare case of mycosis fungoides with porokeratosis-like lesions: a case report and review of previous literature.","authors":"Salim S Alkeraye, Turky N Alsehli, Ahmed Alhumidi, Khalid Al-Husain, Khalid Nabil Nagshabandi","doi":"10.21037/acr-24-210","DOIUrl":"https://doi.org/10.21037/acr-24-210","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous T-cell lymphomas (CTCLs) are the second most prevalent group of extranodal lymphomas second to B-cell lymphomas. Mycosis fungoides (MF) is the most common type of CTCL, often presenting as erythematous patches and plaques with scaling. However, MF is known for its wide range of clinical presentations, making it a \"great mimicker\" of other dermatological conditions. It can manifest as hypopigmented, hyperkeratotic, or purpuric lesions, among others, contributing to frequent diagnostic challenges. Porokeratosis-like MF is an exceedingly rare variant, with only a few cases reported in the literature. This case report describes a unique presentation of MF mimicking porokeratosis.</p><p><strong>Case description: </strong>A 44-year-old male presented with brownish papules on the feet, showing porokeratosis-like features upon clinical presentation. Histopathological examination and immunohistochemistry revealed a profile consistent with MF, demonstrating band-like infiltrate of lymphocytes in the papillary dermis and CD7 loss and CD8 positivity in both the epidermis and dermis. The patient was treated with topical Clobetasol propionate, showing partial improvement over a biweekly follow-up period of three months with no recurrence observed to date.</p><p><strong>Conclusions: </strong>This case underscores the importance of considering MF in atypical porokeratosis presentations. A thorough clinicopathologic correlation is vital for accurate diagnosis and management of such unusual MF variants.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"67"},"PeriodicalIF":0.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of misdiagnosis and mistreatment of 11 cases of non-tuberculous testicular abscess: case series.","authors":"Yanmei Li, Zhuorui Zhang, Liangyun Zhao","doi":"10.21037/acr-24-222","DOIUrl":"https://doi.org/10.21037/acr-24-222","url":null,"abstract":"<p><strong>Background: </strong>Non-tuberculous testicular abscess is primarily a late-stage development complication of urological inflammation. As the disease progresses, some cases' imaging, laboratory results, and clinical symptoms are not typical enough, which frequently results in delayed treatment or a misdiagnosis that necessitates a non-essential orchiectomy. We analyze and summarize the data related to the surgical treatment of non-tuberculous testicular abscesses diagnosed in our hospital in order to help with the clinical diagnosis of related diseases and the choice of treatment. This is done through the analysis and summary of the pertinent data on the diagnosis of non-tuberculous testicular abscess for surgical treatment at our hospital.</p><p><strong>Case description: </strong>Clinical information for 11 patients with testicular abscesses who were diagnosed for surgical treatment in our hospital between 2006 and 2023 was retrospectively examined. Out of the eleven patients with nontuberculous testicular abscesses who had postoperative testicular pathology confirm the diagnosis, five had imaging-diagnosed testicular infarcts, two received orchiectomy due to misdiagnosis of testicular tumors, and one had an incorrect diagnosis of testicular torsion.</p><p><strong>Conclusions: </strong>Non-tuberculous testicular abscesses can present with a wide range of unusual clinical signs, making a diagnosis difficult to make. In order to reduce the risk of orchiectomy and testicular atrophy, the foundation of clinical therapeutic decision-making is to obtain a precise diagnosis whenever feasible and to intervene as soon as necessary with incision and decompression.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"38"},"PeriodicalIF":0.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case series of adult Wilms' tumor and review of the literature.","authors":"Ying He, Fan Yang, Qi Gao, Yu Xiang, Zhong Chen, Xiaoqin Chen, Yang Luan","doi":"10.21037/acr-24-208","DOIUrl":"https://doi.org/10.21037/acr-24-208","url":null,"abstract":"<p><strong>Background: </strong>Adult Wilms' tumor (AWT) is extremely rare in clinics and very difficult to diagnose preoperatively. However, a unified treatment plan of AWT is lacking and the prognosis is unfavorable. This study will present the follow-up data of AWT cases in Tongji Hospital and discuss the diagnosis, treatment, and prognosis of AWT.</p><p><strong>Case description: </strong>The clinical data of four AWT cases admitted to the Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from August 2010 to January 2019 were followed up and analyzed. The mean age of the three males and one female patients was 38 years old. One case was admitted due to lumbar and abdominal distension, one case due to renal occupancy found on routine physical examination, and the other two cases due to lumbar pain with painless gross hematuria. The tumors were 4-10 cm in size, three of which were confined to the kidney, and one case invaded the inferior vena cava. Four cases were treated surgically: three with radical nephrectomy and one with partial nephrectomy. Two cases were treated with postoperative adjuvant chemotherapy (one case received the actinomycin D + vincristine regimen and pirarubicin + vincristine regimen; another case was treated with etoposide + carboplatin and cyclophosphamide + vincristine + adriamycin), and the other two cases were received postoperative follow-up only. Similar cases were reviewed in the literature. According to the postoperative pathology, one case was AWT germ type, two cases were AWT epithelial type, and one case was AWT mixed type. Two cases were classified in stage I, one case in stage II, and one case in stage III. All cases were followed up over 5 years, with two deaths and two survivals and a mean progression-free survival of 39 months.</p><p><strong>Conclusions: </strong>AWT is a relatively rare malignant tumor with a low preoperative diagnostic accuracy and a poorer prognosis than children. Early diagnosis, successful surgery, and standardized postoperative adjuvant therapy according to pathological typing and staging are the key points to improve the survival of AWT patients.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"39"},"PeriodicalIF":0.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report of high-grade B-cell lymphoma with <i>MYC</i> and <i>BCL2</i> rearrangements presenting as compartment syndrome of the leg.","authors":"Xin Wang, Noureldien Darwish, Xiaoyan Huang","doi":"10.21037/acr-24-154","DOIUrl":"https://doi.org/10.21037/acr-24-154","url":null,"abstract":"<p><strong>Background: </strong>Diffuse large B-cell lymphoma (DLBCL)/high-grade B-cell lymphoma with MYC and BCL2 rearrangements (\"double-hit\" lymphoma) is an uncommon subtype of mature B-cell lymphoma characterized by the concurrent rearrangements of MYC and BCL2 oncogenes. Rarely, aggressive high-grade lymphomas manifest as compartment syndrome, necessitating urgent surgical intervention. Here, we describe a case of high-grade B-cell lymphoma with an unusual presentation of compartment syndrome.</p><p><strong>Case description: </strong>A 68-year-old woman presented to the emergency room with increased swelling and pain in her right leg, was subsequently diagnosed with right thigh compartment syndrome, and underwent urgent fasciotomy followed by repeat debridement in the medical wound closure. Additionally, the patient was found to have inguinal and external iliac lymphadenopathy along with deep vein thrombosis (DVT). Her past medical history included human immunodeficiency virus (HIV) infection, which was well-controlled with bictegravir, emtricitabine, and tenofovir alafenamide. Excisional biopsy of the right thigh muscle and fluorescence in situ hybridization (FISH) analysis confirmed the diagnosis of high-grade B-cell lymphoma with <i>MYC</i> and <i>BCL2</i> gene rearrangements arising in the setting of immunodeficiency/dysregulation (lymphoma associated with HIV infection). Despite aggressive medical management in the intensive care unit, the patient succumbed to the disease and ultimately died from sepsis and hemorrhagic shock.</p><p><strong>Conclusions: </strong>High-grade B-cell lymphoma with MYC and BCL2 rearrangements represents an aggressive lymphoma with a poor prognosis. The unusual manifestation of this lymphoma involving skeletal muscle and presenting as compartment syndrome is rare. Unfortunately, the patient passed away shortly after undergoing debridement surgery. This case highlights the importance for clinicians to be vigilant and attentive to atypical presentations, as delays in diagnosis and treatment can have significant consequences. Early recognition and prompt intervention are crucial in saving the patient's life.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"62"},"PeriodicalIF":0.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difficult insertion of a transesophageal echocardiography probe for cardiac surgery not only before but also immediately after thyroid goiter resection in a patient with chronic esophageal compression by the goiter: a case report.","authors":"Masataka Fukuda, Tsukasa Kochiyama, Kota Aono, Shuhei Yonemoto, Megumi Hayashi, Masakazu Hayashida, Izumi Kawagoe","doi":"10.21037/acr-24-241","DOIUrl":"https://doi.org/10.21037/acr-24-241","url":null,"abstract":"<p><strong>Background: </strong>Transesophageal echocardiography (TEE) is an essential tool during minimally invasive cardiac surgery (MICS), although inserting a TEE probe is sometimes challenging. We experienced difficult placement of an adult TEE probe for cardiac surgery due to chronic compression of the esophagus by thyroid goiter. The aim of this case report is to highlight the challenges of TEE probe insertion due to chronic esophageal compression caused by a thyroid goiter and to discuss considerations for simultaneous thyroid tumor resection and mitral valvuloplasty (MVP).</p><p><strong>Case description: </strong>A 78-year-old man (170 cm, 68 kg) with severe mitral regurgitation (MR) was scheduled for simultaneous thyroid surgery and MVP, since preoperatively, experienced cardiologists had failed to place an adult TEE probe for preoperative TEE examinations, and they had had to use a pediatric TEE probe with poor image quality. First, otolaryngologists completely resected the left thyroid lobe including goiter. However, even after tumor resection, experienced anesthesiologists could not advance the adult TEE probe beyond the pharynx due to strong resistance, even using video laryngoscopy to visualize the esophageal inlet. Again, they had to use a pediatric probe for intraoperative evaluation.</p><p><strong>Conclusions: </strong>Such previously unreported experiences suggested that esophageal stenosis due to chronic compression by goiter would not improve completely at least immediately after tumor resection. When usual TEE probe placement is difficult, alternative methods for assessing the mitral valve (MV) should be considered.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"63"},"PeriodicalIF":0.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late Lyme neuroborreliosis with predominant myelitis in a patient with neuropsychiatric presentation: a case report.","authors":"Sandra Duong, Nicole Rudolph, Sabine Majer","doi":"10.21037/acr-24-202","DOIUrl":"https://doi.org/10.21037/acr-24-202","url":null,"abstract":"<p><strong>Background: </strong>Late Lyme neuroborreliosis (LNB) can develop gradually over months or years. Diagnosis can be very difficult, resulting in treatment delay and higher risk of sequelae. By publishing this case report, we hope to highlight the difficulties associated with Lyme disease in a patient with assumed psychosomatic disorder.</p><p><strong>Case description: </strong>We present the case of a 54-year-old patient with late LNB presenting predominantly with myelitis. The patient suffered from symptoms for more than 1.5 years before a diagnosis was made through testing of cerebrospinal fluid (CSF) samples and magnetic resonance imaging (MRI) of the spine. MRI revealed signs of a long ranging myelopathy with a dull signal alteration in the spinal cord. CSF samples displayed lympho-monocytic pleocytosis, plasma cells and Borrelia-specific intrathecal antibodies. The long delay before diagnosis and ultimately the start of antibiotic treatment was likely influenced by the initial attribution of symptoms to psychosomatic causes.</p><p><strong>Conclusions: </strong>LNB presents with variable and often nonspecific symptoms, making diagnosis difficult. Early warning signs may be overlooked, especially in patients with comorbidities or psychiatric history. Treatment delay increases the risk of residual symptoms. This case highlights the difficulties surrounding LNB and underlines the importance of an individualized and thorough diagnostic approach, regardless of pre-existing conditions.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"59"},"PeriodicalIF":0.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two missense mutations in Dystonin lead to epidermolysis bullosa simplex complicated with lepromatous leprosy: a case report.","authors":"Lina Al-Quran, Guiyue Cai, Rongyi Chen, Yongfeng Chen","doi":"10.21037/acr-24-167","DOIUrl":"https://doi.org/10.21037/acr-24-167","url":null,"abstract":"<p><strong>Background: </strong>Epidermolysis bullosa (EB) is a severe, single-gene hereditary skin condition characterized by blisters, bullae, and erosion following minor trauma. Epidermolysis bullosa simplex (EBS), one of the four major types of EB, is typically caused by mutations in the <i>KRT5</i> or <i>KRT14</i> genes. However, mutations in the Dystonin (<i>DST</i>) gene, which is also involved in maintaining skin integrity, can lead to EBS. This study aims to report a unique case of EBS caused by two novel heterozygous mutations in the <i>DST</i> gene, complicated by lepromatous leprosy (LL), a chronic infectious disease caused by <i>Mycobacterium leprae</i> (M. leprae). These mutations, not previously reported in the literature, expand the known spectrum of <i>DST</i>-related EBS and highlight the importance of comprehensive diagnostic approaches in patients with complex skin conditions.</p><p><strong>Case description: </strong>This report describes a 32-year-old man presented with erythema, blisters and yellow nodules on his limbs, initially diagnosed as bullous pemphigoid (BP). Over time, his symptoms evolved to include features of LL and erythema nodosum leprosum (ENL), a severe inflammatory reaction often associated with leprosy. Further genetic testing revealed two missense mutations in the <i>DST</i> gene: c.5972A>G(p.Asn1991Ser) and c.5137A>G(p.Asn1713Asp). Both variants were predicted to be damaging by in silico analyses and are rare in population databases. The patient was diagnosed with EBS that causes the skin to be very fragile and blister easily. The combination of EBS, LL and ENL is rare.</p><p><strong>Conclusions: </strong>This case highlights EBS caused by <i>DST</i> mutations, emphasizing the importance of comprehensive diagnostic workup in patients with bullous diseases. Additionally, it underscores the importance of rational glucocorticoid use and careful skin wound care in treating bullous skin diseases.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"49"},"PeriodicalIF":0.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An extremely rare case of Rosai-Dorfman-Destombes disease in the spleen with secondary thrombocytopenia: a case report.","authors":"Xiqi Liu, Cheng Quan, Yu Wang","doi":"10.21037/acr-24-207","DOIUrl":"https://doi.org/10.21037/acr-24-207","url":null,"abstract":"<p><strong>Background: </strong>Rosai-Dorfman-Destombes disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, multisystemic histiocytic disorder. It can affect multiple organs, including bones, the brain, nasal cavities, and breasts. But, RDD in the spleen with secondary thrombocytopenia is extremely rare. This report aimed to show some new symptoms to help in the early diagnosis of this disease.</p><p><strong>Case description: </strong>A 68-year-old female patient presented with abdominal discomfort for over 2 months. Positron emission tomography-computed tomography (PET-CT) examination revealed multiple splenic lesions with no significant abnormalities elsewhere. The patient had a history of rheumatoid arthritis and diabetes. Physical examination showed no significant abnormalities. Blood tests upon admission revealed a platelet count of 39×10⁹ cells/L. An elective laparoscopic splenectomy was performed in April 2024. Postoperative pathology and immunohistochemistry suggested RDD. Based on the lab reports and clinical manifestations, the patient was diagnosed with splenic primary RDD with secondary thrombocytopenia. The patient was followed up regularly, and the platelet level recovered to 222×10⁹ cells/L 1-month post-surgery, confirming the cause of thrombocytopenia as secondary to splenic RDD. No significant abnormalities were found on abdominal CT 5 months post-surgery. Preoperative diagnosis of RDD remains challenging, especially for abdominal primary RDD, as percutaneous biopsy is difficult and imaging studies lack specific features, making the diagnosis still dependent on postoperative pathology and immunohistochemistry.</p><p><strong>Conclusions: </strong>This case indicates that in patients with multiple splenic space-occupying lesions and thrombocytopenia, particularly with a history of rheumatoid arthritis, the potential for this illness should be contemplated, even in the absence of conventional RDD lymph node symptoms.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"57"},"PeriodicalIF":0.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilomatricoma of the breast similar to breast cancer on ultrasound and elastography: a case report.","authors":"Shuanglian Zhu, Nianyu Xue","doi":"10.21037/acr-24-103","DOIUrl":"https://doi.org/10.21037/acr-24-103","url":null,"abstract":"<p><strong>Background: </strong>Pilomatricoma, also known as calcifying epithelioma of Malherbe, is a benign tumor originating from human hair follicle stem cells and commonly observed in adolescents. Pilomatricomas can arise in any region with hair follicles, typically presenting as solitary lesions, predominantly affecting the facial region. Clinically, they manifest as firm, painless nodules, with both pathological and ultrasonographic findings often revealing calcifications. We report a rare case of pilomatricoma located on the breast, which exhibits characteristics are similar to breast cancer. Combining with ultrasound and elastography may provide some references for clinical diagnosis.</p><p><strong>Case description: </strong>We report a case of pilomatricoma located on the 47-year-old female breast, characterized by multiple punctate hyperechoic foci internally, presenting as a firm, non-tender mass on palpation and elastography. Without seeking treatment, she experienced pain in the lump two weeks before presentation. After applying an unspecified anti-inflammatory ointment, the lump markedly increased. Therefore, the rapid enlargement of the mass within a short period raised clinical suspicion of breast cancer, leading to surgical excision, which subsequently confirmed pilomatricoma through histopathological examination.</p><p><strong>Conclusions: </strong>Pilomatricomas occurring on the breast may present clinically and ultrasonographically similar to breast cancer, necessitating a focus on distinguishing between the two entities based on layer-derived differentiation on ultrasound and elastography.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"46"},"PeriodicalIF":0.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chorioretinal involvement in a patient with paracoccidioidomycosis: a case report.","authors":"Adriano Cypriano Faneli, Pamella Consonni Morello, Pedro Fernandes Souza Neto, Ricardo Danilo Chagas Oliveira, Cristina Muccioli","doi":"10.21037/acr-24-201","DOIUrl":"https://doi.org/10.21037/acr-24-201","url":null,"abstract":"<p><strong>Background: </strong>Paracoccidioidomycosis is a systemic fungal infection endemic to Latin America, with limited reports of ocular involvement. This case is unique for presenting chorioretinal lesions without vision loss, highlighting the importance of ophthalmologic evaluation in patients diagnosed with Paracoccidioidomycosis. Early antifungal treatment is crucial for preventing severe outcomes.</p><p><strong>Case description: </strong>A 58-year-old male, previously diagnosed with Paracoccidioidomycosis through a skin biopsy, presented with palpebral lesions and mild keratitis in the right eye (OD) and chorioretinal lesions in the left eye (OS) upon fundoscopic examination. Optical coherence tomography (OCT) of macula revealed characteristic chorioretinal lesions in the OS, indicative of a fungal infection. Despite the ocular findings, visual acuity remained unaffected. Diagnosis was established based on the patient's medical history of fungal infection, epidemiology, and ophthalmological findings. The patient was treated with systemic Amphotericin B followed by sulfamethoxazole-trimethoprim that resulted in notable improvements either in the palpebral cutaneous lesions of the OD and the chorioretinal lesion observed in OS.</p><p><strong>Conclusions: </strong>This case highlights the critical role of ophthalmologic evaluation in diagnosing and managing rare complications of systemic paracoccidioidomycosis. Early intervention with appropriate systemic antifungal therapy can significantly improve outcomes, preserving vision and mitigating systemic complications. Enhanced awareness among clinicians in endemic areas is essential for timely diagnosis and management.</p>","PeriodicalId":29752,"journal":{"name":"AME Case Reports","volume":"9 ","pages":"55"},"PeriodicalIF":0.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}