Carbohydrate Polymers最新文献_第10页

Antibacterial functionalization of cellulose and cotton: A comprehensive review of cellulose-based strategies 纤维素和棉花的抗菌功能化：基于纤维素的策略的综合综述

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-01 Epub Date: 2025-12-21 DOI: 10.1016/j.carbpol.2025.124826

Marcin H. Kudzin , Jerzy J. Chruściel

{"title":"Antibacterial functionalization of cellulose and cotton: A comprehensive review of cellulose-based strategies","authors":"Marcin H. Kudzin , Jerzy J. Chruściel","doi":"10.1016/j.carbpol.2025.124826","DOIUrl":"10.1016/j.carbpol.2025.124826","url":null,"abstract":"<div><div>Cotton, composed primarily of cellulose, remains one of the most important natural fibers for medical and technical applications due to its biocompatibility, biodegradability, and mechanical stability. However, its hydrophilic nature promotes microbial colonization, creating a demand for efficient antibacterial functionalization. This review systematically summarizes and critically evaluates recent advances in chemical and physical modification strategies used to impart antimicrobial activity to cotton fabrics. Particular attention is given to cellulose-based surface engineering involving metal and metal oxide nanoparticles (Ag, Cu, ZnO, TiO₂); quaternary ammonium compounds; halamine derivatives, photoactive coatings; plant extracts; antibiotics; and organosilicon agents. The underlying mechanisms of antibacterial action-such as reactive oxygen species generation, membrane disruption, ion release, and photodynamic inactivation-are discussed in correlation with material structure and durability. Comparative analysis highlights the advantages and limitations of eco-friendly biogenic modifiers versus traditional metal-based systems. The review concludes by outlining emerging research trends in smart, multifunctional cotton textiles for biomedical and hygienic applications, emphasizing the importance of sustainable, regenerable, and non-toxic functionalization pathways.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 124826"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxypropyl methylcellulose–reinforced metal–ligand coordination–entanglement eutectogels for highly sensitive, flexible temperature sensors 高灵敏度、柔性温度传感器用羟丙基甲基纤维素增强金属配体配位缠结共凝胶

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-05-01 Epub Date: 2026-01-27 DOI: 10.1016/j.carbpol.2026.125025

Yapeng Zheng , Jing Wang , Tianyang Cui , Jingwen Wang , Yuquan Chen , Mingyu Ou , Yuan Hu , Zhou Gui

{"title":"Hydroxypropyl methylcellulose–reinforced metal–ligand coordination–entanglement eutectogels for highly sensitive, flexible temperature sensors","authors":"Yapeng Zheng , Jing Wang , Tianyang Cui , Jingwen Wang , Yuquan Chen , Mingyu Ou , Yuan Hu , Zhou Gui","doi":"10.1016/j.carbpol.2026.125025","DOIUrl":"10.1016/j.carbpol.2026.125025","url":null,"abstract":"<div><div>Accurate detection and efficient transduction of thermal stimuli across biological, environmental, and electronic settings are essential for flexible temperature sensors that underpin electronic skin, human–machine interfaces, and hazard monitoring. Yet, flexible sensors still face inherent trade-offs between sensitivity, operating range, and stability. Established strategies—hydrogels (dehydration/icing), ionogels (ion leakage/structural degradation), and conductive filler/elastomer composites (rigidity–flexibility compromise)—remain constrained. Here, a metal–ligand coordination–entanglement co-driven strategy is implemented within a tailored solvent framework comprising deep eutectic and polymerizable solvent systems to form P(AA-co-AAM)/LiTFSI/ZnCl<sub>2</sub>–EG/hydroxypropyl methylcellulose (HPMC) eutectogels. Physical entanglement of HPMC coupled with metal-ion coordination creates reconfigurable ion-transport pathways and programmable mechanical networks, enabling high-sensitivity and robust temperature sensing. The resulting eutectogel-based flexible temperature sensor demonstrates high sensitivity (temperature coefficient of resistance, TCR = −12.86% °C<sup>−1</sup>), a fine temperature resolution of 0.10 °C, excellent linearity (R<sup>2</sup> = 0.990), and stable operation across 6–90 °C. Relative to state-of-the-art flexible sensors—including hydrogels, ionogels, elastomers, and electronic conductors—the eutectogel sensor delivers a high B value (~4840 K), high TCR, fine resolution, strong linearity, and a broad operating window. Together, these findings identify metal coordination–entanglement co-driven eutectogels as ideal sensing platforms that couple exceptional sensitivity with broad operational adaptability.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"379 ","pages":"Article 125025"},"PeriodicalIF":12.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of grafted groups on adsorption conformation and adsorption behavior of guar gum: insights from molecular interactions 接枝基团对瓜尔胶吸附构象和吸附行为的影响：来自分子相互作用的见解

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-04-15 Epub Date: 2026-01-20 DOI: 10.1016/j.carbpol.2026.124974

Peng Shi , Shibin Wang , Fengjie Ma , Mian Zhang , Hongbo Zeng

{"title":"Effect of grafted groups on adsorption conformation and adsorption behavior of guar gum: insights from molecular interactions","authors":"Peng Shi , Shibin Wang , Fengjie Ma , Mian Zhang , Hongbo Zeng","doi":"10.1016/j.carbpol.2026.124974","DOIUrl":"10.1016/j.carbpol.2026.124974","url":null,"abstract":"<div><div>The adsorption conformation of guar gum molecules on silica surfaces determines the structural characteristics of the adsorption layer, potentially enabling diverse functionalities in engineering applications. However, the influence of grafted groups on the adsorption characteristics of guar gum remains unclear. The adsorption conformations and morphologies of unmodified ordinary guar gum (GG) and three modified guar gums — hydroxypropyl guar gum (HPG), carboxymethyl guar gum (CMG), and hydroxypropyl trimethylammonium chloride guar gum (HPTCG) — on silica surfaces were investigated via molecular dynamics simulations and AFM topography. The adsorption behavior of four guar gums was investigated by QCM-D experiment. The four guar gums exhibited distinct adsorption conformations: GG formed a mushroom-like structure, HPG adopted a “lying-flat” conformation with moderate folding, CMG presented an “L-shaped” orientation, and HPTCG displayed an upright conformation. AFM adhesion force measurements and chemical calculations indicated that the types and intensities of interactions between the four guar gums and silica surfaces varied. These differences result in different adsorption capacities, diffusion coefficients, adsorption layer stability, and layer structural characteristics of the four guar gums on silica surfaces. The results provide valuable insights for the molecular design of guar gum derivatives and their potential applications in interfacial fields.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124974"},"PeriodicalIF":12.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural properties of two glycans in the fruits of jujube and their regulation effect of M1-type and M2-type macrophage 枣果实中两种聚糖的结构特性及其对m1型和m2型巨噬细胞的调节作用

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-04-15 Epub Date: 2026-01-21 DOI: 10.1016/j.carbpol.2026.124981

Jingya Ruan , Ping Zhang , Jiaming Cheng , Lequan Yu , Yijin Wu , Yinuo Zheng , Yi Zhang , Tao Wang

{"title":"Structural properties of two glycans in the fruits of jujube and their regulation effect of M1-type and M2-type macrophage","authors":"Jingya Ruan , Ping Zhang , Jiaming Cheng , Lequan Yu , Yijin Wu , Yinuo Zheng , Yi Zhang , Tao Wang","doi":"10.1016/j.carbpol.2026.124981","DOIUrl":"10.1016/j.carbpol.2026.124981","url":null,"abstract":"<div><div>Two glycans, <strong>ZJPr2–2-1</strong> and <strong>ZJPr3–2-1</strong>, were isolated from jujube fruits. Structural analysis revealed <strong>ZJPr2–2-1</strong> (7.20 kDa) as a previously unreported pectin featuring main chain of →4)-<em>α</em>-D-Gal<em>p</em>A-(1→, →3,4)-<em>α</em>-D-Gal<em>p</em>A-(1→, and →3)-<em>α</em>-L-Rha<em>p</em>-(1→, with side chains containing →4)-<em>α</em>-L-Ara<em>p</em>-(1→, and t-4-deoxy-L-<em>threo</em>-hex-4-enopyranuronic acid (t-<em>α</em>-L-HexA), as well as two isolated fragments linked to →4)-<em>β</em>-D-Gal<em>p</em>A, →4)-<em>α</em>-D-Gal<em>p</em>A. Nevertheless, the absence of HMBC correlations precluded the structural elucidation of its connected side chain. Meanwhile, <strong>ZJPr3–2-1</strong> was identified as the first plant-derived cyclic <em>α</em>-1,6-glucan heptasaccharide. Both glycans were found to promote M1 macrophage polarization (increased CD86 and decreased CD206 expression), and enhance the production of pro-inflammatory mediators (NO, iNOS, and TNF-<em>α</em>) in RAW264.7 cells. The mechanism was supposed to associated with the direct (<strong>ZJPr3–2-1</strong>) and indirect (<strong>ZJPr2–2-1</strong>) activation of the Dectin-1/Syk signaling pathway.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124981"},"PeriodicalIF":12.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146024204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in ultrasound-assisted starch modification: Parameter optimization, structure–property relationships, and synergistic strategies 超声辅助淀粉改性的研究进展：参数优化、结构-性能关系和协同策略

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-04-15 Epub Date: 2026-01-07 DOI: 10.1016/j.carbpol.2026.124907

Xining He , Liang Lyu , Yawen Luo , Xiaoyuan Zheng , Fankui Zeng

{"title":"Advances in ultrasound-assisted starch modification: Parameter optimization, structure–property relationships, and synergistic strategies","authors":"Xining He , Liang Lyu , Yawen Luo , Xiaoyuan Zheng , Fankui Zeng","doi":"10.1016/j.carbpol.2026.124907","DOIUrl":"10.1016/j.carbpol.2026.124907","url":null,"abstract":"<div><div>Ultrasound-assisted starch modification has emerged as a promising green and efficient physical approach to improve the functionality of native starches. This review systematically summarizes recent progress in this field, emphasizing the optimization of ultrasonic parameters, structure–property correlations, and synergistic modification strategies. Ultrasonication induces cavitation and mechanical shear effects that disrupt starch crystalline regions, alter granule morphology, and increase specific surface area, resulting in enhanced solubility, hydrophilicity, and functional performance. The relationships between ultrasonic power, duration, temperature, and starch concentration and their effects on structural and physicochemical changes—such as crystallinity, thermal stability, rheology, and digestibility—are critically analyzed. Synergistic modification strategies combining ultrasound with enzymatic, chemical, or thermal treatments are also discussed, highlighting their potential to achieve controllable structural tailoring and improved efficiency. Finally, the review provides insights into current challenges and future prospects for industrial-scale applications of ultrasound-assisted starch modification, focusing on the development of intelligent, energy-efficient, and sustainable technologies for advanced starch-based materials.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124907"},"PeriodicalIF":12.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural elucidation and effects on gut microbiota of soluble galactans from edible Boletus 可食性牛乳菌可溶性半乳的结构分析及其对肠道菌群的影响

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-04-15 Epub Date: 2026-01-03 DOI: 10.1016/j.carbpol.2026.124886

Yunzhang Ding , Xuan Li , Yuxuan Hao , Peizhi Ding , Nanyu Chen , Lan luo , Chuanxing Wan , Mingyi Wu

{"title":"Structural elucidation and effects on gut microbiota of soluble galactans from edible Boletus","authors":"Yunzhang Ding , Xuan Li , Yuxuan Hao , Peizhi Ding , Nanyu Chen , Lan luo , Chuanxing Wan , Mingyi Wu","doi":"10.1016/j.carbpol.2026.124886","DOIUrl":"10.1016/j.carbpol.2026.124886","url":null,"abstract":"<div><div>Edible <em>Boletus</em> mushrooms hold considerable development potential due to their exceptional nutritional and biological profiles. This study characterized two novel galactans, NBP and BRP, extracted from <em>Neoboletus brunneissimus</em> and <em>Butyriboletus roseoflavus</em>, respectively. Structural analysis revealed that both NBP and BRP possess a backbone composed of α-1,6-linked galactopyranosyl residues substituted at <em>O</em>-2, with structural diversity arising from variations in the side-chain substituents. Although both polysaccharides exhibit low viscosities, BRP forms a shear-stable elastic gel network, contrasting with the predominantly linear structure of NBP. In vitro fermentation demonstrated that both galactans markedly promoted the proliferation of beneficial probiotics, optimized gut microbiota composition, and enriched butyrate-producing bacteria including <em>Faecalibacterium prausnitzii</em>. Furthermore, they stimulated the production of lactic acid and short-chain fatty acids (SCFAs), leading to a reduction in fermentation pH and thereby modulating microbial ecology and host energy metabolism. Metagenomic annotation revealed that galactan degradation was driven by glycoside hydrolases (GHs) from Bacteroidaceae, and molecular docking analyses indicated that these GHs exhibit distinct binding preferences for specific structural regions of the polysaccharides. These results explain the basis for the microbiota-dependent improvement of gut health by Boletus galactans, providing a theoretical foundation for their development as precision prebiotics.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124886"},"PeriodicalIF":12.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical and biological properties of carboxymethyl cellulose/locust bean gum composite films reinforced with nano- or microfibrillated cellulose loaded with essential oil 负载精油的纳米或微纤化纤维素增强羧甲基纤维素/刺槐豆胶复合膜的物理化学和生物学特性

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-04-15 Epub Date: 2026-01-22 DOI: 10.1016/j.carbpol.2026.125000

Kamila Ferreira Chaves , Walter Cesar Celeri Bigui , Jhennifer Capichoni Zampilli , Ana Flávia Batista Silva , Bianca de Oliveira Botelho Vital , Carlos Eduardo de Souza Duarte , Mariana Drummond Costa Ignacchiti , Juliana Alves Resende , Michel Picanço Oliveira , Adilson Vidal Costa , Lucas de Souza Soares , Vagner Tebaldi de Queiroz

{"title":"Physicochemical and biological properties of carboxymethyl cellulose/locust bean gum composite films reinforced with nano- or microfibrillated cellulose loaded with essential oil","authors":"Kamila Ferreira Chaves , Walter Cesar Celeri Bigui , Jhennifer Capichoni Zampilli , Ana Flávia Batista Silva , Bianca de Oliveira Botelho Vital , Carlos Eduardo de Souza Duarte , Mariana Drummond Costa Ignacchiti , Juliana Alves Resende , Michel Picanço Oliveira , Adilson Vidal Costa , Lucas de Souza Soares , Vagner Tebaldi de Queiroz","doi":"10.1016/j.carbpol.2026.125000","DOIUrl":"10.1016/j.carbpol.2026.125000","url":null,"abstract":"<div><div>Recent studies have proposed the incorporation of different reinforcing materials into biopolymer films to improve their properties. In this study, carboxymethyl cellulose/locust bean gum composite films reinforced with nanofibrillated (NFC) or microfibrillated (MFC) cellulose loaded with oregano essential oil (OEO) were analyzed in terms of physical properties, microstructure, and molecular interactions, using FTIR, RXD, TGA, and DSC. Reinforced composite films (RCF) presented a significant (<em>p</em> ≤ 0.05) increase in thickness compared to the control, while RCF loaded with OEO did not modify their WVP (ranging from 91.73 to 120.18 g/m<sup>2</sup>/day). FTIR spectra indicated intermolecular interactions between NFC or MFC and other film constituents, and a distinct pattern of interactions was observed in RCF loaded with OEO, evidenced by alterations in peaks at 1580 and 1420 cm<sup>−1</sup>. RCF with NFC or MFC presented similar OEO release behavior. RCF loaded with OEO completely inhibited fungal growth and spore germination of <em>F oxysporum</em> f. sp. <em>lycopersici</em> (Fol), and no phytotoxic effects were observed when used to coat tomato seeds. These findings highlight the potential of RCF as sustainable seed treatment alternatives due to their ability to stabilize OEO, ensure controlled release, inhibit fungal growth, and prevent phytotoxic effects.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 125000"},"PeriodicalIF":12.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose-based ultralight foam with dual-scale porosity from hybrid fibers for sustainable oil-water separation 基于纤维素的超轻泡沫，混合纤维具有双尺度孔隙度，可实现油水分离

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-04-15 Epub Date: 2026-01-10 DOI: 10.1016/j.carbpol.2026.124905

Weiqiang Li , Jingge Liu , Meiying Li , Haitao Lin , Jian Fang , Xiaoqiao Wang , Jianchu Xu , Yuling Li , Junze Zhang , Xinheng Li , Gang Li

{"title":"Cellulose-based ultralight foam with dual-scale porosity from hybrid fibers for sustainable oil-water separation","authors":"Weiqiang Li , Jingge Liu , Meiying Li , Haitao Lin , Jian Fang , Xiaoqiao Wang , Jianchu Xu , Yuling Li , Junze Zhang , Xinheng Li , Gang Li","doi":"10.1016/j.carbpol.2026.124905","DOIUrl":"10.1016/j.carbpol.2026.124905","url":null,"abstract":"<div><div>Industrial wastewater and oil spills are increasingly deteriorating the natural environment, driving demands for superhydrophobic oil-water separation materials. However, developing sustainable absorbents for oil spill remediation is challenging due to the typical trade-off between high absorption capacity and low mechanical robustness. Here, we present a biomass-derived ultralight foam using cellulose for environmental remediation, fabricated through integration of vinyltrimethoxysilane-modified <em>Calotropis gigantea</em> fiber (CGF) and microfibrillated cellulose (MFC). The hollow structure of CGF (pore size 8–15 μm) and the nanofibrous network of MFC synergistically combine to achieve ultralow density (6.12 ± 0.21 mg/cm<sup>3</sup>) and exceptional porosity (99.60 ± 0.14 %). The foam exhibits hydrophobicity (water contact angle of 141.2 ± 0.63°), adsorption capacity of 152.45 ± 5.65 g/g (for chloroform), oil uptake of 139.6 ± 3.17 g/g within 5 s (for dichloromethane), and separation flux of 29,257.9 ± 1491.3 L m<sup>−2</sup> h<sup>−1</sup> (for dichloromethane). Owing to the incorporation of CGF, it exhibits a 38.2 % higher oil absorption capacity than that of pure foam. The foam possesses temperature stability in a range of −10 °C to 60 °C, and maintains a repetitive separation efficiency of 99.06 ± 0.27 %. Demonstrated in a pump system for continuous oil-water separation, this foam offers a promising sustainable material for environmental remediation.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124905"},"PeriodicalIF":12.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol-liposomes loaded polyvinyl alcohol-chitosan fiber scaffolds mediate bone regeneration via autophagy: synergizing angiogenesis and immunomodulation 白藜芦醇脂质体负载聚乙烯醇壳聚糖纤维支架通过自噬介导骨再生：协同血管生成和免疫调节

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-04-15 Epub Date: 2026-01-16 DOI: 10.1016/j.carbpol.2026.124945

Tingting Ma , Yiran Li , Aolong Li , Siluo Dai , Zhengyang Qin , Yubao Li , Jidong Li

{"title":"Resveratrol-liposomes loaded polyvinyl alcohol-chitosan fiber scaffolds mediate bone regeneration via autophagy: synergizing angiogenesis and immunomodulation","authors":"Tingting Ma , Yiran Li , Aolong Li , Siluo Dai , Zhengyang Qin , Yubao Li , Jidong Li","doi":"10.1016/j.carbpol.2026.124945","DOIUrl":"10.1016/j.carbpol.2026.124945","url":null,"abstract":"<div><div>The core difficulty in bone defect repair lies in the simultaneous regulation of immunity, angiogenesis and osteogenesis. In this study, hydrophobic resveratrol (Res) was encapsulated in liposomes (LP), and then <em>co</em>-spun with polyvinyl alcohol-chitosan (PVA-CS) to construct a “drug-liposome-fiber” multi-level drug-controlled-release scaffold (RL/PVA-CS). Physicochemical characterization confirmed that this scaffold could sustain the release of Res, and CS incorporation significantly enhanced mechanical properties of the PVA-based fiber scaffold. In vitro studies confirmed that the RL/PVA-CS scaffold not only efficiently scavenged free radicals, regulated macrophage polarization to M2 type to improve the immune microenvironment, but also demonstrated a significant potential for promoting angiogenesis. Moreover, this scaffold could effectively recruit bone marrow mesenchymal stem cells (BMSCs) and drove their osteogenic differentiation and matrix mineralization by activating the autophagy pathway. In a rat cranial defect model, the implantation of the RL/PVA-CS scaffold demonstrated excellent angiogenic ability and osteogenic performance, significantly accelerating bone defect repair. The main innovation of this study is the development of a dual-release and multi-functional synergistic RL/PVA-CS fiber scaffold. This system effectively protects drug activity, overcomes single-function limits of traditional materials, coordinates immunity, angiogenesis and osteogenesis via autophagy, offering an integrated solution for complex bone defects.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124945"},"PeriodicalIF":12.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating heparan sulfate mimetics into LbL nanofilms as extracellular matrix-like architectures to promote bone tissue regeneration 将硫酸肝素模拟物整合到LbL纳米膜中作为细胞外基质样结构促进骨组织再生

IF 12.5 1区化学

Carbohydrate Polymers Pub Date : 2026-04-15 Epub Date: 2026-01-12 DOI: 10.1016/j.carbpol.2026.124922

E. Bullier-Marchandin , L. Rossignol , A. Echalard , S. Morin-Grognet , J. Maucotel , A. Arabo , D. Barritault , G. Ladam , B. Labat

{"title":"Integrating heparan sulfate mimetics into LbL nanofilms as extracellular matrix-like architectures to promote bone tissue regeneration","authors":"E. Bullier-Marchandin , L. Rossignol , A. Echalard , S. Morin-Grognet , J. Maucotel , A. Arabo , D. Barritault , G. Ladam , B. Labat","doi":"10.1016/j.carbpol.2026.124922","DOIUrl":"10.1016/j.carbpol.2026.124922","url":null,"abstract":"<div><div>Biomimetic surfaces are increasingly needed to enhance the effectiveness of biomaterials in bone tissue repair. The Layer-by-Layer (LbL) technique is a particularly attractive method due to its versatility and ability to incorporate a wide range of bioactive molecules under mild conditions. While numerous LbL systems have been developed, those integrating glycosaminoglycans (GAG) are often reported to rapidly degrade, which limits their potential in tissue integration. To address this limitation, we investigated the incorporation of ReGeneraTing Agents® (RGTA®) into LbLs. RGTA® are glycanase-resistant analogues of heparan sulfate, designed to protect and stabilize growth factors. To date, their use is restricted to soluble formulations or adsorptions onto biomaterial surfaces. Here, we propose a novel approach to immobilize two RGTA® (OTR4120 and OTR4131) within LbL architectures to produce bone extracellular matrix-like microenvironments. We revealed that OTR4120 potentiated much more <em>in vitro</em> bone formation over OTR4131, with the synthesis of a mature mineralized hydroxyapatite-rich matrix only atop OTR4120 films. Subsequent <em>in vivo</em> translation of OTR4120 LbL films validated the osteogenic potentializing effect. This new strategy aimed at combining the regenerative potential of OTR4120 with the structural and functional advantages of the LbL assemblies, offering a new avenue for the development of biomimetic osteogenic materials.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"378 ","pages":"Article 124922"},"PeriodicalIF":12.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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