Carbohydrate Polymers最新文献_第2页

Chitosan/oxidized cellulose composite nanofiber sponges: a rapid and effective hemostasis strategy for non-compressible hemorrhage 壳聚糖/氧化纤维素复合纳米纤维海绵：一种快速有效的非压缩性出血止血策略

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-24 DOI: 10.1016/j.carbpol.2025.123655

Zhan Zhang , Zhiyuan Lin , Chenglong Yu , San Ieng Lei , Lu Wang , Fujun Wang , Jing Gao , Wenbo Meng

{"title":"Chitosan/oxidized cellulose composite nanofiber sponges: a rapid and effective hemostasis strategy for non-compressible hemorrhage","authors":"Zhan Zhang , Zhiyuan Lin , Chenglong Yu , San Ieng Lei , Lu Wang , Fujun Wang , Jing Gao , Wenbo Meng","doi":"10.1016/j.carbpol.2025.123655","DOIUrl":"10.1016/j.carbpol.2025.123655","url":null,"abstract":"<div><div>Non-compressible hemorrhagic wounds, prevalent in combat and mass trauma scenarios, are characterized by arterial injury-induced exsanguination and geometrically complex wound morphology that challenges conventional hemostatic interventions. This paper presents a novel nanofiber hemostatic sponge (CT@GP-HAc), made from 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) oxidized cellulose nanofibers (TOCN) and chitosan nanofibers (CSNF), crosslinked with genipin (GP) in an acetic acid atmosphere. The sponge features excellent shape memory and rapid hemostatic capabilities, specifically designed for deep, irregular wounds. Its unique micro-nano composite porous structure enhances blood absorption, blood cell capture, and coagulation factor recruitment. In vitro experiments show that CT@GP-HAc outperforms traditional iRegene® GEL sponges in whole blood coagulation index, coagulation time, and red blood cell and platelet adhesion. Prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) tests reveal that CT@GP-HAc's hemostatic action is independent of the human coagulation mechanism, making it suitable for patients with coagulation disorders. Biocompatibility tests indicate an extremely low hemolysis rate and non-cytotoxicity, supporting its clinical application. In vivo studies confirm CT@GP-HAc's effectiveness in reducing blood loss and shortening hemostasis time. These findings highlight the potential of CT@GP-HAc as a next-generation hemostatic material for managing non-compressible hemorrhagic wounds.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"361 ","pages":"Article 123655"},"PeriodicalIF":10.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High toughness, high stability and low hysteresis PVA /HPMC/PA/SBMA/ZnCl2 conductive hydrogels for wearable flexible electronics for multifunctional sensors and supercapacitors 高韧性、高稳定性、低迟滞PVA /HPMC/PA/SBMA/ZnCl2导电水凝胶，用于多功能传感器和超级电容器的可穿戴柔性电子产品

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-24 DOI: 10.1016/j.carbpol.2025.123644

Fan Wang , HuaQing Zhang , ChunLing Liu , Wen Bao , YaJuan Hu , Xieraili Maimaitiyiming

{"title":"High toughness, high stability and low hysteresis PVA /HPMC/PA/SBMA/ZnCl2 conductive hydrogels for wearable flexible electronics for multifunctional sensors and supercapacitors","authors":"Fan Wang , HuaQing Zhang , ChunLing Liu , Wen Bao , YaJuan Hu , Xieraili Maimaitiyiming","doi":"10.1016/j.carbpol.2025.123644","DOIUrl":"10.1016/j.carbpol.2025.123644","url":null,"abstract":"<div><div>PVA-based conductive hydrogels have enormous potential for applications in wearable flexible electronic devices, but their low ionic conductivity and mechanical strength hinder their practical utility. To address this challenge, we propose a PVA-based incorporating metal salt and zwitterion. We use PA(phytic acid) and HPMC (hydroxypropyl methylcellulose) - compatible properties to prepare PSBMA<sub>1</sub>-PMAZ<sub>1.5</sub> interpenetrating conductive hydrogel with good electrical signal responsiveness, repeatability, compression resistance, and low hysteresis (≤11.68 %). The hydrogel-based flexible strain sensor has a wide detection range, high sensitivity (GF = 1.1 at 0 − 600 %), stable electrical signal response to variations in temperature and humidity, and human movement detection capabilities. The detection range of hydrogel - based supercapacitors is 25 °C - 40 °C, which indicates that the device assembled with activated carbon as the electrode has good capacitance characteristics, and the multifunctional characteristics of PSBMA<sub>1</sub>-PMAZ<sub>1.5</sub> hydrogels are poised to serve as a demonstration for a new generation of flexible electronic products.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"361 ","pages":"Article 123644"},"PeriodicalIF":10.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Antibacterial and flame-retardant TEMPO-oxidized cellulose nanofibrils/chitosan-based sponge for efficient PM2.5 capture 抗菌阻燃tempo氧化纤维素纳米纤维/壳聚糖基海绵，高效捕获PM2.5

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-24 DOI: 10.1016/j.carbpol.2025.123642

Yifan Chen , Shite Lin , Weisheng Han , Youwen Chen , Qijun Zhang , La Hu , Wenbiao Zhang , Jingda Huang

{"title":"Antibacterial and flame-retardant TEMPO-oxidized cellulose nanofibrils/chitosan-based sponge for efficient PM2.5 capture","authors":"Yifan Chen , Shite Lin , Weisheng Han , Youwen Chen , Qijun Zhang , La Hu , Wenbiao Zhang , Jingda Huang","doi":"10.1016/j.carbpol.2025.123642","DOIUrl":"10.1016/j.carbpol.2025.123642","url":null,"abstract":"<div><div>PM2.5, which can carry many bacteria, poses a serious threat to health when inhaled. Therefore, developing porous materials with efficient filtration and antibacterial properties is essential for preventing the invasion of PM2.5 on respiratory health. In this study, we designed a multifunctional sponge filter through the synergistic integration of TEMPO-oxidized cellulose nanofibrils (TCNF), chitosan (CS), graphene oxide (GO), and lignin hybrid particles. A robust three-dimensional network was constructed via amide cross-linking between TCNF and CS, endowing the sponge with exceptional mechanical stability. GO enhances the PM2.5 interception efficiency through electrostatic adsorption. Additionally, we introduce lignin nanoparticles (LNP) as carriers for growing zinc oxide (ZnO), forming organic-inorganic hybrid particles (LNP@ZnO). This approach minimizes the negative impact of ZnO on the mechanical properties of the sponge while enhancing antibacterial performance. The resulting sponge filter demonstrates high PM2.5 filtration efficiency (99.14 %) with low pressure drop (38 Pa), excellent antibacterial properties against <em>E. coli</em> (92.63 %) and <em>S. aureus</em> (89.05 %), and outstanding flame-retardant properties (LOI value of 27.1 %). This study addresses the limitations of existing systems by minimizing the trade-off between antibacterial performance and mechanical strength, offering a novel approach for the design of advanced air filtration materials.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"361 ","pages":"Article 123642"},"PeriodicalIF":10.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel multifunctional self-assembled nanocellulose based scaffold for the healing of diabetic wounds 一种新型多功能自组装纳米纤维素支架用于糖尿病伤口愈合

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-24 DOI: 10.1016/j.carbpol.2025.123643

Guangrui Ma , Lina Fu , Hao Wang , Wenqi Yin , Pengyu He , Zhijun Shi , Guang Yang

{"title":"A novel multifunctional self-assembled nanocellulose based scaffold for the healing of diabetic wounds","authors":"Guangrui Ma , Lina Fu , Hao Wang , Wenqi Yin , Pengyu He , Zhijun Shi , Guang Yang","doi":"10.1016/j.carbpol.2025.123643","DOIUrl":"10.1016/j.carbpol.2025.123643","url":null,"abstract":"<div><div>The healing of chronic diabetic wounds remains a key challenge due to its susceptibility to bacterial infection, the inflammatory wound microenvironment, and difficulty in angiogenesis. Herein, we devised a smart scaffold of nanocellulose with silk fibroin-loaded cerium oxide nanoparticles for the treatment of diabetic wounds. The smart scaffold dressing displays excellent porosity, water absorption, air permeability, water retention, controlled degradability, and antioxidant properties. In vitro experiments demonstrated that the scaffold was capable of promoting the degradation of the scaffolds through uncross linking and exhibited antibacterial activity against both Gram-positive (<em>S. aureus</em>) and Gram-negative (<em>E. coli</em>) bacteria. Furthermore, in vivo experiments showed that smart scaffold dressing can reduces inflammation at the wound site of diabetic mice and promote collagen deposition, angiogenesis and re-epithelialization during wound healing in diabetic mice, exhibiting favorable biocompatibility and biodegradability. Its efficacy surpassed that of the current commercially available membrane dressings (3 M dressings) and medical PELNAC dressings (Class III medical device). These findings suggest that the smart scaffold dressing is a promising and innovative dressing for the treatment of diabetic wounds.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"361 ","pages":"Article 123643"},"PeriodicalIF":10.7,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of different high amylose starch granules. Part III: How starch fine structures affect retrogradation and formation of type 3 resistant starch 不同高直链淀粉颗粒的表征。第三部分：淀粉精细结构如何影响3型抗性淀粉的退化和形成

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-23 DOI: 10.1016/j.carbpol.2025.123633

Li Ding , Jiyu Yang , Jacob Judas Kain Kirkensgaard , Kasper Enemark-Rasmussen , Jinhui Chang , Lude Zhang , Sheng Chen , Andreas Blennow , Yuyue Zhong

{"title":"Characterization of different high amylose starch granules. Part III: How starch fine structures affect retrogradation and formation of type 3 resistant starch","authors":"Li Ding , Jiyu Yang , Jacob Judas Kain Kirkensgaard , Kasper Enemark-Rasmussen , Jinhui Chang , Lude Zhang , Sheng Chen , Andreas Blennow , Yuyue Zhong","doi":"10.1016/j.carbpol.2025.123633","DOIUrl":"10.1016/j.carbpol.2025.123633","url":null,"abstract":"<div><div>The effects of amylose (AM) content (AC) and starch fine structures on the retrogradation and type 3 resistant starch (RS3) formation were investigated using seven starches with various fine structures and ACs ranging from 27 % to 97 %. RS3 contents ranged from 31.9 % to 50.3 %, without a linear increase with AC. However, thermally stable RS3 contents obtained through reheating increased with AC before plateauing at 57 %, ranging from 18.3 % to 39.5 %. Retrograded amylopectin (AP), AM-lipid complexes, and retrograded AM crystals were identified. Notably, as AC reached 57 %, a transition from AP to AM retrogradation was observed. Greater retrogradation degree and structural order induced higher RS3. Retrograded AP, AM-lipid complexes, and retrograded AM were likely composed of AP chains with degree of polymerization (DP) 13–24, AM chains with DP 500–5000, and short AM chains with DP < 500, respectively. RS3 in these HASs comprised a mixture of double-helical and single-helical structures, with their levels likely enhanced by increasing amounts of AM chains with DP < 5000 and AP chains with DP > 36, respectively. These findings provided insights into developing functional foods with desired retrogradation degree and RS3 by controlling AC and fine structures of AM and AP.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"361 ","pages":"Article 123633"},"PeriodicalIF":10.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143868306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and characterization of microcapsules using an acid-tolerant sanxan gum combined with sodium alginate/chitosan and their application in Lactobacillus plantarum delivery 海藻酸钠/壳聚糖复合耐酸三原胶微胶囊的制备、表征及其在植物乳杆菌中的应用

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-23 DOI: 10.1016/j.carbpol.2025.123638

Yue Ming , Zhuangzhuang Shi , Yufei Zhao , Jue Li , Wei Sha , Weilong Wang , Guoqiang Li , Mengmeng Wu , Ting Ma

{"title":"Preparation and characterization of microcapsules using an acid-tolerant sanxan gum combined with sodium alginate/chitosan and their application in Lactobacillus plantarum delivery","authors":"Yue Ming , Zhuangzhuang Shi , Yufei Zhao , Jue Li , Wei Sha , Weilong Wang , Guoqiang Li , Mengmeng Wu , Ting Ma","doi":"10.1016/j.carbpol.2025.123638","DOIUrl":"10.1016/j.carbpol.2025.123638","url":null,"abstract":"<div><div>The oral delivery of probiotics faces numerous challenges, particularly the acidic gastric environment. This study aimed to construct microcapsules using acid-resistant polysaccharide sanxan gum (SG) combined with sodium alginate (SA) and chitosan (CS), and to evaluate their protective effects on the probiotic bacteria <em>Lactobacillus plantarum</em> (<em>Lp</em>) during in vitro simulated gastrointestinal digestion. Sanxan gum, an edible polysaccharide produced by <em>Sphingomonas sanxanigenens</em> strain, is composed of mannose, glucuronic acid, rhamnose, and glucose. Sodium alginate has been widely used to protect probiotics because it is cheap, safe, and easy to form into microcapsules. Chitosan is a cationic polysaccharide with excellent mucoadhesive properties and film-forming capabilities. Herein, the microcapsules were prepared using the extrusion drop method. Compared with microcapsules based solely on sodium alginate, those with a ratio of sanxan gum to sodium alginate of 4:6 demonstrated enhanced encapsulation efficiency (97.66 ± 0.79 %) and freeze-dried cell viability (9.97 ± 0.03 log CFU/g). Furthermore, the incorporation of chitosan yielded the highest encapsulation efficiency for the <em>Lp</em>@SG-SA@CS microcapsules (99.14 ± 1.46 %) and significantly enhanced their tolerance to heat, bile salts, and gastric acid. Our findings suggest that sanxan gum can confer acid resistance to microcapsules, highlighting its potential for applications in diverse acidic environments.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"361 ","pages":"Article 123638"},"PeriodicalIF":10.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Konjac glucomannan/Bletilla striata polysaccharide composite hydrogel: A promising anti-inflammatory dressing for accelerated wound healing 魔芋葡甘露聚糖/白芨多糖复合水凝胶：一种有前途的抗炎敷料，加速伤口愈合

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-23 DOI: 10.1016/j.carbpol.2025.123639

Yanchao Hao , Jiapu Wang , Hao Zhang , Qi Liu , Xin Wang , Yan Wei , Ziwei Liang , Yinchun Hu , Di Huang

{"title":"Konjac glucomannan/Bletilla striata polysaccharide composite hydrogel: A promising anti-inflammatory dressing for accelerated wound healing","authors":"Yanchao Hao , Jiapu Wang , Hao Zhang , Qi Liu , Xin Wang , Yan Wei , Ziwei Liang , Yinchun Hu , Di Huang","doi":"10.1016/j.carbpol.2025.123639","DOIUrl":"10.1016/j.carbpol.2025.123639","url":null,"abstract":"<div><div>A hydrogel with remarkable anti-inflammatory properties holds significant potential for accelerating wound healing. This study focuses on developing a safe and effective wound-healing hydrogel based on polysaccharides. The hydrogel was synthesized by cross-linking Konjac Glucomannan (KGM) and <em>Bletilla Striata</em> Polysaccharide (BSP) using 1,4-Butanediol Diglycidyl Ether (BDDE) and subsequently evaluated as a wound dressing. Compared to hydrogels cross-linked solely with KGM, the co-crosslinked KGM-BSP hydrogel demonstrated superior water retention, enhanced mechanical strength (maximum tensile stress: 6.6 kPa), excellent adhesive properties (maximum shear stress: 848.53 ± 31.4 Pa), and outstanding biocompatibility.</div><div>Moreover, <em>in vitro</em> anti-inflammatory assays revealed that the KGM-BSP hydrogel effectively inhibited the activation of the TNF-α/NF-κB pathway while upregulating IL-10 expression, thereby mitigating inflammation and facilitating tissue repair during wound healing. Scratch and Western blot assays further indicated that the hydrogel significantly enhanced the migratory capacity of L929 cells by activating the Rho GTPase pathway.</div><div>In a mouse wound model, the KGM-BSP hydrogel reduced inflammation, promoted angiogenesis, and stimulated collagen deposition, collectively accelerating wound closure. These findings suggest that the KGM-BSP composite hydrogel is a highly promising wound dressing with the potential to markedly enhance the wound healing process.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"361 ","pages":"Article 123639"},"PeriodicalIF":10.7,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoporous carboxymethyl cellulose aerogels with enhanced thermal insulation and mechanical toughness 具有增强隔热和机械韧性的纳米多孔羧甲基纤维素气凝胶

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-22 DOI: 10.1016/j.carbpol.2025.123634

Yufan Yang , Shanying Sui , Yufang Lu , Jingxing Wang , Yuhan Sheng , Yi Zhang , Zhifang Sun

引用次数: 0

Hempseed cell wall polysaccharides are dominated by linear xylans and cellulose: Comprehensive structural profiling of ten cultivars of industrial hemp, Cannabis sativa L. 大麻细胞壁多糖以线状木聚糖和纤维素为主：10个工业大麻品种的综合结构分析。

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-22 DOI: 10.1016/j.carbpol.2025.123635

Prakash Raj Pandeya , Ian M. Black , Steven D. Karlen , Christian Heiss , Yen-Chang Tseng , A. Bruce Downie , Parastoo Azadi , Rachel R. Schendel

{"title":"Hempseed cell wall polysaccharides are dominated by linear xylans and cellulose: Comprehensive structural profiling of ten cultivars of industrial hemp, Cannabis sativa L.","authors":"Prakash Raj Pandeya , Ian M. Black , Steven D. Karlen , Christian Heiss , Yen-Chang Tseng , A. Bruce Downie , Parastoo Azadi , Rachel R. Schendel","doi":"10.1016/j.carbpol.2025.123635","DOIUrl":"10.1016/j.carbpol.2025.123635","url":null,"abstract":"<div><div>Hempseed is a rich source of dietary fiber; however, there has been limited research on the variability of carbohydrate composition in hempseed cell walls. The primary aim of this study was to conduct a comprehensive chemical and structural analysis of the cell wall polysaccharides in ten hempseed cultivars. Water-soluble polysaccharides (WSP) and water-insoluble residues (WIR) were isolated and subsequently analyzed for their monosaccharide composition using HPAEC-PAD, glycosyl linkage analysis using GC–MS, and structural characterization via NMR spectroscopy. All hempseed cultivars contained a high proportion of insoluble fibers and smaller amounts of soluble polysaccharides. Glucose and xylose were the most abundant components of the WIR fractions, while the WSP fractions contained abundant amounts of galactose, galacturonic acid, arabinose, rhamnose, and mannose. The results of linkage and spectroscopic analysis were consistent with the compositional analysis, identifying cellulose and acetylated linear xylans as primary components of WIR, and arabinogalactans, rhamnogalacturonans, heteromannans, xyloglucans, and arabinan as predominant in WSP. Overall, the study revealed a comparable cell wall structure among the analyzed hemp seed varieties. The high fiber content of whole hempseed-based ingredients presents significant potential for food manufacturers seeking to develop products with enhanced dietary fiber content, offering both functional and nutritional benefits for consumers.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"361 ","pages":"Article 123635"},"PeriodicalIF":10.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poly(lactide acid)-based microneedles enhanced by tunicate cellulose nanocrystals for potential diabetic periodontitis treatment 由束状纤维素纳米晶体增强的聚乳酸基微针用于潜在的糖尿病牙周炎治疗

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2025-04-22 DOI: 10.1016/j.carbpol.2025.123629

Yang Yang , Gengyu Zhou , Yang Chen , Ning Lin , Jingzhi Ma

{"title":"Poly(lactide acid)-based microneedles enhanced by tunicate cellulose nanocrystals for potential diabetic periodontitis treatment","authors":"Yang Yang , Gengyu Zhou , Yang Chen , Ning Lin , Jingzhi Ma","doi":"10.1016/j.carbpol.2025.123629","DOIUrl":"10.1016/j.carbpol.2025.123629","url":null,"abstract":"<div><div>Diabetic periodontitis, characterized by persistent inflammation and impaired periodontal tissue regeneration under hyperglycemic conditions, urgently requires innovative therapeutic strategies. Microneedle (MN) technique has recently emerged as a promising solution for diabetic periodontitis by enabling minimally invasive and localized drug delivery. In this study, we developed poly(lactic acid) (PLA)-based MNs reinforced with PLA-grafted tunicate cellulose nanocrystals (TCNC-g-PLA@PLA-MNs), demonstrating favorable mechanical strength and biocompatibility. After loading with irisin and interleukin-1 (IL-1) receptor antagonist (IL-1ra) via surface polydopamine functionalization, the MNs exhibited anti-inflammatory effects by markedly reducing the expressions of IL-6 by 0.53-fold, IL-8 by 0.23-fold, and MCP-1 by 0.41-fold in human periodontal ligament cells (hPDLCs). Additionally, they significantly promoted osteogenic differentiation, increasing the expressions of ALP by 1.87-fold, OPN by 2.21-fold, OCN by 1.39-fold, and Runx2 by 2.28-fold, which was further supported by enhanced ALP staining. Furthermore, the MNs improved the migration ability of hPDLCs under inflammatory and high-glucose culture conditions. Our findings highlight that the TCNC-g-PLA@PLA-MNs effectively integrate structural reinforcement and therapeutic functionality, providing a novel and potential platform to promote periodontal regeneration in the context of diabetic periodontitis.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"361 ","pages":"Article 123629"},"PeriodicalIF":10.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0