Eliane Leal de Lara , Matheus Zavadinack , Shayane da Silva Milhorini , Karin Maciel Wurzer , Giseli Klassen , Lucimara M.C. Cordeiro , Marcello Iacomini
{"title":"Structural characterization and anticancer properties of a novel mushroom-derived rhamnogalactan in a triple-negative breast cancer model","authors":"Eliane Leal de Lara , Matheus Zavadinack , Shayane da Silva Milhorini , Karin Maciel Wurzer , Giseli Klassen , Lucimara M.C. Cordeiro , Marcello Iacomini","doi":"10.1016/j.carbpol.2025.123735","DOIUrl":"10.1016/j.carbpol.2025.123735","url":null,"abstract":"<div><div>Mushroom-derived polysaccharides are known for their diverse biological activities, including immunomodulatory and anticancer properties. Breast cancer, the leading cause of cancer-related death among women worldwide, lacks targeted molecular therapies, underscoring the need for novel therapeutic agents. In this study, we extracted, purified, and characterized a novel heteropolysaccharide (HTP) - a rhamnogalactan - composed of galactose (72.6 %) and rhamnose (27.4 %) from the edible mushroom <em>Lactarius quieticolor</em>. Structural analysis revealed that HTP consists of a (1 → 6)-linked α-<span>d</span>-galactopyranose backbone, heavily substituted at <em>O</em>-2 by non-reducing rhamnose units, with a weight-average molar mass of 2.41 × 10<sup>4</sup> g.mol<sup>−1</sup>. <em>In vitro</em> assays using a triple-negative breast cancer (TNBC) cell model - the most aggressive subtype - showed a significant reduction in cell viability (50 % at 1200 μg·mL<sup>−1</sup>). Furthermore, an additive effect was observed when co-administered with the chemotherapy drug paclitaxel, reducing the cell viability to 42 %. These findings suggest potential therapeutic applications of the purified mushroom rhamnogalactan reported in this study against TNBC.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123735"},"PeriodicalIF":10.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yiting Fan , Jiahao Ren , Xinglong Xiao , Yifang Cao , Youning Zou , Bowen Qi , Xuying Luo , Fengsong Liu
{"title":"Recent advances in polysaccharide-based edible films/coatings for food preservation: fabrication, characterization, and applications in packaging","authors":"Yiting Fan , Jiahao Ren , Xinglong Xiao , Yifang Cao , Youning Zou , Bowen Qi , Xuying Luo , Fengsong Liu","doi":"10.1016/j.carbpol.2025.123779","DOIUrl":"10.1016/j.carbpol.2025.123779","url":null,"abstract":"<div><div>Fruits and vegetables are highly susceptible to spoilage and deterioration after harvest due to ongoing metabolic activities and, most critically, microbial contamination, resulting in substantial losses and waste. To address the increasing consumer demand for safe, eco-friendly, nutritious, and long-shelf-life foods, polysaccharide-based edible films and coatings have emerged as an innovative and sustainable solution for food packaging. This paper presents a comprehensive review of the preparation and manufacturing methods of polysaccharide-based edible films and coatings, highlighting their key characteristics and applications. It systematically examines their classification, recent advancements, and impacts on food quality. Particular attention is given to recent innovations in active packaging, modified packaging, and intelligent packaging technologies. The review also explores the limitations of polysaccharide-based edible films and coatings in the post-harvest preservation of fruits and vegetables, discusses the latest developments in this field, and outlines promising future research directions. By synthesizing these insights, this paper aims to assist researchers in the food and related industries, offering valuable perspectives on the development trends of polysaccharide-based edible film and coating technology for sustainable food packaging.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123779"},"PeriodicalIF":10.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Usman Rasheed , Bin Liu , Qurat Ul Ain , Ganhui Mo , Bin Shan , Kaikai Meng , Ganlin Chen
{"title":"Enhanced antifungal activity of chitosan-coated cinnamaldehyde-immobilized thermostable cellulose from spent mushroom substrate against phytopathogenic fungi","authors":"Usman Rasheed , Bin Liu , Qurat Ul Ain , Ganhui Mo , Bin Shan , Kaikai Meng , Ganlin Chen","doi":"10.1016/j.carbpol.2025.123790","DOIUrl":"10.1016/j.carbpol.2025.123790","url":null,"abstract":"<div><div>Phytopathogenic fungi jeopardize global food security, fueling reliance on synthetic fungicides with severe ecological impacts. Avoiding these chemicals risks a food crisis, highlighting the need for sustainable alternatives. Cinnamaldehyde (CA) is a natural but chemically unstable fungicide, hence requiring stabilization through effective immobilization. This study presents a biodegradable and sustainable alternative to synthetic anchoring materials: spent-mushroom-substrate-derived cellulose. CA immobilized cellulose was coated with chitosan which further enhanced the antifungal potential and contributed to slow release of CA. Cellulose extraction and CA encapsulation were successfully confirmed through analytical characterization. The resulting product (CeCACs) proved a promising fungicide, inhibiting key phytopathogenic fungi <em>Fusarium oxysporum</em>, <em>Aspergillus flavus</em>, and <em>Aspergillus niger</em> at 46. 8 μg/mL and <em>Fusarium solani</em> at 93.7 μg/mL concentration. The obtained minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values were significantly lower than commercial fungicide, tebuconazole (TB). The fungicidal mechanism involved reactive oxygen species accumulation, plasma membrane damage, and apoptosis-like cell death. Using CeCACs as a peanut seed coating enhanced seedling growth and enriched beneficial endophytic bacteria, while CeCACs fumigation effectively eradicated <em>Fusarium oxysporum</em> from peanut and passion fruit surfaces. This study emphasizes converting agri-waste into a green fungicide, supporting sustainable and regenerative agriculture.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123790"},"PeriodicalIF":10.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical-type dextran: A review on process and enzyme engineering strategies to control molecular weight distribution","authors":"Pia Lanvers, Jannis Broeker, Jochen Schmid","doi":"10.1016/j.carbpol.2025.123783","DOIUrl":"10.1016/j.carbpol.2025.123783","url":null,"abstract":"<div><div>Dextrans are α-(1 → 6)-linked, mostly branched α-<span>d</span>-glucopyranosyl polysaccharides synthesized from sucrose by lactic acid bacteria. The unique properties of dextrans, their biocompatibility, biodegradability, and non-immunogenicity support a wide range of medical and industrial applications. Key characteristics of dextran, including solubility, viscosity, and molecular weight, highly depend on the bacterial strain and the conditions under which it is synthesized. The structural diversity within the family of dextran-synthesizing enzymes contributes to dextran diversity. Conventionally, dextran with low molecular weight is obtained by fermentative production of high molecular weight dextran, followed by partial hydrolysis and a precise fractionation procedure, which is a costly and hazardous process. However, recent advances in enzyme- and bioprocess engineering in combination with analytical techniques have significantly enhanced the ability to control the molecular weight and branching patterns of dextran. Thereby improving its effectiveness and broadening its applications in both industrial and clinical settings. This review focuses on the production of dextrans with defined molecular weight and the enzymatic mechanisms underlying their synthesis, which have been increasingly studied in recent years. In particular, clinical-type dextran with a molecular weight of 70 kDa is of high commercial value and scientific interest.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123783"},"PeriodicalIF":10.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144170776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bin Wang , Xuezhou Wang , Hongxia Ma , Jinpeng Li , Daxian Cao , Jun Xu , Jinsong Zeng , Wenhua Gao , Kefu Chen
{"title":"Enhancing the mechanical and barrier properties of starch-based green packaging films via acetalization reaction and hydrogen bond dual crosslinking","authors":"Bin Wang , Xuezhou Wang , Hongxia Ma , Jinpeng Li , Daxian Cao , Jun Xu , Jinsong Zeng , Wenhua Gao , Kefu Chen","doi":"10.1016/j.carbpol.2025.123787","DOIUrl":"10.1016/j.carbpol.2025.123787","url":null,"abstract":"<div><div>As an abundant, eco-friendly bio-material, starch has great potential to address pollution from petroleum-based plastic films, but starch-based films still need improved mechanical and barrier properties for practical use. Therefore, this study proposes an oxidation-dual crosslinking strategy. Native cassava starch (CS) was initially oxidized using NaIO4 to produce dialdehyde starch (DAS). Subsequently, polyvinyl alcohol (PVA) and cellulose nanofibrils (CNF) were incorporated into the DAS matrix, forming a compact-structured DAS composite film, through a dual crosslinking network involving acetalization reactions and intermolecular hydrogen bonding. Compared with the CS film, the optimized DAS-6c-12p composite film (with 6 % CNF and 12 % PVA based on the dry weight of DAS) demonstrated significant improvements in mechanical and barrier properties: tensile strength increased from 15.28 ± 1.11 MPa to 65.67 ± 2.50 MPa, tensile strain rose from 4.67 ± 0.68 % to 6.21 ± 0.13 %, water vapor permeability coefficient decreased from 11.50 ± 0.60 to 3.04 ± 0.19 g·mm/(m<sup>2</sup>·d), oxygen permeability coefficient reduced from 10.322 ± 0.303 to 0.097 ± 0.003 cm<sup>3</sup>·mm/(m<sup>2</sup>·d·0.1 MPa), and edible oil permeability coefficient declined from 4.80 ± 0.14 to 0.50 ± 0.02 g·mm/(m<sup>2</sup>·d). Notably, compared to the polyethylene packaging film, this composite film exhibited superior fruit preservation capability and biodegradability. This work provides a novel strategy for developing biobased high strength barrier film.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123787"},"PeriodicalIF":10.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liran Ji , Jiaxiang Du , Wei Zhang , Zeping Lu , Binbin Nian , Yi Hu
{"title":"Dual role of ionic liquid modified β-Cyclodextrin in dynamic conformational regulation and substrate enrichment for improved lipase immobilization","authors":"Liran Ji , Jiaxiang Du , Wei Zhang , Zeping Lu , Binbin Nian , Yi Hu","doi":"10.1016/j.carbpol.2025.123786","DOIUrl":"10.1016/j.carbpol.2025.123786","url":null,"abstract":"<div><div>To address the limitations of free enzymes in industrial applications, immobilization technologies have garnered significant attention as a robust strategy for enhancing operational stability and reusability. In this work, a novel-designed immobilized lipase (Fe<sub>3</sub>O<sub>4</sub>@β-CD-IL-CRL) was successfully developed via the introduction of β-cyclodextrin (β-CD), Fe<sub>3</sub>O<sub>4</sub> nanoparticles and ionic liquid (IL). The properties studies indicated that Fe<sub>3</sub>O<sub>4</sub>@β-CD-IL-CRL exhibited remarkable stability, maintaining 72.8 % residual activity after 7 successive catalytic cycles and retaining more than 80 % of its initial activity following 2 h incubation at 60 °C. Furthermore, to examine the practical applications of Fe<sub>3</sub>O<sub>4</sub>@β-CD-IL-CRL, it was used in the synthesis of phytosterol esters. The results suggested that a yield of 95.0 % can be obtained at 50 °C in 48 h, highlighting its exceptional catalytic efficiency. Molecular dynamics (MD) simulations showed that the immobilization of Fe<sub>3</sub>O<sub>4</sub>@β-CD-IL maintained an optimal pocket size for CRL, which was advantageous for substrate anchoring. Additionally, analyses of the lid structure distance and tunnel further supported this finding. Beyond the impact on the dynamic conformation of lipase, β-CD was also found to effectively enrich substrates, enhancing catalytic efficiency. This discovery offers new insights into the optimization of biocatalytic systems and highlights the potential of β-CD as a versatile carrier for enzyme immobilization.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123786"},"PeriodicalIF":10.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nouaamane El Idrissi , Hicham Aitbella , Nicolas Merle , Frédéric Cazaux , João P. Prates Ramalho , Larbi Belachemi , Hamid Kaddami , Philippe Zinck
{"title":"Cellulose nanocrystals-supported organocatalyst for the synthesis of cyclic carbonates via cycloaddition of carbon dioxide to epoxide","authors":"Nouaamane El Idrissi , Hicham Aitbella , Nicolas Merle , Frédéric Cazaux , João P. Prates Ramalho , Larbi Belachemi , Hamid Kaddami , Philippe Zinck","doi":"10.1016/j.carbpol.2025.123762","DOIUrl":"10.1016/j.carbpol.2025.123762","url":null,"abstract":"<div><div>The synthesis of cyclic carbonates can be realized via cycloaddition of CO<sub>2</sub> to epoxides. Organocatalysts are of interest regarding specific applications. The reaction can be co-activated by a hydrogen bond donor such as cellulose. A fully recyclable catalytic system combining an organocatalyst and a polysaccharide hydrogen bond donor has never been reported. In this study, we have supported an organocatalyst onto cellulose nanocrystals (CNC). The grafting of 1,5,7-triazabicyclo [4.4.0] dec-5-ene (TBD) onto microcrystalline cellulose (MCC) and onto the surface of cellulose nanocrystals (CNC) was confirmed by <sup>13</sup>C solid state NMR, FT-IR, XRD and elemental analysis. The prepared heterogeneous TBD-CNC nanocatalyst was successfully assessed on a scope of five epoxides including mono- and di-substituted. The activity was found to be higher than that of the TBD-MCC supported catalyst, and higher than the homogeneous counterpart. That latter result highlights the coactivation role of the polysaccharide. Recyclability studies showed that the catalyst is reusable for at least five cycles. Density functional theory (DFT) studies indicate that the mechanism most probably involves the formation of anionic cellulosic species. Initially, the grafted TBD deprotonates a surface hydroxy to form a cellulose alkoxide, which then performs a nucleophilic attack on CO<sub>2</sub> or on the activated epoxide.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123762"},"PeriodicalIF":10.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liping Yin , Zhe Cui , Jintao Ma , Weichen Sun , Yu Zhang , Yong Wang , Wenjuan Li , Xianling Wang , Jianglei Qin
{"title":"Mussel inspired carboxymethyl cellulose/pectin composite hydrogel with photothermal enhanced antibacterial property for burn wound healing","authors":"Liping Yin , Zhe Cui , Jintao Ma , Weichen Sun , Yu Zhang , Yong Wang , Wenjuan Li , Xianling Wang , Jianglei Qin","doi":"10.1016/j.carbpol.2025.123780","DOIUrl":"10.1016/j.carbpol.2025.123780","url":null,"abstract":"<div><div>The burn wounds are particularly susceptible to bacterial infection, while the hydrogel wound dressings with antibacterial property are expected to promote burn wound repairing progress. In this research, carboxymethyl cellulose bearing hydrazide groups and hemostatic polyphosphate moiety (CHP) was synthesized and cross-linked with dopamine grafted oxidized pectin (OPD) to prepare hemostatic self-healing hydrogel for burn wound repairing. Polydopamine coated graphene oxide (PGO) was loaded into the hydrogel to endow it with photothermal stimulated antibacterial property and enhanced the ROS scavenging ability, which can inhibit bacterial infection and promote tissue regeneration. Moreover, the loaded tannic acid (TA) further enhanced the antioxidant and anti-inflammatory properties of the hydrogel. As a result, the photothermal property of PGO and TA greatly reduced bacterial infection and promoted cell proliferation both <em>in vitro</em> and <em>in vivo</em>. More importantly, the composite PGO/TA/Gel hydrogel exhibited satisfactory therapeutic effect in burn wound healing in mice model through reducing inflammation response, enhance the collagen deposition and promote angiogenesis based on histological analysis. These advantages make this composite hydrogel great potential applications in the field of wound dressings in biomedication.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123780"},"PeriodicalIF":10.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Trejo-Cáceres, J.E. Martín-Alfonso, J.M. Franco
{"title":"Silylation of wheat straw cellulose pulp for its valorization as rheology modifier of industrial hydrophobic fluids: Cases of castor oil and bitumen","authors":"M. Trejo-Cáceres, J.E. Martín-Alfonso, J.M. Franco","doi":"10.1016/j.carbpol.2025.123778","DOIUrl":"10.1016/j.carbpol.2025.123778","url":null,"abstract":"<div><div>This work explores an innovative approach to developing novel oleo- and bitumen-based dispersions, which are potentially applicable as semisolid lubricants and bitumen binders, respectively, using lignocellulosic biomass. In particular, it focuses on investigating the impact of the silylation process of wheat straw Kraft cellulose pulp (KWP) on the rheological properties of these dispersions. To this end, KWP was functionalized with <em>tert</em>-butyldimethylsilyl chloride (TBDMSCl), using imidazole (ImH) as a catalyst, through a simple and efficient method. Different conditions of the silylation process such as temperature (20–100 °C), TBDMSCl/ImH ratio (1/2.5–2.5/2.5), and silylation time (2–24 h) were applied to illustrate the flexibility of the proposed methodology. Modified pulps with oil and/or bitumen structuring ability were obtained, as a result of the interaction between the hydrophobic alkyl-siloxane segment-containing fibers and these hydrophobic fluids, which enhance the compatibility between both components. Oleo-dispersions with a similar viscoelastic response to lithium grease, used as a benchmark, exhibited significantly reduced coefficients of friction and wear. Meanwhile, bitumen-dispersions displayed a substantial improvement in stiffness and elasticity with the temperature. This work may offer a novel strategy for developing rheology modifiers or structuring agents for industrial hydrophobic fluids.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123778"},"PeriodicalIF":10.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mengyao Yuan , Lijia Liu , Xiaoqing Ma , Lihua Geng , Xiuliang Wang , Ning Wu , Yang Yue , Quanbin Zhang , Jing Wang
{"title":"Comprehensive analysis of salicylic acid-derivatized alginate: Synthesis, characterization, and anti-acne potential","authors":"Mengyao Yuan , Lijia Liu , Xiaoqing Ma , Lihua Geng , Xiuliang Wang , Ning Wu , Yang Yue , Quanbin Zhang , Jing Wang","doi":"10.1016/j.carbpol.2025.123776","DOIUrl":"10.1016/j.carbpol.2025.123776","url":null,"abstract":"<div><div>Salicylic acid (SA) is commonly utilized in the early treatment of acne due to its therapeutic efficacy. However, its clinical performance is hindered by limited aqueous solubility, stability and potential for irritation. This study addresses these challenges through deriving SA with alginate (SA-g-Alg) based on a complementary advantages strategy, designed to retain the bioactivity of SA while mitigating its drawbacks. A comprehensive investigation into the structure, physiochemical properties and anti-acne bioactivities of SA-g-Alg was conducted. The results demonstrate that SA-g-Alg achieved a 30-fold higher aqueous stability compared to free SA, along with enhanced moisturizing capacity and reduced cytotoxicity and skin irritation. These enhancements were attributed to the multi-hydroxy and inherent high biocompatibility of alginate. It is noteworthy that SA-g-Alg, with a grafting degree of 24.9 %, exhibited a synergistic effect, as evidenced by its superior lipid regulating ability, comparable antibacterial efficacy and prolonged anti-inflammatory bioavtivity compared to equivalent salicylic acid group in free SA. Moreover, <em>in vivo</em> studies employing a rabbit ear acne model show that a 2 % SA-g-Alg formulation was as effective as a clinical established 2 % SA ointment in therapeutic management of acne. In conclusion, this study underscores the enhanced physiochemical and anti-acne properties of SA-g-Alg, highlighting its potential as a promising therapeutic agent for the treatment of mild to moderate acne.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"364 ","pages":"Article 123776"},"PeriodicalIF":10.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}