Carbohydrate Polymers最新文献_第4页

Sulphated zirconia on cyclodextrin nanosponge: A carbohydrate-based catalyst for conversion of mono-saccharides to 5-hydroxymethylfurfural 环糊精纳米海绵上的硫化氧化锆：将单糖转化为 5-羟甲基糠醛的碳水化合物基催化剂

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-21 DOI: 10.1016/j.carbpol.2024.123053

Sohaila Yaghoubi , Azita Jahanian , Samahe Sadjadi

{"title":"Sulphated zirconia on cyclodextrin nanosponge: A carbohydrate-based catalyst for conversion of mono-saccharides to 5-hydroxymethylfurfural","authors":"Sohaila Yaghoubi , Azita Jahanian , Samahe Sadjadi","doi":"10.1016/j.carbpol.2024.123053","DOIUrl":"10.1016/j.carbpol.2024.123053","url":null,"abstract":"<div><div>To expand the utility of cyclodextrin nanosponges for catalytic purpose, β-cyclodextrin nanosponge was prepared via melting method and then utilized as a catalyst support for the stabilization of sulphated zirconia<sub>.</sub> The resulting catalyst, denoted as CDNS-SO<sub>4</sub><sup>2−</sup>/ZrO<sub>2</sub>, was then applied as a heterogeneous acidic catalyst for conversion of fructose to 5-hydroxymethylfurfural. The results, underpinned that the catalytic activity of CDNS-SO<sub>4</sub><sup>2−</sup>/ZrO<sub>2</sub>, was superior to that of ZrO<sub>2</sub> and SO<sub>4</sub><sup>2−</sup>/ZrO<sub>2</sub>, confirming the role of sulfonation of ZrO<sub>2</sub> and immobilization of SO<sub>4</sub><sup>2−</sup>/ZrO<sub>2</sub> on CDNS in catalysis. To optimize the reaction parameters and achieve maximum yield of the desired product, Response Surface Method that is an accurate procedure for appraising the impacts of the reaction variables was employed and it was found that using 35 wt% CDNS-SO<sub>4</sub><sup>2−</sup>/ZrO<sub>2</sub> at 80 °C, HMF in 93 % yield was achieved in 45 min. Kinetic study also showed that the activation energy was 13.28 kJ/mol. Furthermore, thermodynamic parameters, i.e. enthalpy, entropy and Gibbs free energy were estimated as 10.46 kJ/mol, −150.40 J/mol and 63.58 kJ/mol respectively. Noteworthy, the catalysis was true heterogeneous, as confirmed by Hot filtration test and the catalyst could be recycled several times with low leaching of SO<sub>4</sub><sup>2−</sup>/ZrO<sub>2</sub>.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 123053"},"PeriodicalIF":10.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methyl-esterification, degree of polymerization and ∆4,5-unsaturation of galacturonic acid oligosaccharides as determinants of immunomodulation 半乳糖醛酸寡糖的甲基酯化、聚合度和∆4,5-不饱和度是免疫调节的决定因素

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-21 DOI: 10.1016/j.carbpol.2024.123052

J.W. Zwolschen , M.M.M. Tomassen , A.P. Vos , H.A. Schols

{"title":"Methyl-esterification, degree of polymerization and ∆4,5-unsaturation of galacturonic acid oligosaccharides as determinants of immunomodulation","authors":"J.W. Zwolschen , M.M.M. Tomassen , A.P. Vos , H.A. Schols","doi":"10.1016/j.carbpol.2024.123052","DOIUrl":"10.1016/j.carbpol.2024.123052","url":null,"abstract":"<div><div>In recent years, immunomodulation by pectin and pectin-derived galacturonic acid oligosaccharides has been the subject of wide-spread scientific research due to the potential of different pectin structures as bioactive biomolecules. Yet, gaps remain in understanding the structure-dependent immunomodulation of galacturonic acid. This study describes <em>in vitro</em> immunomodulatory effects of well-characterized galacturonic acid oligosaccharides. Both methyl-esterified and non-methyl-esterified galacturonic acid oligosaccharides with a saturated non-reducing end (degree of polymerization 1–10) significantly induced cytokine production by THP-1 macrophages and directly activated TLR2 and TLR4 in transfected HEK-293 cells, even when accounting for minor endotoxin contamination. In contrast, both methyl-esterified and non-methyl-esterified galacturonic acid oligosaccharides with a Δ4,5-unsaturated non-reducing end (degree of polymerization 1–7) did not activate TLR2 and TLR4 and led to significantly reduced cytokine production (<em>p</em> < 0.05), suggesting Δ4,5-(un)saturation as a pivotal factor for immunomodulation by galacturonic acid oligosaccharides. Exposure to non-methyl-esterified saturated galacturonic acid oligosaccharides resulted in significantly lower TNF-α production, IL-1β production and TLR4 activation (<em>p</em> < 0.05) compared to methyl-esterified saturated galacturonic acid oligosaccharides, while IL-10 production and TLR2 activation remained unchanged. These findings establish galacturonic acid oligosaccharides as versatile immunomodulators with TLR2 and TLR4 binding capacity, fit for different immunomodulatory applications depending on their structural characteristics.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 123052"},"PeriodicalIF":10.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosslinked lignin starch copolymer as a sustainable and thermally stable drilling fluid controller

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-21 DOI: 10.1016/j.carbpol.2024.123044

Zahra Rashedi , Robert Mawhinney , Weijue Gao , Ayyoub Salaghi , Pedram Fatehi

{"title":"Crosslinked lignin starch copolymer as a sustainable and thermally stable drilling fluid controller","authors":"Zahra Rashedi , Robert Mawhinney , Weijue Gao , Ayyoub Salaghi , Pedram Fatehi","doi":"10.1016/j.carbpol.2024.123044","DOIUrl":"10.1016/j.carbpol.2024.123044","url":null,"abstract":"<div><div>Fluid loss is a well-known challenge of drilling operations. In this work, a novel sustainable starch-lignin-based polymer was synthesized for possible use in drilling fluid applications. The X-ray photoelectron spectroscopy (XPS) analysis confirmed that kraft lignin was crosslinked with starch via ether covalent bonds. The X-ray diffraction (XRD) analysis confirmed the loss of crystallinity in starch and emerging of new amorphous structures in crosslinked starch-lignin (CSL) polymers after crosslinking with lignin. The incorporation of lignin and new covalent ether bonds improved the thermal stability of starch. The CSL had a rougher surface morphology, higher hydrophilicity, and significantly higher water absorption than starch. CSL-2, with its higher lignin content, demonstrated higher hydrophilicity, better water absorption capacity, and thermal stability than CSL-1. The rheology analysis of the CSL-2 polymer suggested that crosslinking starch with lignin would increase G′ more than G\" and reduce tan δ of the polymer solution, resulting in more elastic properties and more stability against the angular frequency. Due to its improved swelling, thermal, and rheological properties as compared to native starch, the produced sustainable lignin-starch copolymer could be used as a new viscosity and rheology modifier, such as a fluid loss controller for oil extraction from wells.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 123044"},"PeriodicalIF":10.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the potential of chitosan in immunoassay sensor

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-20 DOI: 10.1016/j.carbpol.2024.123024

Zheng Jin , Guodong Huang , Yang Song , Xin Zheng , Kai Zhao

{"title":"Unlocking the potential of chitosan in immunoassay sensor","authors":"Zheng Jin , Guodong Huang , Yang Song , Xin Zheng , Kai Zhao","doi":"10.1016/j.carbpol.2024.123024","DOIUrl":"10.1016/j.carbpol.2024.123024","url":null,"abstract":"<div><div>Using new materials to improve detection accuracy and efficiency is important to broaden the application of immunoassay sensors. Among numerous materials for improving sensors, chitosan, as a natural polysaccharide, has excellent biocompatibility, mechanical adjustability, stimulation sensitivity and porous structure, which holds significant potential for enhancing the performance of immunoassay sensors. However, at present, there are few systematic reviews on the application of chitosan in immune sensors. In this paper, the principle of immunoassay is discussed systematically, we reviewed the recent development of chitosan enhancement strategies in various immunoassay sensors, including surface plasmon resonance immunoassay sensors, colorimetric immunoassay sensors, electrochemical immunoassay sensor, electrochemical luminescence immunoassay sensors are reviewed. Focused on the theoretical basis of improving sensor performance in immunoassay by use chitosan, as well as the various functions and applications of chitosan, and discussed how to solve the challenges of immunoassay sensors by using chitosan and the future research trend. By providing a robust foundation for the development of more efficient detection platforms, it provides insights for advancing the use of chitosan in the detection of complex biological samples. This is crucial for promoting the widespread application of immunoassay sensors with high performance in clinical diagnosis, environmental monitoring and food safety.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 123024"},"PeriodicalIF":10.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic acid-based hydrogels as codelivery systems: The effect of intermolecular interactions investigated by HR-MAS and solid-state NMR Spectroscopy 以透明质酸为基础的水凝胶作为代码传递系统：通过 HR-MAS 和固态 NMR 光谱研究分子间相互作用的影响

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-20 DOI: 10.1016/j.carbpol.2024.123043

Valeria Vanoli , Mosè Casalegno , Marina Carravetta , Fabio Pizzetti , Andrea Mele , Filippo Rossi , Franca Castiglione

{"title":"Hyaluronic acid-based hydrogels as codelivery systems: The effect of intermolecular interactions investigated by HR-MAS and solid-state NMR Spectroscopy","authors":"Valeria Vanoli , Mosè Casalegno , Marina Carravetta , Fabio Pizzetti , Andrea Mele , Filippo Rossi , Franca Castiglione","doi":"10.1016/j.carbpol.2024.123043","DOIUrl":"10.1016/j.carbpol.2024.123043","url":null,"abstract":"<div><div>Hydrogels based on hyaluronic acid and agarose-carbomer, due to their peculiar 3D architecture and biocompatibility, are promising candidates for pharmaceutical strategies based on the codelivery of drugs targeting different diseases. The successful development of these applications requires a precise understanding of drug-drug interactions and their effects on transport and release mechanisms. In this study, such an investigation is carried out on hydrogels loaded with ethosuximide and sodium salicylate at different concentrations. Intermolecular interactions and transport properties are characterized by means of High Resolution Magic Angle Spinning and solid-state Magic Angle Spinning NMR Spectroscopy.</div><div>At variance with our previous findings on single-drug formulations, the two drugs exhibit closely similar diffusion patterns when co-loaded in the HA-based hydrogels, plausibly due to drug-drug intermolecular interactions. At the highest drug concentrations, where superdiffusion comes into play, we find a fraction of molecules with time-varying diffusion coefficients. A trapping-release mechanism is proposed to explain this observation, which also accounts for the role of drug-hydrogel interactions in drug diffusion motion. The effects of drug-drug interactions on release profiles are finally assessed by means of in vitro release experiments.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 123043"},"PeriodicalIF":10.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan and gelatin based sprayable hydrogels incorporating photothermal and long-acting antibiotic sterilization for infected wound management with shape adaptability 基于壳聚糖和明胶的可喷涂水凝胶，结合了光热和长效抗生素杀菌技术，可用于感染性伤口管理，并具有形状适应性

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-20 DOI: 10.1016/j.carbpol.2024.123046

Fei Wang , Xing Wang , Siwei Li , Qisen Yang , Haibo Mu , Jinyao Li , Yu Yang

{"title":"Chitosan and gelatin based sprayable hydrogels incorporating photothermal and long-acting antibiotic sterilization for infected wound management with shape adaptability","authors":"Fei Wang , Xing Wang , Siwei Li , Qisen Yang , Haibo Mu , Jinyao Li , Yu Yang","doi":"10.1016/j.carbpol.2024.123046","DOIUrl":"10.1016/j.carbpol.2024.123046","url":null,"abstract":"<div><div>Severe skin damage resulting from acute trauma is often accompanied by uncontrolled bleeding, microbial infections, and delayed wound healing. Herein, multifunctional sprayable hydrogels (CT-CS-ZIF@CIP Gel) were developed for wound management by incorporating antibacterial nanoplatforms (CT-CS-ZIF@CIP) into photocurable gels consisting of chitosan methacrylate and gallic acid grafted gelatin. The nanoplatform was initially constructed by sequentially loading Cu<sub>2</sub>Se (CS) and ciprofloxacin-decorated zeolitic imidazolate framework-8 (ZIF@CIP) onto Cu-doped Ti MOF (CT), in which CS served as a photothermal agent, ZIF enabled pH-responsive release of CIP, and CT acted as carriers for CS and ZIF@CIP. The hydrogel precursor can be sprayed onto wound surface and photocured quickly, allowing hydrogel to fit the wound shape and form a protective barrier onsite. The resultant hydrogel exhibited excellent hemostatic ability, adhesion properties, cytocompatibility and toxin adsorption capacity. By integrating CS for short-term photothermal therapy with CIP for long-acting chemotherapy, the CT-CS-ZIF@CIP Gel demonstrated 100 % sterilization of three bacterial strains. Furthermore, moderate release of zinc and copper ions promoted wound healing. The therapeutic efficacy of hydrogel was validated in an infected cutaneous mouse model. Overall, this work presents a versatile sprayable hydrogel that can be flexibly applied to irregular dynamic wounds for safe and effective wound management.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 123046"},"PeriodicalIF":10.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of β-cyclodextrin polymer nanocomposites exploration for heavy metal removal from wastewater β-环糊精聚合物纳米复合材料在去除废水中重金属方面的探索综述

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-20 DOI: 10.1016/j.carbpol.2024.122981

Youssef Miyah , Noureddine El Messaoudi , Mohammed Benjelloun , Jordana Georgin , Dison Stracke Pfingsten Franco , Mohamed El-habacha , Oumaima Ait Ali , Yaser Acikbas

{"title":"A comprehensive review of β-cyclodextrin polymer nanocomposites exploration for heavy metal removal from wastewater","authors":"Youssef Miyah , Noureddine El Messaoudi , Mohammed Benjelloun , Jordana Georgin , Dison Stracke Pfingsten Franco , Mohamed El-habacha , Oumaima Ait Ali , Yaser Acikbas","doi":"10.1016/j.carbpol.2024.122981","DOIUrl":"10.1016/j.carbpol.2024.122981","url":null,"abstract":"<div><div>This review focuses on the application of β-cyclodextrin (β-CD) polymer nanocomposites (NCs) in the heavy metals (HMs) removal from contaminated water sources. This manuscript's originality consists of an in-depth analysis of recent advances in using β-cyclodextrin nanocomposites (β-CD-NCs) to remove HMs from wastewater, highlighting literature gaps, innovations, and challenges in this field, suggesting perspectives on existing theories, and outlining implications for future research directions. Combining nanoparticles with the β-CD polymer yields stable, reusable β-CD-NCs that are effective and efficient in HM adsorption. The article reviews the various techniques for synthesizing β-CD-NCs and their structural characterization. It also includes processing and functionalization strategies to optimize binding capacity and selectivity for specific HMs. The paper reviews mechanisms underpinning HM adsorption through complexation, ion exchange, and electrostatic interactions. It also reviews how adsorption efficiency is affected by different environmental conditions, such as variations in pH, temperature, and competing ions. This will enable case studies on the applications of β-CD-NCs, particularly for addressing global water pollution. Finally, the current limitations and future perspectives are considered, focusing on the further research needed to optimize these materials for sustainable and cost-effective HM removal on a large scale.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"350 ","pages":"Article 122981"},"PeriodicalIF":10.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thiol-linked hyaluronic acid-mediated encapsulation of RCR-stabilized gold nanoclusters for hyaluronidase sensing and cellular imaging 硫醇连接透明质酸介导的 RCR 稳定金纳米团簇封装，用于透明质酸酶传感和细胞成像

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-19 DOI: 10.1016/j.carbpol.2024.123038

Manivannan Madhu , Meng-Yuan Tsai , Ming-Mu Hsieh , En-Yu Lin , Wei-Bin Tseng , Chi-Yu Lu , Wei-Lung Tseng

{"title":"Thiol-linked hyaluronic acid-mediated encapsulation of RCR-stabilized gold nanoclusters for hyaluronidase sensing and cellular imaging","authors":"Manivannan Madhu , Meng-Yuan Tsai , Ming-Mu Hsieh , En-Yu Lin , Wei-Bin Tseng , Chi-Yu Lu , Wei-Lung Tseng","doi":"10.1016/j.carbpol.2024.123038","DOIUrl":"10.1016/j.carbpol.2024.123038","url":null,"abstract":"<div><div>Encapsulating peptide-stabilized gold nanoclusters (AuNCs) with thiolated hyaluronic acid (HA-SH) and selectively adding cysteine to the peptide sequence increased their photoluminescence. We found that peptide compositions with cysteine in the middle emitted the most. RCR-stabilized AuNCs can be purified using size-exclusion chromatography to characterize their optical characteristics, chemical composition, and possible structure. Our findings show that RCR-stabilized AuNCs have a unique chemical structure, microsecond photoluminescence lifetime, good quantum yield, and near-infrared emission peak. Due to Au-S bonding and electrostatic interactions, RCR-stabilized AuNCs were encapsulated with HA-SH to create nanocomposites. HA-SH-AuNCs had a longer emission peak, greater particle size, and better photostability than RCR-stabilized AuNCs. HAase break down HA in HA-SH-AuNCs, changing their structure and size. Thus, centrifugation makes it easier to separate HA-SH-AuNCs from HAase-digested ones. Similar to earlier sensors, HA-SH-AuNCs have great sensitivity and selectivity for HAase, with a linear range of 0.5–6.0 U/mL and a detection limit of 0.39 U/mL. They were useful for urine HAase determination, with spike recovery of 103 % to 107 %. HA-SH-AuNCs further served as a platform for targeted imaging of CD44 receptor-expressing cancer cells, demonstrating bioimaging and clinical diagnostic potential.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 123038"},"PeriodicalIF":10.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of 3D-printed chitosan‑cerium oxide dressings coated with vancomycin-loaded alginate for chronic wounds management 涂有万古霉素海藻酸盐的 3D 打印壳聚糖-氧化铈敷料在慢性伤口管理中的功效

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-19 DOI: 10.1016/j.carbpol.2024.123036

Sharareh Shahroudi , Amir Parvinnasab , Erfan Salahinejad , Shaghayegh Abdi , Sarah Rajabi , Lobat Tayebi

{"title":"Efficacy of 3D-printed chitosan‑cerium oxide dressings coated with vancomycin-loaded alginate for chronic wounds management","authors":"Sharareh Shahroudi , Amir Parvinnasab , Erfan Salahinejad , Shaghayegh Abdi , Sarah Rajabi , Lobat Tayebi","doi":"10.1016/j.carbpol.2024.123036","DOIUrl":"10.1016/j.carbpol.2024.123036","url":null,"abstract":"<div><div>Multifunctional wound dressings with antibacterial and antioxidant properties hold significant promise for treating chronic wounds; however, achieving a balance of these characteristics while maintaining biocompatibility is challenging. To enhance this balance, this study focuses on the design and development of 3D-printed chitosan-matrix composite scaffolds, which are incorporated with varying amounts of cerium oxide nanoparticles (0, 1, 3, 5, and 7 wt%) and subsequently coated with a vancomycin-loaded alginate layer. The structure, antibiotic drug delivery kinetics, biodegradation, swelling, biocompatibility, antibacterial, antioxidant, and cell migration behaviors of the fabricated dressings were evaluated <em>in-vitro</em>. The findings reveal that all of the formulations demonstrated a robust antibacterial effect against <em>S. aureus</em> bacterial strains in disk diffusion tests. Furthermore, the dressings containing cerium oxide nanoparticles exhibited proper antioxidant capabilities, with over 78.1 % reactive oxygen species (ROS) scavenging efficiency achieved with 7 % cerium oxide nanoparticles. The sample containing 5 % cerium oxide nanoparticles was identified as the optimal formulation, characterized by the most favorable cell biocompatibility, an ROS scavenging ability of over 73.4 %, and the potential to close the wound bed within 24 h. This study highlights that these dressings are promising for managing chronic wounds by preventing infection and oxidative stress in a correct therapeutic sequence.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 123036"},"PeriodicalIF":10.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142704572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the structural properties of three pectin fractions variation affecting pulp browning during peach processing 揭示影响桃加工过程中果肉褐变的三种果胶组分变化的结构特性

IF 10.7 1区化学

Carbohydrate Polymers Pub Date : 2024-11-19 DOI: 10.1016/j.carbpol.2024.123011

Weining Chen, Jinfeng Bi, Wenyue Wang, Xuan Li

{"title":"Unveiling the structural properties of three pectin fractions variation affecting pulp browning during peach processing","authors":"Weining Chen, Jinfeng Bi, Wenyue Wang, Xuan Li","doi":"10.1016/j.carbpol.2024.123011","DOIUrl":"10.1016/j.carbpol.2024.123011","url":null,"abstract":"<div><div>Peach ripening accompanying by processing browning exacerbated has not been clarified in perspective of pectin fractions structural variation. This study investigated pectin fractions of water-soluble (WSP), trans-cyclohexane-1,2-diaminetetraacetic acid-soluble (CSP) and sodium carbonate-soluble (NSP) pectin in peach with different ripening times (24, 48, 72 h) and pretreatments (cold shock, CaCl2, the combination) effect on pulp browning in processing. Results showed that extended ripening time increases browning index and rate, along with increased reactive oxygen species levels, polyphenol oxidase and pectinase activities, and the structural of the pectin fractions. Thereinto, weight-average (Mw) and number-average (Mn) molecular weight of WSP increased, its linearity and branching degree decreased, while CSP and NSP showed decreases in Mw, Mn, and branching degree, but increases in linearity, rhamnogalacturonan structure proportion, and bending degree. Browning was correlated positively with Mn, Mw, rhamnogalacturonan proportion of WSP and CSP, linearity and bending degree of NSP, while negatively correlated with Mw of CSP and NSP and esterification degree and branching of all fractions. Thus, maintaining pectin polydispersity and rhamnogalacturonan branching helps protect the system from being quickly browning by compartmentalization effect of hindering the polyphenol substrates and enzymes possibly effective. This study offers insights into controlling browning through pectin fractions modulation.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 ","pages":"Article 123011"},"PeriodicalIF":10.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0