Carbohydrate Polymers最新文献

筛选
英文 中文
Corrigendum to "Dissecting the Enterococcal Polysaccharide Antigen (EPA) structure to explore innate immune evasion and phage specificity" [Carbohydr. Polym. 347 (1 January 2025) 122686].
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2025-02-01 Epub Date: 2024-11-18 DOI: 10.1016/j.carbpol.2024.122983
Jessica L Davis, Joshua S Norwood, Robert E Smith, Finn O'Dea, Krishna Chellappa, Michelle L Rowe, Mike P Williamson, Graham P Stafford, Evguenii Vinogradov, Emmanuel Maes, Yann Guérardel, Stéphane Mesnage
{"title":"Corrigendum to \"Dissecting the Enterococcal Polysaccharide Antigen (EPA) structure to explore innate immune evasion and phage specificity\" [Carbohydr. Polym. 347 (1 January 2025) 122686].","authors":"Jessica L Davis, Joshua S Norwood, Robert E Smith, Finn O'Dea, Krishna Chellappa, Michelle L Rowe, Mike P Williamson, Graham P Stafford, Evguenii Vinogradov, Emmanuel Maes, Yann Guérardel, Stéphane Mesnage","doi":"10.1016/j.carbpol.2024.122983","DOIUrl":"https://doi.org/10.1016/j.carbpol.2024.122983","url":null,"abstract":"","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"349 Pt A","pages":"122983"},"PeriodicalIF":10.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In situ growth of defective ZIF-8 on TEMPO-oxidized cellulose nanofibrils for rapid response release of curcumin in food preservation
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2024-11-30 DOI: 10.1016/j.carbpol.2024.123091
Zhihang Xu , Jian Du , Xingming Jin , Yehan Tao , Jie Lu , Jinwen Hu , Yanna Lv , Xiaodong Xia , Haisong Wang
{"title":"In situ growth of defective ZIF-8 on TEMPO-oxidized cellulose nanofibrils for rapid response release of curcumin in food preservation","authors":"Zhihang Xu ,&nbsp;Jian Du ,&nbsp;Xingming Jin ,&nbsp;Yehan Tao ,&nbsp;Jie Lu ,&nbsp;Jinwen Hu ,&nbsp;Yanna Lv ,&nbsp;Xiaodong Xia ,&nbsp;Haisong Wang","doi":"10.1016/j.carbpol.2024.123091","DOIUrl":"10.1016/j.carbpol.2024.123091","url":null,"abstract":"<div><div>Uncontrolled release of active agents in active packaging reduces antimicrobial efficacy, hindering the effective protection of perishable products from microbial infection. Herein, a novel defective engineering was proposed to design defective and hollow ZIF-8 structures grown on TEMPO oxidized cellulose nanofibrils (TOCNFs) and use them as fast-reacting nanocarriers for loading and controlled release curcumin (Cur) in sodium alginate (SA) active packaging systems (CZT-Cur-SA). By employing stable chelation between tannic acid (TA) and ZIF-8 zinc ions, the connections between zinc ions and imidazole ligands were severed to form a loose and hollow structure, which facilitates the rapid reaction and release of active ingredients triggered by pH changes in the microenvironment. Kinetic tests showed CZT-Cur-SA films released 65.68 % of Cur at pH 6.0 within 24 h, compared to 28.26 % at pH 7.0. These films demonstrated exhibited excellent mechanical properties, antioxidation capacity (82.59 %), reinforced moisture (0.51 × 10<sup>−10</sup> g m<sup>−1</sup> s<sup>−1</sup> Pa<sup>−1</sup>) and satisfied antimicrobial effects on <em>E. coli</em> (1.69 %) and <em>S. aureus</em> (0.88 %). The optimized CZT-Cur-SA film extended strawberry shelf life to at least 7 days under ambient conditions. Our findings introduce a promising approach to designing responsive, biodegradable active packaging for enhanced food safety.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"351 ","pages":"Article 123091"},"PeriodicalIF":10.7,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polydopamine-integrated cellulose/graphene oxide monoliths: A versatile platform for efficient continuous-flow iodine capture and photothermal-enhanced reduction of Cr(VI)
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2024-11-30 DOI: 10.1016/j.carbpol.2024.123090
Astrini Pradyasti , Myeong Joo Lee , Haiji Huang , Won Mook Choi , Mun Ho Kim
{"title":"Polydopamine-integrated cellulose/graphene oxide monoliths: A versatile platform for efficient continuous-flow iodine capture and photothermal-enhanced reduction of Cr(VI)","authors":"Astrini Pradyasti ,&nbsp;Myeong Joo Lee ,&nbsp;Haiji Huang ,&nbsp;Won Mook Choi ,&nbsp;Mun Ho Kim","doi":"10.1016/j.carbpol.2024.123090","DOIUrl":"10.1016/j.carbpol.2024.123090","url":null,"abstract":"<div><div>The global challenge of wastewater contamination, especially from persistent pollutants like radioactive isotopes and heavy metals, demands innovative purification solutions. Radioactive iodine isotopes (<sup>131</sup>I and <sup>129</sup>I), stemming from nuclear activities, pose serious health risks due to their mobility, bioaccumulation, and ionizing radiation, particularly impacting thyroid health. Similarly, hexavalent chromium, Cr(VI), is highly toxic and persistent in water, linked to cancer and other severe health issues. Developing effective technologies for iodine capture and Cr(VI) reduction is therefore critical for public health and environmental protection. This study presents two distinct cellulose-based composite materials tailored for environmental remediation: cellulose/graphene oxide/polydopamine (cellulose/GO/PDA) monoliths for iodine capture and cellulose/graphene oxide/polydopamine/palladium nano-crystals (cellulose/GO/PDA/Pd) monoliths for the reduction of Cr(VI). PDA substantially enhances the adsorptive, catalytic and photothermal properties of monoliths. The monoliths demonstrated exceptional performance in both batch and continuous-flow reactor studies. Complete iodine removal was achieved within 15 s, while Cr(VI) was entirely reduced within 9 min under dark conditions and 5 min under photothermal conditions. Continuous-flow experiments showed sustained iodine adsorption of 92 % and Cr(VI) reduction of 81 % over 240 min. This research highlights the potential of PDA-enhanced cellulose-based composites as highly efficient and sustainable platforms for practical water remediation and environmental protection.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"351 ","pages":"Article 123090"},"PeriodicalIF":10.7,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accelerating repair of infected bone defects through post-reinforced injectable hydrogel mediated antibacterial/immunoregulatory microenvironment at bone-hydrogel interface
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2024-11-29 DOI: 10.1016/j.carbpol.2024.123082
Zheng Wang , Ying Chu , Jingyi Du , Yan Hu , Huimin Wang , Hanghang Liu , Changying Yang , Man Wang , Jiabing Ran , Aixi Yu
{"title":"Accelerating repair of infected bone defects through post-reinforced injectable hydrogel mediated antibacterial/immunoregulatory microenvironment at bone-hydrogel interface","authors":"Zheng Wang ,&nbsp;Ying Chu ,&nbsp;Jingyi Du ,&nbsp;Yan Hu ,&nbsp;Huimin Wang ,&nbsp;Hanghang Liu ,&nbsp;Changying Yang ,&nbsp;Man Wang ,&nbsp;Jiabing Ran ,&nbsp;Aixi Yu","doi":"10.1016/j.carbpol.2024.123082","DOIUrl":"10.1016/j.carbpol.2024.123082","url":null,"abstract":"<div><div>Functional injectable hydrogel (IH) is promising for infected bone defects (IBDs) repair, but how to endow it with desired antibacterial/immunoregulatory functions as well as avoid mechanical failures during its manipulation has posed as main challenges. Herein, rosmarinic acid (RosA), a natural product with antibacterial/immunoregulatory activities, was utilized to develop a FCR IH through forming phenylboronic acid ester bonds with 4-formylphenyl phenylboronic acid (4-FPBA) grafted chitosan (CS) (FC). After being applied to the IBD site, the FCR IH was then injected with tobramycin (Tob) solution, another alkaline antibacterial drug, to induce <em>in situ</em> crystallization of the FC, endowing the resultant FCRT hydrogel with adaptively enhanced mechanical strength and structural stability. Owing to the specific structural composition, the FCRT hydrogel could sustainedly release Tob and RosA molecules at the IBD interface, effectively eliminating <em>in situ</em> bacterial infection. In addition, the released RosA molecules also induced the M<sub>2</sub> polarization of <em>in situ</em> macrophages (M<sub>φ</sub>), which was identified to be related to the NF-κB and PI3K-AKT pathways, therefore promoting the osteogenic differentiation of <em>in situ</em> bone marrow stromal cells (BMSCs). Due to the simultaneous antibacterial/osteo-immunoregulatory microenvironment at the IBD interface, the repair of IBDs was proved to be greatly accelerated by the FCRT hydrogel.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"351 ","pages":"Article 123082"},"PeriodicalIF":10.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation, characterization and antibacterial investigation of water-soluble curcumin-chitooligosaccharide complexes
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2024-11-29 DOI: 10.1016/j.carbpol.2024.123083
Xingchen Zhai , Yu Guo , Man Shang , Ziyan Guo , Difeng Ren , A.M. Abd El-Aty
{"title":"Preparation, characterization and antibacterial investigation of water-soluble curcumin-chitooligosaccharide complexes","authors":"Xingchen Zhai ,&nbsp;Yu Guo ,&nbsp;Man Shang ,&nbsp;Ziyan Guo ,&nbsp;Difeng Ren ,&nbsp;A.M. Abd El-Aty","doi":"10.1016/j.carbpol.2024.123083","DOIUrl":"10.1016/j.carbpol.2024.123083","url":null,"abstract":"<div><div>Curcumin has a wide range of application prospects, with various bioactivities in the food industry and in the biomedical field. However, curcumin has poor water solubility and is sensitive to pH, light and temperature. In this study, curcumin-chitooligosaccharide (CUR-COS) complexes were prepared via mechanochemical methods, and the CUR-COS complex was more soluble after freeze-drying (up to 862-fold greater than that of curcumin). The complex was characterized by SEM, XRD, FT-IR and thermal analysis, and its stability against pH, light and thermal treatment was evaluated. COSs could serve as carriers for curcumin delivery. Additionally, the antibacterial activity of the formed complex was determined. As a result, CUR-COS exhibited significantly better water solubility, enhanced stability, and stronger antibacterial properties than did pure CUR, offering a promising pathway for the extensive application of lipophilic natural products in foods, especially water-based products.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"351 ","pages":"Article 123083"},"PeriodicalIF":10.7,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Butyrylated modification of corn starch alleviates autism-like behaviors by modulating 5-hydroxytryptamine metabolism and gut-brain neural activity
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2024-11-28 DOI: 10.1016/j.carbpol.2024.123073
Wentian Li , Qingmin Kong , Min Guo , Linlin Wang , Peijun Tian , Jingyu Lu , Jianxin Zhao , Wei Chen , Gang Wang
{"title":"Butyrylated modification of corn starch alleviates autism-like behaviors by modulating 5-hydroxytryptamine metabolism and gut-brain neural activity","authors":"Wentian Li ,&nbsp;Qingmin Kong ,&nbsp;Min Guo ,&nbsp;Linlin Wang ,&nbsp;Peijun Tian ,&nbsp;Jingyu Lu ,&nbsp;Jianxin Zhao ,&nbsp;Wei Chen ,&nbsp;Gang Wang","doi":"10.1016/j.carbpol.2024.123073","DOIUrl":"10.1016/j.carbpol.2024.123073","url":null,"abstract":"<div><div>This study was conducted to elucidate the effects of different degrees of substitution (DS) on the properties of propionylated and butyrylated starches and to investigate their efficacy and mechanisms in ameliorating autism-like phenotypes. Fourier transform infrared spectra of propionylated and butyrylated starches revealed the presence of the C<img>O absorption peak at 1730 cm<sup>−1</sup>. Additionally, as the DS increased, the surface of the starch granules became rougher, and the crystallinity decreased. Moreover, in vitro digestion tests demonstrated that propionylated and butyrylated starches with a DS of approximately 0.25 exhibited enhanced resistance to digestion. Animal experiments indicated that butyrylated starch significantly improved abnormal behaviors in autism-like rats and increased butyrate accumulation in the colon. Furthermore, butyrylated starch normalized aberrant expression of G protein-coupled receptor 41 and tryptophan hydroxylase 1 in the colon, promoting 5-hydroxytryptamine metabolism and suppressing the expression of ionized calcium binding adaptor molecule 1 and glial fibrillary acidic protein in the gut and brain. These findings demonstrate that butyrylated starch effectively alleviates autism-like phenotypes in rats, supporting strategies to mitigate autism and develop new applications for natural corn starch.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"351 ","pages":"Article 123073"},"PeriodicalIF":10.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fe, N-CQDs triggered the fabrication of alginate encapsulated g-C3N4 hydrogel for efficient photocatalytic activation of PMS and antibiotic degradation
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2024-11-28 DOI: 10.1016/j.carbpol.2024.123072
Haiyan Yang , Xiao Cao , Yiyang He, Xinchao Zhang, Pingping Zhang, Xin Wang, Yuehong Liu, Suyun Xu, Yuyin Fang, Lin Gu
{"title":"Fe, N-CQDs triggered the fabrication of alginate encapsulated g-C3N4 hydrogel for efficient photocatalytic activation of PMS and antibiotic degradation","authors":"Haiyan Yang ,&nbsp;Xiao Cao ,&nbsp;Yiyang He,&nbsp;Xinchao Zhang,&nbsp;Pingping Zhang,&nbsp;Xin Wang,&nbsp;Yuehong Liu,&nbsp;Suyun Xu,&nbsp;Yuyin Fang,&nbsp;Lin Gu","doi":"10.1016/j.carbpol.2024.123072","DOIUrl":"10.1016/j.carbpol.2024.123072","url":null,"abstract":"<div><div>Carbon dots (CDs) mediated g-C<sub>3</sub>N<sub>4</sub> (CN) is a promising visible-light-driven semiconductor in catalyzing peroxymonosulfate (PMS) for aqueous contaminants remediation. However, the poor dispersibility of powered catalyst and its challenging recyclability impede their broader application. Herein, we embedded Fe<img>N bridge within the g-C<sub>3</sub>N<sub>4</sub> framework and immobilized g-C<sub>3</sub>N<sub>4</sub> gel beads (CA/FNCCN) through a 3D cross-linking process with sodium alginate. Alginate can serve as a stabilizing carrier, preserving the crystalline structure of FNCCN through the formation of H bonds between alginate and FNCCN. The resulting beads displayed significantly improved photo-electrochemical performance, along with greatly enhanced adsorption capacity and catalytic activity toward Sulfamethoxazole (SMX). The catalytic efficiency of CA/FNCCN was markedly increased as compared to non-immobilized FNCCN due to reduced photo-carrier recombination and accelerated electron transport. CA/FNCCN-1 can degrade 99.18 % of SMX within 40 mins, with noteworthy reduced Fe leaching. The primary active species in the system were <sup>1</sup>O<sub>2</sub> and h<sup>+</sup>, and the direct electron transfer between PMS and SMX mediated by alginate also contributed to the removal of SMX. Additionally, the degradation pathway of SMX was elucidated through LC-MS and DFT calculations. Simultaneously, FNCCN integrated alginate hydrogel can remain active without decay after 10 cycles.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"351 ","pages":"Article 123072"},"PeriodicalIF":10.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biocompatible dually reinforced gellan gum hydrogels with selective antibacterial activity
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2024-11-28 DOI: 10.1016/j.carbpol.2024.123071
Xixi Jin , Cuicui Wang , Zhaolong Sun , Yudong Lian , Quan Ji , Jinglong Tang , Xiaomei Ma
{"title":"Biocompatible dually reinforced gellan gum hydrogels with selective antibacterial activity","authors":"Xixi Jin ,&nbsp;Cuicui Wang ,&nbsp;Zhaolong Sun ,&nbsp;Yudong Lian ,&nbsp;Quan Ji ,&nbsp;Jinglong Tang ,&nbsp;Xiaomei Ma","doi":"10.1016/j.carbpol.2024.123071","DOIUrl":"10.1016/j.carbpol.2024.123071","url":null,"abstract":"<div><div>The poor mechanics and functionality of natural-polymer hydrogels from gellan gum (GG) prohibit their practical application, despite the intrinsic thermo-reversible gelation nature, structural and quality consistency, biocompatibility, biodegradability and sustainability of microbial fermentation-produced GG. Herein, a dual-reinforcing strategy, i.e., ionic-crosslinking along with rigid nano-particulate reinforcing, was realized to modify pristine GG hydrogels for the first time during the in-situ formation of zeolitic imidazolate framework-8 (ZIF-8). Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, rheology and X-ray diffraction confirm the synchronous formation of ZIF-8 and ionic bonds between Zn<sup>2+</sup> and –COO<sup>−</sup> of GG molecules. The mechanics of the final hydrogels are far superior to GG hydrogel, with the maximum compressive and tensile strength attaining 1.17 MPa and 592.2 kPa, ~4 times and ~ 66 times respectively of the corresponding GG hydrogel. Especially, the obtained hydrogels display selective antibacterial activity against <em>Staphylococcus aureus</em> as a modeling Gram positive strain. Whereas, the hydrogels retain good biocompatibility despite the introduction of ZIF-8 and Zn<sup>2+</sup> crosslinks, with the cell viability (NIH3T3 cells as the model) &gt;79 % after 48 h' cultivation in either the hydrogels or gel extracts. The excellent properties suggest them tremendous application prospects as biomedical materials, instrumental in averting drug-resistant problems.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"351 ","pages":"Article 123071"},"PeriodicalIF":10.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An injectable in situ-forming hydrogel with self-activating genipin-chitosan (GpCS) cross-linking and an O2/Ca2+ self-supplying capability for wound healing and rapid hemostasis
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2024-11-28 DOI: 10.1016/j.carbpol.2024.123051
Chi Lin , Tzu-Wei Lu , Fang-Yu Hsu , Tzu-Wen Huang , Ming-Hua Ho , Hsien-Tsung Lu , Fwu-Long Mi
{"title":"An injectable in situ-forming hydrogel with self-activating genipin-chitosan (GpCS) cross-linking and an O2/Ca2+ self-supplying capability for wound healing and rapid hemostasis","authors":"Chi Lin ,&nbsp;Tzu-Wei Lu ,&nbsp;Fang-Yu Hsu ,&nbsp;Tzu-Wen Huang ,&nbsp;Ming-Hua Ho ,&nbsp;Hsien-Tsung Lu ,&nbsp;Fwu-Long Mi","doi":"10.1016/j.carbpol.2024.123051","DOIUrl":"10.1016/j.carbpol.2024.123051","url":null,"abstract":"<div><div>Severe traumatic bleeding and chronic diabetic wounds require rapid hemostasis and multifunctional dressings, which remain particularly challenging, especially for non-compressible trauma and irregular wounds with dysregulated microenvironments. Chitosan (CS) can be easily cross-linked with genipin to form GpCS hydrogels. However, developing injectable GpCS hydrogels for biomedical applications faces challenges, particularly in enhancing rapid gel formation and optimizing physical properties. In this study, we present an innovative approach to improve these aspects by designing a novel injectable GpCS hydrogel, strategically enhanced through a calcium peroxide (CaO<sub>2</sub>)-activated cross-linking reaction. CaO<sub>2</sub> played a pivotal role in promoting in situ cross-linking of the GpCS hydrogel, leading to significant improvements in its injectable in situ gel-forming ability, mechanical strength, and self-healing and bioadhesive properties. CaO<sub>2</sub> incorporated in the hydrogels rapidly converted to oxygen when combined with catalase (CAT), thereby establishing a self-sustaining oxygen/calcium release system. This system not only promoted hyperoxia and activated the coagulation cascade, facilitating rapid blood clotting, but also significantly accelerated wound healing through enhanced angiogenesis, collagen deposition, and M2 macrophage polarization. These attributes significantly enhanced the capacity of the hydrogel to facilitate wound closure and hemostasis, highlighting its therapeutic value in accelerating recovery and improving healing outcomes in clinical wound care.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"351 ","pages":"Article 123051"},"PeriodicalIF":10.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual functionalization of carboxymethyl cellulose and alginate via Passerini three-component reaction to graft two hydrophobic moieties: Toward modular thin films
IF 10.7 1区 化学
Carbohydrate Polymers Pub Date : 2024-11-27 DOI: 10.1016/j.carbpol.2024.123066
C. Vuillet , C. Le Mouël , D. Albertini , P. Alcouffe , E. Fleury , A. Charlot
{"title":"Dual functionalization of carboxymethyl cellulose and alginate via Passerini three-component reaction to graft two hydrophobic moieties: Toward modular thin films","authors":"C. Vuillet ,&nbsp;C. Le Mouël ,&nbsp;D. Albertini ,&nbsp;P. Alcouffe ,&nbsp;E. Fleury ,&nbsp;A. Charlot","doi":"10.1016/j.carbpol.2024.123066","DOIUrl":"10.1016/j.carbpol.2024.123066","url":null,"abstract":"<div><div>Passerini reaction was advantageously exploited to hydrophobize carboxymethyl cellulose (CMC) and alginates (ALG) by employing various hydrophobic aldehydes and isocyanides. The Passerini reaction, carried out in ecofriendly conditions, allowed to design never described twofold hydrophobized polysaccharide derivatives <em>via</em> the covalent grafting of two hydrophobic moieties. The modified CMC and ALG products were in-depth characterized to guaranty the success of the modification and to calculate the degrees of substitution (DS). The impact of experimental parameters and especially the structure of the aliphatic reactants were thoroughly discussed. It appears that high conversions in carboxylic acid up to 70 % can be reached. Finally, the Passerini CMC and ALG products were processed as thin films exhibiting modular wettability properties varying from a moderate to a significant hydrophobicity adjustable by the structure of the grafts and the DS values. The film formation of selected CMC and ALG samples was examined by QCM-D experiments completed by AFM analysis under humid environment. It appears that the functionalization i) increases the adsorbed mass by inducing a more packed deposition and ii) closely governs the energy dissipation of the films. This overall approach paves the way toward new bio-based multifunctional films with potential utilizations in coating fields.</div></div>","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"351 ","pages":"Article 123066"},"PeriodicalIF":10.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信