Carbohydrate Polymers最新文献_第5页

Switching cell wall-bound polysaccharides to secreted polysaccharides in lactobacilli 将细胞壁结合的多糖转化为乳酸菌分泌的多糖

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-01-28 DOI: 10.1016/j.carbpol.2026.125030

Saulius Kulakauskas , Irina Sadovskaya , Evgeny Vinogradov , Emmanuel Maes , Pascal Quénée , Laura Alfonsi , Pascal Courtin , Victoria Chuat , Florence Valence , Gwenaëlle André , Christine Péchoux , Lydie Oliveira-Correia , Céline Henry , Pierre Renault , Marie-Pierre Chapot-Chartier

{"title":"Switching cell wall-bound polysaccharides to secreted polysaccharides in lactobacilli","authors":"Saulius Kulakauskas , Irina Sadovskaya , Evgeny Vinogradov , Emmanuel Maes , Pascal Quénée , Laura Alfonsi , Pascal Courtin , Victoria Chuat , Florence Valence , Gwenaëlle André , Christine Péchoux , Lydie Oliveira-Correia , Céline Henry , Pierre Renault , Marie-Pierre Chapot-Chartier","doi":"10.1016/j.carbpol.2026.125030","DOIUrl":"10.1016/j.carbpol.2026.125030","url":null,"abstract":"<div><div>Bacterial exopolysaccharides (EPS) are carbohydrate polymers secreted into the environment. EPS produced by lactic acid bacteria have many valuable properties in the food and health sectors. In this study, we isolated spontaneous mutants of lactobacilli that overproduce EPS, using a selection method based on their slow sedimentation rate in a semi-liquid medium. In the mutants selected from several strains, we detected a missense mutation in <em>epsD</em>, which encodes a tyrosine kinase, or an insertion in <em>epsC</em>, which encodes its transmembrane modulator. Both genes were located within a gene cluster involved in Wzy-dependent polysaccharide biosynthesis. We then characterized selected <em>Lacticaseibacillus rhamnosus</em> mutants in detail to gain insights into the mechanisms involved in EPS overproduction. We demonstrated that the single mutation D94L in the EpsD catalytic site prevents EpsD autophosphorylation. The chemical structure of the overproduced EPS was established, and consists of heptasaccharide repeating units with pyruvate substituents. In the wild-type parental strain, a polysaccharide with an identical structure was found covalently bound to the cell wall (CW) and covering the bacterial surface. In conclusion, our results indicate that the switch from CW-bound polysaccharides to EPS released into the environment is associated with a defect in autophosphorylation of the EpsD tyrosine kinase.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125030"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xanthan gum-walnut protein interactions: The influence of pyruvate groups on xanthan gum side chains 黄原胶-核桃蛋白相互作用：丙酮酸基团对黄原胶侧链的影响

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-02-10 DOI: 10.1016/j.carbpol.2026.125087

Zinuo An , Wensheng Liang , Zhenbin Liu , Hongbo Li , Jiayi Zhang , Lishan Yao , Lu Tian , Xiaolin Zhu , Haizhen Mo , Liangbin Hu

{"title":"Xanthan gum-walnut protein interactions: The influence of pyruvate groups on xanthan gum side chains","authors":"Zinuo An , Wensheng Liang , Zhenbin Liu , Hongbo Li , Jiayi Zhang , Lishan Yao , Lu Tian , Xiaolin Zhu , Haizhen Mo , Liangbin Hu","doi":"10.1016/j.carbpol.2026.125087","DOIUrl":"10.1016/j.carbpol.2026.125087","url":null,"abstract":"<div><div>Understanding the interaction between xanthan gum (XG) and plant protein is crucial for developing dysphagia diets. XG is a key ingredient in many thickeners designed for this purpose, in which the pyruvate group plays an important role. Despite this, little attention has been paid to how the pyruvate group affects the XG-protein interaction. Here, walnut protein isolate (WP) was blended with XG samples spanning a pyruvate gradient (4.42%, 2.47%, and 0.17% for XG, XG<sub>1</sub>, and XG<sub>2</sub>, respectively). Decreasing pyruvate markedly reduced thickening capacity, with viscosity dropping from 32.85 Pa·s (XG) to 22.70 Pa·s (XG<sub>1</sub>; −30.9%) and 4.96 Pa·s (XG<sub>2</sub>; −84.9%). WP-XG mixtures showed 30.87, 18.43, and 4.95 Pa·s for WP-XG, WP-XG<sub>1</sub>, and WP-XG<sub>2</sub>, respectively, indicating the strongest elasticity reinforcement at intermediate pyruvate substitution. Macroscale tribology showed higher friction after de-pyruvylation (μ = 0.51, 0.64, and 0.65), while colloidal results indicated smaller composites with stable surface charges (Zeta potentials −38.00 to −35.67 mV). Spectroscopic and thermal analyses supported the strongest intermolecular network at partial de-pyruvylation, and molecular simulations further indicated substitution- and subunit-dependent binding, with the highest affinity for 11S-XG (−8.9 kcal·mol<sup>−1</sup>). This study would provide a theoretical foundation for the development of XG-regulated plant protein products with desirable performances.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125087"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the influence of solubility and spinnability of alginate in a ternary solvent system 绘制海藻酸盐在三元溶剂体系中溶解度和可纺性的影响图

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-02-05 DOI: 10.1016/j.carbpol.2026.125062

Sijia Kang , Seda Gungordu Er , Shervanthi Homer-Vanniasinkam , Mohan Edirisinghe

{"title":"Mapping the influence of solubility and spinnability of alginate in a ternary solvent system","authors":"Sijia Kang , Seda Gungordu Er , Shervanthi Homer-Vanniasinkam , Mohan Edirisinghe","doi":"10.1016/j.carbpol.2026.125062","DOIUrl":"10.1016/j.carbpol.2026.125062","url":null,"abstract":"<div><div>This study presents a scalable strategy for designing the morphology of polysaccharides for applications in food, biomedical fields, and additive manufacturing. An adjustable ternary supramolecular formulation framework consisting of ethanol, glycerol, and water, designed to steer pure sodium alginate (SA) electrohydrodynamic (EHD) forming of fine structures ranging from discrete beads to continuous microribbons is uncovered. The engineered formulation provides enhanced control over solvent composition and solution parameters, including ternary solvent content, and establishes a ternary processing window of 2.0–2.3% w/v alginate, 10–15% v/v ethanol, and 8–12% v/v glycerol, with a zero-shear viscosity (η₀) ranging from 1.2 to 3.0 × 10⁴ mPa s. Within this window, pure alginate microribbons with a minimal diameter of 26.5 μm and aspect ratio between 10 and 20 were achieved. The length and aspect ratio of the microribbons are governed by the alginate concentration, as well as the water and ethanol contents, suggesting opportunities for future research into customized structural optimization tailored to specific target applications. Furthermore, precise control over the synthesis process and solution ratio optimization for pure alginate demonstrates the feasibility of alginate EHD forming, yielding micrometer-scale core-sheath architectures with promising potential for environmentally friendly, sustainable, and pollution-free applications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125062"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pullulan-based bilayer film for buccal delivery of a GLP-1 peptide analogue 一种基于普鲁兰的双层膜，用于口腔递送GLP-1肽类似物

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-02-09 DOI: 10.1016/j.carbpol.2026.125064

Sandeep Karki , Sahil Malhotra , Muhammad Ijaz , Nicolas Rollet , Eoin D. O'Cearbhaill , Estela Bini , David J. Brayden

{"title":"A pullulan-based bilayer film for buccal delivery of a GLP-1 peptide analogue","authors":"Sandeep Karki , Sahil Malhotra , Muhammad Ijaz , Nicolas Rollet , Eoin D. O'Cearbhaill , Estela Bini , David J. Brayden","doi":"10.1016/j.carbpol.2026.125064","DOIUrl":"10.1016/j.carbpol.2026.125064","url":null,"abstract":"<div><div>The buccal route has re-emerged as an alternative non-injectable route for peptide delivery. However, buccal peptide bioavailability is low, necessitating new formulation strategies. Pullulan, a water-soluble carbohydrate polymer, offers potential as a film-forming agent for buccal peptide delivery. Our aim was to co-administer a glucagon-like peptide-1 receptor agonist (GLP-1 RA) model analogue with an epithelial permeation enhancer, sodium glycodeoxycholate (GDC) in a bilayer film using a pullulan-based mucoadhesive layer. A pullulan–carboxymethyl cellulose mucoadhesive layer was selected, along with a backing layer made from an ammonio-methacrylate copolymer (Eudragit® RLPO). Physicochemical characterization confirmed the suitability of the pullulan-based film for buccal application. A Hilltop Chamber comprising an adhesive-backed cotton pad identified an optimal GLP-1 RA:GDC ratio for peptide permeation across <em>ex vivo</em> porcine buccal mucosae. 200 mM GDC (94.4 mg/mL) enabled ∼6% flux at 3 h using a donor concentration of 50 mg/mL GLP-1 RA (∼1:2). When these concentrations were incorporated into the prototype pullulan films, GLP-1 RA fluxes across mucosae reached ∼4.5% and ∼2% at 3 h for single mucoadhesive-layer and bilayer films, respectively, without overt tissue damage. Integrating GLP-1 RA and GDC into a pullulan–based bilayer film offers a promising carbohydrate polymer platform for enhancing buccal peptide delivery.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125064"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailoring cellulose hydrogel electrolyte using deep eutectic solvent for stable zinc-ion hybrid supercapacitors with enhanced ionic transport 裁剪纤维素水凝胶电解质使用深共熔溶剂稳定锌离子混合超级电容器与增强离子传输

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-01-31 DOI: 10.1016/j.carbpol.2026.125026

Yunhua Bai, Xiong-Fei Zhang, Hu Liu, Yafen Li, Xiaoli Gu, Jianfeng Yao

{"title":"Tailoring cellulose hydrogel electrolyte using deep eutectic solvent for stable zinc-ion hybrid supercapacitors with enhanced ionic transport","authors":"Yunhua Bai, Xiong-Fei Zhang, Hu Liu, Yafen Li, Xiaoli Gu, Jianfeng Yao","doi":"10.1016/j.carbpol.2026.125026","DOIUrl":"10.1016/j.carbpol.2026.125026","url":null,"abstract":"<div><div>Zinc-ion hybrid supercapacitors (ZHSs) are considered promising candidates for large-scale energy storage because of their low cost, high safety, and excellent power density. However, in practical applications, the capacity and cycling stability of zinc-ion capacitors are hindered by issues such as dendrite growth and parasitic side reactions. This inherently requires the gel electrolyte to possess excellent mechanical strength and tunable interfacial properties to effectively regulate the electrochemical deposition of zinc. We developed a cellulose-based hydrogel (DES-gel-2) electrolyte prepared via NaOH–urea treatment followed by immersion in a ZnCl<sub>2</sub>/urea deep eutectic solvent (DES). The experimental results indicate that urea molecules in DES-gel-2 coordinate with Zn<sup>2+</sup> and water molecules, leading to a more uniform Zn<sup>2+</sup> electric field distribution and effectively suppressing Zn dendrite growth. Meanwhile, residual Na<sup>+</sup> ions in the hydrogel electrolyte enhance ionic conductivity and facilitate fast interfacial charge transport, thereby improving electrochemical kinetics. The ZHS based on DES-gel-2 retained over 86.7% of its capacity after 10,000 cycles at a high current density of 10 A·g<sup>−1</sup>, demonstrating excellent cycling stability. This study presents a novel and effective strategy for regulating Zn deposition behavior through DES-cellulose hydrogel electrolytes, offering new opportunities for the development of high-performance zinc-based energy storage systems.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125026"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Escherichia coli to biosynthesize O-polysaccharide-derived recombinant Glycoconjugate vaccines against pathogenic serotypes O8 and O9a 工程大肠杆菌生物合成o -多糖来源的重组糖结合疫苗，抗致病性血清型O8和O9a

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-01-26 DOI: 10.1016/j.carbpol.2026.125009

Ziyu Li , Guozhen Ma , Ruiying Liu , Xiaohan Wang , Yujie Wang , Xiaojing Zhao , Qing Meng , Lijie Xie , Xiaoya Li , Sijia Liu , Huilin Hao , Xiaolong Jiang , Di Huang

{"title":"Engineering Escherichia coli to biosynthesize O-polysaccharide-derived recombinant Glycoconjugate vaccines against pathogenic serotypes O8 and O9a","authors":"Ziyu Li , Guozhen Ma , Ruiying Liu , Xiaohan Wang , Yujie Wang , Xiaojing Zhao , Qing Meng , Lijie Xie , Xiaoya Li , Sijia Liu , Huilin Hao , Xiaolong Jiang , Di Huang","doi":"10.1016/j.carbpol.2026.125009","DOIUrl":"10.1016/j.carbpol.2026.125009","url":null,"abstract":"<div><div>The development of effective vaccines against extraintestinal pathogenic <em>Escherichia coli</em> (ExPEC) serotypes O8 and O9a remains an unmet medical need. We established a sustainable biomanufacturing platform for glycoconjugate vaccines by engineering an <em>E. coli</em> chassis strain with optimized nucleotide sugar precursor supply and enhanced O-polysaccharide (OPS) biosynthesis. Genes related to competitive and catabolic pathways (<em>gnd-rfbB</em>, <em>wcaM–wcaJ</em> and <em>wcaI–wza</em>, <em>glgC</em>, <em>ushA</em>, <em>pfkA/B</em>) were systematically deleted using CRISPR-Cas9 and λ-RED genome editing, while the phosphotransferase system gene <em>ptsA</em> was overexpressed, yielding chassis strain EG01. This rational metabolic engineering increased O8- and O9a-OPS yields by 2.11-fold and 2.4-fold, respectively. Co-expression of <em>Neisseria meningitidis</em> glycosyltransferase PglL and carrier protein CTB enabled efficient protein glycosylation, improving conjugate yields by 2.59-fold (O8) and 4.18-fold (O9a) versus wild-type. Mass spectrometry confirmed site-specific O-glycosylation at CTB Thr19 with preserved OPS repeat-unit structure. The vaccine candidate demonstrated a favorable safety profile in mice, inducing only transient cytokine responses without systemic toxicity. Immunization elicited robust, durable Th1-biased IgG responses, conferring 80–90% protection against lethal challenge and significantly reducing bacterial loads in vivo. This work establishes an efficient, scalable glycoconjugate vaccine production platform, highlighting a promising metabolic engineering strategy to combat ExPEC infections.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125009"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing cyclodextrins for enhanced CO2 management: Recent advances and perspectives for sustainable applications 利用环糊精加强二氧化碳管理：可持续应用的最新进展和前景

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-02-06 DOI: 10.1016/j.carbpol.2026.125071

Ahmed Hazem Abdelhay, Aymen S. Abu Hatab, Abdulilah Dawoud Bani-Yaseen

{"title":"Harnessing cyclodextrins for enhanced CO2 management: Recent advances and perspectives for sustainable applications","authors":"Ahmed Hazem Abdelhay, Aymen S. Abu Hatab, Abdulilah Dawoud Bani-Yaseen","doi":"10.1016/j.carbpol.2026.125071","DOIUrl":"10.1016/j.carbpol.2026.125071","url":null,"abstract":"<div><div>The critical need to address increasing atmospheric CO<sub>2</sub> levels has motivated efforts to develop sustainable materials for carbon capture, utilization and storage (CCUS). Cyclodextrins (CDs) have emerged as practical and versatile candidates for improving CO<sub>2</sub> handling due to their naturally occurring macrocyclic structures. CDs possess tunable hydrophobic interiors and hydrophilic exteriors that enable efficient host-guest chemistry. This review highlights the potential of CDs to overcome traditional limitations in CCUS through supramolecular interactions. In capture applications, CD-based systems exhibit reversible CO<sub>2</sub> binding through combined chemisorption and physisorption mechanisms. For gas separation, CD-functionalized membranes and composite porous materials enhance selectivity via molecular sieving and anti-plasticization effects, with some systems showing no apparent permeability selectivity trade-offs. In catalytic conversion, CDs facilitate metal-free reactions that transform CO<sub>2</sub> into value added products under moderate conditions. Despite advantages including biocompatibility, structural tunability, and green synthesis, CD-based platforms face challenges related to scalability, mechanical stability in operating fluids, and long-term deactivation. This review consolidates current advances in CD host chemistry and materials science to bridge laboratory developments and practical CCUS implementation. Addressing issues of scalable synthesis, energy efficient regeneration, and operational stability is therefore the key to transitioning CD-based materials from the laboratory to practical CCUS applications.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125071"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An arabinogalactan from Bupleurum chinense DC. attenuates LPS-induced inflammation in RAW264.7 macrophages 源自中国柴胡的阿拉伯半乳。减轻lps诱导的RAW264.7巨噬细胞炎症

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-02-03 DOI: 10.1016/j.carbpol.2026.125053

Bowen Zheng , Chenxu Jiang , Zheng Wang , Qiuhong Zhang , Hang Du , Nana Huang , Jin Wang , Jinhua Du , Daizhou Zhang , Rong Sun , Daijie Wang

{"title":"An arabinogalactan from Bupleurum chinense DC. attenuates LPS-induced inflammation in RAW264.7 macrophages","authors":"Bowen Zheng , Chenxu Jiang , Zheng Wang , Qiuhong Zhang , Hang Du , Nana Huang , Jin Wang , Jinhua Du , Daizhou Zhang , Rong Sun , Daijie Wang","doi":"10.1016/j.carbpol.2026.125053","DOIUrl":"10.1016/j.carbpol.2026.125053","url":null,"abstract":"<div><div>Inflammation is a fundamental defense mechanism of the human body, but its dysregulation can lead to chronic disease. Therefore, identifying natural compounds with anti-inflammatory potential has become particularly important. Natural polysaccharides have received increased interest due to their immunomodulatory and anti-inflammatory effects. In this study, we characterized the structure of an arabinogalactan (BCP-WB) derived from <em>Bupleurum chinense</em> DC. (Apiaceae family) with a widely used medicinal plant. Its molecular weight was determined to be 34.4 kDa. Its backbone is predominantly made up of →6)-β-D-Galp-(1→, →3,6)-β-D-Galp-(1 → and →6)-α-D-Glcp-(1 → linkages, while the side chains are formed by α-L-Araf-(1→, →5)-α-L-Araf-(1 → and →3,5)-α-L-Araf-(1 → linkages. The anti-inflammatory activities of BCP-WB were evaluated in LPS-induced RAW264.7 cells and CuSO<sub>4</sub>-induced zebrafish. BCP-WB significantly alleviates inflammatory reaction, including neutrophil dispersion, NO release, and inflammatory cytokine production. Mechanistically, RNA-seq analysis revealed that BCP-WB induces extensive transcriptional reprogramming in macrophages, including downregulation of NF-κB, TNF, and cell cycle pathways. Guided by these findings, BCP-WB was further demonstrated to bind directly to TLR4, as validated by molecular docking and SPR assays, which provided kinetic evidence of receptor engagement. This interaction ultimately suppresses the activation of NF-κB and MAPK signaling cascades, thereby attenuating inflammatory responses at multiple levels.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125053"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-Cyclodextrin-functionalized Zr-sulfonamide MOF novel pH-responsive nano platform for breast and lung cancer β-环糊精功能化zr -磺酰胺MOF新型ph响应型乳腺癌和肺癌纳米平台

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-01-21 DOI: 10.1016/j.carbpol.2026.124971

Sedigheh Alavinia , Ramin Ghorbani-Vaghei , Katayoun Derakhshandeh , Nafiseh Emami , Seyed Sepehr Uroomiye , Milad Babaei

{"title":"β-Cyclodextrin-functionalized Zr-sulfonamide MOF novel pH-responsive nano platform for breast and lung cancer","authors":"Sedigheh Alavinia , Ramin Ghorbani-Vaghei , Katayoun Derakhshandeh , Nafiseh Emami , Seyed Sepehr Uroomiye , Milad Babaei","doi":"10.1016/j.carbpol.2026.124971","DOIUrl":"10.1016/j.carbpol.2026.124971","url":null,"abstract":"<div><div>Despite significant advancements in cancer therapies, lung and breast cancers continue to pose serious challenges, remaining among the most prevalent and lethal forms of the disease. This study investigates an innovative approach to enhance drug delivery and treatment efficacy through the synthesis of sulfonamide UiO-MOF (Metal-Organic Framework) and its derivative, Sul-UiO-MOF-ABA-β-cyclodextrin, specifically designed for the loading of paclitaxel (PTX). The unique synergy of β-cyclodextrin and a sulfonamide MOF significantly improves PTX loading and enhances therapeutic effectiveness, demonstrating considerable potential for cancer treatment.</div><div>Our findings indicate that the PTX@3 T formulation exhibits a remarkable pH-responsive release profile, with 84.16% of the drug released at a reduced pH of 5.3, conforming to first-order kinetic models. The entrapment efficiencies for PTX@2 T and PTX@3 T were notable at 70.3% and 90.25%, respectively. In efficacy tests on the MCF-7 breast cancer cell line, the IC50 values for PTX, PTX@2 T, and PTX@3 T were 24.91, 9.87, and 10.00 μg/mL, respectively, correlating with apoptosis rates of 31.14%, 70.68%, and 96.56%. Similarly, for the A-549 lung cancer cell line, the IC50 values were 9.75, 1.82, and 5.86 μg/ml, with apoptosis rates of 38.25%, 10.55%, and 11.50%, respectively.Importantly, Sul-UiO-MOF and Sul-UiO-MOF-ABA-βCD demonstrated excellent biocompatibility, maintaining approximately 100% cell viability in HEK293 cells after 48 h, indicating a favorable safety profile for therapeutic use. Thus, PTX@3 T emerges as a compelling “smart” drug delivery system, offering a promising avenue for improved cancer therapy that warrants further investigation.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 124971"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polysaccharide-based inflammatory microenvironment-responsive nanocarriers for ulcerative colitis: Advances in design, mechanisms, and therapeutic applications 溃疡性结肠炎的基于多糖的炎症微环境反应纳米载体：设计、机制和治疗应用的进展

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-15 Epub Date: 2026-02-04 DOI: 10.1016/j.carbpol.2026.125069

Si-Jie Wu , Ran Feng , Ran Meng , Qiu-Ya Ji , Han Tao , Bao-Cai Xu , Bao Zhang

{"title":"Polysaccharide-based inflammatory microenvironment-responsive nanocarriers for ulcerative colitis: Advances in design, mechanisms, and therapeutic applications","authors":"Si-Jie Wu , Ran Feng , Ran Meng , Qiu-Ya Ji , Han Tao , Bao-Cai Xu , Bao Zhang","doi":"10.1016/j.carbpol.2026.125069","DOIUrl":"10.1016/j.carbpol.2026.125069","url":null,"abstract":"<div><div>The worldwide incidence of ulcerative colitis (UC) continues to rise, presenting a growing public health challenge due to its multifactorial etiology and limited therapeutic options. While current therapeutic regimens can alleviate symptoms, they are plagued by constrained efficacy and significant side effects. Advances in nanotechnology have catalyzed the development of polysaccharide-based inflammatory microenvironment-responsive nanocarriers (PIMRNs), offering novel opportunities for UC management. PIMRNs exhibit excellent bioactivity, biocompatibility, and multifunctional modulation capabilities. Their structural design enables precise targeting and spatiotemporally controlled drug release, which can be specifically triggered by the distinctive inflammatory microenvironment of UC, including elevated reactive oxygen species, dysregulated pH, and enzyme overexpression. This microenvironment-responsive delivery system synergistically enhances therapeutic efficacy while minimizing off-target adverse effects. This review outlines the dynamic inflammatory microenvironment in UC and highlights its pivotal role in guiding the design of PIMRNs. It systematically summarizes recent advances in PIMRNs for UC treatment, articulates fundamental design principles along with optimization strategies to improve their performance, and discusses key challenges and future directions for their clinical translation. Through continued refinement, PIMRNs hold the potential to transform current UC treatment paradigms and enable precision therapy for a range of inflammatory disorders.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"380 ","pages":"Article 125069"},"PeriodicalIF":12.5,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146186777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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