Carbohydrate Polymers最新文献_第3页

Studying relaxation phenomena in fruit and vegetable pectin-containing cell wall material: a focus on methodology and composition. 果蔬含果胶细胞壁材料弛豫现象的研究：方法和组成的重点。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-15 Epub Date: 2025-07-29 DOI: 10.1016/j.carbpol.2025.124137

J Van Audenhove, C N Ngong, A M Van Loey, M E Hendrickx

{"title":"Studying relaxation phenomena in fruit and vegetable pectin-containing cell wall material: a focus on methodology and composition.","authors":"J Van Audenhove, C N Ngong, A M Van Loey, M E Hendrickx","doi":"10.1016/j.carbpol.2025.124137","DOIUrl":"10.1016/j.carbpol.2025.124137","url":null,"abstract":"This study characterizes the relaxation phenomena, particularly the α-relaxation, in the semi-dry alcohol-insoluble residue (AIR) of apple, carrot, and tomato across a relevant moisture content (MC) range. It examines changes in thermal properties via differential scanning calorimetry (DSC), compressibility through thermal mechanical compression testing (TMCT), and viscoelastic properties using dynamic mechanical thermal analysis. Chemical characterization was conducted to link relaxation behavior to polymer composition. DSC showed minimal changes at the relaxation temperature (Tr), but significant differences in relaxation behavior, represented by the Tr-line, among botanical origins were observed. A higher ratio of amorphous polysaccharides to crystalline cellulose and greater pectin branching correlated with lower Tr-values. Mechanical techniques provided clearer signals than DSC due to their direct link to molecular mobility changes with increasing MC or temperature. Except for the carrot AIR Tr-line obtained by TMCT, the AIR Tr-lines were not significantly different among the matrices when assessed by mechanical techniques. This study highlights fundamental aspects and challenges in determining relaxation phenomena in AIR and identifies general trends related to composition. The methods and insights can be used in future studies on the role of cell wall material composition in relaxation phenomena and in predicting associated physical collapse phenomena.","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"368 Pt 2","pages":"124137"},"PeriodicalIF":12.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ideal dietary fiber model: Personalized gut microbiota modulation based on structure-function relationships. 理想膳食纤维模型：基于结构-功能关系的个性化肠道菌群调节。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-15 Epub Date: 2025-07-24 DOI: 10.1016/j.carbpol.2025.124097

Chengming Wang, Shining Qin, Jiaqi Shi, Junrui Zhu, Xiaoxue Ju, Wenjing Wang, Lijie Yang

{"title":"Ideal dietary fiber model: Personalized gut microbiota modulation based on structure-function relationships.","authors":"Chengming Wang, Shining Qin, Jiaqi Shi, Junrui Zhu, Xiaoxue Ju, Wenjing Wang, Lijie Yang","doi":"10.1016/j.carbpol.2025.124097","DOIUrl":"10.1016/j.carbpol.2025.124097","url":null,"abstract":"Dietary fiber has emerged as a central modulator of gut microbiota composition and host physiology, garnering unprecedented scientific attention. Here, we propose the \"Ideal Dietary Fiber Model\"-a personalized, structure-guided framework designed to precisely shape gut microbial ecosystems and promote host health. Departing from traditional fiber classifications, this model emphasizes the construction of composite fiber formulations based on detailed structural parameters, including monosaccharide composition, glycosidic linkage types, and degree of polymerization. Particular focus is given to oligosaccharides, whose fine structural features confer high selectivity in modulating microbial communities and the production of key metabolites such as short-chain fatty acids, indoles, and neurotransmitter precursors. This review synthesizes recent advances in fiber-microbiota interactions across metabolic, inflammatory, and neurocognitive diseases, including obesity, type 2 diabetes, Non-Alcoholic Fatty Liver Disease, inflammatory bowel disease, colorectal cancer, depression, anxiety, and Alzheimer's disease. While mechanistic insights continue to expand, current evidence remains largely preclinical, highlighting the gap between experimental findings and clinical translation. We argue that integrating microbiome stratification with fiber structure-function databases will be essential for advancing precision nutrition. The Ideal Dietary Fiber Model offers a conceptual and practical foundation for microbiota-targeted dietary design, but its therapeutic potential requires rigorous clinical validation.","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"368 Pt 2","pages":"124097"},"PeriodicalIF":12.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Concern: "Tunable drug release from nanofibers coated with blank cellulose acetate layers fabricated using tri-axial electrospinning" [Carbohydrate Polymers 203 (2019) 228-237]. 关注表达：“利用三轴静电纺丝制备的空白醋酸纤维素层涂层纳米纤维的可调节药物释放”[碳水化合物聚合物203(2019)228-237]。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-15 Epub Date: 2025-07-03 DOI: 10.1016/j.carbpol.2025.124011

引用次数: 0

A fungal polysaccharide from Trametes orientalis: Structural elucidation and multifaceted antitumor mechanisms via metastasis, angiogenesis, and immunomodulation. 一种真菌多糖：结构解析和通过转移、血管生成和免疫调节的多方面抗肿瘤机制。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-15 Epub Date: 2025-07-29 DOI: 10.1016/j.carbpol.2025.124151

Wenrui He, Haojing Jiang, Mingming Rong, Xinxing Li, Jing Xu, Yuanqiang Guo

{"title":"A fungal polysaccharide from Trametes orientalis: Structural elucidation and multifaceted antitumor mechanisms via metastasis, angiogenesis, and immunomodulation.","authors":"Wenrui He, Haojing Jiang, Mingming Rong, Xinxing Li, Jing Xu, Yuanqiang Guo","doi":"10.1016/j.carbpol.2025.124151","DOIUrl":"10.1016/j.carbpol.2025.124151","url":null,"abstract":"Cancer remains a formidable global health challenge, underscoring the critical need for innovative and highly effective therapeutic agents. Fungal polysaccharides have gained increasing attention in anti-cancer drug development due to their remarkable structural diversity and biological activities. This study reports the isolation and comprehensive characterization of TOP60-1, a novel homogeneous polysaccharide with a molecular weight of 1.122 × 104 g/mol, meticulously purified from the fruiting bodies of Trametes orientalis (Yasuda) Imaz. Structural analysis revealed TOP60-1 to be a complex heteropolysaccharide comprising various glycosidic linkages, including →4)-β-d-Glcp-(1→, →3)-β-d-Glcp-(1→, →6)-β-d-Glcp-(1→, →3,6)-β-d-Glcp-(1→, β-d-Glcp-(1→, →2,6)-α-d-Galp-(1→, →6)-α-d-Galp-(1→, →4,6)-α-d-Manp-(1→, α-l-Fucp-(1→, 3-OMe-α-l-Fucp-(1 → and →3)-α-l-Fucp-(1→. Biological evaluations demonstrated that TOP60-1 dose-dependently suppressed tumor growth, metastasis, and angiogenesis in a zebrafish xenograft model, induced tumor cell apoptosis, and significantly inhibited tumor cell migration in vitro. Furthermore, immunomodulatory investigations elucidated that TOP60-1 directly interacts with macrophage surface receptors TLR-2 and TLR-4, effectively promoting macrophage M1 polarization and upregulating the expression of critical M1-associated surface markers (CD40, CD80, CD86, MHC-II). Collectively, these findings unequivocally demonstrate that TOP60-1 possesses potent antitumor activity mediated by direct effects synergistic with profound indirect immunomodulatory mechanisms. This highlights its substantial therapeutic potential as a promising novel candidate for tumor immunotherapy.","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"368 Pt 2","pages":"124151"},"PeriodicalIF":12.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bayesian-assisted mechanochemical synthesis of carboxylated cellulose nanocrystals and its application in Pickering emulsion. 贝叶斯辅助下羧化纤维素纳米晶的机械化学合成及其在皮克林乳液中的应用。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-15 Epub Date: 2025-08-06 DOI: 10.1016/j.carbpol.2025.124183

Xinyu Lin, Weike Su, Qihong Zhang

{"title":"Bayesian-assisted mechanochemical synthesis of carboxylated cellulose nanocrystals and its application in Pickering emulsion.","authors":"Xinyu Lin, Weike Su, Qihong Zhang","doi":"10.1016/j.carbpol.2025.124183","DOIUrl":"https://doi.org/10.1016/j.carbpol.2025.124183","url":null,"abstract":"The preparation of carboxylated cellulose nanocrystals (CNCs) by ammonium persulfate (APS) oxidation is a relatively common method, but the low reaction efficiency limits its application. In this study, carboxylated CNCs (CNCs-COOH) were efficiently synthesized by mechanochemistry and assisted by the Bayesian Optimization Algorithm (BOA). Under the optimal conditions: reaction temperature of 60 °C, oscillation frequency of 30 Hz, reaction time of 25 min, ball-to-material ratio of 31.8, liquid addition amount of 2 μL/mg, and APS concentration of 0.5 M, the maximum CNCs-COOH yield of 90.45 % was achieved. CNCs-COOH had crystallinity of 78.26 % and particle size of 196.15 ± 18.23 nm, which has better physicochemical property than the carboxylated CNCs (AOCNC) prepared by the conventional solution method. Furthermore, CNCs-COOH was used as suspension stabilizer for the preparation of oil-in-water vitamin A acetate Pickering emulsion, which showed excellent physical and thermal stability. Therefore, mechanochemical APS oxidation is a green and economical alternative to prepare CNCs-COOH, which has prospect in application as suspension stabilizer.","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"368 Pt 2","pages":"124183"},"PeriodicalIF":12.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145062998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional nanocomposite chitosan-based hydrogel promotes healing of infected wounds through sustained release of Zn²⁺ and nicotinamide mononucleotide. 多功能纳米复合壳聚糖基水凝胶通过持续释放Zn2+和烟酰胺单核苷酸促进感染伤口愈合。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-15 Epub Date: 2025-07-24 DOI: 10.1016/j.carbpol.2025.124111

Hao Zhang, Hang Wu, Lei Zhang

{"title":"Multifunctional nanocomposite chitosan-based hydrogel promotes healing of infected wounds through sustained release of Zn2+ and nicotinamide mononucleotide.","authors":"Hao Zhang, Hang Wu, Lei Zhang","doi":"10.1016/j.carbpol.2025.124111","DOIUrl":"10.1016/j.carbpol.2025.124111","url":null,"abstract":"Compromised cellular function and bacterial infection are major obstacles to effective wound healing. Simultaneous bacterial elimination and cellular function restoration represent a promising strategy for treating infected wounds. Here, a multifunctional hydrogel (QMPZN) composed of methacrylate anhydride (MA)-grafted quaternary ammonium chitosan (QCS-MA), polyvinyl alcohol (PVA), zeolitic imidazolate framework-8 (ZIF-8), and nicotinamide mononucleotide (NMN, a precursor of NAD+ involved in cellular metabolism and repair) was developed to achieve combined antibacterial and regenerative effects. The hydrogel rapidly forms in situ under UV light via methacrylate double bond cross-linking, enabling application to irregular wound surfaces. PVA enhances its mechanical strength and tissue adhesion through hydrogen bonding. Benefiting from quaternary ammonium groups and the sustained Zn2+ release from ZIF-8, QMPZN exhibits strong and durable antibacterial activity. Meanwhile, the controlled release of NMN helps restore cellular function and promote tissue regeneration. In vivo studies showed that QMPZN effectively inhibited bacterial infection and accelerated epithelial regeneration and collagen deposition in infected wounds. These results suggest that QMPZN hydrogel is expected to be a therapeutic platform for the treatment of infected wounds.","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"368 Pt 2","pages":"124111"},"PeriodicalIF":12.5,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Multichannel nerve conduit based on chitosan derivates for peripheral nerve regeneration and Schwann cell survival" [Carbohydrate Polymers 301 (2023) 120327]. “基于壳聚糖衍生物的多通道神经导管用于周围神经再生和雪旺细胞存活”[碳水化合物聚合物301(2023)120327]的更正。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-01 Epub Date: 2025-07-29 DOI: 10.1016/j.carbpol.2025.123952

Zhiwen Jiang, Yijie Zhang, Yanting Wang, Shuo Wang, Jing Chang, Wanshun Liu, Baoqin Han

引用次数: 0

Corrigendum to "A versatile chitosan nanogel capable of generating AgNPs in-situ and long-acting slow-release of Ag⁺ for highly efficient antibacterial" [Carbohydr. Polym., 2021, 257, 117636]. “一种多功能壳聚糖纳米凝胶，能够原位生成AgNPs，长效缓释Ag+，用于高效抗菌”[碳水化合物]的勘误表。变异较大。[j].农业科学，2017,27(2):117636。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-01 Epub Date: 2025-07-25 DOI: 10.1016/j.carbpol.2025.123950

Mengni Fan, Jingxing Si, Xiaogang Xu, Linfu Chen, Junpeng Chen, Chao Yang, Jingwu Zhu, Lihuang Wu, Jiang Tian, Xiaoyi Chen, Xiaozhou Mou, Xiaojun Cai

引用次数: 0

Corrigendum to "Fabrication of Cu²⁺-loaded phase-transited lysozyme nanofilm on bacterial cellulose: Antibacterial, anti-inflammatory, and pro-angiogenesis for bacteria-infected wound healing" [Carbohydrate Polymers 309 (2023) 120681]. “在细菌纤维素上制备Cu2+负载的相转移溶菌酶纳米膜：细菌感染伤口愈合的抗菌、抗炎和促血管生成”[碳水化合物聚合物309(2023)120681]的更正。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-01 Epub Date: 2025-07-28 DOI: 10.1016/j.carbpol.2025.123951

Wei He, Xiaodong Wang, Tian Hang, Jing Chen, Zhichao Wang, Dina A Mosselhy, Jin Xu, Shitao Wang, Yudong Zheng

引用次数: 0

Corrigendum to "Chitosan-poly(lactide-CO-glycolide)/poloxamer mixed micelles as a mucoadhesive thermo-responsive moxifloxacin eye drop to improve treatment efficacy in bacterial keratitis" [Carbohydrate Polymers 312 (2023) 120822]. “壳聚糖-聚（丙交酯- co -乙醇酸）/波洛沙姆混合胶束作为黏附热响应性莫西沙星滴眼液提高细菌性角膜炎治疗疗效”的更正[碳水化合物聚合物312(2023)120822]。

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2025-11-01 Epub Date: 2025-07-29 DOI: 10.1016/j.carbpol.2025.123953

Sanjay Ch, Sri Ganga Padaga, Balaram Ghosh, Sanhita Roy, Swati Biswas

引用次数: 0