Carbohydrate Polymers最新文献

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Corrigendum to "Mechanically and functionally strengthened tissue adhesive of chitin whisker complexed chitosan/dextran derivatives based hydrogel" [Carbohydr. Polym. 237 (2020) 116138]. “几丁质须络合壳聚糖/葡聚糖衍生物基水凝胶的机械和功能强化组织粘合剂”的勘误[碳水化合物]。高分子学报,237(2020):116138。
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-15 Epub Date: 2025-06-18 DOI: 10.1016/j.carbpol.2025.123886
Jianhui Pang, Shichao Bi, Tiantian Kong, Xin Luo, Zhongzheng Zhou, Kaijin Qiu, Liang Huang, Xiguang Chen, Ming Kong
{"title":"Corrigendum to \"Mechanically and functionally strengthened tissue adhesive of chitin whisker complexed chitosan/dextran derivatives based hydrogel\" [Carbohydr. Polym. 237 (2020) 116138].","authors":"Jianhui Pang, Shichao Bi, Tiantian Kong, Xin Luo, Zhongzheng Zhou, Kaijin Qiu, Liang Huang, Xiguang Chen, Ming Kong","doi":"10.1016/j.carbpol.2025.123886","DOIUrl":"https://doi.org/10.1016/j.carbpol.2025.123886","url":null,"abstract":"","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"366 ","pages":"123886"},"PeriodicalIF":12.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Doxorubicin delivered by redox-responsive Hyaluronic Acid-Ibuprofen prodrug micelles for treatment of metastatic breast cancer" [Carbohydrate Polymers 245 (2020) 116527]. “透明质酸-布洛芬前药胶束递送多柔比星治疗转移性乳腺癌”[碳水化合物聚合物245(2020)116527]。
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-15 Epub Date: 2025-07-05 DOI: 10.1016/j.carbpol.2025.123941
Zhuodong Chai, Chao Teng, Lei Yang, Lianjie Ren, Zhongyue Yuan, Siyuan Xu, Manman Cheng, Yanmei Wang, Zhen Yan, Chao Qin, Xiaopeng Han, Lifang Yin
{"title":"Corrigendum to \"Doxorubicin delivered by redox-responsive Hyaluronic Acid-Ibuprofen prodrug micelles for treatment of metastatic breast cancer\" [Carbohydrate Polymers 245 (2020) 116527].","authors":"Zhuodong Chai, Chao Teng, Lei Yang, Lianjie Ren, Zhongyue Yuan, Siyuan Xu, Manman Cheng, Yanmei Wang, Zhen Yan, Chao Qin, Xiaopeng Han, Lifang Yin","doi":"10.1016/j.carbpol.2025.123941","DOIUrl":"https://doi.org/10.1016/j.carbpol.2025.123941","url":null,"abstract":"","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"366 ","pages":"123941"},"PeriodicalIF":12.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic stretching-annealing and salting-out enabling ultrastrong, ultratough anisotropic bacterial cellulose conductive hydrogels for bioelectric sensors 协同拉伸退火和盐析使生物电传感器的超强、超韧各向异性细菌纤维素导电水凝胶
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-10 DOI: 10.1016/j.carbpol.2025.124513
Lan Lei, Shuangshuang Hu, Yu Xie, Xiaoxuan Liu, Chunjie Xie, Hui Li
{"title":"Synergistic stretching-annealing and salting-out enabling ultrastrong, ultratough anisotropic bacterial cellulose conductive hydrogels for bioelectric sensors","authors":"Lan Lei,&nbsp;Shuangshuang Hu,&nbsp;Yu Xie,&nbsp;Xiaoxuan Liu,&nbsp;Chunjie Xie,&nbsp;Hui Li","doi":"10.1016/j.carbpol.2025.124513","DOIUrl":"10.1016/j.carbpol.2025.124513","url":null,"abstract":"<div><div>Developing high-performance hydrogels that simultaneously exhibit biocompatibility, exceptional strength, toughness, conductivity, and antibacterial properties is crucial for meeting the stringent demands of bioelectric signal monitoring. Herein, we present an integrated approach for designing anisotropic bacterial cellulose (BC) hydrogels (PBA/K-a%) involving stretching the as-prepared polyvinyl alcohol (PVA)-BC-2-acrylamido-2-methylpropanesulfonic acid (AMPS) hydrogels (PBA) to various elongation ratios (a%), followed by air-drying during annealing to align the polymer chains, and finally immersed in potassium citrate (K<sub>3</sub>Cit) solutions to enhance the polymeric interactions via a synergistic stretching-annealing and salting-out (SSAS) strategy. This effective strategy improves molecular hydrogen and coordination interactions, enhances crystallinity, and induces the orientation of polymer chains and nanofibers along the stretching direction, significantly increasing the mechanical robustness of the hydrogels. Notably, the P<sub>10%</sub>B<sub>0.</sub><sub>45%</sub>A<sub>10%</sub>/K-100 % hydrogel demonstrates ultrahigh mechanical strength of 45.32 MPa, high strain of 838 %, and ultrahigh toughness of 256.26 MJ/m<sup>3</sup>, as well as good conductivity with 13.3 mS/cm. The cooperative incorporation of PAMPS and K<sub>3</sub>Cit endows the hydrogel with good antibacterial capacity, establishing it as a unique and effective wearable sensor. Furthermore, the PBA/K-100 % hydrogel was successfully employed for the bioelectric signal monitoring of electrocardiograms (ECG) and electromyograms (EMG), thus demonstrating its potential applications in human-machine interactions and bioelectronics.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124513"},"PeriodicalIF":12.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional additives to strengthen composite packaging film containing cellulose nanocrystals: Property enhancement and applications in food preservation 增强含纤维素纳米晶复合包装膜的功能性添加剂:性能增强及其在食品保鲜中的应用
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-09 DOI: 10.1016/j.carbpol.2025.124483
Junjie Wu , Qiqi Cui , Si Mi , Wenlong Yu , Yaxin Sang , Xianghong Wang
{"title":"Functional additives to strengthen composite packaging film containing cellulose nanocrystals: Property enhancement and applications in food preservation","authors":"Junjie Wu ,&nbsp;Qiqi Cui ,&nbsp;Si Mi ,&nbsp;Wenlong Yu ,&nbsp;Yaxin Sang ,&nbsp;Xianghong Wang","doi":"10.1016/j.carbpol.2025.124483","DOIUrl":"10.1016/j.carbpol.2025.124483","url":null,"abstract":"<div><div>Petroleum-based polymers have significantly contributed to modern convenience. However, their non-biodegradable nature has led to severe environmental pollution. Cellulose nanocrystals (CNC) have emerged as a novel matrix for eco-friendly packaging materials due to their unique advantageous properties. Furthermore, as technology advances, consumer demands for packaging materials have evolved, requiring enhanced functionality, sustainability, and safety. CNC, derived from native cellulose, exhibit not only superior biodegradability and biocompatibility but also demonstrate high crystallinity and mechanical toughness, thereby significantly enhancing the performance characteristics of composite films. When incorporated into composite systems, CNC form a three-dimensional network structure capable of immobilizing various functional additives—such as inorganic metal nanoparticles or bioactive plant-derived compounds. This uniform dispersion within the matrix imparts advanced functionalities to the resulting films, including antimicrobial and antioxidant properties, while also enabling sustained release mechanisms that prolong their functional lifespan. This review systematically examines the extraction methodologies of CNC, the variety of functional additives incorporated into CNC, and their subsequent impacts on film characteristics. Furthermore, this review summarizes the applications of CNC-enhanced packaging materials in the food industry. CNC-reinforced composite packaging films incorporated with functional additives demonstrate significant potential for use in edible packaging, biodegradable materials, and intelligent packaging systems.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124483"},"PeriodicalIF":12.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An alternative amine protection strategy for chitosan enabling chemoselective modifications 一种使壳聚糖化学选择性修饰的替代胺保护策略
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-09 DOI: 10.1016/j.carbpol.2025.124511
Jun Wang , Qiang Fu , Xiaoxiao Wang , Honglin Zhang , Daoqiang Lu , Xiu Wang , Riwang Li , Dahai Liu
{"title":"An alternative amine protection strategy for chitosan enabling chemoselective modifications","authors":"Jun Wang ,&nbsp;Qiang Fu ,&nbsp;Xiaoxiao Wang ,&nbsp;Honglin Zhang ,&nbsp;Daoqiang Lu ,&nbsp;Xiu Wang ,&nbsp;Riwang Li ,&nbsp;Dahai Liu","doi":"10.1016/j.carbpol.2025.124511","DOIUrl":"10.1016/j.carbpol.2025.124511","url":null,"abstract":"<div><div>The trifluoroacetyl group is a widely used and easily removable amino-protecting group, making it an ideal choice for protecting the amino groups of chitosan. However, current methods for trifluoroacetylation of chitosan suffer from low reaction efficiency and limited modification degrees, posing a persistent challenge for achieving complete <em>N</em>-trifluoroacetylation. In this study, a simple and efficient method for preparing amino-protected chitosan, specifically <em>N</em>-trifluoroacetyl chitosan, is presented. The process is carried out in a homogeneous solution at room temperature, without the need for stringent anhydrous or oxygen-free conditions, and involves a brief reaction time. <em>N</em>-trifluoroacetyl chitosan exhibits good solubility in organic solvents, enabling homogeneous reactions with reagents such as enol ethers or <em>t</em>-butyldimethylchlorosilane. Furthermore, the protecting group can be easily removed under mild conditions. This method for amino group protection in chitosan offers a convenient approach for subsequent modifications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124511"},"PeriodicalIF":12.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tunable-pore cellulose microsphere adsorbents for column adsorption of dyes 用于染料柱吸附的可调孔纤维素微球吸附剂
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-07 DOI: 10.1016/j.carbpol.2025.124507
Guancheng Liu, Zhe Zhang, Xin Long, Kai Zhang, Yunfeng Li, Bai Yang
{"title":"Tunable-pore cellulose microsphere adsorbents for column adsorption of dyes","authors":"Guancheng Liu,&nbsp;Zhe Zhang,&nbsp;Xin Long,&nbsp;Kai Zhang,&nbsp;Yunfeng Li,&nbsp;Bai Yang","doi":"10.1016/j.carbpol.2025.124507","DOIUrl":"10.1016/j.carbpol.2025.124507","url":null,"abstract":"<div><div>The pore structure of cellulose microspheres is vital for their adsorption performance, however it is still challenge to control pore size and their distribution by a simple and cost-effective method. Here, through adjusting volume ratios of ethylene glycol diacetate to n-octanol in the cellulose solution, we prepare cellulose microspheres with adjustable pore size ranging from the micron- to nanometer scale in a straightforward and scalable method. We show that the average diameter of pores in cellulose microspheres is controlled from 4.58 μm to 108.43 nm with the median of pore diameter being from 1.63 μm to 7.69 nm. Cellulose microspheres exhibited good performance in both static and dynamic adsorption of methylene blue dye with a maximum capacity of 20.6 mg/g. A monolayer adsorption mechanism is revealed through fitting the Langmuir isotherm model. Interestingly, cellulose microspheres exhibit compressive strength comparable to that of adsorption resins, with maximum compressive stress ranging from 5.25 to 52.1 MPa, enabling them to pack in adsorption columns. Notably, a removal efficiency of 94.1 % was achieved by using column adsorption. Cellulose microspheres show adjustable pore size, good mechanical properties, and good adsorption performance, which will accelerate their practical applications in the environmental remediation.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124507"},"PeriodicalIF":12.5,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mannose-modified Prunus persica kernel protein nanoparticles loading baicalin coated with Lycium barbarum polysaccharide for ulcerative colitis treatment 甘露糖修饰的桃核蛋白纳米颗粒载黄芩苷包被枸杞多糖治疗溃疡性结肠炎
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-06 DOI: 10.1016/j.carbpol.2025.124489
Chunxiao Tao , Fazhen Luo , Yaxin Wang , Xiaoya Gao , Yuqi Cao , Keke Wang , Yan Xie
{"title":"Mannose-modified Prunus persica kernel protein nanoparticles loading baicalin coated with Lycium barbarum polysaccharide for ulcerative colitis treatment","authors":"Chunxiao Tao ,&nbsp;Fazhen Luo ,&nbsp;Yaxin Wang ,&nbsp;Xiaoya Gao ,&nbsp;Yuqi Cao ,&nbsp;Keke Wang ,&nbsp;Yan Xie","doi":"10.1016/j.carbpol.2025.124489","DOIUrl":"10.1016/j.carbpol.2025.124489","url":null,"abstract":"<div><div>Baicalin (Ba) is a promising anti-inflammatory agent for treating ulcerative colitis (UC), but its efficacy is constrained by poor solubility and colon-targeting efficiency. <em>Lycium barbarum</em> polysaccharide (LBP), an anionic polysaccharide, not only restores gut microbiota dysbiosis but also exhibits excellent upper gastrointestinal stability and biocompatibility, making it a candidate for developing colon-targeted carriers. In this paper, the polymeric nanoparticles (Ba@MP/LBP NPs) were constructed using LBP, mannose, and <em>Prunus persica</em> kernel protein (PKP) for targeted delivery of baicalin to enhance its efficacy in UC treatment. The obtained Ba@MP/LBP NPs possessed core-shell spherical morphology, narrow particle-size distribution (∼230 nm), negative surface charge (−33.89 mV), and excellent baicalin encapsulation (94.26 %). With the aid of the LBP coating, Ba@MP/LBP NPs can tolerate upper gastrointestinal disturbances and transport Ba@MP NPs into colon, thereby facilitating baicalin uptake by inflammatory macrophages via mannose receptor-mediated endocytosis. Furthermore, the LBP coating strengthened Ba@MP NPs' ability to regulate the intestinal flora; hence, Ba@MP/LBP NPs can restore gut microbiota balance while suppressing pro-inflammatory factor secretion and oxidative stress, ultimately alleviating UC. More importantly, Ba@MP/LBP NPs exhibited favorable biosafety. Overall, this work is the first attempt to employ LBP and PKP as colon-targeting carriers, providing a promising nanomedicine for UC therapy.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124489"},"PeriodicalIF":12.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hofmeister effect-regulated poly(vinyl alcohol) @ cellulose nanofiber hydrogel-based SERS enhancement and sensing application Hofmeister效应调控聚乙烯醇@纤维素纳米纤维水凝胶基SERS增强及传感应用
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-06 DOI: 10.1016/j.carbpol.2025.124498
Changyan Tan , Rui Li , Qin Yang , Lu Xue , Yong Ye , Ji Zhou , Ning Lin
{"title":"Hofmeister effect-regulated poly(vinyl alcohol) @ cellulose nanofiber hydrogel-based SERS enhancement and sensing application","authors":"Changyan Tan ,&nbsp;Rui Li ,&nbsp;Qin Yang ,&nbsp;Lu Xue ,&nbsp;Yong Ye ,&nbsp;Ji Zhou ,&nbsp;Ning Lin","doi":"10.1016/j.carbpol.2025.124498","DOIUrl":"10.1016/j.carbpol.2025.124498","url":null,"abstract":"<div><div>Owing to high water absorption and molecular capture capabilities, hydrogels are ideal substrates for integrating with metal nanoparticles and widely used in surface-enhanced Raman scattering (SERS) sensing. Herein, a strategy is proposed to versatilely alter the SERS properties of hydrogels by tuning the aggregation states of polymer chains through ion-specific effects derived from the Hofmeister series. A polyvinyl alcohol@cellulose nanofiber/silver nanoparticle (PVA@CNF/Ag NPs) hybrid hydrogel was fabricated, incorporating both sulfate and nitrate anions into this hydrogel with enhancement of SERS signals. The kosmotropic Na<sub>2</sub>SO<sub>4</sub> drives chain bundling in the PVA@CNF hydrogel matrix, thereby indirectly modulating the interparticle distance of Ag NPs therein. This facilitates the formation of electromagnetic “hot spots”, resulting in a marked improvement in SERS performance. Furthermore, the SERS performance of the hydrogels can be readily tuned across a broad range via adjusting anion type, concentration, and treatment duration. The optimal hydrogel exhibits a linear detection range of 0.001–100 ppm for methamphetamine (MAMP), with a coefficient of determination (R<sup>2</sup>) of 0.9836. When applied to urine analysis, it shows 85–110 % recoveries and a relative standard deviation (RSD) ~ 10 %. We further developed an indirect quantitative method for glucose, which features a lower limit of detection (10<sup>−7</sup> M).</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124498"},"PeriodicalIF":12.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A facile microfluidics based polysaccharide-functionalized virus-mimicking nanovaccine for circumventing pulmonary innate physiological barriers and augmenting immunity 一种基于微流体的易操作的多糖功能化病毒模拟纳米疫苗,可绕过肺部先天生理屏障并增强免疫力
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-06 DOI: 10.1016/j.carbpol.2025.124503
Zhixiang CUI , Yalin AN , Zhe Lou , Qiyao ZHAI , Mengmeng YUE , Lu QIN , Renfang ZHU , Ye YUAN , Hezhi WANG , Haiyan SUN , Xuanguang ZHAN , Le SUN , Youcheng GU , Jinlin SONG , Chang LIU , Jian GUAN , Xin ZHANG , Shirui MAO
{"title":"A facile microfluidics based polysaccharide-functionalized virus-mimicking nanovaccine for circumventing pulmonary innate physiological barriers and augmenting immunity","authors":"Zhixiang CUI ,&nbsp;Yalin AN ,&nbsp;Zhe Lou ,&nbsp;Qiyao ZHAI ,&nbsp;Mengmeng YUE ,&nbsp;Lu QIN ,&nbsp;Renfang ZHU ,&nbsp;Ye YUAN ,&nbsp;Hezhi WANG ,&nbsp;Haiyan SUN ,&nbsp;Xuanguang ZHAN ,&nbsp;Le SUN ,&nbsp;Youcheng GU ,&nbsp;Jinlin SONG ,&nbsp;Chang LIU ,&nbsp;Jian GUAN ,&nbsp;Xin ZHANG ,&nbsp;Shirui MAO","doi":"10.1016/j.carbpol.2025.124503","DOIUrl":"10.1016/j.carbpol.2025.124503","url":null,"abstract":"<div><div>The escalating prevalence of COVID-19 variants and influenza has garnered substantial attention to lung vaccines lately. Nevertheless, the intrinsic immune barriers present within the lung significantly tend to compromise the efficacy of nanovaccines. Moreover, the deficiency of safe and efficacious inhalable adjuvants also impedes the advancement of nanovaccines. Herein, we devised polysaccharide-functionalized virus-mimicking nanovaccines via a facile microfluidics approach, wherein chitosan-based polyelectrolyte complexes serve as the inner core (CS-OVA), and heparan sulfate (SH) modification further emulates the structure and composition of the viral exterior. Compared to CS-OVA, SH/CS-OVA revealed remarkable efficacy in surmounting pulmonary physiological barriers, demonstrating a 3-fold enhancement in traversing the mucus lining and a 4.8-fold increase in evading macrophage engulfment. It has also been substantiated to exhibit exceptional in vivo dendritic cell (DC) recruitment and uptake, accompanied by enhanced DC maturation capabilities over CS-OVA. Furthermore, in vivo imaging uncovered significantly prolonged lung retention and rapid lymph nodes drainage. Notably, SH/CS-OVA elicited elevated levels of specific serum IgG and isotype titers, initiating potent T cell and triple immune responses, along with the robust T cell immune memory upon intrapulmonary administration. In summary, the polysaccharide-functionalized virus-mimicking nanovaccine (SH/CS-OVA) presents a safe and effective nanotherapeutics platform for inhaled immunotherapy.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124503"},"PeriodicalIF":12.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulating supramolecular structure to enhance the ductility of regenerated cellulose films from ionic liquid solution 调节超分子结构以提高离子液体再生纤维素膜的延展性
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-06 DOI: 10.1016/j.carbpol.2025.124506
Yuanhao Li , Guangjie Song , Yoshiharu Nishiyama , Jun Zhang
{"title":"Regulating supramolecular structure to enhance the ductility of regenerated cellulose films from ionic liquid solution","authors":"Yuanhao Li ,&nbsp;Guangjie Song ,&nbsp;Yoshiharu Nishiyama ,&nbsp;Jun Zhang","doi":"10.1016/j.carbpol.2025.124506","DOIUrl":"10.1016/j.carbpol.2025.124506","url":null,"abstract":"<div><div>Regenerated cellulose films suffer from inherent brittleness, restricting their practical use. Conventional plasticizer-based strategies can enhance ductility; however, plasticizer migration is an issue. Regulating supramolecular structure during processing is an alternative. We investigated the influence of coagulation bath temperature and coagulant types on the microstructure and mechanical properties of regenerated cellulose films using 1-allyl-3-methylimidazolium chloride (AmimCl) ionic liquid. The regeneration bath at 30 °C yielded hydrogels with a fine, dense, uniform network compared to those at 60 °C or 90 °C. Simple drying of the uniform network resulted in films with increased elongation at break (~15 %) while maintaining high tensile strength (~150 MPa). Solvent exchange to ethanol prior to drying preserved the hydrogel network, yielding dry films with elongation at break up to 30 % and a tensile strength above 100 MPa. This property of film is related to the nanoscale structural heterogeneity: (1) a fine, dense and uniform network formed in the hydrogel; (2) lower density and hence looser packing due to the lower surface tension of ethanol. Thus, controlling coagulation conditions can effectively tailor nanoscale structural heterogeneity to significantly enhance ductility.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"371 ","pages":"Article 124506"},"PeriodicalIF":12.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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